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<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAS9</accession>
    <name>A0A386PAS9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_00545</name>
        <name evidence="5" type="ORF">EI377_11035</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00638"/>
    <dbReference type="EnsemblBacteria" id="AYE33043">
        <property type="protein sequence ID" value="AYE33043"/>
        <property type="gene ID" value="CP523_00545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61212">
        <property type="protein sequence ID" value="QAS61212"/>
        <property type="gene ID" value="EI377_11035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362688" description="Germane domain-containing protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="3">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="217" mass="24467" checksum="CF7305CD4447EB5F" modified="2018-12-05" version="1">MEVIFMKKKLSSFFLCLCIPFLLISCKDASDNNDSTKKQPNTTIESNTDIKKPSTEENVTNKKEDKTSSNIPTSEIKERNVRLYYYDSNQDKIIYLDSVVEVKDKAVATAIVNALKKPINENIPPTIAKNINIKSASVNLEKDLITIDFTDNFVKEQNLGSGSESMTLKAIANTFGYNFNVNHVKITLAGKPYSSGHISYNKDEFITVSYDNCFEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBL0</accession>
    <name>A0A386PBL0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="11">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pflA</name>
        <name evidence="13" type="ORF">CP523_02025</name>
        <name evidence="14" type="ORF">EI377_12545</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678883.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00127"/>
    <dbReference type="EnsemblBacteria" id="AYE33323">
        <property type="protein sequence ID" value="AYE33323"/>
        <property type="gene ID" value="CP523_02025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61493">
        <property type="protein sequence ID" value="QAS61493"/>
        <property type="gene ID" value="EI377_12545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="15"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="26695" checksum="03260600199A1CD8" modified="2018-12-05" version="1">MLKGRIHSIESMGLVDGPGIRVVVFMQGCALRCLYCHNPDTWKEEGGEEYTPQELVNKIERFKNYFKSSGGGVTFSGGDPLRQPEFLLEALKLCKETGIHTCLDTSGVGYGNYDEILKYTDLVLYDVKHLTEEGYKDMTGINMAETKKFLDACQRLGTKIWIRQVVVPGKTDSLEYMLKLKDFVNTLRNVEKVELLPYHLLGVNKYENLGLKYRLEGVPAMDKDKCKEFKELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBY5</accession>
    <name>A0A386PBY5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliM</name>
        <name evidence="11" type="ORF">CP523_02725</name>
        <name evidence="12" type="ORF">EI377_13250</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676958.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00951"/>
    <dbReference type="EnsemblBacteria" id="AYE33453">
        <property type="protein sequence ID" value="AYE33453"/>
        <property type="gene ID" value="CP523_02725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61624">
        <property type="protein sequence ID" value="QAS61624"/>
        <property type="gene ID" value="EI377_13250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00955">
        <property type="entry name" value="FLGMOTORFLIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01397">
        <property type="entry name" value="fliM_switch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="10">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="331" mass="37403" checksum="33A54C20125104B4" modified="2018-12-05" version="1">MAEVLSQNEIDALLSALSKGDVAPEELVEKDDKQKVKKYDFRSPQKFSKDHIRTLEMVHDSFARLVGNYLSGQLRKNVKVEIQSVEQITYQEFIHSIPNPTMITVFRMPPLQGNILLEMNPQFSFQILDILLGGTGDRKKYSKEFSEIDKNIISQITSDMISNLVLAWDGVLDVKPEFEGLETNPSANQTLGPNEPVALLSFSVELGRNTTYMNLCIPYLSVEKILDKLIVQYWFQTDEAALIEESRERLKEGLNPVEVSMHAEIGSTQVTVDDFLNLVIGDVLVLNTKSDNPIKVYVEDQECFIAKPGIVGKNMGIELLDILDKDVNEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC27</accession>
    <name>A0A386PC27_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="4">dUTPase</shortName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dut</name>
        <name evidence="6" type="ORF">CP523_02950</name>
        <name evidence="7" type="ORF">EI377_13465</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679179.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00022"/>
    <dbReference type="EnsemblBacteria" id="AYE33495">
        <property type="protein sequence ID" value="AYE33495"/>
        <property type="gene ID" value="CP523_02950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61664">
        <property type="protein sequence ID" value="QAS61664"/>
        <property type="gene ID" value="EI377_13465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02950"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="146" mass="16148" checksum="7CC81E69C268C997" modified="2018-12-05" version="1">MNEFNLRVQKIHKDAILPKYAHEGDAGLDLYSVEEVIIERNESALIKTGIKIELPKQTEAQVRPRSGLALKHGITVLNTPGTIDEGYRGEIGIILINHGKEKFVVEKGMKVAQMVVKPVWKVEVTEVNELSDTERSVGGFGSSGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC47</accession>
    <name>A0A386PC47_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose-1-phosphate uridylyltransferase</fullName>
            <shortName evidence="10">Gal-1-P uridylyltransferase</shortName>
            <ecNumber evidence="10">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">galT</name>
        <name evidence="13" type="ORF">CP523_02115</name>
        <name evidence="14" type="ORF">EI377_12635</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674076.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00543"/>
    <dbReference type="EnsemblBacteria" id="AYE33340">
        <property type="protein sequence ID" value="AYE33340"/>
        <property type="gene ID" value="CP523_02115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61510">
        <property type="protein sequence ID" value="QAS61510"/>
        <property type="gene ID" value="EI377_12635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02115"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00571">
        <property type="entry name" value="GalP_UDP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000766">
        <property type="entry name" value="GalP_uridyl_Trfase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023425">
        <property type="entry name" value="GalP_uridyl_Trfase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39191">
        <property type="entry name" value="PTHR39191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006005">
        <property type="entry name" value="GalT_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01239">
        <property type="entry name" value="galT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01163">
        <property type="entry name" value="GAL_P_UDP_TRANSF_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="11">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="12">
        <location>
            <begin position="250"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="504" mass="58758" checksum="AC55AB13E5D71BA4" modified="2018-12-05" version="1">MNINISYEIERLLVYGIKKGLIEVEDKVYVRNRIMQILNLNDIEEVEEINENLETPTSCLENILDYAFNERLLESNSVESRDLLDTKIMGCLVKMPSIIIKEFNKLYNESEKKATEYYYNLSRATNYIRVDRVKKDMKWKTATEYGDLDITINLSKPEKDPRDIAAKKNTVSTNYPKCLLCVENEGHEGRIGYPARENHRIIPLDLNNERWFLQYSPYVYYNEHCIVLKGSHDPMKITKDTFKRLLGFIEQFPHYFVGTNADLPIVGGSILAHDHFQGGNYEFSMAKAEVEKEFKIANLNKVKIGKVKWPMSVIRIEGKDKEEVLNAVIYIYEKWKNYSDESVDILAFTVDIPHNTVTPIARKKGGNYQFDLVLRNNRTTEEFPYGIFHPHEELHHIKKENIGLIEAMGLAILPSRLKKELKEIQDFLLNKNKIEELNGKEELLKHKDWILTIIKKYKDINSENVEDILQEEVGLKFLAVLKDAGVYKRDEKGQQAFDKFIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCV4</accession>
    <name>A0A386PCV4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8 and S53 subtilisin kexin sedolisin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03625</name>
        <name evidence="7" type="ORF">EI377_14155</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677724.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02220"/>
    <dbReference type="EnsemblBacteria" id="AYE33620">
        <property type="protein sequence ID" value="AYE33620"/>
        <property type="gene ID" value="CP523_03625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61784">
        <property type="protein sequence ID" value="QAS61784"/>
        <property type="gene ID" value="EI377_14155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="100"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="440"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="603" mass="66867" checksum="22D2C22D2BE85BCD" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCW8</accession>
    <name>A0A386PCW8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04715</name>
        <name evidence="2" type="ORF">EI377_15225</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675811.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33823">
        <property type="protein sequence ID" value="AYE33823"/>
        <property type="gene ID" value="CP523_04715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61969">
        <property type="protein sequence ID" value="QAS61969"/>
        <property type="gene ID" value="EI377_15225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="429" mass="49231" checksum="01C3B3C1C21E4194" modified="2018-12-05" version="1">MDLDKKNIITIINDKIDYSFLSMCNDAKLIYVNGSGKLKTSTSIVEDSYYGMRYLKQITLNDIPLVKINSPSCPTCKCILSLGLGINKVNSHELMEISNKINSNFISLETSINDLESLLSLLESGLYVIADILCYPTDGDGNFFWNIPNRPTEYSGTVGVLLPEDDYNYVDGEPVFLYPTEDTSCFNEERVEYYLNTINNSESPPRAIVYNFKEFMSFIIDGHHKTCAASILRRPVNCIAIIPVSAYEYRKNGDEMLIDSLCFSNIRINSNDIPVQYLTQKSKKEFLVDKNKVELSEGRFKNTSWAQKYLDSSKYYPTVEEYAEMISSEVYNISDELIEECLENLNNENQKRMKKILFYLSNREDIRLKKIAIICAKKLGDCKLKVQAFKILSNIKDDTEIEELFIDYLIENEDKHSILREIANIGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCY3</accession>
    <name>A0A386PCY3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04820</name>
        <name evidence="3" type="ORF">EI377_15330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01710"/>
    <dbReference type="EnsemblBacteria" id="AYE33843">
        <property type="protein sequence ID" value="AYE33843"/>
        <property type="gene ID" value="CP523_04820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61989">
        <property type="protein sequence ID" value="QAS61989"/>
        <property type="gene ID" value="EI377_15330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="121"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="731" mass="84324" checksum="D4394156F039A93E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCZ9</accession>
    <name>A0A386PCZ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675508.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01548"/>
    <dbReference type="EnsemblBacteria" id="AYE33670">
        <property type="protein sequence ID" value="AYE33670"/>
        <property type="gene ID" value="CP523_03890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="196" mass="23331" checksum="494EC09DA7EF797D" modified="2018-12-05" version="1">MVRTYAYSANLDKETEKLFRSAEFLGEGHNGIVYELPGNRAIKIFQQSKCCMDEGRVLKRVSKSKFFPNVYSVGNHYIVREKIGGERLDHYIKKNGLSYKLCKNLFDLIKEFKHLRFTKLDARCRDIYVLDDETVRVIDPKQCYTKKVTYPRHLMKGFKKIDCLDEFLENIKAIDKKIGQEWETRINKYFYDNERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD42</accession>
    <name>A0A386PD42_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2207 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01585</name>
        <name evidence="4" type="ORF">EI377_12105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00870"/>
    <dbReference type="EnsemblBacteria" id="AYE33244">
        <property type="protein sequence ID" value="AYE33244"/>
        <property type="gene ID" value="CP523_01585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61416">
        <property type="protein sequence ID" value="QAS61416"/>
        <property type="gene ID" value="EI377_12105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788372" evidence="2">
        <location>
            <begin position="23"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="558" mass="63530" checksum="984C9FB6D2920A21" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD73</accession>
    <name>A0A386PD73_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PELOTA_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05360</name>
        <name evidence="3" type="ORF">EI377_15925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677988.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02596"/>
    <dbReference type="EnsemblBacteria" id="AYE33943">
        <property type="protein sequence ID" value="AYE33943"/>
        <property type="gene ID" value="CP523_05360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62095">
        <property type="protein sequence ID" value="QAS62095"/>
        <property type="gene ID" value="EI377_15925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028157">
        <property type="entry name" value="PELOTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011215">
        <property type="entry name" value="PRTase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15608">
        <property type="entry name" value="PELOTA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11202">
        <property type="entry name" value="PRTase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020979">
        <property type="entry name" value="UCP020979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PELOTA_1" evidence="1">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="357" mass="40816" checksum="0B025F239BAF51EC" modified="2018-12-05" version="1">MDKLVKHSYKDDCIFLLKDLSSDIKEITIEEKESLIRAGVNYSEMISKESVPSEEIKNIFLNILDRDKEKIAYYVAKLSELIYEEKGDNLVIVSLARAGTPYGVLIKKYLKYKYKVDIPHYSISIIRGKGIDANALKFILKEHPQGKIQFVDGWTGKGSITKELNKSVGIFNKKNNFNVDDSLAVISDPAKLCKVCGTREDFGIATCCLNSTVSGLISRTIHNANYIGKDDFHGAKYLEYLKIEDYSQKFIDIIKNEFEKISIDKKDLIREEVDTSYSVRITKDIQDMFKINNVNNIKLSVGESARVLLRRDPQVVLVRDINNKNIEHIVQLAKEKNVKIIEYSKSHYNCIAIIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD90</accession>
    <name>A0A386PD90_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">csrA</name>
        <name evidence="5" type="ORF">CP523_02690</name>
        <name evidence="6" type="ORF">EI377_13215</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676946.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00944"/>
    <dbReference type="EnsemblBacteria" id="AYE33447">
        <property type="protein sequence ID" value="AYE33447"/>
        <property type="gene ID" value="CP523_02690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61618">
        <property type="protein sequence ID" value="QAS61618"/>
        <property type="gene ID" value="EI377_13215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="71" mass="8052" checksum="8040D17088EFF72A" modified="2018-12-05" version="1">MLVITRKKGESILIGDDIEISISKIEDGSVKLAVKAPKEVTILRKELYKEVKEENIQATKIDINMLKNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDD7</accession>
    <name>A0A386PDD7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EAL domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">GGDEF-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02960</name>
        <name evidence="6" type="ORF">EI377_13475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679181.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00024"/>
    <dbReference type="EnsemblBacteria" id="AYE33497">
        <property type="protein sequence ID" value="AYE33497"/>
        <property type="gene ID" value="CP523_02960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61666">
        <property type="protein sequence ID" value="QAS61666"/>
        <property type="gene ID" value="EI377_13475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="90"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="3">
        <location>
            <begin position="232"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="491" mass="56991" checksum="A1EC9B5CA1777B31" modified="2018-12-05" version="1">MGMRQRVLIMFITVILFIESVIILRKDVNIIWLIIIILGYFLMIKEIYLENSYEKLYMMSEYDVVTGVPNRRYFINEMDKIIKKSQKNKDKIAVVFIDLDNFKCINDTYGHYLGDKVLVGFCNVLSEFFYDKSLISRFGGDEFVVAKYGIKDLKEIKDILDRLYKTLYNPIIIEDREIYCAMSIGVSIYPTDGEDTETLLTKADMTMYKAKSDGKNKYKIYDRSVLDSLNKDNKLEMALKSAINNNEIYLVYQSKVNSITEELEGYECLVRWNSKELGNVSSTKFIPIAESTGLILILGKYIIDCAFQNCKELILKTNKNFKISINLSYIQIRDEKLVDYIKSKLKEYNLDSHYIEFEIAESAIMKSFSKNIKVLNELKALGVSIALDDFGSGYSSLEYLRLLPIDVLKIDNRIIKQINKDENINNMIESIVELSNTLNLRVVAEGVETRIQQEYLRNIGCDIIQDSYYNTPNRLDMVSQMIIIKQEKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDK0</accession>
    <name>A0A386PDK0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetobutylicum phosphotransbutyrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04960</name>
        <name evidence="5" type="ORF">EI377_15460</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675723.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01685"/>
    <dbReference type="EnsemblBacteria" id="AYE33870">
        <property type="protein sequence ID" value="AYE33870"/>
        <property type="gene ID" value="CP523_04960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62012">
        <property type="protein sequence ID" value="QAS62012"/>
        <property type="gene ID" value="EI377_15460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788345" evidence="2">
        <location>
            <begin position="28"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="3">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="21462" checksum="9CE6460966ED6E64" modified="2018-12-05" version="1">MKKIVMGILVIASIGFIFLNSSQNGQKSNSRSKSIVYTIIEKFSNNSEDAFSSNGDCKYKASKLNFIIRKIAHGLEFLLLATVVSVFLSTLGLKLREIITYSLFTVLFLAVMDEFYQLYIPSRYSSVKDVLIDFTGGFVGTILTCICINIFKEIRRKKERQRMRIRRERRMRRSLKEEKYKPEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDK7</accession>
    <name>A0A386PDK7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MinD/ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_02520</name>
        <name evidence="5" type="ORF">EI377_13055</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673941.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00463"/>
    <dbReference type="EnsemblBacteria" id="AYE33414">
        <property type="protein sequence ID" value="AYE33414"/>
        <property type="gene ID" value="CP523_02520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61588">
        <property type="protein sequence ID" value="QAS61588"/>
        <property type="gene ID" value="EI377_13055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02038">
        <property type="entry name" value="FlhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033875">
        <property type="entry name" value="FlhG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="3">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="31742" checksum="6A6382E78B2EEEA0" modified="2018-12-05" version="1">MLDQAESLRKLVNGEKSSVDKKARIITITSGKGGVGKSNFVVNLAITLQKQGKRVLIFDADIGMGNDDVLMGLFPKYNVLDLINGEKSIEEVIVDGPAGVKLLPGGSGLNNIEDLQEHEREIFLKKIEMLEGFDFIFIDTGAGISRSVLAFIACAEEFILVTTPEPTSLTDGYSLVKSVDRFKIKTKANIVVNKVFDLKEGEKTFYKFKLAVERFLNMKVNYLGCVYEDRNLLMAVREQVPFVVSYPNCDAARCIRKISNLITHTNSKVNGIGAKGLFKRLFDIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDP8</accession>
    <name>A0A386PDP8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_01000</name>
        <name evidence="10" type="ORF">EI377_11495</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674510.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PDP8"/>
    <dbReference type="STRING" id="1504.GCA_900092375_02319"/>
    <dbReference type="EnsemblBacteria" id="AYE33131">
        <property type="protein sequence ID" value="AYE33131"/>
        <property type="gene ID" value="CP523_01000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61301">
        <property type="protein sequence ID" value="QAS61301"/>
        <property type="gene ID" value="EI377_11495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="8">
        <location>
            <begin position="208"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="3">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604550-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="323" mass="34666" checksum="06E0D25A9B7AA1AB" modified="2018-12-05" version="1">MKKIAVVFNGGTISMKVDERIKAAVPSLTGEEIMSMVTGIEEFAEIESYSFSSMPSPHMSVENMLELSKFIKGLIDSDDCDGVVVTHGTDTLEETAYLLDLTLDTEKPVVITGAMRSSSELGYDGPSNLAASICTAISDDSKGRGVLVCFNGELNSAAEVTKANSMALNAFKTPNFGPIGIVDNNNVIFYRKTKKVCTYSVNNIEGDVALIKCVAGMNSDFIEFSLEKGSKGIVIEALGRGNVPPLMIEGIKKALVKNIPVVVVSRCFEGRVFESYGYEGGGKMLKDLGVIFGDTLPGQKARIKLMLAISAGLSIESIEKHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDT5</accession>
    <name>A0A386PDT5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00035</name>
        <name evidence="8" type="ORF">CP523_02945</name>
        <name evidence="9" type="ORF">CP523_06100</name>
        <name evidence="10" type="ORF">CP523_12155</name>
        <name evidence="11" type="ORF">CP523_14620</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32949">
        <property type="protein sequence ID" value="AYE32949"/>
        <property type="gene ID" value="CP523_00035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33494">
        <property type="protein sequence ID" value="AYE33494"/>
        <property type="gene ID" value="CP523_02945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34072">
        <property type="protein sequence ID" value="AYE34072"/>
        <property type="gene ID" value="CP523_06100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35107">
        <property type="protein sequence ID" value="AYE35107"/>
        <property type="gene ID" value="CP523_12155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35564">
        <property type="protein sequence ID" value="AYE35564"/>
        <property type="gene ID" value="CP523_14620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00035"/>
    <dbReference type="KEGG" id="csep:CP523_02945"/>
    <dbReference type="KEGG" id="csep:CP523_06100"/>
    <dbReference type="KEGG" id="csep:CP523_12155"/>
    <dbReference type="KEGG" id="csep:CP523_14620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="412" mass="47611" checksum="97B0A2504ED1C41B" modified="2018-12-05" version="1">MTRKIDTNFDYNEEIKRCKTIDDVMGKNGLIQRLVKDVLENILEGEMEEHLGRNKYERVEAVDQTKKNYRNGYSRKNLRSSFGDVDLDVPRDRNAEFEPQIIKKYETVCTELDKKIISLYAKGMSTSDIQAEIEDLYGITISPSMVSKITDKVLASAAEWQNRALDKIYPIVYLDAMYFKVRSNGKIVNKAVYICLGYTMEGYKDILGIWVDEAEGAKFWLGICNDLKNRGVKEILIACMDGLKGLPQAIKTVFPSVNIQTCIVHQIRNSIKYIASKDKKAFMKDLKEVYKATTEELALAQLDNLKERWGDKYGIVIDSWYNNWSNLSTFFDFSPTIRKMIYTTNILEGFNRQIRKFTKVRVIFPTDESLNKCVYLATMEILEKWTQPIHNWGATLAELSIIFEDQLKDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDV3</accession>
    <name>A0A386PDV3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06715</name>
        <name evidence="4" type="ORF">EI377_01185</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679136.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01563"/>
    <dbReference type="EnsemblBacteria" id="AYE34183">
        <property type="protein sequence ID" value="AYE34183"/>
        <property type="gene ID" value="CP523_06715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59547">
        <property type="protein sequence ID" value="QAS59547"/>
        <property type="gene ID" value="EI377_01185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="35702" checksum="5A88AAA1F74DF444" modified="2018-12-05" version="1">MSKMISIVVPMYFEEKVVEECYRRLTEVMSNIKYEHELVFVNDGSTDGTLPMLKDIASKDSSVKIIDFARNFGHQIAVTAGIKEAKGDAVIVIDADLQDPPELILEMVDKWENGYEVVYAKRKKRKGETFFKLMTAKYFYKFLQIMSDVDIPRDTGDYRLMDRKVVDVFNSMTEKNRFVRGMVSWLGFNQTYVEFVRAERFAGETKYPLKKMLKLAEDGIVSFSHKPMKIIGGFGVIFLVIFFLQILIAIYNSIFRFGVSDIFCLATYVSLVAGILLISLGVLGSYIARIFDESNGRPLYIIREKVNFDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE48</accession>
    <name>A0A386PE48_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00020</name>
        <name evidence="2" type="ORF">EI377_10505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32946">
        <property type="protein sequence ID" value="AYE32946"/>
        <property type="gene ID" value="CP523_00020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61119">
        <property type="protein sequence ID" value="QAS61119"/>
        <property type="gene ID" value="EI377_10505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="177" mass="21130" checksum="17F38B437D5585CE" modified="2018-12-05" version="1">MSLNEKYLEEKIKHLKKAIEIVGGNNLLENKFSNSEELLKYIVESAFKEEKIEFEVENKKFTIKALMEIKVQYEKHLIRSRSKVIQGITYKIKKYNTSLDSLVRKYKKSNNINEYNEIKNQIIKTYRMDINLYILKEINELIINDIRIADEIDFYGPYLSEKREQLIINIMRNIGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE52</accession>
    <name>A0A386PE52_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tim44 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04240</name>
        <name evidence="3" type="ORF">EI377_14765</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676502.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00428"/>
    <dbReference type="EnsemblBacteria" id="AYE33737">
        <property type="protein sequence ID" value="AYE33737"/>
        <property type="gene ID" value="CP523_04240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61894">
        <property type="protein sequence ID" value="QAS61894"/>
        <property type="gene ID" value="EI377_14765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tim44" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="124" mass="14813" checksum="5AB44590682A4EF3" modified="2018-12-05" version="1">MDVDISKNYMSDNIYNTHNTKLSWMKIRKQRNILENIKLISAKPIAIKHYKDNSKDVVWFAIKGSMIDYIINVNTNDMVEGSTKNKSFAEFWKFIKVKDKWVVDRIMQTYEVNLELDLQNRFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE55</accession>
    <name>A0A386PE55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RidA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03155</name>
        <name evidence="3" type="ORF">EI377_13670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677272.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02153"/>
    <dbReference type="EnsemblBacteria" id="AYE33534">
        <property type="protein sequence ID" value="AYE33534"/>
        <property type="gene ID" value="CP523_03155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61697">
        <property type="protein sequence ID" value="QAS61697"/>
        <property type="gene ID" value="EI377_13670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="126" mass="13748" checksum="832B13CC3460FF9B" modified="2018-12-05" version="1">MTREIISTEKAPQAIGPYSQGIKFGNMVFTSGQIPINPATGELITEIKEATKQSLENVKAILEEAGSSLDKVIKVGVFLNDMNDFAVVNEVYAKYFNNNKPARSCVEVARLPKDSVIEIEAIASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE98</accession>
    <name>A0A386PE98_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-siderophore ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07915</name>
        <name evidence="4" type="ORF">EI377_02675</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675892.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00698"/>
    <dbReference type="EnsemblBacteria" id="AYE34355">
        <property type="protein sequence ID" value="AYE34355"/>
        <property type="gene ID" value="CP523_07915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59759">
        <property type="protein sequence ID" value="QAS59759"/>
        <property type="gene ID" value="EI377_02675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362701" evidence="1">
        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="313" mass="34976" checksum="901991C009E9F695" modified="2018-12-05" version="1">MTKKILSMILSSMVATSLFVSCSNKVDKTSKDQTISIQHSMGTSEIPKTPERVVILTNEGTEALLTLGIKPVGAVTGVTGDWYEHNKNELDGVKPIGKEKAPNIEAIAALKPDLIIGNKMRHEKIYDQLNSIAPTVFSDTIRGAWKDNFKFYANVLNKESEGEKAIGKYENKITYIKENYKEKLDTKISLVRFMEGKTRIYLGDTFAGTILKEIGFKRPESQQGTEFVNEIGKERLKEADGDVMFYFTYELGDGKGLAREAEWMQDPLFKSLDSVKSNKAFKVDDTIWNTAGGIKAANLMLDDLTSMLKEGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED7</accession>
    <name>A0A386PED7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03590</name>
        <name evidence="6" type="ORF">EI377_14120</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677729.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02227"/>
    <dbReference type="EnsemblBacteria" id="AYE33614">
        <property type="protein sequence ID" value="AYE33614"/>
        <property type="gene ID" value="CP523_03590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61778">
        <property type="protein sequence ID" value="QAS61778"/>
        <property type="gene ID" value="EI377_14120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="494" mass="55841" checksum="7EC448FD240F5883" modified="2018-12-05" version="1">MNSNVFDVIVIGSGLGGLRSTQELLKNNLKVCMITSKEFCSGASFYPGTWGLGMIGPKDEEDKKNLLENILKVGCNKSNPKLSSILVDNVNDEIDLLLKEGVNFKRSIDSDGVVPCFDSNKRRWFGFDFPSAKKVFSKMLEDKNLTVLSKTKVIDIYNIKDSSKGVLVEYKDKSLDILKSKSIIIASGGYTCLFKHNFSLELNSPIVQYLAYKNGCELINLEYIQFIPAYIKPMYKTVFNERVFNYITLKDRDGNDILENIKDLNNLLKERSTYGPFTTRLKSNIIDKKLFEYYKKDNDSAYFEYPKNIEDIDDTLIYNYFKWLKDSKKNINDKIHIAPFAHACNGGLKIDENASTTVNGIFACGEVTGGVNGADRLGGLSTCNALVFGAIAGKNASKYCKTHEFEDFNIDTPFDIEATKEDLEKFKDILCKLRESLYLEASILRNKESILKAKKIINSLKDESKNINLSTANKAILESYINFSLIFLENIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED9</accession>
    <name>A0A386PED9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="14" type="ORF">CP523_08185</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674691.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01580"/>
    <dbReference type="EnsemblBacteria" id="AYE34405">
        <property type="protein sequence ID" value="AYE34405"/>
        <property type="gene ID" value="CP523_08185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="676"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="590"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1036" mass="119195" checksum="DFC6B1D14C3A491F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEG3</accession>
    <name>A0A386PEG3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I-B CRISPR-associated protein Cas8b1/Cst1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas8a1</name>
        <name evidence="2" type="ORF">CP523_01670</name>
        <name evidence="3" type="ORF">EI377_12190</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00886"/>
    <dbReference type="EnsemblBacteria" id="AYE33258">
        <property type="protein sequence ID" value="AYE33258"/>
        <property type="gene ID" value="CP523_01670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61429">
        <property type="protein sequence ID" value="QAS61429"/>
        <property type="gene ID" value="EI377_12190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019121">
        <property type="entry name" value="CRISPR-assoc_CXXC-CXXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010180">
        <property type="entry name" value="CRISPR-assoc_prot_CXXC-CXXC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09706">
        <property type="entry name" value="Cas_CXXC_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01908">
        <property type="entry name" value="cas_CXXC_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_CXXC_CXXC" evidence="1">
        <location>
            <begin position="224"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="563" mass="65604" checksum="54CFD6C7268AE6B0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ1</accession>
    <name>A0A386PEQ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="5" type="ORF">CP523_08895</name>
        <name evidence="6" type="ORF">EI377_03650</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876926.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34525">
        <property type="protein sequence ID" value="AYE34525"/>
        <property type="gene ID" value="CP523_08895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59927">
        <property type="protein sequence ID" value="QAS59927"/>
        <property type="gene ID" value="EI377_03650"/>
    </dbReference>
    <dbReference type="GeneID" id="66300440"/>
    <dbReference type="KEGG" id="csep:CP523_08895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="49" mass="6005" checksum="53C74487FDB0016B" modified="2018-12-05" version="1">MRVKITLACTECKQRNYNSMKNKKNNPDRLDMQKYCKFCKKHTLHRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET5</accession>
    <name>A0A386PET5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="4" type="ORF">CP523_02375</name>
        <name evidence="5" type="ORF">EI377_12895</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673982.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00492"/>
    <dbReference type="EnsemblBacteria" id="AYE33388">
        <property type="protein sequence ID" value="AYE33388"/>
        <property type="gene ID" value="CP523_02375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61560">
        <property type="protein sequence ID" value="QAS61560"/>
        <property type="gene ID" value="EI377_12895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02375"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="23734" checksum="59664FCDCCD9B8E0" modified="2018-12-05" version="1">MNKQDLARMIDHTLLKAEATEAQVEELCKEALEYKFASVCINPGMVKKAAEMLAGSEVKVCTVIGFPLGATTTAVKAFETEDAIKNGATEVDMVINIGKLKERDLEYVKNDIKAVVDAAKGKALSKVIIETCLLTDEEKVIACKLSKEVGADFVKTSTGFSTGGATAADIKLMRETVGPEMGVKASGAVRSQEDAMTMIENGATRIGASASIAICEGKVSNSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU2</accession>
    <name>A0A386PEU2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05440</name>
        <name evidence="4" type="ORF">EI377_16000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677960.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02580"/>
    <dbReference type="EnsemblBacteria" id="AYE33957">
        <property type="protein sequence ID" value="AYE33957"/>
        <property type="gene ID" value="CP523_05440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62108">
        <property type="protein sequence ID" value="QAS62108"/>
        <property type="gene ID" value="EI377_16000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
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        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362747" evidence="1">
        <location>
            <begin position="31"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="349"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="482" mass="54633" checksum="702E19391F8D74A1" modified="2018-12-05" version="1">MKRVKKLLALVTCGVLATSLALTGCGNSSTSDKKDGETVNLTWYTIGQEPKDLSLVEDEINKYLKDKINATIDMKFADFGDYDQKLSVVINSGEAFDLAFTCSWAGNYVGNARKGAFLELDSYLDTTGKDMKNEIDERFWNGAKVEGKTYAVPNQKELGVQPMWVFTKELVDKYNIPYQDIKDLEDLEPWLKLIKEKEPDVVPLYIDKNLSPPQYFDMFSEPFGIEYADESLTVKNIFDTDKFKSTLKTLRKYYELGYINTDGAIAKYDKTVKRFVTKADGQPYAEGLWAKDVGYPLVATPIMDTYITSASTTGSMIAVSKNSKNPEKAVEFLNLLNTDEKLRNLVNYGVEGTHYEKVGDKQVKLLPRSIDYSVAYFSVGNLFKTDVLDTEPTSKWEEFEEFNKNSKVSPALGFKFNPEPVSTQIAGISNAYQEFRALIFSGSVDIDEYIDKLNTKLKEQGMDDVIKEMQKQVDEWKKENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU7</accession>
    <name>A0A386PEU7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">S4 domain-containing protein YaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaaA</name>
        <name evidence="1" type="ORF">CP523_07675</name>
        <name evidence="2" type="ORF">EI377_02365</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673867.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01144"/>
    <dbReference type="EnsemblBacteria" id="AYE34330">
        <property type="protein sequence ID" value="AYE34330"/>
        <property type="gene ID" value="CP523_07675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59726">
        <property type="protein sequence ID" value="QAS59726"/>
        <property type="gene ID" value="EI377_02365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014330">
        <property type="entry name" value="RNA-bd_S4-rel_YaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02988">
        <property type="entry name" value="YaaA_near_RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7737" checksum="AD1B48CB5111DEA8" modified="2018-12-05" version="1">MQEIKINTEFIKLDSFLKWCGVASLGSEAKIYVLEEMVKVNGEVCTQRGKKIRPGDVVEFEGEKFKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF28</accession>
    <name>A0A386PF28_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV DNA damage repair endonuclease UvsE</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">UV damage repair endonuclease UvsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">uvdE</name>
        <name evidence="8" type="synonym">uvsE</name>
        <name evidence="7" type="ORF">CP523_02850</name>
        <name evidence="8" type="ORF">EI377_13375</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677001.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00976"/>
    <dbReference type="EnsemblBacteria" id="AYE33478">
        <property type="protein sequence ID" value="AYE33478"/>
        <property type="gene ID" value="CP523_02850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61649">
        <property type="protein sequence ID" value="QAS61649"/>
        <property type="gene ID" value="EI377_13375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="PTHR31290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="413" mass="48764" checksum="1F496573AE0593DF" modified="2018-12-05" version="1">MKIGYACTPLLVPYKTTRRISLKYYSEKLLIDTIKENLNDLLRILSYNRDKEIKMFRISSDIIPLGSHPINTFDWNNYFQYELNNIGKFIKNNSMRVSMHPGQYTVINSPKEDVVKKSILDLQYHAKFLDSLGIDSSHKIILHIGGVYGDKELAIKRFMNVFKDLDKNIKNRLVIENDEKNFSIDDVLFIGENLSIPVVFDNLHNECFNDNNYSISNILKRVKKTWNKKDGNIKVHYSQQNPLKKLGAHSQSLNITNFLYYLDLCKDFELDIMLEVKDKNISAIKAVNSILELSNALLKENIDTEFKNYKFILLEQGENILYEGYNILNKNTSLIEFYKFIDSFMYNEILVENKTHVLKLLENELKSYMTSKESNHFYKLLKERNFNKCKEYLYKIACKYHIELSKNYYFYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF32</accession>
    <name>A0A386PF32_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">purH</name>
        <name evidence="10" type="ORF">CP523_01765</name>
        <name evidence="11" type="ORF">EI377_12285</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677325.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02398"/>
    <dbReference type="EnsemblBacteria" id="AYE33276">
        <property type="protein sequence ID" value="AYE33276"/>
        <property type="gene ID" value="CP523_01765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61447">
        <property type="protein sequence ID" value="QAS61447"/>
        <property type="gene ID" value="EI377_12285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01765"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="500" mass="55943" checksum="BCA9F6FFFBCFF695" modified="2018-12-05" version="1">MIKRALISVFDKEGILDFSNFLSAKGVEIISTGGTFKHLKENGVNVTEVNEVTNFPEMLDGRVKTLHPILHAGILAIRDNEEHMNTIKERNIEPIDMVIVNLYPFFKKVREDLSFDEKIEFIDIGGPTMLRAAAKNFKDVAVISDKEDYKVVREEIEALGEVSFKLRKKLAGKVFNLMSAYDAAISNFLLEDEEYPEYLSISYKKLQSLRYGENPHQSAAYYGRTEIDGAMNSFEVLNGKELSYNNIKDLDIAWKVVCEFEEIACCGLKHNTPCGVAIGETPFEVYTKAYNADPTSIFGGIVAINRKIDKATAEEMVKIFLEVVAAPDFDEDALEVLKTKKNLRVIKCNNTPQDKKFMVTVDGGMLVQEEDKKLVEEIKVVTEKVPTEEEMRDLVFGMKVVKYVKSNAIVTIKDGVAVGIGGGQVNRIWPTEDALRRGKGATVLASDAFFPFRDVVDTCAKHGIKAIIQPGGSMRDEESIEACNEHGIAMVFTGIRHFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC5</accession>
    <name>A0A386PFC5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01370</name>
        <name evidence="3" type="ORF">EI377_11880</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675582.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33202">
        <property type="protein sequence ID" value="AYE33202"/>
        <property type="gene ID" value="CP523_01370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61374">
        <property type="protein sequence ID" value="QAS61374"/>
        <property type="gene ID" value="EI377_11880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="442" mass="48485" checksum="E44F5974E07569A8" modified="2018-12-05" version="1">MKKIDLTEGNVRDVIIALALPIMGSSLLQLTYNLVDMLWVGGLGSDSVASIGTSSFFIGLGHSINSLVVIGTGIKVAHSIGEKNEREVKEYLNSGLFLNLIIGIIYSTIIIVTGKKLIGFFDLNNPIVEKNGYLYLAFSAPTLLFTFFNILYIRVLSSFGNNKSALKISALGIIINIILDPILIYSFKMGVLGAAIATLLSNILMFILFNIKGKEMLTFDLSVGIRKENIIKIARLGFPMAFQRVLFTFVNIVLAKIISNFGSDAIAAQKIGLQIESIMLMVVGGLNGAVSSFVGQNYGAKRNDRVIKGYNISLLIGTIYAAVASIIFIIFPEFLVKLFVREKETIIIGSSYLRIVGLSQVFAAIEMISNGMFTGIGKPKIPAFISMIFTVLRIPMALFLIKGLGINGVWISISVSSILKGITAYLMYRYKIWRSYKNVIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG2</accession>
    <name>A0A386PFG2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10415</name>
        <name evidence="3" type="ORF">EI377_05185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674234.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01417"/>
    <dbReference type="EnsemblBacteria" id="AYE34783">
        <property type="protein sequence ID" value="AYE34783"/>
        <property type="gene ID" value="CP523_10415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60178">
        <property type="protein sequence ID" value="QAS60178"/>
        <property type="gene ID" value="EI377_05185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788379" evidence="1">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="304" mass="35220" checksum="D27139FE3856D666" modified="2018-12-05" version="1">MKKLTYILVIVTLGLFMGLGIFSSPLLVNATNEFDKEREVFLNITTVSKPQYYMVKSLVGDKHNVEYLFSTEEEIEKFKVDENIINNVSNIDLFIYTGLNYEPWINNLIDNLKKGSIGVINISRGVRPLGYEVNNSAKENPYYFLGYNEYKIALYNIKQSLQERDIKNKDFYEANYNKKIEELNGIIEPLKKEIGKHKNYTVIVNTDEFDYLLKDLGINFIKIKGEPSKRSIDGKILNESNIVFIKDKSKPMKETEESTDISNEEKLKYDTVELIKFDGKISFDELMINNIKLIADTLKKLPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI5</accession>
    <name>A0A386PFI5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mreC</name>
        <name evidence="7" type="ORF">CP523_10590</name>
        <name evidence="8" type="ORF">EI377_05375</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674176.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01383"/>
    <dbReference type="EnsemblBacteria" id="AYE34813">
        <property type="protein sequence ID" value="AYE34813"/>
        <property type="gene ID" value="CP523_10590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60207">
        <property type="protein sequence ID" value="QAS60207"/>
        <property type="gene ID" value="EI377_05375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="283" mass="31488" checksum="ABDFD67418600BA8" modified="2018-12-05" version="1">MKLFKNKLAVTIIVLSVAFLGIIMYTVNSQQKDIVSSGVGTVIGPLQKIVYKVNDKIKGSLSFVFNFSKVKEENEELTKKNIDLENKLLEYEKLKDENNRLRDILNFKNSKNNYDYLGCEIIGHSGGNITNGYIIDKGENNGLKKGMVVISDKGLVGQVTSTGSNWAIVESLVNENIAVSVMVNSTRETTGILKGYKDHSNQNLTQVTNLPMDSAIKEGDVIVTSGLGKVYPREIRIGEVVSVETDNVKVMKSAIVKPYVDFNKLEELFVIIPKETRDVKYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ0</accession>
    <name>A0A386PFJ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02635</name>
        <name evidence="7" type="ORF">EI377_13170</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673895.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00440"/>
    <dbReference type="EnsemblBacteria" id="AYE33436">
        <property type="protein sequence ID" value="AYE33436"/>
        <property type="gene ID" value="CP523_02635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61610">
        <property type="protein sequence ID" value="QAS61610"/>
        <property type="gene ID" value="EI377_13170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="197"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="31834" checksum="B1F5E5DE2A457EDC" modified="2018-12-05" version="1">MRLNQNIASLNIYKNYKRNLKLQSASLEKISTGNKINKAKDDPNKLGMSEGLRMQIRGIQSAEKNLQDGSSMMQSVEGSLSSITEMLLRMKELVIQGSNGTNSDADLQTIQAEIVQIKENIDFTANTSDFNGVNLLHNENVDNNNYPGYKTHMVGANSGEELQVPLFNISTNILKDKDGNNVKNIDVTDRDKVNKNISAIDSAISIVNDVRSKYGAIQSRMETSYENLISTSSTLQKSESKVRDADIALEMVEYSRTSVLHNSALSILNQSNNFPQDVLRILERIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK3</accession>
    <name>A0A386PFK3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FadR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_05855</name>
        <name evidence="7" type="ORF">EI377_00340</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01874"/>
    <dbReference type="EnsemblBacteria" id="AYE34024">
        <property type="protein sequence ID" value="AYE34024"/>
        <property type="gene ID" value="CP523_05855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59396">
        <property type="protein sequence ID" value="QAS59396"/>
        <property type="gene ID" value="EI377_00340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="26295" checksum="BCDA7F55AAF6985F" modified="2018-12-05" version="1">MFNQVKNTKVYEQIVDQIKAMVEDGTLKKGDKLPTERVMAEDLGVSRASVREALRALEVVGLIESRQGAGNYIKENFGGLLSEPLAIMFMLQESNPLDIYELREVIELETVILATRKRSDEHLEKIKNILDELKENVDEDNNVVLDKEFHYTIAAASGNKLIIDVLEVLSQLIDKFIKVSRKNILSDAENKWDLLSLHEKLYEAIRDRNEVSAHAIMKDHFELIKRYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP9</accession>
    <name>A0A386PFP9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10900</name>
        <name evidence="4" type="ORF">EI377_05695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677639.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02514"/>
    <dbReference type="EnsemblBacteria" id="AYE34873">
        <property type="protein sequence ID" value="AYE34873"/>
        <property type="gene ID" value="CP523_10900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60268">
        <property type="protein sequence ID" value="QAS60268"/>
        <property type="gene ID" value="EI377_05695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="106"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="398" mass="43903" checksum="70893C1614569FD4" modified="2018-12-05" version="1">MKLLSIGAGKEQIYSIKKAIEKGHYVIAIDGNKESEGFKLANEYSVVDISKENEVIEFAKKNNIEGILQVPIGRFLSTIGAVNDSLNLKGISKEAALNCVNKTKTNEILFHNNIGCAGQITLKTFDNMELINKINDFGLPCVIKPKFGSGSSGVRIINNKAEVEKMVAEHLEENLTGEVIIEELLEGIEYGVDFVVIDNSGYLVLVREKELTDIPFRQEVAFIGPANLEDIIYDKVFNIMDKATKALGINNTLVHADIMIKDNEVKIIEISGRPSGLLLSSKIVPLSTGLDYLGLGVDIVTSNISKDLNLTNLEKNCVGISFFNLNEGKVVDITDISEMLKGNVIEYINNININDELTIIKKGKDLIDRGHVIVKGKTVDEVKLLFKNILQNIKIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ1</accession>
    <name>A0A386PFQ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07240</name>
        <name evidence="2" type="ORF">EI377_01995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673741.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01065"/>
    <dbReference type="EnsemblBacteria" id="AYE34257">
        <property type="protein sequence ID" value="AYE34257"/>
        <property type="gene ID" value="CP523_07240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59664">
        <property type="protein sequence ID" value="QAS59664"/>
        <property type="gene ID" value="EI377_01995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="207" mass="23838" checksum="BD4FEE8D1D77D35A" modified="2018-12-05" version="1">MRYLHVVFDIDGTLIDSEKAVLKSLQKTLLEVKGVNVNLSDLKFALGIPGRDALLKLNIGNLEQVENMWNEYYNDYLDDIKLFNGIREVIEELKSKSIKLGIITSKTRKEYETDFMRFELDDYFDVVICADDTLKHKPDGEPMEKYLKIANAKKEETIYIGDSIYDMQCAKNAEVDSILALWGREDLDTLKATYKLNSPKDILEIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR8</accession>
    <name>A0A386PFR8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34277">
        <property type="protein sequence ID" value="AYE34277"/>
        <property type="gene ID" value="CP523_07345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="112" mass="12587" checksum="328352FA8D57C434" modified="2018-12-05" version="1">MKKVYKESQLVELNNIPLEVIENIRGTISILSEAYGADRDIEADLGGYIVIAENIVDIEFLKQNKLQGLIQEYTDVIKSSEGVDWTSSLFLLSSDYAIVVVTTEELSKFLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT1</accession>
    <name>A0A386PFT1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_04190</name>
        <name evidence="11" type="ORF">EI377_14715</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676853.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02747"/>
    <dbReference type="EnsemblBacteria" id="AYE33728">
        <property type="protein sequence ID" value="AYE33728"/>
        <property type="gene ID" value="CP523_04190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61885">
        <property type="protein sequence ID" value="QAS61885"/>
        <property type="gene ID" value="EI377_14715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="280"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="481" mass="53588" checksum="E8A1FF00D28C3142" modified="2018-12-05" version="1">MKKRVGVIILLLIMIGILLGGINLFFKNKSNSARRIVVGTSGTYYPFTFSDGDRVSGFEIDLWNEIGKRLNYDIEYKTASFSGLFGLLDSKKVNVISNQITVTDERKKKYYFSEPYVESGAQIIIKNDYEGKIESFEDLKGKKVGVDLGSNYENLLRGKDKSNEIDIVTYQSTDSAFNDLMIGRIDAVVIDKISAVININEKNLPLKLAGEPFEKVVNAFPFIKNDENLEFIKTLNNVLDDMKNDGTLQQISNKWLNIDVVSYNSDSFFNRLIKGIFSGAKTTLALGIISMIIGLIIGTIISIIKNLKVIGLTQILSIYVSFFRGTPVLVQLFLLYFGLPQIFPALKGMSAFTAAYIGLGLNASAYIAEALRAGFETVDKGQLEAALAIGMTRIQATKRIILPQVFRMSIPSLGNIYIDVIKGSSLAFTLGVTEILAKSQMLAAASYRFFESYIAVAIIYWVLIGIFNYLQRILEKRLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT6</accession>
    <name>A0A386PFT6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-[acyl-carrier-protein] thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_07500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673798.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01109"/>
    <dbReference type="EnsemblBacteria" id="AYE34297">
        <property type="protein sequence ID" value="AYE34297"/>
        <property type="gene ID" value="CP523_07500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="249" mass="29401" checksum="4F5C76AF700A47ED" modified="2018-12-05" version="1">MGEQYSKDYQVHFYEADYNLDCTMTSIINILGDVGTEQSEKLGVGINYLVDKNMAWVFYQYDVKIIRYPKYGEKLKAVTVAKGFKKFYAIREYSIYDEDGNKVVEAQAIFFLINIEKRKTMRIPEEQYKAYGLESDIKEPFKIERLEKLQESTYEKEFKIRYSDIDFNRHVNNAKYVEWAIESLPIEVVRNFKLENIKVTFEKECTYGEEIRALSSVRKEEDGSLISIHRIESKDGIELTKLIGKWMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG38</accession>
    <name>A0A386PG38_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Thiamine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02935</name>
        <name evidence="7" type="ORF">EI377_13460</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00993"/>
    <dbReference type="EnsemblBacteria" id="AYE33492">
        <property type="protein sequence ID" value="AYE33492"/>
        <property type="gene ID" value="CP523_02935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61663">
        <property type="protein sequence ID" value="QAS61663"/>
        <property type="gene ID" value="EI377_13460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="333"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="552"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="638" mass="73320" checksum="F926521DBC4DC649" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG62</accession>
    <name>A0A386PG62_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679067.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34001">
        <property type="protein sequence ID" value="AYE34001"/>
        <property type="gene ID" value="CP523_05725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="115" mass="13536" checksum="FF60966DEEB65F5D" modified="2018-12-05" version="1">MQLNDTQKMAINVSDYLEKNLAGKIGSCDIFNVIDDRNYRAFSIRFKAYDYFIVLFNYDKGVIGCSIQYGENSFISLENSQKWYEKADFDVFCKELKKQLELRIPDKFLEANGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG5</accession>
    <name>A0A386PGG5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04295</name>
        <name evidence="6" type="ORF">EI377_14825</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00419"/>
    <dbReference type="EnsemblBacteria" id="AYE33746">
        <property type="protein sequence ID" value="AYE33746"/>
        <property type="gene ID" value="CP523_04295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61902">
        <property type="protein sequence ID" value="QAS61902"/>
        <property type="gene ID" value="EI377_14825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="396"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="479" mass="54351" checksum="1A46193F8C2793F3" modified="2018-12-05" version="1">MKSVWSESCKFKKRETLKEDIKTDILIIGAGITGLLTAHMLKKSGRNVILIDGDEIASGNTKNTTAKITSQHDLIYNKLILEFGEEKARQYAKANELAIEKYKEIIKERKIDCDFEDKAAYIYSLNEIGILKEEVEAAKKVGIDAEFVEKANLPFEIKGAVKFNNQGQFNPLKFLKNISEDLIIYENTRALEVKDNLVVTNRGDITANSIVIATHYPIINMPGYYFMKMHQERSYVIALENVNDIDGMYIDVDKEGYSFRTYKNLLLLGGIKQRTGENEKGGSYDELRRVAKELYPKSRERYHWSAQDCMTIDGIPYIGKYSDETPNIYVATGFNKWGMTSSMVAAMIISDMILEKENDFSEIFSPKRFDLSLSINNIAKDISETAKNFIAQKIYIPSSKIEHIKNGHAGIIEYNGEKVGVYKDNEGKEFFVSTKCSHLGCQLHWNADELTWDCPCHGSRFDYKGRLIGGPATKGLVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP0</accession>
    <name>A0A386PGP0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12815</name>
        <name evidence="10" type="ORF">EI377_07690</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02800"/>
    <dbReference type="EnsemblBacteria" id="AYE35233">
        <property type="protein sequence ID" value="AYE35233"/>
        <property type="gene ID" value="CP523_12815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60628">
        <property type="protein sequence ID" value="QAS60628"/>
        <property type="gene ID" value="EI377_07690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR022216">
        <property type="entry name" value="ABC_Co_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12558">
        <property type="entry name" value="DUF3744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="302"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="7">
        <location>
            <begin position="335"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60628.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="567" mass="63845" checksum="779DCC71F6DC97D5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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                <person name="Seyboldt C."/>
            </authorList>
        </citation>
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            <strain evidence="4">DSM 7534</strain>
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                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="7"/>
            <end position="28"/>
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            <dbReference type="EMBL" id="QAS60746.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="107" mass="12542" checksum="9165200DF234AE67" modified="2018-12-05" version="1">MSNIKKTLKYIVTILGILFLGSLGLHGYNMGRLMYTDLDVLKIPYIDKYYVAIGEKDDATDVFKKYMADNNWQFIENISEILIFRKGNIQKEVHLDNLKEIKKNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ8</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="314" mass="35879" checksum="55E1CF266E56C34F" modified="2018-12-05" version="1">MAKFIVVKKNFILSSLVALVVICTLFFSFYKLNRNIKTATTFLSTLTNGDGITQDFDGDGENETIEIQKEKGYYIIKIKGKNKELTLKDKNDCETIASICNNWPLKIDVLDLSRDGIPEIIVRGSKDNLPVNYIFTWQNENFHNIYSSTDNILGILDSTNSRTPKFLSLSSSKGDNSTNAYIFNGDVLKDISFSKPIVPGLNSVQSFIDLIQVQYEISDPPNIFTSEIPSNELSLLWNLDKETYRYDFQNGYFHDVNWDESGEVLSLIWCLSFQQVKIQDPDNNRKEALIYITIKKDDYKNFKISSIKKTLSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH04</accession>
    <name>A0A386PH04_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spoVB</name>
        <name evidence="8" type="ORF">CP523_11950</name>
        <name evidence="9" type="ORF">EI377_06770</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673459.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02948"/>
    <dbReference type="EnsemblBacteria" id="AYE35070">
        <property type="protein sequence ID" value="AYE35070"/>
        <property type="gene ID" value="CP523_11950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60463">
        <property type="protein sequence ID" value="QAS60463"/>
        <property type="gene ID" value="EI377_06770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014249">
        <property type="entry name" value="Spore_V_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02900">
        <property type="entry name" value="spore_V_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="357"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="499" mass="54995" checksum="3A8CAB3D7EB92F28" modified="2018-12-05" version="1">MGKDNFVKNSFLLTTSNITTGILGFIFSIYLSNLIGPKGMGLYSLVMPVYNLFICLMTAGIIAAISQVSAVYSAKGEYNNIKKTMRSVAIFNIIWAVIIGVIVFLFSPIISKYGVNDVRTVNAIRVTCPAMVFIALSNILKGYFYGVSKITLPSLIDILEKAMRVLTLALLIFMFKTTTLEGLVTLAYVSLAIGELQSLLLLFGYYRHISKKTPITRDKPERASQLLFNVFIIAFPLCINGFLGNLFATASTLIVPRRLMVAGFDYSTALGLIGKFTGMALTIISFPMIVVSSINSLIIPDLSQTLSKGDYYNACVRIKKVMKIAFLLGLATTIICNIIPDSLGNMFYNRDDLGTYIKISSLCAPILFTSTTMFGILNGLNRQGIILRNSLIVASVELISLFIFTSIPNINILGYAITMFITSTLSLIINLHEVKKHLDLNLSKTNITIFLLLSVLVFMLLNLLANTLLKDLFIIKNIIICLLSFGIFAILSFFGVIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH35</accession>
    <name>A0A386PH35_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase subunit GlgD</fullName>
            <ecNumber evidence="4">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgD</name>
        <name evidence="3" type="ORF">CP523_06870</name>
        <name evidence="4" type="ORF">EI377_01355</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679170.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00039"/>
    <dbReference type="EnsemblBacteria" id="AYE34198">
        <property type="protein sequence ID" value="AYE34198"/>
        <property type="gene ID" value="CP523_06870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59563">
        <property type="protein sequence ID" value="QAS59563"/>
        <property type="gene ID" value="EI377_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="369" mass="41873" checksum="FFC1994F19EF7C18" modified="2018-12-05" version="1">MNSCLGIINLDENDSKMGNLVSNRVLASIPIAGRYRIIDFILSNMTNSGIEAIGVFTKNKSRSLIDHLSNGRPWDLHRKKDGLRVFNFGNDDPVYDDVHNFESNIEFIKKSRREYVLIAPSYMICNINYNDLIKYHKRLDNDITVVYKKISDANNNFIDCEILNINNKNRVIGIENNIGHENNANVNMEMYILKTDLFIDIIYEGIRSGLYKKVKEFIHLNIDNLKVGAFEFSGYLSCINSIQSYFNANLNFLKEEVNKELFHSNVPIYTKVQDEFPTKYTDGSKVNNSIVANGSYIEGTVKNCIIGRQVKIGKGSVIKNCIIMQNTVIGDNVIMDNVISDKGIVISNDNIIRGEGSLPITIEKEKAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH41</accession>
    <name>A0A386PH41_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13785</name>
        <name evidence="4" type="ORF">EI377_08675</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677142.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35415">
        <property type="protein sequence ID" value="AYE35415"/>
        <property type="gene ID" value="CP523_13785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60803">
        <property type="protein sequence ID" value="QAS60803"/>
        <property type="gene ID" value="EI377_08675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="36987" checksum="555121DC044735CF" modified="2018-12-05" version="1">MGKTVRKYYFDNLKGFLIICVIIGNSLELANPTSVNVHTFILLLYIFHMPMFAFVSGYFSKISKRSTKERVIDTTKLYLSAQIFYTFFNFLILKKSSVRLELLMPQWTLWYLLSMIFWYIISDYILDYKKWLMGSVCLSLIIGLDGSIGTIASVSRTVFFLPFFIIGRTFKEDYIEKLKKHKSKFVILTIVVLISLIKLSDETPIELLFEYTNYTWYFEKPWFPMFIRVFHYISSIIIGGFILTVIPIKITNITILGENSLIMYISHSGIVQLLLDFDIIKYNSLFSIVISTIIVILTVIIFTLIIVNVRLIKRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH60</accession>
    <name>A0A386PH60_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR02206 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12270</name>
        <name evidence="3" type="ORF">EI377_07095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673599.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03010"/>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000288332"/>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 6">VAT12</strain>
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    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="655" mass="69467" checksum="2B2D0498DB6AD602" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">VAT12</strain>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="178" mass="21065" checksum="78C6DC3228B7F8F1" modified="2018-12-05" version="1">MKYYLVALFDEESYKNLNPVQRNLSKKFRANRNSPSPYIPLEVVDNPNMDKLDLIIDKITKPYKNFKIQMCNQVSISEYNKTINLKIEDRGYIKRLNRLINDTLKLHGFNIKNFNNEIPMHISIANLNFIPKDMKRTDGEINLKSKSDILKVNRIELWKMSSNKKETLIKTYHLKQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH8</accession>
    <name>A0A386PHH8_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06020</name>
        <name evidence="4" type="ORF">EI377_00500</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675078.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01905"/>
    <dbReference type="EnsemblBacteria" id="AYE34056">
        <property type="protein sequence ID" value="AYE34056"/>
        <property type="gene ID" value="CP523_06020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59427">
        <property type="protein sequence ID" value="QAS59427"/>
        <property type="gene ID" value="EI377_00500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="121"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="278" mass="30635" checksum="0998294BC72B44E5" modified="2018-12-05" version="1">MSCIFKIKEGFNSFTNTEKKLAEYILNNSKKVVSLSAQELAKNANISPAAVVRFSKSLGYKGFTALKVDLARNSGENEKEIDITIEPDESTEAIVKKIGKSNTNTIKETLNLINIEKISSAIDILCNAKNIYLFGIGASGLVAIDFQYKLLRINKQVVYQNDPHIQLASSVHIGSGDVALGISYGGESKEVNLGIKKAKENGAKTIAITKYNKNTLSKLGDIVLYLPNEEKELRLGAISSRIAALTLTDILFLGIAREDFYTMEEHLIDTREMIQQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ8</accession>
    <name>A0A386PHJ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14560</name>
        <name evidence="2" type="ORF">EI377_09530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678674.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00200"/>
    <dbReference type="EnsemblBacteria" id="AYE35553">
        <property type="protein sequence ID" value="AYE35553"/>
        <property type="gene ID" value="CP523_14560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60939">
        <property type="protein sequence ID" value="QAS60939"/>
        <property type="gene ID" value="EI377_09530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="26651" checksum="3602046C5E8D63C1" modified="2018-12-05" version="1">MFCFIDYRTTKIERENLQRLDFNCIEIPKCKNLYPAIDGHVDIQLNILNIKSKEVIIHKDIDESFKLNLLKQGISYIETNNSLSPKYPNDVLINALILDNYFIHNLKFTDSNLLKTQDNKIKIHVKQGYTKCSCLPINEKALITNDTSIYKELTKNDFDVLLLPPGDISLPGLNYGFIGGTGGMISKNTIAFFGSLDNYLYGEKVKSFLYKYDVYPIYLSEGKLNDRGSLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP2</accession>
    <name>A0A386PHP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_06210</name>
        <name evidence="10" type="ORF">EI377_00685</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34092">
        <property type="protein sequence ID" value="AYE34092"/>
        <property type="gene ID" value="CP523_06210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59460">
        <property type="protein sequence ID" value="QAS59460"/>
        <property type="gene ID" value="EI377_00685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="13"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="401" mass="43938" checksum="927BCEB90C268110" modified="2018-12-05" version="1">MNIKEFVLFKKRELLQFCIYRLIFGISYSFMIPAIPLFFNSIGIATTMIGVVMSLYGVSKALAQIPFGFVSDKIGDKLLLIIAVGLMAFIPMGYVFFNTQLLVSGVYVLQGAILGMAAPATVSILARSLDESKRGECTGFASAVFTLGGGIGAAIAGFIISKFGNYNTVFYITSIGILLTFLFIIFRIKKSNISGSNKKSNKKGIKLIINDIKKYKLGYKIVLLSFIAMLGDFIYGCVVSIFPFYGKEVLGASVGYISIIISLYLFIFGFGAPLAGWVSDKIGNKKQLYLSFIVMNLTLFTLYLIRTKILFAAIIIVYFLGATFLNASLQSLLSEFGENENIKGIVFGVVGASESIGYAIGPIASAYIYELNKNWLFLGLLIVSILVLGIYHFLHKKAQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP4</accession>
    <name>A0A386PHP4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">galU</name>
        <name evidence="6" type="ORF">CP523_11020</name>
        <name evidence="7" type="ORF">EI377_05815</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677113.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00935"/>
    <dbReference type="EnsemblBacteria" id="AYE34897">
        <property type="protein sequence ID" value="AYE34897"/>
        <property type="gene ID" value="CP523_11020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60292">
        <property type="protein sequence ID" value="QAS60292"/>
        <property type="gene ID" value="EI377_05815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="32737" checksum="DDC27C687B53DF94" modified="2018-12-05" version="1">MKVRKAIIPAAGLGTRFLPATKAQPKEMLPIVDKPTIQYIIEEAIASGIEEILIITGRNKKCIEDHFDKSVELEMELAKNHKEELLELVRDISDMVDIHYIRQKEPRGLGHAIYCAKAFVGNEPFAVLLGDDVVDSQKPCLKQLMDCYSEYKTSILGVQTVNSEDVNKYGIVDGIHIEDRVYKVKDLVEKPAIEEAPSNVAILGRYIITPKIFEILENTKPGKGNEIQLTDALKTLIGNEAMYAYNFEGRRYDVGDKLGFLQATVEYALKKEELRESFIEYLSSKPWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ3</accession>
    <name>A0A386PHQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06325</name>
        <name evidence="3" type="ORF">EI377_00795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677768.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02424"/>
    <dbReference type="EnsemblBacteria" id="AYE34112">
        <property type="protein sequence ID" value="AYE34112"/>
        <property type="gene ID" value="CP523_06325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59478">
        <property type="protein sequence ID" value="QAS59478"/>
        <property type="gene ID" value="EI377_00795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="120" mass="13305" checksum="1E5E4712B7D9BAD9" modified="2018-12-05" version="1">MSNLNCKSSKCKYNHSGICNADYINVSGKYAHSSNETCCNTFKEGSIKNTFNTLNNIGIFNGVKQIFSDNTQGLRKEIYCDASNCYHNTNGLCKAENVLVSGSRARTLDETNCETFIEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR2</accession>
    <name>A0A386PHR2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11070</name>
        <name evidence="3" type="ORF">EI377_05860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00926"/>
    <dbReference type="EnsemblBacteria" id="AYE34907">
        <property type="protein sequence ID" value="AYE34907"/>
        <property type="gene ID" value="CP523_11070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60301">
        <property type="protein sequence ID" value="QAS60301"/>
        <property type="gene ID" value="EI377_05860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="380" mass="43356" checksum="36DC7487FD17980E" modified="2018-12-05" version="1">MDNKKIMSIIKREEGIKLDFKLKLSLNCESGKKELAKDICAIANSNGGRGYIIVGIQDKTKKIVGLRNEDLFSEEQVQQIISSRCEPPIPISVDIYNIQEKKICIITIYDGDQKPYQIRETGSFYIRRGSTTDTMRKQELVAAFQESLDFSIETCPIIKSNIEFLNIDIVSKYFQNKGIYISKDNKKFLLESAGITYIDKESGEEKCTLGGLLVFSDNNSICIPQNMIRIIDRTDIFSVNVIQGNLLDIIDKSEVLLKELLPSKYPIEAVVEGIKNAVLYREYSAINKIIEVVISYNSVLIISPGKMIEENIRGQKINYNKRNMWIYEKLMTLDNNKRLLNNGKGFTRMRNAFKGKGKVKFINSKTDDSFKVILPGVKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR3</accession>
    <name>A0A386PHR3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease M5</fullName>
            <ecNumber evidence="9">3.1.26.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNase M5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA terminal maturase M5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">rnmV</name>
        <name evidence="11" type="ORF">CP523_08305</name>
        <name evidence="12" type="ORF">EI377_03050</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ribonuclease M5 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.8" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674747.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01602"/>
    <dbReference type="EnsemblBacteria" id="AYE34428">
        <property type="protein sequence ID" value="AYE34428"/>
        <property type="gene ID" value="CP523_08305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59831">
        <property type="protein sequence ID" value="QAS59831"/>
        <property type="gene ID" value="EI377_03050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043822">
        <property type="term" value="F:ribonuclease M5 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01027">
        <property type="entry name" value="TOPRIM_RNase_M5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01469">
        <property type="entry name" value="RNase_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_M5"/>
    </dbReference>
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        <property type="entry name" value="RNase_M5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034141">
        <property type="entry name" value="TOPRIM_RNase_M5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13331">
        <property type="entry name" value="DUF4093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5S_RNA_mat_M5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="184" mass="20565" checksum="4AE3EAAB30280959" modified="2018-12-05" version="1">MIKEVIVVEGRDDITAVKQAVDAEVIAVGGFGINAKVIDRIKEAQKRKGVIVLTDPDFAGEKIRSIISKRVKGIKHAYIAQEDGIKGDDIGVENAKPEVIIEALNRAKISEEVIEEFYTSQDMFYFKLTGDTNSKQRRIMLGKELGIGYGNANQMLTRLNKYSITKEEFITAIQKIDKEMEGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR5</accession>
    <name>A0A386PHR5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15110</name>
        <name evidence="3" type="ORF">EI377_10070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676002.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01262"/>
    <dbReference type="EnsemblBacteria" id="AYE35655">
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        <property type="gene ID" value="CP523_15110"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61042"/>
        <property type="gene ID" value="EI377_10070"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788406" evidence="1">
        <location>
            <begin position="26"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="53956" checksum="886579A529527DF7" modified="2018-12-05" version="1">MRKKIFLSCIIICCISFCFSCTSNTNTLTDESKEKITEIVIARFTNIANDDSINKFNKILKDNNIPYSLKFIQYAKTNEDGTITNYKPGTYMESVEKDKNKIDLFVTNNAFETDFDYLDMIKRDLAEPLDNFLKNDGIAIYNSIPEESWNSIRINNNLYSLPMYIGIDLHKKGDIYYGIKRIYADKYGIDISTWGSDFWNHKDELDKIIQGEKENKSFSLFSPSLISYIVEYYPGYTPVVSVKSDIHPYVYDEKNKEIINIYESEPILKINTYFREFYNNNNDITYAYNDSENENVFTLINTNDSYYIKKAESYLQKDSIYDIAICKASEKKNEVYDFLNIIYTDKNIIQAIEDCFGTNGIVIGNGFYDKYSFNNSDINDIKNGYSELNKSDIYGFVFDPVNVSKEMSDIACYLYEKYRLSTIPSIKNINLDEDNKVLHQLGIDKVLDEMNRQINEFKNNINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY4</accession>
    <name>A0A386PHY4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676422.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00386"/>
    <dbReference type="EnsemblBacteria" id="AYE33779">
        <property type="protein sequence ID" value="AYE33779"/>
        <property type="gene ID" value="CP523_04460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="137" mass="15913" checksum="39AAD33B1744E8B0" modified="2018-12-05" version="1">MFNWEVNLPNIGWFSMSIKEYLILMIILFYLCIFIFIFIAFVIGRFIKNSYIAFVACCILNGVSLIIPSLSPGNSKIIIYSTFTPFNLVYNPICRFMNSGALTMFKYYEGITIIVWSVLMVGFMYYSIKTFKKECIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI16</accession>
    <name>A0A386PI16_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mreD</name>
        <name evidence="9" type="ORF">CP523_10595</name>
        <name evidence="10" type="ORF">EI377_05380</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674175.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01382"/>
    <dbReference type="EnsemblBacteria" id="AYE34814">
        <property type="protein sequence ID" value="AYE34814"/>
        <property type="gene ID" value="CP523_10595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60208">
        <property type="protein sequence ID" value="QAS60208"/>
        <property type="gene ID" value="EI377_05380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017225">
        <property type="entry name" value="Cell_shape_determin_MreD_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037497">
        <property type="entry name" value="MreD_Clostridium/Treponema_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18859" checksum="0824AD54A3D4A97F" modified="2018-12-05" version="1">MKRLILILVLIGLLVLDNSLMPFLSIKGAFPSLLFMFSISYSIIKGRDEAVFIGILSGLLQDVFFYNIFGINALANMILCFLAAIIGENIYKNRKLIPVFTGLIASLLKVLVVYIILFLSNKYLNVETALFSTLYNTFIMFLFYNIIFKFCYNEYSIKSWKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI69</accession>
    <name>A0A386PI69_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium:sodium exchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_10805</name>
        <name evidence="7" type="ORF">EI377_05590</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677600.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02495"/>
    <dbReference type="EnsemblBacteria" id="AYE34854">
        <property type="protein sequence ID" value="AYE34854"/>
        <property type="gene ID" value="CP523_10805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60248">
        <property type="protein sequence ID" value="QAS60248"/>
        <property type="gene ID" value="EI377_05590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="SSF141072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362775" evidence="4">
        <location>
            <begin position="28"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="5">
        <location>
            <begin position="623"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="925" mass="103512" checksum="BB58A086C822866E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB8</accession>
    <name>A0A386PIB8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Murein L,D-transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07895</name>
        <name evidence="5" type="ORF">EI377_02585</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00682"/>
    <dbReference type="EnsemblBacteria" id="AYE34352">
        <property type="protein sequence ID" value="AYE34352"/>
        <property type="gene ID" value="CP523_07895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59749">
        <property type="protein sequence ID" value="QAS59749"/>
        <property type="gene ID" value="EI377_02585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07895"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="408" mass="46882" checksum="F63B04A1C8375914" modified="2018-12-05" version="1">MKIKSNTRNKKKKNFSLFKLISLFLFFIVLGAFTNIYLSNNYYNKLNEFYYSFNKCDFNTAQSKLASQSLFIKFHKNKYNQDLNNYFTGVIKKVCNSVKSGEITDNQALAILTEIKKYDVLNSSLDKLIASFDSNYASNSNKEDISNITNESLKSGIEALNNKDFLKAMSYFNSISKDNKKDFNSAKEYIHKTKEIYKNELITKSDELIANKYYTKAIELLSSYDTNILGENNKDINDKIHFVKMVKDEYLANIANEDSEYTSNAILQSITIDNVNALNIESKTPYFIYVNLLQQKTYIYEGAINNWKLIKTFESSTGLPGKETPKGVFAITGRGEWFFSEEFMQGGKYWVQFMGDYLFHSIPFNQDQSKIVDSTLGTPASHGCIRLEVDASKWLYDNAPNDTKIIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC5</accession>
    <name>A0A386PIC5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_11055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677100.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00929"/>
    <dbReference type="EnsemblBacteria" id="AYE34904">
        <property type="protein sequence ID" value="AYE34904"/>
        <property type="gene ID" value="CP523_11055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34975">
        <property type="entry name" value="PTHR34975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00912">
        <property type="entry name" value="2A0309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="365" mass="41550" checksum="6A052788667B18B6" modified="2018-12-05" version="1">MNKLSSKHFILFIIGATLISLKTYPSLFISIGGRDTWLCALVASIIFILYVYYIMNICKNTDTYDIKLIFTSSLSKTLGKILLFIFSINLFLSALESAAIEANALHSTFFIESPVWYALIFFLLPSIFLLNKNVRTIVIFVLVGVGSLIINSILFILLTQGYKNMDYVLPVLGNGLNKNFFITIALIIGSLSSFAITIPFMKYMIKNEHIKIHSLYASCISTGLIVVSILGIITSFGPLRSANIFYPEFVLGQRIQIGGFLEFGELFFLYQTVVGFFIKYILSTYGILIIYNKLFSNRKLFTLVYTFLIFVFSTFLGGSNFMLFKLLKYNEITNLIIFFVIPVIIFTIYNIKFKHRIKANLKNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID3</accession>
    <name>A0A386PID3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11960</name>
        <name evidence="2" type="ORF">EI377_06780</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35863">
        <property type="protein sequence ID" value="AYE35863"/>
        <property type="gene ID" value="CP523_11960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62170">
        <property type="protein sequence ID" value="QAS62170"/>
        <property type="gene ID" value="EI377_06780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="85" mass="9686" checksum="E2223DC1E9D0A2C3" modified="2018-12-05" version="1">MTYNTPAVYNGFTFDNIRFEFKDEKIIKTAANNSEKLNDIFNTDDGATYIGEFGGGEIYFDDILIRKDGVFIIPELYCLNPENLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE2</accession>
    <name>A0A386PIE2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10790</name>
        <name evidence="3" type="ORF">EI377_05575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.1" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674088.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01344"/>
    <dbReference type="EnsemblBacteria" id="AYE34851">
        <property type="protein sequence ID" value="AYE34851"/>
        <property type="gene ID" value="CP523_10790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60245">
        <property type="protein sequence ID" value="QAS60245"/>
        <property type="gene ID" value="EI377_05575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102480">
        <property type="term" value="F:5-fluorocytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="153"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="420" mass="47526" checksum="3AE020FFCFC33A07" modified="2018-12-05" version="1">MKSIIFKNVKLKGKEELVDLFVENGVYKEIGSNISKKYKDIESYDIEGNLVVPPYVDPHIHLDYVYTARMPGANNGTGTLFEGIQRWSETKGNMTIEEVKERARIALKKEILYGTQYLRTHVDVTDPKLTCLKAIMELKEEVKDLVDIQIIAFPQEGMYSYKGGDKLVEEALKMGADVVGAIPHFEFTREMGEKSVKKSVELAMKYNKLIDLHCDETDDEQSRFVELLAAESYMNGIGELTTASHTCAMGSYNNAYAFKLFKLLKLSNMNFISCPTENIHLQGRYDTYPKRRGLTRVKELNDAGINVCFAQDSISDPWYPLGNGNLMNILDAGIHICHMMSFEEINNALDLITVNGAKTLHIQDKYGIEVGKDANFIVLNAKNEFDAILERVGVNCSVRKGEFLFKREPEVINTNITLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF4</accession>
    <name>A0A386PIF4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12310</name>
        <name evidence="3" type="ORF">EI377_07135</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03018"/>
    <dbReference type="EnsemblBacteria" id="AYE35137">
        <property type="protein sequence ID" value="AYE35137"/>
        <property type="gene ID" value="CP523_12310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60529">
        <property type="protein sequence ID" value="QAS60529"/>
        <property type="gene ID" value="EI377_07135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="354" mass="39126" checksum="49E6D1DEFD8BA2CD" modified="2018-12-05" version="1">MRLVRLVLINIRRQLKNPSMLGMTLIFPIVMLLIINSGGLSEGGNIGVIDKSNTKYSNEIIERLSEKYSIDKLEGSAEDNYNLLRENKLGVIYVIDSDLKESLDKGEVPKIKGYRTEATSGVIMAEDIITKYISNILKEEVSQGLSENSTIAVINDEEVPKKDNYKMTVLMICYFMMIGGSIITGEVIKLKQEKVLRRTIATGNSDITILGSIFVSSFIIQGILSTAAFIILTFLLKIPKENIPQGILIIFLGSLITTAIIVAVSRWIKNVTLASLATVIIGITTFGIGFFGAELDSFENIPTIITRISALSPFTWLLKIINTNEIIIPVLIILLMSIASLTAGSFRLREFVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG3</accession>
    <name>A0A386PIG3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35893">
        <property type="protein sequence ID" value="AYE35893"/>
        <property type="gene ID" value="CP523_15240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021451">
        <property type="entry name" value="DUF3102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11300">
        <property type="entry name" value="DUF3102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="369" mass="42691" checksum="985DD5A07AEFA3E7" modified="2018-12-05" version="1">MDNNSDPLVKLIGNHLLKQIDINKVAVEKILKEKECIKNFTKYVESNYKDIGIQDYIELATDYFGIDAVQENVINISSNGELSVKRTPGLIAAEINDIKFKTKKMVLYNSIEIGRKLVEAKELLPHGEWGNWLEKEVEYSKSTANNLMKIFKEYGAEQTTLLGDNTKIQAFGSLSYSQAVLLLGIPLERREDFIKDNNVENLSTRELEKIIRELKQEKEEIIKEKKRALEKVNDLEETNKAFEVAFNSGAEERNRLETKIEKLEEEINQLVNKQIDATAGSTDSKLQEEVYRLKKEKEEKEVQLQNLQNELYTGNLNLKIYFDQAESIFKTLLKELEKVHVSKDEFERYSSLMESYGESILNKLENNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH4</accession>
    <name>A0A386PIH4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09600</name>
        <name evidence="7" type="ORF">EI377_04375</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:47680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:71674"/>
            <dbReference type="ChEBI" id="CHEBI:138150"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. AgaS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676688.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02626"/>
    <dbReference type="EnsemblBacteria" id="AYE34658">
        <property type="protein sequence ID" value="AYE34658"/>
        <property type="gene ID" value="CP523_09600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60058">
        <property type="protein sequence ID" value="QAS60058"/>
        <property type="gene ID" value="EI377_04375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05010">
        <property type="entry name" value="SIS_AgaS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035464">
        <property type="entry name" value="SIS_AgaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="47"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="5">
        <location>
            <begin position="218"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="387" mass="43529" checksum="D65EA2E8CB8D0CB1" modified="2018-12-05" version="1">MFFGLTKERLQELGSTFTATEIRQQPKMWEETYKIVNENKEEIKKFLRNNLKSNTRVVLTGAGTSDYVGDTIYLYLAKKLNLRVEAIATTDLVSNPHEFVEEDTPTILVSYARSGNSPESVGAYDIFAKNIKDISQLVITCNKDGQLAKKAHGSEKNLCLLMPEESNDKSFAMTSSFSCMLLASLLVFDIENLEENKKYVDIVVSQGNSILDNKWEEIKDLVDLNCDRVVYLGSGALKGLCQEMALKNLELTSGKTVTVYESVLGFRHGPKSIINDNTLVIFMNSINEYTNLYDMDLIKEIHGDIGNHKLAVISYKSNDELNNLCDKYLNIDGKDVPEIYTVFNYMLFGQMFGLFSSLNLGISPDNPRPDGTVNRVVKGVIIHPYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM6</accession>
    <name>A0A386PIM6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12840</name>
        <name evidence="2" type="ORF">EI377_07710</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02805"/>
    <dbReference type="EnsemblBacteria" id="AYE35237">
        <property type="protein sequence ID" value="AYE35237"/>
        <property type="gene ID" value="CP523_12840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60631">
        <property type="protein sequence ID" value="QAS60631"/>
        <property type="gene ID" value="EI377_07710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="111" mass="12677" checksum="9F133D80772F9435" modified="2018-12-05" version="1">MNISLDLLKEIREIIGDDSMLRVQVLSRKAKEMLGDSDYLKNYVGGNLYIKVTVTKEGIKEIKMLKETEYKVTATDIFTVQDKLLEHYMTDLSVESSIENWKKVFGVGALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU1</accession>
    <name>A0A386PIU1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11800</name>
        <name evidence="3" type="ORF">EI377_06620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673409.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35041">
        <property type="protein sequence ID" value="AYE35041"/>
        <property type="gene ID" value="CP523_11800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60434">
        <property type="protein sequence ID" value="QAS60434"/>
        <property type="gene ID" value="EI377_06620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="127" mass="14571" checksum="DAC8175E74716261" modified="2018-12-05" version="1">MILRIDFDSETPIYLQIKNQIIQGIAKNEIEDGEELPSVRGLAEDIGVNMHTVNKAYNMLKEDGYIKVDRRKGAIVSLNLEETTGKFKGTLMSEIDYYMAECFNRGISKDDIKSMIDKVFINFKREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU6</accession>
    <name>A0A386PIU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09230</name>
        <name evidence="9" type="ORF">EI377_03975</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678326.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03052"/>
    <dbReference type="EnsemblBacteria" id="AYE34592">
        <property type="protein sequence ID" value="AYE34592"/>
        <property type="gene ID" value="CP523_09230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59992">
        <property type="protein sequence ID" value="QAS59992"/>
        <property type="gene ID" value="EI377_03975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="178" mass="19723" checksum="3C2736E6D9A75087" modified="2018-12-05" version="1">MQKIWEMFIAFFKIGAFTFGGGYAMIPLIEEEVVNRKKWLTKEEFVDILVVSQSFPGALAVNCSIFLGYKISGFIGALMALLAVVLPSFLIIIIIASFFMQFRNNYYVNAAFKGITAAVPMLVLIGAISLGKGLERNIRTLMTIIVALIALEVINVHPVIVILASALYGIIFLRKRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIV3</accession>
    <name>A0A386PIV3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15785</name>
        <name evidence="2" type="ORF">EI377_10490</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678927.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00116"/>
    <dbReference type="EnsemblBacteria" id="AYE35780">
        <property type="protein sequence ID" value="AYE35780"/>
        <property type="gene ID" value="CP523_15785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61116">
        <property type="protein sequence ID" value="QAS61116"/>
        <property type="gene ID" value="EI377_10490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="242" mass="28407" checksum="4FE42B4DE6B5CB0C" modified="2018-12-05" version="1">MGKVAAFFDIDGTIYREGLITEVFKKIIKYELVNENKWYRDVRPSYIKWDKRQGDYDTYLLKMVDIYTDAIKGINKYHIDYIAKRVIEQKGDRVYTFSRERIKWHKDQGHIVIAISGSPVELVREMSKKYKMDDYRGTIYKLGEDNTYNGDIIPMWDHESKLNAITELKDKYDIDLDKSFAYGDTSGDFTMFKSVGNPYAINPTKELIGKVKEDNALMDKIKLIVERKDVTYNLDINTIDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW0</accession>
    <name>A0A386PIW0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Primosomal protein N'</fullName>
            <ecNumber evidence="10">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">priA</name>
        <name evidence="13" type="ORF">CP523_00965</name>
        <name evidence="14" type="ORF">EI377_11460</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674653.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02326"/>
    <dbReference type="EnsemblBacteria" id="AYE35790">
        <property type="protein sequence ID" value="AYE35790"/>
        <property type="gene ID" value="CP523_00965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62209">
        <property type="protein sequence ID" value="QAS62209"/>
        <property type="gene ID" value="EI377_11460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="374"/>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB8</accession>
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
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            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    <sequence length="148" mass="17265" checksum="E5D03045360C5593" modified="2018-12-05" version="1">MENINKKSILFSIVMIFILVFMCFNWGKKNIEDITRRDLHCLVDTPYYVRGVYLDEQNLNVNISGNMDKEGCEEIVKKIYGKIKKNSIKGKNIVVNFASEENNLNRKVNDSHVEKMHTKVILNPKNLDIKVNLFENFNMTPEILKVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJD5</accession>
    <name>A0A386PJD5_CLOSE</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">DSM 7534</strain>
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    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE35028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673389.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35028">
        <property type="protein sequence ID" value="AYE35028"/>
        <property type="gene ID" value="CP523_11705"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60422"/>
        <property type="gene ID" value="EI377_06525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="211"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="303"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="529" mass="57394" checksum="B40B74324E05A4C3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJW5</accession>
    <name>A0A386PJW5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4397 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02915</name>
        <name evidence="3" type="ORF">EI377_13440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35807">
        <property type="protein sequence ID" value="AYE35807"/>
        <property type="gene ID" value="CP523_02915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62224">
        <property type="protein sequence ID" value="QAS62224"/>
        <property type="gene ID" value="EI377_13440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025510">
        <property type="entry name" value="DUF4397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14344">
        <property type="entry name" value="DUF4397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4397" evidence="1">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="204" mass="22530" checksum="BE7F744510D3CA46" modified="2018-12-05" version="1">MLFRDNLPDLQCKIRLIHAIPSAPAVDIYANGELIAKDLSFSDLSCYTTVAPGNYEVQLYVAGTYDTPLLTKNIDLLPNSASTISAITLNNNIDLFVLNDANTPGQINNSFLRFINLSSNSPLLTLSLPNDISLFNSVEYIETTGYYPLSPGIYNYKVSFGSSEGLFKFIKDLKLDNGKFYTIYIIGLFNNTPQLGYIIAQDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ8</accession>
    <name>A0A386PJZ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1887 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF1887 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07940</name>
        <name evidence="2" type="ORF">EI377_02700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675992.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35847">
        <property type="protein sequence ID" value="AYE35847"/>
        <property type="gene ID" value="CP523_07940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59764">
        <property type="protein sequence ID" value="QAS59764"/>
        <property type="gene ID" value="EI377_02700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015093">
        <property type="entry name" value="DUF1887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09002">
        <property type="entry name" value="DUF1887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="379" mass="43568" checksum="D5053658B42BE74D" modified="2018-12-05" version="1">MQVETLINQLDEHNEGNILATKKFKPELVIFIRTSKEEGKMKSIREYYNNYLPQVILKEKVIEEGDSSEIKNLINENKNGKVLVNLTGGKRINSLILLKICNENSIKSIYVDIKQKTLYTIDSNIEILKEDFGDLEIEDIIKASGGQVIQDSTKLCNEEDLVYLTKQIYKNLSIWHKHKQKLYDSNIFIHDWQDSKKVLIKTKFLDDNEKMLLDKILTKLKSMGGIIYKDIGSNEVEVSFLSDYLKAFIFKSGTWLEMATNMMIDEIKEVDQVKNGVIFLWNNDVKTVRNEVDVVAVKDSIPICVSCKDSDRYNEMALNELNVYSSKIGGEKAYKILVATKEPIKASVRERAKEMGINLVIFDGDENKFKKTIKAIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK41</accession>
    <name>A0A386PK41_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15050</name>
        <name evidence="3" type="ORF">EI377_10005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676023.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01274"/>
    <dbReference type="EnsemblBacteria" id="AYE35644">
        <property type="protein sequence ID" value="AYE35644"/>
        <property type="gene ID" value="CP523_15050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61031">
        <property type="protein sequence ID" value="QAS61031"/>
        <property type="gene ID" value="EI377_10005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="128" mass="13722" checksum="90E821E93FB5E41E" modified="2018-12-05" version="1">MESMNNDTNLGIVKISDEVVSVIAGIAASEIEGIVEGQQAVSNNISHLLKGKKAVGRNVKVTLGEDSAVIDLNVAVEYGIKIPEVVKAVQENVKKTVEAMTGLKVDSVNISVQSIYLPKKEKEECKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK55</accession>
    <name>A0A386PK55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14985</name>
        <name evidence="2" type="ORF">EI377_09940</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676048.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35631">
        <property type="protein sequence ID" value="AYE35631"/>
        <property type="gene ID" value="CP523_14985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61018">
        <property type="protein sequence ID" value="QAS61018"/>
        <property type="gene ID" value="EI377_09940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="26914" checksum="ADB17DB4462A3B1B" modified="2018-12-05" version="1">MKNILEIEDDIYTYKGNKYSKSNERDLLKDVGKNLKIIIIDEALLIKKFKVNTSERDIEEFINETIEKEFLVNENMLFHYEYVKSENIVYIYSIKQGNLVRKLGTKVNKLKVHPMQFIIKDFINKKIKKFRNFISITEFRGKYYVLNIHNNIIVKCYIWDKINNLNEVIESGIKNDNLIILDKNIELEKIDSYIKEKYVKYLNVGDIINEKLCRKQKFYTKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK98</accession>
    <name>A0A386PK98_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678785.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35691">
        <property type="protein sequence ID" value="AYE35691"/>
        <property type="gene ID" value="CP523_15325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="104" mass="11946" checksum="5BD0428A07EB2824" modified="2018-12-05" version="1">MKIKNKKTYYLRKKTIIEDNEGGKYPGYSESIEIQSNIGPASGKLQAEIYGERLNYILNMLYDGPKTINEGDGICVYVSKDSDPDYKVISIKRYSHLFIELEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKA8</accession>
    <name>A0A386PKA8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_12335</name>
        <name evidence="8" type="ORF">EI377_07225</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675367.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02045"/>
    <dbReference type="EnsemblBacteria" id="AYE35142">
        <property type="protein sequence ID" value="AYE35142"/>
        <property type="gene ID" value="CP523_12335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60547">
        <property type="protein sequence ID" value="QAS60547"/>
        <property type="gene ID" value="EI377_07225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="33942" checksum="CA2A0FBFADED259D" modified="2018-12-05" version="1">MHKVMVKGILSSNNGMNIYRGCTHGCIYCDSRSICYGMNHPFEDIEVKMNGSKLLEDILKKKRKKCMIRTGSMSDPYIHLEEKLQNTRRSLEIIEKYGFGLAIQTKSNRILRDLDLLRSINNKGKCVVQMTLTTYDEKLCRIIEPNVSTTKERFEVLKIMRNNGIPTVVWMSPILPYINDTEKNIRGILDYCIEAKVKGIIVFGIGLTLRDGNREYYYKNLDKHFKGLKEKYIRQYGNNYEVVSENHERLMKIIKETCKKNNIICGVEEVFRYMKTFEEKNNEIQLSFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKG6</accession>
    <name>A0A386PKG6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">murA</name>
        <name evidence="9" type="ORF">CP523_10215</name>
        <name evidence="10" type="ORF">EI377_05020</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674336.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01452"/>
    <dbReference type="EnsemblBacteria" id="AYE34749">
        <property type="protein sequence ID" value="AYE34749"/>
        <property type="gene ID" value="CP523_10215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60149">
        <property type="protein sequence ID" value="QAS60149"/>
        <property type="gene ID" value="EI377_05020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10215"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="419" mass="45394" checksum="9208EB891169633A" modified="2018-12-05" version="1">MEKIIVKGGKKLNGEVDISLAKNSVLPIMVASILSPNEVIIKNAPLLEDVSVLANLLEELNCDVDFSKITGDLKINTSNIEPMDTNNDLIRKMRASFLIMGPMLARFGKCKISLPGGCNIGSRPVDLHLKGFKMLGADIEIGHGFVEAEVKELKGNRIYLDFPSVGATENLLMASVLAKGTTIIENAAEEPEIWDLANFLNSMGAHIEGAGMGRITIEGVEALNGIEYKPLYDRIEAGTFMVAAAITNSIITINGVNEEHLRPTIEKLKECGVKFETKDDSIVVDGTGSKSPVDIKTLPYPGFPTDMQPQMMSLLSLTKGSSIVTETVFENRFMHVAELVRMGANIKIDGRTAIIDGVEALTGCDVKATDLRAGAAMILAGLAAHGDTKIGDLYHIDRGYTNIEEKFRKLGADVYRIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM7</accession>
    <name>A0A386PKM7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10625</name>
        <name evidence="4" type="ORF">EI377_05410</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674162.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34819">
        <property type="protein sequence ID" value="AYE34819"/>
        <property type="gene ID" value="CP523_10625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60214">
        <property type="protein sequence ID" value="QAS60214"/>
        <property type="gene ID" value="EI377_05410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="176" mass="20726" checksum="D5D5531BCC26516E" modified="2018-12-05" version="1">MGDYREEYRKYYEEVKRKANIKTNVENYKETPVDKTISIKEENIYPNSKAAYGSNYIGNYVVGYRGNYRGPGLSYNYGYSRREELQKPNRYVRRIIMRLTATALLFISVLVLKVLPYEQAKDIYSTCKEMVSENFNYVGFVEELKKFSSNAVKEVQGRIDEAKENQQNKIQNNEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKR9</accession>
    <name>A0A386PKR9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NERD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13610</name>
        <name evidence="3" type="ORF">EI377_08505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35874">
        <property type="protein sequence ID" value="AYE35874"/>
        <property type="gene ID" value="CP523_13610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62184">
        <property type="protein sequence ID" value="QAS62184"/>
        <property type="gene ID" value="EI377_08505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50965">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="45" mass="5539" checksum="6A7743F3F6FAFBCC" modified="2018-12-05" version="1">MFIRRKIVSQCIYTNRKWKKTEIDLILVNYYGIFVIESKNWTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKW1</accession>
    <name>A0A386PKW1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAC</name>
        <name evidence="2" type="ORF">CP523_15020</name>
        <name evidence="3" type="ORF">EI377_09975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676036.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01280"/>
    <dbReference type="EnsemblBacteria" id="AYE35638">
        <property type="protein sequence ID" value="AYE35638"/>
        <property type="gene ID" value="CP523_15020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61025">
        <property type="protein sequence ID" value="QAS61025"/>
        <property type="gene ID" value="EI377_09975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009570">
        <property type="entry name" value="Spore_III_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02848">
        <property type="entry name" value="spore_III_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="65" mass="6960" checksum="7BDDF33AF6E1645E" modified="2018-12-05" version="1">MLDVGIIFKIGAMGILLVVLDKVLKSSGKDDVAVITNIAGIVIILITLVGLIDNLFNTIKTMFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKZ7</accession>
    <name>A0A386PKZ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_13580</name>
        <name evidence="6" type="ORF">EI377_08475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679034.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35376">
        <property type="protein sequence ID" value="AYE35376"/>
        <property type="gene ID" value="CP523_13580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60766">
        <property type="protein sequence ID" value="QAS60766"/>
        <property type="gene ID" value="EI377_08475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="129"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="260" mass="30415" checksum="B165529B4CD52D2F" modified="2018-12-05" version="1">MYTVLHIEQSEFFLKIVESEVLEKGYEYISTENFNEANSILRENHIDLIITSLYAKGGKIEEFVKDVNSKYNIPIFVVTSNDIDEHSRKIINLGISEYILKKDMKEEIRKHLDNIFREDEYMECLKEVSIAVLEDNKLERIIEKKLLEDYGIKNVDYYMSGELLLNSNKKYDIYLIDIILKNEFGKDIIRKIRRNNIDASIIAVTGLDNEKTLANLLNTGANDFITKPVNEDMFIAKLKSNVRVYNLEKKLKELKKTNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL17</accession>
    <name>A0A386PL17_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">CP523_14375</name>
        <name evidence="10" type="ORF">EI377_09340</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676799.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02465"/>
    <dbReference type="EnsemblBacteria" id="AYE35522">
        <property type="protein sequence ID" value="AYE35522"/>
        <property type="gene ID" value="CP523_14375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60908">
        <property type="protein sequence ID" value="QAS60908"/>
        <property type="gene ID" value="EI377_09340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="135"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="199"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="447" mass="49801" checksum="652244DF3FB46A02" modified="2018-12-05" version="1">MKLEMNKNELRRFLLHAPQDKVMKYIEGAHPVDILDVLRENIDERKDILNRLSEKFIASIIDEADAEEKYHILMEFSENKQKNIVEEMSSDELTDLLGILDESQANKILAKMTAEDARMVRQLLSYDPDTAAGIMATEFISVKDNMTVRETLKYLQETSKEAENIYDLYVIDSLDKLKGVVSLRDIVTSNFDTLISDIVQENLVSIPYDMDQEEVGHIFEKYGYLTIPVVDTFNRLLGIVTVDDVMQILRDENTEDIHRLGGVAEGEKINGTLSESVKSRLPWLFINLLTAILASSIVGIFEGTIEKVVSLATFMPIVAGMGGNAGTQTLTIIVRGLALGELNYKNVKRVLFKEIGIGVITGLVIGLLIAILGYIWEGKVIFGVVIGIAMLLNMIIATISGFLVPVILKKLKVDPALASSVFVTTFTDVLGFFFFLGLATVFIGYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLB1</accession>
    <name>A0A386PLB1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ORF">CP523_07110</name>
        <name evidence="6" type="ORF">EI377_01855</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673875.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01037"/>
    <dbReference type="EnsemblBacteria" id="AYE35838">
        <property type="protein sequence ID" value="AYE35838"/>
        <property type="gene ID" value="CP523_07110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62148">
        <property type="protein sequence ID" value="QAS62148"/>
        <property type="gene ID" value="EI377_01855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="144" mass="16227" checksum="6B5FCA5EED294476" modified="2018-12-05" version="1">MEVAIEEAKKAYIKGEVPIGAVIVKDGNIISKAHNLKEALKRPTAHAEIMAIEEACVKLDNWRLNGCEMYVTLEPCPMCAAAIAQSRISKLYIGTFNKDMGACGSTINLLDYDIFNFYVDVKWCYNEECSKILTEFFYSRRNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLX5</accession>
    <name>A0A386PLX5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="6" type="ORF">CP523_06710</name>
        <name evidence="7" type="ORF">EI377_01175</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00029"/>
    <dbReference type="EnsemblBacteria" id="AYE35836">
        <property type="protein sequence ID" value="AYE35836"/>
        <property type="gene ID" value="CP523_06710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59546">
        <property type="protein sequence ID" value="QAS59546"/>
        <property type="gene ID" value="EI377_01175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="7"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="691" mass="76843" checksum="0DA5C98D3A77A5C7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLX8</accession>
    <name>A0A386PLX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14595</name>
        <name evidence="3" type="ORF">EI377_09565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678668.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00193"/>
    <dbReference type="EnsemblBacteria" id="AYE35559">
        <property type="protein sequence ID" value="AYE35559"/>
        <property type="gene ID" value="CP523_14595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60946">
        <property type="protein sequence ID" value="QAS60946"/>
        <property type="gene ID" value="EI377_09565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="260" mass="29261" checksum="168AB19DBFABE822" modified="2018-12-05" version="1">MIYIESKDNALFKATKKLKEKKNRNKEGKYIIEGFRLIEEAFKANMQVEYIILSEESQNKLNEYLSEYIDKNSKIYVLSGNLISQLTSTEHPQGVVAVVKNREMPKEINGDFYLLCDKVQDPGNLGTIIRTAHAAGVDGIILTKGTVDIYNDKTIRSTMGSIFYVPIIYEDENLNFLNKLRNEGFSLVSTSLEESKDFFKEDLRGKVILSVGNEGNGISEEIFSLSDKKVKIPMPGGAESLNVAVATSIILFEKVRQNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLZ5</accession>
    <name>A0A386PLZ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_12560</name>
        <name evidence="8" type="ORF">EI377_07450</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675381.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02001"/>
    <dbReference type="EnsemblBacteria" id="AYE35866">
        <property type="protein sequence ID" value="AYE35866"/>
        <property type="gene ID" value="CP523_12560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62174">
        <property type="protein sequence ID" value="QAS62174"/>
        <property type="gene ID" value="EI377_07450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="MUTSd" evidence="5">
        <location>
            <begin position="44"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="6">
        <location>
            <begin position="325"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="517" mass="59702" checksum="49A0284512923A66" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMB0</accession>
    <name>A0A386PMB0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_03360</name>
        <name evidence="5" type="ORF">EI377_13875</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02111"/>
    <dbReference type="EnsemblBacteria" id="AYE35809">
        <property type="protein sequence ID" value="AYE35809"/>
        <property type="gene ID" value="CP523_03360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62227">
        <property type="protein sequence ID" value="QAS62227"/>
        <property type="gene ID" value="EI377_13875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033866248" description="Peptidyl-prolyl cis-trans isomerase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="200" mass="21631" checksum="E418B8BE83D25655" modified="2018-12-05" version="1">MLATSLSLVVLVGCTSSKNNGKKEGSTENLPIATIKIKDYGNIEAELYPDIAPNTVNNFISLANDGFYNNLTFHRIIEGFMIQGGDPEGTGVGGPGYSIKGEFKSNGFENNLKHEKGVLSMARTNDPNSAGSQFFIMTEDASHLDGQYAAFGKVISGIDVLEKVEKVETDSNDKPKTDVIIESITVDTKGEKYNKPEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBS3</accession>
    <name>A0A386PBS3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rubrerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02410</name>
        <name evidence="7" type="ORF">EI377_12930</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673970.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33393">
        <property type="protein sequence ID" value="AYE33393"/>
        <property type="gene ID" value="CP523_02410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61565">
        <property type="protein sequence ID" value="QAS61565"/>
        <property type="gene ID" value="EI377_12930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="22330" checksum="94AC7FCD3954E7BD" modified="2018-12-05" version="1">MELKDSKTKENLMRAFAGESQARNRYNIAAGIAKKEGLNIIEKAFNYTADQERAHAKVYYEALNEFSGQNIGVGPAEYPVDVYNNTLQALKAAQHNEYEEWDKVYKEFGEIAKEEGFTLIASHFNKIATIEKIHGDRFGRFAIELENGSLFKKEEEVQWMCTNCGFIYEGKEAPKVCPVCSHPQGYFLIFATSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC03</accession>
    <name>A0A386PC03_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxynucleoside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_01835</name>
        <name evidence="7" type="ORF">EI377_12355</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCK/DGK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02384"/>
    <dbReference type="EnsemblBacteria" id="AYE33290">
        <property type="protein sequence ID" value="AYE33290"/>
        <property type="gene ID" value="CP523_01835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61461">
        <property type="protein sequence ID" value="QAS61461"/>
        <property type="gene ID" value="EI377_12355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002624">
        <property type="entry name" value="DCK/DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000705">
        <property type="entry name" value="DNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="dNK" evidence="5">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="145"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000705-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="217" mass="25703" checksum="0DEE6853232EC8BF" modified="2018-12-05" version="1">MLIVVGGMIGLGKSSVASILGEHFNTDVFYESVDDNPILPLFYSETEEEIQKKRYPFLLQLYFLNTRFKSIKDALVHNNNVLDRSIYEDWYFAKKNMELGRINDLEMKIYEDLLNNMLEEIEELPKKAPDLMVYLKGSFETVLKRIALRGRDFEIDDSLREYYEFLWKDYDAWVNNHYKASQVLIIDMDIMDVVNNEDDKVKLINMVEEKLKEVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC55</accession>
    <name>A0A386PC55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA metabolism protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03150</name>
        <name evidence="3" type="ORF">EI377_13665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677274.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02154"/>
    <dbReference type="EnsemblBacteria" id="AYE33533">
        <property type="protein sequence ID" value="AYE33533"/>
        <property type="gene ID" value="CP523_03150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61696">
        <property type="protein sequence ID" value="QAS61696"/>
        <property type="gene ID" value="EI377_13665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023875">
        <property type="entry name" value="DNA_metab_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025404">
        <property type="entry name" value="DUF4130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13566">
        <property type="entry name" value="DUF4130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03915">
        <property type="entry name" value="SAM_7_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4130" evidence="1">
        <location>
            <begin position="84"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="245" mass="29458" checksum="0F0FB8AB3257FFBE" modified="2018-12-05" version="1">MITYIYDGSFQGLLSAIYDSFYSKIPPNSILAKNEYSIDLLSTYININTDYKKYKKVKESIILKIDRLCLEKIYKLYLSSEKDKGILCFKYLKLAFKVSNKIHSFLHLDIVRNINLIDRRVSLEAHRFTGLVRFSYIGNKFLYSQIYPDNNILELISPHFEKRLPNEYWIIHDTKRNIATIYNKISWEITELDKNDYMNLSKSFDNFEELWKEYFKSTTIDERLNLKLQKRSMPKRYWKNLTELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCE2</accession>
    <name>A0A386PCE2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 10" type="primary">ftsZ</name>
        <name evidence="9" type="ORF">CP523_01090</name>
        <name evidence="10" type="ORF">EI377_11585</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674451.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02300"/>
    <dbReference type="EnsemblBacteria" id="AYE33147">
        <property type="protein sequence ID" value="AYE33147"/>
        <property type="gene ID" value="CP523_01090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61317">
        <property type="protein sequence ID" value="QAS61317"/>
        <property type="gene ID" value="EI377_11585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="207"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="374" mass="39876" checksum="781308BE3612DFE8" modified="2018-12-05" version="1">MLDFEVDMQELTNIKVIGCGGGGGNAVNRMIAEGLKNVEFIAVNTDKQALMLSHANVKIQIGDKLTKGLGAGANPEIGKKAAEESREEIAEAIKGANMVFITAGMGGGTGTGAAPVVAEIAKAMNILTVGVVTKPFPFEGKRRMRHAEMGIENLMNAVDTLVIIPNERLLSMADKKTTLLDSFKLADDVLRQGVQAISDLITIPGVVNADFADIETVMLNKGLAHMGVGHGTGDNKAQDAVRQAISSPLLETSIDGATGVIINFTGGVDLGAIEVYEAADIVRESADPDANIIFGAVIDETLTDEIRITVIATGFEEENSKLSMEKPVIEKKTVVRQQVQRPEDISMDQPKRVDPLLDIDTDSVNIPSFLRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCH9</accession>
    <name>A0A386PCH9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secG</name>
        <name evidence="11" type="ORF">CP523_03855</name>
        <name evidence="12" type="ORF">EI377_14390</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675499.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01543"/>
    <dbReference type="EnsemblBacteria" id="AYE33663">
        <property type="protein sequence ID" value="AYE33663"/>
        <property type="gene ID" value="CP523_03855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61825">
        <property type="protein sequence ID" value="QAS61825"/>
        <property type="gene ID" value="EI377_14390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788371" description="Protein-export membrane protein SecG" evidence="10">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="8178" checksum="B17376FB88F9A546" modified="2018-12-05" version="1">MKNFLFILEAVLGLLIIVSVLLQPSKADALSGLIQGSKTETFFSKNKARTKEAMLVKLTIISAAAFAINTIALNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCN4</accession>
    <name>A0A386PCN4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0229 protein CP523_04120</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0229 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676883.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02761"/>
    <dbReference type="EnsemblBacteria" id="AYE33715">
        <property type="protein sequence ID" value="AYE33715"/>
        <property type="gene ID" value="CP523_04120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01232">
        <property type="entry name" value="UPF0229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014230">
        <property type="entry name" value="Spore_YhbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006698">
        <property type="entry name" value="UPF0229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30510">
        <property type="entry name" value="PTHR30510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04285">
        <property type="entry name" value="DUF444"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02877">
        <property type="entry name" value="spore_yhbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="390" mass="45080" checksum="8BF289D6F5573206" modified="2018-12-05" version="1">MAIFRDASDNPLEHDRSVEDRRRHRQLVEKSIKENLGDILSEESIIGESKNKKFRIPIRGIKEYQFVFGRNNKGVATGTGEEKRGDKIGDGSPSGKNGNQGAGNARGDDIYDTEITLEELMDYIIEDLDLPNLDRKKYSDIITESSGRKRGYQRYGINPRLAKKKTVMSKIARKQGKKRALMEAGIDTEIERFPFREDDLRYYKVKKKPKKESNAVMIFIMDVSGSMDSTKKYLARSFFFVLSRFIKRKYNNIAFEFVSHTTVAKQVNEYEFFHKAESGGTYISSGLNVALDLIKEKYPPEMWNIYPIYASDGDNWSEDNERAIIAVKELCQVSNMFGYAELLPSTYSTTMYYRFEKDINCKNFQAVIVKEKKDLWEALKVMLCKELKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCS4</accession>
    <name>A0A386PCS4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ORF">CP523_00960</name>
        <name evidence="4" type="ORF">EI377_11455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674525.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02327"/>
    <dbReference type="EnsemblBacteria" id="AYE33124">
        <property type="protein sequence ID" value="AYE33124"/>
        <property type="gene ID" value="CP523_00960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61294">
        <property type="protein sequence ID" value="QAS61294"/>
        <property type="gene ID" value="EI377_11455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="16453" checksum="E9542604BEFAE36C" modified="2018-12-05" version="1">MGIRNIRKNGDEVLRKKCKPVEKITNRTLQILDDMVDTMYEADGVGLAAPQIGILQKMFVIDVYDGEGVRVFINPEILEMSGSQTGEEGCLSIPGELGEVERANYVKVKALNEKGEEFTLEATELLARAIQHENDHLYGKLFIDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCS9</accession>
    <name>A0A386PCS9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04440</name>
        <name evidence="3" type="ORF">EI377_14985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676428.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33775">
        <property type="protein sequence ID" value="AYE33775"/>
        <property type="gene ID" value="CP523_04440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61933">
        <property type="protein sequence ID" value="QAS61933"/>
        <property type="gene ID" value="EI377_14985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="152" mass="17263" checksum="C00F221C0F436701" modified="2018-12-05" version="1">MELVKRDKKNITTRMALLLGFIPMVNNINIVVVSAILAIILIKTNIINNGVKKRFNIGEVFIYNLKCMILYYLVAFTITLFTYSEVLNIFQIRNNNGLLDYAFMLLDPKIILISISITLSSYICSLKHSKSGILSIILAIINTALLIYIIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCX5</accession>
    <name>A0A386PCX5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04770</name>
        <name evidence="4" type="ORF">EI377_15280</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01718"/>
    <dbReference type="EnsemblBacteria" id="AYE33833">
        <property type="protein sequence ID" value="AYE33833"/>
        <property type="gene ID" value="CP523_04770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61979">
        <property type="protein sequence ID" value="QAS61979"/>
        <property type="gene ID" value="EI377_15280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="358" mass="41854" checksum="928E23E963614CF5" modified="2018-12-05" version="1">MIKENTIKEINYIKGIAILLVFIGHASTPSFLQRPYTYEFMVQLIYSIHMPLFFLVSGFLSYKIINMNLNKEYLSFIKTKFYRLGVPFLIFSFITNFIIIAFKQVLNEPVSTSTLLDRIKTIFLYPEDGIMGALWFLYTLFFIAILAPFIVKLPLKLTITLSLLLNIFTPKYINFLSISRINFFLVYFLIGLYFRTYYQANKNNIFKMISTFKKITLFIISAICIFSYSYIITNGIFISKYLLSTLNFLCGLCGMILILMLIEKIKNLKVCSTLSYLGQYSMDIYLFSWFFQITSMILITKILKISNYNIFFISNMIVGSFCLPFSIYILRRFKIFKRLLLGEFQNNVSLKSTPSITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD09</accession>
    <name>A0A386PD09_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03945</name>
        <name evidence="4" type="ORF">EI377_14470</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675526.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01559"/>
    <dbReference type="EnsemblBacteria" id="AYE33680">
        <property type="protein sequence ID" value="AYE33680"/>
        <property type="gene ID" value="CP523_03945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61837">
        <property type="protein sequence ID" value="QAS61837"/>
        <property type="gene ID" value="EI377_14470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="173"/>
        </location>
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        <location>
            <position position="113"/>
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        <ligand>
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            <position position="173"/>
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        <ligand>
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        <ligand>
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        <ligand>
            <name>substrate</name>
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        <location>
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        <ligand>
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            <position position="249"/>
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        <ligand>
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            <position position="363"/>
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        <ligand>
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        <location>
            <position position="366"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-1"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="396" mass="45945" checksum="B899E9BDA888BB7E" modified="2018-12-05" version="1">MIKEINVEEIKKREEFLNTKLLSKEEVKTAIENAIKQIDANMDYFKDKFPSSATKENKYGIIENIEWTDGFWTGMLWLAYEYTGDEKYRVLAEKNVASFKNRVDKDIEIDHHDLGFLYSLSCVSGYKLTGSEMAKEASVKAADKLISRYQEKGEFIQAWGELGSKDHYRFIIDCLLNIPLLYWASDVTGDNKYRELADKHFVTSCNNVIRDDASAFHTFYMDPETGKPVKGITRQGYSDDSAWARGQAWGVYGIPLNYKNTKNEACFNLYKGMTNYFLNRLPKDNVCYWDLIFNDGDGHSKDSSAAAIAVCGMHEMNKFIPEVDEEKEVYKYAMHNILRALIKDYTHKDVQEGKPILLHGVYSWHSGKGVDEGNIWGDYFYLEALIRFYKDWELYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD22</accession>
    <name>A0A386PD22_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02305</name>
        <name evidence="4" type="ORF">EI377_12825</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33377">
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        <property type="gene ID" value="CP523_02305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61547">
        <property type="protein sequence ID" value="QAS61547"/>
        <property type="gene ID" value="EI377_12825"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="187" mass="21528" checksum="F87D6D6FC9F9706C" modified="2018-12-05" version="1">MSLKKFILGAIIFTIIIVLGFTSVNIETTKALSPTGDGADNYAMVSKEFGKDFEEFIRDNAMVKIYVPKDDDDNTTIKVYNNEFRVKKENPFVKGFYEVVYKFSNSFNSIKNKIDGKLKKNNENTNNQLDNIVDDFIKEREEEKSQNKNIKKEEKNINKEENEGSNINIDEKKNTEGENINKKSSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDB6</accession>
    <name>A0A386PDB6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04530</name>
        <name evidence="6" type="ORF">EI377_15090</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676404.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00371"/>
    <dbReference type="EnsemblBacteria" id="AYE33790">
        <property type="protein sequence ID" value="AYE33790"/>
        <property type="gene ID" value="CP523_04530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61948">
        <property type="protein sequence ID" value="QAS61948"/>
        <property type="gene ID" value="EI377_15090"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="227" mass="26054" checksum="FF86B3A9BB22B6EE" modified="2018-12-05" version="1">MIIKLNKINKFYGYRGNKIKALNSIDLEIEKGKFISIMGPSGCGKSTLLNILGCIDSPDNGEYYLKRNKIDFKKINSLSEIRNRDIAMIFQNFALIRDLSVMENCLLPLKFRKEKSKYKKEVVEKYLKELGLYELRKKRVVELSGGQQQRVAIVRALAQETDIILADEPTGALDEQNTKSIMELLKKLNKEFNKTIIVVTHDKLVASYSDKTLFMKDGKILKLNIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDG1</accession>
    <name>A0A386PDG1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase MtaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mtaB</name>
        <name evidence="12" type="ORF">CP523_02240</name>
        <name evidence="13" type="ORF">EI377_12760</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE33364">
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        <property type="gene ID" value="CP523_02240"/>
    </dbReference>
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        <property type="gene ID" value="EI377_12760"/>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
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        <property type="entry name" value="Methylthiotransferase"/>
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        <property type="entry name" value="rSAM_horseshoe"/>
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        <property type="entry name" value="ThrcA_tRNA_MEthiotransferase"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="threonylcarbamoyladenosine_tRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
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            <begin position="1"/>
            <end position="113"/>
        </location>
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            <end position="368"/>
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            <end position="434"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AYE33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61534.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="434" mass="49265" checksum="E0543E33B1455E1B" modified="2018-12-05" version="1">MKVAFATLGCRVNVYESEAMAEKFIREGYEVVDFSEVADVYVINTCTVTNMGDKKSRQIIGRARRLNENAIIAVVGCYSQMAPKEVSEIPGVDVVLGTRNKGDVVYYVNKAKDEGKNQVHVEGVLKNKKFEDLNIEDYQDKTRAFLKIQDGCNRFCTYCLIPYARGSVCSKDPKKVISEVKKLAEHGFKEIILSGIHTASYGLDLEGNVTLINIIEEIEKVEGIERIRIGSIEPAFFTPEVIEKIKKFKKLCPHFHLSLQSGCDATLKRMNRRYTSKEYEDTVKLLRETLKGVSITTDVIVGFPGETEEEFNETLEFLKRIKLTKTHVFKYSPRKGTKAADMENQIDGNIKEKRSKILIDLSNKNEEEFNKKFINSKMDVLIEKEVKEKEGIFEGYTRNYIKIEVPCTCSDITGKIVDIKIIEANGELAKAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDI2</accession>
    <name>A0A386PDI2_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">NAD(P)H nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03170</name>
        <name evidence="3" type="ORF">EI377_13685</name>
    </gene>
    <organism evidence="2 4">
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        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
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            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AYE33537">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="181" mass="20870" checksum="24EE89F9DF9DC84F" modified="2018-12-05" version="1">MSFFNLIYKRESVRGYFDKVVEREKIEKIIDAARVAPSACNSQPWKFVVVDSEKLTKDLAKTLYDPLIGINKFTTTSRAFIVVVGERRNLTSKFGELVKKKDYTSIDIGIACEHICLAATELGLGTCMIGWFKEKEIKNILDIPKNKEIYLVISVGYFENKEPRKKVRKNIEEVISYNKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDI3</accession>
    <name>A0A386PDI3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoVAC</name>
        <name evidence="2" type="ORF">CP523_02350</name>
        <name evidence="3" type="ORF">EI377_12870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673989.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00497"/>
    <dbReference type="EnsemblBacteria" id="AYE33384">
        <property type="protein sequence ID" value="AYE33384"/>
        <property type="gene ID" value="CP523_02350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61555">
        <property type="protein sequence ID" value="QAS61555"/>
        <property type="gene ID" value="EI377_12870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014203">
        <property type="entry name" value="Spore_V_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02838">
        <property type="entry name" value="spore_V_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="156" mass="16835" checksum="76722A4A7F853849" modified="2018-12-05" version="1">MAKKHSAKEQQIVNRFKTITKEAEPKPKIVKNCARAFLVGGAICTIGQIFQFLLLKYGFPEEEVKTLLPIILVFLGALLTGVGIYDKIANFGGAGTVVPITGFANAIVAPAIEFKKEGFVFGVAAKMFTIAGPVLVYGIGSSVIIGIIYYFIKVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDJ9</accession>
    <name>A0A386PDJ9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0735 ACT domain-containing protein CP523_02470</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02470</name>
        <name evidence="4" type="ORF">EI377_13005</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0735 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673954.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00473"/>
    <dbReference type="EnsemblBacteria" id="AYE33404">
        <property type="protein sequence ID" value="AYE33404"/>
        <property type="gene ID" value="CP523_02470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61578">
        <property type="protein sequence ID" value="QAS61578"/>
        <property type="gene ID" value="EI377_13005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00707">
        <property type="entry name" value="UPF0735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008310">
        <property type="entry name" value="UPF0735_ACT_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025624">
        <property type="entry name" value="ACT_PheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="145" mass="16672" checksum="A11986D772FAC454" modified="2018-12-05" version="1">MKGNYLVIDKRVLPEVFEKVVKAKRLIEERKVKDVTEATKTVEISRSVYYKYKDFVFEFSQTDIGKKVTLNLIIEDRKGALSCILNYISNEGGSIITINQGVPMNKMANLSITVDISNLRCDLKNWLNEIEKLEYVGKVEFIAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDM4</accession>
    <name>A0A386PDM4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00030</name>
        <name evidence="2" type="ORF">EI377_10515</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32948">
        <property type="protein sequence ID" value="AYE32948"/>
        <property type="gene ID" value="CP523_00030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61121">
        <property type="protein sequence ID" value="QAS61121"/>
        <property type="gene ID" value="EI377_10515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="434" mass="51859" checksum="859A4E0ABE172989" modified="2018-12-05" version="1">MKNSTIIDNVANQTNLPKWWVESIAIQYFNPREITLEKEDNLWKLDYSKLDEDELAEAAIYKKSVISNYKIFHNIKEKVFYKRYIGDKRNIENRDLLLKEYDEIIANGLVSKYYVAFKEKEGYIESPENILNSYYQVLDNENIYQWKVLDSIRYCEETFNFNYVNEIFSLQEKHDYLVNLLIRSEEVDEKEIRDKTEEYLEWCNVVKRSLAKTLYDAHLARLSRIDENNEHNINKVIKEEPPLISSYENFTLKDGIFKSNHNFSGFFYKKSLEHLKKAKYIEEVSKSDKELLKNIDNLYNEKLLSLIMGLKCVETYINSIGNSYFKDIWDETINFTLKSKIRFYLKLTSRKVDLDEEYKDITNSIYNLVNLYDEFINSNMEFKESYIENNIIITTLGVKLSDRDLNNIDIILNEFIVYLSKKCNIKLPCWIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDN4</accession>
    <name>A0A386PDN4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="8" type="ORF">CP523_00080</name>
        <name evidence="9" type="ORF">EI377_10560</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00297"/>
    <dbReference type="EnsemblBacteria" id="AYE32958">
        <property type="protein sequence ID" value="AYE32958"/>
        <property type="gene ID" value="CP523_00080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61130">
        <property type="protein sequence ID" value="QAS61130"/>
        <property type="gene ID" value="EI377_10560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00080"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="301"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="430"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="478"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="563"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="635" mass="71500" checksum="242E68BF3212298B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDP7</accession>
    <name>A0A386PDP7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02730</name>
        <name evidence="3" type="ORF">EI377_13255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676959.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00952"/>
    <dbReference type="EnsemblBacteria" id="AYE33454">
        <property type="protein sequence ID" value="AYE33454"/>
        <property type="gene ID" value="CP523_02730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61625">
        <property type="protein sequence ID" value="QAS61625"/>
        <property type="gene ID" value="EI377_13255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="14982" checksum="75847305E6242B3F" modified="2018-12-05" version="1">MQFVVFKLGKEHFAVETEKIQSINDMMSITKVPKAPIYIKGLINLRGSIKSLVDINLLLNIASDRQQSNIIILKLDEEEIGIAVDEVDEVIDIDDNNLQKLELHSNQGYLRGVIEINDKLLTIIDIEKLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDQ5</accession>
    <name>A0A386PDQ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YitT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_06490</name>
        <name evidence="10" type="ORF">EI377_00970</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677445.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34145">
        <property type="protein sequence ID" value="AYE34145"/>
        <property type="gene ID" value="CP523_06490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59513">
        <property type="protein sequence ID" value="QAS59513"/>
        <property type="gene ID" value="EI377_00970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="278" mass="30256" checksum="6538829007ECBD2B" modified="2018-12-05" version="1">MEKVKEYLLSTLGVGIVAFSLEYFFFPNGVAAGGISGLALALNFIIKIEPSILTFIFNIILFAMAFFLIDRSFGTKSIYATVMLSVFMWLAERFLHPVAITDNLILSSIFGSACIAMGTAIVFHQGASTGGTSIIAKIINKYLGVPIGQGLLLSDCTVTLLAIYVFGIEKGLFGLLSAILIGNLVDKFIDGFNPVKQVFVVTRKEKLVVDFITNEIDRGCTILTGKGGYTKVDTTIIYTVLTTKQFITLKKFIKENNPEAFVTVNESTEALGKGFADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDT0</accession>
    <name>A0A386PDT0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA</name>
        <name evidence="12" type="ORF">CP523_01215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674372.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02275"/>
    <dbReference type="EnsemblBacteria" id="AYE33171">
        <property type="protein sequence ID" value="AYE33171"/>
        <property type="gene ID" value="CP523_01215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01215"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="271" mass="30386" checksum="9231A36A8C4057CD" modified="2018-12-05" version="1">MSRELIRSISVWDKVNVARHKDRPNGKFYIDNIFENFIELHGDRNFGDDKAIIGGIASINNESVTVIAINKGENTKENLERNFGMPNPEGYRKALRLMKQAEKFKRPVICFIDTPGAFCGVGAEERGQGQAIAQNLMEMSRLKTPIISIVIGEGGSGGALALAVADKVLMLEHSIYSILSPEGFASILWKDGSKAKEAAEVMKITAQDLKEFKVIDKVIREPRGGAHKHKIRMALGIKKELLEYIKELKEKEIEALLNERYQKFRNIGNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDW0</accession>
    <name>A0A386PDW0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_06920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673639.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00997"/>
    <dbReference type="EnsemblBacteria" id="AYE34205">
        <property type="protein sequence ID" value="AYE34205"/>
        <property type="gene ID" value="CP523_06920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="19"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="479" mass="51494" checksum="280B869579638FC0" modified="2018-12-05" version="1">MDSVNSCNVELKKGLKSRHLSMIAIGGSIGTGIFLAMGDTIHKAGAGGALVAYALIGIMVYFLISSLGEMATFMPVSGSFGTYATEFIDPAVGFALGWNYWFNWAITIAAELVASSLIMKFWFPNVPGIIWSVLLLSIIVTLNLLSTKAYGESEFWFASIKVITVIVFLIIGFLNIFGIMGGHAVGFSNFTSNGGPFIGGFKSIFIVFLLAGFSFQGTELVGIAAGESENPEKSIPKAVNSVFWRILLFYIGTIVVIGALIPLSEVGVKESAFTLVFEKAGVAAAASIMNAVILSSVLSAGNSGMYASSRMLYSMAKEGMAPKLFAKVNSNGVPINSVIATTIIASACFLTGIYAEDSVYVWLVAASGLAGFIAWMGIALCHYRFRKACKAQNFDLNKLPYKSKFFPFGPIIALILCTIVILGQGLSYISESGIDWMGICSSYIGIPLFLILWLGYKFKNKTKLVDLKKVNLTKYSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDZ9</accession>
    <name>A0A386PDZ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-hydroxy-acid oxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_05835</name>
        <name evidence="5" type="ORF">EI377_00320</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675003.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01870"/>
    <dbReference type="EnsemblBacteria" id="AYE34020">
        <property type="protein sequence ID" value="AYE34020"/>
        <property type="gene ID" value="CP523_05835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59392">
        <property type="protein sequence ID" value="QAS59392"/>
        <property type="gene ID" value="EI377_00320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="466" mass="51614" checksum="03617947195862C4" modified="2018-12-05" version="1">MSYKKVDKHDIEYINSIINDSERVLVGEDISEDYSHDELGAIKQMPEIVVQVLETEEVSRIMKYAYEKNIPVTPRGSGTGLVGSAVPLHGGIIIDLSKMNKILELDEENLTLTLEPGVLLMEIAKYVEEHDLFYPPDPGEKTATIGGNISTNAGGMRAVKYGVTRDYVRGLEVVLPNGDVVNFGGKVVKNSSGYSLKDLMVGAEGTLGIVTKAILKLLPLPKKAISLLVPFKDLDTAIETVPKIIKSKAIPTAIEFMERDAIVSAEEFLGKKFPDNSSDAYLLLTFDGNSKEDVEKDYEKVADICLKEGALDVFISDTDERQESIWSARGAFLEAIKASTTEMDEVDVVVPRNKVAEFVKFTKEVEKQFSIRIRSFGHAGDGNLHVYILKDNLKEKEWHDKLNDVMEAMYHRSKELNGKVSGEHGIGFAKKGYLHEAIGDEMINIMDGIKKAFDPKNLLNPGKVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA4</accession>
    <name>A0A386PEA4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03435</name>
        <name evidence="3" type="ORF">EI377_13960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02238"/>
    <dbReference type="EnsemblBacteria" id="AYE33584">
        <property type="protein sequence ID" value="AYE33584"/>
        <property type="gene ID" value="CP523_03435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61748">
        <property type="protein sequence ID" value="QAS61748"/>
        <property type="gene ID" value="EI377_13960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="379" mass="42416" checksum="10AC360E07EF524A" modified="2018-12-05" version="1">MILLSMINKEVKQFFRYKGNVIMLFIFPLVLITCLVFALKGVMGGELNIFKDTKVLYKVEEKSKYYHGFEIFKNKFNKISSVEFKEVGNTDQAKALVDERQAIGYISINEEGYNFYRRKSGETTAGKIFRGVFEQTLANYSLVDTILEEDPTRLQEVLKEESNKYVSEGSIGGKGITSFEYYTFAELALIILYISITIAYSVYEENKLTTINRIRISKSNDFQLIFSKGIVGIIIAILQIVEVYIFSTFILNVEWGDKLPIMVLVLISLSIFSSVIGIIVGLLARDSKNINGILNSSIIVICMLGGCYAPLSMIKSIPILSSLVKVSPVYWANTALISLNTGVDNNSGLTSILVSLILSLVLVLSYFFIRKIKGGKIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEE4</accession>
    <name>A0A386PEE4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LD-carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_01555</name>
        <name evidence="7" type="ORF">EI377_12075</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675661.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00864"/>
    <dbReference type="EnsemblBacteria" id="AYE33238">
        <property type="protein sequence ID" value="AYE33238"/>
        <property type="gene ID" value="CP523_01555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61410">
        <property type="protein sequence ID" value="QAS61410"/>
        <property type="gene ID" value="EI377_12075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="172"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="32170" checksum="11A2ABCEBC435D34" modified="2018-12-05" version="1">MKLLLKSGDKVGIIACSNGLDEKISIKIKALEEKLTSINVDMVYAKTLYKKYSVFSGSNKERADSLMELFLNPSVKAIFDVSGGDLANGVLDYLDFDKIKENSKPFFGYSDLSVLLNSLYKKSQIKTYHYQLRNLVSEYGEKQFIDFKNTFIKGENSLLDFKYNFIQGNSMEGILIGGNIRCLLKLAGTEYMPDFKNKILFLESLSGDVAKITTFLTQYKQLGILKEVKGILLGTFTEMERENYSPNIIDILKDILDDPNIPIAKTNEIGHSGNSKALIIGQFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEF2</accession>
    <name>A0A386PEF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02505</name>
        <name evidence="2" type="ORF">EI377_13040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673947.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00466"/>
    <dbReference type="EnsemblBacteria" id="AYE33411">
        <property type="protein sequence ID" value="AYE33411"/>
        <property type="gene ID" value="CP523_02505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61585">
        <property type="protein sequence ID" value="QAS61585"/>
        <property type="gene ID" value="EI377_13040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="146" mass="16683" checksum="3CB28AABC6749F69" modified="2018-12-05" version="1">MIPVLILIIGILLIGLNLKVIKKEDNSFNDILKREENNNNRDYDLEIISIRKDMAESILDIQKEMESMKISIENIKKTKEKDDNNSENVKLYENGVISNIKFPNNLSKKDKTEQVKALLKQGLSDEEVCEKLSIGRGEVLLIKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ1</accession>
    <name>A0A386PEJ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flgM</name>
        <name evidence="8" type="ORF">CP523_02715</name>
        <name evidence="9" type="ORF">EI377_13240</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676954.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00949"/>
    <dbReference type="EnsemblBacteria" id="AYE33451">
        <property type="protein sequence ID" value="AYE33451"/>
        <property type="gene ID" value="CP523_02715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61622">
        <property type="protein sequence ID" value="QAS61622"/>
        <property type="gene ID" value="EI377_13240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="7">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="91" mass="10316" checksum="6CF8DA542506C71D" modified="2018-12-05" version="1">MDIKGIGITNRINSYNKISTNKVNNVANKVTKDRIEISKEAKALRDYGIDKSEFDREKKVSEIRTKLSNGTYNVDAKLTAKAMLDHMRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN4</accession>
    <name>A0A386PEN4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HlyD family efflux transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02930</name>
        <name evidence="3" type="ORF">EI377_13455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677023.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00992"/>
    <dbReference type="EnsemblBacteria" id="AYE33491">
        <property type="protein sequence ID" value="AYE33491"/>
        <property type="gene ID" value="CP523_02930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61662">
        <property type="protein sequence ID" value="QAS61662"/>
        <property type="gene ID" value="EI377_13455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="31186" checksum="BF153CAAE1414FB8" modified="2018-12-05" version="1">MKKKRLLMYIAFFILVGIILSLTIIKKSDVIKVKVYSVRKGNIARYINTTGIVQSKSKQEYYAGQFKIVSLDVNVGDKVEKGQQLAKLEVGNIISDNTGTVTEINASEGGYTNPSYPLIVVQDINNLKLRILLNQYDSKYVNLNQLAIVKSNNENIEGKVSFISPVAKNISGSIDGEPYLDADIEGLNSVNNLKIGFKNEVDILVGEKNDVVVVPTESIKIEKGNKNYVFVCTNNVIEKREVKVGLEGEMDMEILEGIEVGEEVVLNPSGELNNGDRVKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ5</accession>
    <name>A0A386PEQ5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigG</name>
        <name evidence="8" type="ORF">CP523_01080</name>
        <name evidence="9" type="ORF">EI377_11575</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674470.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02303"/>
    <dbReference type="EnsemblBacteria" id="AYE33146">
        <property type="protein sequence ID" value="AYE33146"/>
        <property type="gene ID" value="CP523_01080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61316">
        <property type="protein sequence ID" value="QAS61316"/>
        <property type="gene ID" value="EI377_11575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014212">
        <property type="entry name" value="RNA_pol_sigma-G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02850">
        <property type="entry name" value="spore_sigG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="257" mass="29506" checksum="03D7A979858399D9" modified="2018-12-05" version="1">MIINKVEICGVNTSKLPILKEKEKRELLLSMRAGDNTARETFIKGNLRLVLSVIQRFNNRGENVDDLFQVGCIGLMKAIDNFDLSQNVKFSTYAVPMIIGEIRRYLRDNNSIRVSRSLRDIAYKALLVRDRLIKDNNKEPTVSQIAKELNLPREEVVFALDAIQDPVSLFEPIYHDGGDAIYVMDQISDSKNSDENWLENISIKEAMKKLNDREKLILTLRFFNGRTQMEVADEIGISQAQVSRLEKTALKHMKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ8</accession>
    <name>A0A386PEQ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05265</name>
        <name evidence="6" type="ORF">EI377_15825</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676264.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01842"/>
    <dbReference type="EnsemblBacteria" id="AYE33927">
        <property type="protein sequence ID" value="AYE33927"/>
        <property type="gene ID" value="CP523_05265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62078">
        <property type="protein sequence ID" value="QAS62078"/>
        <property type="gene ID" value="EI377_15825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="261" mass="28406" checksum="A5DC1E9A54315FF0" modified="2018-12-05" version="1">MKHAKGIVHKRQQAILQYLKENKTIKTDELSKILSVSPITIRRDIQLFEDQGIVERFYGGATLIEGALNDDPSLLDSSNKYLSQKEAIAKYAASLIENGDTIFINSSSTALLALQYLENKRVTVITNNGNALVAAKSPNVELVLTGGEVNERKKTMVGDFATHIINKITADKCILGVSGISAEYGIGTSVLQETTINETMLRRCTGAKIIVADSSKVGKEHNFSSGLISDISHLVTDIYADPNQLSLLNNKGVIIKTVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV1</accession>
    <name>A0A386PEV1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonine/serine exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00385</name>
        <name evidence="4" type="ORF">EI377_10875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00588"/>
    <dbReference type="EnsemblBacteria" id="AYE33012">
        <property type="protein sequence ID" value="AYE33012"/>
        <property type="gene ID" value="CP523_00385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61181">
        <property type="protein sequence ID" value="QAS61181"/>
        <property type="gene ID" value="EI377_10875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="9"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="27554" checksum="442843E9D9CE3EA7" modified="2018-12-05" version="1">MDINQILYVAMYAGKIMLESGAETYRVEETIDRICKSYGIAEVDSYATPTVIIVSVYSKGHTSSLVRRISSISVDLNKIDMVNNLSRNIERENLSIYDLEDRLKIIESKERYSFKITLLFSALGAFGFVFLFGGSFVDAISAFFIGFIVKYVTIKGSEIKINPFFINSISAGVLAFFAILSVKIGLASDIDKVIIGSIMLLVPGLSITNAIRDTVAGDLVSGLARGTDAFLTAIAIAIGTGAVLSLWINIFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF24</accession>
    <name>A0A386PF24_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cation-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09525</name>
        <name evidence="10" type="ORF">EI377_04270</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02611"/>
    <dbReference type="EnsemblBacteria" id="AYE34643">
        <property type="protein sequence ID" value="AYE34643"/>
        <property type="gene ID" value="CP523_09525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60042">
        <property type="protein sequence ID" value="QAS60042"/>
        <property type="gene ID" value="EI377_04270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
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            <end position="75"/>
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            <end position="99"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="296"/>
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        <source>
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        </source>
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    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="888" mass="97455" checksum="0147CD31624FB14C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF37</accession>
    <name>A0A386PF37_CLOSE</name>
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        <submittedName>
            <fullName evidence="10">PTS sugar transporter subunit IIC</fullName>
        </submittedName>
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        <name evidence="10" type="ORF">CP523_03735</name>
        <name evidence="11" type="ORF">EI377_14265</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
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        <property type="gene ID" value="CP523_03735"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61805"/>
        <property type="gene ID" value="EI377_14265"/>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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            <end position="41"/>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="355" mass="37010" checksum="5B3AF73C121B43AB" modified="2018-12-05" version="1">MAENKKITPKDFLNKVLAGTALGIIVGLIPNAVLASILKLFEQTDFVVLLTRTVVMFQLTTPLLIGALIALQFGLNPMKMAVVAGAAFVGSGVTMFNPQMQNMATNAMGAYVSTGTGDIINTMLTASLAVMLILLIGEKFGSVGIILTPILIGAGSGLIGLLILPYVKRFTALIGNGINSFTNLQPIVMSILIACSFAILIISPISTVAIGMAIQLNGISAGAAAMGVAATTIVLVVHSWKVNKPGLTMAVGLGAMKMMMPNLFRYPIILVPVLFTAAISAIPVALFNVMGTPSSSGFGLVGLVGPLASINAGLNIIVALMVWFVIPTLASILSLVLFEKVLKLYKKEEAFAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF96</accession>
    <name>A0A386PF96_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ORF">CP523_05200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
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    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01829"/>
    <dbReference type="EnsemblBacteria" id="AYE33914">
        <property type="protein sequence ID" value="AYE33914"/>
        <property type="gene ID" value="CP523_05200"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:removal of superoxide radicals"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="6"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="5">
        <location>
            <begin position="481"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="556" mass="60999" checksum="AAE1838FE44A82F9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF99</accession>
    <name>A0A386PF99_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10145</name>
        <name evidence="4" type="ORF">EI377_04945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676611.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00358"/>
    <dbReference type="EnsemblBacteria" id="AYE34735">
        <property type="protein sequence ID" value="AYE34735"/>
        <property type="gene ID" value="CP523_10145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60136">
        <property type="protein sequence ID" value="QAS60136"/>
        <property type="gene ID" value="EI377_04945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="383" mass="43398" checksum="0CEEC4C11FFF6F81" modified="2018-12-05" version="1">MDKKKIITIFGTRPEAIKMAPLVKELEKRKGFEAKVCVTAQHREMLDQVLDYFDIVPDFDLNIMKSKQTLTGITNKVLEGLEEIFIQEKPDMVLVHGDTTTTFSGALAAFYQKVSVGHVEAGLRTFDKYFPFPEEMNRKLTGALADLHFAPTKGSKNNLLREGINDKDIYITGNTVIDAMLHTVKDNYIFDNKELNEIDFINKKVIMITAHRRENWGKGIENICDALKIIVEKNKDVELVYLVHLNPVVKDVVNKKLGNLERVHLLDPLDTKETHNLMNKCFMVMTDSGGLQEEAPHLGKPVLVLRDVTERPEAVSYGTVKLVGTDIEKIVDEANKLLTNTEAYNIMSKSVNPYGDGLASKRIADAIEKYFGIREEKIEEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE3</accession>
    <name>A0A386PFE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33964">
        <property type="protein sequence ID" value="AYE33964"/>
        <property type="gene ID" value="CP523_05490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="77" mass="8647" checksum="84A0CCDEDB67CF3F" modified="2018-12-05" version="1">MLLTLFRNKIPFAAPTTPSIGWLTNSKISFAAPTSASPIPNKKLIVTLFIVINSLFLFILSFQFFLFLSETLNFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE7</accession>
    <name>A0A386PFE7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-sigma F factor</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Stage II sporulation protein AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIAB</name>
        <name evidence="5" type="ORF">CP523_02360</name>
        <name evidence="6" type="ORF">EI377_12880</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anti-sigma-factor family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00495"/>
    <dbReference type="EnsemblBacteria" id="AYE33386">
        <property type="protein sequence ID" value="AYE33386"/>
        <property type="gene ID" value="CP523_02360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61557">
        <property type="protein sequence ID" value="QAS61557"/>
        <property type="gene ID" value="EI377_12880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042174">
        <property type="term" value="P:negative regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00637">
        <property type="entry name" value="Anti_sigma_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010194">
        <property type="entry name" value="Anti-sigma_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01925">
        <property type="entry name" value="spIIAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="145" mass="15898" checksum="D9401F9BE3559082" modified="2018-12-05" version="1">MIDVDNKISIELMSKSENEGFARVAVAAFVSQLDPTVEEITDVKTAVSEAVTNSIIHGYENRKEGIIKIEAYIVGAEVVITIEDSGRGISNVEQAMEPLYTSRPELERSGMGFTVMESFMDSLEVESKEGVGTKVVMKKKFNTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH8</accession>
    <name>A0A386PFH8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1292 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10535</name>
        <name evidence="2" type="ORF">EI377_05320</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674189.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01393"/>
    <dbReference type="EnsemblBacteria" id="AYE34803">
        <property type="protein sequence ID" value="AYE34803"/>
        <property type="gene ID" value="CP523_10535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60198">
        <property type="protein sequence ID" value="QAS60198"/>
        <property type="gene ID" value="EI377_05320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="25701" checksum="B4044C40937C5474" modified="2018-12-05" version="1">MANNSDFIKEELDHFGKIYTDLTYAISEISPFLDENELIKRKYYSKISILKTYIEKLNISKTKSQKKKLINFFSTNNSHEDLKIFKNDNRESFLQFENCSKCACLNCIRECEFKGCLGCRSNSYIKKCDKNKINIRKHKNFFLDLTNNNTGKSSKYNVLATLEDKQLDKLYIILENIEDNTDKYILYYYPSISSDEFGEITDTSEFDFIVNTFEQSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY3</accession>
    <name>A0A386PFY3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02665</name>
        <name evidence="2" type="ORF">EI377_13190</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676941.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33442">
        <property type="protein sequence ID" value="AYE33442"/>
        <property type="gene ID" value="CP523_02665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61613">
        <property type="protein sequence ID" value="QAS61613"/>
        <property type="gene ID" value="EI377_13190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="107" mass="12686" checksum="0097F424A7A56CD4" modified="2018-12-05" version="1">MLRSLLEEYKKITDEIFCEVSGNCDVEDLLDKRQKIIESLFENFNKDSIKNEYLGLGLKELDDNLYDAMAKEKNKVKSELLKLKKVRAARQCYEQNIRKNNFFNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG04</accession>
    <name>A0A386PG04_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF814 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10070</name>
        <name evidence="5" type="ORF">EI377_04870</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676579.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00343"/>
    <dbReference type="EnsemblBacteria" id="AYE34720">
        <property type="protein sequence ID" value="AYE34720"/>
        <property type="gene ID" value="CP523_10070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60121">
        <property type="protein sequence ID" value="QAS60121"/>
        <property type="gene ID" value="EI377_04870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="329" mass="37201" checksum="A3DEB709CC2AEE56" modified="2018-12-05" version="1">MAKALAMISGGLDSILAAKLIKDQGIEVIGICFKSYFFSEESAKRMTKQIDIPLEVIDFSEEHMNMVKNPKHGWGKNMNPCIDCHAMMMRYSGKLLEQFNADFIITGEVLNQRPMSQNRQALNIVKKESGFADKILRPLCAKNLDETEMERSGLVDREKLLNITGRSRKAQMELASKWGITEYPSPAGGCKLTEPGYAIRLKDSLDNSEFISENEIELLRYGRHFRVSENAKIIAARTGDEVKEIKKYIDDSFIAMNASKYTGALVIIQGKPTEKEIELGARIAARYSKGRDEEEVEVMYGVYGKKFNDFIKVSPITDEELQQYLIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG19</accession>
    <name>A0A386PG19_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recJ</name>
        <name evidence="10" type="ORF">CP523_02820</name>
        <name evidence="11" type="ORF">EI377_13345</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676989.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00970"/>
    <dbReference type="EnsemblBacteria" id="AYE33472">
        <property type="protein sequence ID" value="AYE33472"/>
        <property type="gene ID" value="CP523_02820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61643">
        <property type="protein sequence ID" value="QAS61643"/>
        <property type="gene ID" value="EI377_13345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="7">
        <location>
            <begin position="78"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="8">
        <location>
            <begin position="327"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="9">
        <location>
            <begin position="462"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="591" mass="67539" checksum="4FB939FFE2B702B6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG34</accession>
    <name>A0A386PG34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11575</name>
        <name evidence="2" type="ORF">EI377_06390</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673344.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35003">
        <property type="protein sequence ID" value="AYE35003"/>
        <property type="gene ID" value="CP523_11575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60396">
        <property type="protein sequence ID" value="QAS60396"/>
        <property type="gene ID" value="EI377_06390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="64" mass="7358" checksum="AE32DF3B4878E05B" modified="2018-12-05" version="1">MGMEKLERKMKSLYKQVKSGKVTAEIADEIADMMDSIEDMGSDVKEKFSDMIDDMKKSMSKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC8</accession>
    <name>A0A386PGC8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07380</name>
        <name evidence="3" type="ORF">EI377_02070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673772.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01085"/>
    <dbReference type="EnsemblBacteria" id="AYE34284">
        <property type="protein sequence ID" value="AYE34284"/>
        <property type="gene ID" value="CP523_07380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59678">
        <property type="protein sequence ID" value="QAS59678"/>
        <property type="gene ID" value="EI377_02070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="23606" checksum="4E50E0FB4251E9FB" modified="2018-12-05" version="1">MDNNVKWVNEQRILRTIEALKSNNMNGYLVSNKAELLAKIEELVKEGSTVSCGGSVSLAESGVLDYLRSGKYNFLDRGKEGLTQEEIGKIYRGAFSADAYFTSSNAITEAGELYNVDGNGNRVAAMIFGPERVIVIVGVNKLVKDVDEAINRVKYVAAPANGVRLNRQTPCAKVGYCMDCKSKTRMCRQYTLIKSQSNPDRMHVIFINEELGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI2</accession>
    <name>A0A386PGI2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">tuf</name>
        <name evidence="10" type="ORF">CP523_08890</name>
        <name evidence="11" type="ORF">CP523_08955</name>
        <name evidence="12" type="ORF">EI377_03645</name>
        <name evidence="13" type="ORF">EI377_03710</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01778"/>
    <dbReference type="EnsemblBacteria" id="AYE34524">
        <property type="protein sequence ID" value="AYE34524"/>
        <property type="gene ID" value="CP523_08890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34537">
        <property type="protein sequence ID" value="AYE34537"/>
        <property type="gene ID" value="CP523_08955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59926">
        <property type="protein sequence ID" value="QAS59926"/>
        <property type="gene ID" value="EI377_03645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59939">
        <property type="protein sequence ID" value="QAS59939"/>
        <property type="gene ID" value="EI377_03710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08890"/>
    <dbReference type="KEGG" id="csep:CP523_08955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="397" mass="43663" checksum="D6EAD4DE8D7BDCEB" modified="2018-12-05" version="1">MAKQKFERSKPHVNIGTIGHVDHGKTTLTAAITTVLANRGLAESFKYDEIDKAPEEKERGITINTAHVEYQTDNRHYAHVDCPGHADYVKNMITGAAQMDGAILVCSAADGPMPQTREHILLASRVGVDYIVVFLNKADMVDDEELLELVEMEVRELLSEYNFPGDDIPVIKGSALVALENPTDEKSIAPILELMEAVDSYIPTPERATDKPFLMPVEDVFTITGRGTVATGRVERGVLHVGDEVEIVGLSEESRKVVVTGIEMFRKLLDEAQAGDNVGVLLRGVQRTDIERGQVLAKTGSVKPHSKFVGQVYVLKKEEGGRHTPFFDGYRPQFYFRTTDVTGSIKLPDGMEMVMPGDHIDMNVELITQVAMDEGLRFAIREGGRTVGSGVVTSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ3</accession>
    <name>A0A386PGJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05650</name>
        <name evidence="2" type="ORF">EI377_00080</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33988">
        <property type="protein sequence ID" value="AYE33988"/>
        <property type="gene ID" value="CP523_05650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59351">
        <property type="protein sequence ID" value="QAS59351"/>
        <property type="gene ID" value="EI377_00080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="14451" checksum="7EE85D642951936F" modified="2018-12-05" version="1">MNIEILEKKLGFDGFQYPDSFIKAIELNLLDFDLWYIMDEERVLNRLKGVTERYPNRKLIPFARRDDNDDIACFEVGKDEKVQIIHDFASEGYEQRKEYNDFWDWLKDAIDEMIEFNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ4</accession>
    <name>A0A386PGJ4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">CP523_09005</name>
        <name evidence="13" type="ORF">EI377_03750</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678358.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00241"/>
    <dbReference type="EnsemblBacteria" id="AYE34547">
        <property type="protein sequence ID" value="AYE34547"/>
        <property type="gene ID" value="CP523_09005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59947">
        <property type="protein sequence ID" value="QAS59947"/>
        <property type="gene ID" value="EI377_03750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="24567" checksum="9F8901A373D2B896" modified="2018-12-05" version="1">MGQKVHPHGLRVGVIKDWDAKWYASKKNFADNLIEDNKIREFVKKDLYSAGISKIEIERAAKRIKLNIHTAKPGVIIGKGGSGIEALKVKLAKIVSNKNILINIVEVRNADANAQLMAENIAAQLEKRVSFRRAMKQSIQRGMRLGAKGVKTACSGRLGGAEIARTEQYHEGTIPLQTLRADIDYGFAEADTTYGKIGVKVWVYNGEVLPTKKVEKKEEVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM4</accession>
    <name>A0A386PGM4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermidine/putrescine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02060</name>
        <name evidence="4" type="ORF">EI377_12580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678869.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00120"/>
    <dbReference type="EnsemblBacteria" id="AYE33329">
        <property type="protein sequence ID" value="AYE33329"/>
        <property type="gene ID" value="CP523_02060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61499">
        <property type="protein sequence ID" value="QAS61499"/>
        <property type="gene ID" value="EI377_12580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362715" evidence="2">
        <location>
            <begin position="26"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="356" mass="40738" checksum="215DBAEE7C61740B" modified="2018-12-05" version="1">MKKHKKLISLIIATVFSSTLFVSCNKDFKSSSKDSKVINVFNAGDYINPDLIGKFESETGIKVIYNTYDTNEIMYQKVKTSPGTYDLVFPSDYMVEKMIKENMAERIDFNNIPNYNNIGDDYKNLSYDPNNEYSIPYMWGTIGIIYNADKIKNPIDSWNDLWNPAYKNEIFMFDSIRDTLAIALLKLGYSQNSVNPKEIDEASEELIKQKPLVQSYVVDEVKDKMINAEAAIATVWSGDAVYIQEEAPDLNLKYVVPKEGSNKWFDTMVIPKNAPNKTGAEEFINFLLDAENAKENVEYIGYATPNLAAYALLDEETQKDETVYPKKEVLNKCEIFKDLGDKLKLYDDAWLKVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW7</accession>
    <name>A0A386PGW7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cadmium-translocating P-type ATPase</fullName>
            <ecNumber evidence="9">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cadA</name>
        <name evidence="8" type="ORF">CP523_09545</name>
        <name evidence="9" type="ORF">EI377_04290</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02615"/>
    <dbReference type="EnsemblBacteria" id="AYE34647">
        <property type="protein sequence ID" value="AYE34647"/>
        <property type="gene ID" value="CP523_09545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60046">
        <property type="protein sequence ID" value="QAS60046"/>
        <property type="gene ID" value="EI377_04290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="744" mass="81305" checksum="FD520F1AD04D8FB6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY1</accession>
    <name>A0A386PGY1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsF</name>
        <name evidence="6" type="ORF">CP523_07570</name>
        <name evidence="7" type="ORF">EI377_02260</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673826.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01123"/>
    <dbReference type="EnsemblBacteria" id="AYE34311">
        <property type="protein sequence ID" value="AYE34311"/>
        <property type="gene ID" value="CP523_07570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59705">
        <property type="protein sequence ID" value="QAS59705"/>
        <property type="gene ID" value="EI377_02260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="95" mass="10898" checksum="32F1726C3B908DEB" modified="2018-12-05" version="1">MRKYETIFILHPSLDEEACKANIEKFKGVIENGGGTIENVDVWGKRKLAYEISKVNEGFYTLINFNADADLPKELDRIFRITDGVLRHIIVKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH11</accession>
    <name>A0A386PH11_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1667 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07810</name>
        <name evidence="2" type="ORF">EI377_02500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679160.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02105"/>
    <dbReference type="EnsemblBacteria" id="AYE34341">
        <property type="protein sequence ID" value="AYE34341"/>
        <property type="gene ID" value="CP523_07810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59737">
        <property type="protein sequence ID" value="QAS59737"/>
        <property type="gene ID" value="EI377_02500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="8585" checksum="747D57E1B7D48042" modified="2018-12-05" version="1">MDKDVFTSIVRVKGSDKYKVVSVKSSEEVDKKLWVELSKVLGRIYVNIPINSGDIICKNILNTGINIICTRTLEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH99</accession>
    <name>A0A386PH99_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14015</name>
        <name evidence="5" type="ORF">EI377_08920</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678641.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00220"/>
    <dbReference type="EnsemblBacteria" id="AYE35453">
        <property type="protein sequence ID" value="AYE35453"/>
        <property type="gene ID" value="CP523_14015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60841">
        <property type="protein sequence ID" value="QAS60841"/>
        <property type="gene ID" value="EI377_08920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="467" mass="54446" checksum="35AF4504D9D9F040" modified="2018-12-05" version="1">MGIDFNVLFEEEIPKYIQISNHIKKLIDNKEIQDGEKLPTIRKLSLELGVNNVTIVNAYKKLKNDGYAYQKVGSGTYAKRKDILPIFNREYNRCFKKLNEKELNNIIDFSGETSTEVYFPINKFKDVMNRVLDRDGANALIMKEPLGYEELRKTINNSFWNNSLNLDNILVVSGAQQGIDIASKAILNINDNVIVEKPTYGGALSVFKWRRANIFEVNLDKDGINVKEFEEILKKNKIRCFYTMSYFHNPTGISCSREKKIKLLELAEKYDFYIIEDDYLSELIYEDGHVHEPLKKLDKNDRVVYIKSFSKIFLPGIRLGYIITPECFRESIQNSKISTDIATSSLMQRALELYIKDGFWKGHINFQKEEYKKKYLLMKKLIEENLSDKVKFIDPKGGLNFYLELKDKKYTSKGLFYLLKEKGIYITPGVIFFRYPSDGAYTFRIGFSQVDEEKIIKGIKIIREELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB6</accession>
    <name>A0A386PHB6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybaK</name>
        <name evidence="5" type="ORF">CP523_10445</name>
        <name evidence="6" type="ORF">EI377_05220</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674226.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01411"/>
    <dbReference type="EnsemblBacteria" id="AYE34787">
        <property type="protein sequence ID" value="AYE34787"/>
        <property type="gene ID" value="CP523_10445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60182">
        <property type="protein sequence ID" value="QAS60182"/>
        <property type="gene ID" value="EI377_05220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="36"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="158" mass="17907" checksum="2A4CBA930735C6D8" modified="2018-12-05" version="1">MAKVKTNAIRILEKNNVKYEIITYDSKDGKIDGISVAEKINRNIEEVYKTLVTIGNSNELYVFVIPVDKELDLKKAAKIVEEKKIEMIHVKDILKYTGYIRGGCSPFGMKKQYKTFVNDTAKNLEKVIVSGGKIGIQVEINPEALIEILDVKFQDIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC1</accession>
    <name>A0A386PHC1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YitT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09190</name>
        <name evidence="10" type="ORF">EI377_03935</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678341.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03060"/>
    <dbReference type="EnsemblBacteria" id="AYE34584">
        <property type="protein sequence ID" value="AYE34584"/>
        <property type="gene ID" value="CP523_09190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59984">
        <property type="protein sequence ID" value="QAS59984"/>
        <property type="gene ID" value="EI377_03935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="31232" checksum="B625E11B93E2CE6A" modified="2018-12-05" version="1">MLSKLKENKTVLLDFFLMVVGCLIASLGVNLFLVNARLLSGGATGVALILEYAAGVPSGVTVFIINIPLFFLSYKMLSRRFTIYSAIGMVSLSLSLIITKPLSQLVRVDDILLYCIYGGVMCGLGYGLVFLRNGSTGGTDILAMVLRKKYSNLEIGKLSFSINFIIVIIGAIIFGLPKALYTLISIFIQGIVVDKVISGFNSKKLLLVLSDKEQDIVNYVIKDLHRGATSLLAQGEYTHEFKKMLYIAVTSSQMISLKNKILKIDPKAFISILDVSEVNGKGFHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ3</accession>
    <name>A0A386PHJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01471"/>
    <dbReference type="EnsemblBacteria" id="AYE33649">
        <property type="protein sequence ID" value="AYE33649"/>
        <property type="gene ID" value="CP523_03780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="610" mass="71977" checksum="0592E1D7AF8AA5B0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL3</accession>
    <name>A0A386PHL3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06050</name>
        <name evidence="4" type="ORF">EI377_00530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675096.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01911"/>
    <dbReference type="EnsemblBacteria" id="AYE34062">
        <property type="protein sequence ID" value="AYE34062"/>
        <property type="gene ID" value="CP523_06050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59433">
        <property type="protein sequence ID" value="QAS59433"/>
        <property type="gene ID" value="EI377_00530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025991">
        <property type="entry name" value="Chemoreceptor_zinc-bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13682">
        <property type="entry name" value="CZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="74"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="449" mass="50763" checksum="CE617005F6584B0E" modified="2018-12-05" version="1">MIFKRKKNIEISASNYNLNKILLEKISERKLLSCDDFYDKSLIETLNILLNSYYDNTSVMCINDIVKNIMEIDSIDNMLSNSSSQKDIIQSIVASSEELASTTEHVALSIENVSQHSTDVKNEAIDSMESINNIIDYIINSSSNVFKIKENINLVAKKVNDINEIVRIIKQIANQTSLLSLNASIEAARAGKSGKGFTVVANEIKNLAEYTKKSVETISDDILELSNSTNETLGHTNVTIEDLNSGINKMESIPIYMNNIIESIKEIDEEFCNISAISEEQSATTSMIADKLTNIAEFQITLDNMCKDVADKINKTSDYSNNIRMKQIDSNNLTLSEKLDTYVVDHLLWRWKIYNMILGLEDINENNASNYKDCALGKWFYNETDPNITKTFSFRKLEGVHIELHKEASNAVKCYRQKNIDGCYTHLNNMTGISSTIIHLINDLKEHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM1</accession>
    <name>A0A386PHM1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rsmH</name>
        <name evidence="7" type="ORF">CP523_14850</name>
        <name evidence="8" type="ORF">EI377_09805</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676097.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01313"/>
    <dbReference type="EnsemblBacteria" id="AYE35605">
        <property type="protein sequence ID" value="AYE35605"/>
        <property type="gene ID" value="CP523_14850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60992">
        <property type="protein sequence ID" value="QAS60992"/>
        <property type="gene ID" value="EI377_09805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="310" mass="35163" checksum="9C6453DF5FFE67A5" modified="2018-12-05" version="1">MEFKHVSVLLNECIEGLNIKSNGIYVDGTLGGAGHSSHIIKNLSNEGRLIGIDQDKDALKAAGKRLQNYKNVTFVHSNFYNVKNVLDNLNIEKIDGMLLDLGVSSYQLDTGERGFSYMQDAPLDMRMNRENSFSAYEVVNDYSEDELYRIIRDYGEEKFARRIAQFIVNRREEKKIETTLELVEIIKNAIPAKARREGPHPAKRTFQAIRIEVNSELSILNKTIEDAVMKLNKGGRLAIITFHSLEDRIVKVKFKELATSCTCPKEFPICVCGGKAKVKLVSRKAIEPTKEEVEENPRSRSAKLRVIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP5</accession>
    <name>A0A386PHP5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_04040</name>
        <name evidence="12" type="ORF">EI377_14560</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676919.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02778"/>
    <dbReference type="EnsemblBacteria" id="AYE33699">
        <property type="protein sequence ID" value="AYE33699"/>
        <property type="gene ID" value="CP523_04040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61854">
        <property type="protein sequence ID" value="QAS61854"/>
        <property type="gene ID" value="EI377_14560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="139"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="238" mass="27720" checksum="432C81A9FE036935" modified="2018-12-05" version="1">MDKEKILIVDDEKEIRDLVEIYLKGEGYNTLKAENGEEALDILKTNEVDLIILDIMMPKLNGIEACLKIREEREMPIIMLSAKSEDMDKILGLNTGADDYLTKPFNPLELVARVKSQLRRYKRFNNITIAEESKITKHINILEIDEITINLDTHEVFKEGVEIKLTPTEFDILVLLGTNRGKVFSIENIYNSVWKQDFMQSDNTVMVHIRKVREKIEHDPRNPRYIKTVWGVGYKIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ7</accession>
    <name>A0A386PHQ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10040</name>
        <name evidence="2" type="ORF">EI377_04840</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676567.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00337"/>
    <dbReference type="EnsemblBacteria" id="AYE34714">
        <property type="protein sequence ID" value="AYE34714"/>
        <property type="gene ID" value="CP523_10040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60115">
        <property type="protein sequence ID" value="QAS60115"/>
        <property type="gene ID" value="EI377_04840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009366">
        <property type="entry name" value="Protein_Veg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40026">
        <property type="entry name" value="PTHR40026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06257">
        <property type="entry name" value="VEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037257">
        <property type="entry name" value="DUF1021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="78" mass="8822" checksum="42B9CEB93D71D687" modified="2018-12-05" version="1">MEKLKTIATIKKDIENHIGEKVTLKANGGRKKILVNNGVIESTYPSIFVVRLESDTQRTVTYSYSDVLTKTVQLYFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR4</accession>
    <name>A0A386PHR4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06375</name>
        <name evidence="8" type="ORF">EI377_00845</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02434"/>
    <dbReference type="EnsemblBacteria" id="AYE34122">
        <property type="protein sequence ID" value="AYE34122"/>
        <property type="gene ID" value="CP523_06375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59488">
        <property type="protein sequence ID" value="QAS59488"/>
        <property type="gene ID" value="EI377_00845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="243" mass="28876" checksum="BA4A9B7D71D05FEE" modified="2018-12-05" version="1">MGCNMNILIVEDMKDQREALKKIIEEEFKSITIYLAPSLETALEITNIENIDLFMFDVNLQGRTGIELAEKIRCNNKYKLTPIVFITIESGKMIDAFKNIHCYDFIIKPYRKEEIKKIINTFLEAQSVSEKMHNKYTFFNISPLISVKIYHKDIIFIEYYLRKCTIYTIKDKYDVKVRGLNNLIKEIDSEYIVQSHKSYAINLNYIEKIEKVYPKLWNIYFTNCSEIAKLGYKYKNNIYEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU9</accession>
    <name>A0A386PHU9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore protease YyaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yyaC</name>
        <name evidence="1" type="ORF">CP523_10240</name>
        <name evidence="2" type="ORF">EI377_05045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674309.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01447"/>
    <dbReference type="EnsemblBacteria" id="AYE34754">
        <property type="protein sequence ID" value="AYE34754"/>
        <property type="gene ID" value="CP523_10240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60154">
        <property type="protein sequence ID" value="QAS60154"/>
        <property type="gene ID" value="EI377_05045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009665">
        <property type="entry name" value="DUF1256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06866">
        <property type="entry name" value="DUF1256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02841">
        <property type="entry name" value="spore_YyaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="176" mass="19282" checksum="34A93360ED20BB69" modified="2018-12-05" version="1">MVKHKVFYESDLAYYEIANVLKNYISKNTVIVCIGTDKCIGDCLGPLVGTYLIENNCDLPVYGTIESPIHALNIEKRLSQIKKLHPNSTIIGIDACLGDTKSIGEIHIRNYPIHPGKGVGKLLPDVGSASIIGIVESSDNAEFFTSRSIRLHLIMSMAKVISKGISKAYYLSNITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW1</accession>
    <name>A0A386PHW1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10320</name>
        <name evidence="6" type="ORF">EI377_05100</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674277.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34764">
        <property type="protein sequence ID" value="AYE34764"/>
        <property type="gene ID" value="CP523_10320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60163">
        <property type="protein sequence ID" value="QAS60163"/>
        <property type="gene ID" value="EI377_05100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06920">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006635">
        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037250">
        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05031">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00725">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158911">
        <property type="entry name" value="SSF158911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50978">
        <property type="entry name" value="NEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="NEAT" evidence="4">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="23742" checksum="CF9C0CFFE0936E12" modified="2018-12-05" version="1">MKYLRIIFSVFLIGMFVSMFGVNTKAIESKEIESGIYELENDVYHNSEIGRSMARTYLNNIMTLEAKGGNMFCTIEFSSSDYMENYRMIIDEKEVESEIVDKNEENKTVKIKFKINSLDSKINANMYVIPMGRDVSFDIIPKKDTLKLIEKIEEPKAESDDSKTNDAVENNQKESKEKTSIITFGAIIIGLVAIVVIGSRVKNKYKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX0</accession>
    <name>A0A386PHX0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06705</name>
        <name evidence="2" type="ORF">EI377_01170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679205.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00030"/>
    <dbReference type="EnsemblBacteria" id="AYE34182">
        <property type="protein sequence ID" value="AYE34182"/>
        <property type="gene ID" value="CP523_06705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59545">
        <property type="protein sequence ID" value="QAS59545"/>
        <property type="gene ID" value="EI377_01170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="78" mass="8881" checksum="938320135AC2D27E" modified="2018-12-05" version="1">MPDYKMDIQGNLNLSEYSNIFDYMGVVDMNDSFTITLSNTSQQDINIITSMLRDGDFLIKEQGVNGNGEYYINANKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX4</accession>
    <name>A0A386PHX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01940"/>
    <dbReference type="EnsemblBacteria" id="AYE35715">
        <property type="protein sequence ID" value="AYE35715"/>
        <property type="gene ID" value="CP523_15450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="98" mass="11048" checksum="DB3769CBBAC8523A" modified="2018-12-05" version="1">MKNGIIIDVKTIPIGMLNIYQEIIDYVNYRHTESFSLNVPPVVGNECGALVPQRHGGLSYKIVENKGDIKIIDTENFGRLQIYGPNDADSDVTNYTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI68</accession>
    <name>A0A386PI68_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33859">
        <property type="protein sequence ID" value="AYE33859"/>
        <property type="gene ID" value="CP523_04905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="82" mass="9796" checksum="FE32531565E581A3" modified="2018-12-05" version="1">MKNLIKTIKFWEIIFIILLLINISPSFIEFLPITILPLTLVSIIPCILAFRERKHYIISINILIEIISVIIYIYIYIWQLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI77</accession>
    <name>A0A386PI77_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05365</name>
        <name evidence="4" type="ORF">EI377_15930</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677997.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02595"/>
    <dbReference type="EnsemblBacteria" id="AYE35825">
        <property type="protein sequence ID" value="AYE35825"/>
        <property type="gene ID" value="CP523_05365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62247">
        <property type="protein sequence ID" value="QAS62247"/>
        <property type="gene ID" value="EI377_15930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041688">
        <property type="entry name" value="PRTase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022537">
        <property type="entry name" value="TRSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011214">
        <property type="entry name" value="UCP020967"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15609">
        <property type="entry name" value="PRTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12500">
        <property type="entry name" value="TRSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020967">
        <property type="entry name" value="UCP020967"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRTase_2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="TRSP" evidence="1">
        <location>
            <begin position="256"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="382" mass="43900" checksum="72D8888F5542ABA6" modified="2018-12-05" version="1">MDIKIKSNIYNLNLNNLISLGNRVNNSKRNFLFISKVLGKHIEVKPNVCKEAGEMLASLLYKSKNSKIDNLKICVLGFAETATGLGMAVASAIKDSYYLTTTREDIAEMESILKFEEEHSHATTHKCFPIEKDYLVNADKIILVDDEITTGKSMINIIKELKRVTNAKDFSILSILDWRSDEHKRQFDKLASDENINVEVLATITGDITVNDTRVFIDNNDNVLDEKIDVIKSNKLERKVFKTITKPDGEDYLLHTGRFGVHHKEIESLEDKCKETADFIHSKIGYPKKILVLGHGENIYIPSRVASYLEGDVYYKSTTRSPIYCSNKEKYPIKQKDVFYHKGVKYYFYNRDEIENKYDKVVLLTEDDLDIKLTNNMILMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI95</accession>
    <name>A0A386PI95_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ORF">CP523_14420</name>
        <name evidence="14" type="ORF">EI377_09395</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676815.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02477"/>
    <dbReference type="EnsemblBacteria" id="AYE35530">
        <property type="protein sequence ID" value="AYE35530"/>
        <property type="gene ID" value="CP523_14420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60917">
        <property type="protein sequence ID" value="QAS60917"/>
        <property type="gene ID" value="EI377_09395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14420"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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            <end position="564"/>
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            <end position="756"/>
        </location>
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            <end position="879"/>
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            <end position="840"/>
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            <end position="58"/>
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    <sequence length="880" mass="101694" checksum="B0AB60DFF414FBD1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM4</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
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                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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            <end position="60"/>
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        <source>
            <dbReference type="SMART" id="SM00363"/>
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            <dbReference type="EMBL" id="AYE34476.1"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59878.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="86" mass="9912" checksum="D7ABEA18D15107ED" modified="2018-12-05" version="1">MRLDKYLKVSRIIKRRTVAKEACEGGRVSINDKIAKPSTVIKEGDIIEIAFANRKLKARIINIAEHVRKENAKEMYEILEGEEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW2</accession>
    <name>A0A386PIW2_CLOSE</name>
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        <submittedName>
            <fullName evidence="4">Ribosome assembly RNA-binding protein YhbY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yhbY</name>
        <name evidence="4" type="ORF">CP523_10670</name>
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    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01368"/>
    <dbReference type="EnsemblBacteria" id="AYE34828">
        <property type="protein sequence ID" value="AYE34828"/>
        <property type="gene ID" value="CP523_10670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60223">
        <property type="protein sequence ID" value="QAS60223"/>
        <property type="gene ID" value="EI377_05455"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
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    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="100" mass="11267" checksum="65BC34BBEA17D6FD" modified="2018-12-05" version="1">MLTGKQRAYLRGLANGMDPIFQLGKNGIEETFLKQIEEALEARELIKIKVLENSGLETREASNYICEKIGCEGIQAIGSKMVLYKKSLKKPKIELPITKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX0</accession>
    <name>A0A386PIX0_CLOSE</name>
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        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06085</name>
        <name evidence="2" type="ORF">EI377_00565</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675116.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01918"/>
    <dbReference type="EnsemblBacteria" id="AYE34069">
        <property type="protein sequence ID" value="AYE34069"/>
        <property type="gene ID" value="CP523_06085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59440">
        <property type="protein sequence ID" value="QAS59440"/>
        <property type="gene ID" value="EI377_00565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="223" mass="23907" checksum="086F163174FDFB27" modified="2018-12-05" version="1">MGVKKVKLVPEIKGTLRSHVIEVPTCIRECSGIKIFGKRIKSLLFTTDVAIIRNTNADAIIAVYPFTPQPLITQALVMAADVPIFCGVGGGITQGKRVVNLALDAEFKGAMGVVVNAPTANSIVKKIRETIDIPVIVTVVSECENIRERIESGATILNVSGGKNTARIVREIRAEFPDFPIIATGGPTEETIMETIEAGANAITYTPPVTGDIMSNLMDKYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY2</accession>
    <name>A0A386PIY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34089">
        <property type="protein sequence ID" value="AYE34089"/>
        <property type="gene ID" value="CP523_06190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="67" mass="8009" checksum="C1090FF115440273" modified="2018-12-05" version="1">MVNSSVEPEINSEVKPLNILNENTFESNYDYEFINFLNEFHRFINSSYYELVPSVQYNTSNLFFNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ03</accession>
    <name>A0A386PJ03_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12330</name>
        <name evidence="3" type="ORF">EI377_07220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02046"/>
    <dbReference type="EnsemblBacteria" id="AYE35141">
        <property type="protein sequence ID" value="AYE35141"/>
        <property type="gene ID" value="CP523_12330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60546">
        <property type="protein sequence ID" value="QAS60546"/>
        <property type="gene ID" value="EI377_07220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029441">
        <property type="entry name" value="Cass2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14526">
        <property type="entry name" value="Cass2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="146" mass="16662" checksum="14C72419F16E18CF" modified="2018-12-05" version="1">MNYEVVNLEEKIIVGVSATTSNDDPNMAKIIGGLWEKLYQEGINESIKNKVNEYAIGLYSDYEDNKYLVTVGNEVSKVENEGLTIKKIPSGKYAKFSIEGHIEKAVAEAWTEIWKMDLDRSYKADFEEYLNSDFDNAKIDIYISLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ04</accession>
    <name>A0A386PJ04_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome B5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08455</name>
        <name evidence="3" type="ORF">EI377_03200</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01632"/>
    <dbReference type="EnsemblBacteria" id="AYE35850">
        <property type="protein sequence ID" value="AYE35850"/>
        <property type="gene ID" value="CP523_08455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62156">
        <property type="protein sequence ID" value="QAS62156"/>
        <property type="gene ID" value="EI377_03200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="79" mass="8654" checksum="641FC8697942143C" modified="2018-12-05" version="1">MPTEFTINELQKYNGRNGMAALVAINGTVYDVADVKAWQNGVHFGVMAGKDVTKAFLNCHSENKDKILSNLRVVGTLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ60</accession>
    <name>A0A386PJ60_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09730</name>
        <name evidence="3" type="ORF">EI377_04530</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676737.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34682">
        <property type="protein sequence ID" value="AYE34682"/>
        <property type="gene ID" value="CP523_09730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60083">
        <property type="protein sequence ID" value="QAS60083"/>
        <property type="gene ID" value="EI377_04530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="99" mass="11789" checksum="A11763954D1CE581" modified="2018-12-05" version="1">MILAVQIFQIIFYSVAILFMIALTIISIWGFIIFNKMHKNQRIQNFLLDKIYQSINHLTYSKYKNSNNDNSKDSFDIDEIINEEELFKDDDNKDNIISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ79</accession>
    <name>A0A386PJ79_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3784 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06995</name>
        <name evidence="3" type="ORF">EI377_01480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673665.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34219">
        <property type="protein sequence ID" value="AYE34219"/>
        <property type="gene ID" value="CP523_06995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59584">
        <property type="protein sequence ID" value="QAS59584"/>
        <property type="gene ID" value="EI377_01480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017259">
        <property type="entry name" value="UCP037672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12650">
        <property type="entry name" value="DUF3784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="11709" checksum="CC37AEC10C24DA76" modified="2018-12-05" version="1">MLILFTSIIMMVIAISLGLLIKKGRINPYIKAYKEPLDDKSEYTFLNKVSDYLGNSFYALGLIMISFGLIDYAGYTKSIIILVIALVIWFITTFVGAQLITTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ96</accession>
    <name>A0A386PJ96_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_07115</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01038"/>
    <dbReference type="EnsemblBacteria" id="AYE34239">
        <property type="protein sequence ID" value="AYE34239"/>
        <property type="gene ID" value="CP523_07115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="413" mass="46467" checksum="14F6D8069DF05F8B" modified="2018-12-05" version="1">MESYTWQIVLLIILLVMSGFFSMSETALMALSKIRIRHMVEEGVKGAKLVEKLTEEPNKLLGAILIGNNIVNIGASALATSLALKAFGESGVGIVTVIMTVLVLIFGEITPKSIAKQKSEKVALRVSKIINLTVKIFKPFIAIFTAISGIFIKLLGCNPKASEPFIKEEELRTMVGVSEEEGVLEGVEKEMIFNVFDFVDAQVKDVMVQRVDVIAVDVNATYDEVLEVIKTEQFSRIPVYNQTIDDVVGILNVKDLIMAERNKEDFKVIDYMREPYYTFEFKKIKELFSEMKKTRNHIAVVLDEYGGNVGIVTIEDLIEEVFGDIEDEYDDENNEIEVVKEDEYIVDGSARLDDISDLIGVNMESEEFDSVGGLIIGELGRFPEQDEEITSNNIRFVVEDIDKNRIKKVRIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJA2</accession>
    <name>A0A386PJA2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ORF">CP523_14520</name>
        <name evidence="12" type="ORF">EI377_09490</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00208"/>
    <dbReference type="EnsemblBacteria" id="AYE35547">
        <property type="protein sequence ID" value="AYE35547"/>
        <property type="gene ID" value="CP523_14520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60933">
        <property type="protein sequence ID" value="QAS60933"/>
        <property type="gene ID" value="EI377_09490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14520"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="293" mass="32120" checksum="1F228796A814CB78" modified="2018-12-05" version="1">MTIFKGSAVAIITPFNNNGDVNYKKLEELLEWHISEKTDAIVICGTTGEATTMSDEEKKEVIKFTVNIINKRIPVIAGTGSNNTKAAIEMTKYAENVGVDGALIITPYYNKTTNKGLIKHFTAINNEVNIPIILYNVPSRTGVNITPNQLLELSRLNNVVAIKEASGNISQVIKMKSLCKDNIDIYSGNDDQIIPILSVGGLGVISVLANIIPNTVHNMTHSYLNGDVKKALELQLDSLDLCNSLFIETNPVPIKTALNLIGMDVGQLRLPLCEMDSSNEETLKKSLKFYNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJK1</accession>
    <name>A0A386PJK1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35381">
        <property type="protein sequence ID" value="AYE35381"/>
        <property type="gene ID" value="CP523_13605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="457" mass="50353" checksum="D8E20D333CE0EB35" modified="2018-12-05" version="1">MNKIKGFFNDKKFFKTLFILALPIIMQNILTSSLNMADTLMIGSIGDSQVAAVGIGNQFSFLFNLIVIGTTGGCSIFISQYWGKKDKKNIKKVVGIGGVTVIMVAIISMILALFVPELIVVIFTKDHEVIREASSYLAIVSLSYIVTAITFTIATSLRCMEDAKTPMIISAVAVGVNIVLNYIFIFGKLGFPAMGVKGAAIATVIARIIECILLMIKGHKHKVLHGDFKEYFQFNTEFVFLIYKSVIPVVLNEACWGLGTFFYSIAYGKLGTESMASVQITNNIQNLFFVVCFSMASSSLVMIGNQIGAGEEEIAKRYGRKFTILAFAMGVILGIIVFLLASPILKLFNVSDIVKEYSIIILKIYSICYPIRVVNLILIVGVFRGGGDAGFALKAEALTMWFIGVPMAFIGALILKFPIYLVILMVTAEEVAKFIVSIFRFKSYKWIHNVIEEESIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL7</accession>
    <name>A0A386PJL7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">CP523_08095</name>
        <name evidence="9" type="ORF">EI377_02850</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675959.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00733"/>
    <dbReference type="EnsemblBacteria" id="AYE34389">
        <property type="protein sequence ID" value="AYE34389"/>
        <property type="gene ID" value="CP523_08095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59794">
        <property type="protein sequence ID" value="QAS59794"/>
        <property type="gene ID" value="EI377_02850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08095"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="28716" checksum="DE303BADD0AAEB21" modified="2018-12-05" version="1">MEKRNMPIGFFDSGVGGLSVMREALKIMPNEDYIYFGDSKNAPYGTKSVKEVRDLTFKAVEFLLSKGAKGIVVACNTATSAAVAELRKVYPELPLVGIEPAIKPAVELKKEGSILIMATPMTLREKKFNLLMDKYREKANIVPVPCAGLMEFIERGILDGEELEIYLTEKLNEYRIPKISSIVLGCTHYPFISKTLSKIVGDDITIIDGGLGTAKEIRRRLEEKRLLTDSKEKGKIQIFNSLECDDAINLSKHLIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN4</accession>
    <name>A0A386PJN4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pseC</name>
        <name evidence="4" type="ORF">CP523_10895</name>
        <name evidence="5" type="ORF">EI377_05690</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.92" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677637.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02513"/>
    <dbReference type="EnsemblBacteria" id="AYE34872">
        <property type="protein sequence ID" value="AYE34872"/>
        <property type="gene ID" value="CP523_10895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60267">
        <property type="protein sequence ID" value="QAS60267"/>
        <property type="gene ID" value="EI377_05690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020026">
        <property type="entry name" value="PseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03588">
        <property type="entry name" value="PseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="396" mass="44615" checksum="89716AAA92D2A091" modified="2018-12-05" version="1">MDALAINGGKPVRDSYISYGKQTIDDKDIDMVIKVLKGDYLTTGPTVSEFEKKVANYVGAKYAVAVSNGTAALHMACYAAGIKSGDEVLVPAITFAASANCVLYCGGKPVFIDIDEKTYNMDIDKIEEKITSKTKAIIPVDFTGQSVDMDRILEIARKYNLVVIEDAAHALGSEYKGQKIGVKADMTEFSFHPVKPITTAEGGIIVTNDKNLYEKMLLFRTHGITRNEKFMNDNQGPWYYEQIDLGYNYRITDMQCALGISQMDKIDSFVKRRRDIVNKYNETFGNLKEVIIPYEAEYSNSGWHIYVIALNLNELTVGRKEVFEALQKENIGVNVHYLPVYMHPYYKSIGYKEGICPIAEDLYNKMITLPLFPSMTDKDVEDVITAVNKVIDFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS7</accession>
    <name>A0A386PJS7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14160</name>
        <name evidence="2" type="ORF">EI377_09065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678531.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35481">
        <property type="protein sequence ID" value="AYE35481"/>
        <property type="gene ID" value="CP523_14160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60867">
        <property type="protein sequence ID" value="QAS60867"/>
        <property type="gene ID" value="EI377_09065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="135" mass="15839" checksum="29E1C04F890727C9" modified="2018-12-05" version="1">MNVSPYYNYLLVMTDGSTKGFNDLETAKGYINIYYEDRIKKSSLKRDYHDITELPGQFRNNICQHMGVGEGECRVYDLDDFIEKLREQLVFDDEKEEIISKLLQKDISLNIYDYSLDNILTDVKVINMIEPYGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJT8</accession>
    <name>A0A386PJT8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">CP523_08520</name>
        <name evidence="5" type="ORF">EI377_03270</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674861.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01645"/>
    <dbReference type="EnsemblBacteria" id="AYE34469">
        <property type="protein sequence ID" value="AYE34469"/>
        <property type="gene ID" value="CP523_08520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59872">
        <property type="protein sequence ID" value="QAS59872"/>
        <property type="gene ID" value="EI377_03270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="191" mass="21574" checksum="C4F61BB698274CB8" modified="2018-12-05" version="1">MFLIVGLGNPGKEYDKTRHNIGFECIDYLSNKYNIELNRIKFKGIYGEGFINNKKVILLKPTTFMNLSGESIREVVNFYKLNPEEVIVIYDDISLEVGRIRIREKGSAGGHNGIKSIIQNLSTDVFPRIKVGVGQPKGDLVSHVLGRFSKEEEEILKESVEASKKAIEIIVREDTKEAMNRLNGFKASKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX1</accession>
    <name>A0A386PJX1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CP523_12950</name>
        <name evidence="17" type="ORF">EI377_07830</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678212.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03022"/>
    <dbReference type="EnsemblBacteria" id="AYE35258">
        <property type="protein sequence ID" value="AYE35258"/>
        <property type="gene ID" value="CP523_12950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60653">
        <property type="protein sequence ID" value="QAS60653"/>
        <property type="gene ID" value="EI377_07830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12950"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE35258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS60653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="126" mass="14553" checksum="A5159E7AA6C72651" modified="2018-12-05" version="1">MILVFGGAYNGKIKWVKEKYKIEEVDIFYCNSSEIDLSKRVICGLHKFTYAAGKDSLDPLKILIDNKEILKDKIIICDEISSGIVPLKKEERVWRENTGRCLQFLSENSNKVYRIFCGLEMVLKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ5</accession>
    <name>A0A386PJZ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13115</name>
        <name evidence="2" type="ORF">EI377_07985</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677863.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35288">
        <property type="protein sequence ID" value="AYE35288"/>
        <property type="gene ID" value="CP523_13115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60682">
        <property type="protein sequence ID" value="QAS60682"/>
        <property type="gene ID" value="EI377_07985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="74" mass="8926" checksum="C494C223606FDF8E" modified="2018-12-05" version="1">MNEIIEIKKEYNYYLKRNSNAEIYFKNESIESCLKHLKLFNDIALRLSKLQTIYKDITGLEMTKDERINGFKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK06</accession>
    <name>A0A386PK06_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">CP523_09015</name>
        <name evidence="7" type="ORF">EI377_03760</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678361.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00243"/>
    <dbReference type="EnsemblBacteria" id="AYE34549">
        <property type="protein sequence ID" value="AYE34549"/>
        <property type="gene ID" value="CP523_09015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59949">
        <property type="protein sequence ID" value="QAS59949"/>
        <property type="gene ID" value="EI377_03760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="70" mass="8381" checksum="6A431FC861034B9E" modified="2018-12-05" version="1">MKARELKELRENNPQDLKVKLNDLKAELFNLRFQLATGQLENPMRIREVKKSIAQIKTILREEEIRAYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK57</accession>
    <name>A0A386PK57_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09315</name>
        <name evidence="7" type="ORF">EI377_04060</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678009.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34609">
        <property type="protein sequence ID" value="AYE34609"/>
        <property type="gene ID" value="CP523_09315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60009">
        <property type="protein sequence ID" value="QAS60009"/>
        <property type="gene ID" value="EI377_04060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="491" mass="53174" checksum="157794895C757246" modified="2018-12-05" version="1">MSNKRGILSSKALMLMTFTAVFSFGNIIDSSVNIGLATVPSYLFGTIFYFFPFALMIGEFASANEDSESGINSWIKTSLGSKWAFLGSWSYFFVNLFFFTSLLPKTLIYASYTFVGKNVFEGKTVLISIISIILFWGVTIISTKGVGWISKVTSLSGVARMILGIGFIVLSFGVIFVLGKAPAQEFNVQSMTPKFDWKYFMVLAWVLQAVGGAESIGVYIKDVKGGNKAFIRTMLFSTVLIGALYALGGVAVGIVVPSNILQGNFSNGLFDSFALLGSYYGIGNIITNIVGFIMLLASLGSLVLWTAAPVKVLFSEIPEGIFGKWVAKTDDQGNPINALYLQAIIVTILLIIPALGIGSVDSLLEILINMTASTSLIPVLFFLVGYIVLRAKKEYVVERSFKIGSRKLGIAIGVLLLGLFSFVFVISSIPTPSDIMAYLNGTLAEGAANPIFVLLYNILGLIVFLGFALICWHRYENKVGKDVANGNLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK85</accession>
    <name>A0A386PK85_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Anti-sigma factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_09505</name>
        <name evidence="11" type="ORF">EI377_04250</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34639">
        <property type="protein sequence ID" value="AYE34639"/>
        <property type="gene ID" value="CP523_09505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60038">
        <property type="protein sequence ID" value="QAS60038"/>
        <property type="gene ID" value="EI377_04250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024449">
        <property type="entry name" value="Anti-sigma_RsgI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12791">
        <property type="entry name" value="RsgI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51849">
        <property type="entry name" value="RSGI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RsgI N-terminal anti-sigma" evidence="9">
        <location>
            <begin position="153"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="40237" checksum="9F10154BBF8CC8D8" modified="2018-12-05" version="1">MSDFEKDKYKFSSKTPLSIVKEGDYEKHREEIVLLAEELNNYKILFKDLTTDEPQYSTRNLILNIAYFILGEFEIYDYLIEKNELPIGKLIKRMPIARGFLETWRDYIITYVTILANPKYGYIQDYLKIEENVSILGVNEINEEKQLKKIKEFSGIVVLNKFNSCIILTSKGEFKNIKVKESHEIGMEVHGEIKKGIKHYKLHISILILLLIFMVGLIVHKYKSVNNTVIIETTSSVKLEVNYFNRIIKAYSPTTKGEEMLSSLDILDNDVDDGLCKILNYAFQNDMIPNDGVTVVITGKPVEYGTLHETEAFINESGIYVKYNNSGNQHNFNPKPKTIEGDTKDEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKB9</accession>
    <name>A0A386PKB9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline trimethylamine-lyase activating enzyme</fullName>
            <ecNumber evidence="9">1.97.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Choline utilization protein D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">GRE activase CutD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycyl-radical enzyme activating enzyme CutD</fullName>
            <shortName evidence="9">GRE activating enzyme CutD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">cutD</name>
        <name evidence="12" type="ORF">CP523_12435</name>
        <name evidence="13" type="ORF">EI377_07320</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes activation of the choline trimethylamine-lyase CutC under anaerobic conditions by generation of an organic free radical on a glycine residue, via an homolytic cleavage of S-adenosyl-L-methionine (SAM).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine metabolism; choline degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675333.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02026"/>
    <dbReference type="EnsemblBacteria" id="AYE35162">
        <property type="protein sequence ID" value="AYE35162"/>
        <property type="gene ID" value="CP523_12435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60565">
        <property type="protein sequence ID" value="QAS60565"/>
        <property type="gene ID" value="EI377_07320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12435"/>
    <dbReference type="UniPathway" id="UPA01069"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042426">
        <property type="term" value="P:choline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02059">
        <property type="entry name" value="Activ_enz_CutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030905">
        <property type="entry name" value="CutC_activ_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04395">
        <property type="entry name" value="cutC_activ_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="9">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="9">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="35631" checksum="CC27B6F26B9183AA" modified="2018-12-05" version="1">MSNGNLGIIQRKATIFNIQKYNMYDGDGIRTLIFFQGCPLRCKWCANPEGMIRKYRVMLKSNLCINCGECVSVCPVGIHTISNETLKHEVNHNIDCIGCGKCKDACLKSALSIVGEEKTISELLEIIEEDRTFYEMSGGGVTLGGGEVLMQPEAASSLLMACKQEGINTAIETCGYAKLESVLKVAEFTDLFLFDIKHIDSDKHFELTGVRNEQILENLKALLNGKYNVQIRMPLLKGINDSQEAIEGAMEFLKPYKDYKNFRGVDLLPYHKMGVNKYNQLGIEYPIKGDPSLNSEDLDRIEGWVKKYDLPVKVIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKD5</accession>
    <name>A0A386PKD5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12095</name>
        <name evidence="6" type="ORF">EI377_06925</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673507.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02976"/>
    <dbReference type="EnsemblBacteria" id="AYE35096">
        <property type="protein sequence ID" value="AYE35096"/>
        <property type="gene ID" value="CP523_12095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60489">
        <property type="protein sequence ID" value="QAS60489"/>
        <property type="gene ID" value="EI377_06925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
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    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
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    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
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        <location>
            <begin position="130"/>
            <end position="149"/>
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    </feature>
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        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="222"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="369"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="567" mass="65694" checksum="4A62D424C45F953B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKF0</accession>
    <name>A0A386PKF0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">celB</name>
        <name evidence="11" type="ORF">CP523_12250</name>
        <name evidence="12" type="ORF">EI377_07075</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673592.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03005"/>
    <dbReference type="EnsemblBacteria" id="AYE35126">
        <property type="protein sequence ID" value="AYE35126"/>
        <property type="gene ID" value="CP523_12250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60518">
        <property type="protein sequence ID" value="QAS60518"/>
        <property type="gene ID" value="EI377_07075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00359">
        <property type="entry name" value="cello_pts_IIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="8"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="445" mass="48301" checksum="F360CC2DD318402F" modified="2018-12-05" version="1">MDKLVSIIEKVLMPIAEKVSDQKHLSAMKDGLLLVMPLTIVGSLFLVLASLPIPGYSEFIASIFGELWSEKLGYVVGVTMDLMGVITVIGTSYRLAKIYKVEALSASIIALVSFFLVTPYKINFLQEGAVDPIIVKGIPLALMGSRGLFVAIIVALVSTEIYRKVVQKGIVIKMPKGVPVAVSQSFADLIPATICLTFFWLVRVLLELTSFGDIHNLVTTVISTPLQGLGNSLFGAIIYALLVGLFWCFGIHGGAIMNGILGPVLMTLNDANRLAFESGQPVANTVTNTFFDIFIFAGGAGATLVFTLLMLYRARSKQLKSLGKLSIGSGLFNINEPVMFGTPIVLNPILMIPFVLAPVVMVIISYFAMQTGLVERAVGITVPWTTPIFISGYLATGGKISGVILQLVNFIVSMLIYYPFFRIWDNQKVKEESEIAIESDNTINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKF6</accession>
    <name>A0A386PKF6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_15690</name>
        <name evidence="6" type="ORF">EI377_10410</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE35761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00553"/>
    <dbReference type="EnsemblBacteria" id="AYE35761">
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        <property type="gene ID" value="CP523_15690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61100">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="236" mass="26866" checksum="9CAAA64B1E6B2C69" modified="2018-12-05" version="1">MELSLENIKKNYGNKEVLKGASFIFKKGKIYGLLGRNGAGKTTLFNCISGEIKCDNGKIILSEDGDSTEILDYSKVGYVFSEPVLPEFLTGYEFLKFYIDINKNKIDNILTIEEYFDIIKINKEDRYRLIKGYSHGMKNKIQMLCFLISRPPVILLDEPLTSFDVVVALEIKNLLKRIKSNHIIIFSTHILQLATDLCDEIVVLNNGVLEGVDNKILNSSDFEEKIINILKEETND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKH5</accession>
    <name>A0A386PKH5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ComF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10295</name>
        <name evidence="3" type="ORF">EI377_05075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674293.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01436"/>
    <dbReference type="EnsemblBacteria" id="AYE34759">
        <property type="protein sequence ID" value="AYE34759"/>
        <property type="gene ID" value="CP523_10295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60159">
        <property type="protein sequence ID" value="QAS60159"/>
        <property type="gene ID" value="EI377_05075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10295"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="24501" checksum="67E9CCBFD7CCFB6F" modified="2018-12-05" version="1">MGKRIIKILKPILDSVLDIIYPEKSNCINCYADDYIGLCPKCINSIKRIKTEEKIKPFAYYNGAIKKLILELKYKNNFLAAKILGEFISALIKENNIEADVILYVPLSKRSYKKRGYNQSKLIANIVSEKCNIEISNSLIKVKNTKEQKTLSKDERMSNLIDAFDIKDYNEVKNKRVILIDDVVTTGATLLECEKILKKFNASTINILTVAKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKN9</accession>
    <name>A0A386PKN9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Com family DNA-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35871">
        <property type="protein sequence ID" value="AYE35871"/>
        <property type="gene ID" value="CP523_13265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019294">
        <property type="entry name" value="Translation_reg_Com"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10122">
        <property type="entry name" value="Mu-like_Com"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="48" mass="5642" checksum="CCC9E0859F058855" modified="2018-12-05" version="1">MNEVINIEDVRCFCCNQLLIKADYVKGEIKCPRCKKIIKIEVKEKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKV3</accession>
    <name>A0A386PKV3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13905</name>
        <name evidence="2" type="ORF">EI377_08800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678798.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00148"/>
    <dbReference type="EnsemblBacteria" id="AYE35432">
        <property type="protein sequence ID" value="AYE35432"/>
        <property type="gene ID" value="CP523_13905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60820">
        <property type="protein sequence ID" value="QAS60820"/>
        <property type="gene ID" value="EI377_08800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="369" mass="42402" checksum="50C88EF8BBD0E014" modified="2018-12-05" version="1">MKKFKRIIILVITLLVIGGISAFIYFEKGKRSIQVVEWDNVYNEKNIAYNFSEVDNPKIKELDNIYKIKESTKNEDTPLKKVLKVVELVNSVVSFDDVPNSKGINAYDILKEKKDAKKVSARDMAIITRDFISCLDLDVRVGEFRNPKGNINKQKNYYVVEYWSKVDNKWIMIDFKDHGYFENQGFLCSATELLEDDTKILKYNGNSTKKDYMDNLNKSLGSYTVAIDNSVDMKKSNSYVTYIKDKENITLDFKGGYILPTIYTEELELINKNPIDNVIGKDQKAYIILMKKQEAEGNNKDKEEKSKSLIIGGFRNGSIIDSYYIKENSGEYKEVKRYSDVVLKPGENIIELSLDGKNVASKIVIECNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLB0</accession>
    <name>A0A386PLB0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">recX</name>
        <name evidence="6" type="ORF">CP523_14400</name>
        <name evidence="7" type="ORF">EI377_09365</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676807.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02471"/>
    <dbReference type="EnsemblBacteria" id="AYE35526">
        <property type="protein sequence ID" value="AYE35526"/>
        <property type="gene ID" value="CP523_14400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60912">
        <property type="protein sequence ID" value="QAS60912"/>
        <property type="gene ID" value="EI377_09365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="212" mass="25244" checksum="9D9AA1736B4E2CF5" modified="2018-12-05" version="1">MNVITKIEVQKRNKDRVNIYINEEYAFSLSSELVYKEGLKLKQTIDIDKIKKVAKEDSYIKCKEAALRIVEKTYKTQKEIKDKLFLKGYDENTIDRTIEFLEEYNFIDDKNYTRMYVSDKIKKQGANKIKYELTKKGVSEELIKDQISNIDKDSEKEVAYLLAEKKYSILKKREGDKYKLSQKLYRFLISKGYEYDIVSEIVKKIVNNEEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLH5</accession>
    <name>A0A386PLH5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13070</name>
        <name evidence="2" type="ORF">EI377_07940</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677837.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35279">
        <property type="protein sequence ID" value="AYE35279"/>
        <property type="gene ID" value="CP523_13070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60673">
        <property type="protein sequence ID" value="QAS60673"/>
        <property type="gene ID" value="EI377_07940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="84" mass="10214" checksum="16D75D9CB46909B7" modified="2018-12-05" version="1">MLEFDDYGRIKYNPKFHAKSGTPWSYEDEKYLIDWYEIIGIEELSFALERPEANISSKIYKLKREGKIKRNRKGKFNKRLIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLI3</accession>
    <name>A0A386PLI3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mobB</name>
        <name evidence="2" type="ORF">CP523_15635</name>
        <name evidence="3" type="ORF">EI377_10350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678620.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00564"/>
    <dbReference type="EnsemblBacteria" id="AYE35752">
        <property type="protein sequence ID" value="AYE35752"/>
        <property type="gene ID" value="CP523_15635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61089">
        <property type="protein sequence ID" value="QAS61089"/>
        <property type="gene ID" value="EI377_10350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="18815" checksum="C8347699D04641B7" modified="2018-12-05" version="1">MCKIINIIGTGSNVGKTVLIEGLIKELSGRGYSVSTIKHDVHGFDIDKKGKDTYRHRKAGAETVIISSKNRLAMIKEVNNEVSLDEIINMVLDKDFVLVEGYKNSNLRKIEVFRKGLSKEIITPKENLIAIASNENINYFDVPVIDKEDYKALADLVENEKEYSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLL0</accession>
    <name>A0A386PLL0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl_transf_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677527.1">
        <property type="nucleotide sequence ID" value="NZ_CP023671.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35339">
        <property type="protein sequence ID" value="AYE35339"/>
        <property type="gene ID" value="CP523_13385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="11"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="342" mass="40394" checksum="FE3C6570398094CC" modified="2018-12-05" version="1">MNKLTNRNYLLDNLKVLLMFCVVFGHVIEYYINQSNILKGIYIFIYIFHMPLFIFISGYFSKNVEKISKGAIKGLLLPYLIFDMIWYMVVYIGTGEFMFSVLYPGWTLWYLLSLFFWRISLKYLIKIKYILPISFICGLLIGMLPSGSSVLAISRTITFLPFFLLGYYTKEKDFMEIQKSNKLISVIVIILFAYGAFYISKNNLIDYRFLYNSSTYYESGLTVFQGMFFRVLLYIGAIIFSICTINLTPKVKVIYSYIGKATMNIYVFHIYLVLLVYFFIPKWNLDYIRNTLLLLSPFLIIYILAKKPVTKVYDSIFYPVNKGIHHGRKSFKKCKDFKYKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLQ2</accession>
    <name>A0A386PLQ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13815</name>
        <name evidence="3" type="ORF">EI377_08710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677133.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02059"/>
    <dbReference type="EnsemblBacteria" id="AYE35419">
        <property type="protein sequence ID" value="AYE35419"/>
        <property type="gene ID" value="CP523_13815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60807">
        <property type="protein sequence ID" value="QAS60807"/>
        <property type="gene ID" value="EI377_08710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="216"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="306" mass="35233" checksum="B21B5E50A64A6C7D" modified="2018-12-05" version="1">MRYFVIDFETANSKRTSSCALGIVEVISGKIINSWDYLINPEEKFDNFNIYIHGITEDMVKDKPTFPELWPKIKEILENNIIIAHNASFDISVLRHTLDKYNLEYPSFKYSCTRILSKKTWPSLINYKLDTLANMLNIQFIHHKACEDAIATAKIFERILLVNSINEFDDLHETLKIKPGLVYPNSYTPCEVKHSSYSIRQYIKPKDILPENENFDTNHVLYNKGISFTGALTSMSRKDAAQCAVNKGAFFCNTVTKKTNYLVIGIQDYTRFSDGEKSSKLKKAEDLIKLGQDLEIIDENEFLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM91</accession>
    <name>A0A386PM91_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35779">
        <property type="protein sequence ID" value="AYE35779"/>
        <property type="gene ID" value="CP523_15780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="76" mass="8963" checksum="E1DB4435AB95C3AA" modified="2018-12-05" version="1">MKGFTNKTSYIFTILIFILAIYNISITLIDFGMISFGRQFFLIVIFLFLFIPYFKNNKKKNEIIKSGLLLEQKVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAP4</accession>
    <name>A0A386PAP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxyglutaryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_00225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01187"/>
    <dbReference type="EnsemblBacteria" id="AYE32985">
        <property type="protein sequence ID" value="AYE32985"/>
        <property type="gene ID" value="CP523_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="326"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="5">
        <location>
            <begin position="676"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1410" mass="158456" checksum="F9A36CE8A722B70A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB77</accession>
    <name>A0A386PB77_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">accB</name>
        <name evidence="4" type="ORF">CP523_01235</name>
        <name evidence="5" type="ORF">EI377_11735</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674363.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02271"/>
    <dbReference type="EnsemblBacteria" id="AYE33175">
        <property type="protein sequence ID" value="AYE33175"/>
        <property type="gene ID" value="CP523_01235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61345">
        <property type="protein sequence ID" value="QAS61345"/>
        <property type="gene ID" value="EI377_11735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01235"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18891" checksum="CA5A6E168BEDF775" modified="2018-12-05" version="1">MDFKEIRELIEMINSSELAYFELKMGDNYIKMDKSLTRSTPEKSSRSNELNVEEIKEKVYKENTENSFKSEDTIVEESKENEDLDITTITCPMVGTFYASPAPGQDSFVKEGMKVSKGNILCIVEAMKLMNEIECEYDCEIYKILVKDGDMVEYGQPLFSVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBS1</accession>
    <name>A0A386PBS1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_01360</name>
        <name evidence="12" type="ORF">EI377_11870</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19621"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66949"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="EC" id="3.1.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00823"/>
    <dbReference type="EnsemblBacteria" id="AYE33200">
        <property type="protein sequence ID" value="AYE33200"/>
        <property type="gene ID" value="CP523_01360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61372">
        <property type="protein sequence ID" value="QAS61372"/>
        <property type="gene ID" value="EI377_11870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07410">
        <property type="entry name" value="MPP_CpdB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041827">
        <property type="entry name" value="CpdB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034113965" evidence="8">
        <location>
            <begin position="31"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="9">
        <location>
            <begin position="43"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="10">
        <location>
            <begin position="391"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="665" mass="74600" checksum="776B5CF520F6F8EE" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBV7</accession>
    <name>A0A386PBV7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02580</name>
        <name evidence="2" type="ORF">EI377_13115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673921.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00451"/>
    <dbReference type="EnsemblBacteria" id="AYE33425">
        <property type="protein sequence ID" value="AYE33425"/>
        <property type="gene ID" value="CP523_02580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61599">
        <property type="protein sequence ID" value="QAS61599"/>
        <property type="gene ID" value="EI377_13115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013367">
        <property type="entry name" value="Flagellar_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12611">
        <property type="entry name" value="Flagellar_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02530">
        <property type="entry name" value="flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="128" mass="14466" checksum="6C500BB359C99B58" modified="2018-12-05" version="1">MGFRIVNGSLYPVDNLQAPIQNDKNRELNSKNSTFKNILDKTIGNSFTYTLSKHAVERLKYIDFSNKDMKAIEKGFQMAEKKGAKNCVMIYKDTALIASVQNKTVITAVEKERAKENVFTNIDSVVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBX8</accession>
    <name>A0A386PBX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS fructose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_00565</name>
        <name evidence="16" type="ORF">EI377_11055</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676339.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00643"/>
    <dbReference type="EnsemblBacteria" id="AYE33047">
        <property type="protein sequence ID" value="AYE33047"/>
        <property type="gene ID" value="CP523_00565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61216">
        <property type="protein sequence ID" value="QAS61216"/>
        <property type="gene ID" value="EI377_11055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="12">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="13">
        <location>
            <begin position="170"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="14">
        <location>
            <begin position="289"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="621" mass="65437" checksum="4B4F9510B88E05C5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC14</accession>
    <name>A0A386PC14_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metal ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02885</name>
        <name evidence="9" type="ORF">EI377_13410</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677008.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00983"/>
    <dbReference type="EnsemblBacteria" id="AYE33483">
        <property type="protein sequence ID" value="AYE33483"/>
        <property type="gene ID" value="CP523_02885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61654">
        <property type="protein sequence ID" value="QAS61654"/>
        <property type="gene ID" value="EI377_13410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="263" mass="28751" checksum="333AECB51617526B" modified="2018-12-05" version="1">MFQLGFMQNAFMASFIIAILCPFIGLFLVLRRYSMIGDTLSHSSFAGVAIGLVIGVNPLISAFLFTTFCALIIEFLRDYYKKYAELVMSLVLTFSLGIAIILISSGKASTNVNSYLFGSILTVSTSDIVMISIIGIICLITLIVLYNKLVYITFDEEGAKTCGIKVKLINYIFTLLVGATISMSIRIMGILVISSIMVVPVATSMQLKKSFKSTLIYSIIFGFLDIMLGLILSYYMNSAPGGTIAITSVLTLICVILFQKITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC92</accession>
    <name>A0A386PC92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4003 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02385</name>
        <name evidence="2" type="ORF">EI377_12905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673975.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33390">
        <property type="protein sequence ID" value="AYE33390"/>
        <property type="gene ID" value="CP523_02385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61562">
        <property type="protein sequence ID" value="QAS61562"/>
        <property type="gene ID" value="EI377_12905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025062">
        <property type="entry name" value="DUF4003"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13170">
        <property type="entry name" value="DUF4003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="316" mass="36624" checksum="00730B5C3D7B0159" modified="2018-12-05" version="1">MEKILQDRIQLTIKNYREAKDSLRNDGDLLNHFASLVYAHYEKEIPVERVKEIRKYIKATSSRVSPFRGDILYMLSLLIALEEGKEKELVNNIYDIMNLLIEEGFKECDHLVLASFVVAKYGRNKDKYEIIRKIKDVYIILKEKYYNITQEDDYLVCALWALNDIDVQTIDEFIEVVYDQMSSLQIKSKNGIQGLGNAIILNGSSGDMYRTIEFILQLEKRDLKIAQQFLPVLGVVSNLTPRKNVEIVEGVIDSLCEEEAEYEYYMDKGFRTIIAISIVAFCMVSEKRRYMDELLAHGVYCFIQSKNKGIFAEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCE7</accession>
    <name>A0A386PCE7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">flgK</name>
        <name evidence="9" type="ORF">CP523_02705</name>
        <name evidence="10" type="ORF">EI377_13230</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676952.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00947"/>
    <dbReference type="EnsemblBacteria" id="AYE33450">
        <property type="protein sequence ID" value="AYE33450"/>
        <property type="gene ID" value="CP523_02705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61621">
        <property type="protein sequence ID" value="QAS61621"/>
        <property type="gene ID" value="EI377_13230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="561"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="611" mass="68068" checksum="3AEB86C4EB914CE0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCH0</accession>
    <name>A0A386PCH0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="6">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabG</name>
        <name evidence="7" type="ORF">CP523_01245</name>
        <name evidence="8" type="ORF">EI377_11745</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02269"/>
    <dbReference type="EnsemblBacteria" id="AYE33177">
        <property type="protein sequence ID" value="AYE33177"/>
        <property type="gene ID" value="CP523_01245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61347">
        <property type="protein sequence ID" value="QAS61347"/>
        <property type="gene ID" value="EI377_11745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01245"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0753">Steroid metabolism</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="246" mass="26168" checksum="03E3388F4215BB0C" modified="2018-12-05" version="1">MLKNKCAVVTGATRGIGRAIAKKYASLGANIVINYRNSDSEAKILEEELKGLGVEVLVIKADISNFNEAQNLINSAKERFGSVDILVNNAGITKDGLVMRMKEEDFDSVIQVNLKGVFNCLRAVSPIMIRQKSGKIINMSSVVGIVGNAGQINYCAAKAGVIGMTKSLAKELGGRGINVNAIAPGFIKTDMTNKLSDKNKEIIMENIPLKRIGVVEDIAEVAAFLASEAASYITGQVISVDGGMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCR1</accession>
    <name>A0A386PCR1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01715</name>
        <name evidence="3" type="ORF">EI377_12235</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677347.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33267">
        <property type="protein sequence ID" value="AYE33267"/>
        <property type="gene ID" value="CP523_01715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61438">
        <property type="protein sequence ID" value="QAS61438"/>
        <property type="gene ID" value="EI377_12235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="200" mass="23695" checksum="CC38BC6DF2F447A4" modified="2018-12-05" version="1">MKVLKYFIFPFFISLILLFFYNYSPIKTDIIYTKEITPHNYTSNAKLTEISKLKLIDKSEELLTTLFSNEFKISDYVPEVSFYKISNNNIADISFREKENPSLNYMVSFNIQTSYPYHIDYYNFKDIDYEDTQILSSDELKSSALDYFSKIPINNKDSVKFSHFYINDTYTAYFKDYSSETVISITLNKFTGKLISYYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCR9</accession>
    <name>A0A386PCR9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF975 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF975 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03415</name>
        <name evidence="3" type="ORF">EI377_13940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677886.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33580">
        <property type="protein sequence ID" value="AYE33580"/>
        <property type="gene ID" value="CP523_03415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61744">
        <property type="protein sequence ID" value="QAS61744"/>
        <property type="gene ID" value="EI377_13940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010380">
        <property type="entry name" value="DUF975"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40076">
        <property type="entry name" value="PTHR40076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06161">
        <property type="entry name" value="DUF975"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="200" mass="22621" checksum="92F343CF94ADAB4B" modified="2018-12-05" version="1">MIIRRELKSNSKDQLRGNWGLAIITILVYSLIISIFGYSDSIYNNNIEIILDLSSLLLSGVLTLGISKFLLNLTKKDSSAKFTDLFSGFNVYFKTLGLNILLGIIIGIGTIFLVVPGLIFALMFSQTFFILSEDNEKGIIQCLSESREMMIGYKFDYFVLMLSFLGWWLVSALTLGIGALWVYPYQKLTEANFYLEIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCV0</accession>
    <name>A0A386PCV0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04610</name>
        <name evidence="3" type="ORF">EI377_15165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675827.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33803">
        <property type="protein sequence ID" value="AYE33803"/>
        <property type="gene ID" value="CP523_04610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61960">
        <property type="protein sequence ID" value="QAS61960"/>
        <property type="gene ID" value="EI377_15165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="26130" checksum="C0EBE63FA17006BF" modified="2018-12-05" version="1">MSTLTLAFIFYVFYLVTKLLLSFYVYKDAEDLQLNSKIWSTITMLFPNYIGFVFYLIIKTVKINKELNEKNSNISIKKFKKPILLITSILFLGTSYYFLGDYFSSTFSSKFNNYNEATILMENGWISSEIPNTATNIYEVHDLDTNIGNGVFNLSEKEAKEFFETLNPIEKNEVLKMKSIRKRWWNKKEIEKNIKNDKYLLGEKGNFLYAIDPNGNVYFWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD58</accession>
    <name>A0A386PD58_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04200</name>
        <name evidence="4" type="ORF">EI377_14725</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00436"/>
    <dbReference type="EnsemblBacteria" id="AYE33730">
        <property type="protein sequence ID" value="AYE33730"/>
        <property type="gene ID" value="CP523_04200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61887">
        <property type="protein sequence ID" value="QAS61887"/>
        <property type="gene ID" value="EI377_14725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="16584" checksum="AB3CE23A7E13CBCA" modified="2018-12-05" version="1">MESINGDAQYYGYRKITYHLRRTYNLIINCKKVYRLCKELNILIWQRKIHFKTKRILASNRTVTASNQVWEIDIKYGYVHGEINEFQTYAEAYKIVNTFMSFYNERRLHSSLKYMPPREFYTLYFGEHVEKICIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDH3</accession>
    <name>A0A386PDH3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02290</name>
        <name evidence="4" type="ORF">EI377_12810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674010.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33374">
        <property type="protein sequence ID" value="AYE33374"/>
        <property type="gene ID" value="CP523_02290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61544">
        <property type="protein sequence ID" value="QAS61544"/>
        <property type="gene ID" value="EI377_12810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="10131" checksum="2830CBAB21F9C34A" modified="2018-12-05" version="1">MIKADFRDVKIKGKVMRNKGYSTGTLKRKNGDIIPISMVGHKLDTYIARHGLNSKITIELDGLKINSKIDRVQRDLIFHNAINIDLIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDR7</accession>
    <name>A0A386PDR7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06540</name>
        <name evidence="8" type="ORF">EI377_01025</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02185"/>
    <dbReference type="EnsemblBacteria" id="AYE34155">
        <property type="protein sequence ID" value="AYE34155"/>
        <property type="gene ID" value="CP523_06540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59523">
        <property type="protein sequence ID" value="QAS59523"/>
        <property type="gene ID" value="EI377_01025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
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            <end position="397"/>
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            <end position="460"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50903"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34155.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59523.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="880" mass="97331" checksum="D7E80D833032C35B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDT7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE33008">
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        <property type="gene ID" value="CP523_00360"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="40"/>
        </location>
    </feature>
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            <end position="574"/>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122709" checksum="3EF7FBE8465C852B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDY9</accession>
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        <submittedName>
            <fullName evidence="2">50S ribosomal protein L7ae-like protein</fullName>
        </submittedName>
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        <lineage>
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                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        </source>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="12097" checksum="3DC1F10606C0A352" modified="2018-12-05" version="1">MNKFFNFLGLAKRSGNLIEGYSKCNEQRNRIKIYLFIISKDASESTRKKFLNHCNINNILYIEDFSKEELGISIGREEVKILAISDENMAKKLNTLYEEGKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="4" key="1">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="QAS61442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE33271">
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        <property type="gene ID" value="CP523_01740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61442">
        <property type="protein sequence ID" value="QAS61442"/>
        <property type="gene ID" value="EI377_12260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="16264" checksum="95BADD972F86780D" modified="2018-12-05" version="1">MFLKDRNIKEEILDLVKLTKENKEKYLKVFNDSFSDMPHGRFCDLSDIEGYINKSNDKKYFFMVAEYTDIIGFMNCEIKKERGIFDIGLCKKYRGKGYGKKLLETAIEFLNKLVTSIFFIYKGYRGIYYKLFRVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE66</accession>
    <name>A0A386PE66_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03205</name>
        <name evidence="6" type="ORF">EI377_13720</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677254.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02142"/>
    <dbReference type="EnsemblBacteria" id="AYE33544">
        <property type="protein sequence ID" value="AYE33544"/>
        <property type="gene ID" value="CP523_03205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61707">
        <property type="protein sequence ID" value="QAS61707"/>
        <property type="gene ID" value="EI377_13720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03205"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="25537" checksum="356FEE66726CDE08" modified="2018-12-05" version="1">MSKNIKKDISNIEKDYIYLSLKSDSLRIGIIGGGKAALIKARSFLKKGCFVEIISKNFNEELLSNRSDCLKLNQGSYSKEFIEDKHIVVIAVDDYELVEKIIVHCDESSKIYVNATDFKNGKAIIPVQRESKNLNFAVSTKLGNPKGALLVANKALSILEEYDEFIEYSSKVRNNAKYIEEYKKEIIDFVCTEDFKFIYNIKKHKEVLTMFFNEDIINKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA0</accession>
    <name>A0A386PEA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartyl-tRNA amidotransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">GatB/YqeY domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02225</name>
        <name evidence="2" type="ORF">EI377_12745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674030.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00522"/>
    <dbReference type="EnsemblBacteria" id="AYE33361">
        <property type="protein sequence ID" value="AYE33361"/>
        <property type="gene ID" value="CP523_02225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61531">
        <property type="protein sequence ID" value="QAS61531"/>
        <property type="gene ID" value="EI377_12745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="16949" checksum="615DC162EBE0321D" modified="2018-12-05" version="1">MPIKDRLQEDWKTALKSKDKFRANVISTAKSAILLVEKTDGVKLEDDKVIEILAKEVKQRREAMLEFEKGNRQDLVDQNKAEIEILLNYLPQQLNEQEILEIIKVSATEVGANNIKDMGKVMAVVRPKVMGRADGKLVSQIVKDYLTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA5</accession>
    <name>A0A386PEA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676411.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00376"/>
    <dbReference type="EnsemblBacteria" id="AYE33787">
        <property type="protein sequence ID" value="AYE33787"/>
        <property type="gene ID" value="CP523_04510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="407" mass="46465" checksum="0AB79B567F958E12" modified="2018-12-05" version="1">MIKYSYFYIKKSFFISVLLIFQLIFLILSLYNSFDIFTGFNIEKKQISKFFSDEILYGIEFRSDLNSSTSNDAFSNAEKIINDYLNTNSNHDFFLTLNSIESLSLEKFDNYENFKFPNSPEEGNKFYAKSLHINSDSLKRFPINLYEGRTFNDTELTHISSPKDTIPIILGYDFLNIYNIGDIITIGSSHNAEVIGILSKDQFNPGNLQSSQRFANLNNYIIIPNNYLDSGAYLTGAALLIFDKSTSKEYLNNIRSDLRNLFNEIDVSIDVRDFSSDLSIKITQYLNGLKDIVMISVIITIFIFVSITITLLNSILLYKKDFGVHYLTGARTIDIIKIISGELFILSFVAIILSTPIFIFKGLTNKINVIALLSTFIFLLIMNLIILIIPIVNINKIQLNQLIKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEG6</accession>
    <name>A0A386PEG6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04840</name>
        <name evidence="3" type="ORF">EI377_15350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675769.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33847">
        <property type="protein sequence ID" value="AYE33847"/>
        <property type="gene ID" value="CP523_04840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61993">
        <property type="protein sequence ID" value="QAS61993"/>
        <property type="gene ID" value="EI377_15350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="212" mass="24668" checksum="716E90A296AF0AD9" modified="2018-12-05" version="1">MTKINNKNKLLLLIISLILIFLALVNTTRLDYILIISAVVVLCIEFFCDFLLKTNTTCQLKSNEFFKTFLKLEKFSFGLFGIFIFSLIIVRLFPWIMLSIDINNSYFLPFEVIQIDYFPIIITIILTLITSIFPPIISINNYLSKTNKYIILLQNKLRISSVSTILLRISTITSLMFILLDYKLYSILVLIFSLLLSIYIITKISKTDKEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV5</accession>
    <name>A0A386PEV5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_09195</name>
        <name evidence="12" type="ORF">EI377_03940</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678339.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03059"/>
    <dbReference type="EnsemblBacteria" id="AYE34585">
        <property type="protein sequence ID" value="AYE34585"/>
        <property type="gene ID" value="CP523_09195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59985">
        <property type="protein sequence ID" value="QAS59985"/>
        <property type="gene ID" value="EI377_03940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26828" checksum="F2B5BB0A65AB0E2A" modified="2018-12-05" version="1">MFNVLVVDDEKEIRDAIDIYLRGEGMKVYKAKDGIEALEILDTEKIHLIVLDIMMPRLDGIKTCLKIRESKNLPIIMLSAKGEDSDKILGLNVGADDYVAKPFNHLELVARVKSQLRRYQKPLDMDEQSEDIIEVKDLVINSKEKTITLRGEDIKVTATEFKILYLLASNLGKVFSIKEIYEKVWEEPFYRSENTVTVHIRRIREKIEINTKEPEYIKVVWGVGYKIEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX4</accession>
    <name>A0A386PEX4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">CP523_09295</name>
        <name evidence="14" type="ORF">EI377_04040</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34605">
        <property type="protein sequence ID" value="AYE34605"/>
        <property type="gene ID" value="CP523_09295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60005">
        <property type="protein sequence ID" value="QAS60005"/>
        <property type="gene ID" value="EI377_04040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="257"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="373"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="447" mass="48258" checksum="A12110B55BB966C1" modified="2018-12-05" version="1">MGRMFGTDGVRGIANLELTADLAYSLGRAGAYVLTEGTHKPKILVGKDTRISGDMLEAALVAGILSVGAEAVILGVVPTPAVAHLTREYGADAGIMISASHNPVEYNGIKFFDNKGYKLPDELEDEIQRVIESGFEGVPSPVGHDLGKSTVEVGALDEYMDYAMSTIAVDLKGLKIALDCANGACYKAAVKSFRELGAEVYVINDNPDGTNINENCGSTHPEELMDYVVRKKCDLGFAFDGDADRCLAVDEKGNLINGDFILTLCAKYLKDLGQLKDDTLVVTVMSNLGLDIACKKEEINLIKTKVGDRYVLEEMIKDGYVLGGEQSGHIIFLNYNSTGDGLVTALQVSAIKKKSGKTLSELAGIMKELPQVLVNAKVPNDKKNIYLEDLEIIEAIKKIEETLNGVGRVLIRPSGTEPLVRVMLEGENQEEIDKMAHSLADLILSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ7</accession>
    <name>A0A386PEZ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INTEIN_C_TER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34007">
        <property type="protein sequence ID" value="AYE34007"/>
        <property type="gene ID" value="CP523_05765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="SSF51294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="INTEIN_C_TER" evidence="2">
        <location>
            <begin position="1677"/>
            <end position="1701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1825" mass="206296" checksum="8B1C7BD92F8407EC" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF50</accession>
    <name>A0A386PF50_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09750</name>
        <name evidence="10" type="ORF">EI377_04550</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676751.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02656"/>
    <dbReference type="EnsemblBacteria" id="AYE34685">
        <property type="protein sequence ID" value="AYE34685"/>
        <property type="gene ID" value="CP523_09750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60086">
        <property type="protein sequence ID" value="QAS60086"/>
        <property type="gene ID" value="EI377_04550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <position position="76"/>
        </location>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="203" mass="23067" checksum="A4CE8895E054B3E3" modified="2018-12-05" version="1">MKKLIIASNNQKKIKEIKEILKEVQLKVVSLEDENINIDVVENGKTFEENARKKATEICDYLLNRGDKDFIVLGDDSGLEVEYLKGAPGIYSARYAGEHGNNEKNNEKLLENLKGIKSEDRKARFVCQLALINDKKVYKAITGYVEGYILEELSGTKGFGYDPLFYYEPLKKSFGEATAEEKNGISHRGMALRKFKDEIKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF72</accession>
    <name>A0A386PF72_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_01055</name>
        <name evidence="12" type="ORF">EI377_11550</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02308"/>
    <dbReference type="EnsemblBacteria" id="AYE33142">
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
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        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
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        </location>
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            <end position="269"/>
        </location>
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            <end position="561"/>
        </location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="563" mass="64205" checksum="939EBD702D60F270" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF79</accession>
    <name>A0A386PF79_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heme ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33528">
        <property type="protein sequence ID" value="AYE33528"/>
        <property type="gene ID" value="CP523_03125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03125"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
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            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="518" mass="59160" checksum="BE2F3A5E79243E5A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB2</accession>
    <name>A0A386PFB2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">CP523_10135</name>
        <name evidence="13" type="ORF">EI377_04935</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676608.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00356"/>
    <dbReference type="EnsemblBacteria" id="AYE34733">
        <property type="protein sequence ID" value="AYE34733"/>
        <property type="gene ID" value="CP523_10135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60134">
        <property type="protein sequence ID" value="QAS60134"/>
        <property type="gene ID" value="EI377_04935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10135"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="209" mass="22964" checksum="C54D329AD801C850" modified="2018-12-05" version="1">MSKVTQIDHPLILHKLAFIRNKDTGAKDFRELVEEVSMLMAYEVTRDLSTEEVEIETPICKAKCQMLAGKKMAIVPILRAGLGMVDGMLKLIPAAKVGHVGLYRDEETLQPVEYFCKLPQDIAERDVIVVDPMLATGGSAADAIQILKKRGAKNLRLMCLISSPEGIEFVQKAHPDVDIYVGGIDEKLNEQGYIVPGLGDAGDRLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE1</accession>
    <name>A0A386PFE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3021 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF3021 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04265</name>
        <name evidence="3" type="ORF">EI377_14790</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33741">
        <property type="protein sequence ID" value="AYE33741"/>
        <property type="gene ID" value="CP523_04265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62234">
        <property type="protein sequence ID" value="QAS62234"/>
        <property type="gene ID" value="EI377_14790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021560">
        <property type="entry name" value="DUF3021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11457">
        <property type="entry name" value="DUF3021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="44" mass="4684" checksum="B5F21F577219A698" modified="2018-12-05" version="1">MYATGSEINAVILHTILSGLVGSAFAGSSVIWEMDNWSIAKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI4</accession>
    <name>A0A386PFI4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ornithine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03720</name>
        <name evidence="6" type="ORF">EI377_14250</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677685.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02201"/>
    <dbReference type="EnsemblBacteria" id="AYE33638">
        <property type="protein sequence ID" value="AYE33638"/>
        <property type="gene ID" value="CP523_03720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61802">
        <property type="protein sequence ID" value="QAS61802"/>
        <property type="gene ID" value="EI377_14250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00615">
        <property type="entry name" value="Orn_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005308">
        <property type="entry name" value="OKR_de-COase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011193">
        <property type="entry name" value="Orn/lys/arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027464">
        <property type="entry name" value="Ornithine_deCO2ase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03709">
        <property type="entry name" value="OKR_DC_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009393">
        <property type="entry name" value="Orn_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00703">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="4">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="733" mass="83153" checksum="D760A81086F5B893" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP3</accession>
    <name>A0A386PFP3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02125</name>
        <name evidence="6" type="ORF">EI377_12645</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674069.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00541"/>
    <dbReference type="EnsemblBacteria" id="AYE33342">
        <property type="protein sequence ID" value="AYE33342"/>
        <property type="gene ID" value="CP523_02125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61512">
        <property type="protein sequence ID" value="QAS61512"/>
        <property type="gene ID" value="EI377_12645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="331" mass="37465" checksum="8B11B1ABC730DCF6" modified="2018-12-05" version="1">MATIKDIANLVGVSSSTVSRVLNFDETLNVTDETKMKIFQVADELEYVSVRNRKKNKTQIIGILHWYTAEQELGDPYYLSIRLAVEKKCQEQKINTITVHSESCIDQLKNVDGIIAIGKFSFEEIEFIKKITNNIVFVDSSPNGSLYDSVVIDFREAVKVALDYLVDLGHTKIAYLGGKETYRDGIEYITDEREMTFIEYTKSKGIFNEDLIGIGDFTHKDGYKLMKKLLEGNDIPSACFIASDTMAVGAYKAVAEKDLKIPEDISILSFNDIPTAKYMIPSLTTIRVYTEFMGMSAVDLMLENIISNRCYRKKVVINAELKIRESCIKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP5</accession>
    <name>A0A386PFP5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_04035</name>
        <name evidence="11" type="ORF">EI377_14555</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02779"/>
    <dbReference type="EnsemblBacteria" id="AYE33698">
        <property type="protein sequence ID" value="AYE33698"/>
        <property type="gene ID" value="CP523_04035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61853">
        <property type="protein sequence ID" value="QAS61853"/>
        <property type="gene ID" value="EI377_14555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="302"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="519" mass="59918" checksum="DF1A2BE79011922D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU2</accession>
    <name>A0A386PFU2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">pfkA</name>
        <name evidence="17" type="ORF">CP523_06335</name>
        <name evidence="18" type="ORF">EI377_00805</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677772.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02426"/>
    <dbReference type="EnsemblBacteria" id="AYE34114">
        <property type="protein sequence ID" value="AYE34114"/>
        <property type="gene ID" value="CP523_06335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59480">
        <property type="protein sequence ID" value="QAS59480"/>
        <property type="gene ID" value="EI377_00805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06335"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="3"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS59480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="34050" checksum="79B3139B071DA44E" modified="2018-12-05" version="1">MKKIAILTSGGDAPGMNAAIRAVVRSALHNGLEVMGVQRGYSGLINGELFNMDRSSVSDIIHRGGTILRTARCLEFKQEEVRVKATKILQAYGVDALVVIGGDGSFMGAKLLSKLGIKTIGLPGTIDNDLTYTDYTIGFDTALNTVIDAIDKIRDTSTSHERVSIVEVMGRDCGDLALYAGLAGGAEYIITPEKGYTKEELCKVILEGKQKGKIHSLVLLAEGVGGAQELAEYVEGVTGIETRATVLGHIQRGGSPSAADRVLASRMGAKAIEVLLNGGTSRVIGIRNNEIIDQDIDEALALDRTFDEKLFKTAEEINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV8</accession>
    <name>A0A386PFV8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11200</name>
        <name evidence="3" type="ORF">EI377_05990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677049.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00900"/>
    <dbReference type="EnsemblBacteria" id="AYE34933">
        <property type="protein sequence ID" value="AYE34933"/>
        <property type="gene ID" value="CP523_11200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60327">
        <property type="protein sequence ID" value="QAS60327"/>
        <property type="gene ID" value="EI377_05990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="361" mass="41887" checksum="DC601BBF389DF503" modified="2018-12-05" version="1">MKFSEAINTVELVLESGDVPLIIGEAGIGKTALIKKLSSKKEFYLVTIDANLLKEGEIGGLPIVENSRTIYATHYKLLEVDRAINESKNKGVILFIDELNRCEHAVQQELMNLILNREINGYKLDKEVKIVAAMNPSNKYEGFEDSDYQVVDMDRAQEDRFVWIEMDSDVKEWIKWAMGKERNIHEHIIEFISTFPEYLNNPSSRESVKSSPRSWERIGKSYNVYKNSNGKFSIDTFYNVVKGNVGVNIATDFINYIKNTKRPLIKAKELFSYNVLPIELKEEIQKESHSRLYILAKNCLSYLEENKNDKDIKLFGDLLMVYPRDLRLGIMKEIRSDESKELYKLLLNEDTFLEAFFNIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW0</accession>
    <name>A0A386PFW0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0178 protein CP523_09665</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09665</name>
        <name evidence="4" type="ORF">EI377_04445</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0178 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02639"/>
    <dbReference type="EnsemblBacteria" id="AYE34670">
        <property type="protein sequence ID" value="AYE34670"/>
        <property type="gene ID" value="CP523_09665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60070">
        <property type="protein sequence ID" value="QAS60070"/>
        <property type="gene ID" value="EI377_04445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="16841" checksum="D2AEED831732830B" modified="2018-12-05" version="1">MKIIVDGDACPGISIIQNIAEEYKIELLLYCDIHHFIMLDYGEVKVVDTGFQSVDMYVVNNCKNKDIVITQDYGVAAICLGKNAKVINPKGYVYNNENIDRLLEERHISQKIRRAGGRTSNPKKRVVEDDIRLEKNLKKLIECSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ4</accession>
    <name>A0A386PFZ4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ORF">CP523_00835</name>
        <name evidence="11" type="ORF">EI377_11330</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674589.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02352"/>
    <dbReference type="EnsemblBacteria" id="AYE33099">
        <property type="protein sequence ID" value="AYE33099"/>
        <property type="gene ID" value="CP523_00835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61269">
        <property type="protein sequence ID" value="QAS61269"/>
        <property type="gene ID" value="EI377_11330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="160"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="26774" checksum="9DF211C934617DF0" modified="2018-12-05" version="1">MNRFNIKEVEKTIGFSFNENKLLKTALTHSSYANQHKDQEYNERFEFLGDAILQLCVTEYLFLNYKNKSEGELTKIRSLIVCENSLYEIGKKLNLGNFLRISRGEELTGGRERVSIIADSVEALIAAIYLDKGLEFVKDFILGYFEEIITMAINNDIVLDYKTKLQEELQKSGEVSIVYELLKYEGPPHRRKFFTAVIIDHKEFGKGEGYSKKESEQNAAKEALKLLEEMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ5</accession>
    <name>A0A386PFZ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10015</name>
        <name evidence="2" type="ORF">EI377_04800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00332"/>
    <dbReference type="EnsemblBacteria" id="AYE34710">
        <property type="protein sequence ID" value="AYE34710"/>
        <property type="gene ID" value="CP523_10015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60111">
        <property type="protein sequence ID" value="QAS60111"/>
        <property type="gene ID" value="EI377_04800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="31268" checksum="2FAAE2A9D0A56EDC" modified="2018-12-05" version="1">MINIESKEINSYLGNRNIKIINEKFKGKDLINEEEIAFQVDLIVRFHKLIGEYKENLIPRIGSNIGKDLEYYKFQLKRLKADLEYRKTKQEKNLLDLNIISNGNELLNKGEKAINHILRNNYKKLIQRSMTNYEVCLGKVDDSNLRYTVSIEDGIEINTIKYLSYNLKEHDLYNYIKRLKKKDIPIEANKIIEYYVDSLGLSIDSMEYLKGFIYYPNESLRIWDKYILNKKELSFDKYLNDFKKGQIIDNIYIDEIIGGDFGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG21</accession>
    <name>A0A386PG21_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_06720</name>
        <name evidence="9" type="ORF">EI377_01190</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679138.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01564"/>
    <dbReference type="EnsemblBacteria" id="AYE34184">
        <property type="protein sequence ID" value="AYE34184"/>
        <property type="gene ID" value="CP523_06720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59548">
        <property type="protein sequence ID" value="QAS59548"/>
        <property type="gene ID" value="EI377_01190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="121" mass="13424" checksum="83CA7872EA817B0A" modified="2018-12-05" version="1">MEKFLKFGLVGVINTLITMIVFNGLKFIGVNILVANTIGYICGMINSYLWNNRWVFKSNTKDVSTISKFIIVNVVAMLINNGILFVFVNGVGINSTISQALAIVITTVINFVGNKIWTFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG47</accession>
    <name>A0A386PG47_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LAGLIDADG_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03760</name>
        <name evidence="3" type="ORF">EI377_14290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675393.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33646">
        <property type="protein sequence ID" value="AYE33646"/>
        <property type="gene ID" value="CP523_03760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61810">
        <property type="protein sequence ID" value="QAS61810"/>
        <property type="gene ID" value="EI377_14290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00961">
        <property type="entry name" value="LAGLIDADG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAGLIDADG_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="16119" checksum="B449C755D81905EC" modified="2018-12-05" version="1">MNEIEKSYIAGIIDGEGSIMLEKIHKNNYPSPVISVTSTTIELLEYLKATIGFGKITKKTNYNIEKHKNCYTFVVNYNNAINLLKDVYPYLIIKSKKLRAKMIIEEYKNLTPRNGRYSEELLKEKYYFYRRFREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA8</accession>
    <name>A0A386PGA8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
            <ecNumber evidence="1">2.7.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AnhMurNAc kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">anmK</name>
        <name evidence="2" type="ORF">CP523_05995</name>
        <name evidence="3" type="ORF">EI377_00475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,6-anhydro-N-acetyl-beta-muramate + ATP + H2O = ADP + H(+) + N-acetyl-D-muramate 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:24952"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58690"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.170"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; 1,6-anhydro-N-acetylmuramate degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anhydro-N-acetylmuramic acid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01901"/>
    <dbReference type="EnsemblBacteria" id="AYE34051">
        <property type="protein sequence ID" value="AYE34051"/>
        <property type="gene ID" value="CP523_05995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59423">
        <property type="protein sequence ID" value="QAS59423"/>
        <property type="gene ID" value="EI377_00475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05995"/>
    <dbReference type="UniPathway" id="UPA00343"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097175">
        <property type="term" value="P:1,6-anhydro-N-acetyl-beta-muramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01270">
        <property type="entry name" value="AnhMurNAc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="PTHR30605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="382" mass="41838" checksum="5BB9AD861305EAD9" modified="2018-12-05" version="1">MYSVGLMSGTSLDGVDAALVEIIDYGIDTKIKLMEFITLDIPRDIKEEIKLSCHEEKSSVDLICSLNFKLGYLFSNAVKEVCKKAKFSLENLDFIATHGQTIYHIPKKRGSLIPSTMQIGEPAIIAYETGVKVISNFRVMDMAAGGEGAPLVPFSEFVLYGSREESIALQNIGGIGNVTVIPNTGNINDVFAFDTGPGNMIIDDVCQRLFGASYDEDGKFASKGMVNNTMLIDLMSHPYILSKPPKSTGREEFGQKYVDEILEKYKMLKSEDILATVTMFTAKSISENYKKFILSKVNLKKIVIGGGGAHNKTLLKYIKEELPNIKIVTQDELGFSSDAKEAIAFVILGNETLNESFSNVPSATGATNKVILGNITPSPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB8</accession>
    <name>A0A386PGB8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12195</name>
        <name evidence="2" type="ORF">EI377_07015</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673565.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35115">
        <property type="protein sequence ID" value="AYE35115"/>
        <property type="gene ID" value="CP523_12195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60506">
        <property type="protein sequence ID" value="QAS60506"/>
        <property type="gene ID" value="EI377_07015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="109" mass="12995" checksum="D04246CF8C8AB0C5" modified="2018-12-05" version="1">MVEEYISAIEASKKFNLYLKVVNSVSTFDSYNSFFNIFDQYEEYCRRIVILTPYKELEEVYEVDPGEKIEEAIIREGNMWIKEYPLTTKPEDICMESLFIPKELLEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF3</accession>
    <name>A0A386PGF3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02217"/>
    <dbReference type="EnsemblBacteria" id="AYE33622">
        <property type="protein sequence ID" value="AYE33622"/>
        <property type="gene ID" value="CP523_03640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="154"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="388" mass="45364" checksum="96B73DF04B8AA916" modified="2018-12-05" version="1">MEDLKKAINEIAKEEIIKIIVSNKTNKDIKYNKISFILKENSKKKKYYQIEKYTDKQVFHENIETNALEKKLMEYVSSNYKQVGAWSSETTFDLKISKKGKVHLGKKKSNNLKLVNKGHNKEKNYILKEGMIIEPLIDLGIFTKEGKVINSKYDKYKQINRFIEIVDDEIKKNDYKELNILDFGCGKSYLTFVLYYYFVQIKKIKVKMIGLDLKEDVIKKCNEIAKRYNYENLHFELGDINGFKYNNKVDMVITLHACDTATDYALYNAIKWNSKMIFSVPCCQHEFNAQMKTESLTILTKYGIIRERMAALMTDSVRANLLECLGYKTQLLEFIDIAHSPKNILIRASKTNISKEKKEKALNEVKALMKEFNFNPTLFNLLENDNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI0</accession>
    <name>A0A386PGI0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12440</name>
        <name evidence="4" type="ORF">EI377_07325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675331.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02025"/>
    <dbReference type="EnsemblBacteria" id="AYE35163">
        <property type="protein sequence ID" value="AYE35163"/>
        <property type="gene ID" value="CP523_12440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60566">
        <property type="protein sequence ID" value="QAS60566"/>
        <property type="gene ID" value="EI377_07325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07046">
        <property type="entry name" value="BMC_PduU-EutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009307">
        <property type="entry name" value="EutS/PduU/CutR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40449">
        <property type="entry name" value="PTHR40449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012296">
        <property type="entry name" value="EutS_PduU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="2">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="117" mass="12517" checksum="1A7C3822AC95424D" modified="2018-12-05" version="1">MEDFLDGKIQRIVQESVPGKQITIAHVIASPMPDIYERLGIDEKGAIGILTLSPYETAIIAADIATKVADVNIGFLDRFTGSVVISGDVQSVETALDAVNNTLRDMLGFTPAAITRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS3</accession>
    <name>A0A386PGS3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13100</name>
        <name evidence="3" type="ORF">EI377_07970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35285">
        <property type="protein sequence ID" value="AYE35285"/>
        <property type="gene ID" value="CP523_13100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60679">
        <property type="protein sequence ID" value="QAS60679"/>
        <property type="gene ID" value="EI377_07970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="192" mass="22290" checksum="7023BAACB5DC2C69" modified="2018-12-05" version="1">MDIFTLDNKERFISLLKDTKREGVENLIKWLEGTDFFIAPASTRFHSNYEGGLCQHSLNVYKIFKKKCEDNEIELDESNIIIASLLHDICKANYYVVSSRNVKRDGKWIQVPYYSVDDQNPLGHGEKSCLILQTFIKLTKEELYCIRWHMGGYEPKENLNTISAAWNLCKPAVLLHTADLEASYLIEEHREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU2</accession>
    <name>A0A386PGU2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_06290</name>
        <name evidence="12" type="ORF">EI377_00765</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677760.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02417"/>
    <dbReference type="EnsemblBacteria" id="AYE34108">
        <property type="protein sequence ID" value="AYE34108"/>
        <property type="gene ID" value="CP523_06290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59475">
        <property type="protein sequence ID" value="QAS59475"/>
        <property type="gene ID" value="EI377_00765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="26497" checksum="BE9915030555F669" modified="2018-12-05" version="1">MAYTILIAEDDPDIVELLRLYLSGEGYNVVSVDNGIDALEITENQKIDLAVIDVMMPGMNGYNVTEEIRKHSNIPIIILSAKNQEYDKILGLNIGADDYMTKPFSPIEIIARINSNLRRFYQLGSNNLDIKKNSKVSLGEICIDIESFKVEKNGHPVNLAPMEFKILVKLMKSPGRVFTKTQIYQSVCGEFFESDDNTMMVHISKLREKLEDDPKNPRYIKTIRGLGYKFENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW5</accession>
    <name>A0A386PGW5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677497.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00758"/>
    <dbReference type="EnsemblBacteria" id="AYE35325">
        <property type="protein sequence ID" value="AYE35325"/>
        <property type="gene ID" value="CP523_13310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="349" mass="39310" checksum="2DFFA56913A3375C" modified="2018-12-05" version="1">MLKIERMISPYNHYEGNAIKYIVVHGTGAPEGTDSARNNAIYFYGGNRNASAHYFVDATSIYQSVEDFNGSWSVGDGYNQYGINNQNTLNIEMCCNNYTYDEGTIVNTLELVKVKQKEYGIPNSNVVRHFDASRKVCPEYFSLNNWEKWSNFIERLTGETVQQSKPVQKPSYNHGEGKYLNLHSHMEKWAIYATNVRPVTGNQKGYLKPKMFGGLSYKIIEDRGDVKIINTGDYGTVQIYAPNDADSSITDKPIYNNIAGPNPAPPVINVSYLNLHEHNYSWRVYPLNVPPVVGNECGALAPAQYGGLSYKILEKKITDVYKIKTESFGVVAIYAPRDNDSSITEKPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX2</accession>
    <name>A0A386PGX2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04605</name>
        <name evidence="3" type="ORF">EI377_15160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675828.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33802">
        <property type="protein sequence ID" value="AYE33802"/>
        <property type="gene ID" value="CP523_04605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61959">
        <property type="protein sequence ID" value="QAS61959"/>
        <property type="gene ID" value="EI377_15160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="108" mass="12721" checksum="28177543DADC9ACF" modified="2018-12-05" version="1">MKEDQFNKLIKNSLMDECTLSPEEALIETTKNLIKKKKRRDLWINKMYILFLVLICLIFSIKAIYLSIQSQNITLILSLTLSFACVLILNFIYRYEIINFLKIKGDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX8</accession>
    <name>A0A386PGX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13350</name>
        <name evidence="2" type="ORF">EI377_08240</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35333">
        <property type="protein sequence ID" value="AYE35333"/>
        <property type="gene ID" value="CP523_13350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60723">
        <property type="protein sequence ID" value="QAS60723"/>
        <property type="gene ID" value="EI377_08240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="217" mass="24733" checksum="E377B6CEFD6058BA" modified="2018-12-05" version="1">MQFLKLSTELITDNNITSNEFRIYSYLLSLYNVEKQCSYPSIDIISERLNISISTVKRSIKRLAELGYISIEKRKGLAGNFNVYKKLKHLINNVVKTKKVNKIAIDSNGEKAIEGQISVEEALEDIEETKVRTNIIDNSSNVRLARSVTNIDNSSFAKKVLSLSDNGLVRAAIKEFKKKRGKTPTFLIKLLVDQYYKEGIDLSKPLLNLLKRDYIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ0</accession>
    <name>A0A386PGZ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33822">
        <property type="protein sequence ID" value="AYE33822"/>
        <property type="gene ID" value="CP523_04710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="166"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="542" mass="62892" checksum="66D4BC5939E1FABB" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ4</accession>
    <name>A0A386PGZ4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_05050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33886">
        <property type="protein sequence ID" value="AYE33886"/>
        <property type="gene ID" value="CP523_05050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="146" mass="15323" checksum="4A5D793804CB6037" modified="2018-12-05" version="1">MDIYKLYSISRKLYEKKIPIIPKLIKGLIRIVFSCVIPFTAKIGEGTKIGYQGLGVVIHSNSIIGTNCAISQGVTIGGTSKKKGVPIIGNNVYIGAGAKIIGPITIGDNVVVGANAVVLKDVPSGCVVVGIPAKIIKTNILMSDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH16</accession>
    <name>A0A386PH16_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13630</name>
        <name evidence="3" type="ORF">EI377_08520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35385">
        <property type="protein sequence ID" value="AYE35385"/>
        <property type="gene ID" value="CP523_13630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60774">
        <property type="protein sequence ID" value="QAS60774"/>
        <property type="gene ID" value="EI377_08520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="108" mass="12371" checksum="D4024BCF8BC17C48" modified="2018-12-05" version="1">MRGQHYTDEQKEQILQEVKEVGNVSLVGRKHGISTSTIFTWISKSKNRNQIKTKPGRKTSVEGKSNEEEINEVTQENDKLKKILGEKDLEISILKDLLKKANPQLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH20</accession>
    <name>A0A386PH20_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13565</name>
        <name evidence="3" type="ORF">EI377_08460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
            <end position="30"/>
        </location>
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            <begin position="31"/>
            <end position="162"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60763.1"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
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            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="EMBL" id="AYE33882.1"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="68" mass="7846" checksum="7A6526F85D38BD72" modified="2018-12-05" version="1">MSLAELSNEYGIAKSTINCWIKDVKEIKVDENEVMTLKEVKELKKEMARIKDENEILKKAMAIFATKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH44</accession>
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        </submittedName>
    </protein>
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                <person name="Leendertz F.H."/>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AYE33926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="265" mass="31113" checksum="F3A265B9EDB4847A" modified="2018-12-05" version="1">MNGAKWYSLSRKGKFGLSITFYIIFLVYLCYLIINAENTSVKVLYGVILIFFGSFAFLYEVLKKLNDKAIYTLIELCDPIEAERIMKKLEKYDYLKGFKSSNRVFKLLLLKDMGKYKEIIEYLDKEGKKSFSTSLDLLLVYYYFYFFAYASLNDIDNAKVYYEHVMKLENAKIGRKRVLPVFSWDEITGHYMLLLNKFKDSKKAFKAVSVENMNMHEKVNYHLLVAKLYIETKDKNLAEKNLKFVLSNGNKMHATEEASKLIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH65</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 4">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="113"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="120" mass="13667" checksum="0230B2840F1FE2CB" modified="2018-12-05" version="1">MSREMNNLLRKMIKCDLVGGLISALIVSLLVNLQIASIFFMGILVALVNFLVSGIILEYSLIRDKKLLIIMSYFIKIIVIVCLALPFMYNLQKLIAYVGGYISHFILLTFYWLKNEKGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 7534</strain>
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    <reference evidence="4" key="2">
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE34401">
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        <property type="gene ID" value="CP523_08165"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59807"/>
        <property type="gene ID" value="EI377_02920"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362718" evidence="2">
        <location>
            <begin position="27"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="145"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="29644" checksum="06E3730D83A501AC" modified="2018-12-05" version="1">MIHYKIIKLLISLGMVPALCLGTAYGTSKITNKEKEPQAVEVKSPEESHKVEENKKVGQVNNDSNAKTEKVEIAQSNEKQTEEAKQNSNTTNESNGSVANPSKETGVNESSNTEQQPESQEAKKETPSANQDDSYISEIEQLIFQQVNQQRQAAGLQPLSYNSTMEHYARVKSKDMGVRRYFDHTNPEGQLITAQMKADGVSYNAWGENIAYIGGVSGNSNLANQFMTNWMNSPGHRANILSSNFTSIGVGVYKIGNKYYATQEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH79</accession>
    <name>A0A386PH79_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12375</name>
        <name evidence="5" type="ORF">EI377_07260</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675353.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02038"/>
    <dbReference type="EnsemblBacteria" id="AYE35150">
        <property type="protein sequence ID" value="AYE35150"/>
        <property type="gene ID" value="CP523_12375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60553">
        <property type="protein sequence ID" value="QAS60553"/>
        <property type="gene ID" value="EI377_07260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="53"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="369"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="594" mass="67137" checksum="084B8CF44E044712" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH90</accession>
    <name>A0A386PH90_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsZ</name>
        <name evidence="7" type="synonym">rpsN</name>
        <name evidence="8" type="ORF">CP523_09040</name>
        <name evidence="9" type="ORF">EI377_03785</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876952.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34554">
        <property type="protein sequence ID" value="AYE34554"/>
        <property type="gene ID" value="CP523_09040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59954">
        <property type="protein sequence ID" value="QAS59954"/>
        <property type="gene ID" value="EI377_03785"/>
    </dbReference>
    <dbReference type="GeneID" id="66300467"/>
    <dbReference type="KEGG" id="csep:CP523_09040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="7220" checksum="D793D687E067378A" modified="2018-12-05" version="1">MARKAIIEKWKREPKYSTRAYTRCRICGRPHSVLKKFGICRICFRELAYKGQIPGCKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB2</accession>
    <name>A0A386PHB2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05415</name>
        <name evidence="4" type="ORF">EI377_15975</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677970.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02586"/>
    <dbReference type="EnsemblBacteria" id="AYE33952">
        <property type="protein sequence ID" value="AYE33952"/>
        <property type="gene ID" value="CP523_05415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62103">
        <property type="protein sequence ID" value="QAS62103"/>
        <property type="gene ID" value="EI377_15975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="464" mass="54596" checksum="DC620A3C2046BF03" modified="2018-12-05" version="1">MSKKYIFPKSFWWGAATSGPQSEGRFNKIHKSVFDYWFDIAPEVFFNEVGPNVASNFYNSYKEDLAMFKEIGFNSFRTSIQWTRLIKDFETGEPDEDGVRFYNDVIDESLKNGIIPVMNLHHFDLPVELYDKYGGWESKHVVDLFVKFAETAFKLFSDRVKYWATFNEPIVVVEGQYLYKFHYPQIVDGKKAVQCLYNLNLASAKVIKAFRELGCEKEGGKIGIILNLTPAYPRSNNEEDVKAAKFADSFFNNSFLDPAVKGEFPRVLTAVLEKDEVMFQFTEEEMKIIKENTVDFLGVNYYQPRRVKAKESEYKENTWMPDKYFDNYEMPGRRMNPYRGWEIYPQCMYDIAKNIRENYNNIPWYISENGMGVEGESRYINKDGVIEDDYRIDFYKEHLEYLHKGIMEGSNCFGYHAWTPIDCWSWCNSYKNRYGFISVDLETQKKTIKKSGRWIKEVSDNNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ2</accession>
    <name>A0A386PHJ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14680</name>
        <name evidence="5" type="ORF">EI377_09645</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678854.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PHJ2"/>
    <dbReference type="STRING" id="1504.GCA_900092375_00138"/>
    <dbReference type="EnsemblBacteria" id="AYE35575">
        <property type="protein sequence ID" value="AYE35575"/>
        <property type="gene ID" value="CP523_14680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60961">
        <property type="protein sequence ID" value="QAS60961"/>
        <property type="gene ID" value="EI377_09645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="6"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="326" mass="36360" checksum="AAF3D9ACE787178D" modified="2018-12-05" version="1">MMKRKVIIDCDPGIDDSLALILALTSEELEVVGITIVSGNVNANKGAKNAMKVLKLMGREDIKVFIGEEKPLIRELITAEDTHGSDGLGEAGHQYIDTDEKINYGAVDFILEKAKEGDLSIIALGPLTNLARAIEKDKEGFNNILEVVSMGGAFKSHGNCSQVAEFNYWVDPHGAKYVFDKIEVPFTMVGLDVTREIILTPNYIELIKQIGGEIAEFIVNITKFYVDFHWKQERTLGCVINDPLAVAYFIDRKLAIGFTSYIDVVTEGAAIGQTLVDVGEFYKKKHNALVLTEVDSKKFMKFFLERIFKENKNDINLILNNNKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK0</accession>
    <name>A0A386PHK0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF421 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_10820</name>
        <name evidence="11" type="ORF">EI377_05605</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0702 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677605.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02498"/>
    <dbReference type="EnsemblBacteria" id="AYE34857">
        <property type="protein sequence ID" value="AYE34857"/>
        <property type="gene ID" value="CP523_10820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60251">
        <property type="protein sequence ID" value="QAS60251"/>
        <property type="gene ID" value="EI377_05605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="257" mass="28825" checksum="2BE1D0EFAC514B41" modified="2018-12-05" version="1">MFIVLIRTIILYALVVFVMRLMGKRQIGELQPYEFVITIMISDLAALPMQDTRLPLILGVIPIITLLFVKTLLTQLQLKSQLARKIIEGEPSILICRGKVNFSALKKQQINLDELMEELRLAGYFDLSEIEYAILENNGQLSFLTSQSSSSSSNSTDCSNTQSNSNGNSSDQTNTSNSNKSNSSKNQSKPRLPIIYVLDGEVNNNALTSSGKNKVWVKNELKKHKIDSIDKVLLAMTDTTGKFIYQLYDDYEKGCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM8</accession>
    <name>A0A386PHM8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rph</name>
        <name evidence="7" type="ORF">CP523_09745</name>
        <name evidence="8" type="ORF">EI377_04545</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676745.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02655"/>
    <dbReference type="EnsemblBacteria" id="AYE34684">
        <property type="protein sequence ID" value="AYE34684"/>
        <property type="gene ID" value="CP523_09745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60085">
        <property type="protein sequence ID" value="QAS60085"/>
        <property type="gene ID" value="EI377_04545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="27766" checksum="7105382ACD20C295" modified="2018-12-05" version="1">MRIDGRKNDQVRSTKITRNYTKYAEGSVLIEVGDTKVICTASIEDKVPPFLKGKGEGWITAEYNMLPRSTGTRKPRDIARLKIDGRTMEIQRLIGRALRSVVDFKALGERTIWIDCDVIQADGGTRTTSITGSFVALVDAVNKLHKEKPFKIYPIRSFVSATSVGIVNGEKIIDLCYEEDSNAMVDMNIVATDEGEFIEVQGTGEEAPFKRSELNELLDLAEKGVKQMIQIQKEALKMDCLWIGTGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS6</accession>
    <name>A0A386PHS6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10140</name>
        <name evidence="5" type="ORF">EI377_04940</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676610.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00357"/>
    <dbReference type="EnsemblBacteria" id="AYE34734">
        <property type="protein sequence ID" value="AYE34734"/>
        <property type="gene ID" value="CP523_10140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60135">
        <property type="protein sequence ID" value="QAS60135"/>
        <property type="gene ID" value="EI377_04940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18847" checksum="3DE7C5028220062D" modified="2018-12-05" version="1">MDRRDKHNYYLDIAETVLERGTCLRRNYGSIIVKNDEIISSGYTGAPRGRKNCIDIKTCIREKLNIPRGTHYELCRSVHSEANAIISASRRDMIGATLYLVGRDVNDKEYVLNANSCSMCKRMIINAGIKEVIIRDSKNKYRSILVDSWIYEDDSLDIKLEMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY6</accession>
    <name>A0A386PHY6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_13760</name>
        <name evidence="10" type="ORF">EI377_08650</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677151.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02070"/>
    <dbReference type="EnsemblBacteria" id="AYE35410">
        <property type="protein sequence ID" value="AYE35410"/>
        <property type="gene ID" value="CP523_13760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60798">
        <property type="protein sequence ID" value="QAS60798"/>
        <property type="gene ID" value="EI377_08650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="414"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="662" mass="77270" checksum="D29D799DA472CAE6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI39</accession>
    <name>A0A386PI39_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ORF">CP523_10175</name>
        <name evidence="8" type="ORF">EI377_04990</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676639.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00364"/>
    <dbReference type="EnsemblBacteria" id="AYE34741">
        <property type="protein sequence ID" value="AYE34741"/>
        <property type="gene ID" value="CP523_10175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60143">
        <property type="protein sequence ID" value="QAS60143"/>
        <property type="gene ID" value="EI377_04990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="179" mass="21119" checksum="60576AC2F00CFFE0" modified="2018-12-05" version="1">MYEYLDRRYALALYEVAEEKGKVQQYLQDLREICNLIDTNKEFYEVIKHPQISTKKKKKTFINIFKGHIDEELLSFLLILIEKDRILYLREKLKEMEKIDLERKNTLNGVIKTTVSLTDEEFNSLKSKLEKKYNKHVILEQIIDKSILGGIYVRVGNDVIDGTVKSKLDELQDLMLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI53</accession>
    <name>A0A386PI53_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10755</name>
        <name evidence="3" type="ORF">EI377_05540</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674100.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34844">
        <property type="protein sequence ID" value="AYE34844"/>
        <property type="gene ID" value="CP523_10755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60238">
        <property type="protein sequence ID" value="QAS60238"/>
        <property type="gene ID" value="EI377_05540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="321" mass="36554" checksum="92FED0963ABB3A22" modified="2018-12-05" version="1">MPIIDMPLERLREYKGTNPIPEDFDSFWDKRMEEVQKHPLEYKIIPSEIIGNDSCGFYDLWFKGINGENLYAKYIRPKIEYDLPIILQFHGYPGASRGWFEQASFAGMGCAILAMDCPGQGGNGEDVGGFKGTTVSGHIIAGLDGDPKDMYYVRLFQNVSILCRIAEELEGIDKNRIYANGASQGAGITLACSSLNPVIKRCAALYPFLSDYKRVWDMDLDLVAYEGLRYYSRWFDTMGERNEKVFMNLGYIDVHNLAHRLQAEILFGTGLMDNICPPSTQFAVYNNITSKKKHVIFPDYTHEEIGVFDDMLIDFFLKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI97</accession>
    <name>A0A386PI97_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Toxic anion resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05345</name>
        <name evidence="4" type="ORF">EI377_15910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TelA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02599"/>
    <dbReference type="EnsemblBacteria" id="AYE35823">
        <property type="protein sequence ID" value="AYE35823"/>
        <property type="gene ID" value="CP523_05345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62246">
        <property type="protein sequence ID" value="QAS62246"/>
        <property type="gene ID" value="EI377_15910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026508">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="438" mass="49862" checksum="3185057CC70D8F2C" modified="2018-12-05" version="1">MGQPFNENNANTVDYQPVNNANGFGGFNENQQQNLYNQQQGYGQQPQGGYTQQGYGQQPQGSYAQQGYGQQHQGIMTQYNQEMPMQTEEFNFNEISEYKQRLRSLKEVQNLTNEIEIQNPNSIIMFGQVASENISKVSDQLLSSMKSVKAEEASEMLVNLTKIMDKFDIKEIEGSQKPSMLSKFVKGIGNSVAKLFQKYDTMGYEVEKVYVLLRKYETDIKESNANLKKIYDANIHFYQLLEKYIVAGELALEEIDGLISQFALNTSMNEEEKRMLTQKLEISKEMLSQRIYDLQIAENVAIQAAPMIQTIQMSNFNLMRKINSSFIVTLPIFKQCLAQAVILKRQEIQAKSIKQLDEKTNELIMRNAANTARQSVEIAKMASGSSVAISTLEKSYETIMKGIEETKAIQEANRVERAENSVKLETIKHKMKKNIANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID2</accession>
    <name>A0A386PID2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09365</name>
        <name evidence="3" type="ORF">EI377_04110</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02730"/>
    <dbReference type="EnsemblBacteria" id="AYE34618">
        <property type="protein sequence ID" value="AYE34618"/>
        <property type="gene ID" value="CP523_09365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60018">
        <property type="protein sequence ID" value="QAS60018"/>
        <property type="gene ID" value="EI377_04110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="54" mass="5975" checksum="98ADB72A0F680EED" modified="2018-12-05" version="1">MLWKVIKCEATNCIHNNNCQCEAESVDVAGVSACTSEQTECSSFCCRIKNVIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM0</accession>
    <name>A0A386PIM0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF5050 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08685</name>
        <name evidence="4" type="ORF">EI377_03435</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01678"/>
    <dbReference type="EnsemblBacteria" id="AYE34492">
        <property type="protein sequence ID" value="AYE34492"/>
        <property type="gene ID" value="CP523_08685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59894">
        <property type="protein sequence ID" value="QAS59894"/>
        <property type="gene ID" value="EI377_03435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="DUF5050"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362746" evidence="1">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5050" evidence="2">
        <location>
            <begin position="109"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="330" mass="37321" checksum="34D6D740E7D88B59" modified="2018-12-05" version="1">MLKKAIPLVLLSSFFLTACSAAEKAKNETKDKNNKIEISQPTTPPNSNLTLVDKSITYSPYLNLGNLIFFPDKENNNKLSTTEKSTSNSYVLNDNIKDTFNYPVESLITIDNSIYFSNTSDNNSLYKLDYQRNEFTKVNNNSVYNLTSQSKELYYINRTDNNKLYHYNLANSTSYSLSDDSCGKFIINGNSILYQNLSDGAKLYSISIDGNNRKKLTDNSVDSFTVYSGQILFINSDENNSLYKLDVKSERTNKIASINGTELKNSNNKLYFINIASGNNLCSLSVDLNKNEAKASQITTDSINQYYLNDNEIFLDKTLDVNKTYVIKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN0</accession>
    <name>A0A386PIN0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_15270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35680">
        <property type="protein sequence ID" value="AYE35680"/>
        <property type="gene ID" value="CP523_15270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="214" mass="24916" checksum="16201A8BAFD00580" modified="2018-12-05" version="1">MSKRNWEKGTAQPIPNSKYTRFKETLREHSEVNSERNIMLFILARATGYRMQDLVCLTIKDIKLALKAGEFNIQEQKQYKQWVSNLKNYPNRKKPEKRKAEIGPKLERYLMNYVKNKKDSDFAFESKKGNRNEFITQKSYSLILSEVGKKIGLKNISGHSPRKTYATKIYEESNFNVEKVRVALGHKSIEETKRYLGLKEAMKSDAARIADEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ6</accession>
    <name>A0A386PIQ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05660</name>
        <name evidence="2" type="ORF">EI377_00095</name>
        <name evidence="3" type="ORF">EI377_16170</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33989">
        <property type="protein sequence ID" value="AYE33989"/>
        <property type="gene ID" value="CP523_05660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59353">
        <property type="protein sequence ID" value="QAS59353"/>
        <property type="gene ID" value="EI377_00095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62129">
        <property type="protein sequence ID" value="QAS62129"/>
        <property type="gene ID" value="EI377_16170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="19270" checksum="EE80FA73C4D2FDEA" modified="2018-12-05" version="1">MLKVFKHEETKKENIEFDIYTPINIEFGVWNISKEPTIYWRTGDFSGSLIEIGIGQYKKDVRSITLTICKNVYEVDNYYEDNFNIVKGSPILELENINNEIYTDENGILKVYIESKSVSIIFSENEISNCLQNHNVNFYLDANKSLVGLRVNNISEENKAILKDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT5</accession>
    <name>A0A386PIT5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ORF">CP523_09000</name>
        <name evidence="13" type="ORF">EI377_03745</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678356.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00240"/>
    <dbReference type="EnsemblBacteria" id="AYE34546">
        <property type="protein sequence ID" value="AYE34546"/>
        <property type="gene ID" value="CP523_09000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59946">
        <property type="protein sequence ID" value="QAS59946"/>
        <property type="gene ID" value="EI377_03745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="111" mass="12431" checksum="46D8E9D0DA1904A1" modified="2018-12-05" version="1">MEARAIAKYVRMSPMKVGVVLDLIRGKNIQEAFAILQYTPKDAAVVINKVLKSAVANAENNHEMDVERLYVADAFVGQGPTLKRFRPHAQGRAFRINKKTSHITLVVKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU9</accession>
    <name>A0A386PIU9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05930</name>
        <name evidence="6" type="ORF">EI377_00415</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01889"/>
    <dbReference type="EnsemblBacteria" id="AYE34039">
        <property type="protein sequence ID" value="AYE34039"/>
        <property type="gene ID" value="CP523_05930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59411">
        <property type="protein sequence ID" value="QAS59411"/>
        <property type="gene ID" value="EI377_00415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="23642" checksum="E8B8A3187CE4B56F" modified="2018-12-05" version="1">MITLNNVNKKFGDTEILKNININLEKNKIYGFEGKNGSGKTVLFKMICGFIAPSSGKILINNKQIGKDIDFPEKCGILIESPGFIDRFSAYKNLKLLADINRTISDSEIKKWMDFYDLEFNSKKKVKNFSLGMKQKLGLIQAFMEEPNILILDEPMNALDEKSVIKTRELLNSLKNNTIILISSHNKEDIESLCDEIFLIDNGIITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIV0</accession>
    <name>A0A386PIV0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Zinc transporter ZupT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">zupT</name>
        <name evidence="13" type="ORF">CP523_12190</name>
        <name evidence="14" type="ORF">EI377_07010</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mediates zinc uptake. May also transport other divalent cations.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673563.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35114">
        <property type="protein sequence ID" value="AYE35114"/>
        <property type="gene ID" value="CP523_12190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60505">
        <property type="protein sequence ID" value="QAS60505"/>
        <property type="gene ID" value="EI377_07010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00548">
        <property type="entry name" value="ZupT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023498">
        <property type="entry name" value="Zn_transptr_ZupT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="273" mass="29662" checksum="F9CB81FB7C5567A2" modified="2018-12-05" version="1">MDNVLVAFLITLFAGLATGIGSCIAFFVKKTNKKFLSISLGFSAGVMIYVSMVEIMSEAKRALVAEIGEKNGSLITVLSFFLGMLLIALIDKLVPSFENPHEVRNIENIENKSILNKDDINRDNKLLRMGVFTALVIGIHNFPEGLATFISALGDMKIAIPIAIAIAIHNIPEGISISVPIYYATGDKKKAFIYSFLSGMSEPLGALVGYIFLKNIFNDIIFGVVFAAVAGIMVFISLDELLPAAKEYGEHHLSIYGLISGMFVMAISLILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIV8</accession>
    <name>A0A386PIV8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13480</name>
        <name evidence="2" type="ORF">EI377_08380</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677577.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00793"/>
    <dbReference type="EnsemblBacteria" id="AYE35357">
        <property type="protein sequence ID" value="AYE35357"/>
        <property type="gene ID" value="CP523_13480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60748">
        <property type="protein sequence ID" value="QAS60748"/>
        <property type="gene ID" value="EI377_08380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="131" mass="15403" checksum="6BEA40EDF7299071" modified="2018-12-05" version="1">MNITEILNILDENNLSEIEELRSEEDLLLVKFYFDFDEDVLNAAKAYANEESDYEFESIEWIKEYFIPYLYDFANDEVLSIIEEIVDELDVSGEIMAFQMDSNNSNYVQFMALFTNGLDDITIEEVVKDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW6</accession>
    <name>A0A386PIW6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="7">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpA</name>
        <name evidence="11" type="ORF">CP523_12010</name>
        <name evidence="12" type="ORF">EI377_06830</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673471.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02959"/>
    <dbReference type="EnsemblBacteria" id="AYE35081">
        <property type="protein sequence ID" value="AYE35081"/>
        <property type="gene ID" value="CP523_12010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60474">
        <property type="protein sequence ID" value="QAS60474"/>
        <property type="gene ID" value="EI377_06830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="10">
        <location>
            <begin position="84"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="8">
        <location>
            <begin position="212"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="232"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="592" mass="65169" checksum="5DD8CCDE3080DB83" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX1</accession>
    <name>A0A386PIX1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675363.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02043"/>
    <dbReference type="EnsemblBacteria" id="AYE35144">
        <property type="protein sequence ID" value="AYE35144"/>
        <property type="gene ID" value="CP523_12345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="217" mass="25404" checksum="853579F62F2FCE26" modified="2018-12-05" version="1">MNNLPYFLDTCPDYIKDKFININFNTFDKILIQNQVADSVYIIRNGKVKVYSLTPTGVKHLERTYCENDLFGELELFVEKPILNYVEALEPCEAIKVSKESFLEWIKHDSDFSLYVHIQLSEKMYHTSINSKANVAYHLKYRLLFFLWKFLNEHNLDTVHKDILVEGVGSNIRSVNRIIKELVNENLIEYNKGFVKVKDINKIVDTIFSSNNNLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX9</accession>
    <name>A0A386PIX9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_12120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02981"/>
    <dbReference type="EnsemblBacteria" id="AYE35101">
        <property type="protein sequence ID" value="AYE35101"/>
        <property type="gene ID" value="CP523_12120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="123"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="380" mass="43622" checksum="60847AE850FC827D" modified="2018-12-05" version="1">MSNLCGNKLFNNEESESFINLLDDYILIINRKGEILYSNKSILKRVGYSIKDTYGKNILKKINRLEKKISLELYSKNNEKINFIGYILEGVWNEEISYTLILKEAIEEDSNEIENIKSELFANVSHEFKTPLNIILATMQLINNKIDTKKINLDNEVNLKKYMNTIKQNSYRLLRLVNNLIDKSKIQSGYYELDLGNHDIVNIVEDITLSIAPFVESKGINLVFDTDIEELIICCDPDKIERIMLNLLSNAVKYTENKGEIRVDLKSSEDKVTISIKDNGIGIPENELGYIFDRFRRVDNEYSKKVLGSGIGLTLVKLLVDMHGGEVHVKSKIGEGSEFSFELPKKVLKDDCNKKESKNLTSCRVEKCNIEFADIYNYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY1</accession>
    <name>A0A386PIY1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_04745</name>
        <name evidence="10" type="ORF">EI377_15255</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01723"/>
    <dbReference type="EnsemblBacteria" id="AYE35820">
        <property type="protein sequence ID" value="AYE35820"/>
        <property type="gene ID" value="CP523_04745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62239">
        <property type="protein sequence ID" value="QAS62239"/>
        <property type="gene ID" value="EI377_15255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS62239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="228" mass="26366" checksum="30DE3C0E09009F34" modified="2018-12-05" version="1">MKKILIVEDELFMREELQYILEKEGYDTFCITKFSNPIDEIIAASPDLVLLDLNLPRISGFEICKGIRQKSNVPILVLTGRDQMKDELHALDIGADEYINKPCHKERLLARITNLLRRLDDRKNFVEIKDISLDLQTYTINVKGKAMILPDNQGKIMKLLLENYPKLVTKEMLFKSLWGTTEYIDENALHVNMTRLKKSLHNLDTHYKISTIRGKGYSLEPIGDKSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY9</accession>
    <name>A0A386PIY9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprF</name>
        <name evidence="7" type="ORF">CP523_06245</name>
        <name evidence="8" type="ORF">EI377_00720</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00019"/>
    <dbReference type="EnsemblBacteria" id="AYE34099">
        <property type="protein sequence ID" value="AYE34099"/>
        <property type="gene ID" value="CP523_06245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59466">
        <property type="protein sequence ID" value="QAS59466"/>
        <property type="gene ID" value="EI377_00720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="344" mass="38688" checksum="D2E179EE211AE378" modified="2018-12-05" version="1">MSQYINKKKTSLYLLVLIVITFFIYLTIFKNQDFSKIAEVIASANPIIIICATSLIILFIFCEAFNINLLLNSMNYNISFLNSIKYAITGFFYSSITPSSTGGQPMQLYKMKRDGINLSHGTLVLLVELACFQTVTLILGGTSLIWASMTNIQITSFIKFLAVLGFFINILIVISIWISIFSKSFSEKVYGFICFLVNKLFFISEIKKEKIIYSLKSSLKKYNECAEFLKKQPILFLKCLSITTIQVVGLFSIPYVVYLALNEKGTSFISMFIIQSIVYLASSFIPMPGAAGISENNYISLFSKIYPIGVLNSAVLLTRVVNFYLPLIITFIALLGIEIASKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ24</accession>
    <name>A0A386PJ24_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14330</name>
        <name evidence="3" type="ORF">EI377_09240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02456"/>
    <dbReference type="EnsemblBacteria" id="AYE35880">
        <property type="protein sequence ID" value="AYE35880"/>
        <property type="gene ID" value="CP523_14330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62192">
        <property type="protein sequence ID" value="QAS62192"/>
        <property type="gene ID" value="EI377_09240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="1">
        <location>
            <begin position="212"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="374" mass="42844" checksum="5AEBC00551F3EF04" modified="2018-12-05" version="1">MLITLISSPVSKVIAYTEKESSSFTKDEIKTLESSSGTGTSEKVKAEFKGLLEKLFSERNEAVVCGDCELLKNFYDLNIKVSLWAYESEAKKTQYLINWSEKQYVQFKDLKSNVKIRKVVEKEPGLFGIICDVATDFNYYYLDSPDVINHFRLGTNHYINLKKNGDKYIITKEWYTDPFADSLDMDNIKSDEIKDYIISRNAPEFNPNERLQNAINYAHKYCGVSEDEEFTFKYNSKYKNHNPDGGDCANFASQILHEGGNFKKNGAWNYDGKDGTKAWLNAQGFKNYMLGSGRASYIAKGNYNKVYKAAFNMRPGDFVAYEKKGRITHISTVTGFDSKGYPLVTCHNTDRLLVPYDLGWSNSNIKFHLIHVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ28</accession>
    <name>A0A386PJ28_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00224"/>
    <dbReference type="EnsemblBacteria" id="AYE35457">
        <property type="protein sequence ID" value="AYE35457"/>
        <property type="gene ID" value="CP523_14035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017413057" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="POLIIIAc" evidence="2">
        <location>
            <begin position="584"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131062" checksum="84BB6AF3257B9CA5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ73</accession>
    <name>A0A386PJ73_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676684.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02624"/>
    <dbReference type="EnsemblBacteria" id="AYE34656">
        <property type="protein sequence ID" value="AYE34656"/>
        <property type="gene ID" value="CP523_09590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="318" mass="34767" checksum="5527819374C1B290" modified="2018-12-05" version="1">MYYLGIDGGGTKTRYILINDKLEKVGDCESGTIHIHQVGVDGIKKELKENISKLCSNINIDPKDISFAFAGVPGYGESLEDKVKIDKAINEVMECPYMIDNDAVNGWAAGTACKPGINMVAGTGSIAYGRNSKGKLARCGGFGPGIGDDGSAYWIGLRTINEYTKQKDGRKEKTALVDVLEKEYNISYDYEIVDIVFNRLERDRTKLAGFSKICFLAAEKGCPVAVKIFEDVAEELFKHINSLSKTLGFDGKFVVSYTGGVFKAGKYVLEPLKKRVLEAGLDCIIQEPELDPWNGAALLAYNLAGNEVPSNIKEIMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE5</accession>
    <name>A0A386PJE5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Type 1 glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13520</name>
        <name evidence="3" type="ORF">EI377_08420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677588.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00800"/>
    <dbReference type="EnsemblBacteria" id="AYE35364">
        <property type="protein sequence ID" value="AYE35364"/>
        <property type="gene ID" value="CP523_13520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60755">
        <property type="protein sequence ID" value="QAS60755"/>
        <property type="gene ID" value="EI377_08420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="22200" checksum="EE4697DC9D1EC0FE" modified="2018-12-05" version="1">MLLMLDNYDSFVFNLVRYIEELGEEVIIYRNNKITIEEIEKLKVNGIIISPGPKSPKEAGRSLEIIDYFKGKIPILGICLGHQCIGDYFGGDIIKGKEPVHGKMSMVTHSNSGIFKGIKNPLRVTRYHSLILDKNTLPNELEVSCETDDGIIMGVNHKNYPIFGVQFHPEAEMTEEGHNLLNNFLNITREFKGESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJK4</accession>
    <name>A0A386PJK4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_10740</name>
        <name evidence="7" type="ORF">EI377_05525</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674109.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01354"/>
    <dbReference type="EnsemblBacteria" id="AYE34842">
        <property type="protein sequence ID" value="AYE34842"/>
        <property type="gene ID" value="CP523_10740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60236">
        <property type="protein sequence ID" value="QAS60236"/>
        <property type="gene ID" value="EI377_05525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="346" mass="38723" checksum="776AF3C2486C91FE" modified="2018-12-05" version="1">MKDRPIITVKNLKTYFYTNQRCNKAINGVSFQIKKGKTLCVVGESGCGKSVTASSIMQLLPKLSRIEEGEIIYHGDKGDIRIDKLARNGKEMRGLRGKDIAMIFQDPMTALNPVYTVGYQIAENILCHEKVSKKDAKARTLELLKDMGIPFPEQRINEYPHQFSGGMRQRAMIAMAMSCNPNVLIADEPTTALDVTIQAQIFELMDKLKKENDTAILLITHDMGVVSELADEVAVMYMGNIIESGSVEEILRTPAHPYTEALLKSIPVLGKGKDQELNPIKGSTPDPYDRPIGCQFAPRCNYACDKCKKMPVEELIGENHMVRCFRHEEVLKNNLKKNEEVMASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN5</accession>
    <name>A0A386PJN5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08210</name>
        <name evidence="2" type="ORF">EI377_02960</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674701.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34409">
        <property type="protein sequence ID" value="AYE34409"/>
        <property type="gene ID" value="CP523_08210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59814">
        <property type="protein sequence ID" value="QAS59814"/>
        <property type="gene ID" value="EI377_02960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="7027" checksum="76172F9C1CBA29FA" modified="2018-12-05" version="1">MKEANLKLAQQDIDEALKTVEDMEKVINETEVPNNLLREKFLTLTEKVQKLESILKTEGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK47</accession>
    <name>A0A386PK47_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09265</name>
        <name evidence="3" type="ORF">EI377_04010</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678313.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03045"/>
    <dbReference type="EnsemblBacteria" id="AYE34599">
        <property type="protein sequence ID" value="AYE34599"/>
        <property type="gene ID" value="CP523_09265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59999">
        <property type="protein sequence ID" value="QAS59999"/>
        <property type="gene ID" value="EI377_04010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="416" mass="45989" checksum="CDF509EA058453D7" modified="2018-12-05" version="1">MDKRDKNKRGIVPVICLLLSIGLWFYVTNVENPRRSYELKDVPVEIYNAETLVDSKLALVPDQKFYVNLKLEGYGSDIYKIKESDFKITVDLSDYALKKGENKIPVSIEKSPANINIKNDSSLTISIMLEELVEKSFQIKPRISITTKSGFFASEPDINPQEIQVSGAQSLVNRVSSIVVTGEEHDVSSDVKSSYKLEPLDSADKLVEGVHLSQDVVDVVIKISQGKSVPLKINTVGQLPAGMKLKTLEATRKTVELLGPKDLLDKITEVQSTPLDLSTFNGDGETNLTVVIPEGLSIKQGEEYVNVKLTVSKIVSKNFEVAFTLKGALEGLKITPTKNTVKVSISGYDDEIENVTVDNIKAELNVESFKDEGTFSVSPIVTLIGLDEKFTIGNIEKIEFTVVKEVEQKPEENIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKB1</accession>
    <name>A0A386PKB1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine synthase</fullName>
            <ecNumber evidence="6">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CP523_12040</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673482.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02965"/>
    <dbReference type="EnsemblBacteria" id="AYE35086">
        <property type="protein sequence ID" value="AYE35086"/>
        <property type="gene ID" value="CP523_12040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12040"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017215">
        <property type="entry name" value="MetH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037472">
        <property type="entry name" value="DHPS_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 19 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 19 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="20">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="21">
        <location>
            <begin position="312"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="23">
        <location>
            <begin position="574"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="22">
        <location>
            <begin position="669"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="AYE35086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="795" mass="87270" checksum="3408E2ABD37A2B4D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKD1</accession>
    <name>A0A386PKD1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15530</name>
        <name evidence="3" type="ORF">EI377_10240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678703.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35731">
        <property type="protein sequence ID" value="AYE35731"/>
        <property type="gene ID" value="CP523_15530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61070">
        <property type="protein sequence ID" value="QAS61070"/>
        <property type="gene ID" value="EI377_10240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="127" mass="14503" checksum="A94694EA067CC8B2" modified="2018-12-05" version="1">MIRIDARSSTPIYEQIIIKIKELILKGIIKPGEKLPSVRELSSIITANPNTVSKAYGELERDGVIESLRGRGTFVVEDYKPIFSDKKFEKIKEELKKIMLEAKYLGLKKEDLIKALNECFNDMEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKK3</accession>
    <name>A0A386PKK3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12555</name>
        <name evidence="4" type="ORF">EI377_07445</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675269.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02002"/>
    <dbReference type="EnsemblBacteria" id="AYE35186">
        <property type="protein sequence ID" value="AYE35186"/>
        <property type="gene ID" value="CP523_12555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60589">
        <property type="protein sequence ID" value="QAS60589"/>
        <property type="gene ID" value="EI377_07445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033789551" evidence="1">
        <location>
            <begin position="29"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="53"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="255" mass="29558" checksum="EF747790DA230C53" modified="2018-12-05" version="1">MKNKLKCFLFLSVNILLIISIFTQSINAVPMSGEATSTEENDINENEKIPFKKEVYLTFDDGPSCRVTDNVLDILKENDVKATFFLIGNQIMGKEEVVKRINAEGHSIGLHTFNHKFKYVYSSEDKFIEEMNDCREEINRVVGISPSIIRFPGGSYKHLSKKYLKRLHENDFKVYDWNVDSTDGMNPNLPADKIYRKAIKVNKDSKPTIILMHCTDLQKNTPKALPEIIKYYKDKGYEFKTITEDTKEMYFNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKL1</accession>
    <name>A0A386PKL1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10515</name>
        <name evidence="4" type="ORF">EI377_05300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674197.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01397"/>
    <dbReference type="EnsemblBacteria" id="AYE34799">
        <property type="protein sequence ID" value="AYE34799"/>
        <property type="gene ID" value="CP523_10515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60194">
        <property type="protein sequence ID" value="QAS60194"/>
        <property type="gene ID" value="EI377_05300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362787" evidence="1">
        <location>
            <begin position="24"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="77"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="33818" checksum="A148F59A76CED4BF" modified="2018-12-05" version="1">MSRKNIISIILIICMAVSCTSCANKGSSKEEGLIKPIAIKGESIKSIGDKTRQINEEIRDIVGDDIDRMGLYYYDIKTGENIAINEDKVFRAASTTKVDLAMMVMDAMNRGELSPNDTFSYVEELDYEDGTGILQDLETIKPLTVMELIKLSIVYSDNIATNMLYRTTPYNRSDYIYKVTGIPCKKEINESTPKQQFLMLKKLYENNEKNPYYDKLIEFMKETEFHDRIDKDIPWEICAHKIGNNDMYIHDIGIIYTENPYILVVYTEDLGNEEYAMNVISDISKKIYEINQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP1</accession>
    <name>A0A386PKP1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YVTN family beta-propeller protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">YncE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14460</name>
        <name evidence="2" type="ORF">EI377_09435</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676828.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02485"/>
    <dbReference type="EnsemblBacteria" id="AYE35538">
        <property type="protein sequence ID" value="AYE35538"/>
        <property type="gene ID" value="CP523_14460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60925">
        <property type="protein sequence ID" value="QAS60925"/>
        <property type="gene ID" value="EI377_09435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="292" mass="32762" checksum="E41002C006755565" modified="2018-12-05" version="1">MNSILVCNTGSDSISKVNISDLTVENLPLDFGEKPIGPHGIYISDKKIYTANNYSNSVSIINGVTFKEEDSIYIGPYPNDVATLKNKLYISCGESNAIIVYDLVEKKILFEIPIDKWPHSIEIYKEAEMIFVSNLEGNSISIIDGIDNKVIKKIDTLEYPTKILVSKDKSKIYVCESYIGEDTFGYVEVFSIKNLCTLKRIKVGKSPVDMWDDGNFLYVSNFSDGTISIIDVDTLKEIKRINVGSMPKGIIRYKDKLYIGDYLKGRILSLNLKTKETKAIAVGKEPNAMTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKX4</accession>
    <name>A0A386PKX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15130</name>
        <name evidence="3" type="ORF">EI377_10085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679009.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35658">
        <property type="protein sequence ID" value="AYE35658"/>
        <property type="gene ID" value="CP523_15130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61044">
        <property type="protein sequence ID" value="QAS61044"/>
        <property type="gene ID" value="EI377_10085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="145" mass="17014" checksum="AEEE4EB3EC5690B4" modified="2018-12-05" version="1">MRYSVDAKYTKVENGIKTIFMNCTLILTMLIILNLVSIFLFKKQVMSWIYIVFFSIIYGQLWNLSNKKVIATIPFKIDENTLIKILKRNKLKFEVNSEKIIKIKMDFVATMIKLDLIIRILDNKVEIEGAKYMVENIIGKIENIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLF3</accession>
    <name>A0A386PLF3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>unnamed1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
            <plasmid evidence="3">unnamed1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023672">
        <property type="protein sequence ID" value="AYE35898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35898">
        <property type="protein sequence ID" value="AYE35898"/>
        <property type="gene ID" value="CP523_15805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Plasmid unnamed1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="168" mass="19839" checksum="986ACB14987C3CCC" modified="2018-12-05" version="1">MYDIKQVSELTGVSKVTIYKKIKKLKDLGPFIVHKGDKTYILEDGLRLIKENLTVNKKVKLEVESELAIEDISMDLTINKELINLLTEQLKEKDTQLKEKDKQIAELHKLIENSQILLKEEQKKNDNQIYLADHFEEVDNKLQDIREKMEQKRSDKKYKNGFFKIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLH0</accession>
    <name>A0A386PLH0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14905</name>
        <name evidence="6" type="ORF">EI377_09860</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676076.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01302"/>
    <dbReference type="EnsemblBacteria" id="AYE35616">
        <property type="protein sequence ID" value="AYE35616"/>
        <property type="gene ID" value="CP523_14905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61003">
        <property type="protein sequence ID" value="QAS61003"/>
        <property type="gene ID" value="EI377_09860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="24905" checksum="2E55D9E3A2AE4294" modified="2018-12-05" version="1">MEIEDKVKSIMKNISRDVLLLAVSKTKPLEDLEKAYKSGIRDFGENKVQELIAKEEVFHKDVRWHFIGNLQVNKVKYLVGKVTLIHSLSSLKLLEKIENEFSKKNLVANTLIQINIGREESKGGVLIEELDNMIEAVEKCNFVKVKGIMVIIPKGNDKSNRIYFKETKKIFNSIKQNKYKNISMEILSMGMTNDYEIAIEEGSNLVRIGSGIFGKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLJ5</accession>
    <name>A0A386PLJ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13280</name>
        <name evidence="2" type="ORF">EI377_08140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679042.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35319">
        <property type="protein sequence ID" value="AYE35319"/>
        <property type="gene ID" value="CP523_13280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60707">
        <property type="protein sequence ID" value="QAS60707"/>
        <property type="gene ID" value="EI377_08140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008841">
        <property type="entry name" value="Siphovirus-type_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05709">
        <property type="entry name" value="Sipho_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="27330" checksum="58E55E355A0915BE" modified="2018-12-05" version="1">MYGFTINDRHSYNDFGLRIMNREINPPKKNKIKERVPFMNGSYDFSDLYGDQNYEERIIVYTLDFKYKDKIEYFNKKIEISDWLVNSEKEKLFDDLIPGYYFLAECEGDLKFKEYSVGCEINVKFIAYPFKIANNIEGSDIWDEFNFELDYAQDTKYNVDGSKIIDIYNPSVIKITPTIHCSAPISLIKNGITYKFNVGTTKDWRFDLDKGKNKLTIIGNGNIEFIFRKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLN2</accession>
    <name>A0A386PLN2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore coat</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CotF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678737.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03065"/>
    <dbReference type="EnsemblBacteria" id="AYE35706">
        <property type="protein sequence ID" value="AYE35706"/>
        <property type="gene ID" value="CP523_15400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012851">
        <property type="entry name" value="Spore_coat_CotF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39183">
        <property type="entry name" value="PTHR39183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07875">
        <property type="entry name" value="Coat_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="99" mass="10950" checksum="A788E3851C5D18DB" modified="2018-12-05" version="1">MKNIIGNMIKNNIDINDEFIALSMLSSGKEASDMYLNSTLTSSTPELRAIYSASLGQIVEGHTALTELSVNKGWIKPYNTSEEQLTCSYNESKSIINEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLP6</accession>
    <name>A0A386PLP6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15505</name>
        <name evidence="2" type="ORF">EI377_10210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678711.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35726">
        <property type="protein sequence ID" value="AYE35726"/>
        <property type="gene ID" value="CP523_15505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61065">
        <property type="protein sequence ID" value="QAS61065"/>
        <property type="gene ID" value="EI377_10210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="7353" checksum="1DE3754D7D0F3B59" modified="2018-12-05" version="1">MEIEKEKIIEIWNSDHNKVTKYTQIIKNNSINEFKKIEAKSLSSLMNKVRDQVIEWNFNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAN2</accession>
    <name>A0A386PAN2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_00215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677383.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01189"/>
    <dbReference type="EnsemblBacteria" id="AYE32983">
        <property type="protein sequence ID" value="AYE32983"/>
        <property type="gene ID" value="CP523_00215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="319"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="580"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="640" mass="74324" checksum="C3FBC1E7D2B1FDF5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB27</accession>
    <name>A0A386PB27_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">CP523_00955</name>
        <name evidence="12" type="ORF">EI377_11450</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674526.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02328"/>
    <dbReference type="EnsemblBacteria" id="AYE33123">
        <property type="protein sequence ID" value="AYE33123"/>
        <property type="gene ID" value="CP523_00955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61293">
        <property type="protein sequence ID" value="QAS61293"/>
        <property type="gene ID" value="EI377_11450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="308" mass="34238" checksum="6ADE623C5DDFD5A2" modified="2018-12-05" version="1">MKIVFMGTPDFSVPSLKKLIETYGVQSVFTQPDKPKGRGKKMTFSPVKEVALENNIPVYQPIKLKDDRECIEYLKELKPDFIIVVAFGQILTKEVLDIPRYGCINLHASLLPMYRGAAPLNWVIINGENKSGNTTMLMDVGLDTGDMLLKNEVDITEDMTAGELHDILMSTGADLLIDTIEGLVDGSIVPKKQEGETFYAKMLNKELGQINWNNSAKNINNLIRGLNPWPIAHTKYESQPMKIYSSSVLNENSSKTPGTILNVTKQGIKVATSDGVLLIRKVQFPNGKPLTIEQYINGNEIKENIILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBB7</accession>
    <name>A0A386PBB7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cobalt transport protein CbiM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Energy-coupling factor transporter probable substrate-capture protein CbiM</fullName>
            <shortName evidence="11">ECF transporter S component CbiM</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cbiM</name>
        <name evidence="12" type="ORF">CP523_01440</name>
        <name evidence="13" type="ORF">EI377_11960</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CbiM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675611.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00840"/>
    <dbReference type="EnsemblBacteria" id="AYE33215">
        <property type="protein sequence ID" value="AYE33215"/>
        <property type="gene ID" value="CP523_01440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61387">
        <property type="protein sequence ID" value="QAS61387"/>
        <property type="gene ID" value="EI377_11960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01440"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01462">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018024">
        <property type="entry name" value="CbiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43627">
        <property type="entry name" value="PTHR43627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00123">
        <property type="entry name" value="cbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 11" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="241" mass="25890" checksum="89E4F8649ABA35EA" modified="2018-12-05" version="1">MKKSGFLVFTLLLSISIPFNAYAMHIAEGYLALNWCIFYFILSAPFIILSIKELRKTIKRNSDIKMLLALMGAYVFMMSALKLPSVTGSSSHPTGTGLGAVVFGPMVMVVISAVVLLFQALLLAHGGLTTLGANVLSMGIVGPFVAYFIYRLFKKKNESVAVFLACALGNLLTYVVTSIQLALAFPSADGGVIVSAVKFLGVFAVTQVPLAIVEGIVSVVIFDFIKKHCRQELSELEGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC45</accession>
    <name>A0A386PC45_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamylcyclotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03055</name>
        <name evidence="3" type="ORF">EI377_13555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678429.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01766"/>
    <dbReference type="EnsemblBacteria" id="AYE33515">
        <property type="protein sequence ID" value="AYE33515"/>
        <property type="gene ID" value="CP523_03055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61681">
        <property type="protein sequence ID" value="QAS61681"/>
        <property type="gene ID" value="EI377_13555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GGACT" evidence="1">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="145" mass="17074" checksum="28EADBC768483FE8" modified="2018-12-05" version="1">MLENKEIKIFVYGSLREGFFNYDRYLKGNVIENKPAKMNNFILYHMPYKGYPAVIDGNGEVYGEVMTLSNYDEVMNSVDEMEGFISKGNPNNEYNKELVEVLYEDGTKELCYSYIYNKELDVNFNEEAIFIDNGNWKEYQQKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCA1</accession>
    <name>A0A386PCA1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02450</name>
        <name evidence="2" type="ORF">EI377_12975</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673959.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00477"/>
    <dbReference type="EnsemblBacteria" id="AYE33400">
        <property type="protein sequence ID" value="AYE33400"/>
        <property type="gene ID" value="CP523_02450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61574">
        <property type="protein sequence ID" value="QAS61574"/>
        <property type="gene ID" value="EI377_12975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="15686" checksum="3E50C00960C285C9" modified="2018-12-05" version="1">MGFKDKMTKYFSDAYLEKYGDRMTSASGTVLSVKLEEKNILGIFRILKVNLIVKSDIGKGVVKALYKKNRWFKKPEFIDIKQGHKVIIMGISGEKGKENSDVIIASNVANLSTKKDLFPFDHSQLKKARQQATKMRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCX7</accession>
    <name>A0A386PCX7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02100</name>
        <name evidence="3" type="ORF">EI377_12620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 8 (cellulase D) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00546"/>
    <dbReference type="EnsemblBacteria" id="AYE33337">
        <property type="protein sequence ID" value="AYE33337"/>
        <property type="gene ID" value="CP523_02100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61507">
        <property type="protein sequence ID" value="QAS61507"/>
        <property type="gene ID" value="EI377_12620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002037">
        <property type="entry name" value="Glyco_hydro_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01270">
        <property type="entry name" value="Glyco_hydro_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="373" mass="43242" checksum="817CA56C1336C830" modified="2018-12-05" version="1">MKKRKILIVLALIIFIILGVGINFSMEYLKPIKVEPVLSKEVYTNEEEILLKFLQNNLMDSEGGVYTNLKDKENEGDITKGHSILSESQGILLMYYLYSGDEENFERIFNYIKNKMILDNNLISWRIENGEPSKVSATIDDLRIAKALILASKEFNNFKYRYYGVNISQGIYENLVHNENLIDFKDEFGKSKESTLCYLDLPAIKLLSQIDNKWRKIYDNSLKIINGGLISEDLPLYRKKYNTNDKLYDNEEVDSLLSMLVILNKSEAGEDVSKSIEWIKNQLKEKGYISSLYNIETGEESKIESTSIYSNIVEIAKVIGDRELYELAFNKMKIFQVNNKDSKIYGAFGDEKSEMVYSYDNLNSLLSFRRNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD46</accession>
    <name>A0A386PD46_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4 11">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ahpC</name>
        <name evidence="13" type="ORF">CP523_05195</name>
        <name evidence="14" type="ORF">EI377_15755</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4 11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676233.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01828"/>
    <dbReference type="EnsemblBacteria" id="AYE33913">
        <property type="protein sequence ID" value="AYE33913"/>
        <property type="gene ID" value="CP523_05195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62064">
        <property type="protein sequence ID" value="QAS62064"/>
        <property type="gene ID" value="EI377_15755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03137">
        <property type="entry name" value="AhpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS62064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="187" mass="20725" checksum="FD2BA1C16D8EFC45" modified="2018-12-05" version="1">MSLIGKQIPEFKVEAYHNGDFTEVTTSDVKGKWGVFFFYPADFTFVCPTELGDLADNYEKFKEIGCEVYSVSTDTHFVHKAWADASETIAKIQYPMLGDPTGNLTRGFDVMIEEEGLALRGTFIVNPEGEIKAYEVHDLGIGRNAEELLRKVQAAQFVAEHGDQVCPAKWTPGAETLVPSLDLVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD86</accession>
    <name>A0A386PD86_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">mutS</name>
        <name evidence="11" type="ORF">CP523_00145</name>
        <name evidence="12" type="ORF">EI377_10750</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677402.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01203"/>
    <dbReference type="EnsemblBacteria" id="AYE32971">
        <property type="protein sequence ID" value="AYE32971"/>
        <property type="gene ID" value="CP523_00145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61161">
        <property type="protein sequence ID" value="QAS61161"/>
        <property type="gene ID" value="EI377_10750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="613"/>
            <end position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE32971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="880" mass="99735" checksum="70E61B1B0D9CBCB7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD87</accession>
    <name>A0A386PD87_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_04365</name>
        <name evidence="12" type="ORF">EI377_14900</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00405"/>
    <dbReference type="EnsemblBacteria" id="AYE33760">
        <property type="protein sequence ID" value="AYE33760"/>
        <property type="gene ID" value="CP523_04365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61917">
        <property type="protein sequence ID" value="QAS61917"/>
        <property type="gene ID" value="EI377_14900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="227" mass="26317" checksum="F8E6DDBAA3FAC1D3" modified="2018-12-05" version="1">MIMKILIAEDKMEIANLVRIFLQKEGYEVILANDGEEALKILLNDKIDLCIFDIMMPKMDGFTLIQKTREFSRVPILVLTAKNMEQDKILGLDLGADDYITKPFSSLELVSRVNAHIRRSYKLNQLETITYIGDLKIDKEKYIVYKNDVDCTLTAMEYKLLLKLLSSPERVFTKSQLYESVCGNYMDGDENTIAVHISRLREKIEDNPKEPEYIKTIRGLGYKFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD98</accession>
    <name>A0A386PD98_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_02745</name>
        <name evidence="15" type="ORF">EI377_13270</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676962.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00955"/>
    <dbReference type="EnsemblBacteria" id="AYE33457">
        <property type="protein sequence ID" value="AYE33457"/>
        <property type="gene ID" value="CP523_02745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61628">
        <property type="protein sequence ID" value="QAS61628"/>
        <property type="gene ID" value="EI377_13270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037052">
        <property type="entry name" value="CheA-like_P2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035891">
        <property type="entry name" value="CheY-binding_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55052">
        <property type="entry name" value="SSF55052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="296"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="12">
        <location>
            <begin position="544"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="671" mass="75179" checksum="ECB81A50941F31F4" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDC9</accession>
    <name>A0A386PDC9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34003">
        <property type="protein sequence ID" value="AYE34003"/>
        <property type="gene ID" value="CP523_05745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="77" mass="8691" checksum="9E0369539006CF3F" modified="2018-12-05" version="1">MLLTLFRNKIPFAAPTTPSIGWLTNSKISFATPTSVSPIPNKNLIVTLFIVINSLFLFILSFQFFLFLSETLNFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDD8</accession>
    <name>A0A386PDD8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05795</name>
        <name evidence="4" type="ORF">EI377_00280</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674970.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34013">
        <property type="protein sequence ID" value="AYE34013"/>
        <property type="gene ID" value="CP523_05795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59385">
        <property type="protein sequence ID" value="QAS59385"/>
        <property type="gene ID" value="EI377_00280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="63" mass="7619" checksum="C60118795C2FEB8C" modified="2018-12-05" version="1">MISRIEKHGSKKNKQSTSIRQHRMKRLERNKLKKEKRSNKIRNMLLILSIIIIGVLIYYITNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDE9</accession>
    <name>A0A386PDE9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_05850</name>
        <name evidence="10" type="ORF">EI377_00335</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01873"/>
    <dbReference type="EnsemblBacteria" id="AYE34023">
        <property type="protein sequence ID" value="AYE34023"/>
        <property type="gene ID" value="CP523_05850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59395">
        <property type="protein sequence ID" value="QAS59395"/>
        <property type="gene ID" value="EI377_00335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00795">
        <property type="entry name" value="lctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="506" mass="53164" checksum="A284ADF498EE1EDD" modified="2018-12-05" version="1">MNEYLMFFIALLPIVLLIVSLGVFKIPGHKICPIALVLTIVLSIIGWKMPLGVSLSAALEGIVLALWPIMLVIIAAVFTYNLSVHTKGMETIKKILTSVTTDKRILVLILAWGFGGFLESVAGFGTAVAIPASILIVLGFDPIFAAIICLVANTTPTAFGAIGLPINTLSELANLTPTQLSNDVSIQLFLFVVFIPMALVMITGKSFKSVKGVLGITLVSGIAFAIPQAIFAKYLGAELPAVLGSVASLAVTIWMAKTFHKDKQAKNIDERVSFKSGVIAWSPFILILVLILLSSPLFPSINAALSSIKTSVHIYQGQDSIPYTFTWIGTPGVLILISGFIGGAIQGANFKEMLGVLGRTVKQMSKSGITILSIIALAKVMGYSGMIKSIAVILVMITGRFYPVIAPLIGALGTFITGSATSSNVLFGGLQVEAAKSLAIDPCWLAAANTAGATAGKIISPQSIAVATAATGIAGEEGKILNSTLKFFLAYVIIQGIITFFGAVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDL9</accession>
    <name>A0A386PDL9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">plsX</name>
        <name evidence="5" type="ORF">CP523_00845</name>
        <name evidence="6" type="ORF">EI377_11340</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674585.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02350"/>
    <dbReference type="EnsemblBacteria" id="AYE33101">
        <property type="protein sequence ID" value="AYE33101"/>
        <property type="gene ID" value="CP523_00845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61271">
        <property type="protein sequence ID" value="QAS61271"/>
        <property type="gene ID" value="EI377_11340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00845"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="333" mass="36480" checksum="1296C5BC38F2191A" modified="2018-12-05" version="1">MKIAIDGMGGDNAPKAVIEGLMLALKEYNGIEYYITGKAEEIEKELKNYDYDKNLVKVIDAREVISTNEHPVRALKRKKDSSICKALKLVKDKECDAVISAGSTGAFLAGCTLLVGRIKGVERPALAPIMPGKNGSFMIVDAGANVDSKPNYLVQFAHMGRIYYQEVIGTKNPTIGLVNIGAEEEKGNELTKAVHKLLKEEKDLNFVGNVEPRETSTGDVNVLVCDGFVGNTLLKMYEGVAKTLLTMIKEEILSSGFMSKIGAGLLKPVFKKLKIKFDYKEYGGAPFLGVDGICIKAHGSSDGKAFKNAIRQTKTFYDNEVLEKIKEELKNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDR4</accession>
    <name>A0A386PDR4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hyaluronoglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_03555</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02262"/>
    <dbReference type="EnsemblBacteria" id="AYE33607">
        <property type="protein sequence ID" value="AYE33607"/>
        <property type="gene ID" value="CP523_03555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017240658" evidence="9">
        <location>
            <begin position="33"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1794"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="637"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="1036"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="11">
        <location>
            <begin position="1789"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1740"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1430"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1626"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1752"/>
            <end position="1788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1820" mass="205423" checksum="1939A8BFDC688D9E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDX9</accession>
    <name>A0A386PDX9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06960</name>
        <name evidence="8" type="ORF">EI377_01445</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673653.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01007"/>
    <dbReference type="EnsemblBacteria" id="AYE34213">
        <property type="protein sequence ID" value="AYE34213"/>
        <property type="gene ID" value="CP523_06960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59578">
        <property type="protein sequence ID" value="QAS59578"/>
        <property type="gene ID" value="EI377_01445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="298" mass="33603" checksum="9DEE062270926EB7" modified="2018-12-05" version="1">MKKAFKEMSAEKLFRIFMYLCLSIFALSILIPLGWAFLASMKHKSEFYGNPWVLPQGFYFENFRKAFVEAHMGEYFINSIIVTGLALIILLVVAIPAAYVLSRFEFKSKKVINLLFSAGLFINVNYIVVPIFLMVLDGEKLVKEIFALPASMSLFLDSRIVVSIIYASTALPFTIYLLMNFLRTLPKAYEEAAYMDGCSNFKTLIHVIIPMAKPSILTVILFNFLAFWNEYIIALTMLPNGAKTLPLGLINLMQVQKTATDYGAMYAGLVIVMIPTIILYILVQKKLTEGMTVGGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE51</accession>
    <name>A0A386PE51_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07530</name>
        <name evidence="4" type="ORF">EI377_02220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34303">
        <property type="protein sequence ID" value="AYE34303"/>
        <property type="gene ID" value="CP523_07530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59697">
        <property type="protein sequence ID" value="QAS59697"/>
        <property type="gene ID" value="EI377_02220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="2">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="118" mass="14154" checksum="5D6C3BED30F59755" modified="2018-12-05" version="1">MDDKNIYNKFKMNKNKFIFDLMNSNSLKENSNNNPIINITENKNYYSIFISLNEFKKEEILLKYINNFLILNLNLRNKNNKSLKYKRLFYLKDIDICNITNKISANLIYLKVPKIVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE67</accession>
    <name>A0A386PE67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1292 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01145</name>
        <name evidence="3" type="ORF">EI377_11645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674416.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33158">
        <property type="protein sequence ID" value="AYE33158"/>
        <property type="gene ID" value="CP523_01145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61328">
        <property type="protein sequence ID" value="QAS61328"/>
        <property type="gene ID" value="EI377_11645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="91" mass="10533" checksum="91217AD61D371D11" modified="2018-12-05" version="1">MDKDLKQIELYDEDGNLVKLNIVAFFDMVNPDTEEKTEYVIVYDDEYTEDDIFALKVDKDEDGEDLLVPVDDEIELAAVQEAYDTIFSDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE82</accession>
    <name>A0A386PE82_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06365</name>
        <name evidence="3" type="ORF">EI377_00835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677784.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34120">
        <property type="protein sequence ID" value="AYE34120"/>
        <property type="gene ID" value="CP523_06365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59486">
        <property type="protein sequence ID" value="QAS59486"/>
        <property type="gene ID" value="EI377_00835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="140" mass="15170" checksum="60DC56C503B1CDE3" modified="2018-12-05" version="1">MENEKNNKVGAGILTVAIIQFVLSGFGILFLGLGLLFKDAINAQLKSMGNDPIPDGGQISIIISFIFMVLAIIGLILILRKKAIGIYLYFAVQVLDKIFGAITQGVNIIGLIVGLILPVLMAIFVYKKRALYGFENNLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE90</accession>
    <name>A0A386PE90_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate 1-decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartate alpha-decarboxylase</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="9">Aspartate 1-decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="9" type="primary">panD</name>
        <name evidence="14" type="ORF">CP523_07835</name>
        <name evidence="15" type="ORF">EI377_02525</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679148.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02100"/>
    <dbReference type="EnsemblBacteria" id="AYE34345">
        <property type="protein sequence ID" value="AYE34345"/>
        <property type="gene ID" value="CP523_07835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59741">
        <property type="protein sequence ID" value="QAS59741"/>
        <property type="gene ID" value="EI377_02525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07835"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5033995537" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033995536" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS59741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="128" mass="14461" checksum="32D94BCD757C0C53" modified="2018-12-05" version="1">MKLNMLKGKIHRATVIQAELDYVGSITIDEDLLDAAGILEYEMVQIVDINNGNRFETYTIAGERGTGMICLNGAAARCVQVNDKIIIMSYCQLDSNEVKDHKPRVIFVNNENRISRITRYEKHGKLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB7</accession>
    <name>A0A386PEB7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SanA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08025</name>
        <name evidence="4" type="ORF">EI377_02785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675934.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34375">
        <property type="protein sequence ID" value="AYE34375"/>
        <property type="gene ID" value="CP523_08025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59781">
        <property type="protein sequence ID" value="QAS59781"/>
        <property type="gene ID" value="EI377_02785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="53"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26617" checksum="EA686FEF78FEE3DE" modified="2018-12-05" version="1">MKKGFLRRIKKSMIIGIMLLIIILVGSMIAIIQNVQGYDKYIVKLEDLPRDIDSIIVLGAGVKNDGEPSDILIDRLETALKIYKEDKSDTFVLTGDHGKEDYNEVRAMKDYIMKHDINEKRVFMDHAGFSTYDSMYRAKEIFKVNKAIIVTNEYHLPRALYIARKLGIEAYGIPSDIREYLFIDSYKTREKLAQLKDFIYVNVLKPKPEFLGDEIPVNSSDGRLTDDEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM5</accession>
    <name>A0A386PEM5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha,alpha-phosphotrehalase</fullName>
            <ecNumber evidence="4">3.2.1.93</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">treC</name>
        <name evidence="3" type="ORF">CP523_07255</name>
        <name evidence="4" type="ORF">EI377_02010</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.93" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673746.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01068"/>
    <dbReference type="EnsemblBacteria" id="AYE34260">
        <property type="protein sequence ID" value="AYE34260"/>
        <property type="gene ID" value="CP523_07255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59667">
        <property type="protein sequence ID" value="QAS59667"/>
        <property type="gene ID" value="EI377_02010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008788">
        <property type="term" value="F:alpha,alpha-phosphotrehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012769">
        <property type="entry name" value="Trehalose_TreC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02403">
        <property type="entry name" value="trehalose_treC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="11"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="552" mass="65079" checksum="66407EEADC6E32C0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER1</accession>
    <name>A0A386PER1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">CP523_08945</name>
        <name evidence="11" type="ORF">EI377_03700</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678844.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01788"/>
    <dbReference type="EnsemblBacteria" id="AYE34535">
        <property type="protein sequence ID" value="AYE34535"/>
        <property type="gene ID" value="CP523_08945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59937">
        <property type="protein sequence ID" value="QAS59937"/>
        <property type="gene ID" value="EI377_03700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="156" mass="17681" checksum="20BF9E7E9026D1AB" modified="2018-12-05" version="1">MPRKGHIAKRDVLPDPMYNSKVVTKLINNVMIDGKKGVAQKICYEAFEIMAQKTGKEALEVFEEAMNNVMPLLEVKARRIGGANYQVPIEVRPERRQTLGLRWILDASRKRGEKLMAQRLAGELLDAANNTGAAVKKREDTHKMAEANKAFAHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES1</accession>
    <name>A0A386PES1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03140</name>
        <name evidence="2" type="ORF">EI377_13655</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677277.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02156"/>
    <dbReference type="EnsemblBacteria" id="AYE33531">
        <property type="protein sequence ID" value="AYE33531"/>
        <property type="gene ID" value="CP523_03140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61694">
        <property type="protein sequence ID" value="QAS61694"/>
        <property type="gene ID" value="EI377_13655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="82" mass="9074" checksum="2A125D5740E8CFC4" modified="2018-12-05" version="1">MFTIMAIKIEPRDSAAPKVQEVLTKFGCIIQTRLGLHEASKNICSNSGLVILNLIHEEKEEISKLSNELNEIKGVVAKLVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW1</accession>
    <name>A0A386PEW1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_00435</name>
        <name evidence="9" type="ORF">EI377_10925</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00615"/>
    <dbReference type="EnsemblBacteria" id="AYE33022">
        <property type="protein sequence ID" value="AYE33022"/>
        <property type="gene ID" value="CP523_00435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61191">
        <property type="protein sequence ID" value="QAS61191"/>
        <property type="gene ID" value="EI377_10925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS_1_like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="390" mass="43528" checksum="D2AE968258AB4A66" modified="2018-12-05" version="1">MKKYFNLTTYIVFGVASVLTTFYFPYLNQHVGLSLTQVGGVVSVGALFTLIAQPILSNQFSKVKNRNRFILIYLAFVFFAIIGLIVINKDLAIIFAPIYGGVLAPITGIFEIYIEDLCVKKGYEFSDIRKWGSIGYGCIVLLGGGIIAKFGYRILHILALSMIIIMALIIIFKFENTEIKIENLSKVGFKDLIKDKNIVLLALIVFLSIGSYTGLDFAYSSYLVDVTKNIDLANKIYSGSIGFRVFIEFLSFMLVTKYLSKANSKKCIMMAFTIASIKIMLFSTGVLPLIVLGDQLHGVMYSLYLTFIFKYLREVTDEKIVPSAFAILSVLSSGGANFIYPAIYSFVQEKFGYGLMYLLGFILIILAIVLTYTLLPKGKMNKTSNNDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX0</accession>
    <name>A0A386PEX0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">htpG</name>
        <name evidence="6" type="ORF">CP523_00490</name>
        <name evidence="7" type="ORF">EI377_10980</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676313.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00627"/>
    <dbReference type="EnsemblBacteria" id="AYE33032">
        <property type="protein sequence ID" value="AYE33032"/>
        <property type="gene ID" value="CP523_00490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61201">
        <property type="protein sequence ID" value="QAS61201"/>
        <property type="gene ID" value="EI377_10980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="A; substrate-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="5">
        <location>
            <begin position="551"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="624" mass="72896" checksum="9828B469EE09AF86" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY8</accession>
    <name>A0A386PEY8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679078.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33997">
        <property type="protein sequence ID" value="AYE33997"/>
        <property type="gene ID" value="CP523_05705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="93" mass="10355" checksum="7B7F2DFFB80D23FB" modified="2018-12-05" version="1">MDKGLATIGSATENVATNAGKAWVGEGYKSITDNAGNVIGYSSNDGMRAFRMQYKPREGMWRANFTENYKYINEFGDITNKQLKNVHIDILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF30</accession>
    <name>A0A386PF30_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
            <ecNumber evidence="6">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Chaperonin-60</fullName>
            <shortName evidence="6">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">groL</name>
        <name evidence="6" type="synonym">groEL</name>
        <name evidence="9" type="ORF">CP523_09635</name>
        <name evidence="10" type="ORF">EI377_04410</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676702.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02633"/>
    <dbReference type="EnsemblBacteria" id="AYE34665">
        <property type="protein sequence ID" value="AYE34665"/>
        <property type="gene ID" value="CP523_09635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60065">
        <property type="protein sequence ID" value="QAS60065"/>
        <property type="gene ID" value="EI377_04410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="541" mass="57840" checksum="B186D98262DEF4D3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF81</accession>
    <name>A0A386PF81_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_09980</name>
        <name evidence="5" type="ORF">EI377_04765</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676551.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00325"/>
    <dbReference type="EnsemblBacteria" id="AYE34703">
        <property type="protein sequence ID" value="AYE34703"/>
        <property type="gene ID" value="CP523_09980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60104">
        <property type="protein sequence ID" value="QAS60104"/>
        <property type="gene ID" value="EI377_04765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
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    </dbReference>
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        <property type="entry name" value="Major_M_immunogen_Tpp15_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363051" evidence="2">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="3">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="14913" checksum="797BB6FDB41005F1" modified="2018-12-05" version="1">MKSRKVLSLLAVAALTATVFVGCGNKEAKLKDGNYKAESAVDERGYKGSIEIEIKDGKVSEVKYDEVNEEKSTSKLTDADYNKKMKEKSGTNPEEAFPKLQNSLIEKQDASAVDTVSGATSSSNQFKDVAAEALKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF87</accession>
    <name>A0A386PF87_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl CoA:acetate/3-ketoacid CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="5" type="ORF">EI377_15700</name>
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        <lineage>
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 7">VAT12</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676215.1">
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01818"/>
    <dbReference type="EnsemblBacteria" id="AYE33904">
        <property type="protein sequence ID" value="AYE33904"/>
        <property type="gene ID" value="CP523_05140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62055">
        <property type="protein sequence ID" value="QAS62055"/>
        <property type="gene ID" value="EI377_15700"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0046952">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CoA_trans_fam_I"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="515" mass="55703" checksum="839DD05C7A056A69" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF93</accession>
    <name>A0A386PF93_CLOSE</name>
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        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_06285</name>
        <name evidence="9" type="ORF">EI377_00760</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677758.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02416"/>
    <dbReference type="EnsemblBacteria" id="AYE34107">
        <property type="protein sequence ID" value="AYE34107"/>
        <property type="gene ID" value="CP523_06285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59474">
        <property type="protein sequence ID" value="QAS59474"/>
        <property type="gene ID" value="EI377_00760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06285"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="314"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="531" mass="61747" checksum="E826E2A57076DF7D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC6</accession>
    <name>A0A386PFC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04150</name>
        <name evidence="2" type="ORF">EI377_14670</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02754"/>
    <dbReference type="EnsemblBacteria" id="AYE33721">
        <property type="protein sequence ID" value="AYE33721"/>
        <property type="gene ID" value="CP523_04150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61876">
        <property type="protein sequence ID" value="QAS61876"/>
        <property type="gene ID" value="EI377_14670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="207" mass="23485" checksum="BF032DA2737AA909" modified="2018-12-05" version="1">MKKYKCVIFDLDGTVLNTEKMNILPLQRLIKEELGEEHSYESLLKYMAYAGKKTLELLGFKDIDRSYEKWVKYVNEFEEGATLYEGFDKVIEDLSYNGILCGIASSKMRNQYEIDFFKTGLQNYMKSVVLAEDTEKHKPHPDPLLMVAKNLDIDPSKCLYVGDTIFDYKASKAAGMGFALALWGAADLSGINADYNLENPSDLLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE8</accession>
    <name>A0A386PFE8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplJ</name>
        <name evidence="6" type="ORF">CP523_08920</name>
        <name evidence="7" type="ORF">EI377_03675</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01783"/>
    <dbReference type="EnsemblBacteria" id="AYE34530">
        <property type="protein sequence ID" value="AYE34530"/>
        <property type="gene ID" value="CP523_08920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59932">
        <property type="protein sequence ID" value="QAS59932"/>
        <property type="gene ID" value="EI377_03675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="18328" checksum="A9778CC5AE11C61E" modified="2018-12-05" version="1">MNKNRQIKEAKVAEIKEKLEKAQAVVLADYQGLTVEEDTALRKSLREAGVEYKVYKNSLVTLAAKELGINGVEEYLAGPVSIAFGYEDATAPARVLHTFAKDHKKLELKAGIVEGTIYNKAEVEQLATIPPKEVLIAKLLGSFKAPLSNLAYLLNAIKEKKESESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI8</accession>
    <name>A0A386PFI8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04470</name>
        <name evidence="6" type="ORF">EI377_15010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00384"/>
    <dbReference type="EnsemblBacteria" id="AYE33781">
        <property type="protein sequence ID" value="AYE33781"/>
        <property type="gene ID" value="CP523_04470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61938">
        <property type="protein sequence ID" value="QAS61938"/>
        <property type="gene ID" value="EI377_15010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="287" mass="32873" checksum="3D97F99C8572129B" modified="2018-12-05" version="1">MLIVNNLSKSFGNFTVLEDINLEFKNGVYGLLAPNGAGKTTLIKLLTTLIFPTKGEILYDGVDIISLDEEYREILGYLPQNFGYYKNYSPKQFLMYLSALKGVNKKESSKKIDELLEMVALNDVSNKKMKKFSGGMIQRVGIAQALLNDPKILILDEPTAGLDPKERVRFRNILTELSRDRIVIISTHIVSDIEFIANEVIMIKDKKVLHKDSVENICRTLEGKVYETEIDFSMAKDFRNNHLSLSEKQEDGKMKIRFIDKEKKNNLWKSVSPNLEDVFLYEYNEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ3</accession>
    <name>A0A386PFJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05800</name>
        <name evidence="3" type="ORF">EI377_00285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674973.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34014">
        <property type="protein sequence ID" value="AYE34014"/>
        <property type="gene ID" value="CP523_05800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59386">
        <property type="protein sequence ID" value="QAS59386"/>
        <property type="gene ID" value="EI377_00285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="19194" checksum="0DF6A2F6672C3CA4" modified="2018-12-05" version="1">MLFIKPSLIFRTISLYIILVLFILIFSFFLNYFEANPCSANSLILEKQLLSLAEKSDIIKLSDITSFKWDKAYSFSPYTTKETIYETIGSQCNSINESISEGMNHLVFLKNGEVVSYLYGYPDEIGYYISFDSSFYKDGVGVISYDEDIKFKISIKNDILNLTHINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ8</accession>
    <name>A0A386PFJ8_CLOSE</name>
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        <recommendedName>
            <fullName evidence="3">HIRAN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_01850</name>
        <name evidence="5" type="ORF">EI377_12370</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02381"/>
    <dbReference type="EnsemblBacteria" id="AYE33292">
        <property type="protein sequence ID" value="AYE33292"/>
        <property type="gene ID" value="CP523_01850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61463">
        <property type="protein sequence ID" value="QAS61463"/>
        <property type="gene ID" value="EI377_12370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIRAN" evidence="3">
        <location>
            <begin position="533"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="652" mass="77166" checksum="AFAB361AC6F5336D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK8</accession>
    <name>A0A386PFK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10760</name>
        <name evidence="3" type="ORF">EI377_05545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674099.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34845">
        <property type="protein sequence ID" value="AYE34845"/>
        <property type="gene ID" value="CP523_10760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60239">
        <property type="protein sequence ID" value="QAS60239"/>
        <property type="gene ID" value="EI377_05545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="37181" checksum="CE70A331AC1F86EC" modified="2018-12-05" version="1">MPMLDMPIKEMESYRGSGIIPKDFHEYWRNEVKKVNEKKLEYKIIKKFFNNKQANYYEIYFKGIDGAEIYAKYISPAVNRKVPTVLEFHDYKEASRSWHYLTRYVAIGYSVLAMDCRGQGGKSEDIGGVKGSTVCGHVINGLDDDINRMYYRKVYLDAYILSMIAERLNKTDVNKMIAFGKGQGAALALVVSALNKNIKKCSLQYPFLADFKRVWEMDLDIDAYEGIRYYFRWFDPMHIREKEIFEKLGYIDIVNFASNLNCELLVGTALLDSICPPSTQYAIFNNANCNKKHLVFHKYGHELNNFFENENLKFMLFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL8</accession>
    <name>A0A386PFL8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33811">
        <property type="protein sequence ID" value="AYE33811"/>
        <property type="gene ID" value="CP523_04650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
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    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="899" mass="105780" checksum="91BCD0173FBFD4BB" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS3</accession>
    <name>A0A386PFS3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11060</name>
        <name evidence="4" type="ORF">EI377_05850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677098.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00928"/>
    <dbReference type="EnsemblBacteria" id="AYE34905">
        <property type="protein sequence ID" value="AYE34905"/>
        <property type="gene ID" value="CP523_11060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60299">
        <property type="protein sequence ID" value="QAS60299"/>
        <property type="gene ID" value="EI377_05850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="477" mass="53093" checksum="F35105ADCB434998" modified="2018-12-05" version="1">MKNLDYIKEKLKNSFDVKYRTVETVLGKATIVFIDDLCNSELISDNVVFPIRGFGELQPSEGKITTLQELIDNVLNINAAGLAKDKDDAVMHVLSGDPIIIFDDFEDIVYVEAKGFPVRGVGTPETESVIKGPREGFNELIVNNVALIRRRIKNPDLKFEAVVVGEKSKTAVAVTYIDGIAPEGLINEVKEKVKNLDIRFILDTNYIEDAIKKQKSFFDTVGYTEKPDEVAAKLLEGRVAVIVDGTPFVITVPYFFLENFQMPDDYYVNRYYTNFNRILRWVAFFIATLLPGLYVAVITYHFSMIPSLFMFRLAVSRAGVPFPTFIEVIIMMLAFQLIKEAGLRLPQPIGGAMSIVSALILGDAAVGAGIASRITIIIVALSTLCYFLIPKLYGAVSFWAIILVIFAALFGIPGFLCGALLLLMQLSELDTVGYPFLFPIGSVNEYKFKDVVLRGELNRISQNIIGRGKTDESKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT8</accession>
    <name>A0A386PFT8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF368 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03165</name>
        <name evidence="3" type="ORF">EI377_13680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677268.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33536">
        <property type="protein sequence ID" value="AYE33536"/>
        <property type="gene ID" value="CP523_03165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61699">
        <property type="protein sequence ID" value="QAS61699"/>
        <property type="gene ID" value="EI377_13680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="297" mass="32780" checksum="0D9318C1A8A062BF" modified="2018-12-05" version="1">MYIVNFIRGFCMALADSVPGVSGGTIAFILGFYDDFINSLNSLVSIKGGLERKKSSMAFLFKLGIGWVVGMVSSIFLLSSIFDKEIYNISSVFVGFILFSIPIIIREEKDILKENYKNIIYAILGIIVVAAITYFNPTSSGSSSVDLSNISFSLGIYVFVVGMIAISAMVLPGISGSTLLLVFGLYAPIISAVKEFLTFNLSYLPILIIFGFGVLTGIVTTIRLIRYLLKKHRSKMIYFIIGLMIGSFYAVFMGPTTLKVPRPAMNLESFSFIFFIIGGLLIVILEKSKHFLEKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG11</accession>
    <name>A0A386PG11_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05410</name>
        <name evidence="2" type="ORF">EI377_15970</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02587"/>
    <dbReference type="EnsemblBacteria" id="AYE33951">
        <property type="protein sequence ID" value="AYE33951"/>
        <property type="gene ID" value="CP523_05410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62102">
        <property type="protein sequence ID" value="QAS62102"/>
        <property type="gene ID" value="EI377_15970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="300" mass="33071" checksum="6BF9976EB75DF247" modified="2018-12-05" version="1">MRNYIVYDIGGSAVKWSVINENGEFLKSGSVGIAETVEEFFNTLSDITNKNRDEFKLEGIAISSPGAVDSESGIVYGASAIPYIHGPNFKEILFNKTGLKVEIENDANCAALGECWLGAGKKEADLAFVVCGTGIGGALVKDKRIHKGVNKHGGEFGYCIIDVDKNSENKYLTWSKVGSTAALARKIAKRKGIDIKDFNGLKAFELYENNDEIAIEEVNNYFTYMAVGIYNIQYTYDPEVIILGGGISEREGFIEEIDKRLNEIMLINKDGKIKPVVRKCEYGNNANKLGALYNFIQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG13</accession>
    <name>A0A386PG13_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04740</name>
        <name evidence="8" type="ORF">EI377_15250</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01724"/>
    <dbReference type="EnsemblBacteria" id="AYE33828">
        <property type="protein sequence ID" value="AYE33828"/>
        <property type="gene ID" value="CP523_04740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61974">
        <property type="protein sequence ID" value="QAS61974"/>
        <property type="gene ID" value="EI377_15250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="128"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="341" mass="40195" checksum="E4E35174B611AD80" modified="2018-12-05" version="1">MIRKLKGIFQKNRLWIIVIFTLNFIFGVLLWLSNDKAFIYIFPTMIIGSLILYCATAFSIYKNDLKREQAIRRFLDEPTKDVENEIISLFNYEEVEVIKDIGEILRQNQNTINTHKRGIDEYEEYIEAWAHEIKTPLGLMTFVLDNRKEEISPIVYKRLQYVRTKMQEDIERMLYYARLKSTCNDYFFKELSLQESCIEVIEEYKVILQEKSIDVILDIGDYKVLSDKRGIQFIIRQIISNSVKYKNIEISDPHIVITSYENEKNIILTIRDNGIGVKEYDIPFIFEKAFTGEIGEQRKNSTGMGLYLAKQMAKNLKITLEVNNNYTHGFEISLLFPKVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG14</accession>
    <name>A0A386PG14_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08085</name>
        <name evidence="2" type="ORF">EI377_02840</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675955.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34387">
        <property type="protein sequence ID" value="AYE34387"/>
        <property type="gene ID" value="CP523_08085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59792">
        <property type="protein sequence ID" value="QAS59792"/>
        <property type="gene ID" value="EI377_02840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="93" mass="10726" checksum="592DED7C173B558E" modified="2018-12-05" version="1">MKKNSGIFVKLNYKTIGEFKSLIIDRDIITIEEEKYLMCAGKYNKDGWTFVFKASSIKEAEELINTKSIRTKRVVNGNSHIIDTERVVIPGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG42</accession>
    <name>A0A386PG42_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigK</name>
        <name evidence="9" type="ORF">CP523_01100</name>
        <name evidence="10" type="ORF">EI377_11600</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674446.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02298"/>
    <dbReference type="EnsemblBacteria" id="AYE33149">
        <property type="protein sequence ID" value="AYE33149"/>
        <property type="gene ID" value="CP523_01100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61319">
        <property type="protein sequence ID" value="QAS61319"/>
        <property type="gene ID" value="EI377_11600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014209">
        <property type="entry name" value="RNA_pol_sigma-K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02846">
        <property type="entry name" value="spore_sigmaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26188" checksum="E6F63B8476C1B971" modified="2018-12-05" version="1">MFFISNIIELLCNSIFLTGYIAGSNTFPKPLDEKEEKHYLALLKEGDKEAKSVLIERNLRLVAHIVKKYTFPNKDVDELISIGTVGLIKAIDSFDGSKGTRLATYASRCIENEILMLFRNNKKQKSEVYLQDPIGVDKEGNEICLIDVLSSEKDSVLEKVESNLQIKSLYSKIGISLSDREGEILKMRYGLIDGRCRTQREIAALMGISRSYVSRIEKKALKKLKKEMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG68</accession>
    <name>A0A386PG68_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimI</name>
        <name evidence="3" type="ORF">CP523_10400</name>
        <name evidence="4" type="ORF">EI377_05170</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674239.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01420"/>
    <dbReference type="EnsemblBacteria" id="AYE34780">
        <property type="protein sequence ID" value="AYE34780"/>
        <property type="gene ID" value="CP523_10400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60175">
        <property type="protein sequence ID" value="QAS60175"/>
        <property type="gene ID" value="EI377_05170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="17090" checksum="3B6AA4A63F62800A" modified="2018-12-05" version="1">MEITYNLMSLNDINGVFEISNLCFAIPWSVSSIKAELNNPLAKYIVAKDKTTNSIVGFVGIWIIVGEGDITNIGVHPSYRKNNIATNLLKYLFKLCNDLNCEIINLEVRESNTPAQNLYKKFNFKEIGIRKNYYEDNKENAILMQYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG83</accession>
    <name>A0A386PG83_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS mannose transporter subunit IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03925</name>
        <name evidence="4" type="ORF">EI377_14450</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675519.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01555"/>
    <dbReference type="EnsemblBacteria" id="AYE33676">
        <property type="protein sequence ID" value="AYE33676"/>
        <property type="gene ID" value="CP523_03925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61834">
        <property type="protein sequence ID" value="QAS61834"/>
        <property type="gene ID" value="EI377_14450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="14978" checksum="E05A460691E7A065" modified="2018-12-05" version="1">MKILVVGHGEYATGIKSAIKLLTGVDENIDAINLNNDLTHEDFTTMIKKYVKENNELIIFADITGGAPFQITSREVLLNEESQDQYVIGGVSVACILDIVMNTVVIGSGDDTRKIIDNAVEGLKDMASVMCRKDLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ9</accession>
    <name>A0A386PGJ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heparinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675512.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01550"/>
    <dbReference type="EnsemblBacteria" id="AYE33672">
        <property type="protein sequence ID" value="AYE33672"/>
        <property type="gene ID" value="CP523_03900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="70"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="673" mass="78861" checksum="6F4116AC8E308D9B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP9</accession>
    <name>A0A386PGP9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine--glyoxylate aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07010</name>
        <name evidence="5" type="ORF">EI377_01755</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673674.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01018"/>
    <dbReference type="EnsemblBacteria" id="AYE34221">
        <property type="protein sequence ID" value="AYE34221"/>
        <property type="gene ID" value="CP523_07010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59626">
        <property type="protein sequence ID" value="QAS59626"/>
        <property type="gene ID" value="EI377_01755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="3">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="358" mass="40547" checksum="80F584EAE68C0352" modified="2018-12-05" version="1">MHKKLFIPGPVEVRADVLEQMAKPMIGHRSKEASILQRRISDNLRKIFYTESEILLSTTSGSGLMEGAIRSCTAKRAAVFSIGAFGKRWYEMAVANNVPADLFEVKMGQSITPEMVDRELKTGKYDLVAVTHNETSTGVMNPVEDIGEVIKKYKDIVFIVDTVSSAVGTKIEVDKWGIDICITSTQKAIGLPPGMSICTFSKKAKERAEKVPNRGFYLDLLALYKYIQKKDYQYPSTPSLSHMYALDYQLDYILNKEGLENRFKRHIEMAQVVRKWAEKYFEIFPDKKCLSNTLTTIKNTTSIDISDLNKKLGERGFQISNGYGILKDKTFRIAHMADCQISDINDLLKNINEILKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT1</accession>
    <name>A0A386PGT1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydroxylamine reductase</fullName>
            <ecNumber evidence="7">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hybrid-cluster protein</fullName>
            <shortName evidence="7">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hcp</name>
        <name evidence="8" type="ORF">CP523_08235</name>
        <name evidence="9" type="ORF">EI377_02985</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="7">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674712.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01589"/>
    <dbReference type="EnsemblBacteria" id="AYE34414">
        <property type="protein sequence ID" value="AYE34414"/>
        <property type="gene ID" value="CP523_08235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59819">
        <property type="protein sequence ID" value="QAS59819"/>
        <property type="gene ID" value="EI377_02985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="7">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="546" mass="60368" checksum="C71E455BEE884263" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW2</accession>
    <name>A0A386PGW2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_07415</name>
        <name evidence="7" type="ORF">EI377_02105</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673786.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01092"/>
    <dbReference type="EnsemblBacteria" id="AYE34291">
        <property type="protein sequence ID" value="AYE34291"/>
        <property type="gene ID" value="CP523_07415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59685">
        <property type="protein sequence ID" value="QAS59685"/>
        <property type="gene ID" value="EI377_02105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="108"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="398" mass="44003" checksum="399C553ED0169FD8" modified="2018-12-05" version="1">MFSLNKKLDINLKNCMASKIRKNYRVIIKCSKFQDSIIKKISSYKGELIRNIKPCNIISANLNTKAIERLLEYPEVEYICFDEYLFLCGMSVPTANKTRLSSKTNITGKGVGIGIVDSGVYPHPDLLTPYNRISTFVDLISDLKHPYDDNGHGTCTCGILAGSGEKSNGMYRGVAPECNLHCYKAFDRLGKGFVSDVLYAIECLIEESEKYNIKILCLPFELLYYNTFIQNCFDNIFKLATAKNITPVVPSGSNKNSEGSITGIALSKECITVAGIDTTSIIKPYPYSSAGKLKKDTKPDIAAACVDIVSLNCNVNYISEKNGVKMYPKKLNASYKSYTGTSLAAAYISGICALLYQNDPSLTFKDTVSLLKVSCEPFDMPKNYQGEGKVNINKVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW4</accession>
    <name>A0A386PGW4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">murB</name>
        <name evidence="18" type="ORF">CP523_06405</name>
        <name evidence="19" type="ORF">EI377_00880</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677414.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02157"/>
    <dbReference type="EnsemblBacteria" id="AYE34128">
        <property type="protein sequence ID" value="AYE34128"/>
        <property type="gene ID" value="CP523_06405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59495">
        <property type="protein sequence ID" value="QAS59495"/>
        <property type="gene ID" value="EI377_00880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06405"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="33"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYE34128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QAS59495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="304" mass="33249" checksum="277061099AB4EC76" modified="2018-12-05" version="1">MNQYKDFKDLFKDFYSEDSIKIDAPMKEYVHFRVGGPADILLIPNNKEQVIKTIKVCRKNNIPFYVVGNGSNLLVRDGGIRGVVIKLGNVKHIKVNENRVKAECGAMLKDVSDAALKNSLTGFEFACGIPGTVGGAVFMNAGAYNGEISHVIESAEAIDSEGNLLTLTHDELDLGYRSSVIMKKGYIVLSATFKLEKGNGNNIKEKVDDLTFKRESKQPLEYPSAGSTFKRPEGYFAGKLIEDAGLKGFSLGGAAVSQKHSGFVINKGGATAKDILDLIHHVQNEVKRQFGVELHPEVRIIGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW6</accession>
    <name>A0A386PGW6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar protein export ATPase FliI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliI</name>
        <name evidence="7" type="ORF">CP523_02600</name>
        <name evidence="8" type="ORF">EI377_13135</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673913.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00447"/>
    <dbReference type="EnsemblBacteria" id="AYE33429">
        <property type="protein sequence ID" value="AYE33429"/>
        <property type="gene ID" value="CP523_02600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61603">
        <property type="protein sequence ID" value="QAS61603"/>
        <property type="gene ID" value="EI377_13135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022425">
        <property type="entry name" value="FliI_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03497">
        <property type="entry name" value="FliI_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="157"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="436" mass="47564" checksum="F4CC0E7F4825F537" modified="2018-12-05" version="1">MIDIDFNILNKRISEINPTYCEGKVKQVIGLTIEVQGIKSFVGELCTIYNQENKPISCEVVGFREDAVLLMPLGELIGIGPGCRVVPEKIPLSVKCSDELLGKVLDGLGNPLNEEGILNGERYSLENDPPDPLKRKRIKDILPTGVRAIDGFLTVGEGQRIGIFAGSGVGKSTTLGMIAREAEADVNVISLIGERGREVLEFIEKDLGPEGMKKSIVVCATSDKPALIRIKGALTATAIAEYFRDQGKKVILMMDSVTRFAMAQREIGLAIGEPPAQKGYTPSVFAKLPKLMERPGTSDKGSITAFYTVLVDGDDFNEPIADAVRGILDGHIVLSRALAHKNHYPAIDILNSVSRLMSNIASNNHKEAASIARDLLATYKDSEDLINLGAYVRGSNPKIDTAIDYNELINRFLKQGIEEKSNFEECILNLTSMFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH70</accession>
    <name>A0A386PH70_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 6">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsL</name>
        <name evidence="7" type="ORF">CP523_08940</name>
        <name evidence="8" type="ORF">EI377_03695</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 6">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876935.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01787"/>
    <dbReference type="EnsemblBacteria" id="AYE34534">
        <property type="protein sequence ID" value="AYE34534"/>
        <property type="gene ID" value="CP523_08940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59936">
        <property type="protein sequence ID" value="QAS59936"/>
        <property type="gene ID" value="EI377_03695"/>
    </dbReference>
    <dbReference type="GeneID" id="66300449"/>
    <dbReference type="KEGG" id="csep:CP523_08940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="126" mass="13727" checksum="E8589BD85E33EEEE" modified="2018-12-05" version="1">MPTISQLVRKGRKTIVNKSTAPALNECPQRRGVCTVVKTTTPKKPNSALRKIARVRLTNGFEVTAYIGGVGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGALDCAGVANRMQGRSKYGAKKPKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD5</accession>
    <name>A0A386PHD5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pyk</name>
        <name evidence="16" type="ORF">CP523_10560</name>
        <name evidence="17" type="ORF">EI377_05340</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674183.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01389"/>
    <dbReference type="EnsemblBacteria" id="AYE34807">
        <property type="protein sequence ID" value="AYE34807"/>
        <property type="gene ID" value="CP523_10560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60201">
        <property type="protein sequence ID" value="QAS60201"/>
        <property type="gene ID" value="EI377_05340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10560"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="14">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="15">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS60201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="472" mass="51897" checksum="DE4B1586B1DB618B" modified="2018-12-05" version="1">MQKTKMIFTIGPASDNEETLKEFIKIGMSAARLNFSHGTHETHKEKIELLKKVRKEMNSPTAIILDIKGPKIRTHNFINDGAELHIGDEFTFVCGEEILGNNERCSISYSELYKDVEVGGEILVDDGLLRFEIINIEEKQIKCKIIVGGIIKNHKGVNVPNVSINLPAITEKDKEDLIFGCENKIDFVAASFIRKASDIEDVRNVLKNNGGDYIQIIAKIENQEGVNNIDSIIEAADGIMVARGDMGVEIPIERVPIIQKNIIRKCNEAGKIVITATQMLDSMIRNSLPTRAEACDICNAIFDGTDAIMLSGESASGNYPIEAASTMSKIAKETEDHLDYNYLNKRLKEPALYAFSEAISYSACRTSNLLNSKAVVAATTSGATAKLISKYRPKCPIIAITPHEEVLRGLNLNFGIFPKLCKVFSTTDDILLEAKKVAKNLSFANEGDEIIVAAGMPTIQTGGTNMLKIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE2</accession>
    <name>A0A386PHE2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name evidence="2" type="ORF">CP523_14220</name>
        <name evidence="3" type="ORF">EI377_09125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678503.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00278"/>
    <dbReference type="EnsemblBacteria" id="AYE35493">
        <property type="protein sequence ID" value="AYE35493"/>
        <property type="gene ID" value="CP523_14220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60879">
        <property type="protein sequence ID" value="QAS60879"/>
        <property type="gene ID" value="EI377_09125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="16813" checksum="A1C08C9F3A89CD18" modified="2018-12-05" version="1">MRAVVQRVSSSKVVVDDSVIGSIGRGVNVLIGISKEDTEEDLIYIRDKVINLRIFEDENSKMNLSLLDIKGEILAISQFTLYGDCRKGRRPNFMNAEGGERAKELYNRFIELLKESKLKVETGEFGADMKVDIQNDGPVTLLLESKRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE3</accession>
    <name>A0A386PHE3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-ribose pyranase</fullName>
            <ecNumber evidence="2 5">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsD</name>
        <name evidence="6" type="ORF">CP523_03515</name>
        <name evidence="7" type="ORF">EI377_14040</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RbsD / FucU family. RbsD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677921.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02254"/>
    <dbReference type="EnsemblBacteria" id="AYE33599">
        <property type="protein sequence ID" value="AYE33599"/>
        <property type="gene ID" value="CP523_03515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61763">
        <property type="protein sequence ID" value="QAS61763"/>
        <property type="gene ID" value="EI377_14040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03515"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01661">
        <property type="entry name" value="D_rib_pyranase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="131" mass="14318" checksum="8007DDCDDE726228" modified="2018-12-05" version="1">MKKTALLNSDLSEVISKMGHTDMLAIGDCGLPIPGCTKRIDLALIKNLPTFIDTLKAVLLELEVEEVVIAAEIESKNKNVYEEIKGLIGDVKITIVSHEELKVLLKDCKAVVRTGEQTPYANIILKSGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE6</accession>
    <name>A0A386PHE6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14395</name>
        <name evidence="6" type="ORF">EI377_09360</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676805.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02470"/>
    <dbReference type="EnsemblBacteria" id="AYE35525">
        <property type="protein sequence ID" value="AYE35525"/>
        <property type="gene ID" value="CP523_14395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60911">
        <property type="protein sequence ID" value="QAS60911"/>
        <property type="gene ID" value="EI377_09360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="172"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="412" mass="47343" checksum="979615A5EFEFAD02" modified="2018-12-05" version="1">MLKLNFDVKRHLLDNGLEVITIKKDTKIAAINVGIKVGSLYENGDEKGISHFIEHMLFKGTKNRSNEEINEALEFLGGEYNAYTDYAVTVYTISCLEEEIKNAIEILGDMIVASTFSEEEVEKERGVILAEIRTGKDDVEDFSFKKTNEIAFKKSPLRYDVAGLDKTVKKFIRNDLIEYYNKYYVANNSVITIVSSFEHEEALLEVKKRFGNWKKGDVEKLKVIEEENNPIKFVTNKENIEQSTITYLYTFYGLDRNLELPFRILNHRLGESANSLLFREVREKRGLAYDIYTNLDMTKGVKTFSIYTAVSEEDIESALEAIDETILGVKNGSIEIGERDLNLMKKIHKTAVITTLEDPAELCNYMLHQALDEEDLYEFVNDMDKLNELDINKIYDVANKVLEKPTIHILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH3</accession>
    <name>A0A386PHH3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09470</name>
        <name evidence="2" type="ORF">EI377_04215</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679249.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00749"/>
    <dbReference type="EnsemblBacteria" id="AYE34634">
        <property type="protein sequence ID" value="AYE34634"/>
        <property type="gene ID" value="CP523_09470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60033">
        <property type="protein sequence ID" value="QAS60033"/>
        <property type="gene ID" value="EI377_04215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="16112" checksum="ED0A8CD396120C82" modified="2018-12-05" version="1">MYHCEICGAPADIHHIVHKHEGGYDFDLNYKYLCNLHHRGKNGPHNCIETDLKYKLELQDKLYKLLPKDHYNAKELLEILRLPSCSLKRLIKNLKLYKEGYLKDEIIKNLMGGKLYFHSMLDELELERLFNNINIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN6</accession>
    <name>A0A386PHN6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679060.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35310">
        <property type="protein sequence ID" value="AYE35310"/>
        <property type="gene ID" value="CP523_13230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="136" mass="15407" checksum="07A3857D6D1E17D2" modified="2018-12-05" version="1">MGVLFKNSAVTIYNKHYDLTSDSYKYQRRVIKDVNWQGKTTGTVSDKGLLLADSTLIFIDKLANYVGPKRFANLSDIERINYFTLAPGDKVVKGEIDFEITGIKPYRIADLKNEFDDVIDIKSVNLLTDHIEVEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR7</accession>
    <name>A0A386PHR7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I SAM-dependent RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14940</name>
        <name evidence="4" type="ORF">EI377_09895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676064.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01296"/>
    <dbReference type="EnsemblBacteria" id="AYE35623">
        <property type="protein sequence ID" value="AYE35623"/>
        <property type="gene ID" value="CP523_14940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61009">
        <property type="protein sequence ID" value="QAS61009"/>
        <property type="gene ID" value="EI377_09895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="2">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="385" mass="43924" checksum="ACB68A369BF7E66B" modified="2018-12-05" version="1">MEYNLIATTTFGLEGITAKELKALGYEDLRTENGKVYFSGDEMDIAIANIHLRTADRILINMGEFEAKTFEELFQGTKKIKWSELIPKDGIMHVNGKSVKSTLHSVPDCQSIVKKSIVDSMSESYGISHFEESGPLYKIEVSILKDKVTLTIDTSGPGLHKRGYREEAGAAPLKETLAAAMVLISRWKEDFLLVDPFCGSGTILIEAAMIMQNIAPGMCRSFTCETWPTMDEDIFEQVREGAERAIKHKDIKLIGYDIDGRILKVAKSNAQKAGVYDYIEFQKRDFNEFSNSNKNGFIITNPPYGERLGEKEEVEKLYETFGMYKRRFSEWDYNILTSFEGFEKPFGRKSSKNRKLYNGKIKCYYYQYFDNNLIKNNGDMVVNHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR8</accession>
    <name>A0A386PHR8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13390</name>
        <name evidence="3" type="ORF">EI377_08280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677530.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00773"/>
    <dbReference type="EnsemblBacteria" id="AYE35340">
        <property type="protein sequence ID" value="AYE35340"/>
        <property type="gene ID" value="CP523_13390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60731">
        <property type="protein sequence ID" value="QAS60731"/>
        <property type="gene ID" value="EI377_08280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="19483" checksum="BD205643262F3A9D" modified="2018-12-05" version="1">MRTSIKVKEMVIAALLVALAIIIPIQFGFLKIIVGPFTATVASHVPMFIAMLISPITAIIVGVGSGIGFLLSGMPMHVVLRAFTHIIVGFVGAKIILKKRNFKQAIIVTAPIHGILEGLAVIPFGFNMYQVIIVTVIGTMIHHFIDGSLSFVLANSLAKVRKKDIYTTFNDKMSIDNIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX6</accession>
    <name>A0A386PHX6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal peptidase I</fullName>
            <ecNumber evidence="6">3.4.21.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04410</name>
        <name evidence="6" type="ORF">EI377_14955</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.89" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676442.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00396"/>
    <dbReference type="EnsemblBacteria" id="AYE33769">
        <property type="protein sequence ID" value="AYE33769"/>
        <property type="gene ID" value="CP523_04410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61927">
        <property type="protein sequence ID" value="QAS61927"/>
        <property type="gene ID" value="EI377_14955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="168" mass="18163" checksum="EEF48D1FBBF51E62" modified="2018-12-05" version="1">MKKTVKIIGNSIVYLLIALILISALVSKTSDSKKSPELFGYSVYSVLTGSMEPTMKTGSIVVVKNIPVNDIEKDDVITFRSNNTSNITTHRVSNIINEDGLKFITKGDANNAEDPLPVDSNLVIGKVIFNIPFLGKALIFISKNLLLIIAVLVIAMAVGSKVNNSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ3</accession>
    <name>A0A386PHZ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04525</name>
        <name evidence="3" type="ORF">EI377_15085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676406.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33789">
        <property type="protein sequence ID" value="AYE33789"/>
        <property type="gene ID" value="CP523_04525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61947">
        <property type="protein sequence ID" value="QAS61947"/>
        <property type="gene ID" value="EI377_15085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="18889" checksum="0567DF9576410AAF" modified="2018-12-05" version="1">MSSIIIKENRNELKNLIALGTIIVLLSLLILFKGVYNLNVIFIIVGIIGSIFFGYCYVFTIMKLIKPKPLIVVNNSGIIDNSTAVSIGVISWDNIIDFRIEKHFNNEYIAIDVNNLNSLIKALHPLKRIVIRLNIMFKFSPILIYIGCADISSEEILNILKKQLIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI14</accession>
    <name>A0A386PI14_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thyA</name>
        <name evidence="8" type="ORF">CP523_07065</name>
        <name evidence="9" type="ORF">EI377_01810</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673694.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01029"/>
    <dbReference type="EnsemblBacteria" id="AYE34232">
        <property type="protein sequence ID" value="AYE34232"/>
        <property type="gene ID" value="CP523_07065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59637">
        <property type="protein sequence ID" value="QAS59637"/>
        <property type="gene ID" value="EI377_01810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07065"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="263" mass="30830" checksum="8426687F1B59820D" modified="2018-12-05" version="1">MSLYDKKYLTIVQDILDNGYYDNNRTGVSTYKLPHQVMQFNLEKEFPILTTKFVAFKTAVKEMLWIYKDQSNDVTKLQEQNVHIWDEWVDENNTIGRGYGYQIAKFNQIDKLIETLKTNPQDRRMLMTMWNIEDLPHMTLQPCCFLTMWDVTDGKLNCMLIQRSGDIPLGVPFNTSQYAVLVHLIAQVTGLKPGLFTHVINNAHIYENQVEGMKLQLSRANDEYDAPKLWINPEIKNFYDFTPDDIKLENYEYHPAIKMEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG0</accession>
    <name>A0A386PIG0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TerD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family tellurium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05330</name>
        <name evidence="4" type="ORF">EI377_15895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02602"/>
    <dbReference type="EnsemblBacteria" id="AYE33939">
        <property type="protein sequence ID" value="AYE33939"/>
        <property type="gene ID" value="CP523_05330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62090">
        <property type="protein sequence ID" value="QAS62090"/>
        <property type="gene ID" value="EI377_15895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="23131" checksum="C1EB7102810A79C2" modified="2018-12-05" version="1">MAINLGSGFENLLNNQTQNTQQSGGITLDLKKNDILDLTKRNPGLKHVMLGAGWDISTNGSDFDLDIAAFLLDANNKFNTVSNIIFFNNKVGQGITLGEDNRTGAGDGDDETIQIDLGNINPSIMKIVFVVTIHNAMEKRQTFGMINNSYIRLVDKDQNGKELCRFNLKENGSTATSVIFAELNRDGSEWQFKAVGEGKIADLNGILALYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM7</accession>
    <name>A0A386PIM7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08770</name>
        <name evidence="3" type="ORF">EI377_03520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678077.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02695"/>
    <dbReference type="EnsemblBacteria" id="AYE34502">
        <property type="protein sequence ID" value="AYE34502"/>
        <property type="gene ID" value="CP523_08770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59904">
        <property type="protein sequence ID" value="QAS59904"/>
        <property type="gene ID" value="EI377_03520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="67" mass="7424" checksum="3C09A2C4E63B0860" modified="2018-12-05" version="1">MKSSLKVYNLNTQNDIMAIREAISSNEGIIACEVSISKKEVSIVYDNRVINIDSIINSLENSGYSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN8</accession>
    <name>A0A386PIN8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35690">
        <property type="protein sequence ID" value="AYE35690"/>
        <property type="gene ID" value="CP523_15320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021146">
        <property type="entry name" value="Phafe_gp6_head-tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05135">
        <property type="entry name" value="Phage_connect_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="111" mass="12732" checksum="DF09F71E80F15A0B" modified="2018-12-05" version="1">MSMTQLEKIKLRLEIDKEDKSKDDLINIVLEDAKCEILDYCNRNVILAKMEALQRELAILYYNRIGSEGESSRNEGGISVNYIIDIPESIKNRLNAFRKLKAVGIANENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN9</accession>
    <name>A0A386PIN9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08740</name>
        <name evidence="3" type="ORF">EI377_03490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678059.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02689"/>
    <dbReference type="EnsemblBacteria" id="AYE34496">
        <property type="protein sequence ID" value="AYE34496"/>
        <property type="gene ID" value="CP523_08740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59898">
        <property type="protein sequence ID" value="QAS59898"/>
        <property type="gene ID" value="EI377_03490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="383" mass="42097" checksum="BC6320E24FDAB9D2" modified="2018-12-05" version="1">MKQEIISYLSTCRNDIFDLCKYLYDNPEDSYNEIKSCKYLSNLLTKYGFNVDNNFLDLSTSFYATKGSGHPKVCFLCEYDAIPGEGHITGHNLLSATSIAAAISLGNVIDKAGGSVIVIGCPGEYLGGTKSVMVKQGVFADIDVVLLAHPDIITSESGSSSAIIPLSVKFIGNSGLSFLNKGSYTSLDGILLTFNILNSLLKGFPEDVEVNSILSQGGFTPLLLPLESEAKFYIRAKEMDIAKIAEGKLREIIIYVSKLIRVQYSMSLYEPENEELITNRTLNRLFSHNLKESGTINISEPRDVYSGLSLGIVSKTVPCIHPYISIIENNAIKYGTKDFADATISDYALEQSIKAAQALAFTGLDIIQNENLLYEVKNEFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP8</accession>
    <name>A0A386PIP8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 15" type="primary">rpoB</name>
        <name evidence="15" type="ORF">CP523_08930</name>
        <name evidence="16" type="ORF">EI377_03685</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678838.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01785"/>
    <dbReference type="EnsemblBacteria" id="AYE34532">
        <property type="protein sequence ID" value="AYE34532"/>
        <property type="gene ID" value="CP523_08930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59934">
        <property type="protein sequence ID" value="QAS59934"/>
        <property type="gene ID" value="EI377_03685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="26"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="140"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="363"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="489"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="567"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="696"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF10385"/>
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            <dbReference type="EMBL" id="AYE34532.1"/>
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    </evidence>
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    <sequence length="1236" mass="139363" checksum="88B11EF7DB69575C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE35347">
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        </source>
    </evidence>
    <sequence length="513" mass="56970" checksum="92DB595CA1975CA0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 8">VAT12</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="CP523_11955"/>
    </dbReference>
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        <property type="gene ID" value="EI377_06775"/>
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        <property type="project" value="UniProtKB-KW"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="582" mass="67319" checksum="51EA018A65B03743" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX7</accession>
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    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
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        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
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    </protein>
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675347.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02034"/>
    <dbReference type="EnsemblBacteria" id="AYE35154">
        <property type="protein sequence ID" value="AYE35154"/>
        <property type="gene ID" value="CP523_12395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60557">
        <property type="protein sequence ID" value="QAS60557"/>
        <property type="gene ID" value="EI377_07280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="380" mass="41079" checksum="6B55A9923A1883E4" modified="2018-12-05" version="1">MKEFSINTSVYLGQGALDKLNEIRNKRVLIVCDKFMETSGVAAKIQGKLVDCEVAIYSDIVPDPSLEIVAAGIQKLKSCNAEILIALGGGSSIDGAKAIREYAKKVAGGVSSIEAFYAIPTTSGTGSEVTEYAVITNKQEGLKYALADKSLLADYAILDPELVKTVPKAITADTGMDVITHAIEAYVSNTATDFSDALAEKALTLAFRFLPQAYFDGNDIMAREKLHNASCLAGMAFNASGLGVTHSLAHAIGGKLHIPHGRSNAMILPYIIEYNANLNKDSFKVEYTLAAKKYQRLAKLLNLHATNVNIGVNNLIRSIVELQNTLMIPRTLKEQGTDIELAKSIREEVVEAALNDICTKANPREATRNDLLELFDRVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ4</accession>
    <name>A0A386PIZ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12545</name>
        <name evidence="3" type="ORF">EI377_07435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675280.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02004"/>
    <dbReference type="EnsemblBacteria" id="AYE35184">
        <property type="protein sequence ID" value="AYE35184"/>
        <property type="gene ID" value="CP523_12545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60587">
        <property type="protein sequence ID" value="QAS60587"/>
        <property type="gene ID" value="EI377_07435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="304" mass="34779" checksum="D04E12108EB34AC8" modified="2018-12-05" version="1">MVIGMINKEERILEYINWLYSDYNDIGFKSDISKLDEVLGNFQKGRLITIFSRSGVGKSTLALQIALNMMINGNKIFFGSGEMSEKEVFSKMASSYCLIKYKDIIERNLDLEEKEKIKDFANEIINKDFYVSNKTNLREVVNEIKSYKKKFGLDVLFIDYVNKYVGGIEGNTLSEKIGVVTSVLKELALREDICVVLLAQANRLVDRNVSNSICEKISEADIQDSARIEQDSDQLIGLYRNKKLDNKMYRDEFRKSGKLNLNSKNSEVNPNCINAVILKNRHGEKGTKALAWSGEYSRIEDIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ5</accession>
    <name>A0A386PIZ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06295</name>
        <name evidence="2" type="ORF">EI377_00770</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34109">
        <property type="protein sequence ID" value="AYE34109"/>
        <property type="gene ID" value="CP523_06295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62143">
        <property type="protein sequence ID" value="QAS62143"/>
        <property type="gene ID" value="EI377_00770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025945">
        <property type="entry name" value="DHHW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14286">
        <property type="entry name" value="DHHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="209" mass="24986" checksum="DA5DB9F9626DBC51" modified="2018-12-05" version="1">MVIVVLNILKGDAKISESENRVLSKKPKFTIERLVNGSFSKKYERYKTDQFINRDLWISIKTNSDRILGRNKFKGVYLGKDNYLLEEFEEPNHNRVERTLNSINKFSRKYESINQYITIVPNAIEILNDKIPVFAPKISERNYIDDFKNKLNEKMNFIDSYKTLENHKDKYIYYKTDHHWTTLGAYYAFLEVAKNMDFQERNQRIMLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ13</accession>
    <name>A0A386PJ13_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13930</name>
        <name evidence="2" type="ORF">EI377_08820</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678805.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35437">
        <property type="protein sequence ID" value="AYE35437"/>
        <property type="gene ID" value="CP523_13930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60824">
        <property type="protein sequence ID" value="QAS60824"/>
        <property type="gene ID" value="EI377_08820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="73" mass="8674" checksum="297A4955DC227AB3" modified="2018-12-05" version="1">MNEGQEKFSNFIMLNVEEKNQDKSKELLTESFKKQNDGTFNKEYLITFIPRMLELIKPECVEQVKNIIINYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ33</accession>
    <name>A0A386PJ33_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12530</name>
        <name evidence="3" type="ORF">EI377_07420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675292.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02007"/>
    <dbReference type="EnsemblBacteria" id="AYE35181">
        <property type="protein sequence ID" value="AYE35181"/>
        <property type="gene ID" value="CP523_12530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60584">
        <property type="protein sequence ID" value="QAS60584"/>
        <property type="gene ID" value="EI377_07420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08352">
        <property type="entry name" value="VOC_Bs_YwkD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037478">
        <property type="entry name" value="YwkD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="127" mass="15030" checksum="951B03E8FD76971B" modified="2018-12-05" version="1">MKFNKIHHVAIICSDYNKSKKFYVEKLGLEVIREVYREERKSYKLDLKLGNSQIELFSFPNPPKRQSYPEGCGLRHLALEVDNIEKAVEELNRNGVEVEPIRVDEFTGKKFTFFEDPDKLPLELYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ35</accession>
    <name>A0A386PJ35_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34169">
        <property type="protein sequence ID" value="AYE34169"/>
        <property type="gene ID" value="CP523_06615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="412" mass="47687" checksum="052BE27E4355A038" modified="2018-12-05" version="1">MTRKIDTNFDYNEEIKRCKTIDDVMGKNGLIQRLVKDVLENILEGEMEEHLGRNKYERVEVVDQTKKNYRNGYSRKNLRSSFGDVDLDVPRDRNAEFEPQIIKKYETVCTELYKKIISLYAKGMSTSDIQAEIEDLYGITISPSMVSKITDKVLASAAEWQNRALDKIYPIVYLDAMYFKVRSNGKIVNKAVYICLGYTMEGYKDILGIWVDEAEGAKFWLGICNDLKNRGVKEILIACMDGLKGLPQAIKTVFPSVNIQTCIVHQIRNSIKYIASKDKKAFMKDLKEVYKATTEELALAQLDNLKERWGDKYGIVIDSWYNNWSNLSTFFDFSPTIRKMIYTTNILEGFNRQIRKFTKVRVIFPTDESLNKCVYLATMEILEKWTQPIHNWGATLAELSIIFEDQLKDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ43</accession>
    <name>A0A386PJ43_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11175</name>
        <name evidence="4" type="ORF">EI377_05965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00905"/>
    <dbReference type="EnsemblBacteria" id="AYE34928">
        <property type="protein sequence ID" value="AYE34928"/>
        <property type="gene ID" value="CP523_11175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60322">
        <property type="protein sequence ID" value="QAS60322"/>
        <property type="gene ID" value="EI377_05965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="48"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="323" mass="35012" checksum="03F25F4CEDF51C2F" modified="2018-12-05" version="1">MSLLSIFKKENIVESETSEKYMSAKEEIADNLDKYDKIKSQIISLSEHSSNISSSIQESNNSLTSLTKATIKQADEINSATSVLTAFNSYMNNLAYNVTNVHISILDADKLANTGLNTFSDLNESLNSLRNSFNTVTNTVNSLITKLDSINTITDSINQIANQTNLLSLNAAIEAARAGEAGKGFSVVATEVRKLAENSKGSVENISNILEDIKKDILSVSDAMSISSGAIDIQDKTLLETKDSLSNIKSSIGDSVDEINDCIVNLTTASAEKDKVVNLMNDVSIISQEHTALCEEIAANIDIQARNVEIFDESISKLENELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ54</accession>
    <name>A0A386PJ54_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR04086 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14190</name>
        <name evidence="3" type="ORF">EI377_09095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678516.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35487">
        <property type="protein sequence ID" value="AYE35487"/>
        <property type="gene ID" value="CP523_14190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60873">
        <property type="protein sequence ID" value="QAS60873"/>
        <property type="gene ID" value="EI377_09095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023804">
        <property type="entry name" value="DUF3792_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12670">
        <property type="entry name" value="DUF3792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04086">
        <property type="entry name" value="TIGR04086_membr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="122" mass="12916" checksum="1C8AD9052343B925" modified="2018-12-05" version="1">MDFKSYFRSVLKGMVGALIITVLITAIFSLIMTKVSFSEGVFNVIYVVISCIALVIGSIIGAKAHGSKGWIVGLGVGITFYIALYIIGIICGVEASLAMYDLIKFALCVLIGTLSGMLGINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ64</accession>
    <name>A0A386PJ64_CLOSE</name>
    <protein>
        <submittedName>
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    </protein>
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                <person name="Seyboldt C."/>
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            <strain evidence="4">DSM 7534</strain>
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            <authorList>
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                <person name="Leendertz F.H."/>
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            <strain evidence="2">DSM 7534</strain>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE34646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02614"/>
    <dbReference type="EnsemblBacteria" id="AYE34646">
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            <end position="119"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    <sequence length="119" mass="13808" checksum="26DB0E8D11C0191F" modified="2018-12-05" version="1">MEERKTESCSCNIIHKNVVDKVKENIPQDEILYDLADLFKAFSDSTRIKILCALFQSEMCVCDLAALLGMNQSAISHQLRVLKSSRLVKFRREGKVIYYSLDDEHVKHIFDEGFRHITE</sequence>
</entry>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
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            <dbReference type="EMBL" id="QAS60714.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="93" mass="10443" checksum="B43A297A36DE31A6" modified="2018-12-05" version="1">MDLLKFIPENLIILIVVIYVLGVFLKKLEGVKDKYITLILMFFGITFAILLNIVNGQYKVLFDVIVNGILQGILCWGVAVGINQTSKQISKEN</sequence>
</entry>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="588" mass="68532" checksum="2B2FE3C319D68F3C" modified="2018-12-05" version="1"> </sequence>
</entry>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
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            <end position="26"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="96" mass="11145" checksum="2E0B8D851BAF9861" modified="2018-12-05" version="1">MNSGFKTLLYILGVFLVITLILNLAITILPWALLFGGILYIFFKIKGWFIKRKFQKNSSEYYNRETSYSHVKVDTVNTDDVVGDIIDVDYEDVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
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            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675302.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02010"/>
    <dbReference type="EnsemblBacteria" id="AYE35178">
        <property type="protein sequence ID" value="AYE35178"/>
        <property type="gene ID" value="CP523_12515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60581">
        <property type="protein sequence ID" value="QAS60581"/>
        <property type="gene ID" value="EI377_07400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021359">
        <property type="entry name" value="DUF2812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11193">
        <property type="entry name" value="DUF2812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="205" mass="24287" checksum="DADABDAAABBEBEBC" modified="2018-12-05" version="1">MKKFKCFTNFIKEEKWLNEMANEGYRLKNVSFGYTFEKSKPENSIIKIDYRKFKTKDDFIDYCTLFEDSGWEHIVGTMYSGIQYFKKVNTSSSYEDIFSDNLSKAAVYKRLSLMWFNLAISYIVVFLPLLYAGYIDISALINPKNLYYTPSLWSMTGSDFWFHFLFETPFALGRGFLWIIFPVFIILYLIASFKSQRLYKASKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX2</accession>
    <name>A0A386PJX2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14675</name>
        <name evidence="2" type="ORF">EI377_09640</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678855.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35574">
        <property type="protein sequence ID" value="AYE35574"/>
        <property type="gene ID" value="CP523_14675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60960">
        <property type="protein sequence ID" value="QAS60960"/>
        <property type="gene ID" value="EI377_09640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="9075" checksum="643A520E7440A9A0" modified="2018-12-05" version="1">MNGYELIMRLQEKMKDPRFAEKFNRLQGELNNIPGLQQEVMRIAQMDNERSRQKAIDRLPDKAKKVMKEILKMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJY6</accession>
    <name>A0A386PJY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13065</name>
        <name evidence="2" type="ORF">EI377_07935</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677836.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35278">
        <property type="protein sequence ID" value="AYE35278"/>
        <property type="gene ID" value="CP523_13065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60672">
        <property type="protein sequence ID" value="QAS60672"/>
        <property type="gene ID" value="EI377_07935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="65" mass="7700" checksum="F868B48136BA974A" modified="2018-12-05" version="1">MKQVSLNVRQAVLKIVENLLEEHKELDIFKVAYILEDKYGIRFYNLGVLQELIMKALDEIVFIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK92</accession>
    <name>A0A386PK92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crotonase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Short-chain-enoyl-CoA hydratase</fullName>
            <ecNumber evidence="4">4.2.1.150</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09555</name>
        <name evidence="4" type="ORF">EI377_04300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.150" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676674.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02617"/>
    <dbReference type="EnsemblBacteria" id="AYE34649">
        <property type="protein sequence ID" value="AYE34649"/>
        <property type="gene ID" value="CP523_09555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60048">
        <property type="protein sequence ID" value="QAS60048"/>
        <property type="gene ID" value="EI377_04300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="260" mass="28171" checksum="A28AF2658402293F" modified="2018-12-05" version="1">MELKNVILEKEGNLAIVTINRPKALNALNSETLKDIDTVVSDLEKDRNIYCVILTGAGEKSFVAGADIAEMRELNERQGKEFGLLGNKVFRKLEKLDKPVIAAISGFALGGGCELAMSCDIRIASEKAKFAQPETGLGITPGFGGTQRLARIVGEGKAKELIYTGAIIKADEALRIGLVNKVVPLESLMDEAKAMANTIIANAPIAVKLCKDAINRGMQVDIDSAIEIEAEDFGKCFSTEDQVEGMTAFIERRSKNFYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM0</accession>
    <name>A0A386PKM0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPOR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10570</name>
        <name evidence="3" type="ORF">EI377_05355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
        </source>
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            <begin position="21"/>
            <end position="43"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="25879" checksum="343B48EEBF0A0D5E" modified="2018-12-05" version="1">MRYTKYQYKKKNNGIGFLTSVVMTVFAAGIIGLVIAKVIFSFIPVKDDGSISTGIESPEKPATVGQGEEVFSFVQCGMFSNQDNANKALSDVGNDYNSFILEDDSKFRVSAGIFNLEQGNKISEELTKKGVTNAQMKFVLNKEDEIENQISAITSGYLDIVNALNDKEVKSVKTTDFKNWANELPEISKGDNLESLNDFKKHISELPDELKKENVIQELKYIYTILVKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
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            <strain evidence="5">DSM 7534</strain>
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                <person name="Leendertz F.H."/>
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        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS60914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="118" mass="13892" checksum="AF62A844B659BC09" modified="2018-12-05" version="1">MDYFNEGNRFYNLKEYKNAIDCYKLSIDKYENVACSLYNSGVCYIKLKDFNNAISMIKKALELQKESKYFFNLAYCYAMLEDTNKALIYFNIAWSLDDSDNDCEKAIKLIMSKKKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKN6</accession>
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    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_06205</name>
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    </gene>
    <organism evidence="8 10">
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        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="CP523_06205"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
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            <end position="74"/>
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        <location>
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        </location>
    </feature>
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            <end position="199"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62142.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="517" mass="57523" checksum="69316EF472CE1EB3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKN7</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35332">
        <property type="protein sequence ID" value="AYE35332"/>
        <property type="gene ID" value="CP523_13345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60722">
        <property type="protein sequence ID" value="QAS60722"/>
        <property type="gene ID" value="EI377_08235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038733">
        <property type="entry name" value="Predicted_DNA_bind_prot_RHH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12651">
        <property type="entry name" value="RHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_3" evidence="1">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="55" mass="6451" checksum="D0E7F3EB4FC5FEC1" modified="2018-12-05" version="1">MADKKDSLVNRQRYSSTFDIELLEKMKELSKETSIPMSKLLDKALELLLKEHNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP6</accession>
    <name>A0A386PKP6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mgsA</name>
        <name evidence="4" type="ORF">CP523_13400</name>
        <name evidence="5" type="ORF">EI377_08290</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677536.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00775"/>
    <dbReference type="EnsemblBacteria" id="AYE35342">
        <property type="protein sequence ID" value="AYE35342"/>
        <property type="gene ID" value="CP523_13400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60733">
        <property type="protein sequence ID" value="QAS60733"/>
        <property type="gene ID" value="EI377_08290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="122" mass="13403" checksum="48A19E51A581BE8A" modified="2018-12-05" version="1">MNIAIIAHDEKKEEMIEFVKKYKDVFVKHNIFATGTTGGLIEKHIGLNVCRYLSGPLGGDQQIGAKIAVGEIDIVIFFRDPLTAQPHEPDVTALIRLCDVHNTPVATNFGAAEVFLKAITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKS3</accession>
    <name>A0A386PKS3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14695</name>
        <name evidence="7" type="ORF">EI377_09660</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678848.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00135"/>
    <dbReference type="EnsemblBacteria" id="AYE35578">
        <property type="protein sequence ID" value="AYE35578"/>
        <property type="gene ID" value="CP523_14695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60964">
        <property type="protein sequence ID" value="QAS60964"/>
        <property type="gene ID" value="EI377_09660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="172"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="362" mass="41379" checksum="D88C0CBCA57E6CE6" modified="2018-12-05" version="1">MSELNHELGIIALESCKELGNMVDAYIKNKRNCEDSFLIPLNEIRFSNGEGKVKISETVRGKDIYILCDIGNYSCTYKMFGFTNHKGPDEHFQDIKRTVSAIRGKSARITVIMPLLYESRQHRRKGRESLDCALALQELERLGVDEIITFDVHDPNVQNAIPLLSFENIYPTYDIVKSLICNEDSLELNKEELLVISPDTGAMDRAIYYSSVLGVDVGLFYKRRDHSLIVNGKNPIVQHEYMGREVEGKDVLIVDDMIASGESVLDIATELKARKARNVYIATTFAFFTEGLEKFNKYYEKGIITKVYSTNLTYIPDNLMVAEWFKAVDMSEFLSRIINRLNYGKSIAKYMDATQVIRRLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL00</accession>
    <name>A0A386PL00_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14265</name>
        <name evidence="2" type="ORF">EI377_09175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676762.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02442"/>
    <dbReference type="EnsemblBacteria" id="AYE35502">
        <property type="protein sequence ID" value="AYE35502"/>
        <property type="gene ID" value="CP523_14265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60888">
        <property type="protein sequence ID" value="QAS60888"/>
        <property type="gene ID" value="EI377_09175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="90" mass="10191" checksum="F538D868EDD22053" modified="2018-12-05" version="1">MFEENEKLRKDIINRLKRIEGQVKGIQGMMEKNVCCGDILIQISAIRSAINKVGGLTIEHYANNCLGIEEDSAQQENLKKLIKTINTFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL10</accession>
    <name>A0A386PL10_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14320</name>
        <name evidence="7" type="ORF">EI377_09230</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676780.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35512">
        <property type="protein sequence ID" value="AYE35512"/>
        <property type="gene ID" value="CP523_14320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60897">
        <property type="protein sequence ID" value="QAS60897"/>
        <property type="gene ID" value="EI377_09230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="270" mass="30242" checksum="FFF0CE9ABF7A8054" modified="2018-12-05" version="1">MIMFDGIYSFISVILSLAALVVCNIIKEKDNKDFPFGKYILEPLVICINSIVLIIMCLYSLYEAYNALISGGNPINAGSAIMYSIISVVGCGLFYLLIKKVENESNSELIKTQSMQWLMDGILSAAVLIGFIIAIIILKTPMASLANYIDPLMVMVTSIFFLKAPIKILKSSFKEIIGARIPEEISVEVEKQVQVIKKEYNFIQAVTKVLKIGRSVKIEINFILNDENNNISLEEMNSIKTKLYSDIDSENYFKDMKVLFSTNKTVVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL31</accession>
    <name>A0A386PL31_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15565</name>
        <name evidence="3" type="ORF">EI377_10280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678693.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00169"/>
    <dbReference type="EnsemblBacteria" id="AYE35738">
        <property type="protein sequence ID" value="AYE35738"/>
        <property type="gene ID" value="CP523_15565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61077">
        <property type="protein sequence ID" value="QAS61077"/>
        <property type="gene ID" value="EI377_10280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="148"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="298" mass="34371" checksum="3318E62F9E6A7051" modified="2018-12-05" version="1">MDHKYLKDVKNGEKIESCLMVMKILSIEDNSIIAYIGDKTSEVKAIITYKDSTPKVGEVIMVKGIFKSPFKVEAIKKIEKFDVYTYIPSVKRPVEDIIKELDEITRDEFKSPEVIAINDYFFKNEEFLKKFKMAIGGVYHHHNYLGGLAEHTLNVTYLAKVFAHRYDCRYKELAILGAKLHDIGKVREMYYGGPFGYTLEGEMEGHIVIGVSMLEDAFRENKEMYSDEFKERLKGIIVQHHGKLEYGSPKSPKSQESFIVHYADYVDATLNKVDIISQGINPGQWTDYERRIEGRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL94</accession>
    <name>A0A386PL94_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_04580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01746"/>
    <dbReference type="EnsemblBacteria" id="AYE35818">
        <property type="protein sequence ID" value="AYE35818"/>
        <property type="gene ID" value="CP523_04580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025285">
        <property type="entry name" value="DUF4145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13643">
        <property type="entry name" value="DUF4145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="358"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1115" mass="129415" checksum="169E038BFCA39B8E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLC9</accession>
    <name>A0A386PLC9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678567.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35672">
        <property type="protein sequence ID" value="AYE35672"/>
        <property type="gene ID" value="CP523_15220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="70" mass="7944" checksum="FB96FF94D42D47FF" modified="2018-12-05" version="1">MNNEKIEVISKGILEDDNLIEEEKEIALKILKDLEGTLVIRATSILKFCLKAIQYSKIKKSKVTSKEVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLD6</accession>
    <name>A0A386PLD6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">U32 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14630</name>
        <name evidence="3" type="ORF">EI377_09595</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35566">
        <property type="protein sequence ID" value="AYE35566"/>
        <property type="gene ID" value="CP523_14630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60952">
        <property type="protein sequence ID" value="QAS60952"/>
        <property type="gene ID" value="EI377_09595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="1">
        <location>
            <begin position="375"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="782" mass="89584" checksum="65AA3FD7D3A9A66D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM01</accession>
    <name>A0A386PM01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14815</name>
        <name evidence="3" type="ORF">EI377_09775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676105.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01320"/>
    <dbReference type="EnsemblBacteria" id="AYE35599">
        <property type="protein sequence ID" value="AYE35599"/>
        <property type="gene ID" value="CP523_14815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60986">
        <property type="protein sequence ID" value="QAS60986"/>
        <property type="gene ID" value="EI377_09775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="103"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="425" mass="49951" checksum="C6B46431A8567140" modified="2018-12-05" version="1">MKILFIACYSPLINNSASIETLQYLNNLVKIKENEVHLLTVNFPSNSIYYDEYIFNMLDKRVKLHIISGGKIFEKIMPKKIIADKKNINKSNSSKLKGILKNIKKIFAVPDMYLYWALKASKYGNALMDKENFDVIFSMHEPPSSHICAYNIKKKNRNVPWITYWSDPWLNDSTREDSGVIRKSIESNLEKKVISLSDKFIFVTEDNRDDYIKSYNIEKEKTFVITRGYDEKTYKEIEKEEKPKLINDNKINLVYTGEIFTKLRDIRPFIKALNLIKEHNNNFYEKLNVLFFGNIDNDDIKEELKNISIAKVSDRIPYKEALKYMVNGDILLLFGNKNSKQIPAKIYDYFGCYGYILVILGDEKDPIINVVNNKEKCRVVLNHENEIEKFLMELSLKVEKGEKTFPVEEYEWKQISKRLNEILKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAW4</accession>
    <name>A0A386PAW4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ORF">CP523_00700</name>
        <name evidence="6" type="ORF">EI377_11190</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676388.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00671"/>
    <dbReference type="EnsemblBacteria" id="AYE33073">
        <property type="protein sequence ID" value="AYE33073"/>
        <property type="gene ID" value="CP523_00700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61242">
        <property type="protein sequence ID" value="QAS61242"/>
        <property type="gene ID" value="EI377_11190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00700"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="38103" checksum="03811C9602191B87" modified="2018-12-05" version="1">MERRKTRKVKVGNVYVGGDANVSIQSMTNTDTRDTEKTLEQINILYKAGCEIIRCAVPDSKAAEALKEICEKSPIPVVADIHFDYRLALESIKNGVSALRINPGNIGSEERVKMVAEAAKAKGIPIRIGVNSGSLEKDILERDGKPTAKGLVESAMRHVKILEELNFFDMVISIKSSDVTMMIEAYRLMSETVDYPLHLGVTESGTPFRGTIKSSIGLGTLLAEGIGDTIRVSLTSDPIEEIKVAKEILKALNLKENGLQFISCPTCGRTQINLIKIAQEVEKKLENINKNIKVAVMGCVVNGPGEAREADIGIAGGKGEGIIFKKGKIIKKVKEENLIEELMKEIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB04</accession>
    <name>A0A386PB04_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">CP523_00805</name>
        <name evidence="5" type="ORF">EI377_11300</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674605.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02359"/>
    <dbReference type="EnsemblBacteria" id="AYE33093">
        <property type="protein sequence ID" value="AYE33093"/>
        <property type="gene ID" value="CP523_00805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61263">
        <property type="protein sequence ID" value="QAS61263"/>
        <property type="gene ID" value="EI377_11300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="81" mass="9250" checksum="B796DBC48B1932C8" modified="2018-12-05" version="1">MAVKIRLRRMGAKKAPFYRVVVADSRCPRDGRFIEEIGYYNPLTEPAEIKINEEKATKWVQNGAQPTDVVKRLFAQAGINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB17</accession>
    <name>A0A386PB17_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00905</name>
        <name evidence="3" type="ORF">EI377_11400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674552.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02338"/>
    <dbReference type="EnsemblBacteria" id="AYE33113">
        <property type="protein sequence ID" value="AYE33113"/>
        <property type="gene ID" value="CP523_00905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61283">
        <property type="protein sequence ID" value="QAS61283"/>
        <property type="gene ID" value="EI377_11400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="116" mass="12941" checksum="0F620DD1211FECA9" modified="2018-12-05" version="1">MVGYSNELGNVHYSEEVLAKIVGLSTMECYGVVGMVSKNATEGFWELMRIENLSKGVKLNFNDDDKLLIELFVMVEYGTKISVIANNIIQKVRYSVENFTGLKVSSITVNVQAVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB30</accession>
    <name>A0A386PB30_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ORF">CP523_00970</name>
        <name evidence="8" type="ORF">EI377_11465</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674523.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02325"/>
    <dbReference type="EnsemblBacteria" id="AYE33125">
        <property type="protein sequence ID" value="AYE33125"/>
        <property type="gene ID" value="CP523_00970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61295">
        <property type="protein sequence ID" value="QAS61295"/>
        <property type="gene ID" value="EI377_11465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00970"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="6"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="188"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="192"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="398" mass="43859" checksum="A11B20A9C1FC77D4" modified="2018-12-05" version="1">MKKKCVCIGVSGGIAVYKALDIISALRKKDVEVRVIMTSSAKEFVTPLSFQSLSQNMVITDMFAEPKAWEIQHISLAKKADLFLIVPATANIIGKVANGIADDMLSTTVMATKAKVIFAPAMNTNMYENPIVKGNIKKLKDYGYEFIEPEAGRLACGDTGKGKLADVNTIVEKVLEELEGSNKEKDLLGKKVLITAGPTRSHIDPVRYITNRSTGKMGYEIAKEARDRGAEVTLISGPTSLENPKGINFIKIDTNEEMKDIVLQYFHNSDIVIKSAAVADYKIKEYSNKKIKKGDGDLNLAFTRDNDILQLLGNEKTNQILVGFAAESNDVLENAKRKLFKKNLDFIVANDITSNETGFGSEDNKVIIISKTGKEVHLDKMSKREVASNIFETILGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB36</accession>
    <name>A0A386PB36_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00090</name>
        <name evidence="2" type="ORF">EI377_10570</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678939.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32960">
        <property type="protein sequence ID" value="AYE32960"/>
        <property type="gene ID" value="CP523_00090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61132">
        <property type="protein sequence ID" value="QAS61132"/>
        <property type="gene ID" value="EI377_10570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="95" mass="11109" checksum="EE4E389AE392D402" modified="2018-12-05" version="1">MKALKIKANINTTDDFDPNMFEEAFKIVFLNTGYTIYSLNINKIAEKNYDIIYYVEISENMNFVFAVEALNNTINQYNTFTIKNVDKLQLVEFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBP0</accession>
    <name>A0A386PBP0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recO</name>
        <name evidence="9" type="ORF">CP523_02185</name>
        <name evidence="10" type="ORF">EI377_12705</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674047.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00530"/>
    <dbReference type="EnsemblBacteria" id="AYE33353">
        <property type="protein sequence ID" value="AYE33353"/>
        <property type="gene ID" value="CP523_02185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61523">
        <property type="protein sequence ID" value="QAS61523"/>
        <property type="gene ID" value="EI377_12705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="28681" checksum="39A30723F0E1BEDB" modified="2018-12-05" version="1">MVFLSLYKTNAVIIKTTEFKENDKLVWLYTEKFGKITTIAKGSRKSKSKFLSLTLPLCYGEYVVFKGKSLYNMQEGKIINSFQGLLNNLDKLTYSSYLCELIDICLQEGDNDNSLFRDFLTCLYLLDTDALDYELLIRSFELKLLKATGYGLDLDKCSICRKKIGISNYISLFHYGGVCETCNREHGLYISRPAYNALRFLSNTPMDKIYRLNVNSEIKKDIGKVTTFIISSNYSKKPKSLEMLNYIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBV5</accession>
    <name>A0A386PBV5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoflagellar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02570</name>
        <name evidence="2" type="ORF">EI377_13105</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673925.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00453"/>
    <dbReference type="EnsemblBacteria" id="AYE33423">
        <property type="protein sequence ID" value="AYE33423"/>
        <property type="gene ID" value="CP523_02570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61597">
        <property type="protein sequence ID" value="QAS61597"/>
        <property type="gene ID" value="EI377_13105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="63" mass="7252" checksum="0F95F609B43AB1D0" modified="2018-12-05" version="1">MINLTGMNNVELILNADHIEKIESVPETVITLVSGKKYLVLESTDEVVEKVIRYKNKIVTYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCA3</accession>
    <name>A0A386PCA3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation integral membrane protein YlbJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ylbJ</name>
        <name evidence="3" type="ORF">CP523_00875</name>
        <name evidence="4" type="ORF">EI377_11370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674564.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02344"/>
    <dbReference type="EnsemblBacteria" id="AYE33107">
        <property type="protein sequence ID" value="AYE33107"/>
        <property type="gene ID" value="CP523_00875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61277">
        <property type="protein sequence ID" value="QAS61277"/>
        <property type="gene ID" value="EI377_11370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014226">
        <property type="entry name" value="Spore_IM_YlbJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02871">
        <property type="entry name" value="spore_ylbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="395" mass="43626" checksum="CE6EBF39472C4CB5" modified="2018-12-05" version="1">MYSIYILWLLIFILSILFIKLLNIKKNYIVCFCTTILIILFIINLEDCMTAALTGCSLVLKAIVPTIFPFTVICSILISYDGIELYSKIMGPLFCKPLGLSKACSFPIAASFLCGYPLGAKYCSDIYEMGYINEKEYQRVLNIATNAGPIFLIGSVGAAMLSNAKYGYILLIANYLSIIIVGFLTKKNYSNCQITNNITPNFKSKNFGTALKDAIESGINTTLTVGAFVVMFSVFISIIKNNAQISIVLHNLENLINLPADSLYGLFLGSIEFTNGCKLISTTSLPISLQLSIISFICSFSSLSVIAQVSSVVSKCNPPLGKYILWKFIQGILSFFITFFASKILITTTTTSSIIVSTEKIYTNNFISFIPVILILTLTLIFKVIFKTFKKLHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCG0</accession>
    <name>A0A386PCG0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication-associated recombination protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01195</name>
        <name evidence="4" type="ORF">EI377_11695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674381.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02279"/>
    <dbReference type="EnsemblBacteria" id="AYE33167">
        <property type="protein sequence ID" value="AYE33167"/>
        <property type="gene ID" value="CP523_01195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61337">
        <property type="protein sequence ID" value="QAS61337"/>
        <property type="gene ID" value="EI377_11695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="414" mass="46692" checksum="E92C67D620C59968" modified="2018-12-05" version="1">MYKPLAELMRPSTLDDFVGQRHIIGKGKPLYNLISRKIIPNCILYGPPGTGKTTLANIMANYADRKFYKLNATTASVKDIQEITSSLDSLLNYNGVVIYIDEIQHFSKKQQQALLEFIENGRVTLIASTTENPYFAIHKAIISRCNIFNFKQLESSDVIIGLEKAINKLINEDVDVEYSKEALSYIGDISQGDYRKAYNILELAINSQLTNKKEITVNYIESLNQSHMRADATGDEFYNLLSALQKSIRGSDENASIHYLARLIKSGNLTAIIRRISVIAAEDIGLAHPNALTVVNSGIELALKVGLPEAQIILSELVIYLATLPKSNSAYLAIKNAMDDLENKNIGDIPQYLKDAHYSGAKELGVKGYKYPHDYDNNYVKQQYIPNEIKEVKYYNPQKNKYEESLKKYWSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCU7</accession>
    <name>A0A386PCU7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3784 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04560</name>
        <name evidence="3" type="ORF">EI377_15115</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33795">
        <property type="protein sequence ID" value="AYE33795"/>
        <property type="gene ID" value="CP523_04560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61953">
        <property type="protein sequence ID" value="QAS61953"/>
        <property type="gene ID" value="EI377_15115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="109" mass="12132" checksum="2BAD0EE4F4E3E96D" modified="2018-12-05" version="1">MKPADLTGILVFAFLVGGILTFLGSIIKFFNAGDILNFFDESKHDKDKVSKIVGKDLLTIGVSVIIIAIIGIFINEKYYNFIMISQAAIVILGLVITIYHQFFKCKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCW4</accession>
    <name>A0A386PCW4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mnmA</name>
        <name evidence="8" type="ORF">CP523_01175</name>
        <name evidence="9" type="ORF">EI377_11675</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674394.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02283"/>
    <dbReference type="EnsemblBacteria" id="AYE33164">
        <property type="protein sequence ID" value="AYE33164"/>
        <property type="gene ID" value="CP523_01175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61334">
        <property type="protein sequence ID" value="QAS61334"/>
        <property type="gene ID" value="EI377_11675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="359" mass="40349" checksum="C77EC883F527F912" modified="2018-12-05" version="1">MKKKVVVGMSGGVDSSVAAYLLKEQGYEVIGVTMKHFDESDDSYVEREGGCCSLSAVDDARRVADNLGIPFYVLNFKESFKEKVIDYFVEEYIEGKTPNPCIACNRHIKFDEFLRKAKGIGADYIATGHYAKIENRDGKFHLLRADDDRKDQTYALYNFTQEQLSQTLMPCGNYTKDKIREIAKEIGLAVHNKKDSEEICFVTDNDHGRYILNAKPEKVKEGNFVDKKGNILGRHKGIVYYTIGQRKGLGLALGRPVFVTDINPRTNEVVIGAEEDIFKTDLVAKDINFIFIDNLKEDMKVTAKVRYSAKPAEATISPLPNGRVKVSFKEKQRAITKGQSVVFYNENDVVGGGIIEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCZ0</accession>
    <name>A0A386PCZ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smpB</name>
        <name evidence="4" type="ORF">CP523_03840</name>
        <name evidence="5" type="ORF">EI377_14375</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675490.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01540"/>
    <dbReference type="EnsemblBacteria" id="AYE33660">
        <property type="protein sequence ID" value="AYE33660"/>
        <property type="gene ID" value="CP523_03840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61822">
        <property type="protein sequence ID" value="QAS61822"/>
        <property type="gene ID" value="EI377_14375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="156" mass="18061" checksum="5C975E93D3BF16B7" modified="2018-12-05" version="1">MVRKKNSNTLADNRKARHDYFVEETMEAGIALVGTEVKSIRAGKCNLKDCYADIDNGEIFIKNMHISHYEQGNIFNVDPLRERKLLLHKEQISRFAGLVSQQGYTLIPLSLYLKEGKVKVALGLCRGKKNYDKRDSMLEKAHKRDIERQMKNSNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDI5</accession>
    <name>A0A386PDI5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rimP</name>
        <name evidence="6" type="ORF">CP523_00690</name>
        <name evidence="7" type="ORF">EI377_11180</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676384.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00669"/>
    <dbReference type="EnsemblBacteria" id="AYE33071">
        <property type="protein sequence ID" value="AYE33071"/>
        <property type="gene ID" value="CP523_00690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61240">
        <property type="protein sequence ID" value="QAS61240"/>
        <property type="gene ID" value="EI377_11180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="152" mass="17260" checksum="B4D2B4306269D7C4" modified="2018-12-05" version="1">MKVDALIQTIDQLVRPIADELNYEIYHIEYVKENGEYYLRIYIDKDGGIALSDCEALSRRVSDVLDEKDPIATAYFLEVSSPGLNRGLFTDAHFEKQIGKEVLIRFTKSLDGRKNVKGVLKEVKEDVIIVEDKDLVTIPKDKIKSANLDGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDL6</accession>
    <name>A0A386PDL6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673923.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00452"/>
    <dbReference type="EnsemblBacteria" id="AYE33424">
        <property type="protein sequence ID" value="AYE33424"/>
        <property type="gene ID" value="CP523_02575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="4">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="5">
        <location>
            <begin position="797"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="883" mass="92354" checksum="05210B464A84F2C5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDN8</accession>
    <name>A0A386PDN8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rsmB</name>
        <name evidence="13" type="ORF">CP523_00945</name>
        <name evidence="14" type="ORF">EI377_11440</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674528.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02330"/>
    <dbReference type="EnsemblBacteria" id="AYE33121">
        <property type="protein sequence ID" value="AYE33121"/>
        <property type="gene ID" value="CP523_00945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61291">
        <property type="protein sequence ID" value="QAS61291"/>
        <property type="gene ID" value="EI377_11440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="12">
        <location>
            <begin position="165"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="255"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="439" mass="49908" checksum="040B5980C859EF3D" modified="2018-12-05" version="1">MNIRKLARQIVQRVLEEGAYSNIVLSKELNNNEISDLDKGLITEIVYGTLRRKKTLDVIIGNFVKDIKLMDETVLNILRVAIYQIHFLDKIPEYAACNEAVEEAKEVSLEASKLVNGILRNYIKDEKDLVVPGNRIDELAYKFSLQPWMIRLFIKQYGEERTLKLMAGLNETPKVTVRVNSVKADYDEVYEKLEAMEYNIEEGYACPEAIEIIGGKGLESNELFRDGLITVQDESAMLVAPILDIKEGDLVLDLCAAPGGKTTHIAELLNNTGEVLAFDLHENKLSLIEENAKRLGLTNIKCKSMDASKLDVKYVSSSDKVLIDVPCSGLGIIRKKPEIKWNKTRQQLKDLVPIQREIMENAWQYLKPNGTLVYSTCTLNKEENEENIQWFLSKHKDAKVEKIFIGNNSNFIYNQDGTLTILPNEHMDGFYIAKIQKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDP4</accession>
    <name>A0A386PDP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677789.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34123">
        <property type="protein sequence ID" value="AYE34123"/>
        <property type="gene ID" value="CP523_06380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="208" mass="24007" checksum="31782E9BD73CDF5D" modified="2018-12-05" version="1">MVQGCIYDLRTVLMLGLPIWIIIRIATLIVKKKSGEKISVGKEIITNIFVIYCLLLIGVTLFPIEIMFGDGLSELRSIYTFKQRLGINIIPLRDYIYGIIRLRDSDIGYFFFIRSIVGNIILLVPFIGYLLMYKKKLRTAKNVIVTSFLISFSIEILQLIENITYLSGMSVRTVNIDDLILNTLGGILAYYFFKFIYKSKLRVYLNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDS4</accession>
    <name>A0A386PDS4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TerD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family tellurium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05335</name>
        <name evidence="4" type="ORF">EI377_15900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677993.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02601"/>
    <dbReference type="EnsemblBacteria" id="AYE33940">
        <property type="protein sequence ID" value="AYE33940"/>
        <property type="gene ID" value="CP523_05335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62091">
        <property type="protein sequence ID" value="QAS62091"/>
        <property type="gene ID" value="EI377_15900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="193" mass="20993" checksum="40EA33E641141980" modified="2018-12-05" version="1">MAGVLNLQKNDILDLTKAEPGLSKVMLGAGWDVVKKSGFFSFAKNYDLDLVALQIDNSGHLLNNGLIYFGHQSGVGIKLHGDNLTGEGDGDDEKISVDLTRLPSGCAKVVFAVTIYDAKVRKQSFSGVKNAYVRLLNEDKGGSEICRYNLSEDGGDNTAIIFAELERINGNWQFKAKGELLKASISTLADMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDU0</accession>
    <name>A0A386PDU0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_05455</name>
        <name evidence="8" type="ORF">EI377_16015</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677954.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02577"/>
    <dbReference type="EnsemblBacteria" id="AYE33960">
        <property type="protein sequence ID" value="AYE33960"/>
        <property type="gene ID" value="CP523_05455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62111">
        <property type="protein sequence ID" value="QAS62111"/>
        <property type="gene ID" value="EI377_16015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="36319" checksum="6B54C0088E1F0D1C" modified="2018-12-05" version="1">MIKKSKKERVSKKQRFKRFKNNKELLLLTVPGTIWFLIFAYLPMFGVIIAFKDWKIHGGFLESLVKSEWVGLKNFKFLFQSSDAWLITKNTVAYNLVFIILGIVIPVTLAILLKELLNKRGSKFYQSSMFLPYFLSWVVVSYCLYAFLSPEKGYINGVLSSFGVDTVSWYTEPKFWPFIIIFMSQWKGIGYGTVVYLAAICGIDKTYYEAAIIDGANKWQQIKHITIPLLKPVLIIMFITAIGGMFRSDFGLFYQLPKNSGALYPVTNVIDTYVYRGLMNLGNIGMSSAAGLYQSFVGLVLILVTNGIVRKVDSENAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE23</accession>
    <name>A0A386PE23_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05990</name>
        <name evidence="3" type="ORF">EI377_00470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34050">
        <property type="protein sequence ID" value="AYE34050"/>
        <property type="gene ID" value="CP523_05990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59422">
        <property type="protein sequence ID" value="QAS59422"/>
        <property type="gene ID" value="EI377_00470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="129" mass="14371" checksum="2C8EF2ABE9AF6F5A" modified="2018-12-05" version="1">MSKKNKARKNNNGSSIANKNVYKSPVSELSARKTDYDIPTFGFKSALLLVAAAVLGSIIVPFILSLFGISKELGVVLGNATITSFAVPYSRFFIETKRGFCKKFWMTYGIFALSFGVISYFWMYLGTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE68</accession>
    <name>A0A386PE68_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">CP523_07635</name>
        <name evidence="10" type="ORF">EI377_02325</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673853.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01136"/>
    <dbReference type="EnsemblBacteria" id="AYE34323">
        <property type="protein sequence ID" value="AYE34323"/>
        <property type="gene ID" value="CP523_07635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59718">
        <property type="protein sequence ID" value="QAS59718"/>
        <property type="gene ID" value="EI377_02325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
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                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
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            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
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    <sequence length="212" mass="24561" checksum="D2037E2435C6167D" modified="2018-12-05" version="1">MGLLFVMTIGIIVYSTFLKKYLISNNIKISKWFIIGLYIFAYYLGVVFEITGPGNIFDIGRDMNMIVNLVPFKDIIAGSDFMMNLFQLTANIILFIPLGILLPSLFERFEKFHNTLLMGFMLSLIIEIFQLLNVRATDIDDLLMNTLGAVIGFIIYSLLLKKFTSKLKLKNRNNGETLIKYNSEFFISIMFYLYFFITPCADRILNKLIFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="403" mass="42575" checksum="2D63956CED8EE07F" modified="2018-12-05" version="1">MKKLGLIPKLILAIILGIIIGSFCPKGVIGVLATFNSIFGNFLGFMIPLIIVGFVVCGIADLGKGAGKMLGLTTGIAYISTLVAGFLAFLVASKFFPLFIHTSSSLSNASNPEDKLVPALFVVDIPPIMSVMTALIFAFLLGLGISSLKGKALYNMANEFQQIVELTIKNLIIPLLPIHILGIFANMTFAGEVKSILSVFWKVFLVILALHFTMMFLQFLIASILGKKNLPSVLKNQIPGYLTALGTQSSAATIPVNLQCAEKNKVSKEVREFVVPLGATIHLSGSTITLTCCAVAVMLLNNVTPDLGKMITFIAMLGVTMVAAPGVPGGAVMAALGVLQSVLGFSEPQIALMIALYITQDSFGTACNVSGDNAIAIIVDSLKNKFNLTVSKDSNNDSLESTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ3</accession>
    <name>A0A386PEJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NfeD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Nodulation efficiency protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_01825</name>
        <name evidence="5" type="ORF">EI377_12345</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02386"/>
    <dbReference type="EnsemblBacteria" id="AYE33288">
        <property type="protein sequence ID" value="AYE33288"/>
        <property type="gene ID" value="CP523_01825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61459">
        <property type="protein sequence ID" value="QAS61459"/>
        <property type="gene ID" value="EI377_12345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="143" mass="16185" checksum="704DA9D488C7FF0B" modified="2018-12-05" version="1">MLSIIFWIVVAVIVTVLDILTSSFLFVWFAVGGFAAMVASMLGATWWLQVMVFLIVSIITISIGYPWAKKKFKASIKHTPLMEETYIGRVMKAESDILQKARVKVNGIYWTVQNQGDIIKKDSNFRIVGIEGNKLIVNKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ4</accession>
    <name>A0A386PEJ4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein CP523_07055</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07055</name>
        <name evidence="4" type="ORF">EI377_01800</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673690.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01027"/>
    <dbReference type="EnsemblBacteria" id="AYE34230">
        <property type="protein sequence ID" value="AYE34230"/>
        <property type="gene ID" value="CP523_07055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59635">
        <property type="protein sequence ID" value="QAS59635"/>
        <property type="gene ID" value="EI377_01800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="114" mass="12153" checksum="0CE89DE092600E2E" modified="2018-12-05" version="1">MAKGGFPGGFGGGNINNLMKQAQKLQKDMEQMQKDLETKEFEASVGGGAVVVKANGKKEVISINIKPEVVDADDVEMLEDLVLSAVNEVLRKAEEETANNMGKLTGGMNIPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK8</accession>
    <name>A0A386PEK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF378 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01945</name>
        <name evidence="3" type="ORF">EI377_12465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678270.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01159"/>
    <dbReference type="EnsemblBacteria" id="AYE33308">
        <property type="protein sequence ID" value="AYE33308"/>
        <property type="gene ID" value="CP523_01945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61478">
        <property type="protein sequence ID" value="QAS61478"/>
        <property type="gene ID" value="EI377_12465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37304">
        <property type="entry name" value="PTHR37304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7385" checksum="B29B8143A5226BD7" modified="2018-12-05" version="1">MKFLDIIALILVIVGAVNWGLIGFFQFDLVAALFGTMTMFSRVVYALVGLAGLYSLSFFAKDSSVNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEL7</accession>
    <name>A0A386PEL7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name evidence="2" type="ORF">CP523_00870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02345"/>
    <dbReference type="EnsemblBacteria" id="AYE33106">
        <property type="protein sequence ID" value="AYE33106"/>
        <property type="gene ID" value="CP523_00870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="401" mass="45430" checksum="3C96C76C33B5D3C7" modified="2018-12-05" version="1">MNITGIITEYNPFHSGHLYHLNSAKEITNCDGVICIMSGNFIQRGAPAIIDKWARAEMAIENGVDLVIELPSFYALSSAEIFAKGSVTILDSLGVVNSIFFGSESGNIEELINISKILAYEPLEFKNLLKSNLKKGITYAKARENSLKEFTNNIDISKILNNSNNILGIEYIKTLIRLNSNINPLTLTRVGGTYNDKTLNNDFSSATSIRESIKNSGSLNDIKSSMPYKSYEILKNLKDNNYEFVFEEKMFNLIKYKLISNCVKFNNLLDISEGLDKKILKEIYVSNSFKELLFNIKSKRYTYTKISRILTKIFIGLDLFDSNQLLNTENLYARILAFNSNGKFILKEMKNKSSIPIITKLPRNIDNPLLNLDIQSTKCYSILNNKLNPLSDYLKSPIIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ2</accession>
    <name>A0A386PEQ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">mutL</name>
        <name evidence="7" type="ORF">CP523_00150</name>
        <name evidence="8" type="ORF">EI377_10745</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677401.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01202"/>
    <dbReference type="EnsemblBacteria" id="AYE32972">
        <property type="protein sequence ID" value="AYE32972"/>
        <property type="gene ID" value="CP523_00150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61160">
        <property type="protein sequence ID" value="QAS61160"/>
        <property type="gene ID" value="EI377_10745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="462"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="648" mass="74349" checksum="534C94398F917A53" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU5</accession>
    <name>A0A386PEU5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02440</name>
        <name evidence="3" type="ORF">EI377_12965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673961.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00479"/>
    <dbReference type="EnsemblBacteria" id="AYE33398">
        <property type="protein sequence ID" value="AYE33398"/>
        <property type="gene ID" value="CP523_02440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61572">
        <property type="protein sequence ID" value="QAS61572"/>
        <property type="gene ID" value="EI377_12965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="42"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="177" mass="20489" checksum="35540F6DAB599E31" modified="2018-12-05" version="1">MRSDLKEVPVQFNADLPYPKIEVDTENLQYANLIQINYAGMVSEFSAITQYTYHEIKLFEDYADVTPTLMGIAEVEMHHMQILGELIVVLGGDPGYWINKKNKKLNWSPNFVQYGTTLKEMLTYDIESEKAAIAQYRKTANQIQDENIIAIINRIILDEEHHLKLLNGLYEKYITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ9</accession>
    <name>A0A386PEZ9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsO</name>
        <name evidence="8" type="ORF">CP523_00645</name>
        <name evidence="9" type="ORF">EI377_11135</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00660"/>
    <dbReference type="EnsemblBacteria" id="AYE33062">
        <property type="protein sequence ID" value="AYE33062"/>
        <property type="gene ID" value="CP523_00645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61231">
        <property type="protein sequence ID" value="QAS61231"/>
        <property type="gene ID" value="EI377_11135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="10131" checksum="EEFE377568BD5466" modified="2018-12-05" version="1">MDAIRKQEIIKEHARHEGDTGSPEVQIALLTERINSLTGHLKVHKKDHHSRRGLLMMVGQRRGLLNYLADQDIERYRAIIKKLGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF27</accession>
    <name>A0A386PF27_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimM</name>
        <name evidence="6" type="ORF">CP523_00795</name>
        <name evidence="7" type="ORF">EI377_11290</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674608.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02361"/>
    <dbReference type="EnsemblBacteria" id="AYE33092">
        <property type="protein sequence ID" value="AYE33092"/>
        <property type="gene ID" value="CP523_00795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61261">
        <property type="protein sequence ID" value="QAS61261"/>
        <property type="gene ID" value="EI377_11290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="19073" checksum="013D1D4309054EE4" modified="2018-12-05" version="1">MKEILRVGKIVNTHGLKGEVKVIPLTDDPKRYNDLEKVLIDNVERKIIGCKFQKDRVIVKIEGIDSIEEAEKYKNKYIEISREDAVELEEDCYFITDLIGSTVVDTDGNNLGKIYEVLQTKNNDVYWIREPKEILIPVLLDIVLDIDIDNKIITIKPVGEWQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF47</accession>
    <name>A0A386PF47_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Uracil-xanthine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02965</name>
        <name evidence="9" type="ORF">EI377_13480</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679183.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00025"/>
    <dbReference type="EnsemblBacteria" id="AYE33498">
        <property type="protein sequence ID" value="AYE33498"/>
        <property type="gene ID" value="CP523_02965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61667">
        <property type="protein sequence ID" value="QAS61667"/>
        <property type="gene ID" value="EI377_13480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="429" mass="45176" checksum="41D0AB85EA682F4D" modified="2018-12-05" version="1">MAQYVETKENYQSQVVKRGLRKGILGLQHLIAMFGATVLVPMITGLDISVALFSAGVGTLIFHFCTKRKVPVFLGSSFAFIPVIGAVTNQYGDLRYAQGGIFVAGLVYVAVSFLIKKIGVSKIKKVLPAQVVGPMIIVIGLNLIPTALDMAGVNSVIAGVEGSGKSLTIAMVTLALALLIKKFAKGFLSQISIIIAVAIGYTLSLILGVVDVNTIKEASLVAVPNFTLPKFNFGAIMIVVPVVLAVFMEHIGDITTNGQVVGENFIEDPGLNRTLLGDGLATIAASLLGGPANTTYGENTGVLAITKNYDPAILRLTAIFAIILSFVDKFGATIKTIPSSVMGGISIMLFSMIALVGVQTIKNEKVEFNSKNIVVMGVIMFIGLSGIFLKNPIAIEITESVSISGLSLAALVGVILNAILTKIYNKSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC4</accession>
    <name>A0A386PFC4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">CP523_10185</name>
        <name evidence="11" type="ORF">EI377_05000</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676643.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00366"/>
    <dbReference type="EnsemblBacteria" id="AYE34743">
        <property type="protein sequence ID" value="AYE34743"/>
        <property type="gene ID" value="CP523_10185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60145">
        <property type="protein sequence ID" value="QAS60145"/>
        <property type="gene ID" value="EI377_05000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="283" mass="31928" checksum="87A78FE3A1B22323" modified="2018-12-05" version="1">MGSAGLIEIKRRMKSVESTRKITKAMNLVSTSKLRKARKELAANEKYYDLCHEIVSELMAALPMDYESPFFNSKVKTSDKLYIVISSDTGLCGGFNGNIASRLNDMVEDKSKAKVVVAGSKGISYMKRYRFDTVGEYVEIPDVPTVKEIKAIYQDALYMFRKGDVSEVNVVFTEFISPIKQEVKIERLFPIEREGNVQGDFLIEPSLDEVLNSSLDVYFKSKLRRAMLHSKVSEQSARMTAMDGATRNANDILQNLSIKYNRIRQTMITQEISEIVGGAEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH4</accession>
    <name>A0A386PFH4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase T</fullName>
            <ecNumber evidence="7">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aminotripeptidase</fullName>
            <shortName evidence="7">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">pepT</name>
        <name evidence="11" type="ORF">CP523_01690</name>
        <name evidence="12" type="ORF">EI377_12210</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00890"/>
    <dbReference type="EnsemblBacteria" id="AYE33262">
        <property type="protein sequence ID" value="AYE33262"/>
        <property type="gene ID" value="CP523_01690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61433">
        <property type="protein sequence ID" value="QAS61433"/>
        <property type="gene ID" value="EI377_12210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="10">
        <location>
            <begin position="206"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="7 8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="406" mass="45533" checksum="7C641148A4D0314A" modified="2018-12-05" version="1">MKKVEERFLEYIKIDTKSDETTGLTPSTKGQLKLAEILAEELKKIGVNKVEISENGYVYAVLEKNCDKNIPTIGFIAHMDTAPDYCGLNVNPQIVQNYDGGDIKLNDEVILSPKFSPELRDYIGKTLITTDGTTLLGADDKAGIAEIMTAIEYLVNHPEIKHGDIKIGFTPDEEIGEGADHFNVEMFKADFAYTIDGGAIGELEFENFNAAGVKVEIKGVNVHPGYAKNKMINSIMVAHEFINKLPLNEVPEKTEKYEGFSHLTDIKGSIEKTTLDFIIRDFFADTFEERKEKFKEIEKELNEVYGEGVVTVKVKEQYRNMKEKIEPIMHIVETAKKAMEDANVTPKVKPIRGGTDGARLSYMGLPTPNLFAGGENFHGKYEYIPIESMEKAVEVILNIVRIYSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK0</accession>
    <name>A0A386PFK0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein FlaG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02685</name>
        <name evidence="2" type="ORF">EI377_13210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676945.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00943"/>
    <dbReference type="EnsemblBacteria" id="AYE33446">
        <property type="protein sequence ID" value="AYE33446"/>
        <property type="gene ID" value="CP523_02685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61617">
        <property type="protein sequence ID" value="QAS61617"/>
        <property type="gene ID" value="EI377_13210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005186">
        <property type="entry name" value="FlaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035924">
        <property type="entry name" value="FlaG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37166">
        <property type="entry name" value="PTHR37166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03646">
        <property type="entry name" value="FlaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160214">
        <property type="entry name" value="SSF160214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="113" mass="12715" checksum="A76795B3DC7EEC38" modified="2018-12-05" version="1">MLGKLVSGVGQTNLSIYSAQDSQVLGDNEVIERIPDSESEKEKILKAIDELNKFLKEKNTYVKYSVHEEFGDVMIKIINSDTDEVIMECPPKKILDFVAKMCKMVGVMVDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK4</accession>
    <name>A0A386PFK4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CP523_10695</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674135.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01363"/>
    <dbReference type="EnsemblBacteria" id="AYE34833">
        <property type="protein sequence ID" value="AYE34833"/>
        <property type="gene ID" value="CP523_10695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10695"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017409843" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="14">
        <location>
            <begin position="25"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="15">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="416" mass="46562" checksum="9A07123243B92BA3" modified="2018-12-05" version="1">MKKFIVTSLLTLIFFINFNVYTTSAEAVPTLEAEGVVLMDGTTGEIIYSKNPNTKYEPASTTKVMTALITLENCKLDDKVTIGSNPPEVDGTIIGVAKGEVYTVKELLLGLLLESGNDAAEALAEHISGSNEAFGKLMTKKAKELGANNTVFKNPSGLHEEGHVTTAYDLSLIMKTAYNNKDFLEISRTPYYIFKNNPNFDGSEKWANNKNHCINPNSPYYYEYAVSGKTGYTPEANHTYTSVAKKGDQVLIASFLNATDKDTQFRNVGELFQYGFDNFQTTKIVSKGEKLSEYKINDNITIPLLATTDVYFTQSKSDPKPIVSVTYENRDISKKTINKGDLLFNSSILVNNKDFAKIDLSSGIDRDYSFKVKVSEYLQKLKEDKPKLLIASFTFLIIILFLLFILKIIKKKRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP8</accession>
    <name>A0A386PFP8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04810</name>
        <name evidence="2" type="ORF">EI377_15320</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675782.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33841">
        <property type="protein sequence ID" value="AYE33841"/>
        <property type="gene ID" value="CP523_04810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61987">
        <property type="protein sequence ID" value="QAS61987"/>
        <property type="gene ID" value="EI377_15320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="90" mass="10899" checksum="6B3CEF855D48CE43" modified="2018-12-05" version="1">MERKNFTVIDNWILESEDLNIEEKYFLIALKKFDHRNCGEVFPSYKSLMMICSTKRKAKISKLIKALVEKGYIEKKIIKRVNHYYFKKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV3</accession>
    <name>A0A386PFV3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_00575</name>
        <name evidence="13" type="ORF">EI377_11065</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676343.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00646"/>
    <dbReference type="EnsemblBacteria" id="AYE33049">
        <property type="protein sequence ID" value="AYE33049"/>
        <property type="gene ID" value="CP523_00575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61218">
        <property type="protein sequence ID" value="QAS61218"/>
        <property type="gene ID" value="EI377_11065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00575"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="369"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="476" mass="53949" checksum="CC6A456BCDCC0B8E" modified="2018-12-05" version="1">MRDLYSTPLNSRYASKEMSYIFSDDMKFSTWRKLWVALAESESELGLNISKEQIDELKANIHNINYEEAIKKEKEVRHDVMSHVYAYGLQCPLAKGIIHLGATSCYVGDNTDIIIMRDALLLIKSKMVSVLKHLSDFAIKYKDMPTLGFTHFQPAQLTTVGKRATLWMQDLVLDIENIDFLLSTLKLRGVKGTTGTQASFMNLFEGNEEKVKALDSMVAKKMGFEKSYGVTGQTYPRKLDSIVLNTLSEIAQSAYKFSNDLRLLQSMKEIEEPFEKHQIGSSAMAYKRNPMRSERMGSLARYVIVNSLNPAITAATQWFERTLDDSANKRIAVAEAFLALDGVLNLYINIAENMVVYEKVITSHVNNELPFMATENIMMEAVKRGGDRQELHERIRLHSMDAAARVKGEGLDNDLIARIIEDDSFKLTKNEILEIIDPSKFVGRSPSQVIEFINEYINPILNSNKDALEIKSEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY1</accession>
    <name>A0A386PFY1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsE</name>
        <name evidence="8" type="ORF">CP523_06485</name>
        <name evidence="9" type="ORF">EI377_00965</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677444.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02174"/>
    <dbReference type="EnsemblBacteria" id="AYE34144">
        <property type="protein sequence ID" value="AYE34144"/>
        <property type="gene ID" value="CP523_06485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59512">
        <property type="protein sequence ID" value="QAS59512"/>
        <property type="gene ID" value="EI377_00965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="228" mass="25545" checksum="89C519795BFABEAB" modified="2018-12-05" version="1">MIEFKNVSKLYDNNVKALSDVNINIGTGEFVFLVGPSGAGKSTFIKMLLKEVDPTMGEITVAGKELASITRRQTPYYRRKIGMVFQDFRLIPTLNVYENVAFAMRVVEATPKEIRKRVPMVLSLVGLSHKYKMFPNELSGGEQQRVSLARAIVNNPSVLICDEPTGNLDPETAKEIMELLDDINRAGTTILMATHAKDIVDSMKKRVIAIEKGCITRDEKRGMYEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG05</accession>
    <name>A0A386PG05_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33818">
        <property type="protein sequence ID" value="AYE33818"/>
        <property type="gene ID" value="CP523_04690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="343" mass="40728" checksum="04EC9986E15D1707" modified="2018-12-05" version="1">MVTNERKQNTCNKYHEYLRIIDILGNKMMLQKQFIELSIALGVVKDKFQAIKGIQELERAEIIKKIKFSGTSNKFILFRKYAIRYLAKANKSSDVSGISVVNSNKRYIENIMKVQFILTTIIPTAKKNNIELTLDNLIEFIDKLNCNILYKDNNMYKFYEQLLNRTSLFFDKEEMEVDFQRLKDEHDKRIKNLKGIGEVNEKKYRKNKYDYLFNSDIATLSRKNIYLVNIKYSKKTDTTRIIAYYFNISIDKNSYAVALNYSILYNTMKRLFGNNINIEFRVICLNQLIQERIIEDLNKKGINPRTKEKRVDTYLVEMLRNNKLTEVDFLKINMKILSYDLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG08</accession>
    <name>A0A386PG08_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11485</name>
        <name evidence="9" type="ORF">EI377_06300</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673308.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34985">
        <property type="protein sequence ID" value="AYE34985"/>
        <property type="gene ID" value="CP523_11485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60378">
        <property type="protein sequence ID" value="QAS60378"/>
        <property type="gene ID" value="EI377_06300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="437" mass="47961" checksum="5160D46CD21826F7" modified="2018-12-05" version="1">MEKREEFSSKMGFILSCVGAAIGLGNIWMFPYKLGENGGAVFLIPYFIFVLILGTVGLITEFSFGRQYKKGSLGAIREVFKEKNLKGGWIISIIPTLGLTGIFMFYTVVIGWVLKYFFISLTGEIKNINTEIYFTTFTNSNITIFWHALAVVITLIIVSFGVSKGIEKINKIIIPLLFIIFIILIIKSLSLSGSSEGIKYLLKPDWSYLFKIKTWVMAMGQAFFTVSLTGCCMVVCGSYADNKFDIPNCAINTALFDTLSAMLAAFMIMPAVFALGLSPTAGPALLFVTVPSIFQTMPFGNLLSTLFFLSVIFASISSSIAMLEGPVEAIMSLKKWSRKKSSIIIATVSFILGIPLSLSGDIFDKFTNFITIILSPIGAVITAFVFYYVIDNRIALSELNKGAKKKLGIGFIKFGKYMFVPATIIIIVLGIIYGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG60</accession>
    <name>A0A386PG60_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase (NADPH), homotetrameric</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NADPH-dependent glutamate synthase</fullName>
            <ecNumber evidence="3">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltA</name>
        <name evidence="2" type="ORF">CP523_03820</name>
        <name evidence="3" type="ORF">EI377_14355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675482.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01536"/>
    <dbReference type="EnsemblBacteria" id="AYE33656">
        <property type="protein sequence ID" value="AYE33656"/>
        <property type="gene ID" value="CP523_03820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61818">
        <property type="protein sequence ID" value="QAS61818"/>
        <property type="gene ID" value="EI377_14355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="49800" checksum="50D8440DF6DE8312" modified="2018-12-05" version="1">MDMKDRMKRTPVTEQAPEVRATNFEEVCLGYNEEQAIREANRCLGCKNPKCVEGCPVSVNIPGFIAKAKEGDFEAAAKEIAKYSALPAVCGRVCPQESQCEGKCVLGIKGEAVAIGKLEKFTADWARKHNIDLTEKEESKGKKVAVIGSGPAGLTCAGDLAKRGYDVTIFEALHEPGGVLVYGIPEFRLPKDEVVKAEIENIKKLGVKIETNVIIGRTITIDELMEEEDFKAVFIGSGAGLPKFMGIQGENANGVFSANEFLTRVNLMKAFKEDYHTPVKVGKKVAVVGGGNVAMDAARTALRLGAETHIVYRRSESELPARAEEIHHAKEEGIIFDVLTNPTEIITDESGWVKGMKCVKMELGEPDASGRRRPVVVDGSEFVMDVDTVIMSLGTSPNPLISSTTKGLETNKWKCIVADEEGLTTKEGVYAGGDAVTGAATVILAMGAGKKAAEAIDEYLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG95</accession>
    <name>A0A386PG95_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">CP523_03975</name>
        <name evidence="6" type="ORF">EI377_14495</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679264.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01948"/>
    <dbReference type="EnsemblBacteria" id="AYE33686">
        <property type="protein sequence ID" value="AYE33686"/>
        <property type="gene ID" value="CP523_03975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61841">
        <property type="protein sequence ID" value="QAS61841"/>
        <property type="gene ID" value="EI377_14495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03975"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="248" mass="26704" checksum="BB3D562FD973592E" modified="2018-12-05" version="1">MRRPIIAGNWKMHYTPEEAVKVITELKPLVKDANCDVVICPTFVCLDAALKAAAGSNIKIGAQNMHFEEKGAFTGEVAPGMLEAMGVDYVVLGHSERREYFNETDEALNKKVKVAFAHNLTPILCCGETLEQRENGTTNAVVGAQIKADLEGLSKELAEKVVVAYEPIWAIGTGKTATNEQANETIAAIRGILAEMFGKEVADKIRIQYGGSVKPNTIKDQMAMSDIDGALVGGASLVASDFSQIVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA7</accession>
    <name>A0A386PGA7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YabP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yabP</name>
        <name evidence="1" type="ORF">CP523_08560</name>
        <name evidence="2" type="ORF">EI377_03310</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674880.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01653"/>
    <dbReference type="EnsemblBacteria" id="AYE34477">
        <property type="protein sequence ID" value="AYE34477"/>
        <property type="gene ID" value="CP523_08560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59879">
        <property type="protein sequence ID" value="QAS59879"/>
        <property type="gene ID" value="EI377_03310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012504">
        <property type="entry name" value="Spore_YabP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038705">
        <property type="entry name" value="YabP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011576">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02892">
        <property type="entry name" value="spore_yabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="97" mass="11062" checksum="B1C7977B2B46C712" modified="2018-12-05" version="1">MEKKGENKIEDARGNITLENRKKLTLTGVEEVISFDDEKILLNTNLGSLTIRGEELKMNKLDVQNGDVIIVGRIASMIYSGKEVKKEKENILKRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE8</accession>
    <name>A0A386PGE8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_07535</name>
        <name evidence="15" type="ORF">EI377_02225</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673812.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01116"/>
    <dbReference type="EnsemblBacteria" id="AYE34304">
        <property type="protein sequence ID" value="AYE34304"/>
        <property type="gene ID" value="CP523_07535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59698">
        <property type="protein sequence ID" value="QAS59698"/>
        <property type="gene ID" value="EI377_02225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="178"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="445" mass="49641" checksum="1D6406F6BA90C7E1" modified="2018-12-05" version="1">MDAPIMRSLPQSIEAEQSVIGSMIIDKSAIARVLEKLNEDDFYRDGHKVLYKAIREMFSQDMAVDLVTLLEYLKSTDMLDKAGGVTYISELSASVPTTANLSSYIKIVEEKSLLRKLIKSSTEIIEESYNNQDKVDGVLDKAQKKIFDIAEKKGSNDYEPLSNVLERGFLEIEKLFNNKGSITGVGSGIRDLDAKTSGFQKGDMVLIAARPSMGKTTFSLNIAENAALKEGKSVVIFSLEMSKEQLAYKLLCSEASVDMLKLRTGNLDDDDWERIARATGPLSKAKIFIDDTAGLSVMEMRSKCRKIKMEHGIDMILIDYLQLMSGSSGSESRQQEVSEISRSIKALAKEMECPVIALSQLSRAPEQRADHRPMLSDLRESGSIEQDADVVMFLYRDEYYNKETEDKNIGECIIAKQRNGPVGTVKMAWIGAHSKFANLELVYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG8</accession>
    <name>A0A386PGG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein jag</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_07640</name>
        <name evidence="8" type="ORF">EI377_02330</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673854.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01137"/>
    <dbReference type="EnsemblBacteria" id="AYE34324">
        <property type="protein sequence ID" value="AYE34324"/>
        <property type="gene ID" value="CP523_07640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59719">
        <property type="protein sequence ID" value="QAS59719"/>
        <property type="gene ID" value="EI377_02330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="23922" checksum="24558644F6220A92" modified="2018-12-05" version="1">MKILEMTGKTVNEALQNALKQLSVTEDKVEVEVIEEGNKGLLGIIGVKPAKILVKVKRDYVEEAHNFLRSVLDSMNVKAEIRIKEDNDVIYVDLTGPKMGLIIGYRGETLDSLQYLLSLVVNKGHDIPYKKVVLDTENYRKKREETLKRVANKTAYKVAKNKRSFKLEPMNPYERRIIHSTLQENDLVCTYSEGEEPYRRVVVDIRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ0</accession>
    <name>A0A386PGJ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03850</name>
        <name evidence="3" type="ORF">EI377_14385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675498.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33662">
        <property type="protein sequence ID" value="AYE33662"/>
        <property type="gene ID" value="CP523_03850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61824">
        <property type="protein sequence ID" value="QAS61824"/>
        <property type="gene ID" value="EI377_14385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012544">
        <property type="entry name" value="PHb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08000">
        <property type="entry name" value="bPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="125" mass="14401" checksum="1989E23A92B4AFC7" modified="2018-12-05" version="1">MGLFNGIMGNASEVKIEDLKKEYVKILAPSENIEKAYKLIRDMFIFTNKRLILVDKQGVTGKKTEYHSIPYRAITHFKIETSGHFDLDAELKIWISGTDLPIEKQFNSSLNIYELQAVLAEYCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGK6</accession>
    <name>A0A386PGK6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">CP523_09055</name>
        <name evidence="9" type="ORF">EI377_03800</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678367.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00250"/>
    <dbReference type="EnsemblBacteria" id="AYE34557">
        <property type="protein sequence ID" value="AYE34557"/>
        <property type="gene ID" value="CP523_09055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59957">
        <property type="protein sequence ID" value="QAS59957"/>
        <property type="gene ID" value="EI377_03800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="120" mass="13360" checksum="A7940EB4985F5F25" modified="2018-12-05" version="1">MFKKVDRKASRERRHLRVRKKISGTPERPRLSVYRSEKNIYAQIIDDVNAVTLVSASSLDKDFAVKAGGNKEAAKLVGELVAKKALEKGISEVVFDRGGYVYHGRVQTLAEAAREAGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR0</accession>
    <name>A0A386PGR0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04215</name>
        <name evidence="2" type="ORF">EI377_14740</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676509.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00433"/>
    <dbReference type="EnsemblBacteria" id="AYE33732">
        <property type="protein sequence ID" value="AYE33732"/>
        <property type="gene ID" value="CP523_04215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61889">
        <property type="protein sequence ID" value="QAS61889"/>
        <property type="gene ID" value="EI377_14740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="24585" checksum="90256F26F74675B8" modified="2018-12-05" version="1">MAKNNSVKGNFHYNNIEKMNKNFMYNNLTRSNCYNSSFAGSNFNFASFRGAHFKSCDFYGCTFKSAEFIGTNLKNSKFRHGKFEDTLFEGVNLNEVDFRDAEFKNTIFVECNLDTCKSLFFDKEEVTIYEEMPKLNISEELEEAINKAMENEFIKASRVIDTKEGKINPIKIIMLQKKYNEEVLIKGFNDMAEAVDRDFHTLSYLFRFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR3</accession>
    <name>A0A386PGR3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ImmA/IrrE family metallo-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677832.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02549"/>
    <dbReference type="EnsemblBacteria" id="AYE35275">
        <property type="protein sequence ID" value="AYE35275"/>
        <property type="gene ID" value="CP523_13045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="152" mass="17726" checksum="FDDAA634E28796E7" modified="2018-12-05" version="1">MTYEELLIEADKLGIIVKEADLKTKEGHCYGKRIAIHKYLSNYEKACVLAEELGHYYLTVGDITNQLYINNKKQELLARRWGYNKKIGLIGFIKAFESGCVNRYEMAECLNVTVDYLNEAIEYYASKYGIMHRIDDYIIYFSPNFYIGKAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW8</accession>
    <name>A0A386PGW8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="12">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nrdG</name>
        <name evidence="14" type="ORF">CP523_08385</name>
        <name evidence="15" type="ORF">EI377_03130</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674786.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01618"/>
    <dbReference type="EnsemblBacteria" id="AYE34444">
        <property type="protein sequence ID" value="AYE34444"/>
        <property type="gene ID" value="CP523_08385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59847">
        <property type="protein sequence ID" value="QAS59847"/>
        <property type="gene ID" value="EI377_03130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS59847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="169" mass="19572" checksum="38D92E9F1C236E79" modified="2018-12-05" version="1">MKKTIRLSGIAYESLVNGPGMRRVFFSQGCKHNCNGCFNPDTHDFFAGEDRDMDELIKDVLDNPILKGVTFSGGDPFERAEEFAYMAREFKKHNLNIWSYTGYTFEYILRNIDEIPGWRDLLECIDVLVDGKFEKNKMQDNLRYRGSTNQRIIDVKESLKNGVVKILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY5</accession>
    <name>A0A386PGY5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0210 protein CP523_13415</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13415</name>
        <name evidence="3" type="ORF">EI377_08305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0210 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00778"/>
    <dbReference type="EnsemblBacteria" id="AYE35345">
        <property type="protein sequence ID" value="AYE35345"/>
        <property type="gene ID" value="CP523_13415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60736">
        <property type="protein sequence ID" value="QAS60736"/>
        <property type="gene ID" value="EI377_08305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08025">
        <property type="entry name" value="RNR_PFL_like_DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01221">
        <property type="entry name" value="UPF0210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="451" mass="47455" checksum="1F9C941FA2C7B362" modified="2018-12-05" version="1">MNVNNILETIKMIEEEKLDIRTITMGISLLDCIDSDGDKAREKIYNKIVTSAKKLVKVANEIENEFGIPIVNKRVSVTPISIIAGATDEENYVKFAETLDKAAHTLGIDFIGGFSALVQKGYTKSDRILIKSIPEALEKTTKVCSSVNVGSTRCGINMDAVKEMGEIIKETADLTKDAKGFGCAKLVVFCNAVEDNPFMAGAFHGVGEADRIINVGVSGPGVVQRALEKVKGESFDVVSETIKKTAFKITRMGQLVAKEASSRLGVPFGIVDLSLAPTPAVGDSVAHILEEMGLEVVGTHGTTAALALLNDAVKKGGVMACSHVGGLSGAFIPVSEDAGMIDAVLNGSLNLEKLEAMTAICSVGLDMIAVPGNTPAESISAMIADESAIGMINNKTTAVRIIPAPGCNVGDMVEFGGLLGTAPVMPVNKYSSSLFIKRGGRIPAPIHSFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH07</accession>
    <name>A0A386PH07_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="3 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_13575</name>
        <name evidence="15" type="ORF">EI377_08470</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679035.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00091"/>
    <dbReference type="EnsemblBacteria" id="AYE35375">
        <property type="protein sequence ID" value="AYE35375"/>
        <property type="gene ID" value="CP523_13575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60765">
        <property type="protein sequence ID" value="QAS60765"/>
        <property type="gene ID" value="EI377_08470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13575"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
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    <feature type="domain" description="PK" evidence="13">
        <location>
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            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023317"/>
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            <dbReference type="RuleBase" id="RU000504"/>
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            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE35375.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS60765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="342" mass="39162" checksum="B2256A569C370223" modified="2018-12-05" version="1">MHIIATVGPRSEEKWVLKEFINKGVDILRLNCSHFNKEEFSNVVSYSREIKKDIHIMTDLCGEKIRVSPKLKDIYKIYNGETIYFCGEDFYTNINIENLKDMKLIPLTIPAELLLNRCINNISMKDNTMNFEILEKKQGIIKAKVIRGGIVRSGKGCNIPDLKRDIPFLSEKDKNDIRWSIEKDIDIICQSYVESKEDIEFLKEYINIEFSDYKKPEIWAKVETPKGIKNLKEIIKVTDNVVIGRGDLVPEAGLLEAVKLEDKAIEYIVKNNKNIIMATNLLNSMKNGSRASLPEVESIYNFIKKGVRGFLLAGETSIGKAPIKTIDFLNKAIIYYKAENTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH25</accession>
    <name>A0A386PH25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_12060</name>
        <name evidence="11" type="ORF">EI377_06885</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="QAS60483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE35090">
        <property type="protein sequence ID" value="AYE35090"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60483">
        <property type="protein sequence ID" value="QAS60483"/>
        <property type="gene ID" value="EI377_06885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="273"/>
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        <location>
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            <end position="299"/>
        </location>
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        <location>
            <begin position="25"/>
            <end position="308"/>
        </location>
    </feature>
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            <end position="557"/>
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            <end position="381"/>
        </location>
        <ligand>
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        </ligand>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="557" mass="61909" checksum="7B6A9F6D2E3CD223" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH34</accession>
    <name>A0A386PH34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl hydrolase family 25</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">LysM peptidoglycan-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12115</name>
        <name evidence="6" type="ORF">EI377_06945</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02980"/>
    <dbReference type="EnsemblBacteria" id="AYE35100">
        <property type="protein sequence ID" value="AYE35100"/>
        <property type="gene ID" value="CP523_12115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60493">
        <property type="protein sequence ID" value="QAS60493"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="223"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="385" mass="42388" checksum="31234C43E1734B7A" modified="2018-12-05" version="1">MQSISSENLKGIDVSSWQGLINFSEVKNSGIQVVYTKATEGTYYTDPFLKPNYSNAKAEGLYVGFYHYFKPESIDSSTKQAQYFASRISGLNPECKLVLDLEISGGFSSTELSNLAETFLVELKKLTGIDVAIYTYSNFARYNLTNILSKYPLWIAEYGVNTPMDNPIWTSWIGFQYSDSGYVPGVSGNVDLNVFTNDILLNTSITSPIIPAPNSPEISDNEIFYVVQPGNTLSQIASKYDTTVENLVNINNISNPNLIYPGEVLKIFINSINSSNDFNSIYVVQSGDTLSKIADNLGTSVNSIVNLNNISNPNLIYPGEILNIPSSISSNTGNSNNLAQSYIVQSGDTLSKIAQIFDTTYEHLAEINNISNPNLIYPGQVLKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK5</accession>
    <name>A0A386PHK5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PAS domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03835</name>
        <name evidence="9" type="ORF">EI377_14370</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675488.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01539"/>
    <dbReference type="EnsemblBacteria" id="AYE33659">
        <property type="protein sequence ID" value="AYE33659"/>
        <property type="gene ID" value="CP523_03835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61821">
        <property type="protein sequence ID" value="QAS61821"/>
        <property type="gene ID" value="EI377_14370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="194"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="318"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="636" mass="71946" checksum="3C1A509891BBCFB5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM4</accession>
    <name>A0A386PHM4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">D-alanine--poly(Phosphoribitol) ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06280</name>
        <name evidence="4" type="ORF">EI377_00755</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677756.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02415"/>
    <dbReference type="EnsemblBacteria" id="AYE34106">
        <property type="protein sequence ID" value="AYE34106"/>
        <property type="gene ID" value="CP523_06280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59473">
        <property type="protein sequence ID" value="QAS59473"/>
        <property type="gene ID" value="EI377_00755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
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        <property type="entry name" value="AMP-bd_C"/>
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        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
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        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
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        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="423"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="504" mass="57814" checksum="C66C0662F1F033CC" modified="2018-12-05" version="1">MMKNVLEYLECSAEKYPDKIAVKDAESSCSYIKLLENAKHIGSALLEYQLPRKPVIVFMHKSVEALNAFMGIISAGCFYVFINPDQPEPRIKQILEITKAKYIITHNEFIDTIKKVEFSGKLLEYNKIIETEINEEKLRNIRESALDIDPLYCNFTSGSTGVPKGVLVSHRSVIDFMEYFPDMFQITHDDIIGNQAPFDFDVSVKDIYSTLKVGATMVIIPKQFFSVITKLLDYICDEKVTTMIWAVSALCLITQLRGLTYKIPTSVNKILFSGEVMPIKHLKLWREALPKANFVNLYGPTEITCNCTYYRVDRDFEPNEILPIGKAFPNEKVFLISENNEEITEKEKIGEICVSGTAVALGYYNNEAQTSKAFVQNPLNTEYMEIIYRTGDLAVYNNDGDLCFAGRKDFQIKYMGHRIELEEIEATLNGYPDIDRACCIFDSDKNKIIAFYVGSMEKKEIQKKMRESLPIHMIPKTFYSMEELPMTQNGKIDRKKLRDYGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP9</accession>
    <name>A0A386PHP9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NusG domain II-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09985</name>
        <name evidence="4" type="ORF">EI377_04770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676552.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00326"/>
    <dbReference type="EnsemblBacteria" id="AYE34704">
        <property type="protein sequence ID" value="AYE34704"/>
        <property type="gene ID" value="CP523_09985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60105">
        <property type="protein sequence ID" value="QAS60105"/>
        <property type="gene ID" value="EI377_04770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="9"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="127" mass="14413" checksum="6E0B23D9374CF619" modified="2018-12-05" version="1">MIKKWDIIIIVLLMIMSFIPEFILGANLKAEHNNVYAEITISGKLYKNINLSSHKGEEIIEVNTKNGSNKIIIKDDKIGIYDADCPDKICMKPEFISSVGENLVCLPHRLMIEIKGVKEEEDMIISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV8</accession>
    <name>A0A386PHV8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11285</name>
        <name evidence="3" type="ORF">EI377_06095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02814"/>
    <dbReference type="EnsemblBacteria" id="AYE34947">
        <property type="protein sequence ID" value="AYE34947"/>
        <property type="gene ID" value="CP523_11285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60341">
        <property type="protein sequence ID" value="QAS60341"/>
        <property type="gene ID" value="EI377_06095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="121" mass="13611" checksum="6C3678C2790EFAD6" modified="2018-12-05" version="1">MNIKEMIQLKNWVVIGDVTNTSKYAYKILEKFKSKNYVVAGVHPKGGENVFKTLTEVPYKIDAIDLCVNPKLGLEILKEANLLGIKNILIQPGAESKEIIDYCREVSMNAIEDCALIQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ0</accession>
    <name>A0A386PHZ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03069"/>
    <dbReference type="EnsemblBacteria" id="AYE35703">
        <property type="protein sequence ID" value="AYE35703"/>
        <property type="gene ID" value="CP523_15385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="325" mass="36453" checksum="45832F5DAAFDCD50" modified="2018-12-05" version="1">MKIAFRGGHNEQATGASALIDELTEDRKVLAECINVARGYGHEVLDCTPGPCDVNTDLVYGVKKANEWGADIYIPIHFDKAYDNYNGALGTGTFVYSKSDAYKDEDIAQKISNNIAALGFKNRGVKEADYYDLRMTTMPAVLVEVCFCEATEDVALYRKLGARKIAEAIVSGITGKNIEQSVQSDIGMRVALDEPNHITIDSNKLKVRGWALNHAKLEILIDNVSYGTVETGQKREDVYEAYPQYNNHFAGYEKTLEFTELEKGQYKCTVRATDNNNKTIEVTKTFTASKTISNNNEIFKKENEILRKENKELKEKMSKIKNIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI10</accession>
    <name>A0A386PI10_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11495</name>
        <name evidence="2" type="ORF">EI377_06310</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673313.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34987">
        <property type="protein sequence ID" value="AYE34987"/>
        <property type="gene ID" value="CP523_11495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60380">
        <property type="protein sequence ID" value="QAS60380"/>
        <property type="gene ID" value="EI377_06310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="98" mass="10969" checksum="1433958005565C3E" modified="2018-12-05" version="1">MLSADKIKIIPRHRSLIEEIGGSEIVIRENRFISFISGSVTSNIIEGDTIVLQNTRCKVVRGHNITILEDCIIDKIEYTGILKVDKRSTVGESICLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI25</accession>
    <name>A0A386PI25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33819">
        <property type="protein sequence ID" value="AYE33819"/>
        <property type="gene ID" value="CP523_04695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="193" mass="22901" checksum="66B1B5C2E5E245D4" modified="2018-12-05" version="1">MAKPKIKNLYNRDRLALTSISKCGHVRESELKNFIADKRINNYVKDNLVTREVFNKNNGEQLVAYKLTKEGKKLLEREWGVKNHYNAQSINHDLGISNKYFSLSEDKRETWKTETELRQELEEKLQEIKTIDYERYQEINRMLEEKLISTPDGAYIDKETGIETYFEVITNSYGQTEIEAKERFIEIMDIKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI29</accession>
    <name>A0A386PI29_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="6" type="ORF">CP523_10650</name>
        <name evidence="7" type="ORF">EI377_05435</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876524.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01372"/>
    <dbReference type="EnsemblBacteria" id="AYE34824">
        <property type="protein sequence ID" value="AYE34824"/>
        <property type="gene ID" value="CP523_10650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60219">
        <property type="protein sequence ID" value="QAS60219"/>
        <property type="gene ID" value="EI377_05435"/>
    </dbReference>
    <dbReference type="GeneID" id="66302536"/>
    <dbReference type="KEGG" id="csep:CP523_10650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="103" mass="11353" checksum="052391D17216DBD0" modified="2018-12-05" version="1">MYAVLTTGGKQYRVQEGDVIYVEKLNAEVDSTVELTEVLAVSNGETLKVGAPVVEGAKVVAKVVAQGKAKKVTVFKYKPKKDYRKKTGHRQPYTKLVIEKIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI33</accession>
    <name>A0A386PI33_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">rplK</name>
        <name evidence="9" type="ORF">CP523_08910</name>
        <name evidence="10" type="ORF">EI377_03665</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4 6">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678829.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01781"/>
    <dbReference type="EnsemblBacteria" id="AYE34528">
        <property type="protein sequence ID" value="AYE34528"/>
        <property type="gene ID" value="CP523_08910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59930">
        <property type="protein sequence ID" value="QAS59930"/>
        <property type="gene ID" value="EI377_03665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="141" mass="14909" checksum="0D2A81B43B30228F" modified="2018-12-05" version="1">MAKKVTGMIKLQLAAGKATPAPPVGPALGQHGVNIMGFCKEFNAKTANQAGLIIPVVITVYQDRSFSFILKTPPAAVLIKKELGLESGSGVPNRTKVGKLSKDQVRKIAEMKMPDLNAATIETAMSMIEGTARSMGVTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI72</accession>
    <name>A0A386PI72_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate/gamma-aminobutyrate family transporter YjeM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yjeM</name>
        <name evidence="6" type="ORF">CP523_01375</name>
        <name evidence="7" type="ORF">EI377_11890</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675706.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35793">
        <property type="protein sequence ID" value="AYE35793"/>
        <property type="gene ID" value="CP523_01375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62212">
        <property type="protein sequence ID" value="QAS62212"/>
        <property type="gene ID" value="EI377_11890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="484" mass="53955" checksum="00CE758932CCE936" modified="2018-12-05" version="1">MIFTSVYGFNNIPRAFYLMGYSAIPWYILSAITFFIPYAFMMAEYGAAFRKEKGGIYSWMEKSVGPKYAFIGTFMWFASYLIWMVSVSSSIWVPLSNLIFGTDKTETWSLFGLNAPRTLAILGCIFIVLITFISSKGLKSIAKIASIGGVFVSSANIVLIIGALIVLVFNGFNMAQPISAAEFIHSPNPNYQTPLGILSFLVFALFAYGGLEAVGGLVDKTENPKVVFPRGIKIAALVIAVGYSLAILFVGFFINWKSILSSSNVNMANVSYIVIKNLGIELGRVFNLSPDNTVILGAWFARFIGLAMFLALTGAFFTLIYSPLKQLIEGTPSEIWPKRWTIKDENDMPVNAMWVQCIIVVSIILISSFGGKSAGVFLDYLILMGNVAMTIPYMFLSFGFIYFKRKKEIQKPFEIYKNPIVTNVTAIIVTFTVGFANFFTILQPALETKDYISTLFQLIGPLFFGFVGFLLYYIYEKKYIKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI99</accession>
    <name>A0A386PI99_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">V-type ATP synthase subunit K</fullName>
            <ecNumber evidence="8">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11990</name>
        <name evidence="9" type="ORF">EI377_06810</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673467.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02955"/>
    <dbReference type="EnsemblBacteria" id="AYE35077">
        <property type="protein sequence ID" value="AYE35077"/>
        <property type="gene ID" value="CP523_11990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60470">
        <property type="protein sequence ID" value="QAS60470"/>
        <property type="gene ID" value="EI377_06810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
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        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
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        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="161" mass="16739" checksum="676B1427AEC8FD42" modified="2018-12-05" version="1">MEMSWIKFFIENNGGFIFAAIGVALAVGLSGIGSAKGVGLVGQAATGLVTEEPEKFGKALVLELLPGTQGLYGFVIGFLVFSKMTSGMSLEQGMYLLGACLPIAFAGLWSGIAQGKVAAAGIQILAKRPEHNTKGIILAAMVETYALLGFVISFMLVSKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC0</accession>
    <name>A0A386PIC0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05115</name>
        <name evidence="2" type="ORF">EI377_15675</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676204.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33899">
        <property type="protein sequence ID" value="AYE33899"/>
        <property type="gene ID" value="CP523_05115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62050">
        <property type="protein sequence ID" value="QAS62050"/>
        <property type="gene ID" value="EI377_15675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7680" checksum="6DCD5F1ED4D1120E" modified="2018-12-05" version="1">MAVTKNLIKNTLKVGYEIGDKKKNQSFKNISSEASDENLVKLSDELDKIIEHSITSIKKEQVFEILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID0</accession>
    <name>A0A386PID0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MaoC family dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05175</name>
        <name evidence="3" type="ORF">EI377_15735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676225.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01824"/>
    <dbReference type="EnsemblBacteria" id="AYE33909">
        <property type="protein sequence ID" value="AYE33909"/>
        <property type="gene ID" value="CP523_05175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62060">
        <property type="protein sequence ID" value="QAS62060"/>
        <property type="gene ID" value="EI377_15735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="15156" checksum="0A563E18874372D9" modified="2018-12-05" version="1">MRGLRLNELKIGDKDFFQKTISESDVYLYAGITGDLNSAHINEVEAEKSMFKGRIVHGMLTAGLISTALGMKLPGPGTIYLGQELKFTAPVRFGDTIKAEIEVIEKNEEKNIIKLKTTCTNQDNKIVLTGIATAMPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK9</accession>
    <name>A0A386PIK9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TlyA family RNA methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TlyA family rRNA (Cytidine-2'-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15085</name>
        <name evidence="4" type="ORF">EI377_10040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676012.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01267"/>
    <dbReference type="EnsemblBacteria" id="AYE35650">
        <property type="protein sequence ID" value="AYE35650"/>
        <property type="gene ID" value="CP523_15085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61037">
        <property type="protein sequence ID" value="QAS61037"/>
        <property type="gene ID" value="EI377_10040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="269" mass="30245" checksum="764AB32CD6B5326B" modified="2018-12-05" version="1">MSAKKERLDILLVNKGIFTSRERAKTNIMAGKIFVDGHRVDKAGEKVNIDADIIFKGQEIPYVSRGGLKLEKAMKEFDINLEERVCMDIGASTGGFTDCMLQNGARKVFSVDVGYGQFAWKLRTDDRVVCMERTNIRYVTPEDIGEKLDFASIDVSFISLKKIMPATLNLLKDNGEVVALIKPQFEAGREKVGKKGVVRDINVHKEVVTNIVEFLISENINIIGVSYSPIKGPEGNIEYLVYFTKDKEKESNFTMEDIDRVVEASHEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN6</accession>
    <name>A0A386PIN6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">CP523_10160</name>
        <name evidence="14" type="ORF">EI377_04975</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676632.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00361"/>
    <dbReference type="EnsemblBacteria" id="AYE34738">
        <property type="protein sequence ID" value="AYE34738"/>
        <property type="gene ID" value="CP523_10160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60140">
        <property type="protein sequence ID" value="QAS60140"/>
        <property type="gene ID" value="EI377_04975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="25275" checksum="BA306C911B34E81D" modified="2018-12-05" version="1">MEPLKPIFSFGLGGFTVDITPDIVVQWVIIALVAILAWWATRNLKVKPSKKQVVVESIYTTIRNVVLENVGENYTDIIPFIGSMGIYLLLMNLVGLIGVVPPTKNFSVTLGMALITFFVVQTYAIKKHGVKSYMKGYIQPIPVMLPINLLERVMLPVSLSLRLFGNVLAATFIIELVYENLHKIAWIAQIGLPIALHGYFDVFDGVIQMVIFVMLTMINIKIVSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR9</accession>
    <name>A0A386PIR9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Methionine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_11615</name>
        <name evidence="8" type="ORF">EI377_06430</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02881"/>
    <dbReference type="EnsemblBacteria" id="AYE35011">
        <property type="protein sequence ID" value="AYE35011"/>
        <property type="gene ID" value="CP523_11615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60404">
        <property type="protein sequence ID" value="QAS60404"/>
        <property type="gene ID" value="EI377_06430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="22575" checksum="64DB0BC860247B6A" modified="2018-12-05" version="1">MIDILIPAFLETLIMVVLSTIFSLILGFIPAIILILTSPTGLRPNKVLYKTLDYIINILRSFPFIILMVSIVPITRFIVGKSIGTVAAIAPLTIAAAPFVARVIESSLKEVDSGVIEAAKSFGASDTQIIFKVMIKEAIPSIISGLTLTIISIIGYSAMAGAVGGGGLGDVAIRYGYQRYKIDVMVVTVIVLIVIVQGLQSLGNYLYKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT3</accession>
    <name>A0A386PIT3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">clpB</name>
        <name evidence="12" type="ORF">CP523_11720</name>
        <name evidence="13" type="ORF">EI377_06540</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673398.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02903"/>
    <dbReference type="EnsemblBacteria" id="AYE35031">
        <property type="protein sequence ID" value="AYE35031"/>
        <property type="gene ID" value="CP523_11720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60425">
        <property type="protein sequence ID" value="QAS60425"/>
        <property type="gene ID" value="EI377_06540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="417"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="866" mass="98067" checksum="E253682A30E450E4" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW1</accession>
    <name>A0A386PIW1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09330</name>
        <name evidence="2" type="ORF">EI377_04075</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678014.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34612">
        <property type="protein sequence ID" value="AYE34612"/>
        <property type="gene ID" value="CP523_09330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60012">
        <property type="protein sequence ID" value="QAS60012"/>
        <property type="gene ID" value="EI377_04075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029024">
        <property type="entry name" value="TerB-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158682">
        <property type="entry name" value="SSF158682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="139" mass="16543" checksum="34D59934C1DC6E1D" modified="2018-12-05" version="1">MFLNELNRELGIAYINLLIEFALVDDKVEQKERELIERSLKEMNLEKLELNKINREEIIEIIKNAGERVVNIVFFELTRVALADAEYEMDEVDFIDELAKEFNISRAKRFQMANYFFKHSEYDEINEDLAKKEAEAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ3</accession>
    <name>A0A386PIZ3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ORF">CP523_13745</name>
        <name evidence="5" type="ORF">EI377_08635</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677197.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02073"/>
    <dbReference type="EnsemblBacteria" id="AYE35407">
        <property type="protein sequence ID" value="AYE35407"/>
        <property type="gene ID" value="CP523_13745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60795">
        <property type="protein sequence ID" value="QAS60795"/>
        <property type="gene ID" value="EI377_08635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13745"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="325"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="452" mass="50909" checksum="1C9A0FCAF164F2FF" modified="2018-12-05" version="1">MKTISIKSVLSIIASKITIFLTKTILKGGTTFPGKVALKLDKNILSKVSKGYKVILVTGTNGKTTTTSMIYNIVKESGYKVITNNTGANLFPGIVTTFIDNYKFFNKTTDSYAIIEVDEANLKYITEYITPEIITVTNLFRDQLDRYGEVYTTLTKILDGVKLVPNSTLILNGDESLLGKLDIKNKTVFYGFNAAISENKEIDVNADAKFCKFCKSPYEYNHITYNHLGDFYCTGCGYKRSEIKYAVNEIIDLTAESSTIKFNNLPITVSQSGVYNIYNALCAYAITKELGIDDDTIKKSLENQSSSFGRQEILNIDGKDIKIILVKNPAGYNQALDTICLNKDSFSTAFLLNDNYADGRDVSWIWDVDFEKLHTLNIDEVFISGMRCYDMAVRLKIAGLDPNKFILEETFENLTEKIKTGSNNKIYVLATYTAMINFRKYLHSKGYIDKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ02</accession>
    <name>A0A386PJ02_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux RND transporter periplasmic adaptor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06360</name>
        <name evidence="4" type="ORF">EI377_00830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02431"/>
    <dbReference type="EnsemblBacteria" id="AYE34119">
        <property type="protein sequence ID" value="AYE34119"/>
        <property type="gene ID" value="CP523_06360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59485">
        <property type="protein sequence ID" value="QAS59485"/>
        <property type="gene ID" value="EI377_00830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="384" mass="42501" checksum="D5E25E0B4120AFB0" modified="2018-12-05" version="1">MKGSKIKSKKRLILISIGSIVIIAIVVALGFWVKAQNQSNGSSVEENTTEQFEITGNEGLSFKGVSVISKEQKIMADRTLGDIEGLNVSDKQEISEGDLLFTYSNQAILEEVKGVDRQIASANEKINRSKSKKAEISNEIAKYENELKGIKSKEMTPELEVKATELTQSIQAAQAKLEAEEATIATLKDSSGDLKLQKESLASKQNKEVKADINGIVYINEKGLTDPTVEYIRIVSKEPLIKAEVSEFDVESLKVDNEVQIKVVSNGDIVKGKIISIDELPTVSADGKGTSYNFYVKPEKAIRIGFSVEIKLNGEKIQIPKEYVYEEDSKLYIAKLKLDDKEEPFEKVEIKAELKGNNYSLIDGNVVAGDKLMKNPSELFKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ61</accession>
    <name>A0A386PJ61_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR02206 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11290</name>
        <name evidence="3" type="ORF">EI377_06100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673236.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34948">
        <property type="protein sequence ID" value="AYE34948"/>
        <property type="gene ID" value="CP523_11290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60342">
        <property type="protein sequence ID" value="QAS60342"/>
        <property type="gene ID" value="EI377_06100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011737">
        <property type="entry name" value="CHP02206_TP0381"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09529">
        <property type="entry name" value="Intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02206">
        <property type="entry name" value="intg_mem_TP0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="253" mass="29352" checksum="CF8BF0D82AE4CF77" modified="2018-12-05" version="1">MNFLREFFRTQPDRYVFDMFGITHIFILLITVLGCILIIHFKDKLREKSKFKNIIAIILLAQQIILYNWYIFSGYNTLREGLPLYNCRVAIISLAVGLLLNNKKLKVLAVYWGGFGTIFALLSPGTDPFSFPHYTKISYFLGHVLLAYGVVYILSVEEFKLNIKNLKGVLIFTNIYHSIVFFIDRIIGANYCYLINSPVALTKMSQFLYTFTVMMVFNLSIIVFYLIISKLSNRVLEENTLEDENTIRLITTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ70</accession>
    <name>A0A386PJ70_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="16" type="ORF">CP523_06940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01002"/>
    <dbReference type="EnsemblBacteria" id="AYE34209">
        <property type="protein sequence ID" value="AYE34209"/>
        <property type="gene ID" value="CP523_06940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06940"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE34209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="319" mass="35589" checksum="537D55D3D5808A8C" modified="2018-12-05" version="1">MGYCSELMEKILNGYEITKGEAIKLYNEPKEVLYKSADIIREIWAGSKVDLCSIINGKSGRCSEDCSYCAQSIHFKTGVTEYKLLSYEEIKAQAKENEIEGVDRFSIVTSGKGLVGEDFKLVVGYYKRLNDECNISLCASHGILDKESLMKLTEVGVKRYHHNLETSRSYYRKICTTHSYDERINTIKEAKKVGLEICSGGIIGLGESREDRIDMAIELRCLGVLSIPINALMAIKGTPLEKQESLSEEEILRTIAVFRFINPKANIRLAAGRSLLNNDGDRAFKAGENGTITGNLLTTCGNKICDDRRMIKSLGLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJA0</accession>
    <name>A0A386PJA0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoesterase</fullName>
            <ecNumber evidence="4">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09755</name>
        <name evidence="7" type="ORF">EI377_04555</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02657"/>
    <dbReference type="EnsemblBacteria" id="AYE34686">
        <property type="protein sequence ID" value="AYE34686"/>
        <property type="gene ID" value="CP523_09755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60087">
        <property type="protein sequence ID" value="QAS60087"/>
        <property type="gene ID" value="EI377_04555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="160" mass="17962" checksum="286AEB595D23C1D5" modified="2018-12-05" version="1">MKIAIISDSHYNDSSIKAIKNYIKDVDVLIHCGDGVPDVYKIAENFNGEVYGVQGNCDFSNEFPKERIIEIEGKRIFVCHGHFYNVKNGYNNIFFKAKELGVDIALFGHSHLGIILDNDGVLLMNPGSISLPYGDTKRSLGFIDIKNDKIIDAYLKEFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJD2</accession>
    <name>A0A386PJD2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_14745</name>
        <name evidence="10" type="ORF">EI377_09705</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676136.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01335"/>
    <dbReference type="EnsemblBacteria" id="AYE35587">
        <property type="protein sequence ID" value="AYE35587"/>
        <property type="gene ID" value="CP523_14745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60973">
        <property type="protein sequence ID" value="QAS60973"/>
        <property type="gene ID" value="EI377_09705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="8">
        <location>
            <begin position="36"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="346" mass="38583" checksum="5B88E33D5BC687BE" modified="2018-12-05" version="1">MKIIKKFIGFLPITLILTSLYSCNTNTKVIDKEIRIGVTLYKQDDTFISNIAKNIEELGKNKESSENSKITIDFEDAKGSPINQGNQVDKFINQGYDVICVNLVDRTAASTIIDKCKGANIPIIFFNRELVEEDMNRWDKIYYVGAKARQSGEMQGEIIVDEYNKNPLDVDKNGDGKIQYVILEGEPGHQDTTLRTEYCTKVIMENGIELEKLASDNANWQRGQGSTKMSQWINEFGNEIEVVFSNNDEMALGAIHALNSMNILTNKPLIVGIDGIKDALEAVKNGEMTGTIISDSLAQANAIFNIAYILSTGGDVNSIDGLDENRYIKTSHTKITIDNVDLYLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE9</accession>
    <name>A0A386PJE9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpsR</name>
        <name evidence="6" type="ORF">CP523_07560</name>
        <name evidence="7" type="ORF">EI377_02250</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673821.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01121"/>
    <dbReference type="EnsemblBacteria" id="AYE34309">
        <property type="protein sequence ID" value="AYE34309"/>
        <property type="gene ID" value="CP523_07560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59703">
        <property type="protein sequence ID" value="QAS59703"/>
        <property type="gene ID" value="EI377_02250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="80" mass="9398" checksum="F99B1091410968D9" modified="2018-12-05" version="1">MRDMKRSGKMRRSKRKVCAFCVEKAENIDYKDITKLRKFVTERGKILPRRISGTCAKHQRQLTSAIKRSRNIALLPFTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG9</accession>
    <name>A0A386PJG9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein CP523_10530</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yaaA</name>
        <name evidence="2" type="ORF">CP523_10530</name>
        <name evidence="3" type="ORF">EI377_05315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34802">
        <property type="protein sequence ID" value="AYE34802"/>
        <property type="gene ID" value="CP523_10530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60197">
        <property type="protein sequence ID" value="QAS60197"/>
        <property type="gene ID" value="EI377_05315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="255" mass="29756" checksum="7B6AF1C2B4339AC7" modified="2018-12-05" version="1">MLVVISPAKTLDFDYININTPMSEPRFLAKSKVIMDELKKLDAYSLSKLMKISDKLATLNRDRFEEWTENLDKAKQCLLAFKGDVYRGLDVGSFTEEDLFYADGHLRILSGLYGVLRPFDGINPYRLEMGTKIKVKDEKDLYKFWGNDLRDSLIKELSNHSEKVLINLASQEYFKSVEGIENISDVRVITPIFKEWRNGKYKIISLNAKRARGLMTRYIIQNQIDNVEIIKDFSEEGYTFSEEMSEDNQWIFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJH6</accession>
    <name>A0A386PJH6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAB</name>
        <name evidence="2" type="ORF">CP523_15015</name>
        <name evidence="3" type="ORF">EI377_09970</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676038.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01281"/>
    <dbReference type="EnsemblBacteria" id="AYE35637">
        <property type="protein sequence ID" value="AYE35637"/>
        <property type="gene ID" value="CP523_15015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61024">
        <property type="protein sequence ID" value="QAS61024"/>
        <property type="gene ID" value="EI377_09970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014198">
        <property type="entry name" value="Spore_III_AB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09548">
        <property type="entry name" value="Spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021435">
        <property type="entry name" value="SpoIIIAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02833">
        <property type="entry name" value="spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="172" mass="19745" checksum="2D7394F4F7C127D1" modified="2018-12-05" version="1">MLKIISILIIFLACTYIGFYYGENFKKRNSQLNEILKGILLLNNEVMYTNTPLPEAIRYVALKVDYPLRNLLLKVSENLVKGESKSVYEAFNEEYKKEKHNFKIIDEDKRVISDFLKSLGESGVYGQDKIFNLAIENIKVNCKVSELIASKNTKMYRVLGVCIGAMLSLFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI8</accession>
    <name>A0A386PJI8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanyl-tRNA editing protein AlaX-L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12105</name>
        <name evidence="6" type="ORF">EI377_06935</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673522.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02978"/>
    <dbReference type="EnsemblBacteria" id="AYE35098">
        <property type="protein sequence ID" value="AYE35098"/>
        <property type="gene ID" value="CP523_12105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60491">
        <property type="protein sequence ID" value="QAS60491"/>
        <property type="gene ID" value="EI377_06935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="398" mass="45269" checksum="834396307590EECB" modified="2018-12-05" version="1">MEKLYYTDQYIKSFTAEVIDVKELDGKFHVVLDKSAFFPGGGGQLGDIGYIENHKVMNVYEETGVLYHVVETKPIKIHKVKCSIDWKRREDGMHQHLAQHILSGCFFKLFNTNTVSIHLGKDISTVDIDGYFEESQIREAEVLANEIIGENLEVEFLTPTRKELKKLNLRRDLPKTNEEIRVVKIGDLDINACCGVHPKSTLDLRIIKIKKWEKHKKATRIEFLAGNRAVIDSLKKDRFASEVCKYLSSNEEEAINSIKNLNNNLKEVLDEKKRIEEEIARYEMKEMIETADKVKNISVVKKVYSGENIKYIQKLASKIVENEDTIALMVVKNGERANLIFASSKNIKNISMSDLLKDAITLIDGKGGGSLNLAQGAGKNNNNLEMTIEYAFNKLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJM5</accession>
    <name>A0A386PJM5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">minD</name>
        <name evidence="10" type="ORF">CP523_10605</name>
        <name evidence="11" type="ORF">EI377_05390</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674170.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01380"/>
    <dbReference type="EnsemblBacteria" id="AYE34816">
        <property type="protein sequence ID" value="AYE34816"/>
        <property type="gene ID" value="CP523_10605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60210">
        <property type="protein sequence ID" value="QAS60210"/>
        <property type="gene ID" value="EI377_05390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="5"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="265" mass="29181" checksum="44EAD58C14D46123" modified="2018-12-05" version="1">MGISIVITSGKGGVGKTTTTANIGTALATLGKKVVVVDGDTGLRNLDVLMGLENRIVYTLTDVIENRCRLKQALIKDKRYQNLCLLPTAQTKDKDDVRPQDMLKVVNSLKEDFDYVLIDCPAGIEQGFENSVVGADRALVVVNPEITSVRDADRVIGKLDAKGLEDHSVLINRLNYEMTQRGDMLDISDIIETLSIELIGVVPDDKNITVSTNKGEPIVLDDKSMSGQAFRNIAKRLTGEEVPLMDLREESEGFFASLKKLFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJM9</accession>
    <name>A0A386PJM9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ArAE_1_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03091"/>
    <dbReference type="EnsemblBacteria" id="AYE35464">
        <property type="protein sequence ID" value="AYE35464"/>
        <property type="gene ID" value="CP523_14075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021062">
        <property type="entry name" value="ArAE_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038323">
        <property type="entry name" value="ArAE_1_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11728">
        <property type="entry name" value="ArAE_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017287479" description="ArAE_1_C domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ArAE_1_C" evidence="3">
        <location>
            <begin position="146"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="322" mass="37358" checksum="78007678F28D7B64" modified="2018-12-05" version="1">MKYVYNLTFKMSISATVALALAGLLKLNFAPVAAVIAILSIQDTRKKALIVSRNRILACLIGLMVSVVLYKLLGQSPMVFGIFLIIFIPLTSKLKIEEGMIATVVLSTHLLIAENINLYWIVNELLIMLIGIGTAAIANLFMPSLEDKFKEDKDYIEEAFRIILFKMSKSLVTHTVDVDEGKLMDEIEEKLTDSKYTVYKIVNNKFLKTNSYYTDYINMRINQYDTIKRMRLHFDKFYMSFKQTTIMSNFIKEVAKNIKETNDCKELLRKLIILRNEFKKMDLPKTREEFENRSQLLQLLNDIEEFLEIKRNFAKSYLSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS3</accession>
    <name>A0A386PJS3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_11095</name>
        <name evidence="11" type="ORF">EI377_05885</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00921"/>
    <dbReference type="EnsemblBacteria" id="AYE34912">
        <property type="protein sequence ID" value="AYE34912"/>
        <property type="gene ID" value="CP523_11095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60306">
        <property type="protein sequence ID" value="QAS60306"/>
        <property type="gene ID" value="EI377_05885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="264"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="474" mass="54274" checksum="52362AA79BCC38E2" modified="2018-12-05" version="1">MKIKFKITLGISSILIILGIVLNISIRNVLISNLEKGVNSSLSELMNSTRETIKYRLTIDDSLLKEDLLRRESEYLIKYISLNYECRVEIQDMTGNTYSSNIINIYEEIENGISIARTGQAIINLKYTSYGMLGILSYPIYVNNRYLGILTIVKNYDSSYFEYIHTANFLTLIEIIIFIIIFLLCYFITNRTTKPISSLTSAVKEIGNGNYDISISTKGTDEVAILSQEFIKMKDKIQEQISTINAEKDKVFTLEKSRKQFFDNVTHEIKTPLTSISGYAEMIKDNITDDEEFKKRAIERIYSESERLHLLVLDLIDVSKGISNVQSPPDKIDMYPLIKQICEDMNIKAEKYNLKILYNLEIGSISGHQNKIRELLINILDNAIKHSIGIDDILVNSYIKENYYYIEVINKAVPIPDKIYNSIFDPFVKSPKSKELQSSGLGLYLCNEIIKEHFGEISIQNGETIIVKIKIPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS9</accession>
    <name>A0A386PJS9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminopeptidase P family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Peptidase M24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08465</name>
        <name evidence="4" type="ORF">EI377_03210</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01634"/>
    <dbReference type="EnsemblBacteria" id="AYE34459">
        <property type="protein sequence ID" value="AYE34459"/>
        <property type="gene ID" value="CP523_08465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59862">
        <property type="protein sequence ID" value="QAS59862"/>
        <property type="gene ID" value="EI377_03210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="139"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="358" mass="40490" checksum="7BF4A78598CBC815" modified="2018-12-05" version="1">MKETRIQNVLEAMEKQGLNQIIVTSAPSIFYLTGKWISPGERMIALYLNTNGSHKFIVNKLFPIYEDLGVDILWYSDIEDPINLLCTVVDKEKALGVDKTWPAHFLINLMNRNIVKGFVNSSPIIDRLRMIKDEEEIKLMKKSSNINDKVMKELWENFKEGYSEKYYSNLLAELYEKEGVNSFSFSPIIATSPNGADPHHKSGNSKLRKGQSIVIDMGGIYNYYCSDMTRTIFFGEAPTKEHEKIYNIAKEANLKAISKVKDGVKFSEIDKAARGHIEDAGYGEYFTHRTGHSIGIECHDFGDVSSVNNDEVKSGMIFSIEPGIYLKDNFGVRIEDLVLVTKNGCEVLNSVTKDITII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJT2</accession>
    <name>A0A386PJT2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR04540 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15720</name>
        <name evidence="2" type="ORF">EI377_10435</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35767">
        <property type="protein sequence ID" value="AYE35767"/>
        <property type="gene ID" value="CP523_15720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61105">
        <property type="protein sequence ID" value="QAS61105"/>
        <property type="gene ID" value="EI377_10435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030902">
        <property type="entry name" value="CLB_0814_fam"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04540">
        <property type="entry name" value="CLB_0814_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="80" mass="9435" checksum="4983B61CC825C852" modified="2018-12-05" version="1">MISNIRTFYKSQADLGYALRKYIDDYFDNKIPDVELRENISKIVEENKDKVFKEGDITKKLQQILGKNRLKILISIVKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK62</accession>
    <name>A0A386PK62_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAF</name>
        <name evidence="2" type="ORF">CP523_15035</name>
        <name evidence="3" type="ORF">EI377_09990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676028.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01277"/>
    <dbReference type="EnsemblBacteria" id="AYE35641">
        <property type="protein sequence ID" value="AYE35641"/>
        <property type="gene ID" value="CP523_15035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61028">
        <property type="protein sequence ID" value="QAS61028"/>
        <property type="gene ID" value="EI377_09990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014245">
        <property type="entry name" value="Spore_III_AF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09581">
        <property type="entry name" value="Spore_III_AF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02896">
        <property type="entry name" value="spore_III_AF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="193" mass="22159" checksum="2CDCD913173856BA" modified="2018-12-05" version="1">MDTLKNFIITLVTMLILMTAIELITPDNSMKKYLKFVLGLILISVMLTPIISLISKGEKQITNTIAKYGEEYSNTGEKIDKYKNDSREKAFTKNIEKNCEKILKDKFKNKDFKSEVVCKMDLENMTCSIDKVSIGVKDDSIKNVQKIEINTKDESSEALASDNEVEDEEVIKKYLKEVLNVHEDKIEIYSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI5</accession>
    <name>A0A386PKI5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eutJ</name>
        <name evidence="1" type="ORF">CP523_12455</name>
        <name evidence="2" type="ORF">EI377_07340</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675326.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02022"/>
    <dbReference type="EnsemblBacteria" id="AYE35166">
        <property type="protein sequence ID" value="AYE35166"/>
        <property type="gene ID" value="CP523_12455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60569">
        <property type="protein sequence ID" value="QAS60569"/>
        <property type="gene ID" value="EI377_07340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013366">
        <property type="entry name" value="EutJ"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02529">
        <property type="entry name" value="EutJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="30643" checksum="E60F73B0A0C8751D" modified="2018-12-05" version="1">MSEKRVNFEDCDNLVRKFEEVIENPILKESSVYYTGVDLGTACIVLAVLDENYQPVAGAYRYADVVRDGMVVDYLGAVKIVRELKEEIEEKLNTELIYAAAAIPPGTDALDSGAIKNVVQAAGFELTCLLDEPTAANAVLKIENGAVVDIGGGTTGISVLKDGKVVYVVDEPTGGTHFSLVISGAYKMPFKEADKFKRDNKNHKEILPLLKPVVEKVASIITTNVNNYDVKEISLVGGTCCLTGIEEIINKKTGIYTHKPKNPMFVTPLGIALNCTQDIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM1</accession>
    <name>A0A386PKM1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12670</name>
        <name evidence="3" type="ORF">EI377_07570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675208.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35206">
        <property type="protein sequence ID" value="AYE35206"/>
        <property type="gene ID" value="CP523_12670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60608">
        <property type="protein sequence ID" value="QAS60608"/>
        <property type="gene ID" value="EI377_07570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="40542" checksum="F81DFE07DF63BB9C" modified="2018-12-05" version="1">MKKQNIFIIVIFFIVSLFISLLFNIIENSYNYIKENNELLSNNAMELEISNANIDYKDLLNILNKTPEVYLEKNALSLDAYYGKMIYFNGNFKYTPPLINGEFLNHEIFNDLNGKYCVLGKRLTSLIKEKNNKKYVSINGEEYSVIGIMGYSNKESVFDERFYVNINPDILTNINGKWVIYGENVNGIYDIINVNAKKLDTDIKISLMSLDRPETSMMDLLSNKIYIIILFVLVVLTLLLNIVNVTNNYIIKRKKEFGIRRVYGATKMKIYFKIIYDYQVMAIEGFILSQLIYFLIIKFNKYEVIFGDKFNYLSAIFSFLVLLLIGIFISIIPIKKSNKLSPNESMKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP3</accession>
    <name>A0A386PKP3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10725</name>
        <name evidence="4" type="ORF">EI377_05510</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674120.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01357"/>
    <dbReference type="EnsemblBacteria" id="AYE34839">
        <property type="protein sequence ID" value="AYE34839"/>
        <property type="gene ID" value="CP523_10725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60233">
        <property type="protein sequence ID" value="QAS60233"/>
        <property type="gene ID" value="EI377_05510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788347" evidence="1">
        <location>
            <begin position="27"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="80"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="545" mass="61199" checksum="12C634A6261761A0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKR1</accession>
    <name>A0A386PKR1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Accessory regulator AgrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12085</name>
        <name evidence="4" type="ORF">EI377_06915</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02974"/>
    <dbReference type="EnsemblBacteria" id="AYE35864">
        <property type="protein sequence ID" value="AYE35864"/>
        <property type="gene ID" value="CP523_12085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62171">
        <property type="protein sequence ID" value="QAS62171"/>
        <property type="gene ID" value="EI377_06915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006741">
        <property type="entry name" value="AgrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04647">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00793">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="23700" checksum="9D76AB6CD089C52F" modified="2018-12-05" version="1">MGRLSQNIAERISQELNFESDKKEVIEYGIFAILQIILSIISVLIIGAFLNVMLESFITTITIALLRKYSGGAHASSPTRCTFIGTIISVAIPLMLKNVNDLNIVGIIVFLSFILSYYLVYKLAPVDSIFKPIKKEEKIKRLKKGSIIIVSIYLCLVLGNLIIYISTSYDKFIKYSLCICGGMMWQVISLTKLGHKLIYIIETFINKFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKV0</accession>
    <name>A0A386PKV0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4355 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13210</name>
        <name evidence="2" type="ORF">EI377_08055</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679063.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01962"/>
    <dbReference type="EnsemblBacteria" id="AYE35306">
        <property type="protein sequence ID" value="AYE35306"/>
        <property type="gene ID" value="CP523_13210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60695">
        <property type="protein sequence ID" value="QAS60695"/>
        <property type="gene ID" value="EI377_08055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025580">
        <property type="entry name" value="DUF4355"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14265">
        <property type="entry name" value="DUF4355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="23768" checksum="08529C9B8ADC5043" modified="2018-12-05" version="1">MLKKELLKLIEKAGDDENIDSLLENSNLAKSLQISGLTLEAFKEKIKSDKDFKAFLDSENDKYHSKALKTWRENNLEKELEPFIKEKYPDLITDPTQKKILELEKKLADEQKANARKDLLNEAMKYAKDKKLPASIIEKCLGDDFDKTKEVLDSIAEDWSKSLEAIATEKMKQSSYIPGNNSDGKPMSIGAAIAAQINNTSSAPSDPWTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKV2</accession>
    <name>A0A386PKV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2225 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00904"/>
    <dbReference type="EnsemblBacteria" id="AYE34929">
        <property type="protein sequence ID" value="AYE34929"/>
        <property type="gene ID" value="CP523_11180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018708">
        <property type="entry name" value="DUF2225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09986">
        <property type="entry name" value="DUF2225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="256" mass="29891" checksum="CAA0CCB5ECB546CA" modified="2018-12-05" version="1">MSNIFDGLQPFGFDNIDGKHLYNINNDIDIQKTDKEINHLFLKNIHCPVCENKFGTPSVKVNSPRVLSKDSDLFIRYYIINPYFYDVWVCPYCGYSAMKADFPKIRSYQIELVKERVTSKWKNREYGDVFTPEIAIERYKLALLNAMLMEGRNSTKAMICLKIAWMYRLLEDVINEKLFLEQAFIGLNEAFTIESFPMYGLDRFSTMFLLGELCRRTDKNSDALLWFSKVITSRGASQKVKEMARDGRDKIKEAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL41</accession>
    <name>A0A386PL41_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11895</name>
        <name evidence="2" type="ORF">EI377_06715</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673443.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35059">
        <property type="protein sequence ID" value="AYE35059"/>
        <property type="gene ID" value="CP523_11895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60452">
        <property type="protein sequence ID" value="QAS60452"/>
        <property type="gene ID" value="EI377_06715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="182" mass="20026" checksum="FA14A0AF8F93B3A8" modified="2018-12-05" version="1">MSKKKHRHKVEQCDCPNCRNNQKNNQGNNNPFGINPAQLMGLLGGMDMSQIGNMLSSMSRDGFNLNNLNLGAMQNMAGGNNNASGTNQGGFDISALQNIISKVGNGAGLNFNNLDFGSLQNMMGGNNVEKEDREEDLTNVFEDDISMDENIEFLRNIRSIVDPKRADFIDKVIEAYNNGSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLC4</accession>
    <name>A0A386PLC4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrimidine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">deoA</name>
        <name evidence="12" type="ORF">CP523_15155</name>
        <name evidence="13" type="ORF">EI377_10110</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:22824"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679001.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00097"/>
    <dbReference type="EnsemblBacteria" id="AYE35662">
        <property type="protein sequence ID" value="AYE35662"/>
        <property type="gene ID" value="CP523_15155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61049">
        <property type="protein sequence ID" value="QAS61049"/>
        <property type="gene ID" value="EI377_10110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="11">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="434" mass="46920" checksum="80A4BA1410EF1CA7" modified="2018-12-05" version="1">MRMYDVILKKRMGEELTKEEIEFFVNGYTKGEIPDYQASALLMAIFFNKMNKRETADLTMAMVRSGDEIDLSSIKGVKVDKHSTGGVGDKTSICLTPLVASLGAPVSKMSGRGLGHTGGTIDKLESFPGFTVELTEEQFINNSNDIGIAIMGQTGNITPADKKIYALRDVTATVDNRSLIAASIMSKKIASGSNAIVLDVKVGEGAFMKTPEDAKALAQAMVDIGTHCGRETIGVISDMDQPLGFAIGNALEVKEAIELLKGNGPKDLLELVLTLGSNMLVCGKIAKDFEEGKKLLMQNIENGKGLAKLKEFVAAQGGDASYVDDVEKLPKAKYVVEVKSEEEGFVSKIHAEEFGLIAMELGAGRATKESEIDLAVGIVLNKKRGDKVNKGDVLAYIHSNDENNIAKTSKKIKENFVITEKFENNIPLIYDIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLU3</accession>
    <name>A0A386PLU3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00355</name>
        <name evidence="4" type="ORF">EI377_10845</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678166.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00581"/>
    <dbReference type="EnsemblBacteria" id="AYE35786">
        <property type="protein sequence ID" value="AYE35786"/>
        <property type="gene ID" value="CP523_00355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62206">
        <property type="protein sequence ID" value="QAS62206"/>
        <property type="gene ID" value="EI377_10845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="29590" checksum="7A9852CABCE7267B" modified="2018-12-05" version="1">MSGIGRCSLTAVIPILSTLGIQCCPFPTAILSNQTEYSKFTFLDLTDNMKEYKNSWKGLDITFDCIYSGFLGSESQINIVSEFVKNNHDALIVIDPVMGDNGIIYDTYTKEMCSRLKELVKMADLVTPNLTEACILTEKDYNSIDITEKNLITIAKEIINLGPKKVIITGIISKNEIWNFAYDKELKESFIVRSNYNNKSYSGTGDIFTSIVVGMLLRGNSLKESIEKASKFIYKVIEFTSKYDTDTKEGIMFELFLRELIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLV5</accession>
    <name>A0A386PLV5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metal ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02880</name>
        <name evidence="6" type="ORF">EI377_13405</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677030.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00982"/>
    <dbReference type="EnsemblBacteria" id="AYE35806">
        <property type="protein sequence ID" value="AYE35806"/>
        <property type="gene ID" value="CP523_02880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62223">
        <property type="protein sequence ID" value="QAS62223"/>
        <property type="gene ID" value="EI377_13405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="25053" checksum="7267E6CE854F2065" modified="2018-12-05" version="1">MININNLCFSYTNKQPYLLNNINLSIPKGAYVSVIGENGSCKTTLIKLILGLLSPSSGSIENEATSIGYVPQRLDSFNAQFPITVFEVLDCHRKTLKSTKNINIESALKQVNMYNFKNTLLGNLSGGQQQRILIARALMGNPEILILDEPSTGVDEINQKEIYTVLNTLNKDKNKTIISIEHNINIAIRYSTHILKVHNGTINLYTVKDYIKVREQNSILDNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM55</accession>
    <name>A0A386PM55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679281.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01943"/>
    <dbReference type="EnsemblBacteria" id="AYE35709">
        <property type="protein sequence ID" value="AYE35709"/>
        <property type="gene ID" value="CP523_15415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="223" mass="25054" checksum="4E2E5C1BC04A8E1F" modified="2018-12-05" version="1">MFKHEKQLLRDVMVEKPNPQYAVLMQEQLGGGNGELKAAMQYMAQSFRIKDKEIKDLFLDIAAEELSHMEMVAQTINLLNGHDVDNCKVTSGEIQTHVQCGLSPVLINSSGAPWTADYVTVTGDLVADLLSNIASEQRAKVVYEYLYRQIDDKYVKETIDFLLNREEAHNALFREALNKVQNTGSNKDFGVTEDSKLYFDLSSPGVDHKSPNPTPPSFENPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMA5</accession>
    <name>A0A386PMA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02310</name>
        <name evidence="3" type="ORF">EI377_12830</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00505"/>
    <dbReference type="EnsemblBacteria" id="AYE35799">
        <property type="protein sequence ID" value="AYE35799"/>
        <property type="gene ID" value="CP523_02310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62219">
        <property type="protein sequence ID" value="QAS62219"/>
        <property type="gene ID" value="EI377_12830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010897">
        <property type="entry name" value="Spore_II_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07454">
        <property type="entry name" value="SpoIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02867">
        <property type="entry name" value="spore_II_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="352" mass="39430" checksum="70066D4FBC1C6A0D" modified="2018-12-05" version="1">MGRRKSKSKEGSKFNIGYILMIIAILVFFIRALGVVDKYYERGGYAYVQLLNFSMPIVETQVYNKEDFAENKLSIEKIIIQALGLGNINAQSIVGKELTLFKEVAGDCVQNKSIVGLTPFSLKDNSIAKLTPEEIAELNKVSDAYDPSLKKTLDNSKPEVLIYHTHTTENYAEAGKDTTDSNFNVVGVGDILAKELEEGYGISVVHDKTNHSIEYNDSYNRSNETVQKYLNKYGDFKLVIDLHRDSLDPGKKVTGSINGQELAKFMFVRAENSTRYEANKALSDKLYGIATSLYPEITRNIWTYEIGKNAFNQGLSDNSVLIEVGFNTNTAQEAKLTAKYIARVLAEHLNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAW6</accession>
    <name>A0A386PAW6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional oligoribonuclease/PAP phosphatase NrnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00660</name>
        <name evidence="4" type="ORF">EI377_11150</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676369.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00663"/>
    <dbReference type="EnsemblBacteria" id="AYE33065">
        <property type="protein sequence ID" value="AYE33065"/>
        <property type="gene ID" value="CP523_00660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61234">
        <property type="protein sequence ID" value="QAS61234"/>
        <property type="gene ID" value="EI377_11150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="324" mass="35547" checksum="41E93C9357EEE63A" modified="2018-12-05" version="1">MSLNDISKSILNSNKIGITYHASPDGDAVGSALALLNALRKLKKDAYLISKDTLSDNLKFLPLSEEATGNVDTPLENTTTVVVLDCGNFERISGNLKNFKGKIINIDHHISNDYYGDENYVDDSAAATAEVVFELLEYMGINFEEESEDILKIGQCLYTSLVTDTGAFRHSNVTFKTHTIAAKLKKVGVNNTLIHQNLFDNKSFEKVRLIGKALNNMELLLDKKVALIQIPKSYAEELGVELQDTSDIISFGLQIKGVEVAVLIKEIENGSKASLRSKSDFDVRNIAESLGGGGHVKAAGITLKGICMDEAKDRILEQIEKELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAY6</accession>
    <name>A0A386PAY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dprA</name>
        <name evidence="4" type="ORF">CP523_00760</name>
        <name evidence="5" type="ORF">EI377_11255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674633.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02368"/>
    <dbReference type="EnsemblBacteria" id="AYE33085">
        <property type="protein sequence ID" value="AYE33085"/>
        <property type="gene ID" value="CP523_00760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61254">
        <property type="protein sequence ID" value="QAS61254"/>
        <property type="gene ID" value="EI377_11255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="3">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="356" mass="40439" checksum="170144328DF8F03E" modified="2018-12-05" version="1">MKIDEKKEDYILWYVLSKISNKSKLVLLSKYKNEENIYNNIEDLIKNSLIREKSLDKMKLIRKDDVEIFHKYLKENQIGYITINSKDYPKELLSIEEPPYVLFYKGDLSLLNNRKIAIVGSRNCTNYGIEITKRITEELIKNSLAIVSGGANGIDSVAHKVAVSRGKTIAILGCGIDVIYPKNNTRLYKDIEKTGLIISEFLPGTKPFSYNFPRRNRIISGLSEAIIVVEASLKSGSLITVSFALEQGKDVMAVPGSVFQKYSLGCNKLIRDGAIVFTELEDLYTMLNIEQKNLTNNDENSIKSLILSVISDEPSHLDDIMERVKVDRKVLFELLFEMQNTNEIICLPGNYYAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB50</accession>
    <name>A0A386PB50_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">nrdR</name>
        <name evidence="10" type="ORF">CP523_01070</name>
        <name evidence="11" type="ORF">EI377_11565</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674473.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02305"/>
    <dbReference type="EnsemblBacteria" id="AYE33145">
        <property type="protein sequence ID" value="AYE33145"/>
        <property type="gene ID" value="CP523_01070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61315">
        <property type="protein sequence ID" value="QAS61315"/>
        <property type="gene ID" value="EI377_11565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="151" mass="17830" checksum="A226B048FB2575D1" modified="2018-12-05" version="1">MKCPFCSFEESKVVDSRSTDDNTTIRRRRECLKCNKRYTTYEKVEDIPILVVKRDLTRENFNKEKIINGLIIACQKRPVSRSQIEEIAVDIEKTISNKMITEVESKYIGEMVMNRLKKIDEISYVRFASVYRQFKDINTFLEEIKSLVSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB89</accession>
    <name>A0A386PB89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01325</name>
        <name evidence="2" type="ORF">EI377_11825</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675567.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33193">
        <property type="protein sequence ID" value="AYE33193"/>
        <property type="gene ID" value="CP523_01325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61363">
        <property type="protein sequence ID" value="QAS61363"/>
        <property type="gene ID" value="EI377_11825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="377" mass="43655" checksum="1D5E1763045C67AF" modified="2018-12-05" version="1">MDKDINKIQEDIVKADIRKADKMWKDMDENSSLDYHLDRMTKEELVKVASKYNIRGITSLKKADAVLKVKEGIINNIDLVLNLLDEEGIEYIEEMVSLNGRKNYKCSELIDANYFRNRGLMFTGMVDKKLNVILPNELIDILKDKLTTDLKKKAKNNTEIIKLFAGMVYFYGVLTFENFKELVKSYIDFEIKDMNIESLILNGEELGFDYQVEGNLAYHIDVEEPLLIIKEQESNEDINYLKIDKKTIIKASRPDFIEESKQGEKLEKVMGQLFVIDKKILKEEIDSFSIAIKNEVSLDEAVEVFLEAYEIESEEERIIFTGELEKLAKSIKRWTLKGHTENDIQNKKKTVVNEVRIGRNDPCPCGSNKKYKKCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBC0</accession>
    <name>A0A386PBC0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">cbiD</name>
        <name evidence="6" type="ORF">CP523_01480</name>
        <name evidence="7" type="ORF">EI377_12000</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00848"/>
    <dbReference type="EnsemblBacteria" id="AYE33223">
        <property type="protein sequence ID" value="AYE33223"/>
        <property type="gene ID" value="CP523_01480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61395">
        <property type="protein sequence ID" value="QAS61395"/>
        <property type="gene ID" value="EI377_12000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01480"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="361" mass="39608" checksum="92DD83A4196433A5" modified="2018-12-05" version="1">MTDLYIESGFKKLRCGYTTGSCAAAASKAATFMLYNNETLESIEIDTPKGITLNIRINSIKRENNSVIVSVIKDAGDDCDITNGIEIFAKAEKLDKGFKLLAAEGIGIVTKDGLFVKKGEAAINPVPRAEIEREVTSVVPDNAGVKITISIPEGVEIAKKTFNPRLGIEGGISILGTRGIVYPMSEEALKDSIKLEINQKAINRERLVLTFGNIGEKCSLEQGFKEEEIVIISNFVGFALECCANVKIKEVILVGHIGKISKIAYGCFNTHSRVCDVRLEVLALELTLLGVDKALVEEVLKQKTSEGAVKFLGEGYEALYKNIGEKIKARAELYTYGEMKVKPLIYYGFSDYHILYNSLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBR2</accession>
    <name>A0A386PBR2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_02295</name>
        <name evidence="5" type="ORF">EI377_12815</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674008.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PBR2"/>
    <dbReference type="STRING" id="1504.GCA_900092375_00508"/>
    <dbReference type="EnsemblBacteria" id="AYE33375">
        <property type="protein sequence ID" value="AYE33375"/>
        <property type="gene ID" value="CP523_02295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61545">
        <property type="protein sequence ID" value="QAS61545"/>
        <property type="gene ID" value="EI377_12815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="302" mass="34190" checksum="C0E7820E6B66BE3D" modified="2018-12-05" version="1">MNPLKIVSFDGGGIKGALSIRIFKRLCYQYPTLLDNIDLFAGTSTGSLIALSLASGLSVNEVDNLYSYEITSKIFSNPSFNLFKPKFSNKNLKSILLNYFPNNLTLKNLPKYVCIPSFNVNGFTKNQWEPVFFNNLTDNKTINYNIIDVALASSAAPTFFPSHKNFIDGGVVANSPTTISIFHCMNAFPNIDFKNDIKLLSIGTGDSPYKIKQSTSNWGIYKWSFHPFAKMHSPIVSLVMDGMCDLDDMYCNILLKNNYFRINPKVSKLIEMDDYNFVPYLKFLADNIDLSDLFEFIESKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC97</accession>
    <name>A0A386PC97_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03430</name>
        <name evidence="3" type="ORF">EI377_13955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02237"/>
    <dbReference type="EnsemblBacteria" id="AYE33583">
        <property type="protein sequence ID" value="AYE33583"/>
        <property type="gene ID" value="CP523_03430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61747">
        <property type="protein sequence ID" value="QAS61747"/>
        <property type="gene ID" value="EI377_13955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="370" mass="41769" checksum="ABD6B69508780B7F" modified="2018-12-05" version="1">MLKIMLNTFKILTKKKSFIIVSILLPAVFTIVFSYMLGQQTVYKIGIINNDNAEISEVIKNRIENIDGVKIENVKENEYESFLASREIELAIVIDKGFSEDVLKGKENSIKISSVSESDIKPVVKSIIEAESKNLYVLSKLAKGDLKKFKALEKEYRSNMPKYVLNEVNNSISVMQSLGIVIMIIFISGQVITRFILDDEENGTKDRILLSNISERNYFAGILTIFFICSSLTSIFYYSICKLLNFNFGMENSTYFLLILLLVNLLSVTFNLCIVSFIKNPNLASNLSVLVIMPTSMLSGAFWDFGFMPESMQRLGNLCPQRWAINAIEKLQEGSSFLEIIPMVLALIMLSIVLFLLSLVLSKAKNKMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCB5</accession>
    <name>A0A386PCB5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03495</name>
        <name evidence="6" type="ORF">EI377_14020</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677912.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02250"/>
    <dbReference type="EnsemblBacteria" id="AYE33595">
        <property type="protein sequence ID" value="AYE33595"/>
        <property type="gene ID" value="CP523_03495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61759">
        <property type="protein sequence ID" value="QAS61759"/>
        <property type="gene ID" value="EI377_14020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="332" mass="37288" checksum="5ADB22F55D3EF7C6" modified="2018-12-05" version="1">MRNVTMSDIAKEANVSKTTVSKVLNNKQISVSNETRKNIFEIAKRLNYVPNSVARSLSTRKTNTIGIILPDIENPFFSEMAKAIEENAESLGYNVILCNSYNKDEKEERYIRLLVSKLVDGVIFASGGNSEDSLNILRSNRVPFVVIDREIETIEKYSGVLCDNEQGIELGVNYLFNKGKRQIAFVAGEPKFQISKIRNESYKNIAKKLGVYNPDIICESEFSIEGGMKATEELLLRSKYIDAIFYSSDVMALGGMKYLIRNGYKIPDDISILGYDNINISSLSEPELTTIAQPIYSMGEEAFKLLIEIIGGSDKNQIIKLKTKLIERDSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCX1</accession>
    <name>A0A386PCX1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_03730</name>
        <name evidence="11" type="ORF">EI377_14260</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33640">
        <property type="protein sequence ID" value="AYE33640"/>
        <property type="gene ID" value="CP523_03730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61804">
        <property type="protein sequence ID" value="QAS61804"/>
        <property type="gene ID" value="EI377_14260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="213"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="370" mass="42113" checksum="3DD606CDB76365AF" modified="2018-12-05" version="1">MNFKELGINENIIKILKKAGIATPTEIQKKSIKEILNGRDIIAEAQTGTGKTLAFLLPIFENISLSSKGVQCLIITPTRELAIQITEEATKLKEGKEIGILAMYGGKDIGAQLNKLKGDIQIIIATPGRLLDHIKRKTVDLKKLKTIVIDEADQMLLMGFRNEIDLVMKERPKKVQTLCFSATMDSSVKKLAYRYMNEPKVISVKKEEITLENIRQQVVETTDRLKREALCEVLDKDNPFMAIIFCRTKRRADELEIVMHRRGYNCKVIHSDIPQNKRERIMKSFRNADIQYLIATDVASRGLDIGGVSHIYNYDIPEKVETYIHRIGRTGRAGEDGYTCLFVDPKDARLLGDIEKEIKFKIPRRTIIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD68</accession>
    <name>A0A386PD68_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1648 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04260</name>
        <name evidence="4" type="ORF">EI377_14785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33740">
        <property type="protein sequence ID" value="AYE33740"/>
        <property type="gene ID" value="CP523_04260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61897">
        <property type="protein sequence ID" value="QAS61897"/>
        <property type="gene ID" value="EI377_14785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1648" evidence="2">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18563" checksum="76FEB10581AC4018" modified="2018-12-05" version="1">MDKWNNKATYQKINRIVDIIGIALIISLVVITLVAWKNAPDIVPTHYNFSGEVDGYGSKNTMLILLPIVVIVYIPMAVLSKYPEVYNYCVDINPINKEKQYLMASTFIRIINVETVAMFFYVQLKMVMGMSSGSKNLSMAFLPISLIIIFGTIGIYIRKSIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD89</accession>
    <name>A0A386PD89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05430</name>
        <name evidence="3" type="ORF">EI377_15990</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677964.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33955">
        <property type="protein sequence ID" value="AYE33955"/>
        <property type="gene ID" value="CP523_05430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62106">
        <property type="protein sequence ID" value="QAS62106"/>
        <property type="gene ID" value="EI377_15990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="158" mass="18610" checksum="A74CD13F5B0F758A" modified="2018-12-05" version="1">MHYEQFIEGDNSKRLDLLNKIKILILAVAALVYIFLGITLAIITLLMYVAFNFLTLNLFVEYEYELTEDELDLSKIMSKKKRKLIKTINLRNAEYFKDASEFNPARYSDIKVSKLYSKKYENKEKQVVLINEEGAISAYELVLKDEIRKEVERIKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD99</accession>
    <name>A0A386PD99_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04415</name>
        <name evidence="5" type="ORF">EI377_14960</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33770">
        <property type="protein sequence ID" value="AYE33770"/>
        <property type="gene ID" value="CP523_04415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61928">
        <property type="protein sequence ID" value="QAS61928"/>
        <property type="gene ID" value="EI377_14960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="25376" checksum="57843B63603DB804" modified="2018-12-05" version="1">MRLLEILIILLKHNKITTKELSEHFNVSIKTIQRDLDKLSVLGIPITTKRGAEGGVILDGKYKLSRGVLTYEDYDALIFSLKLAESVFENVSILEVLNKLLLIDSEEVKNEFEKINKYVHIDIVDNKIKLESKICKIINKALGYNNLLSINIKEKIYEVEPLAYVVKVEGMFLYAYMNKEYWLIPIAAIDDVNLLNVEFTPKLINYKENSKVKKLELNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDA8</accession>
    <name>A0A386PDA8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1292 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02795</name>
        <name evidence="3" type="ORF">EI377_13320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676981.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00965"/>
    <dbReference type="EnsemblBacteria" id="AYE33467">
        <property type="protein sequence ID" value="AYE33467"/>
        <property type="gene ID" value="CP523_02795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61638">
        <property type="protein sequence ID" value="QAS61638"/>
        <property type="gene ID" value="EI377_13320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="117" mass="13258" checksum="D095FB5585AC9988" modified="2018-12-05" version="1">MCNENNCGCHDEENKCGCHSEGHDCGCDHDHNEGGCGCGEHEHEHFVVDLEDDNGNVISCPIIDAFEFENNEYILAQHPEEDSVYLFRSTEEGELIVPEEDEFDKVSKFYSEELANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDE0</accession>
    <name>A0A386PDE0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02140</name>
        <name evidence="4" type="ORF">EI377_12660</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674065.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00539"/>
    <dbReference type="EnsemblBacteria" id="AYE33344">
        <property type="protein sequence ID" value="AYE33344"/>
        <property type="gene ID" value="CP523_02140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61514">
        <property type="protein sequence ID" value="QAS61514"/>
        <property type="gene ID" value="EI377_12660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="261" mass="29367" checksum="1369B2264C30F15E" modified="2018-12-05" version="1">MKKVKDIMDEMEKLAPTYLKEDFDNVGLMVGDKNQKVEKVLIALDCTLDVIEEAKGLNVDMILTHHPLIFKKPNSITTETLLGKKIIELIKNNISLYSSHTNLDSAKEGLNKTIVEMLGFSSEELIEVNKKDSSAGLGRMVRLDKEIELETLVEIIKRKLNIKNLRVSMGKEMFKNIAIINGSGQDFIGKAVARGAHCIITGDTTYHYASDYKEMGISILDIGHFSSEWLVFLKAIEKVLVKFPEVEFIKSALVKDPYTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDF0</accession>
    <name>A0A386PDF0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">era</name>
        <name evidence="13" type="ORF">CP523_02190</name>
        <name evidence="14" type="ORF">EI377_12710</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9 10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674044.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00529"/>
    <dbReference type="EnsemblBacteria" id="AYE33354">
        <property type="protein sequence ID" value="AYE33354"/>
        <property type="gene ID" value="CP523_02190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61524">
        <property type="protein sequence ID" value="QAS61524"/>
        <property type="gene ID" value="EI377_12710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="12">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
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        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
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    <feature type="region of interest" description="G3" evidence="9">
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            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="9">
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            <begin position="120"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="58"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="296" mass="34127" checksum="2278CE468F7AC4EF" modified="2018-12-05" version="1">MFKSGFVTIVGRPNVGKSTLLNQIMGEKLSIVSNKPQTTRNNIQTILTGDDYQMVFVDTPGIHKPKHKLGEYMVSSAKDSIKEVDLVLFLINPEEEIGRGDKFIIETLKNQKAPVFLVLNKIDEFTQDRVAKTLEMYSKEFDFKEIIPISAIKGKNVDKLVELMIEKMPEGPKYYPDDMITDVQERFVVAEIVREKALRCLRDEIPHGIAVDIIQMKQSENGTYHIEVDMICEKDSHKGIIIGKNGQSLKRIGETARYEIERFLHSKVNLKIWVKVRKEWRDNQNLLKELGYKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDI0</accession>
    <name>A0A386PDI0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS sugar transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_04860</name>
        <name evidence="16" type="ORF">EI377_15375</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01703"/>
    <dbReference type="EnsemblBacteria" id="AYE33850">
        <property type="protein sequence ID" value="AYE33850"/>
        <property type="gene ID" value="CP523_04860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61996">
        <property type="protein sequence ID" value="QAS61996"/>
        <property type="gene ID" value="EI377_15375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="105"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="455" mass="47293" checksum="AAF8C0416BD8F01D" modified="2018-12-05" version="1">MTNQEIAKLLVDFVGGKENIKSVSNCMTRCRLELKDSSKADIQGIKNSEGALGVVEVKGQLQVIYGPGKSNKVTEEVKKIVGQPVVIGKEAVIKTKAELKEKNNTKFKNSLRKIGNIFIPLIPLFVACGLVLAINNIAGVYFGEVYKETTAAQIIGLIGNGVFAILPILVGVNAAKEFGSQMPMMGGVLGGILSSSALANINLFGKELTPGRGGIISVILVVLLASFVEKYCRKVVPDILDLFVTPLVTLTISVLAALFILQPVGGFISDGIGTIVAETVASDNMIVAIFSGALSGGLFLPLVMTGMHQALTPIHADLIANVGYTVLLPILATAGMAQVGATLAVVKKTKNKGLKKTAKNGLVPGFLGIGEPLIYGVTLPLGKPFLGACLGAAVGGATMAALKVGAVAMGVSGLPLALLISDGKMFVFLIGVLVSYIAGYIFTALLGFEDPVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDL8</accession>
    <name>A0A386PDL8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33890">
        <property type="protein sequence ID" value="AYE33890"/>
        <property type="gene ID" value="CP523_05070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="245" mass="28251" checksum="A27683D962F84802" modified="2018-12-05" version="1">MENRVRFINTYVNALTMDETLNKIEKYIINKEYVQHVVINASKINLMQQDSTLTEIINECPLINADGQSIVWASRILGNNVPERVAGIDIFTELVKISAEKGYKPYFFGAREEVVTKVVDTFKEMYPELKVAGYRNGYFNDEDSIKIAEDIRDSGADILFVAFSSPMKEYWIKEHMPIMKVPFAMGVGGSFDVVAGKTARAPKWMQKSGLEWFYRFVQEPRRMWKRYIIGNFKFIKLVLASKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDU6</accession>
    <name>A0A386PDU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00415</name>
        <name evidence="3" type="ORF">EI377_10905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678156.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33018">
        <property type="protein sequence ID" value="AYE33018"/>
        <property type="gene ID" value="CP523_00415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61187">
        <property type="protein sequence ID" value="QAS61187"/>
        <property type="gene ID" value="EI377_10905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="140" mass="16440" checksum="3037BC41A8DDFA33" modified="2018-12-05" version="1">MRFLRNAYGIDILSIFLIFLGSIFNIFNLTKILGLLFVLLAIFRCFSKNKYKRRDELDKFIFYLNKVLNKFGKSIPKSIPIIDFNSIYLLVNIFKQQRNKNKGYKITKCPNCKQKLRLPKGKGNIIVTCTKCKVKFDLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDZ2</accession>
    <name>A0A386PDZ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01570</name>
        <name evidence="2" type="ORF">EI377_12090</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675667.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33241">
        <property type="protein sequence ID" value="AYE33241"/>
        <property type="gene ID" value="CP523_01570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61413">
        <property type="protein sequence ID" value="QAS61413"/>
        <property type="gene ID" value="EI377_12090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="20714" checksum="929BE6B3FB54BFFE" modified="2018-12-05" version="1">MSCNKNKYPNNLDESVCEGDFERPTRNEKYEDIKENNCVSEKTVFSSCHMPECPNHSTHENGCDFDSVETISFKCCDIKERKNINVNIACTGRILNLNVFLKDVCVKNTVAVGILVCDKESDKIIGFKVKKVFIKPENNECCRDFFIGKFTFIIPEEDLCDNRLLKVKVLAQYTDIDWCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE05</accession>
    <name>A0A386PE05_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ORF">CP523_00775</name>
        <name evidence="15" type="ORF">EI377_11270</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674622.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02365"/>
    <dbReference type="EnsemblBacteria" id="AYE33088">
        <property type="protein sequence ID" value="AYE33088"/>
        <property type="gene ID" value="CP523_00775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61257">
        <property type="protein sequence ID" value="QAS61257"/>
        <property type="gene ID" value="EI377_11270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="87"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="272" mass="30664" checksum="99BE793351F9BBD3" modified="2018-12-05" version="1">MELLNTDISTLSYKIIKEKVDKLIIKDILKDDSLNILIKKLELDSRKNVQSLGSKIKKQKKKIEDEIIRVQNMYNFDKSFGSFKYVAGVDEVGRGPLAGPIVSAAVILDLNVLEEDLILGLNDSKKISKKKREELSEIIKKKALAYSIKEASNKEIDEKGIAYCNNKVFLEACNSVNIKPDLVLSDGYLIKNINIENKSVIKGDTKSACIAAASIIAKVYRDNLMKEYSIKYPNYGFEENVGYGTESHVKHIKEVGPCDIHRLSFLKNILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE32</accession>
    <name>A0A386PE32_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06040</name>
        <name evidence="7" type="ORF">EI377_00520</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01909"/>
    <dbReference type="EnsemblBacteria" id="AYE34060">
        <property type="protein sequence ID" value="AYE34060"/>
        <property type="gene ID" value="CP523_06040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59431">
        <property type="protein sequence ID" value="QAS59431"/>
        <property type="gene ID" value="EI377_00520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362702" evidence="4">
        <location>
            <begin position="34"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="5">
        <location>
            <begin position="166"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="279" mass="30295" checksum="17D5AE9CE9CBF5D4" modified="2018-12-05" version="1">MKKGILKKILGAAMVSVMAVGLIGCGNKGDSNKAEKDMLDVIKENGKLVVGLSADYAPYEFHAMIDGKDTVVGFDIDLAKEIAKDIGVKLEIKEMEFDSLVTALPADKIDMVISGMNPDEERKKVIDFSDIYYTSHHGVVVRGEDKNKYKKIEDLEGKKIGAQLGSTQSKLAQDKIKNVDLKQLSNVNNLILELKTGKVDALIVEVPVAEMAIKSNSDLVLGDIKFEEESGGNAVGIKKGSPKLVESVNNTIKRLTDSGELDKFIIDANNLSAEQAEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE59</accession>
    <name>A0A386PE59_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_07580</name>
        <name evidence="9" type="ORF">EI377_02270</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673830.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01125"/>
    <dbReference type="EnsemblBacteria" id="AYE34313">
        <property type="protein sequence ID" value="AYE34313"/>
        <property type="gene ID" value="CP523_07580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59707">
        <property type="protein sequence ID" value="QAS59707"/>
        <property type="gene ID" value="EI377_02270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="291" mass="32219" checksum="CB8A5EE0BE166052" modified="2018-12-05" version="1">MYNYLMFFGLEPIDGSLKLMIKWEEVENFIGKGIRIISILIIMYLTIKIGNKVIDKFIKRQIKSKLSFSMNEQKAITIGAVLKSALKYGVYLTGVAIIVANVFSGVSAAVLGAGGFAIGIGAQSLVKDLINGFFILFEDQYGVGDHISVGQYTGIVENIGIRTTVLRDFTGDLHVITNGSILEVTNHSRGDIRFIVDVEIAYEENIEAAISLITNVCNKFKVNNKEEIRGDIEVLGVTSLNASGVNIRVIGRAKPLSQWKMERELRKNIKEALDEEGIEIPYPKTQIIKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE84</accession>
    <name>A0A386PE84_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">CP523_01250</name>
        <name evidence="7" type="ORF">EI377_11750</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674357.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02268"/>
    <dbReference type="EnsemblBacteria" id="AYE33178">
        <property type="protein sequence ID" value="AYE33178"/>
        <property type="gene ID" value="CP523_01250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61348">
        <property type="protein sequence ID" value="QAS61348"/>
        <property type="gene ID" value="EI377_11750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="34038" checksum="B9BE6650AC59580F" modified="2018-12-05" version="1">MNKNIAFLFSGQGSQYVNMGKEIYDNIPECKEIFDRGEVILKMPIKDMIFNGPEEKLTLTENTQPAILLTSLACLKALEVNGIESNRIAGLSLGEYTALIYAGVISFEDGVKLIKERGRIMGSASNIGTMAAVLKLNDEKVNELLEKSREFGVIEGANYNCPGQVAIAGEFSAVKESIKIAKELGGIAVPLKVSGPFHSSLLKDASYEFLETLKKVKINKLEKVVYSNVKGSPYNENDDIKELLRKQMMSSVLFEKTIRDMIEEGIDTFVEVGPGKALRGFIKRIDKNVKVLNVEDMASLEATIKALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEE2</accession>
    <name>A0A386PEE2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06695</name>
        <name evidence="3" type="ORF">EI377_01160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679211.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00032"/>
    <dbReference type="EnsemblBacteria" id="AYE34180">
        <property type="protein sequence ID" value="AYE34180"/>
        <property type="gene ID" value="CP523_06695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59543">
        <property type="protein sequence ID" value="QAS59543"/>
        <property type="gene ID" value="EI377_01160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="35394" checksum="12295906707B2A9A" modified="2018-12-05" version="1">MKKVFRANLYFLIIILLEIFMPKILVPIYKEIGVTDIRIALAMNHILLFLVPATVYIILTKSSVKNTLKLNKLYFKDILLIILLAFLCQPIMSFFSIITAFFFNNEIGAFITQINSTPYLILLSLVALLPAITEECTIRGVVLSGYENKNMYLAAMVTGLFFGIFHLDPQQFLYTTVLGFILALVVRITNSIFASAIIHFIINGTSVTASKLLNSIPQSTTILEGNMDLSLRALPINEKMIMFVVYGVIALIFATFVYMIIKKLEELNIRRGVLTEERKEIIKDKDSIINIPFILIIVVYIAFMFYKYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEF1</accession>
    <name>A0A386PEF1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_08230</name>
        <name evidence="5" type="ORF">EI377_02980</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674709.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01588"/>
    <dbReference type="EnsemblBacteria" id="AYE34413">
        <property type="protein sequence ID" value="AYE34413"/>
        <property type="gene ID" value="CP523_08230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59818">
        <property type="protein sequence ID" value="QAS59818"/>
        <property type="gene ID" value="EI377_02980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="26099" checksum="F1DDBDB5425ACB74" modified="2018-12-05" version="1">MNEFLEVIGECSIFKKIKKEDIKNFIENSSYKLASYDKNDIIAVEGEDCNSIGIVVDGIIEIQNIYENGKNLTIKRFSRGDVFGEALVFSKQHIYPATIISVSKSKILFINKESIINFCFKDVDFLNNFMCLLSEKIIMLNNKIRNTSLKSIRQKISNFLLEQYNIREKTVINLNISKKEFAEILGIPRPSLSRELINMKDEGIIDLNKREINILDIDKLEEIMCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ3</accession>
    <name>A0A386PEQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DMT family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">EamA-like transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07410</name>
        <name evidence="3" type="ORF">EI377_02100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673784.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01091"/>
    <dbReference type="EnsemblBacteria" id="AYE34290">
        <property type="protein sequence ID" value="AYE34290"/>
        <property type="gene ID" value="CP523_07410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59684">
        <property type="protein sequence ID" value="QAS59684"/>
        <property type="gene ID" value="EI377_02100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="143" mass="15374" checksum="76DC79917D57F03A" modified="2018-12-05" version="1">MFAIICAIISGISMSLQGVFNTRLEEKIGTWETNAFVQATGLALTLIILFFFGKGNFKEIKDANKLYLLGGVLGVIIIFTVMKSIGAMGATCGIAIILVAQLTSAGIIDAFGLFGTDKIPFSMKEFIGIAIMIIGIVIFKWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES5</accession>
    <name>A0A386PES5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Germination protease</fullName>
            <ecNumber evidence="1">3.4.24.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GPR endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Germination proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spore protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpr</name>
        <name evidence="2" type="ORF">CP523_02315</name>
        <name evidence="3" type="ORF">EI377_12835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates the rapid degradation of small, acid-soluble proteins during spore germination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase action with P4 Glu or Asp, P1 preferably Glu &gt; Asp, P1' hydrophobic and P2' Ala.</text>
            <dbReference type="EC" id="3.4.24.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A25 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.78" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674002.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00504"/>
    <dbReference type="EnsemblBacteria" id="AYE33378">
        <property type="protein sequence ID" value="AYE33378"/>
        <property type="gene ID" value="CP523_02315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61548">
        <property type="protein sequence ID" value="QAS61548"/>
        <property type="gene ID" value="EI377_12835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00626">
        <property type="entry name" value="Germination_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005080">
        <property type="entry name" value="Peptidase_A25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03418">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019549">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01441">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5034628645" evidence="1">
        <location>
            <begin position="1"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034628646" description="Germination protease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="324" mass="35372" checksum="A54DF46EB6EF303B" modified="2018-12-05" version="1">MINVRTDLAIEARDMYTEENKKELDGVIVEEEKEDDIKITTVTIETDEAGEKLGKPAGNYITIDFPEFTHYDGESMDKVSKVVANVLRRLVDISEEKTALVVGLGNWKVTPDALGPKVTEKIMVTRHLKQVMPDAIDDSVRPVCCIAPGVLGVTGIETGEVVKSLVDKIKPDLVICIDALGSRKLERVNRTIQIGDTGISPGAGVGNHRMKINKDSLGVKVIAIGVPTVVDAATIANDTMDLLLDELIGKAETGKEFYNMLKSVDKIEKSALIKEILNPFVGDLMVTPKEVDTVIDSLSKIISNGINMAIQPNLDMEDINKFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES6</accession>
    <name>A0A386PES6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">CP523_08985</name>
        <name evidence="11" type="ORF">EI377_03730</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678354.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00237"/>
    <dbReference type="EnsemblBacteria" id="AYE34543">
        <property type="protein sequence ID" value="AYE34543"/>
        <property type="gene ID" value="CP523_08985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59943">
        <property type="protein sequence ID" value="QAS59943"/>
        <property type="gene ID" value="EI377_03730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="98" mass="11227" checksum="67A7987A2195EB8D" modified="2018-12-05" version="1">MKMTSHDIIRKPVITEKSMAAMAEKKYTFIVHINANKVQIKRAVEEVFGVKVENVQTLRTMGKTKRMGVHVGKRADFKKAIITLTEDSKNIEFFEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET7</accession>
    <name>A0A386PET7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">CP523_09035</name>
        <name evidence="10" type="ORF">EI377_03780</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678363.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00247"/>
    <dbReference type="EnsemblBacteria" id="AYE34553">
        <property type="protein sequence ID" value="AYE34553"/>
        <property type="gene ID" value="CP523_09035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59953">
        <property type="protein sequence ID" value="QAS59953"/>
        <property type="gene ID" value="EI377_03780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="86"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="20487" checksum="6793F0BFEB85704F" modified="2018-12-05" version="1">MTTRLQEKYEKEVVQAMIEKFGYKNIMEVPKLEKIVINMGVGEAKDNQKILEAAVNDLTIIAGQKPILTRAKKSVANFKIRENMALGCKVTLRKAKMYEFADKLMSIALPRVRDFRGVSSKAFDGRGNYSLGVKEQLIFPEIEYDKIDKVRGMDIIFVTSANTDEEARELLRFLGMPFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY2</accession>
    <name>A0A386PEY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_09350</name>
        <name evidence="5" type="ORF">EI377_04095</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678020.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34615">
        <property type="protein sequence ID" value="AYE34615"/>
        <property type="gene ID" value="CP523_09350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60015">
        <property type="protein sequence ID" value="QAS60015"/>
        <property type="gene ID" value="EI377_04095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788358" evidence="3">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="154" mass="18024" checksum="6B495579457C5F79" modified="2018-12-05" version="1">MKKFAIMTLILTIISGAVGCTNKKVEQPSIDKNQPQSSDQSSPQQNTSKNDSNSIEKAVEENKDNIKDLYEDLREELIKQKNNFDKEHWEEFSTEFNNEKEKIKNVVKDNYLNEAVRHLDELYTEYDTAIKEQKDINLERIESVKNKLEEIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC1</accession>
    <name>A0A386PFC1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">CP523_10275</name>
        <name evidence="18" type="ORF">EI377_05055</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674307.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01440"/>
    <dbReference type="EnsemblBacteria" id="AYE34755">
        <property type="protein sequence ID" value="AYE34755"/>
        <property type="gene ID" value="CP523_10275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60155">
        <property type="protein sequence ID" value="QAS60155"/>
        <property type="gene ID" value="EI377_05055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10275"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="123"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="241"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE34755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS60155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="391" mass="42839" checksum="F834339FA1E5BEE0" modified="2018-12-05" version="1">MRRLFTSESVTEGHPDKICDQISDAVLDSILAKDPNARVACETAVTTGMVLVMGEISTNCYVDIPKVVRDTIKQIGYDRAKYGFDCDTCSVLTSIDEQSGDIAMGVDEALESRQGDNDSVEAVGAGDQGMMFGFATNETEEYMPLPIAMAHRLSRRLSEVRKNGTLPYLRPDGKTQVTVEYDDNKVIRIDTIVISTQHGEDVTQEQIRQDLMEHVIRAVVPAELLDEKTKYFINPTGRFVVGGPQGDSGLTGRKIIVDTYGGAGRHGGGAFSGKDPTKVDRSAAYAARWVAKNLVAAGIADKLEVQLAYAIGVAKPVSISIETFGTSKKSDEEIALIVEKVFDLRPGAIIRDLGLRRPLYKQTAAYGHFGRNDLSLPWENLNKVEEIKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC2</accession>
    <name>A0A386PFC2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08810</name>
        <name evidence="3" type="ORF">EI377_03570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678093.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02703"/>
    <dbReference type="EnsemblBacteria" id="AYE34510">
        <property type="protein sequence ID" value="AYE34510"/>
        <property type="gene ID" value="CP523_08810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59913">
        <property type="protein sequence ID" value="QAS59913"/>
        <property type="gene ID" value="EI377_03570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="75" mass="8482" checksum="8B9E511634C9DC1A" modified="2018-12-05" version="1">MIKVYSTSACPWCVKAKSYLQSKNISFEELNVQDDMTAREEMIKKSKQMGVPVLDINGEIIIGFDKKAIDLALQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ2</accession>
    <name>A0A386PFQ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NPCBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01173"/>
    <dbReference type="EnsemblBacteria" id="AYE32999">
        <property type="protein sequence ID" value="AYE32999"/>
        <property type="gene ID" value="CP523_00300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017478214" description="NPCBM domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="NPCBM" evidence="2">
        <location>
            <begin position="922"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1411" mass="158132" checksum="FDF96A96E8AE31B9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR2</accession>
    <name>A0A386PFR2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsU</name>
        <name evidence="7" type="ORF">CP523_02230</name>
        <name evidence="8" type="ORF">EI377_12750</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003441547.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00521"/>
    <dbReference type="EnsemblBacteria" id="AYE33362">
        <property type="protein sequence ID" value="AYE33362"/>
        <property type="gene ID" value="CP523_02230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61532">
        <property type="protein sequence ID" value="QAS61532"/>
        <property type="gene ID" value="EI377_12750"/>
    </dbReference>
    <dbReference type="GeneID" id="65398196"/>
    <dbReference type="KEGG" id="csep:CP523_02230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="58" mass="6890" checksum="3C3FDFAC05B14421" modified="2018-12-05" version="1">MSEIKVGENETLESALRRFKRKCARAGVLSEVRKREHYEKPSVKRKKKSEAARKRKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ8</accession>
    <name>A0A386PFZ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33808">
        <property type="protein sequence ID" value="AYE33808"/>
        <property type="gene ID" value="CP523_04635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="313" mass="36813" checksum="5267EA1DCBE7F398" modified="2018-12-05" version="1">MKNNCEELLVRYNLILKAFEDHKEGRYHASVPLFLMIIDGAVNDYTKSKGFFAEGTDVSAWDCLVGCSSGLSKIKNIYCKGRKKTNTDVIYLPYRNGILHGRDLNYDNIFVSSKCIVLLFAIHDWMTNKKSEDSRRERFIEAQKPVSFKEIITQFNKNQEDKKIIDSWKPRIVTIGSTIPESGKYEEYNDYEYIQKVLKIFEYWDKKNYGQLSKILDKMFNYEKSQGLRPKLCKELFKNKELISYRLIEVEERAISLRRVLVEAKWESTNKIFIEDLEFGVVYQGEKDRPLLLNEKGGEWVIVPWKVQGLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG00</accession>
    <name>A0A386PG00_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">CP523_00885</name>
        <name evidence="9" type="ORF">EI377_11380</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674560.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02342"/>
    <dbReference type="EnsemblBacteria" id="AYE33109">
        <property type="protein sequence ID" value="AYE33109"/>
        <property type="gene ID" value="CP523_00885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61279">
        <property type="protein sequence ID" value="QAS61279"/>
        <property type="gene ID" value="EI377_11380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00885"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="158" mass="17670" checksum="574547ADCDA55536" modified="2018-12-05" version="1">MKVAVYPGSFDPITNGHLDIIRRGAKAFDKLIVAVLVNVDKKGLFSSEERVSLIKKVTKDLDNVEVLRFEGLLVDFARLNNSNIILKGLRTVSDFEYEFQMALMNSKLDSNIETVFMMTSSEYSYVSSSSVKQVAKFGGCIKGLVPDEIIPDIIDKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG86</accession>
    <name>A0A386PG86_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase archaeal subunit H</fullName>
            <ecNumber evidence="3">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ahaH</name>
        <name evidence="2" type="ORF">CP523_11980</name>
        <name evidence="3" type="ORF">EI377_06800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673465.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02953"/>
    <dbReference type="EnsemblBacteria" id="AYE35075">
        <property type="protein sequence ID" value="AYE35075"/>
        <property type="gene ID" value="CP523_11980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60468">
        <property type="protein sequence ID" value="QAS60468"/>
        <property type="gene ID" value="EI377_06800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014275">
        <property type="entry name" value="ATPase_A1A0-cplx_hsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02926">
        <property type="entry name" value="AhaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="108" mass="11924" checksum="A046402F71707789" modified="2018-12-05" version="1">MALEAIGEIKKAEAKAEELVSEATAKAKEIIRNANLEADKQYNEILEKAKAKKMKLMQDAQTEGDKEAEPILTKGEKEVQDIHNVSGAKKDNAINLVVERIVRIHGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB1</accession>
    <name>A0A386PGB1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpD</name>
        <name evidence="5" type="ORF">CP523_12020</name>
        <name evidence="6" type="ORF">EI377_06840</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673477.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02961"/>
    <dbReference type="EnsemblBacteria" id="AYE35083">
        <property type="protein sequence ID" value="AYE35083"/>
        <property type="gene ID" value="CP523_12020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60476">
        <property type="protein sequence ID" value="QAS60476"/>
        <property type="gene ID" value="EI377_06840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="24373" checksum="E6FF7C2A3354E6ED" modified="2018-12-05" version="1">MARLNVNPTRMEMSKLKKRLTTAVRGHKLLKDKQDELMRQFVNLVKYNNELRKSVEAELQGSLKDFVMASAVMSSEFLEEAVAYPKESISVEVGTKNIMSVNVPKMNFKRQLEGDEGSIYPYGFANTSAELDDAIGKLYGILPKLLELAEVEKSTQLMADEIEKTRRRVNALEYMTIPSLQETIKYIRMKLDENERGALTRLMKVKDMIEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC0</accession>
    <name>A0A386PGC0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flotillin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Flotillin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03425</name>
        <name evidence="7" type="ORF">EI377_13950</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02236"/>
    <dbReference type="EnsemblBacteria" id="AYE33582">
        <property type="protein sequence ID" value="AYE33582"/>
        <property type="gene ID" value="CP523_03425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61746">
        <property type="protein sequence ID" value="QAS61746"/>
        <property type="gene ID" value="EI377_13950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="PTHR13806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="5">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="193"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="491" mass="54806" checksum="58644DBA4F980B04" modified="2018-12-05" version="1">MQEMLIKFATIGVPILVVILIILSTWKKAPQDKAIVVTGLKRRVISGKGGLVVPFFEQTDRISLENMKVEVKTHESLDRNGVPIDTDGVAIIKVKSSSDGVLLAIEQFNTGKERETIEVIRGTVQDVLEGKLREIVSKMSIEEIYKDREMFANEVENVAKDDLERMGLEIKTFTIRDIDDTKGYLTALGAKQIAEVKKNASIAEAEAKKEEMQKTAEAKRLGTEAQIKAETEIARATKDKELKVQAYKEEEKKAQAKADFAYEVEKNIVQKQVIEARKNAELFEEQRQTEIAEQQARKKEMELEATIKKVAEADKYSEEQKAEADRYKLIKQAEAEAESIKIKGMAEADAIRLKGEATADAMKAEAEAMKEKAEAYKMYGEAAIIQMLADKLPEVAKYVSEPLGKTEKMVIIDNGNQGGASKVTKNITNIMAEIPEVINSLTGIDIIDLVKDLSKNKGNINNSDNNKVNEEIVIENIKEEQGEKVLNNKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD7</accession>
    <name>A0A386PGD7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Heavy-metal-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12185</name>
        <name evidence="3" type="ORF">EI377_07005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673562.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02992"/>
    <dbReference type="EnsemblBacteria" id="AYE35113">
        <property type="protein sequence ID" value="AYE35113"/>
        <property type="gene ID" value="CP523_12185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60504">
        <property type="protein sequence ID" value="QAS60504"/>
        <property type="gene ID" value="EI377_07005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7612" checksum="4FBA5D1F0A7D42F3" modified="2018-12-05" version="1">MERVHYNVSGLVNTMSKTHVKNALDNLEGVQQVCVDIGRGTVEVIYGEEANENEIRKCIENTGYIIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE1</accession>
    <name>A0A386PGE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glycine/betaine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_06200</name>
        <name evidence="6" type="ORF">EI377_00675</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679291.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02607"/>
    <dbReference type="EnsemblBacteria" id="AYE34091">
        <property type="protein sequence ID" value="AYE34091"/>
        <property type="gene ID" value="CP523_06200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59459">
        <property type="protein sequence ID" value="QAS59459"/>
        <property type="gene ID" value="EI377_00675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="320" mass="36604" checksum="BBDF35B5DBC2D0F4" modified="2018-12-05" version="1">MEVIRFKNIKKSYEKGRVIIDDLSFTIESGEFVTLVGKSGCGKTTLLKLINGIIKADEGNVIVEGKEISQWDIIELRRNIGYVIQQIGLFPHMSIGDNIAYVLNIKKTSKEEVDKRVRELINIVGISEDYLKKYPRELSGGQKQRIGVARALASNPDIILMDEPFGAVDEITRKSLQEEIKKIHKELKKTIIFVTHDIEEALKLGTKVVVLDKGKIVQYGTAKDMVFNVKNEFVKDLFGIKNFSSYLSFTKLSEVVQPISDDRKEYYEKMYRDKELPILIDDYTVMEAIKVLFENKYDKALVKNKQNVVVGQFSIGENYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF4</accession>
    <name>A0A386PGF4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated endoribonuclease Cas6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas6</name>
        <name evidence="2" type="ORF">CP523_01675</name>
        <name evidence="3" type="ORF">EI377_12195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675700.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00887"/>
    <dbReference type="EnsemblBacteria" id="AYE33259">
        <property type="protein sequence ID" value="AYE33259"/>
        <property type="gene ID" value="CP523_01675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61430">
        <property type="protein sequence ID" value="QAS61430"/>
        <property type="gene ID" value="EI377_12195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="28436" checksum="F395EA7EA8B2B80B" modified="2018-12-05" version="1">MRILVEIITEKIPLNNNRYLTLSLIKNVLEKQSPELFKAMYEDDENYNYRTKPFTYSLKLNDFKIVGDEFELKGNSTISISTPDPVLGSILYNGFLLTKEYEYNKKYKLSIGRVTLLKEKKVISNEVLFKTLSPLVIKNRRGEFLKIDNENYEKELNYIANKVLESYRGFGLKESLIFQPILMKKRVAKEKIEKFTKETNKDIFYITGYEGVFKLTGNKEDLNLIYNLGLGVRRSSGFGMLQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG3</accession>
    <name>A0A386PGG3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01730</name>
        <name evidence="3" type="ORF">EI377_12250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="23543" checksum="275232492A40D8AA" modified="2018-12-05" version="1">MKKILCYGDSNTYGYIPGTGERYTSKERWTGILQDLLGDGFCVIEEGLNGRTTVLDDPEDPFRNGAKYFEECIKLHYPIDLIIIMLGTNDLKLRFNATSSEIANGAGTLVKIALSTTEKESETNDSAEILLVSPIHVAETMNEEEFGYIRSHKISKELAPKYEKISKSLGVEFMNAALITEASKIDSLHLSKKGHKDLAKAFEKICREILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05510</name>
        <name evidence="2" type="ORF">EI377_00130</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
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            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="QAS59359"/>
        <property type="gene ID" value="EI377_00130"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="169" mass="18894" checksum="6A1A0CD197BB43D3" modified="2018-12-05" version="1">MGYLPEIANKIENGERFERIVDSIRGTKGVSKADNFTTIRKVTAEETNSWWKNVMGYDNPPYKPGTMVEEIKLTKDTTFVRVYDGEVSGIYGGWVMKAEDIAGLTPKQIQDKFALPSLPKYMADVKLTEGTTIRKGIVNPLEGWGNGGGIQYDLMGQRVGEFLNPRELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG9</accession>
    <name>A0A386PGG9_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">GHKL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06370</name>
        <name evidence="4" type="ORF">EI377_00840</name>
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    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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    <reference evidence="5" key="1">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 7534</strain>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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            <strain evidence="3">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02433"/>
    <dbReference type="EnsemblBacteria" id="AYE34121">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="21"/>
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        <location>
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        <location>
            <begin position="202"/>
            <end position="307"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34121.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS59487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="35772" checksum="B9B17E34A61DE7A8" modified="2018-12-05" version="1">MNIVVIFLEILISLLLYNNLINKNIFNNILKNVILALLSCVLFKIMYVFLYFIIFKIFNSSSLKINHMIIEFSIITSILLIISIHYYKASYLLLTEKKNVEINSYSNLVLEELIENIRLNEHEYKNHLNTLYSIIEVEDNKDIIKDKVEKYIGKIRAGNEITGILYIKNIIVKAIIYNKLLECNSLGIKLDYKINRDFNILLEDWELNIVLSNLLNNSIEAVKALENKYIEVKLDKSEDNLKSIIEIKNPIEDVNITEIEQFFKKGFSRKGKGRGYGLFNVKKIVKRNKGDITLTLQDECIILKIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH8</accession>
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        </submittedName>
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                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
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    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Leendertz F.H."/>
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        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="145" mass="16582" checksum="92A4A9D865089CC0" modified="2018-12-05" version="1">MPKKIRGKYNFGYADVNIEGIDKKEFFAHSGIKDIDSIENPLQREKLSNISIEPSQDKRVFDTLEVNERNEINGAGAWDRSRDTEFKILNELANKLGDNTKAYGKIKLYTDLDCCPSCKSVIKQFQERYPNINIEVIYKTKGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
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    <name>A0A386PGK2_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12665</name>
        <name evidence="3" type="ORF">EI377_07565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
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            <taxon>Clostridium</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675210.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01978"/>
    <dbReference type="EnsemblBacteria" id="AYE35205">
        <property type="protein sequence ID" value="AYE35205"/>
        <property type="gene ID" value="CP523_12665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60607">
        <property type="protein sequence ID" value="QAS60607"/>
        <property type="gene ID" value="EI377_07565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="372" mass="43576" checksum="A4B8AEC87808DB97" modified="2018-12-05" version="1">MFNIKFSFWELSKKIGFTIISIIQLAITFTFLYNIVYVKNQVSNTTEKVISTFSKDTIYTMDAFYGLDDIYDKKDADYLKFYNYLKNNKDIIHCTAYTDHVLLKTFENNNFLLTNNYAPIKEGHQYYPIKALKVDYNYINEFKYNIIEGQGLDKNDFSENRNEIPILLGINYKGIYNLNDKLEYYDYKYGKKNLIVKGFIDKGYNSIGKIIESKNVISLDNYIIFPIQNYTNTDDDFQVINSTLQSYLIINSNDVNSTLINIEENALKDFGEIKLTDINDNIKNYLEKYKIEEDILKVIFFIVFLMCFIGIMTNMINYINNNMKVFAINLLNGARILDIQLIVFYQIFIIVFSSLILSISGIHLLQSLNFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL1</accession>
    <name>A0A386PGL1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DegV family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein DegV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03955</name>
        <name evidence="3" type="ORF">EI377_14480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01561"/>
    <dbReference type="EnsemblBacteria" id="AYE33682">
        <property type="protein sequence ID" value="AYE33682"/>
        <property type="gene ID" value="CP523_03955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61839">
        <property type="protein sequence ID" value="QAS61839"/>
        <property type="gene ID" value="EI377_14480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="288" mass="31386" checksum="9FE7AB58E2A2F0B9" modified="2018-12-05" version="1">MGIKIITDSACDLPVKYIKENNIEIVSLTVNINGEFIPDDLGQTLKYDEFYKMIREGGMPSTAQVNVGTFEEVFKKYANKGDSIIYIGLSSALSGTFNSANIAMQSILDEYPNADISIIDSLSVSLGEGAIVYYICEMLKKGESKESVVKWAEDNKRKVIHAITVDDLNHLKRGGRISGATAAVGSLLGIKPTLILDNEGKVIPGAKIKGRKKAMRYLVQELKDKAVNIEEQVVFICHADCLKDAEELKEMILSEINVKDIMLNSIGAVVGTHGGPGTLATIFIGKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM1</accession>
    <name>A0A386PGM1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mac-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PGM1"/>
    <dbReference type="STRING" id="1504.GCA_900092375_01878"/>
    <dbReference type="EnsemblBacteria" id="AYE34028">
        <property type="protein sequence ID" value="AYE34028"/>
        <property type="gene ID" value="CP523_05875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015117">
        <property type="entry name" value="IdeS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09028">
        <property type="entry name" value="Mac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017214152" description="Mac-1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Mac-1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="418" mass="47620" checksum="A1F927A1BD43E208" modified="2018-12-05" version="1">MLKDSKIISAILLAGILSLIIPKTLTTYADSSALNYDSKYDLNNDSIINELDIDEISKYYNTEKDDPNWNSKFDFNNDGIIDIFDIIKISKLEGTSYVKKPSEKALALQNLLASNNNVTITKDEAGKSIYNVWVKGITPPAESDFTNLDLGFNCNMNVAPWKPGQGWYDINKLLDGSDNLLCSGAVAANMLHWWLDQNKDYIDKYLQQSPDNGKNSKKTLDVRTSSTFHNQTNSDIFNIIKRMFGAGPIWTDRALLWYINGFNMNFPTIPQYDSPHFDYRGGFFKDIFKKPGLTDRSYVGTYDLLNNRLLEWLKKDVALGISHKTIAVYDHIITLWGASFDEDGNIIGIYTTDSDDKDDEISKGVLYGMRYYKVVKDSNGRARLTTYNGKDINMGAKTVDLFSFSLERNQWEKYFNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ1</accession>
    <name>A0A386PGZ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="8">IMP dehydrogenase</shortName>
            <shortName evidence="8">IMPD</shortName>
            <shortName evidence="8">IMPDH</shortName>
            <ecNumber evidence="8 15">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 18" type="primary">guaB</name>
        <name evidence="17" type="ORF">CP523_09650</name>
        <name evidence="18" type="ORF">EI377_04430</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 14">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8 15"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676706.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02636"/>
    <dbReference type="EnsemblBacteria" id="AYE34667">
        <property type="protein sequence ID" value="AYE34667"/>
        <property type="gene ID" value="CP523_09650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60067">
        <property type="protein sequence ID" value="QAS60067"/>
        <property type="gene ID" value="EI377_04430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09650"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 8 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS60067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="483" mass="51822" checksum="348572A1435B17C0" modified="2018-12-05" version="1">MAKIIKTAYTFDDVLLVPNKSEVLPNQVSLKTKLTKKITLNIPLMSASMDTVTESKMAIAMAREGGIGIVHKNMTIEEQAKEVDRVKRQENGVITDPIFLAEDHTVREALALMAQYRISGVPVTRGSKLVGIITNRDIVFETNYDKAVSEVMTKSPLITSGEGTTLEEALEILKKHKIEKLPLVDEENNLKGLITIKDIEKAKAYPNAAKDEKGRLLCGASVGITKDMMERVDALVKVNVDVITLDTAHGHSKGVIDAVKAIKAKHPELQIIAGNIATAEATRDLIEAGADCVKVGIGPGSICTTRVVAGVGVPQLTAVMDCAEEGRKYGIPVIADGGLKYSGDIVKALAGGAAVAMMGSIFAGCDEAPGAVEIYQGRSYKVYRGMGSLAAMEKGSSDRYFQNGTKKFVPEGVEGRVAYKGYVTDTIYQLLGGIRSGMGYLGAATLEDLYETAQFVVQTSSGIRESHPHDINITKEAPNYSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH18</accession>
    <name>A0A386PH18_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05160</name>
        <name evidence="6" type="ORF">EI377_15720</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01821"/>
    <dbReference type="EnsemblBacteria" id="AYE33906">
        <property type="protein sequence ID" value="AYE33906"/>
        <property type="gene ID" value="CP523_05160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62058">
        <property type="protein sequence ID" value="QAS62058"/>
        <property type="gene ID" value="EI377_15720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="227" mass="25064" checksum="ED986C141D71C9E5" modified="2018-12-05" version="1">MNLLEVKSISKTYGSGESAVHALKDATFSVPKGEFVAIVGESGSGKSTLLNMVGALDTPSSGKVFIDGKNIFAMKDSNLTIFRRRNIGFIFQGFNLIPELSVEQNIIFPLLLDYQKPDKKYLEELLTVLNLKERRHHLPSQLSGGQQQRVAIGRALITRPSLILADEPTGNLDTQNSSEVITLLKEAAKKYEQTIVMITHSRSISQTADRILQVSDGVLTDFGRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH50</accession>
    <name>A0A386PH50_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">radA</name>
        <name evidence="8" type="ORF">CP523_08830</name>
        <name evidence="9" type="ORF">EI377_03585</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678101.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02706"/>
    <dbReference type="EnsemblBacteria" id="AYE34514">
        <property type="protein sequence ID" value="AYE34514"/>
        <property type="gene ID" value="CP523_08830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59916">
        <property type="protein sequence ID" value="QAS59916"/>
        <property type="gene ID" value="EI377_03585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="68"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="353"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="455" mass="50418" checksum="8E0CC1C19B11A8F8" modified="2018-12-05" version="1">MAKIKSIFVCQECGYESLKWLGKCPDCNKWNTMVEEVKNTQKEQKSKINTIKVLGSMPKNIQEIKSGEKERFNTGLKELNRVLGGGLVKGSLTLISGDPGIGKSTLLLQTANNIAKNYGKVLYVSGEESEEQIKIRGDRLGVNENNLYVLSETNLDLIEGYINELNPVFVIIDSIQTVYKEAVTSAPGSVSQVKECSNAIMRIGKSKNIPLFIVAHVTKQGELAGPRVLEHMVDTVLYFEGERTEEFRVLRTMKNRFGTTSEIGVFEMVEEGLKEIYDPSRIFLEDTNFNQEGSAVIGLMEGTRPILVEMQALVSETNMHMASRTAVGIDNQRLRLMLAVLEKKLKAPFFKYDVYVNVVGGLNLDGTTGDLGLALALLSSLKNTGFKLERAVIIGEVGLTGEIRPIASCDRLIKEAEKMGFKNAIIPNRNKDKVTSNEINIIGVSNIREAINKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH62</accession>
    <name>A0A386PH62_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13920</name>
        <name evidence="3" type="ORF">EI377_08815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678802.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00151"/>
    <dbReference type="EnsemblBacteria" id="AYE35435">
        <property type="protein sequence ID" value="AYE35435"/>
        <property type="gene ID" value="CP523_13920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60823">
        <property type="protein sequence ID" value="QAS60823"/>
        <property type="gene ID" value="EI377_08815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase2" evidence="1">
        <location>
            <begin position="22"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="259" mass="29461" checksum="767C9A43C7FF4EED" modified="2018-12-05" version="1">MKEIKKYLESRIGTYGFFFEDLKSGFIYGYNENVQMIAAGCMKLPIAVSLISAVEQGKVDFMDKIKIDGKDKVYGTGIIHEFNEREYTVFELLVAMLIQSDNTAANKIIDIVGMEQINKDIQKMGLKNTFLNRKTTDERKPKNEVENITTASDLSKIWKHLYEGTFLNADNSQMLVDILRRQQIKNKSALYIPDDLKYEISSKTGDKSGVENDTALIQLSKGNFVFTILSMSIPNSVYGTVTLAKCGKMMWDNVMNNWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB4</accession>
    <name>A0A386PHB4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-type HAD-IIB family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sugar-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03340</name>
        <name evidence="2" type="ORF">EI377_13855</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.23" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677207.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02116"/>
    <dbReference type="EnsemblBacteria" id="AYE33569">
        <property type="protein sequence ID" value="AYE33569"/>
        <property type="gene ID" value="CP523_03340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61732">
        <property type="protein sequence ID" value="QAS61732"/>
        <property type="gene ID" value="EI377_13855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="29673" checksum="F2DF1342A0B12E05" modified="2018-12-05" version="1">MYKLIALDMDGTLLKEDKSISERTKLAIQKAREKGVTVVLATGRPIEGVSRYLEELDMYKDSDYVLSYNGALVQKTKSKEVVSKVSLKGEDVHHLYKLSKENGVNIHAFSEIQGLITPKTSKYTEVEATINGINIKETDFDAIDKNEVIAKVMMIDEPELLSPTAENLPKEIYEKYTVVKSTPYFLEFLNKDANKGTGLELLAKHLGIKKEEVIAMGDAGNDLHMIEYAGLGVAMGNAFEEVKKAANYITSTNEEDGVAEVIEKFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB9</accession>
    <name>A0A386PHB9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03100"/>
    <dbReference type="EnsemblBacteria" id="AYE35473">
        <property type="protein sequence ID" value="AYE35473"/>
        <property type="gene ID" value="CP523_14120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="268"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="409" mass="48062" checksum="F771A17C426E1F7A" modified="2018-12-05" version="1">MIVIINGAFGVGKTSVAKRLVKNIPNSMMYNPEEIGFMLRNIIPDEIINYEEKAESFQDLDLWKKLVINIAKELINKYKKNLIIPITLRNHKYFNHIYHGLSLIDSEVYHFCLTASIETIHKRLLKRGDKPGTRCFNETLNCVEAFKHIEFKEHIDTENLNLDNVEDIILEKIKKLRNSLIRSEYLSKREYSIKAKNVDLKLLNSSHQSVTHIYKKKPYYEINLQTHPLIIQQELDIYDLSKYIVNLRIKDIDSEKLNRLVNSLSFFEKEKYKMIEKVLNYTRTMNFSKKVAEEMFNSKDNKNDIKSVLKDEDNCIQSTNIFIAIVRRLNIPAKFILGKISNDCYHTWAEIFIEKVGWIPVETQICIPIDVNKGYFGITNKHIKICEGVNFEDISKKHFKFDFEIKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC2</accession>
    <name>A0A386PHC2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679080.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33996">
        <property type="protein sequence ID" value="AYE33996"/>
        <property type="gene ID" value="CP523_05700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028964">
        <property type="entry name" value="Imm8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15586">
        <property type="entry name" value="Imm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="108" mass="12723" checksum="D0C040043A47F441" modified="2018-12-05" version="1">MKLEIKAYNVINEIWDDIDDFFLSCQIDIGFKDEIGAEIYSFDIVSPKKLQKMLVRDGVEIGKGYFIMNDYNKNSVCDKIGKLIDREISEENKYDVFDEISVYFREQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF2</accession>
    <name>A0A386PHF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03565</name>
        <name evidence="7" type="ORF">EI377_14090</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677742.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02232"/>
    <dbReference type="EnsemblBacteria" id="AYE33609">
        <property type="protein sequence ID" value="AYE33609"/>
        <property type="gene ID" value="CP523_03565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61773">
        <property type="protein sequence ID" value="QAS61773"/>
        <property type="gene ID" value="EI377_14090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="256" mass="28509" checksum="7E5BC9F27BF299F6" modified="2018-12-05" version="1">MTKEVLKVSNIEKYYGRKGNITKAINNISFLVEEGEFVGVMGASGSGKTTLLNCISTIDKVTSGHIYISGKDITTLSSKSLSKFRRDKLGFIFQDFNLLDTLTVYENIALALTILKVNHKDIDNKVKDVCKKLNINEILNKYPYEISGGQKQRVASARAIITNPSLILADEPTGALDSKSAKMLLESLENLNKNLNATIMMVTHDAFTASYANRILFIKDGKIFNELIRGNDSRKEFFNKIIEVITLLGGDQRDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI3</accession>
    <name>A0A386PHI3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03725</name>
        <name evidence="4" type="ORF">EI377_14255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33639">
        <property type="protein sequence ID" value="AYE33639"/>
        <property type="gene ID" value="CP523_03725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61803">
        <property type="protein sequence ID" value="QAS61803"/>
        <property type="gene ID" value="EI377_14255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="315"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="381" mass="44283" checksum="24DBA5D1863EDB32" modified="2018-12-05" version="1">MAITVEEALELQILDGFEVIAGKNGLSKKITNVAVWDYETGSLIKENFRAGDFALSTLVAIKDNIDELYGSVERMIEVGITCLAIKNIYFDYIPEEVIKLADKNDFVLMLFRDTFTEDVIVEVNKAITIKKQYENLALQIDKILYDNLNEETIKKLAYNININFKENNIVAYCKKKNNKLIGLREFSHEEMQDAYSRVIHYKGGYLVINTFNDIDSDEVENIILRRLEWLGFSPKEYVIGVSNLHYKIADLDKSIQESLYAFKHSKTYNKETSFFRKIGLNRIFIPILDNPWVQKYYNEVIEPLIQYDKSNDTELVRTAIKYIENNGDIKTTAEELFQHGNTVRYRIDKINKIISAHCKNEHFYEELAVGVRIYTLLNNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ5</accession>
    <name>A0A386PHJ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1700 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06120</name>
        <name evidence="4" type="ORF">EI377_00590</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01924"/>
    <dbReference type="EnsemblBacteria" id="AYE34076">
        <property type="protein sequence ID" value="AYE34076"/>
        <property type="gene ID" value="CP523_06120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59445">
        <property type="protein sequence ID" value="QAS59445"/>
        <property type="gene ID" value="EI377_00590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="253" mass="28113" checksum="48670CFE9A7BEE3D" modified="2018-12-05" version="1">MNKKMFLDILRTGLSDFPTGVLGDILYEYKDYFDVGIADGKTEEEIISELGSPYDIIDKYRKGHLKEYNPIKDSSNNYENHDFIDAEYSSSTENTHYDNLNYENTQTFNTEDTTSYSDESNSQTKSKSNGRNSNNIIITLIILLLGGIFFGPLFLGLTLGGLGALVGMLAGSFALSLAGIGILFGKVVSNTIGIIVFPSFILDFPNSVLILMVIGCILSFILLILIAYYLIKWCFRLLSKLIELITSKVKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM2</accession>
    <name>A0A386PHM2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_10920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677646.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34877">
        <property type="protein sequence ID" value="AYE34877"/>
        <property type="gene ID" value="CP523_10920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="334"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="474" mass="53801" checksum="666092CA9ECD727A" modified="2018-12-05" version="1">MENILNKLKSTAILNVFKYSMVKYIALAFVFFREIVNAKILGPEMVGILGNLILIISYCGYANLGVVYAMNREWIVYKDNEGESDKAREVINTSFSALSIVSLIFLLASISSIFIFEGISKWYMSLLFIIAITEQYKNFFINYFRLLNNLNMINLIELLNGIGTLILILLLGGSFKILGVLFAMTIIGIVIFLVSIIKVPKINIKINKEILKTLISIGIPLLIYNLGFYILTTIDRFVIIKFLGNEALGYYTFANQMATATLVFISSILFLFYPKMISKYNSGDNSEIINSIYSYTGLIELFNIVFIFIGVIVIKPFIDIILPNFKGSISTYNILLMAIIMSNFSYFSNVFIIAKKKQNVLVVLQILSIIINLLLNILGVKLNLGIIGVAIATLITNTIYSFIQHYIVNYKIRKSNFIKDLFKMYSGMIIISTYLVTVVIVDLNYMKIVLGLFIIMLLMIPKFFNIKKLIDDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM9</accession>
    <name>A0A386PHM9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS mannose/fructose/sorbose transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_03940</name>
        <name evidence="10" type="ORF">EI377_14465</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675524.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01558"/>
    <dbReference type="EnsemblBacteria" id="AYE33679">
        <property type="protein sequence ID" value="AYE33679"/>
        <property type="gene ID" value="CP523_03940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61836">
        <property type="protein sequence ID" value="QAS61836"/>
        <property type="gene ID" value="EI377_14465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00001">
        <property type="entry name" value="PTS_IIB_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.35.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004720">
        <property type="entry name" value="PTS_IIB_sorbose-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036667">
        <property type="entry name" value="PTS_IIB_sorbose-sp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03830">
        <property type="entry name" value="PTSIIB_sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52728">
        <property type="entry name" value="SSF52728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51101">
        <property type="entry name" value="PTS_EIIB_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-4" evidence="8">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18187" checksum="D11D9019173C45D3" modified="2018-12-05" version="1">MSNVNIEMMRIDQRLIHGQGQMWLNALGVNTVIVADDEASEDKIQQTLMKTVVSKSIAMRFFSIAHTCEIIHKASPKQKIFIVCKTPEDALKLVAGGVPVKEINIGNIHNAEGKTQVTRSIYLGKEDKAALKELSQKYDIKFNTKTTPSGNDGALQVDITKYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV3</accession>
    <name>A0A386PHV3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA</name>
        <name evidence="3" type="ORF">CP523_15165</name>
        <name evidence="4" type="ORF">EI377_10120</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ScpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679000.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00095"/>
    <dbReference type="EnsemblBacteria" id="AYE35663">
        <property type="protein sequence ID" value="AYE35663"/>
        <property type="gene ID" value="CP523_15165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61050">
        <property type="protein sequence ID" value="QAS61050"/>
        <property type="gene ID" value="EI377_10120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="247" mass="29715" checksum="523B1C5CF0FFBCF0" modified="2018-12-05" version="1">MEMPSIKVADFEGPFDLLLHLIKKHEMDIYNIEIYKITNQYLRYLDEMKEMDLDITSEFIVVAATLIEIKSKKLLPKVAVQEENEEDIEKNLMIKLIEYKKFKNVSEFFRERYISSGDVYTKMPELIEEKKEQVKTEDLLKNVTLLDLYKLYNDLLETYRLKRNNESVIQKRIFVDKYKLEDKIQYVLEKLQNIKVIEFNEFIAESECKMEAVVTFLALLELIKLRMVRVYQDNSFDNILIKRRHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI20</accession>
    <name>A0A386PI20_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hflX</name>
        <name evidence="7" type="ORF">CP523_14000</name>
        <name evidence="8" type="ORF">EI377_08905</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678635.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00217"/>
    <dbReference type="EnsemblBacteria" id="AYE35450">
        <property type="protein sequence ID" value="AYE35450"/>
        <property type="gene ID" value="CP523_14000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60838">
        <property type="protein sequence ID" value="QAS60838"/>
        <property type="gene ID" value="EI377_08905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="6">
        <location>
            <begin position="364"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="598" mass="67619" checksum="C52107313CC50B93" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI85</accession>
    <name>A0A386PI85_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14365</name>
        <name evidence="4" type="ORF">EI377_09275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676795.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35520">
        <property type="protein sequence ID" value="AYE35520"/>
        <property type="gene ID" value="CP523_14365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60905">
        <property type="protein sequence ID" value="QAS60905"/>
        <property type="gene ID" value="EI377_09275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362726" evidence="2">
        <location>
            <begin position="31"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="183" mass="20654" checksum="6238606CECAAEF3E" modified="2018-12-05" version="1">MKNIKVIVISTIISLVSFGLVSCSTGPINAPEETSKKEESSSDNDIFKKVNEIIDSDKISEKKEELKNENNKNENELNSYKDRYNIDELKNKLDDVKKSVGDFKDSQDKEKIEDEINNITETIESLKETAKKEGAIDSSIKDNIDNLKSSVDDVVSKVKDIDKNKITLDKLQDIKDKLGKLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB0</accession>
    <name>A0A386PIB0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07855</name>
        <name evidence="2" type="ORF">EI377_02545</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675853.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00674"/>
    <dbReference type="EnsemblBacteria" id="AYE34346">
        <property type="protein sequence ID" value="AYE34346"/>
        <property type="gene ID" value="CP523_07855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59742">
        <property type="protein sequence ID" value="QAS59742"/>
        <property type="gene ID" value="EI377_02545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="314" mass="33442" checksum="B2BFB99C7DC3B3D2" modified="2018-12-05" version="1">MEKKYVIGVDLGGTKIYTALVDLDGKIKKEITIKTEADKGEVAVLEKILYTIDHVLVGSDINEVRAIGIGSPGPLDVEKGLIVYTPNLPFKNFNIVKPIREKYNVDTYLDNDANVATLGEFMFGAGKGSKNMVFITASTGIGGGAILNGSLFRGSTSNALEIGHMTVMNGGPRCGCGNTGCAESLASGTAIMKRANEAVESNAYTSLKNYEKITAREVFIEAEKGDREAQDILNNALTYLGITIANAANIFDPDIIVLGGGVSNGGRIVFDKIKEEMDRRCLRTIANHCEVKKAMLDSKAGVLGAAALAILESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB7</accession>
    <name>A0A386PIB7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12100</name>
        <name evidence="3" type="ORF">EI377_06930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673516.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02977"/>
    <dbReference type="EnsemblBacteria" id="AYE35097">
        <property type="protein sequence ID" value="AYE35097"/>
        <property type="gene ID" value="CP523_12100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60490">
        <property type="protein sequence ID" value="QAS60490"/>
        <property type="gene ID" value="EI377_06930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="236" mass="26577" checksum="881A45FED4A997EF" modified="2018-12-05" version="1">MKAIIDLHCHTISSGHAYSTIKENIEGAIENGIKILGVSDHGPEMPGGPYIFHFGNLRVLRENINGVRMLKGVEANIIDYNGNIDIPEDVLEGLDYVIASLHPPCIPFGSIDENTRAVIKAIENKYVKIIAHPDDNRYPLNYEEIVKVAKKNNVLLEVNNSSLKADSYRPGALENYKTMLNLCRENKVKIILGSDAHIWYDVGRFDNCERLIKEVGFPEELVVNYNEKDLKELGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH2</accession>
    <name>A0A386PIH2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674693.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01581"/>
    <dbReference type="EnsemblBacteria" id="AYE34406">
        <property type="protein sequence ID" value="AYE34406"/>
        <property type="gene ID" value="CP523_08190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="332" mass="37094" checksum="2CE354510F794BEB" modified="2018-12-05" version="1">MATSIKDVAREAGVSIATVSRVLNDIDVVNEDTKKKVLDAIKKLGYRPNIVARSLKTQRTKTIGILVPDISSGFYPEIVRGAEDVANIYDYNVILCNSDFDSEKEKEYLRVLKEKMVDGVIYMSSSLHDEILDIINELDLKTVLVETKDKDGTLPSVTIDNIKATYESTNYLFNKGLKNIAFVGARKDSMNAWGDRYIGYENALNDKGLKIDEELVFTETLKVTTGYDAIESFESLNKEYDAVVCASDEIAMGVINGLRDHGKKVPEDVSVIGFNDNAVASVFYPKITTINQPSYDMGSVAMRMLIKLLAKKEVEEAQYVLDYNLVERESCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII9</accession>
    <name>A0A386PII9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_09710</name>
        <name evidence="6" type="ORF">EI377_04510</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676728.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02648"/>
    <dbReference type="EnsemblBacteria" id="AYE34678">
        <property type="protein sequence ID" value="AYE34678"/>
        <property type="gene ID" value="CP523_09710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60079">
        <property type="protein sequence ID" value="QAS60079"/>
        <property type="gene ID" value="EI377_04510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="24794" checksum="38AA20123390CA74" modified="2018-12-05" version="1">MDFIKLVNISKVYENDFTALNNINLTINKGEFIALMGPSGSGKSTLLNIIGCLDSSTTGTYILDGNDCTNKKFNKLCDVRNKKIAFIFQNFALIKELNVIENILLPLEYRNNYDKKEVLEKLEKYLIKLGLDEIKYKKVKKLSGGQQQRVAIARALMQGSDLILADEPTGSLDEENGKIIMKILNSLNEDEKKTIIVVTHNLEVAKYCNKIITLRDGMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM1</accession>
    <name>A0A386PIM1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="9">CMK</shortName>
            <ecNumber evidence="2 9">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ispE</name>
        <name evidence="12" type="ORF">CP523_10060</name>
        <name evidence="13" type="ORF">EI377_04860</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676575.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00341"/>
    <dbReference type="EnsemblBacteria" id="AYE34718">
        <property type="protein sequence ID" value="AYE34718"/>
        <property type="gene ID" value="CP523_10060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60119">
        <property type="protein sequence ID" value="QAS60119"/>
        <property type="gene ID" value="EI377_04860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10060"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="84"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="202"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="280" mass="31154" checksum="064C9DE8D7CA2BB3" modified="2018-12-05" version="1">MKIKAYAKVNISLDVVGKRDDGYHLLRMIMQNIDLYDEIIIEKQKKDITLKCNKPYIPVDDRNLAYKAAKLFKETYGVESGVYINIKKNIPVAAGLAGGSTDAAAVFKAMNDIFEVGASEEELMNLGLKLGADIPYCIKGGTALCEGVGEIVTSLGSFKDKILVLVKPPFGVSTKAVYQEFDLTKAVNHPKTEELIYAMGRDDLNFVSNNMKNLLENVTLRKHKMIIGIKEEMKSQGSIGTMMSGSGPSVFAFFDDMLKAQKCFEKMKEKYEDVYLTRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM3</accession>
    <name>A0A386PIM3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678578.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03130"/>
    <dbReference type="EnsemblBacteria" id="AYE35670">
        <property type="protein sequence ID" value="AYE35670"/>
        <property type="gene ID" value="CP523_15210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="65" mass="7359" checksum="DFD8A64B02D649B5" modified="2018-12-05" version="1">MKILTWNARVRKDLTLVELAKLTGISKSTLNNIENGKVIPKISQLEAIAKATDTRIIELFESEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU3</accession>
    <name>A0A386PIU3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1292 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12135</name>
        <name evidence="3" type="ORF">EI377_06965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673541.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35104">
        <property type="protein sequence ID" value="AYE35104"/>
        <property type="gene ID" value="CP523_12135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60497">
        <property type="protein sequence ID" value="QAS60497"/>
        <property type="gene ID" value="EI377_06965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="78" mass="9130" checksum="9B28E4E81DB9D1D4" modified="2018-12-05" version="1">MEEKIMSFNDENGKKVDYAILDQRLICGKEYVALAPVNDKNHIELFKISFDKEWNESLVEVESENELNMFKQVSGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU7</accession>
    <name>A0A386PIU7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-histidine dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10565</name>
        <name evidence="3" type="ORF">EI377_05345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674182.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01388"/>
    <dbReference type="EnsemblBacteria" id="AYE34808">
        <property type="protein sequence ID" value="AYE34808"/>
        <property type="gene ID" value="CP523_10565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60202">
        <property type="protein sequence ID" value="QAS60202"/>
        <property type="gene ID" value="EI377_05345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="208"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="483" mass="53650" checksum="2E033653148E51FF" modified="2018-12-05" version="1">MNVLQNIEPKAVFKYFEEISKIPRGSGNEKEISDYLVKFAKDLNLEVIQDKALNVIIKKPGTKGYENSNIVIIQGHMDMVCEKNKGTNHDFEKDPLKLRVIDDMIYATDTTLGADNGIAIAYALALLASNDIAHPPIEVLITTDEETGMSGAMAVSKEDVKGKVLINLDNEEEGDLLVSCAGGIRSKFTIDVDFEDIDNSSIIELSVRGLKGGHSGMEINKERGNSNKIMGRILKDMLSEIDFRIISINGGAKDNAIPREMDAIISVKEVDIEKVKALVEKWQKILLNELKAQDSGVKILVNKLDNTTTKVFSKESTNKTVNLLYLIPNGINTRSVEIDGLVESSSNIGVVKTINNKVTFDSAIRSSVSSLKDEIVLRSKTIAELLNVKFETSARYPEWQYNSDSKLRDLCQEVYKKMYGKDANIVAIHAGVECGLFNERLGGLDMISFGPNLYDVHTPEEHMSIESVQNVWEYLKEVLKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY6</accession>
    <name>A0A386PIY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_13695</name>
        <name evidence="11" type="ORF">EI377_08585</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02083"/>
    <dbReference type="EnsemblBacteria" id="AYE35397">
        <property type="protein sequence ID" value="AYE35397"/>
        <property type="gene ID" value="CP523_13695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60786">
        <property type="protein sequence ID" value="QAS60786"/>
        <property type="gene ID" value="EI377_08585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="410" mass="46451" checksum="ED3C72F0582986CC" modified="2018-12-05" version="1">MEMEKMLKKYAELAVKKGVNTQENQTVIINSPIECDNFAREIAKAAYNVGAKEVVVHYNDQKLQRIKLENSSIETLSNTPEWLGESYNYYARNGACVISISASDPDAYKGIPVEKISAMQKSRQLALSEYYEYSMANKIRWTVVSIPTEAWAIKIFPNLSKEKAVEKLWEVIFKVVRLDTENPIKAWEEHNKNLREKLTYLNEKKFKKLHFKNNKGTNLTIELPEGHIWLGGSEYCSNGIEFNANMPTEEVFTLPKKDGVNGTVFSSKPLSYSGNLIDEFSLTFKDGKVIDFSAKEGYEVLKELLDSDEGSKYLGEVALVPYDSPISNSNIIFYNTLFDENAACHLAFGKAYPICIEKGTDMSKEEFENHGVNTSIIHVDFMIGTNDLEITGITEDKDSFEIFANGNWAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY8</accession>
    <name>A0A386PIY8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="8" type="ORF">CP523_09050</name>
        <name evidence="9" type="ORF">EI377_03795</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876954.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00249"/>
    <dbReference type="EnsemblBacteria" id="AYE34556">
        <property type="protein sequence ID" value="AYE34556"/>
        <property type="gene ID" value="CP523_09050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59956">
        <property type="protein sequence ID" value="QAS59956"/>
        <property type="gene ID" value="EI377_03795"/>
    </dbReference>
    <dbReference type="GeneID" id="66300469"/>
    <dbReference type="KEGG" id="csep:CP523_09050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362748" description="50S ribosomal protein L6" evidence="6">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="7">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="7">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="19637" checksum="7EB109F76948AD69" modified="2018-12-05" version="1">MSRVGRLPIAIPAGVTVTVSAENVVTVKGPKGELVKAMNKDMNIAVEDNQVVVTRPSDQKEHRALHGLTRALINNMIIGVEKGFEKSLELIGVGYRAQLQGKKLVMNLGYSHPVEIEPIEGVTFETPAATKVVVKGIDKEKVGAAAADIRSWRKPEPYKGKGIKYDNEVIRRKEGKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB1</accession>
    <name>A0A386PJB1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trk family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_14585</name>
        <name evidence="11" type="ORF">EI377_09555</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678670.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00195"/>
    <dbReference type="EnsemblBacteria" id="AYE35557">
        <property type="protein sequence ID" value="AYE35557"/>
        <property type="gene ID" value="CP523_14585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60944">
        <property type="protein sequence ID" value="QAS60944"/>
        <property type="gene ID" value="EI377_09555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="446" mass="48565" checksum="425F58E8A17FBB63" modified="2018-12-05" version="1">MRFKLKKKIKLNGVQILALGFLSFILLGGIILSLPISSASKESTNFLDALFTSTSAVCVTGLVTLNTSAHWSTFGQTIIMMLIEIGGLGFMSFTTLIAIMIGKKITLRERLVMQEAMNTFNLQGLVSMVRYVFGFTFAVQLFGALLMSTQFIPQYGLKTGIFYSIFHSISAFCNAGFDLFGNSLVGYSSNVVIILVISALIIISGIGFTVWLEIYHYKSGKKLTVHAKIVILMTLVLIFGGTILMFIFEIRNPATLGSMNFKDKVLNAFFASVSPRTAGFNSVPLADMTMAGKFLTILLMFIGGSPGSTAGGLKTSTFGIIILTVISVIKGREDTEVFGRRFSKELVYKAFALLFIGVGLIIVVTMMLSYTEVGATFMDLLYETTSAFGTVGLTTGLTPNLSKIGKVLIMLMMYFGRVGPLTVALALTRRRKKSGYKYPEGKILIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB6</accession>
    <name>A0A386PJB6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5651 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13080</name>
        <name evidence="3" type="ORF">EI377_07950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677839.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35281">
        <property type="protein sequence ID" value="AYE35281"/>
        <property type="gene ID" value="CP523_13080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60675">
        <property type="protein sequence ID" value="QAS60675"/>
        <property type="gene ID" value="EI377_07950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043711">
        <property type="entry name" value="DUF5651"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18892">
        <property type="entry name" value="DUF5651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5651" evidence="1">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="155" mass="18285" checksum="4A6900BF7364F30E" modified="2018-12-05" version="1">MKDYLNNEERKNIITILHLMTSGVILLEGNTLTKDEKANLKRGFTFTKKAIENIKNRLNKNALNALDKDAKKSRVLLDIYGATREYERRKQSDINAAYEENRDYYKLVELILFYNCKNCSEKCNECEIYKEFEERCIPEFEGAEKMGYCKYSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJD3</accession>
    <name>A0A386PJD3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_13465</name>
        <name evidence="9" type="ORF">EI377_08365</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677572.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35354">
        <property type="protein sequence ID" value="AYE35354"/>
        <property type="gene ID" value="CP523_13465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60745">
        <property type="protein sequence ID" value="QAS60745"/>
        <property type="gene ID" value="EI377_08365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="211"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="31813" checksum="81D45610BB971362" modified="2018-12-05" version="1">MNNRLNIGIKVSKTTIIGNILLSIIKILIGFFSKSNAMVADGIHSFSDVISTIGVIIGLKLSNKPADKEHPYGHERIESLVSLLLSIMLFLVALGIGMSGASDILNKTFTIPSMLAIFAALLSILAKEWMYFYTMKYAKLIDSASLKADAWHHRSDSLSSLGALIGIIGARIGFPILDPLASLIICILILKVSYEIAKQSISQLVDESAKDDTITEIISKINSIDDVRKIDSVKTRLHSTKIYVDVEISVDSFLTVEEGHDIAIKVHNLIEENRKIKHCMVHVNPFVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE1</accession>
    <name>A0A386PJE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11785</name>
        <name evidence="3" type="ORF">EI377_06605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02915"/>
    <dbReference type="EnsemblBacteria" id="AYE35038">
        <property type="protein sequence ID" value="AYE35038"/>
        <property type="gene ID" value="CP523_11785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60431">
        <property type="protein sequence ID" value="QAS60431"/>
        <property type="gene ID" value="EI377_06605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="330" mass="37116" checksum="4CE864A319815C2F" modified="2018-12-05" version="1">MAISFKLQHILNSILINSKSIIDAFKKIYPPAYYFSQGVTNLDIKSLSMFIILSIIPFIIFLAIFNKVFKNINSKLGESFKKSNYKLIELKASSPIKALLKKEIKRYFSSSIYVVNTLVGLVLITMFSISCLLFGRDILELILKIQVDKEMIPLALIVFLSGAVSLSCTTQNSISIEGKNLWILKSLPLEVMDIFKEKIGLNLMILIPTIFINAVILIFTFNLSLVNMIWVISIPIIYSILISIIGLIINLYFPKFDWISEVTVVKQSLSSFLGIFIGMILVFIPIGIFIVFNIECINIYLSVVAGCLIGTIVLSLFILNTKGVELFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG6</accession>
    <name>A0A386PJG6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14965</name>
        <name evidence="3" type="ORF">EI377_09920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676056.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35627">
        <property type="protein sequence ID" value="AYE35627"/>
        <property type="gene ID" value="CP523_14965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61014">
        <property type="protein sequence ID" value="QAS61014"/>
        <property type="gene ID" value="EI377_09920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="148" mass="16757" checksum="BF9A94D1FB88D687" modified="2018-12-05" version="1">MKKKPAFMILELMVSMLIIVIIMGCGLKLIKSFQIIKEKEGINNSIYEIIDVFSYAKGYCRKNSEIGYVRINEKNKSIEFTPSIYNTKLKEVYMPKDVILVSNFSGGNRIKVSESGYITSAGKIEIRYKKKVISTITISAGNDIINIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG8</accession>
    <name>A0A386PJG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="10">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagA</name>
        <name evidence="9" type="ORF">CP523_10280</name>
        <name evidence="10" type="ORF">EI377_05060</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01439"/>
    <dbReference type="EnsemblBacteria" id="AYE34756">
        <property type="protein sequence ID" value="AYE34756"/>
        <property type="gene ID" value="CP523_10280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60156">
        <property type="protein sequence ID" value="QAS60156"/>
        <property type="gene ID" value="EI377_05060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="47"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="215"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="378" mass="40575" checksum="99680B538A56C072" modified="2018-12-05" version="1">MLIKNCNIIFLDRIENGSVLIENGKIKEINPTNIKCNEVIDGEGLYLSPGFIDVHIHGAGGYDTMDGTVEAINEISKAIVKHGTTSFTPTTMTVSIDAIRKSMEAIKTCKENGTDGAQVLGAHLEGPFISPNAIGAQNPKYLIAPTIENYNSMVGDAKDAVVSITIAPEVPGATDLIKYLSEQGIVCSMGHTKATYDEAMEGIKCGCCHSTHLFNAMTPFTHREPGVVGAIFDTDITTETISDGIHISFPSLRVAYNQKTTDKVLLVTDAMMACGMPDGMYSLGGQDVVVTNGAARLTSGSLAGSVLTLDKAVRNVFNNTKYPLNEVVKMATFNGARHCKVEDRKGLIKEGYDADVILFDENINIRKVIVNGEVVHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL2</accession>
    <name>A0A386PJL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13965</name>
        <name evidence="3" type="ORF">EI377_08855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00160"/>
    <dbReference type="EnsemblBacteria" id="AYE35444">
        <property type="protein sequence ID" value="AYE35444"/>
        <property type="gene ID" value="CP523_13965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60831">
        <property type="protein sequence ID" value="QAS60831"/>
        <property type="gene ID" value="EI377_08855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="107" mass="11841" checksum="BEF85363E7A0CB1B" modified="2018-12-05" version="1">MIIEINPNTLLLGIITISIVIAIIYLIITLRKVLALLDNLNKTLVDNKSNLDNTFKNLSDITDNVKDISDVAIETTAEALVVKEDLINRLDIIKDIANIIAGVFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJV9</accession>
    <name>A0A386PJV9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_01985</name>
        <name evidence="9" type="ORF">EI377_12505</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678300.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35797">
        <property type="protein sequence ID" value="AYE35797"/>
        <property type="gene ID" value="CP523_01985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62217">
        <property type="protein sequence ID" value="QAS62217"/>
        <property type="gene ID" value="EI377_12505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="356" mass="39816" checksum="308D75EFFF1F3A83" modified="2018-12-05" version="1">MAIIIGIVGYKIIDNYRYFFNILGRLLSLCVPFIYGLVIAYILNPLVKLLERRFKLKKGIAILSTYALIISIFTLIAFYWIPSVVESAIDLTKDIPSYILSMQNWINDVLSNQNIKDIIVSTGTMDTVNGIISQVGAFTVSLLEGSFSYVFSISSNLLKFVLGIMISVYVLVDKERLLKGTKRILFIILKEEKSKKFIEFIRIYHHMIGTYIGIKAIDSSIIGFMAFILLNLVKSEYALLLAFIVGLTNMIPYFGPFIGEAVGFLFNIFVSPTKAFTVFLVLLSLQLFDGWYLDPKLIGGKVGVRPVFIILGVVVGGGFFGPIGMLLASPTVATVKFYINRLMDRNKELVDIADKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJW4</accession>
    <name>A0A386PJW4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678067.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02692"/>
    <dbReference type="EnsemblBacteria" id="AYE34499">
        <property type="protein sequence ID" value="AYE34499"/>
        <property type="gene ID" value="CP523_08755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="109" mass="11821" checksum="E44C8D2445E78B10" modified="2018-12-05" version="1">MKLVIAIVQDDDAIDLVDAITEAGFRVTKLATTGGFLKSGNTTLMIGVEKEKVQKVIEVVEDICRTRKQMIATPAPISGNADMYMSYPIEVQVGGATVFVVDVDQFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKB4</accession>
    <name>A0A386PKB4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35711">
        <property type="protein sequence ID" value="AYE35711"/>
        <property type="gene ID" value="CP523_15425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="357" mass="42027" checksum="C43CD9975D795BAD" modified="2018-12-05" version="1">MNDIKKRLFRELDIRDVFFDSLKKDYPGFIGWFKKKADENESAYILDKNGIQGFLYLKVEDEIYNNIKPTLKKFKRLKVGTFKINAHGTNLGERFIKILIDEIFKEGVSEAYVTIFPKHEALIKLLEKYGFKYFGVKSSDAGEENVYLKSIKEINNDILMDYPRVNYSGVNKFMLSIWPKYHTKMFPDSKLKTEKNHIIEDLSITNSIEKIYLSGADLSNYKKNDIVLIYRTKDKEKSASYSSVATSICVIEEVKHIDDFKDYNEFKRYCIKHSVFSEYELGRFWKSKQYKYLIKMLYNVALPKRIVRQDLINKIGLDKNRWVAVNLTDKQFEKILRLGEVNESIIINQTTICSENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKB5</accession>
    <name>A0A386PKB5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcrA</name>
        <name evidence="9" type="ORF">CP523_09715</name>
        <name evidence="10" type="ORF">EI377_04515</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676733.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02649"/>
    <dbReference type="EnsemblBacteria" id="AYE34679">
        <property type="protein sequence ID" value="AYE34679"/>
        <property type="gene ID" value="CP523_09715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60080">
        <property type="protein sequence ID" value="QAS60080"/>
        <property type="gene ID" value="EI377_04515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="286"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="744" mass="85307" checksum="F614CF12BB88F7F0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE1</accession>
    <name>A0A386PKE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12150</name>
        <name evidence="3" type="ORF">EI377_06975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673550.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02986"/>
    <dbReference type="EnsemblBacteria" id="AYE35106">
        <property type="protein sequence ID" value="AYE35106"/>
        <property type="gene ID" value="CP523_12150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60498">
        <property type="protein sequence ID" value="QAS60498"/>
        <property type="gene ID" value="EI377_06975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="183" mass="21098" checksum="B430D7E340A54841" modified="2018-12-05" version="1">MKKELILKRKDGKIIEVKLREMDSSYIDKILELQDIILNGLENKELYAPTEREEFIEYLNKGGKIIGYFTKDKLLVAMGVYIEKGYDSGNYGYDIGLEGNELLRVGQIESTVVRDEFRGNGIQKIICEAFEEIAKENKMNILCATASPYNKFSVNTFEKLGYKIAKDKIKYDGLRRYVLVKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE9</accession>
    <name>A0A386PKE9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675185.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01968"/>
    <dbReference type="EnsemblBacteria" id="AYE35212">
        <property type="protein sequence ID" value="AYE35212"/>
        <property type="gene ID" value="CP523_12705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="130"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="338" mass="39339" checksum="67474B0863FA7310" modified="2018-12-05" version="1">MKDKKIINILISYYKDKLSIIIKFLVFMGIFFLVYSLYHLPLGVFLYAALIVSTLAFLFSLYDFNIYYNKHNVLISVLNEVEYSLDKLPKSNSLINKDYESIIETLYNHKTNLKTNLDFKYENTVNYYTMWAHQIKTPISAFSMIVQSMDSSVEKNMMKQELFKINEYVDMVLYYVRLENLSYDLKLQEYSLKEIIKGAIKKYSATFVYKKIALDLEDITCNIITDEKWITFVIEQILSNSLKYTNKGTISIYMDKESKNTLVIEDTGIGIVEEDVSQIFEKGFTGYNGRRDKKSTGIGLYLCNEIATRLSHKLYVTSKVGVGTKVYIDFSTNNIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKG4</accession>
    <name>A0A386PKG4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0397 protein CP523_12810</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12810</name>
        <name evidence="7" type="ORF">EI377_07685</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0397 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678195.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02799"/>
    <dbReference type="EnsemblBacteria" id="AYE35232">
        <property type="protein sequence ID" value="AYE35232"/>
        <property type="gene ID" value="CP523_12810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60627">
        <property type="protein sequence ID" value="QAS60627"/>
        <property type="gene ID" value="EI377_07685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01572">
        <property type="entry name" value="UPF0397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022914">
        <property type="entry name" value="UPF0397"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="20134" checksum="E43C22343FE0B344" modified="2018-12-05" version="1">MRYKKLSIKTIVAIGIGSAVFMILGRFGSIPTGIPNTNIETAYAFLALMALLYGPLAGMLIGFIGHALKDIVFYGSPWLSWVLASSAVGLIIGMSWRKIKINEGIFDKKQIIIFNIIQIIANGVAWFFVAPTLDIIIYAEPANKAYLQGLIGGISNMITIGVLGSILISNYAKTRIKRGSLKREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKK5</accession>
    <name>A0A386PKK5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35821">
        <property type="protein sequence ID" value="AYE35821"/>
        <property type="gene ID" value="CP523_04850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025051">
        <property type="entry name" value="DUF3990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13151">
        <property type="entry name" value="DUF3990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="57" mass="6952" checksum="120AC3846B50BBFB" modified="2018-12-05" version="1">MWQDELTQRANANRVSSEFPEIRKHRFTKDFSWGFYCTEIQEQAEKWASKFNTSIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKX6</accession>
    <name>A0A386PKX6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="4">SDH</shortName>
            <ecNumber evidence="1 4">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">aroE</name>
        <name evidence="6" type="ORF">CP523_11400</name>
        <name evidence="7" type="ORF">EI377_06215</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673271.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02837"/>
    <dbReference type="EnsemblBacteria" id="AYE34969">
        <property type="protein sequence ID" value="AYE34969"/>
        <property type="gene ID" value="CP523_11400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60362">
        <property type="protein sequence ID" value="QAS60362"/>
        <property type="gene ID" value="EI377_06215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11400"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>shikimate</name>
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        </ligand>
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        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="30491" checksum="3C2830BD199CD7D9" modified="2018-12-05" version="1">MEFYGLLGEKLSHSLSPKIHKLILDELNLEGAYKLFEVEREDLKDFSKGLKILKIKGVNVTIPYKQDIMEYLDSISKEALRIGAINTIELKESKLYGYNTDYYGFGYMLDAHNIEINEKVAVILGNGGATKAVLHYLLDNKISKVYIVSRNPKINNEFKEERVKLIGYEELDEINGDILINSTPVGMYPKVEASPIDSEIVDKFSILVDLIYNPMETKFLKYGRKLNKKTVGGLYMLVGQAVKAEEIWHGIKIEKEVINKIYNKLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL77</accession>
    <name>A0A386PL77_CLOSE</name>
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        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ORF">CP523_14185</name>
        <name evidence="10" type="ORF">EI377_09090</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="EI377_09090"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="10594" checksum="39DACE3350D35867" modified="2018-12-05" version="1">MLKMNLFITLLPIILMFGLMYLLLILPEKKRNKKYNEMLSQLEKNDEVMTRGGIIGKIIIIEENNVIIETSAERTKIKVSKTGIATKLNKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL88</accession>
    <name>A0A386PL88_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675377.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02048"/>
    <dbReference type="EnsemblBacteria" id="AYE35139">
        <property type="protein sequence ID" value="AYE35139"/>
        <property type="gene ID" value="CP523_12320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="282" mass="32091" checksum="E4DF1002B66D809D" modified="2018-12-05" version="1">MKKDKKILKIYSTLLFAFILLFTSLVYPIKALDNVRISLDSNNKDTLPQNFRKTTDISKASELKSINLTGLDKLNISGSGQFTEFNLPLIVKAIGDNFSIIDIDLREESHGFINGIAISFSNPHNNVNKGLTLNQVIEQENSDLASIKLDTPLTLYNNKLTLTPKVVENEDKLVKSNNLSYLRIPVTDGSLPNDDMVNYFVEFVKNQPKNSWLHFHCKAGIGRTTTFMIMYDIMKNCNEVSLNDIISRQVLLSDISKKNAVDFYAGRRYEFLNKFYNKCKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL97</accession>
    <name>A0A386PL97_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12370</name>
        <name evidence="10" type="ORF">EI377_07255</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675355.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02039"/>
    <dbReference type="EnsemblBacteria" id="AYE35149">
        <property type="protein sequence ID" value="AYE35149"/>
        <property type="gene ID" value="CP523_12370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60552">
        <property type="protein sequence ID" value="QAS60552"/>
        <property type="gene ID" value="EI377_07255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="18"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="51351" checksum="88F1679CC2540F01" modified="2018-12-05" version="1">MEISFNTEKEIEEVKIKKAVPAVLGLMIFALVIDNSFKIISPDLASTFNLSATAVSWQVTLAGLVIGIGAIVYASLSDSISVRNLLAIGILLICIGSLLGFIFQKSFLMIVISRIIQSAGLGSAETLYVIFVAKYFKDNEKKKYLGFSTSSYALSQVIGTITGGYVATYLRWQVLFLVPLLTLLILPFILKYIPKDETKGGNVDFIGFILVSSVAALLMLFVSEFKWMYLVAFLIMLVLFITYISKNKKAFISIKFFTNRNFISILAVAFVIYSVQLAFIFMFPFLIENIYNYRLDQVSLILLPSYILAAIVGATSGKISKKIGNKQCIELAIIGIIISLLLGTFFIETSVYVFIFIMVLFSISFALMYAPMIDTLIKTIPEEKSGTAIGFYNFCLSMAASIGITYVALLMEIKPLGKNITGLFENSLSIQYSNVLLVLAVISAVAFLLYWTLVGRREKIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLJ0</accession>
    <name>A0A386PLJ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">CP523_15060</name>
        <name evidence="10" type="ORF">EI377_10015</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676019.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01272"/>
    <dbReference type="EnsemblBacteria" id="AYE35646">
        <property type="protein sequence ID" value="AYE35646"/>
        <property type="gene ID" value="CP523_15060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61033">
        <property type="protein sequence ID" value="QAS61033"/>
        <property type="gene ID" value="EI377_10015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15060"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="126"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="30906" checksum="11C9F0614CF96FC8" modified="2018-12-05" version="1">MGQIINGKEIALKVKENIKEYINERENKGLKRPKIASILVGNDGGSIYYMNNQEKVANSLNCDFEKIILEDTIAENNLINIIEKLNKDKSIQGIILQLPLPKNFNEKKVIASISPKKDIDCLTYESQGKLYMGEKGFLPCTPNSVVTLLESLNIDLQGLEVVVLGRSNIVGKPVAQLLLNKNTTVTICHSKTKDLKSVCKRADILIVAIGKPKFINKKYIKEGAIVIDVGTSSFEGKITGDVDFEDVIDLASFVTPVPGGVGALTTTLLIKNACEAMENNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLL2</accession>
    <name>A0A386PLL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S cluster assembly scaffold protein NifU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nifU</name>
        <name evidence="2" type="ORF">CP523_01180</name>
        <name evidence="3" type="ORF">EI377_11680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02282"/>
    <dbReference type="EnsemblBacteria" id="AYE35792">
        <property type="protein sequence ID" value="AYE35792"/>
        <property type="gene ID" value="CP523_01180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62211">
        <property type="protein sequence ID" value="QAS62211"/>
        <property type="gene ID" value="EI377_11680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017787">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03419">
        <property type="entry name" value="NifU_clost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="143" mass="15915" checksum="2384FA3A0ADBA264" modified="2018-12-05" version="1">MYSDKVMDHFKNPRNVGEIEDANGVGEVGNAKCGDIMKIYLKVEDNIIKDVKFKTFGCGSAIASSSMATELIKGKTIEEAWELSNKAVAEALDGLPPVKMHCSVLAEEAIHKAINDYRKSHGLDTWDFEEHNDIHDHVHGHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLN8</accession>
    <name>A0A386PLN8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35832">
        <property type="protein sequence ID" value="AYE35832"/>
        <property type="gene ID" value="CP523_05740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029501">
        <property type="entry name" value="EndoU_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14436">
        <property type="entry name" value="EndoU_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EndoU_bacteria" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="133" mass="14643" checksum="B12DB41B6F15A4EB" modified="2018-12-05" version="1">MTHSTKGDFTYNPKTGKVSRMKGGGHGQDNIDFLIENNIEFNIEKTYSNGVRVGNVPKHKTPSKRIGTGQAWFPENWSNDKIKDAGEYVANLPENINAVDGNIIFGEYDGVRVGVIKTDGKIGTIFPDADMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLR9</accession>
    <name>A0A386PLR9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15665</name>
        <name evidence="4" type="ORF">EI377_10380</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678614.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00558"/>
    <dbReference type="EnsemblBacteria" id="AYE35756">
        <property type="protein sequence ID" value="AYE35756"/>
        <property type="gene ID" value="CP523_15665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61095">
        <property type="protein sequence ID" value="QAS61095"/>
        <property type="gene ID" value="EI377_10380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15665"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="173"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="338" mass="37679" checksum="E8611A309B1F7B77" modified="2018-12-05" version="1">MKMIKVQDAVGTMLSHDVTQIIPGEFKGRIFKKGHIIKEEDIEKLLLIGKDHVYVWEPKDGELHENDAAKRLVPLIMGDGITKSEEIKEGKIDFFADKKGLLKIDKESLLKINSLGEIIVSTIHNNTPIKNGEKIAATRVIPLIIDEKKIIEAEKLIKKPIISIKEYKEKNITLITTGNEVFYGRIKDAFLPVIERKLKEYGNSKVKQIILPDDKERIKEGIKEVIKNGADMVICTGGMSVDPDDVTPTAIKECGGELITYGSPVLPGAMFLLAYKDELPILGIPSCAMYCKRTILDLVLPRILADEKLTLEDIVKYGHGGLCLDCKVCTFPHCSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLW2</accession>
    <name>A0A386PLW2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14415</name>
        <name evidence="3" type="ORF">EI377_09380</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676813.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02474"/>
    <dbReference type="EnsemblBacteria" id="AYE35529">
        <property type="protein sequence ID" value="AYE35529"/>
        <property type="gene ID" value="CP523_14415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60915">
        <property type="protein sequence ID" value="QAS60915"/>
        <property type="gene ID" value="EI377_09380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="315" mass="35492" checksum="829FD1515D01D8CD" modified="2018-12-05" version="1">MIKNSPYILVLGASIVDIIGFSRKKYNPKDSIPGNIKISLGGVCRNISENLARVNVNTEFISILGDDEQGRNILTNAKEIGYSMEHSLILKDEYTPTYMAILNESGEMESAIVDMESIEKMDTSFIDSKEEIIMNSEYTILDADNPELMKYILEKFNGKTKFILDPVSASKAAKIKHLIKYFHTIKPNRLETEMLCGFKIEGTEDLHKAGEYFTKLGVENIFISLDEDGIYYKNSKEEGRIASSKVEVKNVTGAGDSFVAGIGYGYMNGISLKETVKYAIAMSVITISHEENINPNMSEEYVKEFIKTIKWREDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM13</accession>
    <name>A0A386PM13_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14920</name>
        <name evidence="3" type="ORF">EI377_09875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01300"/>
    <dbReference type="EnsemblBacteria" id="AYE35619">
        <property type="protein sequence ID" value="AYE35619"/>
        <property type="gene ID" value="CP523_14920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61005">
        <property type="protein sequence ID" value="QAS61005"/>
        <property type="gene ID" value="EI377_09875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040591">
        <property type="entry name" value="YlmH_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17774">
        <property type="entry name" value="YlmH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="256" mass="29492" checksum="DBEB7E937853A695" modified="2018-12-05" version="1">MINKEYILKSFSKEESFDAIKVYEKLKLASEKDFTVFTSSFYPPNIWSFFVENYNSKILKVETSGFFSESERRIISFNNHYDLQYPFIVLEIINKSKFVNLTHRDYLGAILSLGIEREKLGDIKVHENRAFVPVIEEIGNYIYINLSNIGKASVEVKIVDNFEEVPESCFNEEVLIVSSLRIDSFVSKIAKISRGKSLQLIDSGMVFLNYSKVVNKNQEVQTDFRITIRGIGKFIVGDIIGETKSGKQRVIIKKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM71</accession>
    <name>A0A386PM71_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_15570</name>
        <name evidence="10" type="ORF">EI377_10285</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00168"/>
    <dbReference type="EnsemblBacteria" id="AYE35739">
        <property type="protein sequence ID" value="AYE35739"/>
        <property type="gene ID" value="CP523_15570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61078">
        <property type="protein sequence ID" value="QAS61078"/>
        <property type="gene ID" value="EI377_10285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="3"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="315"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="864" mass="101734" checksum="8E0BFBDD4A4F9948" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAK4</accession>
    <name>A0A386PAK4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore coat</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CotF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00292"/>
    <dbReference type="EnsemblBacteria" id="AYE32963">
        <property type="protein sequence ID" value="AYE32963"/>
        <property type="gene ID" value="CP523_00105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012851">
        <property type="entry name" value="Spore_coat_CotF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39183">
        <property type="entry name" value="PTHR39183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07875">
        <property type="entry name" value="Coat_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="100" mass="11088" checksum="C50A3AD3E60BB272" modified="2018-12-05" version="1">MKNMIGNMIKNNIDINDEFIALSMLSSGKEASDMYLNSTLTSSTPELRAIYSASLGQMVEGHTALTELSVTKGWIKPYNTPDEQLTCSYNESKTCINENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAY7</accession>
    <name>A0A386PAY7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-sensing transcriptional pleiotropic repressor CodY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">codY</name>
        <name evidence="10" type="ORF">CP523_00750</name>
        <name evidence="11" type="ORF">EI377_11245</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CodY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674637.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02370"/>
    <dbReference type="EnsemblBacteria" id="AYE33083">
        <property type="protein sequence ID" value="AYE33083"/>
        <property type="gene ID" value="CP523_00750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61252">
        <property type="protein sequence ID" value="QAS61252"/>
        <property type="gene ID" value="EI377_11245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00621">
        <property type="entry name" value="HTH_type_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014154">
        <property type="entry name" value="CodY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010312">
        <property type="entry name" value="GTP_sensing_CodY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013198">
        <property type="entry name" value="GTP_sensing_HTH_CodY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40062">
        <property type="entry name" value="PTHR40062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06018">
        <property type="entry name" value="CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08222">
        <property type="entry name" value="HTH_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011572">
        <property type="entry name" value="GTP_sensing_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02787">
        <property type="entry name" value="codY_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CodY" evidence="8">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_CodY" evidence="9">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="28734" checksum="A99A99717BA8CB00" modified="2018-12-05" version="1">MSSLLNKTRMLNKILQKSGTDPVAFEDICSLLSEVLACNVYVASRKGKILGHTFSKNFECDIMRKHVIDDKRFPQEYNEKLLNIQDTISNLGNKGLCVFEGEGSCIMEDKITTIVPIIGNRERLGTLILARFGEEFTDEDLVLIEYSATIVGMEVLRAKQDELEEEARKKAVVQLAIGTLSYSELEAVEHIFGELEGTEGLLVASKIADKVGITRSVIVNALRKFESAGVIESRSLGMKGTHIKILNEKLLDELKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBA2</accession>
    <name>A0A386PBA2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01380</name>
        <name evidence="3" type="ORF">EI377_11895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675583.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33203">
        <property type="protein sequence ID" value="AYE33203"/>
        <property type="gene ID" value="CP523_01380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61375">
        <property type="protein sequence ID" value="QAS61375"/>
        <property type="gene ID" value="EI377_11895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="456" mass="50253" checksum="0339E880E2E5EFE5" modified="2018-12-05" version="1">MQITRDKRFYRLLLSISLPIAMQNLITFAVSMIDTLMVGSLGEVQLSAVSIANNLFFVLMILMFGLAGGSNIMISQYWGKGDKKAIHKILAIMYRVCITITIVFIFIAIFIPSKFMGIFTTDLAVIEAGSSYLRIVCIGYIFYAITNCTIMILRSVKTVKISIIVYSISLIVNAFFNWVLIFGNLGAPQLGIKGAAIATVIARICEFLIVLVFMSVFENKILLKLKHFKKVDKIILNDYISICTPVLCNELFWSIGASMISVVVGRMGTDVVAANSINGVAHQFVTVFIFGLSNASSVIIGNTIGEGKREKAKEYAFTIGIFSVVMGIIASGIIYIIRPIVVDFYNVTLFTKGIAMDIMKVTSIIVIFQSLGVNLMMGVLRGGGDAKFVLINDIVFMWLVAIPGGFIGAFLLDLPVALVFFIIKSDEILKSIVSVFRVLSGKWVRDVTRDFVEIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBR9</accession>
    <name>A0A386PBR9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00235</name>
        <name evidence="3" type="ORF">EI377_10650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677377.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01185"/>
    <dbReference type="EnsemblBacteria" id="AYE32987">
        <property type="protein sequence ID" value="AYE32987"/>
        <property type="gene ID" value="CP523_00235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61145">
        <property type="protein sequence ID" value="QAS61145"/>
        <property type="gene ID" value="EI377_10650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019365">
        <property type="term" value="P:pyridine nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044717">
        <property type="entry name" value="NIC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47297">
        <property type="entry name" value="PTHR47297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="24061" checksum="282F70AC00845748" modified="2018-12-05" version="1">MFQTIERIQEEINSIKKITLDEIKGKKALIIVDMVKGFYNIGPLASSRVSKVINPISILANKFENDEKIFFIDSHTKNSVEFKSYPIHCVKESVEEELIDEIKVISKLTKSKIIKKNSINGFHSIEFKNWLENNMDIDTFVITGVCTDICVETFALTLSTYFHELNVEKNIIVPMNMVETYDFGNHNGDLMNLITFFKLKSNGIKVVKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCQ0</accession>
    <name>A0A386PCQ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03290</name>
        <name evidence="3" type="ORF">EI377_13805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677226.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02126"/>
    <dbReference type="EnsemblBacteria" id="AYE33560">
        <property type="protein sequence ID" value="AYE33560"/>
        <property type="gene ID" value="CP523_03290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61723">
        <property type="protein sequence ID" value="QAS61723"/>
        <property type="gene ID" value="EI377_13805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="240"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="303" mass="35549" checksum="7008AA9F59AAC967" modified="2018-12-05" version="1">MDNLKNLLKELCDKTNIKYRLTNDKGEEIFNNLNLDLDIIIKNININNGIYKIYIKRENEILIPFIEFSLDKFIEKNNSIQLLLEGEKPWDSFKETLLFRKGKLFIIDCNNKGEALKVIKNSYCQEDVFIEEVYEQIILVGDLEEEIEHGLSLRESIIQNTGEKVFISVSNLDGTHKGFLKGYRKATEAIKTGKALKIVPEVYISKDMEIENTIYNLKNQYSKSLKSEYDNICKSLNHELILTIEEILRCNFSLTQAAKNLYIHRNTLIYRIEKIKKETSYDIRNFKEATFLYILYVNSKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCU2</accession>
    <name>A0A386PCU2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgeF</name>
        <name evidence="10" type="ORF">CP523_01065</name>
        <name evidence="11" type="ORF">EI377_11560</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674476.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02306"/>
    <dbReference type="EnsemblBacteria" id="AYE33144">
        <property type="protein sequence ID" value="AYE33144"/>
        <property type="gene ID" value="CP523_01065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61314">
        <property type="protein sequence ID" value="QAS61314"/>
        <property type="gene ID" value="EI377_11560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="27771" checksum="945C42D632E2BECA" modified="2018-12-05" version="1">MKKLTIDDLVRHKDFFKLDLGNISIGFSTAENNRSFNRHTEDGIANLESIKNEFGLKNIEYLNQIHSDKSYIYNLGKSVKDKEGDAVITNEKSTAIGVFTADCTPIILVNEEKEVIAAIHSGWRGTFHSIVTKTLDNMIKEYGINIKSTKVFIGPHIRQCCYEISEELKRDFISHTGINENKLFNGRNLSMEAVIVNNLKEKGVEEDNIYSLDICTHCSKDIKMHSYRSSVGTYGRLFSFVYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD04</accession>
    <name>A0A386PD04_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33865">
        <property type="protein sequence ID" value="AYE33865"/>
        <property type="gene ID" value="CP523_04935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017256455" evidence="1">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="179" mass="20153" checksum="2D57801E01989C57" modified="2018-12-05" version="1">MIKIKVKKIICTALASGVLMGVTPALNIAATTNEVIESSNLTEDQREELNYAIEEMRIAIDLVDNADFTDGISYERMVIFATASLDRVRGLEINNEHVEWIEESGDEVRDLTYRINRVLNAIKNVEIVFSKERQDTIENKENVINTLNLVLTQEMEAGALNDATLRSAINILHSYANRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD27</accession>
    <name>A0A386PD27_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_05085</name>
        <name evidence="10" type="ORF">EI377_15645</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676197.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01807"/>
    <dbReference type="EnsemblBacteria" id="AYE33893">
        <property type="protein sequence ID" value="AYE33893"/>
        <property type="gene ID" value="CP523_05085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62044">
        <property type="protein sequence ID" value="QAS62044"/>
        <property type="gene ID" value="EI377_15645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="25394" checksum="FADCFD3A99B37B8F" modified="2018-12-05" version="1">MEKIENDNAELVIQDTIEKRHLYTIIKRIIDILASIIGLVLLSPFLLIIAILIRLESEGPVIFSQKRIGLKGKTFNMYKFRSMVVNAEELKNNLEKENEMSGPMFKIKNDPRVTKVGKFIRKTSIDEIPQLINVLKGEMSLVGPRPSLPKEVKEFEPWMMKRLEVKPGLTCYWQVSGRNNIGFEDWMKLDIKYVKERSVLLDIKLILKTVTVLFGDENAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDG5</accession>
    <name>A0A386PDG5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphocarrier protein HPr</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00585</name>
        <name evidence="8" type="ORF">EI377_11075</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676347.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00648"/>
    <dbReference type="EnsemblBacteria" id="AYE33051">
        <property type="protein sequence ID" value="AYE33051"/>
        <property type="gene ID" value="CP523_00585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61220">
        <property type="protein sequence ID" value="QAS61220"/>
        <property type="gene ID" value="EI377_11075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="86" mass="8837" checksum="600DEF2CFA4CAFB9" modified="2018-12-05" version="1">MVSKEVVVNNGTGLHARPATLLVKKASAFKSDVSIEFNGKKANVKSLIGVLSLGVTKGSAITVSANGDDEALAVEEIANLIATLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDS7</accession>
    <name>A0A386PDS7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00295</name>
        <name evidence="3" type="ORF">EI377_10590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677356.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32998">
        <property type="protein sequence ID" value="AYE32998"/>
        <property type="gene ID" value="CP523_00295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61135">
        <property type="protein sequence ID" value="QAS61135"/>
        <property type="gene ID" value="EI377_10590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788349" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="141" mass="16125" checksum="FA23256CB1D74300" modified="2018-12-05" version="1">MKKRLLTSLVLTTMVIGSASSRNVMAVECKPNSLRVSCEISAPKTAANFDEFWTPENEGFLTSDGKEKIHSFRERVEKGERLSEHEKHEIKELKAEVIKTKLGEQKFNELQKLIEKREGSTDLTLEERARLYELDKEATGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDT9</accession>
    <name>A0A386PDT9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="ORF">CP523_01265</name>
        <name evidence="12" type="ORF">EI377_11765</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674347.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02265"/>
    <dbReference type="EnsemblBacteria" id="AYE33181">
        <property type="protein sequence ID" value="AYE33181"/>
        <property type="gene ID" value="CP523_01265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61351">
        <property type="protein sequence ID" value="QAS61351"/>
        <property type="gene ID" value="EI377_11765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01265"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="234"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="325" mass="35531" checksum="465C5325CB3E7248" modified="2018-12-05" version="1">MNEIVISGIGAYVPSNIVTNDDLSKIVETSDEWIFGRTGIKERRISKEEDTSEIAIKAANAALKSSGIKPDEIDILIVATITPDMFTPSVACMVQKGIGAVNATAFDINAACSGFIYSMQVAEGMLKSFNYKNALIIGAEVLSKIIDWTDRSTCVLFGDGAGAVTLSKSNSIGIIKTFTKSKGEKWESLTAAARDVENPYIQNVQKKQKFINMNGRDIFKFATSIIQESVNKVLDETGYSLDDIKYIVPHQANVRIIDYASKKLGVEENRFYVNLHRIGNTSSASIPIALNEMYEKGLLENGDKIILVGFGGGLTYGSVLIEWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDW9</accession>
    <name>A0A386PDW9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01420</name>
        <name evidence="3" type="ORF">EI377_11940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675599.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00835"/>
    <dbReference type="EnsemblBacteria" id="AYE33211">
        <property type="protein sequence ID" value="AYE33211"/>
        <property type="gene ID" value="CP523_01420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61383">
        <property type="protein sequence ID" value="QAS61383"/>
        <property type="gene ID" value="EI377_11940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="110" mass="12853" checksum="94FFDE99A6917917" modified="2018-12-05" version="1">MADKSQFLRGTLEGCILKIIADRETYGYEIAERLKEYGFSEISEGTIYPILLRLEKNNFITSIKRASAYGPKRKYYNLTNEGKIELKEFYEIWCSIRENIDNIFSNYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE75</accession>
    <name>A0A386PE75_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH/GDSL hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06305</name>
        <name evidence="3" type="ORF">EI377_00780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02420"/>
    <dbReference type="EnsemblBacteria" id="AYE34110">
        <property type="protein sequence ID" value="AYE34110"/>
        <property type="gene ID" value="CP523_06305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59476">
        <property type="protein sequence ID" value="QAS59476"/>
        <property type="gene ID" value="EI377_00780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="187" mass="21915" checksum="FA96500F5BC2A419" modified="2018-12-05" version="1">MIRKLNRNGIKIIYTMIFLISIFLIIKGYISYKNIAREENLKQIEEVVKFIKELESKDVIEVENKINSIDEIKDVKDKDFKKVFENYVIMGDLRAEVLVEYGILNKSSVIAYKGRNTDIAINDIDILENLHPRKIFMTYGMNDMEYFGGNVYSFIQNYEKLIENLKVKSPKSKIYVSDILPVQQKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE83</accession>
    <name>A0A386PE83_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00170</name>
        <name evidence="3" type="ORF">EI377_10725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677395.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32976">
        <property type="protein sequence ID" value="AYE32976"/>
        <property type="gene ID" value="CP523_00170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61156">
        <property type="protein sequence ID" value="QAS61156"/>
        <property type="gene ID" value="EI377_10725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021683">
        <property type="entry name" value="DUF3267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11667">
        <property type="entry name" value="DUF3267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="22716" checksum="5A0A868AA08CBB08" modified="2018-12-05" version="1">MKFLKEISSIPTNDEDLLESVNNLTTYKFNFINLLIKISISIIYAFGLGYSLFYCNGKIISTFIRFLMLFLLTYYLIKVLHEFIHALTLPKIFSNNVNLLFNFKTLSVNVYSNSSVSKYRIIFFLLIPIIILTFIPTILSYLLGFNIYLYVLASVNAILSSKDILNLILVIKNINNDYNILIKPNKLYYNKNTGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE86</accession>
    <name>A0A386PE86_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04400</name>
        <name evidence="4" type="ORF">EI377_14945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00398"/>
    <dbReference type="EnsemblBacteria" id="AYE33767">
        <property type="protein sequence ID" value="AYE33767"/>
        <property type="gene ID" value="CP523_04400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61925">
        <property type="protein sequence ID" value="QAS61925"/>
        <property type="gene ID" value="EI377_14945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362700" evidence="2">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="23973" checksum="C899886FCD6C53B0" modified="2018-12-05" version="1">MRNKMKKISKVFIITLLTFSMITIKGFAIDNKVSNVELVGNANGLVFIPGNEPFLYSDNIVPGDKIKRTIVIKNNHEDSYELFMKAERGIPKEEFDLLNKLNLKVTYKDEVIYEGPASGEDSLSNNISLGVFNSGDKEDLVAEVEFDGPSIGNEFKDKSAEVNWIFTAVKEVKEEIENKPNLGIGSPNTGDKGISLYVVLFLTSMLALIKFNKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED1</accession>
    <name>A0A386PED1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Quinolinate synthase</fullName>
            <ecNumber evidence="3">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nadA</name>
        <name evidence="10" type="ORF">CP523_02390</name>
        <name evidence="11" type="ORF">EI377_12910</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673973.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00489"/>
    <dbReference type="EnsemblBacteria" id="AYE33391">
        <property type="protein sequence ID" value="AYE33391"/>
        <property type="gene ID" value="CP523_02390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61563">
        <property type="protein sequence ID" value="QAS61563"/>
        <property type="gene ID" value="EI377_12910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02390"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="302" mass="34364" checksum="BB16AA677B5DF064" modified="2018-12-05" version="1">MDLKKEILKLKKEKNALILAHFYQSDEIQEIADIVGDSYFLSKKALESNADLIVFCGVKFMAESSKILSPNKKILIPNNDATCPMADIGLLNKLNELKLKNPNAKVVTYINSNIDIKANSDVCVTSSSAKDILDNISEKDTIFIPDRNLGSYLQEKCPNKNFILYQGFCPTHERIDVDEVLELKSKYPKFEVLSHPECRKKVRAQSYFIGSTSEIINYSVTSNSDGFIVLTEEGVLYQMKLNSPNKIFISPENKIICPNMKMITLQDLYNCILKEEFEINLNEYTRLKALKSLKNMHILSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED2</accession>
    <name>A0A386PED2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08115</name>
        <name evidence="3" type="ORF">EI377_02870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675971.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00737"/>
    <dbReference type="EnsemblBacteria" id="AYE34393">
        <property type="protein sequence ID" value="AYE34393"/>
        <property type="gene ID" value="CP523_08115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59798">
        <property type="protein sequence ID" value="QAS59798"/>
        <property type="gene ID" value="EI377_02870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="25669" checksum="148622E9CEE1550B" modified="2018-12-05" version="1">MSRVGEKIKEARLKSGMTQKVLAKKLGVAEKYLNEVEMGRKVAQESFINRAAKILKTDLNDISMVVTDEALMEERKTLSNTPVKPIKNRVEQDEVWTNAFSTVLKNVPIFDYSLNNPKGFRELPIHSNKVEGYHQDKVIYIEVQDDEMTGFRMLKGDLVFSHLVKEITNNGIFLVNYKGQTKIRQIKSIGNSKVLLVSNGGSLLTETMDIKEIQVIAKLERIEITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI6</accession>
    <name>A0A386PEI6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08440</name>
        <name evidence="3" type="ORF">EI377_03185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674810.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34455">
        <property type="protein sequence ID" value="AYE34455"/>
        <property type="gene ID" value="CP523_08440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59858">
        <property type="protein sequence ID" value="QAS59858"/>
        <property type="gene ID" value="EI377_03185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="270" mass="31155" checksum="4EB8BD8C77EE719C" modified="2018-12-05" version="1">MIKRIVSINFKVNNEALRILILFVVGILITNLHYGLMGIDNNTLLMGDVIIETYGGLVTEYSIYNIFYFILWITPYIIVLNLLNLSTIDRFRESTTLVLPRVKKKSKWFIAFNLTIIIRISIYFFTLFLSSLVVVLIKSGYVAFQNSPVHINSVININQYGISLYIILLNILTVVAIQLFLNNLYSIFSRSNEASVIGILFYIAPIFYPKKTEFCKMFLVNNGMLKRYEMFENGFNGLNFKSSLIFIIAFIIINFLIGLFIIKKQDIVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEL2</accession>
    <name>A0A386PEL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33887">
        <property type="protein sequence ID" value="AYE33887"/>
        <property type="gene ID" value="CP523_05055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="311" mass="37894" checksum="BCF946C4D3601E67" modified="2018-12-05" version="1">MKNKVAIIVAYFGKLPNWFQLWLNSCRFNRNFTWIIFTDDSTKYEYPENVIRELISFESIRELISLNLDLDINIQDPYKICDFKVAYGYIFRDYLKEYTHWGCCDIDMIFGDLSKFINDEILDKNDRVLNKGHLMIFKNTEFVNKAYELPYSGENYKYILKSKYHYGFDESAGLDKIYNENKLSQYIPKDTIIADIDFSKYRFTVRNVENYDNQYLYWDNGKVYRKYIKDSKEYEDEFAYIHFQKRRLQIEIKDNSKYLFYPNAIRSISDDLNLYELNRSGFLSEFKTKIRYAKIIFNQKRYRLIHWKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP6</accession>
    <name>A0A386PEP6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34280">
        <property type="protein sequence ID" value="AYE34280"/>
        <property type="gene ID" value="CP523_07360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="170" mass="19248" checksum="D03BB60F96E4EBA0" modified="2018-12-05" version="1">MLSEEEVYNGAKRILKNNNYTLLAGQPPRGVDHLPVVEIKSGTNKEKGSKDSFKPDLIAYKDNMLLIIECKPNFSNSDLQKLHEVLNSQSRLLAFYNELSERGLLNKINKDIKFDEFKKIVFGSLAYSSSPLSNNTILESSNSYSTNETDNKIYHIIVNSWLGDGYIIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU3</accession>
    <name>A0A386PEU3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_00315</name>
        <name evidence="5" type="ORF">EI377_10800</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678124.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00573"/>
    <dbReference type="EnsemblBacteria" id="AYE33002">
        <property type="protein sequence ID" value="AYE33002"/>
        <property type="gene ID" value="CP523_00315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61170">
        <property type="protein sequence ID" value="QAS61170"/>
        <property type="gene ID" value="EI377_10800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="389" mass="43780" checksum="7B3447A5D9FAC562" modified="2018-12-05" version="1">MILQDMILDNVRNMPPSGIRKYFDMVNEMENVISLGVGEPDFVTPWNVREAGIYSLEKGHTHYSSNAGFIELREEISKYLYRRFNTLYDPKEEILVTVGGSEGIDLALRALVGPGDEVIIPEPSFVAYKGCTAFTGATSKIINLKAEDDFKLTPKVLEEAINEKTKVVIIPFPNNPTGAIMTREELASIVEVLKDKNIIIISDEIYAELSYDKEHVSIASFEEVKYKTLVINGFSKAYAMTGWRLGYICGNKILIDAMKKIHQYAIMCSPTTAQYGAIEALKNGDDSVKEMAREYNRRRRVLVNGFRKMGLDCFEPLGALYVFPCIKSTGMTSDEFCEKLLMEERVLTVPGNAFGECGEGFIRACYAASMDDLIEAVKRIERFIKNHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU6</accession>
    <name>A0A386PEU6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">CP523_09145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00267"/>
    <dbReference type="EnsemblBacteria" id="AYE34575">
        <property type="protein sequence ID" value="AYE34575"/>
        <property type="gene ID" value="CP523_09145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="246" mass="27811" checksum="B062560312F754DE" modified="2018-12-05" version="1">MRNIKLIIEYDGTNYLGWQKQNNGITIQETIEEALKDITKEKINLIGSSRTDSGVHAKGFVANFKTNSRIPSERFREALNVKLPNDIVILESSEVEDDFHSRYNAKGKTYSYTILNRDVPIAIGKDYSYQVKGKLDIEEMKKACSYFIGTHDFVAFKSSGSSVKTTVRTITDLHIENYDSYIKIFVTGDGFLYNMVRIIVGTLLVVGRGKIRSSDIKSIIENKARDKAGICVPSRGLVLEKVFYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU9</accession>
    <name>A0A386PEU9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">CP523_09085</name>
        <name evidence="6" type="ORF">EI377_03830</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678378.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00256"/>
    <dbReference type="EnsemblBacteria" id="AYE34563">
        <property type="protein sequence ID" value="AYE34563"/>
        <property type="gene ID" value="CP523_09085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59963">
        <property type="protein sequence ID" value="QAS59963"/>
        <property type="gene ID" value="EI377_03830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="27114" checksum="6CAA588B0C708F7F" modified="2018-12-05" version="1">MIIIKNHNEIDLMRAAGKIVAETLLLVEEKVRPGITTAELDKIAEEFITKHGAKPSFKGLYGFPASLCISVNEQVVHGIPGGYVLKDGDIISVDCGAELNGFHGDAARTFAVGNVSEEAKKLIKVTEESFFKGIEHAKVNNRLTDISHEIQNYVESNGFSVVRDFVGHGIGRVVHEDPEVPNFGRPGRGPKLVAGMTLAIEPMVNIGTYKVKTLKDDWTVVTSDKSLSAHYENTVVILPDGPEILTLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY1</accession>
    <name>A0A386PEY1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin cobaltochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01495</name>
        <name evidence="4" type="ORF">EI377_12015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00851"/>
    <dbReference type="EnsemblBacteria" id="AYE33226">
        <property type="protein sequence ID" value="AYE33226"/>
        <property type="gene ID" value="CP523_01495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61398">
        <property type="protein sequence ID" value="QAS61398"/>
        <property type="gene ID" value="EI377_12015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033579">
        <property type="entry name" value="Anaer_Co_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="283" mass="32636" checksum="5F791C5BA6458F83" modified="2018-12-05" version="1">MKKAILVVSFGTSYLDVLKKSIEKAENQIAEQFKEYKVFRAFTAHIIIKKLKEKNGIFIDTPEEALDKLYKDGFEEVIMQPLHIIPGEEFQYIKNVQKMYQDKFKSLRLGRPIFYYQGIEDLPQDYSIFIETIEDLLKDKEGVVMMGHGTAHFSNAVYGCLQAVLQDHGYENVFVGTVEGYPTFDVVLKRIKRKNIKEVTLLPLMVVAGDHAINDMASDEKDSWKSMLEAEGIKVNIYMHGLGEIDAFNQLYINRIEDIIENRYIDAGETKKGRKNENNNNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ5</accession>
    <name>A0A386PEZ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03525</name>
        <name evidence="3" type="ORF">EI377_14050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677925.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33601">
        <property type="protein sequence ID" value="AYE33601"/>
        <property type="gene ID" value="CP523_03525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61765">
        <property type="protein sequence ID" value="QAS61765"/>
        <property type="gene ID" value="EI377_14050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="16242" checksum="4341A1D71C3453BF" modified="2018-12-05" version="1">MSCNILGKYISNINRDFIKYCEPKLAKYNLTLTTWRCMIVIDKTQNCSLKTIAESLNVDNALITRNIKKLKELNYILKNPRKEDSRYFQLELTSKGKEVLSKVDKFQGLWYEKITTGFNEEEIETLVKLFDKLCMNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF14</accession>
    <name>A0A386PF14_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I-B CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cas5b</name>
        <name evidence="2" type="ORF">CP523_01660</name>
        <name evidence="3" type="ORF">EI377_12180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675696.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00884"/>
    <dbReference type="EnsemblBacteria" id="AYE33256">
        <property type="protein sequence ID" value="AYE33256"/>
        <property type="gene ID" value="CP523_01660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61427">
        <property type="protein sequence ID" value="QAS61427"/>
        <property type="gene ID" value="EI377_12180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013337">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_Tneap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01895">
        <property type="entry name" value="cas_Cas5t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="28158" checksum="BED3EE2FEE69C3FB" modified="2018-12-05" version="1">MKRAVRLEIYQNLVNYKKPTSFQLKETYPLPPPSTVIGMVHFACDYKSYIPMNIGIQGEYNSKINDLYTRYEFAGASYEADRHNVKIDSKEQGKSYGMMRGISTAELLVDCNLVLYIQPEDDSKVEEIFEAFKNPREYISLGRREDLVQINKVEIVELKEVELEENMPLEMDSYIPVSLKNDIKSNATLYTLNKDYTLRTIKKGVETRSWNKIKVIHAVKGSTVIDEYTSLNKDLVNNSVVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF46</accession>
    <name>A0A386PF46_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAK2 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00900</name>
        <name evidence="3" type="ORF">EI377_11395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
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                <person name="Leendertz F.H."/>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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            <strain evidence="3 5">VAT12</strain>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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    </evidence>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">DSM 7534</strain>
        </source>
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    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
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            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02712"/>
    <dbReference type="EnsemblBacteria" id="AYE34520">
        <property type="protein sequence ID" value="AYE34520"/>
        <property type="gene ID" value="CP523_08860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59922">
        <property type="protein sequence ID" value="QAS59922"/>
        <property type="gene ID" value="EI377_03615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="353"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS59922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="466" mass="53541" checksum="C63CD50572C5AE6F" modified="2018-12-05" version="1">MKIFNSLTRKKEEFVPITPGKIKMYVCGPTVYNYFHIGNGRTFIIFDTIRRYFEYRGYEVTFIQNFTDIDDKMIKKANEESTTVKEIGDKYICEYYKDADGLNIKRASVNPRATEYITDIIEFVKGLIEKGYAYEVDGDVYFRTKKFEGYGKLIGQNLEDLQAGARINIDERKEDPMDFAIWKSQKPGEPAWKSPWGMGRPGWHIECSCMAKKLLGDTIDIHAGGMDLAFPHHENEIAQSEALTGKPFANYWVHGAFLNVNNQKMSKSLNNFLTARDALKDYEADVVRFLMLSGHYRVQLNFSKELLDSAKASVERLYNAIANLENLITEVAKENMDDKEKEYLVSLGKYRQKYIEKMDDDFNTADAITAIFDLIKDINSNITIESSKELCEKALAMIRELGGPLGILQKSTKGSLEDEIEELIAKRQEARKNRDFALADKIRDDLKARDIILEDTPQGVRWKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF3</accession>
    <name>A0A386PFF3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02430</name>
        <name evidence="2" type="ORF">EI377_12955</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673967.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33396">
        <property type="protein sequence ID" value="AYE33396"/>
        <property type="gene ID" value="CP523_02430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61570">
        <property type="protein sequence ID" value="QAS61570"/>
        <property type="gene ID" value="EI377_12955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024307">
        <property type="entry name" value="YmaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12788">
        <property type="entry name" value="YmaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="113" mass="12598" checksum="DA83DBB131F620C6" modified="2018-12-05" version="1">MLCSESTQTHVHEFVGSVKLAEFGEDVHNHRFAGVSGEVIPAKCGHRHRICTKTDFFNNHFHKINIITGPPIPVGNGRHVHFVYACTEMSDGHKHQFIVATLIENPIGNSVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF4</accession>
    <name>A0A386PFF4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_10435</name>
        <name evidence="9" type="ORF">EI377_05210</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674230.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01413"/>
    <dbReference type="EnsemblBacteria" id="AYE34785">
        <property type="protein sequence ID" value="AYE34785"/>
        <property type="gene ID" value="CP523_10435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60180">
        <property type="protein sequence ID" value="QAS60180"/>
        <property type="gene ID" value="EI377_05210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
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        <location>
            <begin position="7"/>
            <end position="29"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="794"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="855"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1080" mass="123699" checksum="6957D85F53A2F479" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI3</accession>
    <name>A0A386PFI3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2019 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05750</name>
        <name evidence="3" type="ORF">EI377_00215</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34004">
        <property type="protein sequence ID" value="AYE34004"/>
        <property type="gene ID" value="CP523_05750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59373">
        <property type="protein sequence ID" value="QAS59373"/>
        <property type="gene ID" value="EI377_00215"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018568">
        <property type="entry name" value="DUF2019"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2019" evidence="1">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="115" mass="13369" checksum="B1C89E8E8FF382FF" modified="2018-12-05" version="1">MEQVQRLIEEFITACMRLQESEEAGDYKTTNLQYDKLKKIRANLRTIGKHAFEEIIPLISNENIYVRYNAAFSIIPIEPEKARNTLNEIANSRGIIAFTSKMTLQEWDNGNLKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ5</accession>
    <name>A0A386PFJ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA adenine methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675397.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01470"/>
    <dbReference type="EnsemblBacteria" id="AYE33648">
        <property type="protein sequence ID" value="AYE33648"/>
        <property type="gene ID" value="CP523_03775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    </feature>
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        <location>
            <position position="179"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000398-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="263" mass="30369" checksum="63AB24A759ED7266" modified="2018-12-05" version="1">MRSPIKWVGGKSKSLKYLLPLIPPHEGYVEVFGGAGWLLFAKSPSNWEVINDLDENLSNFWMVLKEKENEFIDSFKYEVISRSIFNNYKEIYKNKTYLDNVNKAHILYYLLKAGIGASLPDGGGCGFGKSKGVSRLRLDKLPNDIVQAHNRLLKVTIECQDFRNIMSYYDTENTFFYLDPPYRDTSRSSYPVGKFTDKDYSDLSNLCKNIKGKFLLSINDDYFIKCLFSNFNITHINIPYSGSNQKKGRENYPELIITNYTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ7</accession>
    <name>A0A386PFJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04535</name>
        <name evidence="3" type="ORF">EI377_15095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33791">
        <property type="protein sequence ID" value="AYE33791"/>
        <property type="gene ID" value="CP523_04535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61949">
        <property type="protein sequence ID" value="QAS61949"/>
        <property type="gene ID" value="EI377_15095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="407" mass="46994" checksum="8651B29F62523D91" modified="2018-12-05" version="1">MGKYLFFNRKKGFFTNILIVIQVILWIYYSSTLAALIQFNSNFINYYKNNFPMEKGAFLTFPKSQLYGTKLDFEELIKSFEENNIKYGICFNKLNKIEEEAIPEEVLGVKAKEIAVKMSEKYNGEGYIENIKVNKGCIEYYKNKIISDDNIEDIWEIDEENKICPIVIGNNLSCSLKINDEFEYNGMKFIVKGILNKNSFIAPRYNTILGIKPLDDKVLTPISIDYIIKYFSYEPITVYGDKDIESTKNMVKSVLGENLEAVTVSDYAVKLETHLNDIRFKIAFEITKTLILTILTILSIVMTLVFKVKMSHDIIGTLYSIGISKKKVFCIFAREFLSFIVIAIGLGYVFYIKNSEYIFRVFYNKYKYSSLAVSTVVLIIILITSLKIIFNRINRLTPKEIMGGFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL7</accession>
    <name>A0A386PFL7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_00135</name>
        <name evidence="7" type="ORF">EI377_10765</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 9">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="CP523_00135"/>
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        <property type="gene ID" value="EI377_10765"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE32969.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS61163.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    <sequence length="1084" mass="126356" checksum="0E316C133BB7462F" modified="2018-12-05" version="1"> </sequence>
</entry>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="209" mass="23785" checksum="06BC35BA8668D8C7" modified="2018-12-05" version="1">MKLLIFDTETTSVKPGHICQLSYILIDASTKPQTTTGKNFFFTVDEMDEGAEAIHGFSLEKLYELSNGQEFLDFVTEFMPDFFNADFIIGHNVQFDIKFLKHELQQLWEAGVIDTTWEPKNTFCTMAYYKNICNILNPNGNIKNPKLSEVIDYLGITEAQIASKADELFEGSGNYHDARFDTAATYLTVIQGMKKRLIPSGYFSNLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
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    <name>A0A386PFN1_CLOSE</name>
    <protein>
        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02840</name>
        <name evidence="3" type="ORF">EI377_13365</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676999.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00974"/>
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        <property type="protein sequence ID" value="AYE33476"/>
        <property type="gene ID" value="CP523_02840"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61647"/>
        <property type="gene ID" value="EI377_13365"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="53226" checksum="853F8FC875CE1402" modified="2018-12-05" version="1">MGDIIFSVTAVFQIFVFAITMYYFILAFMGLRRKDEKKNYKPEKKFAMIVAAHNEEVVIGKLIESMLNQNYPKELIDIFVIADNCTDNTAKIARKYGVNVYERFNDEQRGKGFALEWMFAKIFKMKKKYDAIAIFDADNLVSKNWCKEINSKMLEGYKVVQGYIDSKNPNDSWIATSYSIAFWSQNRMYQLARANVGLSNQIGGTGFAIDTEVLQKLGWGATCLTEDLEFSCKLVLNGEKVGWAHDAIIYDEKPLTLKQSWVQRRRWMQGFTDVASRYFFKLIKRGLKEKKWFILDCALYVIQPFLTLMLGISLLLTVLQVVSSNGLNIFLISYLFGDVLFKALAVIQFLITPLIMKLDNKISSGFFWMILFYSLSIFILPAILGDEGNMGTFILANVVYNGAFLLATGLFLGKKNLILFFRFLLYALYTLTWIPITIQGMLKKNNKDWNPTKHVRSIEICDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT4</accession>
    <name>A0A386PFT4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04250</name>
        <name evidence="3" type="ORF">EI377_14775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00427"/>
    <dbReference type="EnsemblBacteria" id="AYE33738">
        <property type="protein sequence ID" value="AYE33738"/>
        <property type="gene ID" value="CP523_04250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61895">
        <property type="protein sequence ID" value="QAS61895"/>
        <property type="gene ID" value="EI377_14775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="186" mass="21470" checksum="780C424BAF080282" modified="2018-12-05" version="1">MTWVHSIQNYVPYNNQELKDKELILSAINNYNNLLTRENVIMHITSSGYIVNKKRDKVLMIYHKIYNSWAWTGGHADGDDDLLYVAIKEAKEETGLKNVTAVTPEIFSLDVLTVDGHIKRGEYVSSHLHLNVTYLLEADEKEALTVNEEETKGVKWLPINELSKYCSEPYIIENVYNKLNKKINLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY0</accession>
    <name>A0A386PFY0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrogenase iron protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_11315</name>
        <name evidence="10" type="ORF">EI377_06135</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NifH/BchL/ChlL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673243.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02820"/>
    <dbReference type="EnsemblBacteria" id="AYE34953">
        <property type="protein sequence ID" value="AYE34953"/>
        <property type="gene ID" value="CP523_11315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60348">
        <property type="protein sequence ID" value="QAS60348"/>
        <property type="gene ID" value="EI377_06135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030655">
        <property type="entry name" value="NifH/chlL_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000392">
        <property type="entry name" value="NifH/frxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42864">
        <property type="entry name" value="PTHR42864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00142">
        <property type="entry name" value="Fer4_NifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000363">
        <property type="entry name" value="Nitrogenase_iron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00746">
        <property type="entry name" value="NIFH_FRXC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00692">
        <property type="entry name" value="NIFH_FRXC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51026">
        <property type="entry name" value="NIFH_FRXC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="252" mass="27210" checksum="C12968139245E30B" modified="2018-12-05" version="1">MVEKKVRKIAIYGKGGIGKSTTTSNLSAALSHLGFKVMQIGCDPKADSTKNLMGGKRIPTVLEQLKEKGDDLSLEDIVFNGYNGVLCVESGGPTPGIGCAGRGIISAFEKLEELEAFETYNPDVILYDVLGDVVCGGFAMPIRGGYAEEVYIVSSGEMMSLYAASNISSAIKNFRSRGYAKLKGLILNSKNIENEVSIVEKAVEEIETKITHVIPRSGEIQLAENKGGTVFELLENSEMKKVYTELANKIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG06</accession>
    <name>A0A386PG06_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03550</name>
        <name evidence="6" type="ORF">EI377_14075</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677939.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02261"/>
    <dbReference type="EnsemblBacteria" id="AYE33606">
        <property type="protein sequence ID" value="AYE33606"/>
        <property type="gene ID" value="CP523_03550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61770">
        <property type="protein sequence ID" value="QAS61770"/>
        <property type="gene ID" value="EI377_14075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="26346" checksum="AC85BB2D72184514" modified="2018-12-05" version="1">MRINKLLSNLGFCSRKETNRLIEENRIKVNGEYCIPGQWVEREDIILIDDKPIQEREKVYIALNKPVGITCTAAKEIKDNIISFINYPNYIFPVGRLDKASQGLIIMTNDGELANKILESENKHEKEYIVTVDKPFDDEFIKGMSSGVKIFETITRPCEVTRISKDTFKIILTQGLNKQIRRMSKVFGYKVIKLERIRIMNIKIDGIEIGKWRNLTEKEILELRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG28</accession>
    <name>A0A386PG28_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS transporter subunit IICB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_03660</name>
        <name evidence="16" type="ORF">EI377_14190</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677711.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02213"/>
    <dbReference type="EnsemblBacteria" id="AYE33626">
        <property type="protein sequence ID" value="AYE33626"/>
        <property type="gene ID" value="CP523_03660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61790">
        <property type="protein sequence ID" value="QAS61790"/>
        <property type="gene ID" value="EI377_14190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011300">
        <property type="entry name" value="PTS_IIBC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02003">
        <property type="entry name" value="PTS-II-BC-unk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="10"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="474"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="552" mass="60383" checksum="93D43D84B1C5164C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG33</accession>
    <name>A0A386PG33_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative pyruvate, phosphate dikinase regulatory protein</fullName>
            <shortName evidence="5">PPDK regulatory protein</shortName>
            <ecNumber evidence="5">2.7.11.32</ecNumber>
            <ecNumber evidence="5">2.7.4.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06820</name>
        <name evidence="7" type="ORF">EI377_01295</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43692"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43696"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="2.7.4.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.32" evidence="5"/>
    <dbReference type="EC" id="2.7.4.27" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679266.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00006"/>
    <dbReference type="EnsemblBacteria" id="AYE34194">
        <property type="protein sequence ID" value="AYE34194"/>
        <property type="gene ID" value="CP523_06820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59558">
        <property type="protein sequence ID" value="QAS59558"/>
        <property type="gene ID" value="EI377_01295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00921">
        <property type="entry name" value="PDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026565">
        <property type="entry name" value="PPDK_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="30277" checksum="6DC9E36F79E408E0" modified="2018-12-05" version="1">MLTIFAVSDSIGETAEQVAVAAASQFGNDVEVKRIPYVKTLEDVEELIKEIELCEKVMVVSTIITVNVREYLTQKGAEKNISVLNVLGPIINVASTIINKIPNYNPGAMWKTDEVYFKRIEAMEFAMQYDDSKDYRGLKNADVVLVGLSRTSKTPLCMYLANKGIKAINIPLVPEVGVPEEIYEIDKKKIFGLVINPLQLIEIRKRRLDKFHRIPADIEYASDARILEEFEFSDRIMRKLGCRTIDVTQRAIEDTALIIIKALGHDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG67</accession>
    <name>A0A386PG67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08350</name>
        <name evidence="3" type="ORF">EI377_03095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674770.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01611"/>
    <dbReference type="EnsemblBacteria" id="AYE34437">
        <property type="protein sequence ID" value="AYE34437"/>
        <property type="gene ID" value="CP523_08350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59840">
        <property type="protein sequence ID" value="QAS59840"/>
        <property type="gene ID" value="EI377_03095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="280" mass="31070" checksum="0539173C36456320" modified="2018-12-05" version="1">MQKIAILTDSASDLSIEILKENNIHLFPLRIIYSNEEFEDKITITPEEVYKKLPIEIPTTSLPSPKTSEKVLKKLEDEGYTHVIAISVSSGLSGTFNAFRLALEEHPNLISYVYDSKIIGFPQGVLVLEASRLVKNGQSFEDIIKELPKIRENITGYFTLNTLEYLKKGGRIGRLAGTIGQFLHLKPIITVDDNGVYYASNKVRGRKQSLSKMIEILQSHLNESKCNVWVLEGGCMDEVLAFSESIKSLDNVNFMGIMPVGAMVAVHSGPGMVGLAIQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG70</accession>
    <name>A0A386PG70_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF624 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05785</name>
        <name evidence="3" type="ORF">EI377_00270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01857"/>
    <dbReference type="EnsemblBacteria" id="AYE34011">
        <property type="protein sequence ID" value="AYE34011"/>
        <property type="gene ID" value="CP523_05785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59383">
        <property type="protein sequence ID" value="QAS59383"/>
        <property type="gene ID" value="EI377_00270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006938">
        <property type="entry name" value="DUF624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04854">
        <property type="entry name" value="DUF624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="26140" checksum="00F363BAF6E76D73" modified="2018-12-05" version="1">MHDAFNMQKIFDFFNYVFWFFLLNIFFMILNIPFILFFLFVGISNIFTYFPLFLVTLIPTGAAFTTLLFCMGKIVRDKDLSIVKDFIRGFKMNFKQSTILWCCELVLIFILHFNIRFFSTIKYNLLLTCIFSGLLIFMLLATPYIYILLSRFSMKNLDLIKASLILTFTRPILTICNVLIAAITLIFFEITPGTTVLFISSIFTFLLAFSNKALLKELEIGYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG85</accession>
    <name>A0A386PG85_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RnfABCDGE type electron transport complex subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_01305</name>
        <name evidence="11" type="ORF">EI377_11805</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675560.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00812"/>
    <dbReference type="EnsemblBacteria" id="AYE33189">
        <property type="protein sequence ID" value="AYE33189"/>
        <property type="gene ID" value="CP523_01305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61359">
        <property type="protein sequence ID" value="QAS61359"/>
        <property type="gene ID" value="EI377_11805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="297" mass="31783" checksum="61155BAA0F15A2E0" modified="2018-12-05" version="1">MGNTNLKISPAPHIKRGLGVNKIMIDFIIALIPAVFAGIYFYKGDAVKILLASVLASIISEALWNKFIKKTNWITDLSPIVSGIILGLIMPTYVPLWIPVIGAIFATIVVKQFFGGLGQNFMNPAAATKAFLIASWAAVMAKPVVDTTASASKAAQKVVPLIDRIIGQANGSIGEVSILALCIGGLYLAIRGVISLRASFTFIISAFAMYSYFGKEGLLPGAFFLAAIFMATDHATTPMTKVGQYIFGLAAGICASFIAVKGYNPEGPYYAIIILNLFTPLIEYFTTKKVKVKKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG97</accession>
    <name>A0A386PG97_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_08510</name>
        <name evidence="11" type="ORF">EI377_03260</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674855.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01643"/>
    <dbReference type="EnsemblBacteria" id="AYE34467">
        <property type="protein sequence ID" value="AYE34467"/>
        <property type="gene ID" value="CP523_08510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59870">
        <property type="protein sequence ID" value="QAS59870"/>
        <property type="gene ID" value="EI377_03260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="256"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="472" mass="53873" checksum="076E5E4D2C9C6474" modified="2018-12-05" version="1">MNKKGIAYKLTITFTSITAVILILIGMTLSIWFNREYKIERTYLLDKQLSLIEGATLSFLNDNTEVAYNELSKVLNMIESSIEIDSIIIDKLGYIYAVSNNKYNKEKYTRINLNDEELNKLKNGESINFNFKNYEGALKKSYIKPLFKDGYFYGAIVLIGDEAYTNPPKRIYIIIWLSVILALILSSVVTYYFSEKLIIKPLEEINNAAKKIAKGDVEKRVSIESGDEIGELGYSFNIMAESLEQVDKKRREFISNVSHELRSPITSIKGFITGILDGVIPRDKENYYLTIVNDEISRLARLVTDLLDISAMESGKFNLNMVDLDINEVITLCTLNLEGKVKEKNINVEVIFHDKHEYAIADRDRLIQVVTNLLENAVKYGEANGEIKIDTYVRGDKAYVSIFNSGPTIPKEEINNIWDRFYKSDKSRTNKFSMGLGLPIVRLILSQHGQDIWVNNIDGKGVRFTFSLKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB7</accession>
    <name>A0A386PGB7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sigma70_r4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673768.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34274">
        <property type="protein sequence ID" value="AYE34274"/>
        <property type="gene ID" value="CP523_07325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="449"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1119" mass="132771" checksum="802FE22C546DA647" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR6</accession>
    <name>A0A386PGR6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroK</name>
        <name evidence="3" type="ORF">CP523_11405</name>
        <name evidence="4" type="ORF">EI377_06220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673272.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02838"/>
    <dbReference type="EnsemblBacteria" id="AYE34970">
        <property type="protein sequence ID" value="AYE34970"/>
        <property type="gene ID" value="CP523_11405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60363">
        <property type="protein sequence ID" value="QAS60363"/>
        <property type="gene ID" value="EI377_06220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11405"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="166" mass="19083" checksum="31A02AC0C256385F" modified="2018-12-05" version="1">MGKKSIVLIGMPGCGKTTIGKILANEINYNFCDMDNYIEEISGKTVKELFEVSEEHFRDLETRACKELCNKKDLLVSSGGGVIKRKKNIDLFKDNSIIIFIDRPLEKIISDINASTRPLLKDGKDKLYKLYQERYNLYNEYSDIKVVNNGFIEDVILDIKDKLKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS6</accession>
    <name>A0A386PGS6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF5105 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09360</name>
        <name evidence="4" type="ORF">EI377_04105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34617">
        <property type="protein sequence ID" value="AYE34617"/>
        <property type="gene ID" value="CP523_09360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60017">
        <property type="protein sequence ID" value="QAS60017"/>
        <property type="gene ID" value="EI377_04105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031343">
        <property type="entry name" value="DUF5105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17118">
        <property type="entry name" value="DUF5105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362713" evidence="1">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5105" evidence="2">
        <location>
            <begin position="58"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="181" mass="20530" checksum="CF1D8F248BCA33F0" modified="2018-12-05" version="1">MKMKKGTLILSFFILILTLVGCKEEVHMDSKETVTFFIDSLCSGDFKSVDKVLKYPKYNKLITKDEKLKEMYSVLFAKCKVEILDIAENGNLATVNAKVNSVDLSKVEKYITANTRKILQDNNIETTGNKADDALLKETIKRIKDSSTGFKETKVNIYLEKENNQWIVTDEGELINAMEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU0</accession>
    <name>A0A386PGU0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YkuD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_09410</name>
        <name evidence="6" type="ORF">EI377_04155</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678042.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02741"/>
    <dbReference type="EnsemblBacteria" id="AYE34627">
        <property type="protein sequence ID" value="AYE34627"/>
        <property type="gene ID" value="CP523_09410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60027">
        <property type="protein sequence ID" value="QAS60027"/>
        <property type="gene ID" value="EI377_04155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09410"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362712" description="YkuD domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="227" mass="25839" checksum="DBEFA1D9540EC353" modified="2018-12-05" version="1">MKKKFNFLILTLILFIFLPSNFINANSLENNTEPKYIIYIDVNSFTLNLIDKQTKKIVKTYPVAVGKPKTPSPIGTWQITSKALMKDAYGGYWMGLNAPWDTFGIHGTNRPDSIGTMASGGCIRMYNHNVKELFNLVEYGTSVVISGGPNWRFSQYNRVIKPNDKGTDVYLVQVKLKALGYFPYDVNGIYELSLENAVLQYRSEHHLSETKEIDGEFLDSIGLWKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV1</accession>
    <name>A0A386PGV1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35303">
        <property type="protein sequence ID" value="AYE35303"/>
        <property type="gene ID" value="CP523_13195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="66" mass="7663" checksum="424C54362737CACF" modified="2018-12-05" version="1">MIVDKRHETTRKLTKIFEPYIIMGNAGDYLEATIREDAPQNVKDAHKEYIKITNEILRDKANSPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX7</accession>
    <name>A0A386PGX7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09595</name>
        <name evidence="3" type="ORF">EI377_04370</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676686.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02625"/>
    <dbReference type="EnsemblBacteria" id="AYE34657">
        <property type="protein sequence ID" value="AYE34657"/>
        <property type="gene ID" value="CP523_09595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60057">
        <property type="protein sequence ID" value="QAS60057"/>
        <property type="gene ID" value="EI377_04370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="245" mass="28983" checksum="9430C22A33A32D2F" modified="2018-12-05" version="1">MEFIDKNSRTPLYLQLMDILIENIEKKLEEHQQILSEREICERYDVSRTTVRQALDELERDGYIYKIHGKGTFVSPKRLNQDLVSFYSFTEEMKKIGKEPTSEVIGFEITHSGEKLSRKFKIQEKDLVYKITRIRKADNIPMMYEVTYLPFDRFEGLSKKYLEESPMYEVLISKFSAKLTSAEEYFEPILTNKLESIYLEIDEGSPSLKIERFTYENTNLIEYTVGVARGDKFKYRVQLNNNLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY4</accession>
    <name>A0A386PGY4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33812">
        <property type="protein sequence ID" value="AYE33812"/>
        <property type="gene ID" value="CP523_04655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022221">
        <property type="entry name" value="TypeIII_RM_meth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12564">
        <property type="entry name" value="TypeIII_RM_meth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015855">
        <property type="entry name" value="TypeIII_Mtase_mKpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0680">Restriction system</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TypeIII_RM_meth" evidence="6">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="194"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="620" mass="72218" checksum="973ECB63152D2C3B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ9</accession>
    <name>A0A386PGZ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04765</name>
        <name evidence="2" type="ORF">EI377_15275</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675794.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01719"/>
    <dbReference type="EnsemblBacteria" id="AYE33832">
        <property type="protein sequence ID" value="AYE33832"/>
        <property type="gene ID" value="CP523_04765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61978">
        <property type="protein sequence ID" value="QAS61978"/>
        <property type="gene ID" value="EI377_15275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="85" mass="10163" checksum="563DF7429EE5EF63" modified="2018-12-05" version="1">MDTAIEKAEQKIEYLSSDEEVMRIYYERERSLHERANMINSAEARVIEQGKKEEKKNIPSEILSVVKCLYSDWDYFFYILSNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH37</accession>
    <name>A0A386PH37_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative sulfate exporter family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_13675</name>
        <name evidence="9" type="ORF">EI377_08565</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677179.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02087"/>
    <dbReference type="EnsemblBacteria" id="AYE35393">
        <property type="protein sequence ID" value="AYE35393"/>
        <property type="gene ID" value="CP523_13675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60782">
        <property type="protein sequence ID" value="QAS60782"/>
        <property type="gene ID" value="EI377_08565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="338" mass="36942" checksum="A4C2559BA2F3A365" modified="2018-12-05" version="1">MIEKIKRIIPGLIICLVVGIVAEILGSHFTTIGAASFAIFIGIVLGNTIFHNKKYDSGTKFAEKDLLNYSIVLMGANLNLAEILQLGFGGLIFIVIQMTLTMTVTYWIGRKLKFNRKYCLLMSSGNSVCGSSAIGATAPVINANDSDKVISITIVNVIGTILMIILPLITAVLYNNSTLETSAMMGGILQSVGQVIGSAKFVSDDVVKLATVFKIIRIILIVAVVLIYERIEFPEDKEIHKNKEVSKVKKKGKINIPWFITGFFLVCILNTLGVVPEFISKSFKWISGNFEIIALAGIGMRVKVKDLVKEGPRAMLYGLLVGGCQIIFAITLIKFLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH84</accession>
    <name>A0A386PH84_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03180</name>
        <name evidence="4" type="ORF">EI377_13695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02147"/>
    <dbReference type="EnsemblBacteria" id="AYE33539">
        <property type="protein sequence ID" value="AYE33539"/>
        <property type="gene ID" value="CP523_03180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61702">
        <property type="protein sequence ID" value="QAS61702"/>
        <property type="gene ID" value="EI377_13695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anaer_Co_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="29583" checksum="1B747699A7815452" modified="2018-12-05" version="1">MSKAIIIASFGTTDLEALKNLDKIEDEVRVRINKKYPVIRVFTSKTIINSLKVKHNISVLKLDEALFKLSSEGFEEVIIQPLHIMECLEYEEIKKVIYSYDYTFKSIKIGKTLLGYYGSELENACDRLICAMDEELPKDKNIVLVGHGSKTITTEAYYILESKFRDKGYSNLLIGTLEGDRTRDFIVDKLKNENIDEVLILPLLVIAGNHAKLDIAGDEKSWKSKFLEEGIKVDINLKALLEYKKVRNLYINQIERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH87</accession>
    <name>A0A386PH87_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05500</name>
        <name evidence="2" type="ORF">EI377_00120</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33966">
        <property type="protein sequence ID" value="AYE33966"/>
        <property type="gene ID" value="CP523_05500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59357">
        <property type="protein sequence ID" value="QAS59357"/>
        <property type="gene ID" value="EI377_00120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032721">
        <property type="entry name" value="Toxin-deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14424">
        <property type="entry name" value="Toxin-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="110" mass="12637" checksum="57CD88B7E8A4EB4A" modified="2018-12-05" version="1">MHKIQSLDDISDEVATRLNGISFKPENQQFKTLNINKDNVVDGINSWNRNVDTEFKIIEDTSGKLGDNVNAKGNITLYTDLYPCPSCQYVIEQFMKKYSNIKVDIIYKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA5</accession>
    <name>A0A386PHA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_03285</name>
        <name evidence="12" type="ORF">EI377_13800</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02127"/>
    <dbReference type="EnsemblBacteria" id="AYE33559">
        <property type="protein sequence ID" value="AYE33559"/>
        <property type="gene ID" value="CP523_03285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61722">
        <property type="protein sequence ID" value="QAS61722"/>
        <property type="gene ID" value="EI377_13800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011081">
        <property type="entry name" value="Big_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07532">
        <property type="entry name" value="Big_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1905"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="domain" description="Big_4" evidence="6">
        <location>
            <begin position="248"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_3" evidence="10">
        <location>
            <begin position="508"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_101" evidence="7">
        <location>
            <begin position="746"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hyd_101C" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="GalBD_like" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1866"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1637"/>
            <end position="1710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1929" mass="214357" checksum="AAB6014368540919" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC0</accession>
    <name>A0A386PHC0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_08475</name>
        <name evidence="7" type="ORF">EI377_03225</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674833.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01636"/>
    <dbReference type="EnsemblBacteria" id="AYE34461">
        <property type="protein sequence ID" value="AYE34461"/>
        <property type="gene ID" value="CP523_08475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59864">
        <property type="protein sequence ID" value="QAS59864"/>
        <property type="gene ID" value="EI377_03225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08475"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="272" mass="29768" checksum="79C6A75BD5A54729" modified="2018-12-05" version="1">MDLSNKLQVASQFILEKTNYKPEIGLILGSGLGSLADSIENPEYYDYKDLPHFPTSTVEGHAGRLVIGMLNGKCVVAMQGRFHYYEGYAYNEVTFPVRVMKLLGVEKLVVTNAAGAVNTSYVPGDLMLITDHLNLSGDNPLIGKNLEKFGPRFPDMSNAYNVELRNKALEIAKKLNMDIKQGVYAMMSGPTYETPAEVRMVRILGGDAVGMSTAPEVIIANHCGMKVLGISCMTNMAAGILEQPLDHEEVIVTSNMVREKFIALMSEIISAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF0</accession>
    <name>A0A386PHF0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07555</name>
        <name evidence="2" type="ORF">EI377_02245</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673819.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01120"/>
    <dbReference type="EnsemblBacteria" id="AYE34308">
        <property type="protein sequence ID" value="AYE34308"/>
        <property type="gene ID" value="CP523_07555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59702">
        <property type="protein sequence ID" value="QAS59702"/>
        <property type="gene ID" value="EI377_02245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="105" mass="11888" checksum="998484E45D357427" modified="2018-12-05" version="1">MKREDLNIMANIKMIEKLKANLLCIIGEFYYLLTKGSNVAQDAILNCISGSILILYVLGQKLGYSCDDVDDDMKKKLRAGIAEGHEYEKDGRSLSKLQEHLKKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF1</accession>
    <name>A0A386PHF1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mac-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675013.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01876"/>
    <dbReference type="EnsemblBacteria" id="AYE34026">
        <property type="protein sequence ID" value="AYE34026"/>
        <property type="gene ID" value="CP523_05865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015117">
        <property type="entry name" value="IdeS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09028">
        <property type="entry name" value="Mac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017428905" description="Mac-1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Mac-1" evidence="2">
        <location>
            <begin position="118"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="418" mass="47659" checksum="4750EC49B9123E9C" modified="2018-12-05" version="1">MIKKNKIISAILLSSILSLNFSKTLTTYADLTTLNYDSKYDLNNDSIINELDIDEISKHYNNQKDSADWAEEFDFNNDGIIDIFDIIKISKRNGIKKPEKNLSKNALELQNLLAANKNVTTTEDEAGKTIYNVWVKGITPPTESDFTTLNLGANYSINVAPWKPGQGWYDINKVRGESGDNLFCSGAVATNMLHWWLDQNKEYIDRYLAQNPENGKNLDKSLDIRTSSTFHDQKNSDIFNLVKKYFRNNVLSSVKTLLWYINGSSIGLPTSPYIDTRAGFISGIFKQEDLIDVCYIGPYDLLNIRLLEWLQEDKVLGISYENAGVNYNHIITLWGANFDEAGNLLGIYVTDSDDEKSKISKDVLYGMKYYRTVKDPNGRARITTYNGKENNRGAKLSVLYSFNLGKDQWEEYFNKDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH6</accession>
    <name>A0A386PHH6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_10715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674122.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01359"/>
    <dbReference type="EnsemblBacteria" id="AYE34837">
        <property type="protein sequence ID" value="AYE34837"/>
        <property type="gene ID" value="CP523_10715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="451" mass="50505" checksum="73635EC04F02B9F2" modified="2018-12-05" version="1">MRRGSALQVKIEKTEFPSVGIGTVGDKKIFVKGAFPGQIVTGKVKKRRQEYAELKLLSVDEKADYEIEAPCKYFGICGGCSSQNLTYEKQLELLNGEVKNLFEKGNAPMGEYLGVVGSKNQWEYRNKMEFTFGDFEKGGELTLGMHMKGKSFGIITVDNCMIVDEDFRTVIKATVDYFKDKELPYYRVMRREGYLRHLVIRKAINTGELMVNLVTTTQIDFDLTEYVEVLKSRIYKGQLVSVLHTENDSFSDAVVPEKVNLLYGKDYIVENLLGLKFKISPFSFFQTNTQGAESLYSIVRDFMGESSDKVVFDLYCGTGTIGQIAAANAKKVIGIELIEEAVEAAKENAKLNGLNNCEFLAGDVGEIIKTIKVKPDIIILDPPRSGVHPKALEYVIKFNAKEIIYVSCNPKTLVENLETLVASGYEVIKSTVKDMFPNTPHAETVVKLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ9</accession>
    <name>A0A386PHJ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07935</name>
        <name evidence="2" type="ORF">EI377_02695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00702"/>
    <dbReference type="EnsemblBacteria" id="AYE34358">
        <property type="protein sequence ID" value="AYE34358"/>
        <property type="gene ID" value="CP523_07935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59763">
        <property type="protein sequence ID" value="QAS59763"/>
        <property type="gene ID" value="EI377_02695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="471" mass="52396" checksum="AF4A902BF7E96550" modified="2018-12-05" version="1">MSVKDKKYDVIIVGAGPSGIFTAYELNKIHPEKKILIIEKGKSVHKRSCPIPIINKCIKCKPYCNITTGFAGAGAFSDAKLSLYDSEVEEVLVGGNLPNVIGHLKTKKLIDYCDKVYLDFGGEKNISGVENKAEIKSIKNNAKNHNINLVDIPIRHLGTEKSRELYGKLEDYLRRQGVEMLFETPVNDLIIDNGEILGVTTENDSFYGEKTVISVGRNGADMLSDLCDRYGIEKEVGIVDIGVRFEMRSEGDIKRINELMYEGKFIGKVAPFKDKVRTFCQNPDGFVAAEVYDNGLSLVNGHAYKEKKSINTNFAILCSHNFTEPFNKPIEYAHKVAELTNLLSNGEVVVQRFGDILKGKRTWQEELDKNSVEATLKTAMPGDITLGIPYRTMTNIINFILEMDKVVKGFADPDNLLYGPEIKFYSNAIKLGENLETNIKNLYAIGDGAGLTRGLMMASCSGVYLARNLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV5</accession>
    <name>A0A386PHV5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678776.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35695">
        <property type="protein sequence ID" value="AYE35695"/>
        <property type="gene ID" value="CP523_15345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046078">
        <property type="entry name" value="DUF6096"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19591">
        <property type="entry name" value="DUF6096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="131" mass="14778" checksum="98BF8DA751E857FD" modified="2018-12-05" version="1">MALYKILTVGEKEYKLKLTTSATICIEEKLGCNILDPILEMGSSAPMDNKGNINMKKVTKIPIPSLKYLVTVLWGSLQKFHHGMTFEKTCDLLDEYIESGKTQMDLFEFIMNLLTESGILGTPEEKTENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX2</accession>
    <name>A0A386PHX2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34774">
        <property type="protein sequence ID" value="AYE34774"/>
        <property type="gene ID" value="CP523_10370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="102"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="252" mass="29211" checksum="29C892B8108D7601" modified="2018-12-05" version="1">MVTNSAYMQLINNLEYLKLKQMVNHLDEVIDFSTKNKLSFVDTLIKLTSHEIDCKEANMIRSMVKVGAFPHTKELKDFDFNFQPGINQDQILDFASLRFLEAKENIVFLGTSGVGKTHLSTSIGIAAAKRRCSTYFIKCNDLLQQLKRANLENRLDSRLKHFSKYKLLIIDELGYLPIDKEDSKLFFQLIDMRYEKKSTIITTNINFNAWDEIFCDPIIANAILDRVLHHAHVVSITGNSYRLKDHFNFEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI02</accession>
    <name>A0A386PI02_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavocytochrome c</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_07095</name>
        <name evidence="7" type="ORF">EI377_01840</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673702.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01034"/>
    <dbReference type="EnsemblBacteria" id="AYE34236">
        <property type="protein sequence ID" value="AYE34236"/>
        <property type="gene ID" value="CP523_07095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59641">
        <property type="protein sequence ID" value="QAS59641"/>
        <property type="gene ID" value="EI377_01840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034114009" evidence="4">
        <location>
            <begin position="30"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="31"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="474" mass="49956" checksum="243841506C011942" modified="2018-12-05" version="1">MKKKLLALVMSVAIAIPAVSFVGCGSTQSADVVIIGAGGAGLAAAVQAKQDGAKNVVVLEKMPLVGGNTNRASSGINAAGTKYQEEKGIEDSVETMIEDTMKGGHQKNNPDLVKKLAEDSNGSIEWLTDLGADLTDVGRMGGASVDRCHRPTGGAAVGAHLVDTLKKAAEKKEVDVRLWNKAEEVVLDKEGKVSSVKATNKEGKEYVINTKAVVITSGGFSANQELVVKYNPALKGFSTTNHNGATGDCIEIAEKLGADFVDMKEIQTHPTVVPEKAVMIAETVRGNGAILVNKEGNRFFNELDTRDAVSKAILSQKDGMAYIIFDDGLRKGLKQAEEYFNMGLVTEGDSIEDLAGKLEMDGATLKATIEKYNGFVSAKNDSDFGRTSMKKELNEGKFYAIPVAPAVHHTMGGIKIDTNAKVVNKDGNTIPGLFAAGEVTGGVHGANRLGGNALADIIAYGRTAGKNAVDFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI13</accession>
    <name>A0A386PI13_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">CP523_13945</name>
        <name evidence="8" type="ORF">EI377_08835</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678811.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00156"/>
    <dbReference type="EnsemblBacteria" id="AYE35440">
        <property type="protein sequence ID" value="AYE35440"/>
        <property type="gene ID" value="CP523_13945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60827">
        <property type="protein sequence ID" value="QAS60827"/>
        <property type="gene ID" value="EI377_08835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13945"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="49"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="297"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="398" mass="44369" checksum="922DED2B0FEEC800" modified="2018-12-05" version="1">MNLLIKNANVIDAMQNFYGDIYIEEGKIKEIGKELKIDNVDKIDAKGLTLMPAFIDTHAHFREPGLTYKEDIKTGSKAALRGGYTGVCLMANTSPICSSKEVLDTVRNRSKEISLIDIHQCVSVTKNFDGRTVEHLDELKGDKEIKAISDDGVGVMDSFIMYEAMKKAKENNWIIMSHAEDHKFSKTDMRIAENMMTLRDIALAKESKARLHMAHVSTKEAINYIKEAKDDGVNLTCEVTPHHIALTTKINNYRVNPPIREQEDVDAILKAIKLGVVDCIGTDHAPHTEEDKKKGSPGMVGLETAFSICYTILVRNNIIGINKLSEIMSKNPAKILGMNKGIISIGLDGDLVLVNLNKKVKINSNEFHSKGRNTPFDGMEFYGEVEMTIKGGRILYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI34</accession>
    <name>A0A386PI34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4956 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07285</name>
        <name evidence="3" type="ORF">EI377_02035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673751.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01074"/>
    <dbReference type="EnsemblBacteria" id="AYE34266">
        <property type="protein sequence ID" value="AYE34266"/>
        <property type="gene ID" value="CP523_07285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59672">
        <property type="protein sequence ID" value="QAS59672"/>
        <property type="gene ID" value="EI377_02035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
        <property type="entry name" value="DUF4956"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16316">
        <property type="entry name" value="DUF4956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="25919" checksum="AEEC5835AA28036E" modified="2018-12-05" version="1">MLERLFTSSVAETLTLRGTIIIVFAALLLGLGISLVYRYIHREEDYSASFTVTLIMLPAIIAMIIFLVGSNVARAFSLAGAFSLIRFRSAPGDAKDIAYVFFTLGVGLACGMGYIGYAVLFAVIICMVMYILYKVEFDVDKRRSMRLKIILPEDMEYEGAFDEIMKKYTYNYKLVGVKTKEFGSLFELLYEVVLKPETQSKVFIDELRCKNGNLNIMLGMKESKENLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI65</accession>
    <name>A0A386PI65_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07420</name>
        <name evidence="5" type="ORF">EI377_02110</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673788.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01093"/>
    <dbReference type="EnsemblBacteria" id="AYE34292">
        <property type="protein sequence ID" value="AYE34292"/>
        <property type="gene ID" value="CP523_07420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59686">
        <property type="protein sequence ID" value="QAS59686"/>
        <property type="gene ID" value="EI377_02110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="190"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="406" mass="44946" checksum="B0CCD9025F55BD19" modified="2018-12-05" version="1">MVSKKDAVGVTVKIVLLFIPVITILNTNKSYILEAYLNNSVIGYVDSRAETREVFSEVLEEINIDSKSPEINNERIRYTKITEGNVALSNKSEIKKNILEALTGKASAYALSLSGEKLGYMASNDTVNNILKLATDKHINELNIDRTDVISADIVCNVNLQEETTDISSIKTEEELADKIYNISKENTDLVQIKIKTKEIVEEIVSPKTVTSLDENLYIGESRIEEGEEGIKKVLKEVTYKNEKQENNNILEETIIKEPVNTIIHKGSKNPYKDGVAFLLHPTVGKTVTSGYGERWNSFHKGIDIASNIGDKVNAAIEGKVTYAQYNDGGYGNLIIIEHEGNMTTYYAHLSEIYAKLGDIVNTGDLIGAVGNTGFSTGPHLHFELRVNGLPVDPSNYILKQENKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE3</accession>
    <name>A0A386PIE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09415</name>
        <name evidence="3" type="ORF">EI377_04160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678044.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02742"/>
    <dbReference type="EnsemblBacteria" id="AYE34628">
        <property type="protein sequence ID" value="AYE34628"/>
        <property type="gene ID" value="CP523_09415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60028">
        <property type="protein sequence ID" value="QAS60028"/>
        <property type="gene ID" value="EI377_04160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="212" mass="23559" checksum="05A547E74287D2C0" modified="2018-12-05" version="1">MDKVKKWKLECDGKKLVDILNERKYNAIYVDNVMEAKEKVLELVPEGSSIALGGSVTLNEMDLVNTIRNGNYKFYDRYQDLPFVEIVEIMRQSMVADYLITSTNAVTEAGELVNMDCSGNRAAGMIFGPKKVIVVIGANKMVKDMDEALARIKKVAIMNAKRINHKTPCAESGICEDCFVKGRVCNYLSVVNNGAKFPGRFTVIVVGDEVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII1</accession>
    <name>A0A386PII1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0735 ACT domain-containing protein CP523_08245</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08245</name>
        <name evidence="4" type="ORF">EI377_02995</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0735 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674718.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01591"/>
    <dbReference type="EnsemblBacteria" id="AYE34416">
        <property type="protein sequence ID" value="AYE34416"/>
        <property type="gene ID" value="CP523_08245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59821">
        <property type="protein sequence ID" value="QAS59821"/>
        <property type="gene ID" value="EI377_02995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00707">
        <property type="entry name" value="UPF0735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008310">
        <property type="entry name" value="UPF0735_ACT_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025624">
        <property type="entry name" value="ACT_PheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="146" mass="16303" checksum="32825BAFF1D2480B" modified="2018-12-05" version="1">MAGEKYYIISEKALPEAFKKVIEVKELLFTGKAKDISDAVKQTNISRSTYYKYKDDIFPMSEGIHSKKITLVVLLSHEAGTLSKVLDCIAFNKGNIITINQDIPINMAANVTITLDISNMKKDLKQLVNILRSLPNVVSVKLLAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ7</accession>
    <name>A0A386PIJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09895</name>
        <name evidence="4" type="ORF">EI377_04680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34688">
        <property type="protein sequence ID" value="AYE34688"/>
        <property type="gene ID" value="CP523_09895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60089">
        <property type="protein sequence ID" value="QAS60089"/>
        <property type="gene ID" value="EI377_04680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="110"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="312" mass="35358" checksum="ADE9B90DC4832008" modified="2018-12-05" version="1">MKKSKKMIKRKKQKNFIIFVSALIFCVFAVIFLSTKLKNDTIDIKADEIENKNSSENPKTSEVNSDKPKEVTLDNSNYLSLKDDPNADDASVVLPETMYKWNFQRTDGKKIAYLTFDDGPSENVTGKILDTLKDNNIKATFFTLGSAIEENPKSGELLKRMVKEGHAIANHGYSHDYKILYPNGSVDVNSFMNDMEKNRKILKEKLGKDFDTRVIRLPGGHGTWDGVSALDAELSKQGLYQVDWNSLNGDAEANNRSTEELIGRLRETIDQFDYDTVIVLMHDSAGKKTTAEYLQNAIDYLRAKGFEFRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK5</accession>
    <name>A0A386PIK5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Bacitracin ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11140</name>
        <name evidence="6" type="ORF">EI377_05930</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677064.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00912"/>
    <dbReference type="EnsemblBacteria" id="AYE34921">
        <property type="protein sequence ID" value="AYE34921"/>
        <property type="gene ID" value="CP523_11140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60315">
        <property type="protein sequence ID" value="QAS60315"/>
        <property type="gene ID" value="EI377_05930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="34117" checksum="84C5B71F783612E5" modified="2018-12-05" version="1">MSENILVTRNLCKNYGKTVVLDNINMTVKKGSIYGLVGKNGAGKTTIVRMALSLANITAGEIELFNKTTEREKVIQHSRIGAMIETPAFFPGLTAKQNLEYYRIQRGIADKSSVDEALKLVGLSDAGRKKFKGFSLGMKQRLGLALALLGNPDFLILDEPINGLDPIGIKEIREILLELNKIKDVTILISSHILGELSQLATNYGFINSGKLVEEISAEELEERCKHCLSIKVDNVEKASIILEKELNCKDYEILNDGLIKVYKHLDEPYLVNSKLVKNDIKVYSLERTGSNLEEYFLELVGGNQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL9</accession>
    <name>A0A386PIL9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate:proton symporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GntP family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12780</name>
        <name evidence="3" type="ORF">EI377_07655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678183.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02793"/>
    <dbReference type="EnsemblBacteria" id="AYE35227">
        <property type="protein sequence ID" value="AYE35227"/>
        <property type="gene ID" value="CP523_12780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60622">
        <property type="protein sequence ID" value="QAS60622"/>
        <property type="gene ID" value="EI377_07655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="418" mass="42035" checksum="B6ECDF37E984D16F" modified="2018-12-05" version="1">MEITVTALGAVIALVVAITLIIKKVHPAYGLIIGALIGGLVGGAGLTGSVTLMMNGAKGMIPAILRILTAGVLAGVLIESGAAAKIAETIVSKIGESKALIALTIATMVLTAVGVFVDVAVITVAPIALAIAYKSNLSKSAILLAMIGGGKAGNIMSPNPNTIAAADNLGVSLTSVMIAGVIPAIFGVIVTCIIAKRLKVKGTFVGNDENTKEIENMPGFFPAIVGPLTAIILLMLRPTLGISIDPLIALPVGGLCGIIAMGKVKHLNEYATYGLGKMSGVAILLIGTGTLAGIISNSGLKDVIIQGINTLGLPNFALAPVSGILMSAATASTTSGTAVATSVFGPTITGMGVSSLATAAMVHVGATVLDHLPHGSFFHATGGSINMSMKERLKLIPYESLVGLTMTIVSVIIFGFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP3</accession>
    <name>A0A386PIP3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10210</name>
        <name evidence="2" type="ORF">EI377_05015</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674338.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34748">
        <property type="protein sequence ID" value="AYE34748"/>
        <property type="gene ID" value="CP523_10210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60148">
        <property type="protein sequence ID" value="QAS60148"/>
        <property type="gene ID" value="EI377_05015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="25456" checksum="E9344421EF9E0D22" modified="2018-12-05" version="1">MKKKFKLIPFIIFSLLFIEAIPFVEEKSQNSFNTIENKVMEECDFVQNGIKMEYVSQSTFKDEQYRLLMELKKNIKDDIQLNKNKIIYKDLEKEITVNIWEEKNKTKVEIIYLNNKNTKKSADLKKELVKFQNNKSIQVRYFTFIKGKIKTSDENYVQELLKNYIKEGTLESLDIHNGYVAKAKLRDNQRVNVGNVKYDTGEYIVVGTPMIFITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP6</accession>
    <name>A0A386PIP6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent Clp protease ATP-binding subunit ClpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_08790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02699"/>
    <dbReference type="EnsemblBacteria" id="AYE34506">
        <property type="protein sequence ID" value="AYE34506"/>
        <property type="gene ID" value="CP523_08790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="9">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="8">
        <location>
            <begin position="425"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="421"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="817" mass="92744" checksum="AB35A7B7FE41A44D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ01</accession>
    <name>A0A386PJ01_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein CP523_12610</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12610</name>
        <name evidence="10" type="ORF">EI377_07515</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01990"/>
    <dbReference type="EnsemblBacteria" id="AYE35194">
        <property type="protein sequence ID" value="AYE35194"/>
        <property type="gene ID" value="CP523_12610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60598">
        <property type="protein sequence ID" value="QAS60598"/>
        <property type="gene ID" value="EI377_07515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024560">
        <property type="entry name" value="UPF0313_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11842">
        <property type="entry name" value="DUF3362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="296"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="683" mass="77744" checksum="1A8968B3F0C26899" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ45</accession>
    <name>A0A386PJ45_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06690</name>
        <name evidence="2" type="ORF">EI377_01155</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679212.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34179">
        <property type="protein sequence ID" value="AYE34179"/>
        <property type="gene ID" value="CP523_06690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59542">
        <property type="protein sequence ID" value="QAS59542"/>
        <property type="gene ID" value="EI377_01155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="142" mass="16229" checksum="51CF503CA6C87283" modified="2018-12-05" version="1">MKYLLFIALISGLVGTYFYYDHKLALTRKQLMIASKRNNKLKSRATPKKNLDIKINFSNPTSKIGLTNINTNLYLAPINSSPIIRTIKIRMEVQILDAAETNSQTWYYVNLPIDSNINCRGWLNSTDFSILYSDSTNITKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB2</accession>
    <name>A0A386PJB2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">treR</name>
        <name evidence="2" type="ORF">CP523_07250</name>
        <name evidence="3" type="ORF">EI377_02005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673745.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01067"/>
    <dbReference type="EnsemblBacteria" id="AYE34259">
        <property type="protein sequence ID" value="AYE34259"/>
        <property type="gene ID" value="CP523_07250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59666">
        <property type="protein sequence ID" value="QAS59666"/>
        <property type="gene ID" value="EI377_02005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012770">
        <property type="entry name" value="TreR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02404">
        <property type="entry name" value="trehalos_R_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="236" mass="27597" checksum="A116C0A7E5AFC087" modified="2018-12-05" version="1">MDKKYLNIYNTIVNQIENNEYQANDKLPSEKDIMNNYNVSRDTVRKALNMLEQNGYIQKTKGKGSFVLDIGKFNFPVSGVVSFKELAEKLGMNVDTDVKDLECIIPKKNIARGLELNEYDKVWRVVRVRSIDNEKVILDKDYIVEKFVENLTHDVCKESLYKYIEGELGLKIAYAKKEITVQNATEEDKKHLDMKGFEMIVVVKSYIYLDDTSLFQYTESRHRPDKFVFVDFARRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJC9</accession>
    <name>A0A386PJC9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanophycinase</fullName>
            <ecNumber evidence="4">3.4.15.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_10050</name>
        <name evidence="10" type="ORF">EI377_04850</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate</text>
            <dbReference type="Rhea" id="RHEA:12845"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13734"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137991"/>
            <dbReference type="EC" id="3.4.15.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.15.6" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676571.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00339"/>
    <dbReference type="EnsemblBacteria" id="AYE34716">
        <property type="protein sequence ID" value="AYE34716"/>
        <property type="gene ID" value="CP523_10050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60117">
        <property type="protein sequence ID" value="QAS60117"/>
        <property type="gene ID" value="EI377_04850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011811">
        <property type="entry name" value="Peptidase_S51_cyanophycinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032067">
        <property type="entry name" value="Cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02069">
        <property type="entry name" value="cyanophycinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR032067-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="278" mass="30442" checksum="4585C94407C29E5D" modified="2018-12-05" version="1">MREKISGNLIIIGGAEDKEGDKEILKKVCNSIDKDKDTILIATIATEYPKEALQKYTKVFNGLGVKNIQNLDITNRNQSFDKKNIENIDKANLIFFTGGDQLRITSLVGGTPIYDGLKRASERGCIIVGTSAGASVMSDTMIVQGEDEESPRKCTLKMSPGLGFVDNVIIDQHFAQRGRIGRLLTGIAQNPEVLGIGIDEDTAIVVTDTGIAEVIGTGAVYFVDASCITHSNVSEQHGDEVLSMFNVKLHVLNEGKKFNLLKKSPFEEENCRYENDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJM0</accession>
    <name>A0A386PJM0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14020</name>
        <name evidence="5" type="ORF">EI377_08925</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678643.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00221"/>
    <dbReference type="EnsemblBacteria" id="AYE35454">
        <property type="protein sequence ID" value="AYE35454"/>
        <property type="gene ID" value="CP523_14020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60842">
        <property type="protein sequence ID" value="QAS60842"/>
        <property type="gene ID" value="EI377_08925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
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        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="24212" checksum="BF00EE1E788371C2" modified="2018-12-05" version="1">MSYITIRDFGEDRFIEKKSEFIGYAKRCETEEEAKAFVSEIKNMHKQARHNCWAYIIGENMGTQRYSDDGEPQGTAGIPILEVMKKSDITDCAVVVTRYFGGVLLGAGGLTRAYTKGAAIALKAGGVVEKVLGVKLSSTMDYDMLGKIQYICGQNNWYIEDVEYSDKVKVNILAELTSVNEMESKFVEVTNGKIENVKSDEEIYFKEENRLFKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN2</accession>
    <name>A0A386PJN2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13830</name>
        <name evidence="2" type="ORF">EI377_08725</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677127.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35421">
        <property type="protein sequence ID" value="AYE35421"/>
        <property type="gene ID" value="CP523_13830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60809">
        <property type="protein sequence ID" value="QAS60809"/>
        <property type="gene ID" value="EI377_08725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="63" mass="7319" checksum="B8A245B990916B17" modified="2018-12-05" version="1">MACIKEFKSDKCDLTAICLNYPDTEEEFQTLSNVFYKSMIEGLERQFGTNWGTEVMKKVKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU8</accession>
    <name>A0A386PJU8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M3 family oligoendopeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Oligoendopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00370</name>
        <name evidence="2" type="ORF">EI377_10860</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35787">
        <property type="protein sequence ID" value="AYE35787"/>
        <property type="gene ID" value="CP523_00370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62207">
        <property type="protein sequence ID" value="QAS62207"/>
        <property type="gene ID" value="EI377_10860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="563" mass="67145" checksum="F92BA77272C38534" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ2</accession>
    <name>A0A386PJZ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34946">
        <property type="protein sequence ID" value="AYE34946"/>
        <property type="gene ID" value="CP523_11275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="86" mass="10246" checksum="3C25F7C2F83D5B91" modified="2018-12-05" version="1">MKTALKILFFLPTIIFAILIILDLFDFTYELFKFKKTSSKLKFKYISKIETNNKLFLIYGIIIILITIFSRHIDFYSFAGLYFIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK03</accession>
    <name>A0A386PK03_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">CP523_14660</name>
        <name evidence="10" type="ORF">EI377_09625</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678858.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00142"/>
    <dbReference type="EnsemblBacteria" id="AYE35571">
        <property type="protein sequence ID" value="AYE35571"/>
        <property type="gene ID" value="CP523_14660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60957">
        <property type="protein sequence ID" value="QAS60957"/>
        <property type="gene ID" value="EI377_09625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="194" mass="21419" checksum="A058E9B7010EE143" modified="2018-12-05" version="1">MANLEFNKRDNTISNSAKKARRSGMVPGVLYGNKMKNMMFEVGELDLAREIACQGEHGILNFNLTGENHKALVKDVQRDPVSHKIIHLDLEELKGNQNIISSVPIHYVGEELLTKRGVVLQKEKDSVRVECSADSLPKYVEIKVNGGGVGSVYKFGDLEIASEISIVDDLNSVIASVSYERKTVADDMEVASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK38</accession>
    <name>A0A386PK38_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5808 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11805</name>
        <name evidence="4" type="ORF">EI377_06625</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673410.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35042">
        <property type="protein sequence ID" value="AYE35042"/>
        <property type="gene ID" value="CP523_11805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60435">
        <property type="protein sequence ID" value="QAS60435"/>
        <property type="gene ID" value="EI377_06625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043831">
        <property type="entry name" value="DUF5808"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19124">
        <property type="entry name" value="DUF5808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5808" evidence="2">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="376" mass="43574" checksum="F95C150282484D63" modified="2018-12-05" version="1">MERYIPWVIVNIMILTMFIISYYVNKTSNNGIFFGVRIPKEYQNKSEIINLDNEYKKINIIVFLVIAVISNFLFAYTINLKEEVLAVILVSIVMIILVLHSVIFVIYYKKMKNLKSSKGWNRKVKNVVVVDTTLRKPKRNEKIKIINSKYFALLFIFPVVMAIITLFKYSSLPNITDFPNSGFKNIEKDTLKGMLTLYQFPIAQLFMSSIFFFISKTIINSRVDLNSGSIKEAVERKKRFKRISSILMLFTAVEILILFSILQFSILYNFNSGIIEFIFTIIMLVTMIVFIGLFIKVGQGGRNLESKEEIDELYKDDDEKWILGCLYYNKNDPAWMVEKRVGIGWTINLANPKGIIILIVLLIIIFFMVIIGGIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK45</accession>
    <name>A0A386PK45_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cauli_VI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>unnamed1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
            <plasmid evidence="3">unnamed1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023672">
        <property type="protein sequence ID" value="AYE35897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35897">
        <property type="protein sequence ID" value="AYE35897"/>
        <property type="gene ID" value="CP523_15800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Plasmid unnamed1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cauli_VI" evidence="1">
        <location>
            <begin position="9"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="75" mass="8633" checksum="9871CB0770BCE398" modified="2018-12-05" version="1">MSKKKAKSKFYAIKEGNGVSNLIVNTWGECSKLVLGYNSVYKSFKTREEAEDYLGYTKGLEKKIVKTKDVKKYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK83</accession>
    <name>A0A386PK83_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678780.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35694">
        <property type="protein sequence ID" value="AYE35694"/>
        <property type="gene ID" value="CP523_15340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014918">
        <property type="entry name" value="Phage_tail_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08813">
        <property type="entry name" value="Phage_tail_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="135" mass="14844" checksum="B5793CBC260B5870" modified="2018-12-05" version="1">MLANGITLSYKTKGEVYTKLTGLKEVPEMGNDPEKVENTTLEDTTKQYEYGIGDYGDLAYKFKYENKTVASPYRVLRKLADDKTVVDFEQAYPDGTKFKFKAQCSVKLGGGGVNSAMEFTLSLALQSGIAVTDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK87</accession>
    <name>A0A386PK87_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PG_binding_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12180</name>
        <name evidence="4" type="ORF">EI377_07000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673560.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35112">
        <property type="protein sequence ID" value="AYE35112"/>
        <property type="gene ID" value="CP523_12180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60503">
        <property type="protein sequence ID" value="QAS60503"/>
        <property type="gene ID" value="EI377_07000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="2">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="437" mass="48243" checksum="9E2AA14AE08CF860" modified="2018-12-05" version="1">MDSNQSNTNLEKNVVLSEKNYMSLLKSKYFLSGIAIVIILVGSLTYIGVRNNNLINSFADKVYPGAYILDKDVSGQTAEELHNTLTSMMDVEGNRQIDITVGDESFQTFYKDLEVTTPYEELEKEILNYGKDKGFFQKSKLLKNPERRDYKLELSYNEDKLKDFVNKISSSVNVEPKNAQIDINNGIHIVDGANGSKLDSQTLLETLKANIKDIDSNDTIELTGEMNTVEPSVKADALKGVNKKVSTFSTNYPGGPSGTNLEIAARNIDNSLVMPGETFSCESAIGPTTPENGFVMANTYVAGKVVKNYGGGVCQVASTLYNTMLRAGIIPTERMNHMMTVSYVPIGLDATLADGSIDLKFRNDTEFPIVINSHAGNGTLTIEFWSNDSITNGINYEPKSYPKGPLSAETYLYGYDANGNQVYEKFIDKSTYQPFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKK9</accession>
    <name>A0A386PKK9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14245</name>
        <name evidence="3" type="ORF">EI377_09150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678487.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00273"/>
    <dbReference type="EnsemblBacteria" id="AYE35498">
        <property type="protein sequence ID" value="AYE35498"/>
        <property type="gene ID" value="CP523_14245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60884">
        <property type="protein sequence ID" value="QAS60884"/>
        <property type="gene ID" value="EI377_09150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="27332" checksum="E0D16829E3F7BFEC" modified="2018-12-05" version="1">MNYSVDLHTHTIISGHAYSTLLENVNFCTKKGIKILGTSEHGPAMPGAPHIWYFHNLRVLPRTINDVIILKGCEANIIDSNGNLDIKTTSSAQLDYLIASLHEACFPPKSKEENTNAVLKVMDNYKEIEILGHLGNPNYELDYKKILKKALEKDIMIEINNSSLLGKSRKGSDIICKEIALLCKKYGNKIILSSDAHFGSLIGNFDLAIKMLNSIDMPNDQIMNNPDKLIRHLKNKGRLLDLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKS1</accession>
    <name>A0A386PKS1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10930</name>
        <name evidence="3" type="ORF">EI377_05725</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02520"/>
    <dbReference type="EnsemblBacteria" id="AYE34879">
        <property type="protein sequence ID" value="AYE34879"/>
        <property type="gene ID" value="CP523_10930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60274">
        <property type="protein sequence ID" value="QAS60274"/>
        <property type="gene ID" value="EI377_05725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="310" mass="36052" checksum="58288605276534A8" modified="2018-12-05" version="1">MENKQLVSVVMSTYNEPKEWVQLSIESILDQSYDNIEVIIVCDNPNNKEIIELLKKFEEDFRVRVLYNEKNIGLTNSLNKALKFVNGEFVARMDSDDISEKDRLLKQYNYLTENNLDLIGGGVICINENEEKISIINNLPKNSELVRKRIIKNSCVPHPTWFGKKSVFHDLNGYRAVNYAEDYDFLLRALAKGFKLGNIDEIVLKYRIRSSSISNSNGLKQFITSQMLINLYKKDKILEDINVINEFIGEELKKIDKSEEINYYEASREFTKGCIGIKKLDFNQGLKIIKGLTKSKYYRKKIWGYIRALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKS5</accession>
    <name>A0A386PKS5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NERD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13615</name>
        <name evidence="3" type="ORF">EI377_08510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679023.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35382">
        <property type="protein sequence ID" value="AYE35382"/>
        <property type="gene ID" value="CP523_13615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60772">
        <property type="protein sequence ID" value="QAS60772"/>
        <property type="gene ID" value="EI377_08510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="97" mass="11425" checksum="D6A8EB187085B40D" modified="2018-12-05" version="1">MDWKVIGLENDEKWIQEIDGNTYYRVNPCTQNDAHIKYLRRYLGVDRPIYYSIVVFGEESILVNKDKYGGYNSVMNLGELEDEMVLLTNSELLFSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKX8</accession>
    <name>A0A386PKX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15195</name>
        <name evidence="3" type="ORF">EI377_10150</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678582.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03133"/>
    <dbReference type="EnsemblBacteria" id="AYE35668">
        <property type="protein sequence ID" value="AYE35668"/>
        <property type="gene ID" value="CP523_15195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61055">
        <property type="protein sequence ID" value="QAS61055"/>
        <property type="gene ID" value="EI377_10150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="63"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="330" mass="37548" checksum="F46FD3584A1B7091" modified="2018-12-05" version="1">MFKEAMDCIDAGSEYCPCHLAESGECILCSQLHGSCFCDCSNWKGVCIYQEFKYNGLKAKEGRKTYKCLVKERILHQPDVLLIKFEAPHKLAIDLVKPGSFVFIRTDENVYFDVPISILESDIESNIISIMIEIRGIKTKKLLDINIGEEITIRGPYWNGVFGVKNIQKQKEKNVLVMARGIGMAPMMPVIRKLSENNNKINLILDREPYDNIYVEEFLKKYNITLIEINLVDKGELSTEGKTALKSFVNNENITHVHVAGADILTYKVIDYLDEIDRKDVTLSCCNNTKMCCGEGVCGSCTTRFKGHKVKRFCKVQADPRDVFEGRRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL43</accession>
    <name>A0A386PL43_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF368 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14610</name>
        <name evidence="3" type="ORF">EI377_09580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678660.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35562">
        <property type="protein sequence ID" value="AYE35562"/>
        <property type="gene ID" value="CP523_14610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60949">
        <property type="protein sequence ID" value="QAS60949"/>
        <property type="gene ID" value="EI377_09580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="28787" checksum="94EC5FEF7C8FC50F" modified="2018-12-05" version="1">MKNLINMLKGMAIGISNIIPGVSGGTMAVVLGIYDKIISSVINFFKDWKKNGLFLAELAIGAAIGILAFSNLITFLLDNYPSQTNLFFIGLILGSAPLIFKKATESQVNKSNYVWFVIAFVLLAIMGIVGEAEGAIKVVSELSIGTIIILLIAGFVAAATMILPGVSGSFILIMIGMYYPIVNAVKEFNIPVLIVVAVGVLLGFITMTKVIETLFNKYPQTVYFIILGLILGSIFGIYSGIGNGFMILVSISDFIIGFLISYMLGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLB3</accession>
    <name>A0A386PLB3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12520</name>
        <name evidence="3" type="ORF">EI377_07405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675299.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02009"/>
    <dbReference type="EnsemblBacteria" id="AYE35179">
        <property type="protein sequence ID" value="AYE35179"/>
        <property type="gene ID" value="CP523_12520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60582">
        <property type="protein sequence ID" value="QAS60582"/>
        <property type="gene ID" value="EI377_07405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="103" mass="11922" checksum="FD29794DD138B097" modified="2018-12-05" version="1">MNRDKNLPLTETTYYILLALLEPAHGYVIMQKVEKLSNEQVRLAPGTLYGAIENLLKLDFIKPIPNDDKRRKVYVITELGKEILKLDMERMTHIIEVTANLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLD8</accession>
    <name>A0A386PLD8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35682">
        <property type="protein sequence ID" value="AYE35682"/>
        <property type="gene ID" value="CP523_15280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018925">
        <property type="entry name" value="Phage_terminase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10668">
        <property type="entry name" value="Phage_terminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="240" mass="27457" checksum="08F859BE3F5A24B7" modified="2018-12-05" version="1">MGKSRSPNRDKAFKIYRDSDGTILIKDIATTLNEKVSNIYAWKRNDNWDKKLKRGAPKGNKNAIGNKGGAPKGNLNALKHGEYCDSSKFLDKGFLQKYIPAATKNIIKGAVDENISAVDILWCNIMFLYASIVRAQKIMYVKNHDDLTKELKKQSWGKTGLEEYELQFAWDKQERFIKAQASAMNTLNKMINDYEVLIHKNWDLATEEQKTRIEVLKNKISQNDYNSTTEGIQVVDDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLL7</accession>
    <name>A0A386PLL7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678534.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35686">
        <property type="protein sequence ID" value="AYE35686"/>
        <property type="gene ID" value="CP523_15300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="115" mass="13809" checksum="6B793A974A83E5DD" modified="2018-12-05" version="1">MELEYLEEIKDDFINTYDVHLKDSGLNPLVNWFIHENDLYMTDEYPVENACHYLAIGAYLIYKNKIEELNNKILEKIKESYNLINSGIYDENFTEEDKVYIKQDIKKIEESKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLP4</accession>
    <name>A0A386PLP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07225</name>
        <name evidence="2" type="ORF">EI377_01980</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673885.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35842">
        <property type="protein sequence ID" value="AYE35842"/>
        <property type="gene ID" value="CP523_07225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62151">
        <property type="protein sequence ID" value="QAS62151"/>
        <property type="gene ID" value="EI377_01980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="158" mass="17802" checksum="5210941769788081" modified="2018-12-05" version="1">MKSIEFQFDERADGDDVPVSIDPTNPTQMLEVAFKKVCPGDIVWLSGVVVLDHEYEQDLEDEEEEDKREEESANITIIIQKTSSLIDTPKPIYTLEVDLAPASDDVAIPFSHVDVETTELSNVRYKVLVYSDEENPEDVDIEGPNTLTAIRFIKGNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLS9</accession>
    <name>A0A386PLS9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00015</name>
        <name evidence="6" type="ORF">CP523_01700</name>
        <name evidence="7" type="ORF">CP523_11035</name>
        <name evidence="8" type="ORF">CP523_15715</name>
        <name evidence="9" type="ORF">EI377_12220</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32945">
        <property type="protein sequence ID" value="AYE32945"/>
        <property type="gene ID" value="CP523_00015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33264">
        <property type="protein sequence ID" value="AYE33264"/>
        <property type="gene ID" value="CP523_01700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34900">
        <property type="protein sequence ID" value="AYE34900"/>
        <property type="gene ID" value="CP523_11035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35766">
        <property type="protein sequence ID" value="AYE35766"/>
        <property type="gene ID" value="CP523_15715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61435">
        <property type="protein sequence ID" value="QAS61435"/>
        <property type="gene ID" value="EI377_12220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00015"/>
    <dbReference type="KEGG" id="csep:CP523_01700"/>
    <dbReference type="KEGG" id="csep:CP523_11035"/>
    <dbReference type="KEGG" id="csep:CP523_15715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="38761" checksum="02739165C8673A8A" modified="2018-12-05" version="1">MSKTNIKCPRCNSDKLYKFGMNKQAKQKYQCKQCKRQFVLGDGDGRPKLNNPKCPRCGKGTYLHHAYKHYNRYKCNNKKCNHIIVKHHTTNIDTASSELVSGSLSMKGMRFPLHVILTALTLYFLNNSSTRAISQFLMINSGIKVSHVTIASWTNKFAPFFKQKADKFKASLNLQSDDWHADETVVFINGERYYLWLAIDSETRFILAFHLTKSRSSDSAYALVNEAKKFGEPANFITDRLPSYNEAVATLLPNTTHIPVAPMSSDTNNNLIESFNKTFKAWYKTKKGFNSFQKANNLIYLFIFHYNFIRPHGSLNNCTPAEVAGFASDSFSKNSWFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAM9</accession>
    <name>A0A386PAM9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine gamma-lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00165</name>
        <name evidence="3" type="ORF">EI377_10730</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677396.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01199"/>
    <dbReference type="EnsemblBacteria" id="AYE32975">
        <property type="protein sequence ID" value="AYE32975"/>
        <property type="gene ID" value="CP523_00165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61157">
        <property type="protein sequence ID" value="QAS61157"/>
        <property type="gene ID" value="EI377_10730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009651">
        <property type="entry name" value="Met_g_lyase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46658">
        <property type="entry name" value="PTHR46658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06838">
        <property type="entry name" value="Met_gamma_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="425" mass="46851" checksum="3DDB06082E70BC07" modified="2018-12-05" version="1">MLNLTEELMKKTYNFKKETLDLYEKALKEVENEFKIYDEIREYNQLKVLTAFQEERISESHFTNSSGYGYDDIGRDSLDKVYARVFNTESALVRPHFVNGTHAIGCALMGNLRTGDTMLAISGAPYDTLHNIIGISGKENIGSLKEYGVNYKQIDLKDGKFDLAKIKEALNSDKSIKLVHIQRSTGYGWRNSFLVSEIGEVIKFVKELREDVVVFVDNCYGELIDTIEPTDVGADLIAGSLIKNIGGGIAPTGGYIAGKTKYVEQAAFRLTTPGIGGECGSTFGVMRQLYQGLFLAPHVAIEAVKGAIFCAKIMELAGFEVLPKPTDKRSDIIQAIKFGNKENLINFCKGIQKGSPIDSFVECEPWAMPGYTDEVIMAAGAFIQGSSIELSADAPIREPYIAYLQGGLTFDHVKIGVLIALNKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAN9</accession>
    <name>A0A386PAN9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32993">
        <property type="protein sequence ID" value="AYE32993"/>
        <property type="gene ID" value="CP523_00265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="122" mass="14755" checksum="C0C94CF69DA1E880" modified="2018-12-05" version="1">MKFININKPVCKFKFEKDLIFKSSLQKKIYLALKDLSYLMEINVQLDEYILPIVILDKFSKEPILVIEVDDMIYSKNYNIFKDDIYIHKYLDFLDLKFIRVWSNDWLKDKNTVINNIYSNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB80</accession>
    <name>A0A386PB80_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01275</name>
        <name evidence="3" type="ORF">EI377_11775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675548.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33183">
        <property type="protein sequence ID" value="AYE33183"/>
        <property type="gene ID" value="CP523_01275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61353">
        <property type="protein sequence ID" value="QAS61353"/>
        <property type="gene ID" value="EI377_11775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="15480" checksum="211CCBBCE683CE5B" modified="2018-12-05" version="1">MATYVFVIIGVLIILVGGITALSKKRLYKYGVKNKGIVVDLDTYTYITPGPDFNTIYHSGIISIIEVEDNNKKFKVAYCKIEENLPLEIGDKVDVIYYKGDIENLEIYKYKGRYVLSMTIASVGVIIIILSSIFHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBE3</accession>
    <name>A0A386PBE3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_01590</name>
        <name evidence="10" type="ORF">EI377_12110</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00871"/>
    <dbReference type="EnsemblBacteria" id="AYE33245">
        <property type="protein sequence ID" value="AYE33245"/>
        <property type="gene ID" value="CP523_01590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61417">
        <property type="protein sequence ID" value="QAS61417"/>
        <property type="gene ID" value="EI377_12110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01590"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="29"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="36058" checksum="4E5D733FD1A4F472" modified="2018-12-05" version="1">MLKNIIVISKSTDPYCNLAMEEYIFNNIKKNEVIFYLWQNHKTVVIGRNQNPYIECDVDYIEGNGAKIARRMSGGGTVYHDLGNLNFTFVTSKENHNIEKQILVIRKAIEKFGLSVDKSGRNDLTINNKKFSGHAFYEDDNKMFHHGTIMIDVDKLELNNILKPSKIKLKSKGIDSVKSRVINLKECNNDITLNDVFKNLIESFKEVYGEVYSIRETIGKEVKGNLLEKYKNHKWVYGESPEFNVNLETPTDIGNIQILMDIKDNVVKKVRVYSDSLNQISFSDLEQLIVKQEFNRENILKTVYYFLESFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBM8</accession>
    <name>A0A386PBM8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cmk</name>
        <name evidence="10" type="ORF">CP523_00075</name>
        <name evidence="11" type="ORF">EI377_10555</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678948.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00298"/>
    <dbReference type="EnsemblBacteria" id="AYE32957">
        <property type="protein sequence ID" value="AYE32957"/>
        <property type="gene ID" value="CP523_00075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61129">
        <property type="protein sequence ID" value="QAS61129"/>
        <property type="gene ID" value="EI377_10555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="24205" checksum="0FC7B364940080F9" modified="2018-12-05" version="1">MKISVAIDGPAGAGKSTIAKLVGKNLDLMYINTGAMYRAVALKAKENNLDINNVEEICNIIDSMEMKFENDDLILNGENIQSKITMPEISSVVSAYASIQEVRHKLVSLQRKMSEKFDVIMDGRDIGTVVLKEAPYKFFLTATPEERADRRYKELKDRGLVVNYNEILNDIIKRDYLDTHREVDPLRKADDAIEIDTTGLTIEEVTEKINSYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBN6</accession>
    <name>A0A386PBN6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0297 protein CP523_01155</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0297 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674411.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02287"/>
    <dbReference type="EnsemblBacteria" id="AYE33160">
        <property type="protein sequence ID" value="AYE33160"/>
        <property type="gene ID" value="CP523_01155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01507">
        <property type="entry name" value="UPF0297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009309">
        <property type="entry name" value="IreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40067">
        <property type="entry name" value="PTHR40067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06135">
        <property type="entry name" value="IreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037258">
        <property type="entry name" value="DUF965_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="85" mass="9811" checksum="579D91D04DF1C130" modified="2018-12-05" version="1">MSNNLDHTMQFNLNINKEDLTKSILTDVYNALKEKGYNPINQLVGYLISGDPSYITSYNGARALLRKLERDEILEEVIKCYLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBY1</accession>
    <name>A0A386PBY1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01735</name>
        <name evidence="3" type="ORF">EI377_12255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677341.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33270">
        <property type="protein sequence ID" value="AYE33270"/>
        <property type="gene ID" value="CP523_01735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61441">
        <property type="protein sequence ID" value="QAS61441"/>
        <property type="gene ID" value="EI377_12255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="19326" checksum="C69686643FCE8ED0" modified="2018-12-05" version="1">MSFDNYCHHHHDHKPNKCFIPPKIQIPRQSGPMGPKGPKGDKGDPGIPGIPGGLLGFADFYNTTEQKLDHNKPIAFANKGISGGKPIVPNAAYTIFTLQKNAKYLVLFQISANGNTSIGLALNGTLIPSSVVTDTGNTDTIGFSIIETTATNYTLSVINNNNSNLNVKDEPSHLIFLQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC05</accession>
    <name>A0A386PC05_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02835</name>
        <name evidence="7" type="ORF">EI377_13360</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676998.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00973"/>
    <dbReference type="EnsemblBacteria" id="AYE33475">
        <property type="protein sequence ID" value="AYE33475"/>
        <property type="gene ID" value="CP523_02835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61646">
        <property type="protein sequence ID" value="QAS61646"/>
        <property type="gene ID" value="EI377_13360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="5">
        <location>
            <begin position="437"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="649" mass="73208" checksum="9E876A03514574E5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCH4</accession>
    <name>A0A386PCH4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03815</name>
        <name evidence="9" type="ORF">EI377_14350</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675480.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01535"/>
    <dbReference type="EnsemblBacteria" id="AYE33655">
        <property type="protein sequence ID" value="AYE33655"/>
        <property type="gene ID" value="CP523_03815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61817">
        <property type="protein sequence ID" value="QAS61817"/>
        <property type="gene ID" value="EI377_14350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362690" evidence="6">
        <location>
            <begin position="28"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="813"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="7">
        <location>
            <begin position="42"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="842" mass="91695" checksum="FF7704794C3642F9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCJ3</accession>
    <name>A0A386PCJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tryptophan transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679186.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00027"/>
    <dbReference type="EnsemblBacteria" id="AYE33500">
        <property type="protein sequence ID" value="AYE33500"/>
        <property type="gene ID" value="CP523_02975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031360">
        <property type="entry name" value="TrpP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17099">
        <property type="entry name" value="TrpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="177" mass="19301" checksum="347C0AD4C831B0E5" modified="2018-12-05" version="1">MNRNENVKKMILNSILIAIGALLHQITPVLGLPMQPDFAIAILFIIIISNKDYKTTLISSIIIGIFTALTTKFPGGQLPNIIDKVLTANIIYFILLPLRNRVSDNVKMILSLIFGTVLSGLIFLYSAQLIVGLPGEFMNLVKVVVIPAAIMNAILGSILYKAITIAFKATGMNFSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCM9</accession>
    <name>A0A386PCM9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">hemL</name>
        <name evidence="9" type="ORF">CP523_03185</name>
        <name evidence="10" type="ORF">EI377_13700</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677262.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02146"/>
    <dbReference type="EnsemblBacteria" id="AYE33540">
        <property type="protein sequence ID" value="AYE33540"/>
        <property type="gene ID" value="CP523_03185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61703">
        <property type="protein sequence ID" value="QAS61703"/>
        <property type="gene ID" value="EI377_13700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03185"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="424" mass="47037" checksum="A86DD7F2BF232B3D" modified="2018-12-05" version="1">MRNQVIFHESKKFMPGGVNSPVRAYRDMNIDPPIIRSGKGAIIKDEEGKEYIDFVLAWGPMILGHCDEDVVTSIKEISEHAIAFGAPTELELIMAKFLCDNLKNIEMVRMVNSGTEATMSAIKLARGYTKKNKIVKFAGCYHGHFDGFLVEAGSGVLTEGIPGCLGVPQDSIKNTLIGVYNDLEQVKSLFQEYGNDIAGIIIEPVAGNMGVIKAEDNFMIGLRELCDKYGALLIFDEVMSGFRVDFEGAQSLFDVKPDLVTYAKIIGGGLPCGAYGGKKEIMECLSPVGGVYQAGTMSGNPVVMAAGIATLNKIKENKEKYYNHINKLGDKLEKGMLAIAKEKNIPMVINRQGGMLTIFFNNLKEIKTYDDVKKCNSDIFKKYFLHMINKGFNIPPSQYEALFLCTEHNEEHINKFLQAFREFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCX8</accession>
    <name>A0A386PCX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04780</name>
        <name evidence="3" type="ORF">CP523_15815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>unnamed1</name>
    </geneLocation>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
            <plasmid evidence="3">unnamed1</plasmid>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
            <plasmid evidence="4">unnamed1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023672">
        <property type="protein sequence ID" value="AYE35900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33835">
        <property type="protein sequence ID" value="AYE33835"/>
        <property type="gene ID" value="CP523_04780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35900">
        <property type="protein sequence ID" value="AYE35900"/>
        <property type="gene ID" value="CP523_15815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04780"/>
    <dbReference type="KEGG" id="csep:CP523_15815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Plasmid unnamed1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="410" mass="47954" checksum="D287B55E4C4F8F11" modified="2018-12-05" version="1">MKLQRIIKIKCYESLIFISIFLLTIVSNSIYEAVSLQKNLNSQHIDTGFIQLKDNYDGFKGRLSIIEFFNEPNSLDKMKKLYIDIANDNNLKYYEILKQPLTYIGEYKGNPICTKGEEFINKEVDGKLMTTVNSLQIGYKTSNYLNMKDKIECGEYFSGDDYLLDESKAVPVVLGYSYLENYNIGDYIQCDYLFLNLKLKVIGFLKKDSKFSIEYENFLDDKIIMPSLNIESDNFSDSKFTKILYSLKNTGYIPYDNDSEYNYITTTVDNIVDKLDIDWTYRGRVENPFKENPVNISVKASKIIKISSWILSLILLILIFILEKKRCDFEDFSLNKRDRLIMKTKIFGGTLLQIILLYIITCFILWVCFRSNVIYFTLKNIQIRVFPIMLLGFIIIVYINNLHIEKSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD10</accession>
    <name>A0A386PD10_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalt transport protein CbiN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Energy-coupling factor transporter probable substrate-capture protein CbiN</fullName>
            <shortName evidence="10">ECF transporter S component CbiN</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cbiN</name>
        <name evidence="12" type="ORF">CP523_01435</name>
        <name evidence="13" type="ORF">EI377_11955</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CbiN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675605.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00839"/>
    <dbReference type="EnsemblBacteria" id="AYE33214">
        <property type="protein sequence ID" value="AYE33214"/>
        <property type="gene ID" value="CP523_01435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61386">
        <property type="protein sequence ID" value="QAS61386"/>
        <property type="gene ID" value="EI377_11955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01435"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00330">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003705">
        <property type="entry name" value="CbiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38662">
        <property type="entry name" value="PTHR38662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02553">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01165">
        <property type="entry name" value="cbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 10" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362692" description="Cobalt transport protein CbiN" evidence="11">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="93" mass="10313" checksum="D7861C3486FC5DD0" modified="2018-12-05" version="1">MKKKNLILFVICILLIVGPFIISRNGEFAGADEQAEGLITEINSDYEPWFESLWEPPSGEVESFLFSMQAAIGAGFIGYFVGKKKYDTGNKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDB1</accession>
    <name>A0A386PDB1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05620</name>
        <name evidence="2" type="ORF">EI377_16135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33983">
        <property type="protein sequence ID" value="AYE33983"/>
        <property type="gene ID" value="CP523_05620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62125">
        <property type="protein sequence ID" value="QAS62125"/>
        <property type="gene ID" value="EI377_16135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="15642" checksum="B4F32291295F49D2" modified="2018-12-05" version="1">MGYLPEIANKIKNGERVERIVDSIRGSKGVGNRNKFNFSNEKKFDKHFDKHVIKQGEFGNITKDDYLKLANEFIDSSGKNVLSRTASNGDILKFNNKTNEFSIVTKEGVIRTYHKLNPQIHGKGTNLDYWNGPDCNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDH4</accession>
    <name>A0A386PDH4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pnp</name>
        <name evidence="9" type="ORF">CP523_00640</name>
        <name evidence="10" type="ORF">EI377_11130</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676364.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00659"/>
    <dbReference type="EnsemblBacteria" id="AYE33061">
        <property type="protein sequence ID" value="AYE33061"/>
        <property type="gene ID" value="CP523_00640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61230">
        <property type="protein sequence ID" value="QAS61230"/>
        <property type="gene ID" value="EI377_11130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="621"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="703" mass="77488" checksum="02CD67CEF3573E1E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDJ4</accession>
    <name>A0A386PDJ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic sulfite reductase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">asrB</name>
        <name evidence="3" type="ORF">CP523_03220</name>
        <name evidence="4" type="ORF">EI377_13735</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02139"/>
    <dbReference type="EnsemblBacteria" id="AYE33547">
        <property type="protein sequence ID" value="AYE33547"/>
        <property type="gene ID" value="CP523_03220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61710">
        <property type="protein sequence ID" value="QAS61710"/>
        <property type="gene ID" value="EI377_13735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014260">
        <property type="entry name" value="Sulphite_reductase_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02911">
        <property type="entry name" value="sulfite_red_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="29579" checksum="D078BF62947DAD52" modified="2018-12-05" version="1">MSKNVYTPFISEILEVIKHTEIEYTFRMSFTGDVKPGQFFEVSLPKFGEAPISVSGIGENYVDLTIRKVGKVTNEVFKNYAGDKLFLRGPYGNGFDIENYKGNEVIVVAGGTGLSPVKGIVDYFSKNPNDANGFTLISGFKSPKDILFKKDMEEWNKNMNFILTVDSAEEGYEGNVGLVTKYVSELKIKDMNNVQVIVVGPPMMMKFTVLEFLKLGIDENNIWISQERKMCCGLGKCGHCRIDDTYICLDGPVFNYSKGKQLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDP6</accession>
    <name>A0A386PDP6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06440</name>
        <name evidence="7" type="ORF">EI377_00920</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677426.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02165"/>
    <dbReference type="EnsemblBacteria" id="AYE34135">
        <property type="protein sequence ID" value="AYE34135"/>
        <property type="gene ID" value="CP523_06440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59503">
        <property type="protein sequence ID" value="QAS59503"/>
        <property type="gene ID" value="EI377_00920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="25612" checksum="912DCBB9653C3029" modified="2018-12-05" version="1">MKKVMIIEDDPMVALINRKYVESIKGFLVEDVVSEKDKAIKILKSKSIDLILLDVYLPKENGIEILKAIRAEGILVDVIMITATNKVEKIKCAFAYGVVDYLIKPFEFDRFQEAINKFLAKDNLLKECTGIKQKQIDNLSKVEITLDLPKGLNEKTLKKLTDFLEENIGTIWTIREIASELGISNVTIKKYMEYLEEVGKVSSTITYGNIGRPEYKYEYKNSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDY2</accession>
    <name>A0A386PDY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679069.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00073"/>
    <dbReference type="EnsemblBacteria" id="AYE34000">
        <property type="protein sequence ID" value="AYE34000"/>
        <property type="gene ID" value="CP523_05720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="109"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="291" mass="33321" checksum="EDD1CC3E12393108" modified="2018-12-05" version="1">MCQLIEDFKISLIEDGKSAKTIESYVGDIKAFIEFLGDKGVEFNGTLQRFYVVSYKNFLVESNYEVATINKKINSIHALNRYLVAIGAMKEIVVENSKDRVKIAYGSEKQVEVYSDKEVERILFYIQNEEKVSKRNKVIVMLLLYTGVRVSELCSIKIKDIDFLNYSIKIYGKGGKFREVPMKFDLADVIKEYIKDRDYSVKDSEYLVIGQRGALKRDAINTMLERLTKDIGMVNKLKPHTFRHTFCTRLINRGVPISTVSKLAGHSSVDTTATFYVNSSREEKLKAVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE00</accession>
    <name>A0A386PE00_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01630</name>
        <name evidence="3" type="ORF">EI377_12160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675687.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33251">
        <property type="protein sequence ID" value="AYE33251"/>
        <property type="gene ID" value="CP523_01630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61424">
        <property type="protein sequence ID" value="QAS61424"/>
        <property type="gene ID" value="EI377_12160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="94" mass="10919" checksum="AA26E7C6AF2BA170" modified="2018-12-05" version="1">MYSFILEVLFIMVPLAISLIIYMKIDKKYAITNIISLKLGIKREWMAFFCFCFTILIMLTINMINEYVINILPIVYFILGGIFTGMVVGVKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE15</accession>
    <name>A0A386PE15_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aquaporin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Aquaporin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05935</name>
        <name evidence="9" type="ORF">EI377_00420</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01890"/>
    <dbReference type="EnsemblBacteria" id="AYE34040">
        <property type="protein sequence ID" value="AYE34040"/>
        <property type="gene ID" value="CP523_05935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59412">
        <property type="protein sequence ID" value="QAS59412"/>
        <property type="gene ID" value="EI377_00420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="24840" checksum="E16199AFE1B56629" modified="2018-12-05" version="1">MMSFLAELIGTMILVYLGDAVVANVVLKKTKGNNSGWIVITTGWAFAVAIPALIFGATSGAHFNPALTIALAAIGKFAWCEVPMYLLAQMLGGFIGAVLVFIQYYNHFEETEDKDGKLGVFCTGPAIRNGKFNFISEFIATALLVFGILGLGQVDMANGLNTIAVGLLIWALGLSSGGTTGYAMNPARDLAPRIAHAILPVPGKRDSDWKYAWIPVIAPIVGGLIGALAFTWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE35</accession>
    <name>A0A386PE35_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Meso-diaminopimelate D-dehydrogenase</fullName>
            <shortName evidence="10">DAPDH</shortName>
            <shortName evidence="10">Meso-DAP dehydrogenase</shortName>
            <ecNumber evidence="5 10">1.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_01845</name>
        <name evidence="14" type="ORF">EI377_12365</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13561"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58556"/>
            <dbReference type="EC" id="1.4.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the diaminopimelate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.16" evidence="5 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677286.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02382"/>
    <dbReference type="EnsemblBacteria" id="AYE33291">
        <property type="protein sequence ID" value="AYE33291"/>
        <property type="gene ID" value="CP523_01845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61462">
        <property type="protein sequence ID" value="QAS61462"/>
        <property type="gene ID" value="EI377_12365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01845"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047850">
        <property type="term" value="F:diaminopimelate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010190">
        <property type="entry name" value="Diaminopimelate_DH_Ddh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032094">
        <property type="entry name" value="Meso-DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16654">
        <property type="entry name" value="DAPDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025648">
        <property type="entry name" value="DDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01921">
        <property type="entry name" value="DAP-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAPDH_C" evidence="12">
        <location>
            <begin position="122"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR025648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR025648-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="326" mass="36084" checksum="6DF6D0BCF38FE248" modified="2018-12-05" version="1">MSNKIRIGVVGYGNLGKGVEMAVAQNDDFELVKIFTRRDVQKVKTFGAEVDSINNIQEYKGLIDVMILCGGSATDLRIQGPMVAEMFNTVDSFDNHPKIPEHFEKMDEVAKAAKNLSVISVGWDPGLFSLNRLIGQVALPEGTDYTFWGTGVSQGHSDAIRRIEGVKNGIQYTIPVESALEKVRLGQHPELTAREKHTRVCYVVAEEGADLDKIENEIKNMPSYFADYDTTVNFISEDELEKNHKGMPHGGFVIRTGTTGDGTKQRVEFSLDLGSNPEFTSSILIAYARAAYRLSKEGKTGALTVLDIPFGYLSAKNREELRKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE78</accession>
    <name>A0A386PE78_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ade</name>
        <name evidence="8" type="ORF">CP523_03260</name>
        <name evidence="9" type="ORF">EI377_13775</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677232.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02132"/>
    <dbReference type="EnsemblBacteria" id="AYE33554">
        <property type="protein sequence ID" value="AYE33554"/>
        <property type="gene ID" value="CP523_03260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61717">
        <property type="protein sequence ID" value="QAS61717"/>
        <property type="gene ID" value="EI377_13775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="66"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="417"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="578" mass="64019" checksum="07628CD6D104A7AB" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC3</accession>
    <name>A0A386PEC3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein CotJB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00335</name>
        <name evidence="3" type="ORF">EI377_10825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678130.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00577"/>
    <dbReference type="EnsemblBacteria" id="AYE33006">
        <property type="protein sequence ID" value="AYE33006"/>
        <property type="gene ID" value="CP523_00335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61174">
        <property type="protein sequence ID" value="QAS61174"/>
        <property type="gene ID" value="EI377_10825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024207">
        <property type="entry name" value="CotJB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12652">
        <property type="entry name" value="CotJB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="CotJB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="82" mass="9649" checksum="140F1B90F9DA659B" modified="2018-12-05" version="1">MSENSLLVNIMKYIFYAIDLNLYLDNFPTNQKAIDDYKSVSEKLDFLIVQYERCYGPLSNFGSASIEDPVKWTCNPWPWENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEF5</accession>
    <name>A0A386PEF5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="12" type="ORF">CP523_06780</name>
        <name evidence="13" type="ORF">EI377_01255</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678995.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01459"/>
    <dbReference type="EnsemblBacteria" id="AYE34190">
        <property type="protein sequence ID" value="AYE34190"/>
        <property type="gene ID" value="CP523_06780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59554">
        <property type="protein sequence ID" value="QAS59554"/>
        <property type="gene ID" value="EI377_01255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06780"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="44782" checksum="BF5A275B39EC3DA5" modified="2018-12-05" version="1">MGRKEIVAMILAGGQGSRLGVLTKQLAKPAVPFGGKYRIIDFPLSNCSNSGIYTVGVLTQYRPLELNSHIGIGDPWDLDRRDGGVSILPPYQEEKGGMWYKGTANAIYQNIEYVDRYNPEYILILSGDHIYKMDYDKMLDFHKKNNADSTIAVIDVPIKEASRFGIMNTREDFSIYEFEEKPKKPKSTNASMGIYIFKWDVLKKYLIEDELDKDSSNDFGKNIIPRMLNDGRKMMAYPFKGYWKDVGTIDSLWEANMDLLKLDNRLGLYNNDWKIYSRNPVSPAQYIGEKARAKESLIAEGCILNGTVENSILSQGVHVGENTIIRDSVIMPNVKIGNNVIIEKAIIGNDVIIGDGNKIGNGKEISVIAAGEMMPCKTEVAIDSLDIKSIEEKVKEYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI7</accession>
    <name>A0A386PEI7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enolase</fullName>
            <ecNumber evidence="9">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eno</name>
        <name evidence="14" type="ORF">CP523_03860</name>
        <name evidence="15" type="ORF">EI377_14395</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
        <text evidence="9">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675500.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01544"/>
    <dbReference type="EnsemblBacteria" id="AYE33664">
        <property type="protein sequence ID" value="AYE33664"/>
        <property type="gene ID" value="CP523_03860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61826">
        <property type="protein sequence ID" value="QAS61826"/>
        <property type="gene ID" value="EI377_14395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03860"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="Enolase-like_N"/>
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        <property type="entry name" value="Enolase_C"/>
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        <property type="entry name" value="Enolase_CS"/>
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            <end position="137"/>
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            <end position="370"/>
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        <ligand>
            <name>substrate</name>
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        </source>
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            <dbReference type="SMART" id="SM01193"/>
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        <source>
            <dbReference type="EMBL" id="AYE33664.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS61826.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="431" mass="47002" checksum="D8A8CABF7B4F5D5D" modified="2018-12-05" version="1">MKDYCEIVDVVARQIIDSRCFPTVEVEVYLEDGTMGRAAVPSGASTGMYEAVELRDGDKDKFMGKGVLKAVQNVNDTIAEELIGCNVYDQTYIDKMLIELDGTNNKGKLGANAILGVSLAVANAAANSLGMPLYQYVGGVNAKVLPVPMMNIINGGSHADNSVDLQEFMVMPVGACCFSEALRMCAEVYHTLKKILNDKGYSTGIGDEGGFAPNLKSNAEAIEVILEAIEKAGYKAGEDMFIAIDAASSEYYKDGKYVLENEGKTLTAAEMVDFLEDWVNKYPIISIEDGMAEEDWEGWKLITERLGKKVQLVGDDLFVTNTERLERGIDMGVGNSILIKLNQIGTLTETLNAIEMANRAGYTAVISHRSGETEDTTIADLVVAVNAGQIKTGAPARSERVAKYNQLLRIEEELDDVAEYRGRKAFFNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEL0</accession>
    <name>A0A386PEL0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_08540</name>
        <name evidence="9" type="ORF">EI377_03290</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="AYE34473"/>
        <property type="gene ID" value="CP523_08540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59875">
        <property type="protein sequence ID" value="QAS59875"/>
        <property type="gene ID" value="EI377_03290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08540"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
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        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PG_synth_SpoVB"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="12"/>
            <end position="35"/>
        </location>
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    </feature>
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            <begin position="354"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="511" mass="55921" checksum="9F319F70716C6107" modified="2018-12-05" version="1">MKKQSLIKASLILGITGIVARFLGLFFRWPLIMLIGDEGVGYYQMSYPLYMFFVAMASGVPVAISKMISEKKAMGRIDEVFEIVKESTILMMVLGAGTTFILFFFAKPIINFLRWDMKSYYALLGISFAPLIISFMTIYRGFFQGLQNMTPTGVSQILEQVGRVVIGVGLAFILLPKGIEYSAGGAAFGAAAGGLIGGTYLYIKYRATKRQMGIKKVKTNPEILTNILKIALPISVGATVGTIMNLIDSILVPQKLLQAGLTSQQSTILYAQLTGKAAVIVNIPLTLSMALCTSLIPIIAENYILRKRKELNSKIELSLKLSSVIAMPCMLGLFFLSGPIMKLIFPGKFDGIEILRFLSISIPFVILTQTTTSILQGTGHYIRPVINLFIGCLIKVILTLILVPIPSINIYGAVIASVSAYIVATVLNLISLKTKMKSSIHFYSSFIKPTIAALVMIIGVLLTYINLITKISSEGLTCLISIFVGVCIYGIAILVFKVFDINEIKNRIVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP8</accession>
    <name>A0A386PEP8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF512 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_01025</name>
        <name evidence="5" type="ORF">EI377_11520</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674497.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02314"/>
    <dbReference type="EnsemblBacteria" id="AYE33136">
        <property type="protein sequence ID" value="AYE33136"/>
        <property type="gene ID" value="CP523_01025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61306">
        <property type="protein sequence ID" value="QAS61306"/>
        <property type="gene ID" value="EI377_11520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ_6" evidence="2">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Radical_SAM_2" evidence="3">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="DUF512" evidence="1">
        <location>
            <begin position="219"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="445" mass="50783" checksum="DA5E9116B26FFD9B" modified="2018-12-05" version="1">MKNLITKVEEGSIAEEIGIEVDDVLLAINDTPIDDIIDYKFLAADEEVVLDIQKSDGEIWAYEIEKEYGEDLGLEFGGGIMDKAKSCTNKCMFCFIDQLPKGMRETLYFKDDDSRLSFLQGNFVTLTNMKDEDIDRIIRYKISPINISVHTTNPELRVKMLKNRFAGSILERLKKLRDAEIEMHAQVVCIPNVNNGEELRKTILDLYELSPYVKNVAVVPIGITKFREGLAKVDTFDKETSKQEILMVKEMQDRFIKEIGAPFVRLSDEFYLVAGMEVPSEEFYSGYEQLEDGVGMIRYFREAVNRDLEFLNTKIKGSFSMVTGALAYDEILSAANKIKAKNSNIKIDVYKIINYFFGETITVAGLLTGKDIIEQLKGKINSEYLIMPDNMFRKGYELGPKNERIMLDDITIKDLENALNIKVIVCDYTGDNLIDIINEHSKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET3</accession>
    <name>A0A386PET3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04335</name>
        <name evidence="8" type="ORF">EI377_14870</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00411"/>
    <dbReference type="EnsemblBacteria" id="AYE33754">
        <property type="protein sequence ID" value="AYE33754"/>
        <property type="gene ID" value="CP523_04335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61911">
        <property type="protein sequence ID" value="QAS61911"/>
        <property type="gene ID" value="EI377_14870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="434" mass="48459" checksum="830AB0B5142FF682" modified="2018-12-05" version="1">MSIEGNLKVDSYINEVCSLIKNKKVHTSIREELLCHIEEITEDYISQGESYETSIDKALAKMGSAEIVGVDLNKVHKANVDWPLLLLTSAFVLFGIFILSFMDKNNILSEIYSNSLSKTIVYAAIGALLLLVILKINYRNIKKYSKHIYIGTILASILTIFFSSHINGAMGWIIIGPISFNIFNIAPFPLIIALAGIFENWDWTNKKNLLIGSILAFAPTIIFCYGHTLSNASIYFIAAITVMLISGVKLKHIILSIVPFTVLFAGFIFTEPYRVSRLLIFLNPYKYSECAGWMYTRLNSLRESAGLFGNGATFTPDMLPEFHSDFILTYIMYTFGWTTTLIIIALVLAFIIRIGFIVTNTKDIFGKILVSGFCSIFAVQFLLNILMNFSLSPIAGVGLPFISYGGSSLIINILSIGLISNVYKWRNTPLLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW3</accession>
    <name>A0A386PEW3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine transporter SstT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Na(+)/serine-threonine symporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">sstT</name>
        <name evidence="9" type="ORF">CP523_04490</name>
        <name evidence="10" type="ORF">EI377_15030</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29575"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69999"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676414.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00380"/>
    <dbReference type="EnsemblBacteria" id="AYE33784">
        <property type="protein sequence ID" value="AYE33784"/>
        <property type="gene ID" value="CP523_04490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61941">
        <property type="protein sequence ID" value="QAS61941"/>
        <property type="gene ID" value="EI377_15030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032329">
        <property type="term" value="P:serine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015826">
        <property type="term" value="P:threonine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01582">
        <property type="entry name" value="Ser_Thr_transp_SstT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023025">
        <property type="entry name" value="Ser_Thr_transp_SstT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="410" mass="43174" checksum="D6BE98621241C7A4" modified="2018-12-05" version="1">MKTIMEKWNNISLVKRIIVGLILGIVIALTIPKIGAPLSLLGSLFVGALKAIAPVLVFFLVMAALCQYKEGKKTNMKSIIVLYLLGTLAAGIIGVIGSFLFPVKLVFTSSVENLTPPSGVGEVLHNLLMSIVANPVNALANANYIGILFWAIILGLAFKNASEGSKEIILNISDAMSEVVRWIINLAPFGIMGLVYESISKQGIESLVKYGQLILVLVGCMAFFALVINPIITFIAIRKNPYPLVIKCLRDSGITAFFTRSSAANIPVNMALCKELGLNEDTYSISIPLGSTINMGGAAITISVLALAATHTLGINVDLGTTIILTILSAISACGTSGVAGGSILLVPLACSLFGIPNDVAMQVVGVGFVIGVIQDSCETALNSSTDVLYTAVAEFAKARRSKQKLVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ0</accession>
    <name>A0A386PEZ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09400</name>
        <name evidence="3" type="ORF">EI377_04145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678039.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02739"/>
    <dbReference type="EnsemblBacteria" id="AYE34625">
        <property type="protein sequence ID" value="AYE34625"/>
        <property type="gene ID" value="CP523_09400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60025">
        <property type="protein sequence ID" value="QAS60025"/>
        <property type="gene ID" value="EI377_04145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="PTHR33387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="161" mass="18536" checksum="E1ECF5457BF8D5EB" modified="2018-12-05" version="1">MESAKYYIKKLGLIPHVEGGYFKESFLSTESINQNSNEYRCLWSSIYFLLETGEVSNFHRLTSDEMWYYHAGSSLTIYMISPNGELITKNLGLNIDKGESPQVLVPKNYIFGSAMNNEGFSLVGCMVSPGFDFKDFELFERNDLLEKYPEHEDIIVKLTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF01</accession>
    <name>A0A386PF01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09475</name>
        <name evidence="2" type="ORF">EI377_04220</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679251.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34635">
        <property type="protein sequence ID" value="AYE34635"/>
        <property type="gene ID" value="CP523_09475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60034">
        <property type="protein sequence ID" value="QAS60034"/>
        <property type="gene ID" value="EI377_04220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="26641" checksum="5E03D6C1BB906C3D" modified="2018-12-05" version="1">MRHNYNSFDYWENLISENKTIRGHMFMDTPPTDKSLYIHTLIYSRNNGLNNIWSYFPDEKALLGYIQYSFLQEAFYKWIYGKDRLILKVPNISVEKIIKDAEVSKKITKEESVKMTKQLQMLKKCWDLPTGKVLPEILKFVREFNRTWYGDQTEFLYIKIFKNAEELGEFVISSSYMTSTESEFEERVSVNTEKWLEICRNAVEDKSIGEKFKDILLKSLTEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF25</accession>
    <name>A0A386PF25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03685</name>
        <name evidence="6" type="ORF">EI377_14215</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677699.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02208"/>
    <dbReference type="EnsemblBacteria" id="AYE33631">
        <property type="protein sequence ID" value="AYE33631"/>
        <property type="gene ID" value="CP523_03685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61795">
        <property type="protein sequence ID" value="QAS61795"/>
        <property type="gene ID" value="EI377_14215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="24411" checksum="E1DC6B02F6EA939C" modified="2018-12-05" version="1">MELINLKGIIREYGSGENIVHALRGVDLSINSGELIAIMGPSGSGKTTLLNILGCLDSPNLGEYILNGINITKLKQKDLASIRNSKFGFVVQSFALLDDYTIYENIKIPLDYNSNKVKNKKLKIKEILKMLSIEEKINKYPTELSGGQCQRVAIARALVNNPDIILADEPTGALDKEIGEQVMGIFKEINKSGKTVIIVTHDLNIASQCSRIINIEDGKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF60</accession>
    <name>A0A386PF60_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">tRNA uridine 5-carboxymethylaminomethyl modification protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09930</name>
        <name evidence="3" type="ORF">EI377_04715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676533.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00315"/>
    <dbReference type="EnsemblBacteria" id="AYE34695">
        <property type="protein sequence ID" value="AYE34695"/>
        <property type="gene ID" value="CP523_09930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60096">
        <property type="protein sequence ID" value="QAS60096"/>
        <property type="gene ID" value="EI377_04715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="316" mass="34705" checksum="C13DD392D6842A53" modified="2018-12-05" version="1">MLQYDLVIIGGGASGLSAGVSALKEGIKKVLILERNSDLGGNLNLFIHRGFGEYYLNKKVTGPELSTHLIKDYKALGGEFKVDSQVLKVTNEKIVTFVSPEGGVVDIKANFIILASGCREKYTGNIIVPIHKYTGIFTIASAHKLVNFQGYLPGKEVVILGRNEWALLLARRLIIEGANIKALIDYSESGFITEDELKIIDGFHINIIENSRIIEISGKERIQNVVIENIANGVLSNIQCDSLILTVGYYPEIDFITKANIELDEEDVPEVCDYEISIKNIYACGTILHGESGVLNSGEEGYKVGKIVSEKIKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE0</accession>
    <name>A0A386PFE0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">CP523_06550</name>
        <name evidence="11" type="ORF">EI377_01035</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677466.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02187"/>
    <dbReference type="EnsemblBacteria" id="AYE34157">
        <property type="protein sequence ID" value="AYE34157"/>
        <property type="gene ID" value="CP523_06550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59525">
        <property type="protein sequence ID" value="QAS59525"/>
        <property type="gene ID" value="EI377_01035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06550"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="328" mass="36005" checksum="A8C0D7B170BEBA42" modified="2018-12-05" version="1">MAILVCGGAGYIGSHMVAELLENGQEVVVLDNLAKGHKDALLGGKLYVGDLRDRKILDKVFTENKIDAVIDFAADSLVGESMTEPLKYFNNNVYGTISLLEAMRDYNVKYIVFSSTAATYGEPDEIPILENSKTIPTNPYGESKLLVEKILRWADHAYGIKYTALRYFNAAGAHISGKIGEDHSPESHLIPIILSVALGNRDKIMMYGDDYPTADGTCVRDYIHVSDLASAHSLALRRLMNGGDSAIYNLGNGAGFSVKEVVEIARKVTGHPIPAEVAPRRAGDPAVLIASSEKAVKELNWKPKYNSLENIIETAWNWHKNHKNGYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH1</accession>
    <name>A0A386PFH1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="4" type="ORF">CP523_09020</name>
        <name evidence="5" type="ORF">EI377_03765</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876948.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00244"/>
    <dbReference type="EnsemblBacteria" id="AYE34550">
        <property type="protein sequence ID" value="AYE34550"/>
        <property type="gene ID" value="CP523_09020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59950">
        <property type="protein sequence ID" value="QAS59950"/>
        <property type="gene ID" value="EI377_03765"/>
    </dbReference>
    <dbReference type="GeneID" id="66300463"/>
    <dbReference type="KEGG" id="csep:CP523_09020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="84" mass="9886" checksum="B416484BFC4935B9" modified="2018-12-05" version="1">MERGLRKKKIGRVVSDKMEKTIVVAVETKVRHPLYGKTVNRTTKFKAHDENNEAKINDRVLIMETRPLSKDKRWRLVEIVEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH7</accession>
    <name>A0A386PFH7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03670</name>
        <name evidence="6" type="ORF">EI377_14200</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677705.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02211"/>
    <dbReference type="EnsemblBacteria" id="AYE33628">
        <property type="protein sequence ID" value="AYE33628"/>
        <property type="gene ID" value="CP523_03670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61792">
        <property type="protein sequence ID" value="QAS61792"/>
        <property type="gene ID" value="EI377_14200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="344" mass="39077" checksum="C20B2B2F0D1DE0D9" modified="2018-12-05" version="1">MKVTIKDVAREANVATSTVSRVLSNSSQISKETKDRVNAAIKKLNYTPNIIARGLANKKTNILAVVIPEKAEMIFANPFFIQAMKGVSICAEKENYYIMYAFKEEDKNDEEHIRRFIDSNLVDGICLFRAKDHDPYIDYLKDKKFPFVVIGRPEEANNVLWVDNDNFKAMYDLTNKLIDMGHEKIGFIGANMSLNVSKDRLKGYKQGLLSRGIEIEEKLICEVDEFKEECGYNAAKKMLKYTKPTAIVATDDIMAFGVQDLLRELDIEGISVIGFNNIPLADYRIPKLSSVDINSEKLGFYAAKLLIDNLNKSDNRTNYIIDTKLIMRESLKENNAIGCINKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL1</accession>
    <name>A0A386PFL1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_05905</name>
        <name evidence="12" type="ORF">EI377_00395</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675030.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01884"/>
    <dbReference type="EnsemblBacteria" id="AYE34034">
        <property type="protein sequence ID" value="AYE34034"/>
        <property type="gene ID" value="CP523_05905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59407">
        <property type="protein sequence ID" value="QAS59407"/>
        <property type="gene ID" value="EI377_00395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="431" mass="47378" checksum="1FDB94C5FDA3C6EB" modified="2018-12-05" version="1">MERQLALDLIDFLYESPSAFHSVVTVKNVLDKNGFKEVKESERWNLQKEGKYYVRKNDSAIIAFVIGNGDLCDNGFRLIGAHTDAPGFRIKPNPEMTAEGKYLKLNTEVYGGPILYTWFDRPLGIAGKVTVKGENPLKPEIKLVKIAKPLLIIPSLAIHMNRAVNEGFNINRQKDTLPLLGLINEKFEKDNYLLKLLAEELKVNIEDIIGFDLGLFEVEKGCIMGMNEELISTGRLDDMWMVYAGVKALVDSKVNSATKVMVCIDNEEIGNLTAQGASSILLINVLERIALALGKDREDFHRTLSNSVMISADLAHAVHPNSGEKHDPTNRPVLEGGPVLKIAAAGSYSTDSYSAAVFEGVCKAANVPYQKFVNRSDVKGGTTIGPVTAAGLAIPVIDMGAPVLSMHSIKELTSVKDNYYTIKAFTEFFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN8</accession>
    <name>A0A386PFN8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_09320</name>
        <name evidence="11" type="ORF">EI377_04065</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678011.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02721"/>
    <dbReference type="EnsemblBacteria" id="AYE34610">
        <property type="protein sequence ID" value="AYE34610"/>
        <property type="gene ID" value="CP523_09320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60010">
        <property type="protein sequence ID" value="QAS60010"/>
        <property type="gene ID" value="EI377_04065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="9">
        <location>
            <begin position="731"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1027" mass="119058" checksum="1DA51233C6F2594B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR7</accession>
    <name>A0A386PFR7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB</name>
        <name evidence="7" type="ORF">CP523_11000</name>
        <name evidence="8" type="ORF">EI377_05795</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677676.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02534"/>
    <dbReference type="EnsemblBacteria" id="AYE34893">
        <property type="protein sequence ID" value="AYE34893"/>
        <property type="gene ID" value="CP523_11000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60288">
        <property type="protein sequence ID" value="QAS60288"/>
        <property type="gene ID" value="EI377_05795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="5"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="350" mass="40317" checksum="3F284112DD3E4A54" modified="2018-12-05" version="1">MKTYLVTGGAGFIGSNFVLYILKKYNDIRIINLDKLTYAGNLENLKAIEGDKRHIFVQGDICDKELVSSLFEKYEIDYVVHFAAESHVDRSIKEPEIFVKTNVLGTVNLLNCAKNAWEVNDGWKEGVKFLHVSTDEVYGSLGETGYFMETTPLDPHSPYSSSKASSDLMVKAYADTYKMPINITRCSNNYGPFQFPEKLIPLLINNCLQHKDLPIYGDGMNIRDWLFVEDHAKAIDMVINNGRLGEVYNVGGHNERTNIQIVDTVINYINENVDKEVTENLKKFVEDRKGHDRRYGIDPTKIKEELGWYPETTFEVGIVKTIKWYLDNKNWMENITSGDYQNYYNEMYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU4</accession>
    <name>A0A386PFU4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00878"/>
    <dbReference type="EnsemblBacteria" id="AYE33881">
        <property type="protein sequence ID" value="AYE33881"/>
        <property type="gene ID" value="CP523_05025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="60" mass="6895" checksum="F10B58A1C8AB0535" modified="2018-12-05" version="1">MCTVLGVARSTYYKCFDKIKSVREIENNEELKAAIIRIYEDNKGIYGDPMIHHILGTEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW3</accession>
    <name>A0A386PFW3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YlmC/YmxH family sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00630</name>
        <name evidence="3" type="ORF">EI377_11120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00657"/>
    <dbReference type="EnsemblBacteria" id="AYE33059">
        <property type="protein sequence ID" value="AYE33059"/>
        <property type="gene ID" value="CP523_00630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61228">
        <property type="protein sequence ID" value="QAS61228"/>
        <property type="gene ID" value="EI377_11120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014238">
        <property type="entry name" value="Spore_YlmC/YmxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02888">
        <property type="entry name" value="spore_YlmC_YmxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="108" mass="12589" checksum="33FFB4BCCD4901C4" modified="2018-12-05" version="1">MRRVDRRKQEYYDVEERQESRYRLLSDLERYEIFNTEEAEKYDTQHALDFIIDEDGNLQFIVAAVAGSKFGFFGGREYVEIPWGYVTKVGANVIVVSADGGKIRRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ9</accession>
    <name>A0A386PFZ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Hemolysin III family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_07985</name>
        <name evidence="8" type="ORF">EI377_02745</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675918.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00712"/>
    <dbReference type="EnsemblBacteria" id="AYE34367">
        <property type="protein sequence ID" value="AYE34367"/>
        <property type="gene ID" value="CP523_07985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59773">
        <property type="protein sequence ID" value="QAS59773"/>
        <property type="gene ID" value="EI377_02745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="23863" checksum="C88DD470CCCB0172" modified="2018-12-05" version="1">MEKHLREPINSLTHWIGAILSILALIAMLIKGFNNNLSSLQILSVVIFGVSLILLYSVSATYHSVISSDDIILKLRKLDHSTIFILIAGSYAPFCLIALGGKLGISFFILMILIAISGVIFKLCWFNCPRWLQTALYIGMGWSAIFVIKPLSQVMSPTSIFWLVLGGVLYTLGGVLYALKPKKLQLGAFGFHEIFHIFILLGSLSHFISVFIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG15</accession>
    <name>A0A386PG15_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11535</name>
        <name evidence="4" type="ORF">EI377_06350</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YejK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673329.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02865"/>
    <dbReference type="EnsemblBacteria" id="AYE34995">
        <property type="protein sequence ID" value="AYE34995"/>
        <property type="gene ID" value="CP523_11535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60388">
        <property type="protein sequence ID" value="QAS60388"/>
        <property type="gene ID" value="EI377_06350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007358">
        <property type="entry name" value="Nucleoid_associated_NdpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04245">
        <property type="entry name" value="NA37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="347" mass="40352" checksum="D1BFB998410EF9D6" modified="2018-12-05" version="1">MEYINDINIQEAVIHIIDSNGDEPILNEYTLDLNEDIYKFLYRHIEKCFKDEELKYAVFNPERNIVKELVQDYLNEIEGSEIIALSQELARQLFIIMKSNVNIPSCDLIVVSLITDQGPMIGILKMDYVKNFTHQVEFVENKIGIGIVPQSTGLPGSSQRIQKAAFIKPIREENKYDLMVIDKQRKSKDQDEYGANYFIANFLGCSLITNERDMTKTLLKAAETWTRSNVTEDADRAEKIRTTVKSKLKEEECINIDALSHELFREEPQIKENFSNFVKSHGLEDEVTVDKQWVEKKLKRVRLKIDKEIDLYIDEEAYHDSSKFEIQRNGDGSINMIIKHVVNYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG36</accession>
    <name>A0A386PG36_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04845</name>
        <name evidence="3" type="ORF">EI377_15355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33848">
        <property type="protein sequence ID" value="AYE33848"/>
        <property type="gene ID" value="CP523_04845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61994">
        <property type="protein sequence ID" value="QAS61994"/>
        <property type="gene ID" value="EI377_15355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04845"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="159" mass="18242" checksum="F38F6F2539E50611" modified="2018-12-05" version="1">MLETDGGDTMFKYYEKTSKFNTRGFSETWLRLFIFIILLVNLFNIFILGPILEIPLSNIDFFYLSIILSGILSGCAASYLKIEIETLKVSNTEEFIKVINFVLPQMAYYPESKIDNFITFKPSFEVGLFSSRVTIHIDNNSVTIMGPKNIVKRLKNITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG46</accession>
    <name>A0A386PG46_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminopeptidase P family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Peptidase M24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_08250</name>
        <name evidence="5" type="ORF">EI377_03000</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674721.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01592"/>
    <dbReference type="EnsemblBacteria" id="AYE34417">
        <property type="protein sequence ID" value="AYE34417"/>
        <property type="gene ID" value="CP523_08250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59822">
        <property type="protein sequence ID" value="QAS59822"/>
        <property type="gene ID" value="EI377_03000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="422" mass="49013" checksum="DDFC9C2552524CB0" modified="2018-12-05" version="1">MNKQFYKVNREKVLKEIKDNSLVILFAGNAPKKTADEKYPFTPNRNFYYLTGIDEEEHILLMSKINGNIKSTLFIKEIDPILEKWQGKSVRKDEAFEISDVDEVEYLGSFKNVLHKIITSREDFNVYLDLEKDSYNSPETLAENISWEIFKKYPQVNIKNIYRIISKFRLVKSEEEIQRIQKAIDITIEGVKNLMKICTPGMKEYELEAYFDLTCKTKGVRDFAFKTIAASGKNAAVLHYVDNNSEIKDGQLILFDLGAQYNYYNGDISRTFPVNGKFTERQKDVYNSVLRVNERVIKSMKPGVSFIELNKQARKWIAEECIKLGLIEKEEEVSKYYYHSIGHSLGMDTHDIEPPNRDVIFEAGMVYTVEPGIYIEDESIGIRIEDDVLITEDACEVLTKDMIKTVEDIEEFMLNNKNTLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG57</accession>
    <name>A0A386PG57_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35045">
        <property type="protein sequence ID" value="AYE35045"/>
        <property type="gene ID" value="CP523_11820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="134" mass="15833" checksum="A939C3113C93CEA3" modified="2018-12-05" version="1">MRLMYFYFLLIFNITLIVAGLLGSILTLSMLLRKRINKGYYLLVLLLVYCSISVFKYHVIPMVKDLTIIKNDSYKTFNGTCENISIGVNRTISIDGKRFYYNSWNFTPKPKENYHIYYMPNSNFIIDLEKNNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG63</accession>
    <name>A0A386PG63_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678414.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33522">
        <property type="protein sequence ID" value="AYE33522"/>
        <property type="gene ID" value="CP523_03090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="178" mass="19943" checksum="668D62CD99F04D0E" modified="2018-12-05" version="1">MKQRALDIQVEISALNYKVEDEAIAEIQELPTVLGVDEHIKALTSGLIDKKTWLIVCTNKRVLMLDKGIIYGLELIDIPLDRINSISHCKGFLYGKISITDGTTTRTIENVPNITVSFFADAVNKEMEIYKQSKTTPLTQVANTKSAADELIKYKQLLDMGALTQEEFNVKKKELLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG78</accession>
    <name>A0A386PG78_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05840</name>
        <name evidence="4" type="ORF">EI377_00325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675005.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01871"/>
    <dbReference type="EnsemblBacteria" id="AYE34021">
        <property type="protein sequence ID" value="AYE34021"/>
        <property type="gene ID" value="CP523_05840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59393">
        <property type="protein sequence ID" value="QAS59393"/>
        <property type="gene ID" value="EI377_00325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="396" mass="43830" checksum="5967B8D8BACB8E7F" modified="2018-12-05" version="1">MAKLVINQDKVGDINELIKICPFGALENNNGKLEINASCKMCKLCVRKGPKGAVEYVEEEVKKIDKSKWNGIAVYVDHVDGEIHPVTFELIGKARELAKKINHKVYCVFIGTNIKHKAEELLHYGVDEVFVYDKPQLKYFTIEPYTVAFAEFINSVKPSSILVGATTVGRSLAPRVAARFRTGLTADCTILDIKENTDLVQIRPAFGGNIMAQIVTPNSRPQMATVRYKVMSAPEREDEIRGKVTICNVDDSKLNSNIEVKKVTKKEKEHSISEAEVIVVAGRGVKSEKDLKMIEELADLLGGEVACTRPLIESGWFDAKKQVGLSGRTVRPKLIIACGVSGAVQFTAGMNNSDYIFAINKDEKAPIFEAAHYGVIGDIYEVVPQLIEKIKMERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG96</accession>
    <name>A0A386PG96_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Silent information regulator protein Sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_01355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00822"/>
    <dbReference type="EnsemblBacteria" id="AYE33199">
        <property type="protein sequence ID" value="AYE33199"/>
        <property type="gene ID" value="CP523_01355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="PTHR38481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="SSF49863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017420485" evidence="6">
        <location>
            <begin position="33"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1281"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="1275"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1306" mass="147910" checksum="DF65A500C88B8663" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA2</accession>
    <name>A0A386PGA2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54-dependent Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_05170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01823"/>
    <dbReference type="EnsemblBacteria" id="AYE33908">
        <property type="protein sequence ID" value="AYE33908"/>
        <property type="gene ID" value="CP523_05170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="147"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="465" mass="52574" checksum="4E30647AE39E225A" modified="2018-12-05" version="1">MELMRDGVYFDILNTIMDSVNEWVVVVNKDARITMMSKSYKEFLGDFTPEGKLVTDVIENTKMHEIVKSGKTIAGDIQYIRGNRMIAIRVPIKRDGVVIGAVGKVMFKDISDYYSLGKQIAKLERAVEYCKSELGHERAAKYFFSDIVGKSKENLKVKEIALRAARTKSNVLIIGESGTGKELLAHAIHNASDRRGKPFVKINCAAIPGELLESELFGYEEGAFTGAKKCGKKGKFELANNGTILLDEIGDMPMASQAKLLRVLQDREIEKVGGNIVKKIDVRVISSTNKNLKKAIEDGTFREDLYYRLNVINIKVPPLRMRKDDIDALVNVLRRKIADKLGIYVEGISKEAINILKDYNWPGNIRELENVIESSINMLESDVYIGKDHLPEKLIRSSKSIYIKSSEKKFLKDIVAEVEKKVILDCLNSVQWNKNKAAKILGISRVGLYKKIEYYNLIDDNFKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA3</accession>
    <name>A0A386PGA3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675595.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00833"/>
    <dbReference type="EnsemblBacteria" id="AYE33209">
        <property type="protein sequence ID" value="AYE33209"/>
        <property type="gene ID" value="CP523_01410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="183" mass="21801" checksum="402B47C19153B8F9" modified="2018-12-05" version="1">MNAINLMMEEHKNIKIMLKIVRKACFNILNSSEVDYEDFYLIIDFIRNYADSHHHKKEEVMLFNKMIDEMGSTAEKLVKYGMLVEHDLGRLYISELENSLKKMKYGDKEAKLDIIANAISYTNLLERHIEKEDNVVYKFAERELKEDTLLEINNECIKFEEENNKVKIENLKILETLRNKYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD8</accession>
    <name>A0A386PGD8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03530</name>
        <name evidence="2" type="ORF">EI377_14055</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677927.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33602">
        <property type="protein sequence ID" value="AYE33602"/>
        <property type="gene ID" value="CP523_03530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61766">
        <property type="protein sequence ID" value="QAS61766"/>
        <property type="gene ID" value="EI377_14055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="186" mass="22218" checksum="DF3C575081770A68" modified="2018-12-05" version="1">MSNLEKFITNLCGEFDNSDQIKEEVKLNKLNHPKARHINGICNSKIKNLPKDFKGYFIIEESYYEKDNFKNVLPHLFLFTLNEDNKIVLTSYEIPKNIKKEEFRNDNKDLLMDYNELILSEKFKPMVYNEENEIFQGESISYFSAENKFTLRERIENDIIYVSEVFEKNGKITFGFLDPIIYKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD9</accession>
    <name>A0A386PGD9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication protein DnaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07430</name>
        <name evidence="3" type="ORF">EI377_02120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673792.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01095"/>
    <dbReference type="EnsemblBacteria" id="AYE34294">
        <property type="protein sequence ID" value="AYE34294"/>
        <property type="gene ID" value="CP523_07430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59688">
        <property type="protein sequence ID" value="QAS59688"/>
        <property type="gene ID" value="EI377_02120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="181"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="324" mass="38186" checksum="9CDE247A396F3437" modified="2018-12-05" version="1">MIKGYQKELANIYENIRTTEQKKLNKRREEISNKYPEIMELDKLIQKQSLNLSLSILKGLNEKQIEEIKDTITDLRFKKYEALVSKGYDPEYLSLHYQCSKCKDEGYIGVNKCSCYKSKLVKLYYQDSDLEEAVKINNFNNFDINLYSNHKIGEDKFSPRRNIENIIEFIKGDYIPNFSNHNSNLLFYGNSGTGKTYLSWCIAKDLLDRGFLVVYKTSDELIKCLRDIRFNNNYELEELLLNCDLLIIDDLGAEQITEFSATELFTLINKKLLKNKKMIISTNLSLPMITKIYSERIYSRLVGNFKLYKFYAEDIRIQLNLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL3</accession>
    <name>A0A386PGL3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_11135</name>
        <name evidence="10" type="ORF">EI377_05925</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677065.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00913"/>
    <dbReference type="EnsemblBacteria" id="AYE34920">
        <property type="protein sequence ID" value="AYE34920"/>
        <property type="gene ID" value="CP523_11135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60314">
        <property type="protein sequence ID" value="QAS60314"/>
        <property type="gene ID" value="EI377_05925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26665" checksum="4A6D2EC4DCFB80E9" modified="2018-12-05" version="1">MEKKDINILIVEDDTDINGLLYQILLTEGYNVKQAFSGTEAKMCLDIFKFDLVLLDLMLPGMTGEEIIREVRKVKNMPIIVISAKTKQEDIINVLKMGADDFVLKPFNVKEVLARVEAQLRRYTKFSKEEESNILRYKELQLDKDLVEIKVKGQIVQATAKEFAIVELLMEHPKKVFTRANIFEHVWNEEFLGDDNTVNVHVSNIRSKISAVDKENEYIKTVWGIGFKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN8</accession>
    <name>A0A386PGN8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Arsenate reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09205</name>
        <name evidence="3" type="ORF">EI377_03950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678335.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03057"/>
    <dbReference type="EnsemblBacteria" id="AYE34587">
        <property type="protein sequence ID" value="AYE34587"/>
        <property type="gene ID" value="CP523_09205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59987">
        <property type="protein sequence ID" value="QAS59987"/>
        <property type="gene ID" value="EI377_03950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="116" mass="13572" checksum="E9B41A9FD3D1C679" modified="2018-12-05" version="1">MIFVEYPKCTTCKRAKKFLTDNNIEFIDRNIIENNPTKEELKEWIEKSGLPINKFFNTCGKLYREMGLKDKVKTLKEDELLDILASDGMLVKRPILVNSDKVLIGFKEENWIEATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS5</accession>
    <name>A0A386PGS5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_01640</name>
        <name evidence="9" type="ORF">CP523_06185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33253">
        <property type="protein sequence ID" value="AYE33253"/>
        <property type="gene ID" value="CP523_01640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34088">
        <property type="protein sequence ID" value="AYE34088"/>
        <property type="gene ID" value="CP523_06185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01640"/>
    <dbReference type="KEGG" id="csep:CP523_06185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="406" mass="46735" checksum="0D1B870702F3C9B6" modified="2018-12-05" version="1">MSFSKKELIKILAKDPNIKTAEDIQNVLKDLFGGMLQQMLEAELDNHLGYEKHDYQNKNTTNSRNGKSRKTMKSNLGYFDLDVPRDREGSFEPEIVKKHQTDVSHLESSIIGMYAKGMTTRDIASQVNEIYGMDISPTLVSNITDKVIPMIREWQSRPLETVYPIVFMDAIHFKVRKDNTVVSKAAYAAIGVNIEGKKDVLGIWIGASESSKYWLLVLNELKNRGVKDILIASVDGLVGFNEAIRAVYPNTEIQRCIIHQIRNSSKYLSYKDLKAFNADLKLVYTASTEEVALAELDRLEEKWGEKYLIAVRSWRNNWNELSTFFKYPPEIRKIIYTTNAMESYNRQLRKVTKTKSIFPNDESLMKILYLATVDITKKWTQSIRGWAQILAQLSIFFEGRLDDQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY3</accession>
    <name>A0A386PGY3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06505</name>
        <name evidence="3" type="ORF">EI377_00985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677450.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02178"/>
    <dbReference type="EnsemblBacteria" id="AYE34148">
        <property type="protein sequence ID" value="AYE34148"/>
        <property type="gene ID" value="CP523_06505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59516">
        <property type="protein sequence ID" value="QAS59516"/>
        <property type="gene ID" value="EI377_00985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="274" mass="29750" checksum="EA28C9027CC69533" modified="2018-12-05" version="1">MKNNISELKSIAQLIRGDIVTMLTESCSGHPGGSLSSADIVTALFFGEMNIDAKNPNDENRDRFVLSKGHAAPVLYSALARRGYFEVEELKTLRKFGSRLQGHPSMKCLPGVDMSTGSLGQGISAAIGMALAGKIDNKSYRVYTLLGDGELEEGQVWEASMAAAHYKLDNLTAFIDFNGLQIDGNVEEVMNPSPIDKKFEAFGWNTIVIDGHSMEEILKAIESAKQCKEMPTAVICKTIKGKGVSFMENEASWHGTTPNKEQCNQALAEIGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH40</accession>
    <name>A0A386PH40_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08780</name>
        <name evidence="2" type="ORF">EI377_03540</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678079.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02697"/>
    <dbReference type="EnsemblBacteria" id="AYE34504">
        <property type="protein sequence ID" value="AYE34504"/>
        <property type="gene ID" value="CP523_08780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59907">
        <property type="protein sequence ID" value="QAS59907"/>
        <property type="gene ID" value="EI377_03540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="24215" checksum="890BB2509849B952" modified="2018-12-05" version="1">MEIEWFGSTTFILKNSIGKRVLIDPLEAISNKKNYDFDVDIITLSHTPNNKSLKQYITKECTIINDTSSFANEYLTIDGYTSYKDNMNGFKRGENNIYLFNIDGFKLCHLGTVGHILDNKLISKLKNLDFLFIPIGGHFALNGIDAAKLTLDITPKYIIPMFYRNMDEYPYLDGPHKFLSHMKNIKKYNTRSIQTSSLYFKNNNTVLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH53</accession>
    <name>A0A386PH53_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05315</name>
        <name evidence="3" type="ORF">EI377_15875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676282.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33936">
        <property type="protein sequence ID" value="AYE33936"/>
        <property type="gene ID" value="CP523_05315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62087">
        <property type="protein sequence ID" value="QAS62087"/>
        <property type="gene ID" value="EI377_15875"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="29187" checksum="475712EE0F7B6A31" modified="2018-12-05" version="1">MKKLNFKNPGIWYVIIFLIIAILNSLFDFFFSRLYLINNILINFVPAIIFYVFYKVRKRIKYKYLIVSINVTLVIISIILLLTNFMFGCFTELFTPIDDINYYHRVLRVRNNYNYELMYHFPKSIPKNSKDIKFGDAYGFSGGGYECDLTYTSEDKINLTEYQQSSKYVIHNREDLNKCKENLHLPYYILENLGLNNLNNYDETVKEKNYIIYVLKLKDSEHGYSSGLAVNEDTNRVFYWSYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB8</accession>
    <name>A0A386PHB8_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12580</name>
        <name evidence="3" type="ORF">EI377_07485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675249.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35190">
        <property type="protein sequence ID" value="AYE35190"/>
        <property type="gene ID" value="CP523_12580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60594">
        <property type="protein sequence ID" value="QAS60594"/>
        <property type="gene ID" value="EI377_07485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362720" evidence="1">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="179" mass="20179" checksum="09DE4ECB7EF0763C" modified="2018-12-05" version="1">MIKKTFKKILSSAVATGLLMGGIPFLSANAATNESVEVIKLSQENLQQLNYAIEEMRIAIDLVDNADFTNIDNYNRLLIFATTSLERSRGLGIENQYIDSIEESGNEVRELTYRITRVLQAINNVEIVFSEERNDTKENKENVVNTLNEVLTQEIQAGELNENTLRSAVNILHQYVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE0</accession>
    <name>A0A386PHE0_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">Stage II sporulation protein E</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="ORF">CP523_08615</name>
        <name evidence="4" type="ORF">EI377_03365</name>
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    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674891.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01664"/>
    <dbReference type="EnsemblBacteria" id="AYE34481">
        <property type="protein sequence ID" value="AYE34481"/>
        <property type="gene ID" value="CP523_08615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59883">
        <property type="protein sequence ID" value="QAS59883"/>
        <property type="gene ID" value="EI377_03365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014221">
        <property type="entry name" value="SpoII_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045768">
        <property type="entry name" value="SpoIIE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19732">
        <property type="entry name" value="SpoIIE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02865">
        <property type="entry name" value="spore_II_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="165"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="577"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="795" mass="87853" checksum="333888FF1A4E9661" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK7</accession>
    <name>A0A386PHK7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zapA</name>
        <name evidence="2" type="ORF">CP523_14615</name>
        <name evidence="3" type="ORF">EI377_09585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678659.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00189"/>
    <dbReference type="EnsemblBacteria" id="AYE35563">
        <property type="protein sequence ID" value="AYE35563"/>
        <property type="gene ID" value="CP523_14615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60950">
        <property type="protein sequence ID" value="QAS60950"/>
        <property type="gene ID" value="EI377_09585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34981">
        <property type="entry name" value="PTHR34981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="25195" checksum="B5F554002F9DD7C1" modified="2018-12-05" version="1">MNTVTIKINGIEYNLKGRENEKYLLQIAEYVDGKVKDIMGNNKKLSSTAAATLVSLNIADELFKADMEIENLIKDRNTLEEKKIIFSERIKEIKSEYDKIINEKDDEIKKLQAIISSMEERLENAEKLVEVLEDKKSDDEYKEKFEKLGQEVVIMEEELKKNIKQKRLLEERNKDIKFQLQNSKYKVLDLENKLVDLQIELAKERKNKNVLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK9</accession>
    <name>A0A386PHK9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13075</name>
        <name evidence="4" type="ORF">EI377_07945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677838.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02556"/>
    <dbReference type="EnsemblBacteria" id="AYE35280">
        <property type="protein sequence ID" value="AYE35280"/>
        <property type="gene ID" value="CP523_13075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60674">
        <property type="protein sequence ID" value="QAS60674"/>
        <property type="gene ID" value="EI377_07945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="387"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="640" mass="74762" checksum="A32BECFF57902832" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT1</accession>
    <name>A0A386PHT1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04195</name>
        <name evidence="3" type="ORF">EI377_14720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33729">
        <property type="protein sequence ID" value="AYE33729"/>
        <property type="gene ID" value="CP523_04195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61886">
        <property type="protein sequence ID" value="QAS61886"/>
        <property type="gene ID" value="EI377_14720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="97" mass="11110" checksum="BF3DB256D01DD39A" modified="2018-12-05" version="1">MRGQHYTDEQKEQILQEVKEVGNVSLVGRKHGISTSTIFTWISKSKNRDQIKTKPGRKTSVEGKSNEEEINEVTQENDKLKKILGEKDLEISILKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU2</accession>
    <name>A0A386PHU2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="11">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="11">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="11">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="9" type="primary">nnrD</name>
        <name evidence="10" type="synonym">nnrE</name>
        <name evidence="13" type="ORF">CP523_06525</name>
        <name evidence="14" type="ORF">EI377_01010</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10 11">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 9 11">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 9 11">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10 11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 11">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="11"/>
    <dbReference type="EC" id="5.1.99.6" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02182"/>
    <dbReference type="EnsemblBacteria" id="AYE34152">
        <property type="protein sequence ID" value="AYE34152"/>
        <property type="gene ID" value="CP523_06525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59520">
        <property type="protein sequence ID" value="QAS59520"/>
        <property type="gene ID" value="EI377_01010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
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        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9 11" id="KW-0521">NADP</keyword>
    <keyword evidence="9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="54"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="10">
        <location>
            <begin position="130"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
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        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="410"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS59520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="500" mass="54907" checksum="BD6AEDD8336218D3" modified="2018-12-05" version="1">MYILSVDKCKKLDGYTISNIGIPSIVLMENAAEKIINKIKGKADKFLVICGVGNNGGDGLAIARKLILQDKCVEIIIVNEKSKYTNDFNINLNILKNMECSIKYIKTNKDINILDDMLNKFDIIVDCIFGVGLNRNLNDFYINIIKAINNCKAFKVSVDVPSGLNGDTGKEMGEAIRADITYTFEAIKKGFIEYNALEYLGDLEVISIEIPKVVKDMHNEKIVTLSKSEYSNRLNKRSLYGHKGTYGKVAIFAGERGYTGAAYITTESCVKTGTGLTTLISSKYVQDILSTKLVEAMTLDISDEVEVKNILNDLDAIAFGPGLKGSKEALKSLENIIYNTKIPIVIDAEGINILSENRELLNDLNGRAVITPHPGEMARLIGKSIKEVESNRIEIAKRYAKKNNVVLLLKGYNTVITDGNFVYINKTGNSKMASGGMGDCLTGIITSLIAQKHSIFDSAILGAYIHGLAGERAGEHEYSTVATKVIDEIPKVMESILKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ4</accession>
    <name>A0A386PHZ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS mannitol transporter subunit IIB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PTS sugar transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11445</name>
        <name evidence="4" type="ORF">EI377_06260</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673288.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02846"/>
    <dbReference type="EnsemblBacteria" id="AYE34977">
        <property type="protein sequence ID" value="AYE34977"/>
        <property type="gene ID" value="CP523_11445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60370">
        <property type="protein sequence ID" value="QAS60370"/>
        <property type="gene ID" value="EI377_06260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="91" mass="9879" checksum="70AEEEB2C7FCB5AA" modified="2018-12-05" version="1">MKKIMAVCGSGLGSSFMVEMNITDVLRELGVDDQYEASHTSLADVVASDADIFVTGIDLADSASHLPELIILDSLLDRDELKRKIQEKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI19</accession>
    <name>A0A386PI19_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ispD</name>
        <name evidence="8" type="ORF">CP523_08850</name>
        <name evidence="9" type="ORF">EI377_03605</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678110.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02710"/>
    <dbReference type="EnsemblBacteria" id="AYE34518">
        <property type="protein sequence ID" value="AYE34518"/>
        <property type="gene ID" value="CP523_08850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59920">
        <property type="protein sequence ID" value="QAS59920"/>
        <property type="gene ID" value="EI377_03605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08850"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="25265" checksum="4331753F072A9145" modified="2018-12-05" version="1">MVSAIVLAGGKGKRMGAGISKQYIELNNKPILYYTLKKFIDCTHIDKVILVLPEDEIEYCKKEVLDKYSLKVDRLVKGGKERQDSVLNALLSIKDTDIVLIHDGARPFVSEDVIKNGISLARLYGAAAPGVMPKDTIKLKDKSGFSIETPKRENLVSIQTPQVFKFDIILECHKKIKSEEISVTDDTMVVEKYNNKVYLYEGDYTNIKITTPEDLILGERLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI38</accession>
    <name>A0A386PI38_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14105</name>
        <name evidence="2" type="ORF">EI377_09010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678468.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35470">
        <property type="protein sequence ID" value="AYE35470"/>
        <property type="gene ID" value="CP523_14105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60857">
        <property type="protein sequence ID" value="QAS60857"/>
        <property type="gene ID" value="EI377_09010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="74" mass="8821" checksum="180E561047DB083C" modified="2018-12-05" version="1">MGWQERVNEQKEKILKNIEYGKSIGVNKISAIFMLEDAEKDKIEKELITWLILDGYRVELKQDEVKILIIEWNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI52</accession>
    <name>A0A386PI52_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6 8">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplP</name>
        <name evidence="10" type="ORF">CP523_09010</name>
        <name evidence="11" type="ORF">EI377_03755</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678360.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00242"/>
    <dbReference type="EnsemblBacteria" id="AYE34548">
        <property type="protein sequence ID" value="AYE34548"/>
        <property type="gene ID" value="CP523_09010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59948">
        <property type="protein sequence ID" value="QAS59948"/>
        <property type="gene ID" value="EI377_03755"/>
    </dbReference>
    <dbReference type="GeneID" id="66300461"/>
    <dbReference type="KEGG" id="csep:CP523_09010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="144" mass="16370" checksum="2DDA8EE100CD86CE" modified="2018-12-05" version="1">MLMPKRVKHRKVQRGRMKGKATRGNFLAYGDYGIQATTCGWITSNQIESARIAINRYIRRGGKLWIKIFPDKPVTEKPAETRMGSGKGSPEYWVAVVKPGRVLFELSGVNEEVAREAMRLASHKLPVKCKFVTRRDFEEMGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC2</accession>
    <name>A0A386PIC2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09310</name>
        <name evidence="4" type="ORF">EI377_04055</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678007.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34608">
        <property type="protein sequence ID" value="AYE34608"/>
        <property type="gene ID" value="CP523_09310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60008">
        <property type="protein sequence ID" value="QAS60008"/>
        <property type="gene ID" value="EI377_04055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="276" mass="32567" checksum="33D803A961542497" modified="2018-12-05" version="1">MKNIFDIFSTDKRPSKELFIYECGYEQCKPRDPYQYEQIDYYLIHYILSGEGLFFMNNQVYKLKKGDGFLIPPHTDNNYYPIPDNPWSYRWIGINGTEASRLLNLCGFNSSKFIFNYTEDDFIENCFKNILDSCNNGQDFQALGNLYLFLNKLIIKNDKNSNISITSAANYITLFINDIHNNYNKNISISDIASNININRSHLFKLFKKHMNMSPQQYFINYRLNKACELLRKSSYSISEIGYLVGFNSPSYFSKIFSKYKDISPMEYRKMFIKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID6</accession>
    <name>A0A386PID6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12205</name>
        <name evidence="3" type="ORF">EI377_07025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673569.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02996"/>
    <dbReference type="EnsemblBacteria" id="AYE35117">
        <property type="protein sequence ID" value="AYE35117"/>
        <property type="gene ID" value="CP523_12205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60508">
        <property type="protein sequence ID" value="QAS60508"/>
        <property type="gene ID" value="EI377_07025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="57" mass="6173" checksum="7470D92CB4ACE720" modified="2018-12-05" version="1">MSKVCLCKGVSEEEIVKAIKEGAITFEEVREKTGAGSGFCHAGRCKGKIETLIEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG5</accession>
    <name>A0A386PIG5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rex</name>
        <name evidence="9" type="ORF">CP523_09550</name>
        <name evidence="10" type="ORF">EI377_04295</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676672.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02616"/>
    <dbReference type="EnsemblBacteria" id="AYE34648">
        <property type="protein sequence ID" value="AYE34648"/>
        <property type="gene ID" value="CP523_09550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60047">
        <property type="protein sequence ID" value="QAS60047"/>
        <property type="gene ID" value="EI377_04295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="80"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="219" mass="24883" checksum="9FCFC7551C62E36F" modified="2018-12-05" version="1">MEKKKNISMAVIKRLPKYHRYLQELMRNDVDRISSKELGEKIGFTASQIRQDLNCFGDFGQQGYGYNVRDLYKQISVILGLNKEYKTLIVGAGNIGQAVANYSRFSELGLSLKGIFDANPKLIGLRMRGIEIQDIDYLESFLRNNSIDIGMICVPRINAQKVCDTLIQGGVKGIWNFAPVDLVVPEDVIVENVHLSESLLTLIYLLHKDDREDEKKIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR4</accession>
    <name>A0A386PIR4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11920</name>
        <name evidence="2" type="ORF">EI377_06740</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673452.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35064">
        <property type="protein sequence ID" value="AYE35064"/>
        <property type="gene ID" value="CP523_11920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60457">
        <property type="protein sequence ID" value="QAS60457"/>
        <property type="gene ID" value="EI377_06740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="71" mass="8537" checksum="1DA02BFFB53317E8" modified="2018-12-05" version="1">MSKCPFWSTTREKVSCYNECPMNKSIQEDEICPFKEHLTTKLIYKDIINEDYAYSQDEYFGYNLTDNIINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ11</accession>
    <name>A0A386PJ11_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11665</name>
        <name evidence="6" type="ORF">EI377_06485</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673624.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02892"/>
    <dbReference type="EnsemblBacteria" id="AYE35860">
        <property type="protein sequence ID" value="AYE35860"/>
        <property type="gene ID" value="CP523_11665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62167">
        <property type="protein sequence ID" value="QAS62167"/>
        <property type="gene ID" value="EI377_06485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="28801" checksum="4D9996282D77E91B" modified="2018-12-05" version="1">MRSERITLVENYIINHKTVSLDKLCEVFNVSKNTIRRDLSVLVKKGSIKKVYGGVTINENKELISFEERNVKNSNSKVLLCKAAVEFIKDGDTIFLDSGTTTVNIIEFLKDKKDITIFTNNVIAISKSIHYSNINIICLSGILNRKTKSFTGLHSTDILKSYNINKCFMSCTGISLERGVTNSTKEEFKIKKTAISRSSKCFLLADNSKFDKVSLMTFCEVEDLDCIITNSTPPEEYVKYFKDKKIILKICNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ14</accession>
    <name>A0A386PJ14_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06460</name>
        <name evidence="2" type="ORF">EI377_00940</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677436.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34139">
        <property type="protein sequence ID" value="AYE34139"/>
        <property type="gene ID" value="CP523_06460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59507">
        <property type="protein sequence ID" value="QAS59507"/>
        <property type="gene ID" value="EI377_00940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="29118" checksum="4300B52C946D8631" modified="2018-12-05" version="1">MSIDAKIIVILLGDIENDLLDKGEIKELYPIVLKSNDVVSYIKRKEIYINNLNIQVLNMFDFNLEKLKFCSEYIRGYDLVVVLSNIKTKDHEEILLNGIKEIKGKGKKLISIVNNRNENFIKNLSKICAVANVKSSSNDFSFLSYVLSKTIIHSYSNINTEGIIDYYITKTGKEEGLGRGIVNILTEYKNLQYYKRISFSIMSGNNITIEDEYQVFDVIKEYSRDDAYINKYIYQDNYFEDNWIISIISIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ63</accession>
    <name>A0A386PJ63_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">aspS</name>
        <name evidence="9" type="ORF">CP523_14240</name>
        <name evidence="10" type="ORF">EI377_09145</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678489.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00274"/>
    <dbReference type="EnsemblBacteria" id="AYE35497">
        <property type="protein sequence ID" value="AYE35497"/>
        <property type="gene ID" value="CP523_14240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60883">
        <property type="protein sequence ID" value="QAS60883"/>
        <property type="gene ID" value="EI377_09145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
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</entry>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="QAS60152.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="83" mass="9550" checksum="5560F67725D955CC" modified="2018-12-05" version="1">MKDYIQERVLEVAQYIIDSKDTIRKTAKVFGVSKSTIHKDMTERLPKINPVIAEQTHTILELNKAERHIRGGKATKLKYKAVD</sequence>
</entry>
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    <name>A0A386PJC4_CLOSE</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Eubacteriales</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35291">
        <property type="protein sequence ID" value="AYE35291"/>
        <property type="gene ID" value="CP523_13130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="64" mass="7487" checksum="4427073393621486" modified="2018-12-05" version="1">MSRYSNTSKVAKCGAVDSKYFRNTDKFEKDVQAKIDKTEEFKNKIRELILLDPNLIELKEEFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI4</accession>
    <name>A0A386PJI4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CidA/LrgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_13780</name>
        <name evidence="8" type="ORF">EI377_08670</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677144.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02066"/>
    <dbReference type="EnsemblBacteria" id="AYE35414">
        <property type="protein sequence ID" value="AYE35414"/>
        <property type="gene ID" value="CP523_13780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60802">
        <property type="protein sequence ID" value="QAS60802"/>
        <property type="gene ID" value="EI377_08670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="124" mass="13527" checksum="7673C5401299490A" modified="2018-12-05" version="1">MKLFRQSIIILGIYLLGELISKGLNLPVPGNIIGMLLLLLLLCTKVIKVENVETVSNFFLDHLAFFFIPAGVGLLTSFDSIKSSLIQIVLVCIIATTIVIVVTGLVVQFVSNKLNIKKNGSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ5</accession>
    <name>A0A386PJJ5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional folate synthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Dihydroneopterin aldolase</fullName>
                <shortName evidence="11">DHNA</shortName>
                <ecNumber evidence="11">4.1.2.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">7,8-dihydroneopterin aldolase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
                <ecNumber evidence="11">2.7.6.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
                <shortName evidence="11">PPPK</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
                <shortName evidence="11">HPPK</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">folK</name>
        <name evidence="13" type="ORF">CP523_13555</name>
        <name evidence="14" type="ORF">EI377_08455</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EC" id="2.7.6.3" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35371">
        <property type="protein sequence ID" value="AYE35371"/>
        <property type="gene ID" value="CP523_13555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60762">
        <property type="protein sequence ID" value="QAS60762"/>
        <property type="gene ID" value="EI377_08455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13555"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HPPK" evidence="12">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="275" mass="32085" checksum="2349811438CEDD80" modified="2018-12-05" version="1">MDKLYLENIEIFANHGVFQEEKNLGQKFIISLELKLDTREAAITGDLTKSVHYGELCHKIEEEFQKESYDLIETVAEKVAEFILFNYKLVKEVKVTLKKPWAPINRHLDYAAIEIVRGWHKAYIALGSNIGGKEHNIKEAINRIKENKNITVSKVSNLIETEPWGFEDQDTFINGVIEVETILSPKELIKTLLSIENDMKRERILRWGPRIIDLDIIFYDDLISNDEEVIIPHPRMEEREFVLEPLNEIAPNMLHPILNKRVFQLLRDIKKANLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJK0</accession>
    <name>A0A386PJK0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3298 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12160</name>
        <name evidence="3" type="ORF">EI377_06980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35108">
        <property type="protein sequence ID" value="AYE35108"/>
        <property type="gene ID" value="CP523_12160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60499">
        <property type="protein sequence ID" value="QAS60499"/>
        <property type="gene ID" value="EI377_06980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032774">
        <property type="entry name" value="WG_beta_rep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14903">
        <property type="entry name" value="WG_beta_rep"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="486"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="578" mass="65316" checksum="76A5249187E8E850" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL3</accession>
    <name>A0A386PJL3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsA</name>
        <name evidence="2" type="ORF">CP523_10555</name>
        <name evidence="3" type="ORF">EI377_05335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674184.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01390"/>
    <dbReference type="EnsemblBacteria" id="AYE34806">
        <property type="protein sequence ID" value="AYE34806"/>
        <property type="gene ID" value="CP523_10555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60200">
        <property type="protein sequence ID" value="QAS60200"/>
        <property type="gene ID" value="EI377_05335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="25"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="197"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="282"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="382" mass="42710" checksum="06D7212143036D8B" modified="2018-12-05" version="1">MINEANENSMKDLLNDFDVKRINKGDILEGRVIDVNDKEVTVNINYAFDGIISKEELTATFENPCDIVKQGDNIKVYVISPNDGEGYVLLSRIKALAISEKEDLIKAFKNKEAINIRIKEEVKGGLVGYYGSIRVFIPASLVSRERVELKQFIGKDLEVKLTEVDFKNRRVVASRRVIEEAIYEENKKKIWSSLKSGEKRNGVVKKILKVGAIVDIGGITGLIHINDLAWGRVNKVEDIVKVGDKVEVVIGEIDKSKERVSLILKDVNSDPWIVNTTGLKTGDILSGKVVKFLSFGAFVEIYPGVEGLVHLSEITEDNIAKPSDVLSIGQEVKVKVLDYNKENKKISLTIKDAEEKSKEYLKYNDSDEGVSLGDLFKGMFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR5</accession>
    <name>A0A386PJR5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15610</name>
        <name evidence="3" type="ORF">EI377_10325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678628.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35747">
        <property type="protein sequence ID" value="AYE35747"/>
        <property type="gene ID" value="CP523_15610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61084">
        <property type="protein sequence ID" value="QAS61084"/>
        <property type="gene ID" value="EI377_10325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="75" mass="8480" checksum="34C594A81C95F900" modified="2018-12-05" version="1">MKSDKIPKNFKDVFLSVRKIIALLVTIVFCYLSIVGKINSSEFIPIFSMIIGYYFGKSTALDNNASEKNNEKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK40</accession>
    <name>A0A386PK40_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09215</name>
        <name evidence="7" type="ORF">EI377_03960</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678331.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03055"/>
    <dbReference type="EnsemblBacteria" id="AYE34589">
        <property type="protein sequence ID" value="AYE34589"/>
        <property type="gene ID" value="CP523_09215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59989">
        <property type="protein sequence ID" value="QAS59989"/>
        <property type="gene ID" value="EI377_03960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09215"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="344" mass="40391" checksum="51168614B6A3012A" modified="2018-12-05" version="1">MSINKKPLFNEMGDIEISKKRIINGNTTNLNDFNNMKYSWVSEWYRQAMNNFWIPEEINLAQDLKDYNKLTEDERIAYDKILSFLIFLDSIQTANLSNINNYITASEVNLCLTIQAFQEAVHSQSYSYMLDTICSPEKRNEILYQWKDDKILLERNKFIGNLYNDFLENPTEGNLLRTIMANYILEGIYFYSGFMFFYNLERNGKMPGSAQEIRYINRDENTHLWLFRNILKELQEERPEIFTDSMKQELIDMMRTGVEHEIAWGHYVIGDNIQGLNKTLIDNYIKYLGNLRMKAIGFEDIYEGYNKNPAMWVDILADANSVKTDFFEAKSTAYAKAGALIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK76</accession>
    <name>A0A386PK76_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_09435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678046.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02745"/>
    <dbReference type="EnsemblBacteria" id="AYE34629">
        <property type="protein sequence ID" value="AYE34629"/>
        <property type="gene ID" value="CP523_09435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="132"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="187" mass="21857" checksum="6C250BB052F04210" modified="2018-12-05" version="1">MKKKELRNRVLEFRNDLSKEEKCKKDNKILRALLDSELYKNSNNIFVYINYGSEINTKEFINIAIKDRKKIFVPKIIKEIKEMKAVQITSLNNLMEDNYGILEPNSFEGSIEKDKLDLIIVPGVVFDLKGNRIGYGGGYYDRYLSEIKLNSNRVALAYELQIKNSIDVDEYDINVNYIITEDRIINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK91</accession>
    <name>A0A386PK91_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_15390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678749.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03068"/>
    <dbReference type="EnsemblBacteria" id="AYE35704">
        <property type="protein sequence ID" value="AYE35704"/>
        <property type="gene ID" value="CP523_15390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="69" mass="7527" checksum="1DD906F90E74A59D" modified="2018-12-05" version="1">MASNNNGSNRNLVPEAKAGLNRLKNEVASSIGLNNYEETDKGNLSSRQNGSVGGEMVKKMVEQYENQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL02</accession>
    <name>A0A386PL02_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35698">
        <property type="protein sequence ID" value="AYE35698"/>
        <property type="gene ID" value="CP523_15360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="114" mass="12655" checksum="B92FB08870B6124F" modified="2018-12-05" version="1">MISINGVKIAAPKTYEVTVQDLDGDTNRNANGGLIRDRIAVKRKLNLEWGPLTQSEISTLLSAVSSVFFTVTFPDPQLGMITKTMYVGDRTSPAYTWVDGKVKWSGLKMNFIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL22</accession>
    <name>A0A386PL22_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678709.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35728">
        <property type="protein sequence ID" value="AYE35728"/>
        <property type="gene ID" value="CP523_15515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="152" mass="18016" checksum="10FD912871AA87B8" modified="2018-12-05" version="1">MKNYLEENLFIKNQISNSQFVKVEVTDFHLINTNFNIKLKNIDFNKFDEVSVILKNIKTKEIYICNTNLNKNSLILELSSLNYLCSDNEYMVLILCKKDTYFEVLYPIFKDYSNNISTNYQISTYSKVSWYLRIIDTGEFRLSTILKSNYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLG8</accession>
    <name>A0A386PLG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_13015</name>
        <name evidence="12" type="ORF">EI377_07890</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677818.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02543"/>
    <dbReference type="EnsemblBacteria" id="AYE35269">
        <property type="protein sequence ID" value="AYE35269"/>
        <property type="gene ID" value="CP523_13015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60664">
        <property type="protein sequence ID" value="QAS60664"/>
        <property type="gene ID" value="EI377_07890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="322"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="396"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="686" mass="75635" checksum="F2AFE88740BD47A8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLI5</accession>
    <name>A0A386PLI5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13170</name>
        <name evidence="4" type="ORF">EI377_08015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02569"/>
    <dbReference type="EnsemblBacteria" id="AYE35299">
        <property type="protein sequence ID" value="AYE35299"/>
        <property type="gene ID" value="CP523_13170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60688">
        <property type="protein sequence ID" value="QAS60688"/>
        <property type="gene ID" value="EI377_08015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="2">
        <location>
            <begin position="89"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="144" mass="17062" checksum="6BEE8EF63EA77FED" modified="2018-12-05" version="1">MSLYKKTEAMLYNFNKTKAEIRNIELDLELLKSQYEGVGAIVYEERTGSTNKFNSSVENEVVIREKRIKKLENMKKLKEVEIMKIENSLTDLTNREKNLIQMRYFNKENNRMIAAKLDLTEEYVSELKRIIVNKISNILFLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLR2</accession>
    <name>A0A386PLR2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678630.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35746">
        <property type="protein sequence ID" value="AYE35746"/>
        <property type="gene ID" value="CP523_15605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="386"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="529" mass="62099" checksum="49637B88E621F1D7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLS1</accession>
    <name>A0A386PLS1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YunB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yunB</name>
        <name evidence="2" type="ORF">CP523_13990</name>
        <name evidence="3" type="ORF">EI377_08895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678633.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00215"/>
    <dbReference type="EnsemblBacteria" id="AYE35449">
        <property type="protein sequence ID" value="AYE35449"/>
        <property type="gene ID" value="CP523_13990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60837">
        <property type="protein sequence ID" value="QAS60837"/>
        <property type="gene ID" value="EI377_08895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014197">
        <property type="entry name" value="Sporulation_prot_YunB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09560">
        <property type="entry name" value="Spore_YunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021383">
        <property type="entry name" value="YunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02832">
        <property type="entry name" value="spo_yunB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="25051" checksum="EF55F41926174117" modified="2018-12-05" version="1">MNYYTKKSKKHIEIRHKKFIVVIIAIFFLFNSLLYFFGKSILPAVIKIAEMEMKREATDIINETALDIYSKEFNYDEAMIIEKDKEENITMVRADTVKLNALSSRLILESNRRLENLETLGVEIPIGYMTNNSVIHNLGPKINIKMEQVGNITSSYESVFESAGINQTRHKIYLNVKLNMRVIIPLNSQEIEIISQIPIAETIIVGKIPNTAIEFNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLX4</accession>
    <name>A0A386PLX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid-soluble spore protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Alpha/beta-type small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14530</name>
        <name evidence="5" type="ORF">EI377_09500</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678679.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00206"/>
    <dbReference type="EnsemblBacteria" id="AYE35549">
        <property type="protein sequence ID" value="AYE35549"/>
        <property type="gene ID" value="CP523_14530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60935">
        <property type="protein sequence ID" value="QAS60935"/>
        <property type="gene ID" value="EI377_09500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="83" mass="9403" checksum="5DB43D4FD1B31712" modified="2018-12-05" version="1">MSKTPLKKIIKSKLKSNKELSAAEILREKIKYEIADELGLKDKVDEYGWGSLTAEETGRIGGIMTKRKKELKIPTNDEILGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM07</accession>
    <name>A0A386PM07_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="7 8">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">murF</name>
        <name evidence="12" type="ORF">CP523_14870</name>
        <name evidence="13" type="ORF">EI377_09825</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="7 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676091.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01309"/>
    <dbReference type="EnsemblBacteria" id="AYE35609">
        <property type="protein sequence ID" value="AYE35609"/>
        <property type="gene ID" value="CP523_14870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60996">
        <property type="protein sequence ID" value="QAS60996"/>
        <property type="gene ID" value="EI377_09825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14870"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="112"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="318"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="454" mass="50936" checksum="02566D8726C3C9AC" modified="2018-12-05" version="1">MELNFLELLDAVEGELLVEKKEKSFNKLSTDTRKIEKDNIFLAIKGENFNGNKYVEEAMEKGASIAIVDEIHFDIKSLDGKITVIKVEDTLESLLKLASFYRKKLGVKVVAVTGSCGKTSTKDLIAGFLSYKYKVFKTKGNFNNQIGLPLMILELDSTIDVAVLEMGMSDLGEIHLLAETAKPDIAVITNIGLSHIENLKTQDNIMKAKLEVTDFFNKNNLLIVNGEDERLQNLSNRSFKVSKIGYNHEYDVYATNIILEENQTSFDAHIHGESHTFILEMPGKHNVLNAMLAIRVAKELEVSLEDMYKGIANIESTSMRLQVIKKDKITIINDCYNASPDSMKSSLDVLNMYNNSRRVAILGTMNELGEESETAHKNVGEYAIDKVDLLIAIGSYSQSFKNGFKGETIEIYDTKEEFLNNVQSIIKENDIILVKASRGMKFEDIVNSLEEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM80</accession>
    <name>A0A386PM80_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15680</name>
        <name evidence="3" type="ORF">EI377_10395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678606.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00555"/>
    <dbReference type="EnsemblBacteria" id="AYE35759">
        <property type="protein sequence ID" value="AYE35759"/>
        <property type="gene ID" value="CP523_15680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61098">
        <property type="protein sequence ID" value="QAS61098"/>
        <property type="gene ID" value="EI377_10395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="17"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="148" mass="16141" checksum="BDB52D5D74A92D1D" modified="2018-12-05" version="1">MNKLIAICTSEKKGTAKVMVNEVNVIEDFGIEGDAHAGKWHRQVSLLALEKIENFRSKGANVNFGAFGENLVVEGIELNKLPVGQRIKVGEVELEVTQIGKKCHDKCAIFYQVGQCIMPTNGIFTKVIKGGKIKVGDECILLDSGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2003-03-01" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q8G8K0</accession>
    <name>Q8G8K0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aerolysin family beta-barrel pore-forming toxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Alpha-toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04880</name>
        <name evidence="7" type="ORF">EI377_15395</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2004-11" db="EMBL/GenBank/DDBJ databases">
            <title>Alpha-toxin genes of Clostridium septicum isolates from China.</title>
            <authorList>
                <person name="Chen X."/>
                <person name="Guan F."/>
                <person name="Zhang C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2006" name="Vet. Microbiol." volume="114" first="51" last="59">
            <title>Genetic variation and cross-reactivity of Clostridium septicum alpha-toxin.</title>
            <authorList>
                <person name="Amimoto K."/>
                <person name="Sasaki Y."/>
                <person name="Fukuyama S."/>
                <person name="Tamura Y."/>
            </authorList>
            <dbReference type="PubMed" id="16337096"/>
            <dbReference type="DOI" id="10.1016/j.vetmic.2005.10.039"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="5">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerolysin family.</text>
    </comment>
    <dbReference type="EMBL" id="AY829447">
        <property type="protein sequence ID" value="AAV91345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB083437">
        <property type="protein sequence ID" value="BAC54149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB083438">
        <property type="protein sequence ID" value="BAC54150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB083439">
        <property type="protein sequence ID" value="BAC54151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675757.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q8G8K0"/>
    <dbReference type="STRING" id="1504.GCA_900092375_01699"/>
    <dbReference type="EnsemblBacteria" id="AYE33854">
        <property type="protein sequence ID" value="AYE33854"/>
        <property type="gene ID" value="CP523_04880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62000">
        <property type="protein sequence ID" value="QAS62000"/>
        <property type="gene ID" value="EI377_15395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005830">
        <property type="entry name" value="Aerolysn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01117">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00754">
        <property type="entry name" value="AEROLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00999">
        <property type="entry name" value="Aerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007712947" evidence="3">
        <location>
            <begin position="32"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAV91345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="BAC54149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="440" mass="49448" checksum="9EE38ACB7B5F6808" modified="2003-03-01" version="1">MSKKSFAKKVICTSMIAIQCAAVVPHVQAYALTNLEEGGYANHNNASSIKIFGYEDNEDLKAKIIQDPEFIRNWANVAHSLGFGWCGGTANPNVGQGFEFKREVGAGGKVSYLLSARYNPNDPYASGYRAKDRLSMKISNVRFVIDNDSIKLGTPKVKKLAPLNSASFDLINESKTESKLSKTFNYTTSKTVSKTDNFKFGEKIGVKTSFKVGLEAIADSKVETSFEFNAEQGWSNTNSTTETKQESTTYTATVSPQTKKRLFLDVLGSQIDIPYEGKIYMEYDIELMGFLRYTGNAREDHTEDRPTVKLKFGKNGMSAEEHLKDLYSHKNINGYSEWDWKWVDEKFGYLFKNSYDALTSRKLGGIIKGSFTNINGTKIVIREGKEIPLPDKKRRGKRSVDSLDARLQNEGIRIENIETQDVPGFRLNSITYNDKKIDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAS3</accession>
    <name>A0A386PAS3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioether cross-link-forming SCIFF peptide maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">scfB</name>
        <name evidence="8" type="ORF">CP523_00400</name>
        <name evidence="9" type="ORF">EI377_10890</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00591"/>
    <dbReference type="EnsemblBacteria" id="AYE33015">
        <property type="protein sequence ID" value="AYE33015"/>
        <property type="gene ID" value="CP523_00400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61184">
        <property type="protein sequence ID" value="QAS61184"/>
        <property type="gene ID" value="EI377_10890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024025">
        <property type="entry name" value="SCIFF_rSAM_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03974">
        <property type="entry name" value="rSAM_six_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="91"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="451" mass="52058" checksum="C2EA5F298F4656C8" modified="2018-12-05" version="1">MALIHKFKQGENFFILDVNTGAVHIVDELVYDLVDEDKMRNKEELIAEFSKKYGEDVISEAYDEIMELIDEDILYSKDQYEDIAHSSMDDRDYIKAVCLNIIHGCNLRCKYCFADEGEYNGNKGVMSLETAKKAIDYVVKRSGPRKNIEIDLFGGEPTMIMDTIKGIIKYARENEKSWKKNIRFTMTTNATLLNDDMMDFMDKEMGNIILSLDGRKCVNDNVRIKIDGSGSYDDIIPNIKKMIKKRTEGKTYYVRGTFTRANTDFYEDVMAMINEGFREISIEPVVLENGHPLALREEDLEEIFENYDKLYDEMSRRKKENNDVFNFYHFNISLNGGPCVYKRISGCGAGFEYVAITPQGDVYPCHQFVGKDEFKLGTIYDDTYNTSLGKEFKKAHIYNKPKCKECWARFYCSGGCQANNFNFNGDMKIPYEIGCKMQKKRIECAIALKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB69</accession>
    <name>A0A386PB69_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nifS</name>
        <name evidence="7" type="synonym">iscS</name>
        <name evidence="10" type="ORF">CP523_01185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02281"/>
    <dbReference type="EnsemblBacteria" id="AYE33165">
        <property type="protein sequence ID" value="AYE33165"/>
        <property type="gene ID" value="CP523_01185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01185"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="4"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="393" mass="43472" checksum="701C4C092C7D012F" modified="2018-12-05" version="1">MKTVYMDYAATTYVKPEVLDEMMPYFTEKFGNPSSFYGISRETKKAIDSGREKISKALNCDLNEVYFTGGGSEADNWAIKGIAWAHKNKGNHIITTKIEHHAVLHTCEYLEKNGFEVTYLDVNEEGFIDLEELKNAITDKTILVSIMFANNEIGTIQPIKEIGQICRERKVFFHTDAVQAVGNVKIDVKEMNIDLLSLAGHKIYGPKGIGVLYVRKGIKIDNLIHGGGQERARRAGTENIAAIVGLGKAIELATENLDEHAKKMTALRYKLIDGLLKVPHTRLNGPRGDKRLPGNVNVTFEFIEGESILLSLDFEGVCASSGSACTSGSLDPSHVLLAIGLPHELAHGSLRLTLGDGSTEEDVDYVIEVVPPIIERLRNMSPLWEDYLKKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB82</accession>
    <name>A0A386PB82_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00110</name>
        <name evidence="3" type="ORF">CP523_00305</name>
        <name evidence="4" type="ORF">EI377_10790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32964">
        <property type="protein sequence ID" value="AYE32964"/>
        <property type="gene ID" value="CP523_00110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33000">
        <property type="protein sequence ID" value="AYE33000"/>
        <property type="gene ID" value="CP523_00305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61168">
        <property type="protein sequence ID" value="QAS61168"/>
        <property type="gene ID" value="EI377_10790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00110"/>
    <dbReference type="KEGG" id="csep:CP523_00305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="202"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="30126" checksum="3D8CF928B5028E31" modified="2018-12-05" version="1">MSKIRFSKNEIDKLSKNKYVLKVSDKAITYTNEFKIHFIAEYSKGKTSKVIFEEAGFDVDVLGVRRIDCAGTRWRKAYKENGVLGLDDTRRNNSGRPRQRKITKDEIIAKQNAEIEYLMAEVELLKKLELHERQVKKGKLVAAQAFMLIKSIVNKLHLNNVIKQLCNVAGVSRSGYYNYLKSKKLGQSMSRRRNCWDNAPQESFFGHMKDEINYKSCSSLEELQLMIDDYIDYYNNERCQWNLKKLTPVKYRNQLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBL7</accession>
    <name>A0A386PBL7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02035</name>
        <name evidence="3" type="ORF">EI377_12555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678879.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00125"/>
    <dbReference type="EnsemblBacteria" id="AYE33325">
        <property type="protein sequence ID" value="AYE33325"/>
        <property type="gene ID" value="CP523_02035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61495">
        <property type="protein sequence ID" value="QAS61495"/>
        <property type="gene ID" value="EI377_12555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="365" mass="42289" checksum="2D60C12C091F7E81" modified="2018-12-05" version="1">MNDKVNLYRRNGKSVYIKQPSFKELAFVEYLWGHKETMADIGGVYSFKKDKWDMFYKKMVYPTDGKNFYCLIYTIDNVAIGEVSFHGYDSATKVARINIKIHIDYRGNGYGEEALRLLLEYYFLEFCGESLIDTITTKAAKKTFKKVGFEKFGRFREQTTYKVTKEMFLNSRIKKRRKVKVLAYDNMDIIEYMIPFKIFNKANEILKEELFEVTGVSYTGKSNLQYNISILSKVFNEDNEEKDILIIPGGATKEVCISNKIMMDYIFLNYNNCDYLLSFSTGIYFLLENHIIDGLSIPEIKEVKNELLENFGKDKIIKSNFVDNGKVVISSNIIGSIESCLNIINKVCGEEVYITLNKIFGIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBU2</accession>
    <name>A0A386PBU2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00345</name>
        <name evidence="2" type="ORF">EI377_10835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678136.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00579"/>
    <dbReference type="EnsemblBacteria" id="AYE33007">
        <property type="protein sequence ID" value="AYE33007"/>
        <property type="gene ID" value="CP523_00345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61175">
        <property type="protein sequence ID" value="QAS61175"/>
        <property type="gene ID" value="EI377_10835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="125" mass="15005" checksum="82FF0B2F2DDC5EB8" modified="2018-12-05" version="1">MFEFRDILIKQFFNFQVVRNIPGEMLIKFPNYIDCKFEKYNIILEEGIKLLKGIKSIQFDYSRNLIGINYNIKKMDSKILLYWIKIVIETLVDNSTFIEKNFNVDIDIIILKVKSDLLIKRNKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBX9</accession>
    <name>A0A386PBX9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02680</name>
        <name evidence="2" type="ORF">EI377_13205</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676944.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33445">
        <property type="protein sequence ID" value="AYE33445"/>
        <property type="gene ID" value="CP523_02680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61616">
        <property type="protein sequence ID" value="QAS61616"/>
        <property type="gene ID" value="EI377_13205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="94" mass="11071" checksum="DB530D161423F316" modified="2018-12-05" version="1">MNFLLNKIDTDLRKKVYEKTVNGIVHRKTEISIYKDSEKQKGKSFNEFVKKDKKSKKKITVKANKFVQPLIQVKAEKKDDFKVSEYGSFLDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBY7</accession>
    <name>A0A386PBY7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02735</name>
        <name evidence="6" type="ORF">EI377_13260</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676960.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00953"/>
    <dbReference type="EnsemblBacteria" id="AYE33455">
        <property type="protein sequence ID" value="AYE33455"/>
        <property type="gene ID" value="CP523_02735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61626">
        <property type="protein sequence ID" value="QAS61626"/>
        <property type="gene ID" value="EI377_13260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="13092" checksum="A6D49400B8C6456D" modified="2018-12-05" version="1">MSRVLIVDDAAFMRMMVKDILEKNGFEIIGEACNGIEAVDIYMKEKPDVVTMDITMPDMDGIEAVKAIKKFDPNAKVVMCSAMGQQSMVMDAIKAGAKDFIVKPFQADRVLEAITKVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC83</accession>
    <name>A0A386PC83_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">[FeFe] hydrogenase H-cluster maturation GTPase HydF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hydF</name>
        <name evidence="4" type="ORF">CP523_03265</name>
        <name evidence="5" type="ORF">EI377_13780</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02131"/>
    <dbReference type="EnsemblBacteria" id="AYE33555">
        <property type="protein sequence ID" value="AYE33555"/>
        <property type="gene ID" value="CP523_03265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61718">
        <property type="protein sequence ID" value="QAS61718"/>
        <property type="gene ID" value="EI377_13780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023873">
        <property type="entry name" value="FeFe-hyd_GTPase_HydF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041606">
        <property type="entry name" value="HydF_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040644">
        <property type="entry name" value="HydF_tetramer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18128">
        <property type="entry name" value="HydF_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18133">
        <property type="entry name" value="HydF_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03918">
        <property type="entry name" value="GTP_HydF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_dimer" evidence="2">
        <location>
            <begin position="176"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_tetramer" evidence="3">
        <location>
            <begin position="277"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="402" mass="45426" checksum="3F1E4741853EA7E3" modified="2018-12-05" version="1">MNNTPNSNRKHIAIYGKTNSGKSSLMNKLLGQEISLVSELEGTTTDPVSKAMELIPVGPVLFIDTAGLNDTTILGEMRVKRTLEILMRTDLALYIMDSNDLDFNSYKDMKLKFKKYNIPYITVINKIDTLSYEKLEEIKSNFEEAVFISTCENQGVEGLKELLIKKLQDDEREIPILGDLVPYNGKVILVVPIDSETPKGRIILPQVQCIRDCLDHGIKSYVVRDTELESALKDIKDVDLVITDSQIFKKVDRIVPKNIKLTSFSILFARHKGDINAFVEGASKVRNLKKNSKILISESCSHNISHEDIGRVKIPKMLNNYIGADLNYEYRVGHDFPENIEEYDLIIHCGACMINRKTVLNRVDLCKEKGIPITNYGVLIAYLTGILDRTIVVLEDSKKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC89</accession>
    <name>A0A386PC89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3785 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03370</name>
        <name evidence="2" type="ORF">EI377_13885</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679109.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00066"/>
    <dbReference type="EnsemblBacteria" id="AYE33573">
        <property type="protein sequence ID" value="AYE33573"/>
        <property type="gene ID" value="CP523_03370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61736">
        <property type="protein sequence ID" value="QAS61736"/>
        <property type="gene ID" value="EI377_13885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024210">
        <property type="entry name" value="DUF3785"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12653">
        <property type="entry name" value="DUF3785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="16387" checksum="02BA39823D1FD362" modified="2018-12-05" version="1">MTYKFNFEGKEYELKEDNLDYFANDEEFELEGIDEKKVLELLANSDDVDFDTAYYETCCEECRAGKEEKKKVFDFLEFFFYAYGKDGKFITSSIDDEYEKKSFTKLYREGKVDRSYLVTVIVCKNCGVYSIEIENFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCN0</accession>
    <name>A0A386PCN0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33237">
        <property type="protein sequence ID" value="AYE33237"/>
        <property type="gene ID" value="CP523_01550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="580" mass="67351" checksum="2717DE92A2F78B34" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCQ8</accession>
    <name>A0A386PCQ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biliverdin-producing heme oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04285</name>
        <name evidence="4" type="ORF">EI377_14810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00421"/>
    <dbReference type="EnsemblBacteria" id="AYE33745">
        <property type="protein sequence ID" value="AYE33745"/>
        <property type="gene ID" value="CP523_04285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61901">
        <property type="protein sequence ID" value="QAS61901"/>
        <property type="gene ID" value="EI377_14810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="PTHR10720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000343-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="23858" checksum="21C01A673FD18C9A" modified="2018-12-05" version="1">MKFMMDIREKTSLLHSAAENTGYIKKLVDGNASVEGYAEYIYNLEKMYKAIEDALDKNEGNNVVNPFVTKELYRSELIRKDLDFLLGDKLKSMKLLASTEACISKIEELSKTKPELLVAYAYTRFLADLFGGRTFLSLLSTNYKISNEGLNYYQFADINDLRGYVMKYHNMLAEINLSDDLKVDFINEVNNAYIYNLAISNELDAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD24</accession>
    <name>A0A386PD24_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33885">
        <property type="protein sequence ID" value="AYE33885"/>
        <property type="gene ID" value="CP523_05045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="47"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="614" mass="73093" checksum="E736055A8E367935" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD82</accession>
    <name>A0A386PD82_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome C551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01805</name>
        <name evidence="3" type="ORF">EI377_12325</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677305.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02390"/>
    <dbReference type="EnsemblBacteria" id="AYE33284">
        <property type="protein sequence ID" value="AYE33284"/>
        <property type="gene ID" value="CP523_01805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61455">
        <property type="protein sequence ID" value="QAS61455"/>
        <property type="gene ID" value="EI377_12325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="51" mass="6102" checksum="419874EE51BDBAEA" modified="2018-12-05" version="1">MEDKKIICKDCGNEFVFTVGEQEFYKEKGFDNEPVRCVDCRRARKAQNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD83</accession>
    <name>A0A386PD83_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673894.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00439"/>
    <dbReference type="EnsemblBacteria" id="AYE33437">
        <property type="protein sequence ID" value="AYE33437"/>
        <property type="gene ID" value="CP523_02640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="403" mass="47768" checksum="752691816A0E181D" modified="2018-12-05" version="1">MKKQLKPSFYNDFKCVADKCEIICCENWNIFIDKKTYKKYMNLKGDIKKDIKQNIKINKEHESTWDYALVKLNNEKRCSLLNEQGLCRIHAELGEDMLSHTCKVYPRQNVKVGDIYEYNLSISCPEVAKKALLGKEKFSFILEEDYISKKEEIEMGYVNLDEYCANLLWEVRKFSIEIIQMRDIELWKRIVLLGLFCKEVDENLSDVNKFIDEIEKYRFMTSNEDILNSLNNIKINNDKKLNLLTQFVRSRINFVVNNDVFIEVCNDLDSALGFGEEKSEEKIIENYTNIENGIYKKFLVDNSHILENYLVNTIYREFILFYAEKSFYNRFVKVIIQYSIARFLLMGQLATKKESFNNNDIIKVFYSYSRVIEHNPVFIDNLIAGLKQKGYDELNYMSILIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDF3</accession>
    <name>A0A386PDF3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mac-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675011.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01875"/>
    <dbReference type="EnsemblBacteria" id="AYE34025">
        <property type="protein sequence ID" value="AYE34025"/>
        <property type="gene ID" value="CP523_05860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015117">
        <property type="entry name" value="IdeS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09028">
        <property type="entry name" value="Mac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017177361" description="Mac-1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Mac-1" evidence="2">
        <location>
            <begin position="118"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="420" mass="48048" checksum="41993D5CC55B3DBB" modified="2018-12-05" version="1">MIKKTKIISAILLAGILSLIIPKTLTTYADSSALNYDFKYDLNNDSIINELDIDEISKHYNNQKDSADWTEKFDFNNDGIIDIFDIIKISKCNGIKKPEKKLSKNALELQNLLAANKNITTTEDAAGKKIYNVWVKGITPPTEDDFTNLDLGSNYTLKVAPWKPGQGWYDINKTKNGSGDDFLCSGAVAANMLHWWLDQNKEYVDRYLAQNPENGKNLNKTLDIRTSSTFHDQKNSDIFNLIKNCFRNKSLWANSTLVWYINGFSMDFPIGPQYTSPHFDARVGFLRDIFKERGLTDVSYIGSYDLFNIRLLEWLQEDKALGIVHRTLASYDHIITLWGASFDENGNIIGIYVTDSDDENYEISNNVLYGMKYFRIIKDSNGVARMTTYTGKDNNIGAKLVDLYSLSLEKDQWEKYFNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDH1</accession>
    <name>A0A386PDH1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS91 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00005</name>
        <name evidence="3" type="ORF">CP523_01870</name>
        <name evidence="4" type="ORF">CP523_02995</name>
        <name evidence="5" type="ORF">CP523_03120</name>
        <name evidence="6" type="ORF">CP523_03885</name>
        <name evidence="7" type="ORF">CP523_03970</name>
        <name evidence="8" type="ORF">CP523_06635</name>
        <name evidence="9" type="ORF">CP523_06645</name>
        <name evidence="10" type="ORF">CP523_08960</name>
        <name evidence="11" type="ORF">CP523_09165</name>
        <name evidence="12" type="ORF">CP523_10200</name>
        <name evidence="13" type="ORF">CP523_12710</name>
        <name evidence="14" type="ORF">CP523_14145</name>
        <name evidence="15" type="ORF">CP523_15595</name>
    </gene>
    <organism evidence="5 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32943">
        <property type="protein sequence ID" value="AYE32943"/>
        <property type="gene ID" value="CP523_00005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33296">
        <property type="protein sequence ID" value="AYE33296"/>
        <property type="gene ID" value="CP523_01870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33504">
        <property type="protein sequence ID" value="AYE33504"/>
        <property type="gene ID" value="CP523_02995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33527">
        <property type="protein sequence ID" value="AYE33527"/>
        <property type="gene ID" value="CP523_03120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33669">
        <property type="protein sequence ID" value="AYE33669"/>
        <property type="gene ID" value="CP523_03885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33685">
        <property type="protein sequence ID" value="AYE33685"/>
        <property type="gene ID" value="CP523_03970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34173">
        <property type="protein sequence ID" value="AYE34173"/>
        <property type="gene ID" value="CP523_06635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34175">
        <property type="protein sequence ID" value="AYE34175"/>
        <property type="gene ID" value="CP523_06645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34538">
        <property type="protein sequence ID" value="AYE34538"/>
        <property type="gene ID" value="CP523_08960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34579">
        <property type="protein sequence ID" value="AYE34579"/>
        <property type="gene ID" value="CP523_09165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34746">
        <property type="protein sequence ID" value="AYE34746"/>
        <property type="gene ID" value="CP523_10200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35213">
        <property type="protein sequence ID" value="AYE35213"/>
        <property type="gene ID" value="CP523_12710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35478">
        <property type="protein sequence ID" value="AYE35478"/>
        <property type="gene ID" value="CP523_14145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35744">
        <property type="protein sequence ID" value="AYE35744"/>
        <property type="gene ID" value="CP523_15595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00005"/>
    <dbReference type="KEGG" id="csep:CP523_01870"/>
    <dbReference type="KEGG" id="csep:CP523_02995"/>
    <dbReference type="KEGG" id="csep:CP523_03120"/>
    <dbReference type="KEGG" id="csep:CP523_03885"/>
    <dbReference type="KEGG" id="csep:CP523_03970"/>
    <dbReference type="KEGG" id="csep:CP523_06635"/>
    <dbReference type="KEGG" id="csep:CP523_06645"/>
    <dbReference type="KEGG" id="csep:CP523_08960"/>
    <dbReference type="KEGG" id="csep:CP523_09165"/>
    <dbReference type="KEGG" id="csep:CP523_10200"/>
    <dbReference type="KEGG" id="csep:CP523_12710"/>
    <dbReference type="KEGG" id="csep:CP523_14145"/>
    <dbReference type="KEGG" id="csep:CP523_15595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE35744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="409" mass="48597" checksum="18791D5E498BC523" modified="2018-12-05" version="1">MKKGKIKRILEDHWKEFEKLYKNKIRPNVKKEVEKVLKCKDTKYGFIELKCNNCNTTKRIGFTCKSRFCTSCGKIYTDNWIDNMLGNLINVRHRHIVFTIPKELREFFGLDRQRLKILPKCAARAVTSWMHSLNRKEEFTPGIVTVIHTFGRDLKWNPHVHMMVTEGGRGNITEWRHIRHISYESLRKRWQKVLLDEITYINGNTKEIKLLKNKLYKEKDKGFYVHAKTEIKSAKTAAKYVGRYVGRPAIAESRILKYDGENVTYKYTRHEDNKVIVETVHVYEFIKRIIRHIPEKNFKMIRYFGIYSRRSKGKFNFIKMIDEKILSIRRSIATWENRILAISGVNPCKCPNCGNKMRFHDIVYPKYGSMRERLRIKIIEENEEKLEKAIENYAITKRILSGKIIPKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDW3</accession>
    <name>A0A386PDW3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00633"/>
    <dbReference type="EnsemblBacteria" id="AYE33038">
        <property type="protein sequence ID" value="AYE33038"/>
        <property type="gene ID" value="CP523_00520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="89"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="494" mass="56317" checksum="6C7890D71A2579B2" modified="2018-12-05" version="1">MHCNIMKKMVFIYLILIVIIANLLLFFKINAFFVFNISLLLAMLIYYFANNSDSEEIIIDKGKENNINRTTFKNSILKLNETGKSIFISHKSLKNISNRVKESSEVILGLTEENNGSVNNLDNSCKDIKNKIDIMDNLLKEAKNSSKLSEKTIEEQNNILNNVEKKVQTLKEYYKEVLSTCIELTNSFDKIYAFTSNINDIASQTNLLSLNASIEAARAGEDGKGFAVVAKEIKNLSELSKTFSFNINEQLNLMKNELDKLNKNSRETDNVIIETSKSVNILNNSFLDIINNNSSLKEKITSIKSNSVEILKMSDEIEKISNDLKGSHCITLNSVESVVKDIEDQVDILDGFQVITEELIENCNTLIDISIRKDIESKLKDICMSIYTTELKKDNISLKSFANKIGANDIFYVNKDGYFEFTSENRKNKFNLFEVNKEAKGFFNSNEIYKIYPLSKREDTGETNLYMHIKRKDKPGIVSIEMPINTLFKMSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDX4</accession>
    <name>A0A386PDX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01547"/>
    <dbReference type="EnsemblBacteria" id="AYE33667">
        <property type="protein sequence ID" value="AYE33667"/>
        <property type="gene ID" value="CP523_03875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="358" mass="41827" checksum="DF4647D25D3CB09F" modified="2018-12-05" version="1">MVFDRQTFDFPIVLGFTVSLISLFIALSLFKTNFDFFNDTNIYWNKKVSLNIKMKHKINSNSFYDKLNEGKIYYLNQDEIYKRDIKNINYIKGIHDTDLSEIIPLYSGEYLNEEEINSEEKIVVIGKYLEKDTYKKNEKTYIDIHNEKYEVKGLIGRKSDSKYSIYIFMPSRTYNKAFNGEESDSYIIEVDKETNKEIIDKINNIFKDEISDINIDYKKLNKPIVKAFRLQKNILTDLSVAIIFSIVCSITFVLLWFMKISKNISIRKALGANGNDIFIFVFKNLIQMLTISIIIASVLSYGLLNIVMKYITTLEISINIYVIFQSILILILILIIILMSVILLKKFSKMKISNLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDZ8</accession>
    <name>A0A386PDZ8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00725</name>
        <name evidence="4" type="ORF">EI377_11220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674646.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02375"/>
    <dbReference type="EnsemblBacteria" id="AYE33078">
        <property type="protein sequence ID" value="AYE33078"/>
        <property type="gene ID" value="CP523_00725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61247">
        <property type="protein sequence ID" value="QAS61247"/>
        <property type="gene ID" value="EI377_11220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="29500" checksum="92E475F7CDFD9BEF" modified="2018-12-05" version="1">MFKFFKNNKEEIKNIEIDKNNIPKHIAIIMDGNGRWAKARKLPRTMGHKAGVETIRRVLKEAHKLDIKYLTLYAFSTENWKRPQEEVGALMKLLVEYLRSELKELNENGVVIKILGDISKLQKEVREEVENAINLTKNNKGVVMNIAFNYGGRDEIIRATKLVSEDVKKGILKSEDITEEVFEKYLYTKNIPDPDLIIRPSGEQRISNFLLWQCAYSEFWYSDICWPDFKEEHLHKAIYDYQNRDRRYGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE81</accession>
    <name>A0A386PE81_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_07745</name>
        <name evidence="8" type="ORF">EI377_02440</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34335">
        <property type="protein sequence ID" value="AYE34335"/>
        <property type="gene ID" value="CP523_07745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59732">
        <property type="protein sequence ID" value="QAS59732"/>
        <property type="gene ID" value="EI377_02440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="59"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="253" mass="28861" checksum="2CBF0883506111C6" modified="2018-12-05" version="1">MRKSLLKDNKYMFISIIILLILWQMGAVAVNNQLLFPSLDRITDELHRIILNKDFINLIFASLLRCLISFIISIILAIILGTLSYINKFIYNFLYPIFSVIKSIPTMAFIVLALIWISKDYAPIMIGGLISIPIYYEVVLNSLLGIDENIIEMCEVYRVKNKDIIISIYLPTIIFGLINVFSSSLSLIFKVVISGEIYSQPKYGIGAIIQMEKMQLNTVAVIAWIIIISIITILFDKVIKKLSSRCIKWNKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE87</accession>
    <name>A0A386PE87_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">panB</name>
        <name evidence="9" type="ORF">CP523_07825</name>
        <name evidence="10" type="ORF">EI377_02515</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02102"/>
    <dbReference type="EnsemblBacteria" id="AYE34343">
        <property type="protein sequence ID" value="AYE34343"/>
        <property type="gene ID" value="CP523_07825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59739">
        <property type="protein sequence ID" value="QAS59739"/>
        <property type="gene ID" value="EI377_02515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07825"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="5 7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7 8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="275" mass="29872" checksum="D64EA476A8B1E5D8" modified="2018-12-05" version="1">MKNTAITFKAAKQNNEKLTMLTAYDYSTAKIIDEAGINGILVGDSLGMVCLGYEDTLSVTMEDIIHHTKAVSRGVKNTLVVADMPFMSYQTSVYDAVVNAGRLIKEGRAHVVKLEGGIEVCDKIEGIVKASIPVMAHIGLTPQSINALGGFKVQGKNEDAARELIEAAKTVERAGAFAVVLECVPAKLAEIITKELSIPTIGIGAGDKCDGQILVYQDMLGMFNDFTPKFVKKYANVGEIMNGAFKKYINEVRDGVFPEEVHSFKISDEVIEKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC1</accession>
    <name>A0A386PEC1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06565</name>
        <name evidence="8" type="ORF">EI377_01055</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677469.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02190"/>
    <dbReference type="EnsemblBacteria" id="AYE34160">
        <property type="protein sequence ID" value="AYE34160"/>
        <property type="gene ID" value="CP523_06565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59528">
        <property type="protein sequence ID" value="QAS59528"/>
        <property type="gene ID" value="EI377_01055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
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        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="764" mass="89208" checksum="7BA056D0C8664CDA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEG2</accession>
    <name>A0A386PEG2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chemotaxis protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02560</name>
        <name evidence="8" type="ORF">EI377_13095</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673928.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00455"/>
    <dbReference type="EnsemblBacteria" id="AYE33421">
        <property type="protein sequence ID" value="AYE33421"/>
        <property type="gene ID" value="CP523_02560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61595">
        <property type="protein sequence ID" value="QAS61595"/>
        <property type="gene ID" value="EI377_13095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="124"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="247" mass="28063" checksum="06CCB3EC99858D90" modified="2018-12-05" version="1">MARRNKKIKVNDEPTGNEWLATYSDCITLLLTFFILLYSMSSVDNQKMQRLSNAFQTLMNGEKGNTIMEYDMYNGEVPLIGGEADIEVNVDEAARTEQQKMYIDVKKFVEENDLSSVVEIVDSERGVVIQLRDNILFETSSSSLREDSKGILDKINSLIASMDNPIIVEGHTDNRPIHTTEFPSNWELSADRAVNVVRYFVEAKGENPKRFTAAGYGEYRPVAPNDSYDNLAKNRRVNILIMSKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK4</accession>
    <name>A0A386PEK4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis protein CheW</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Purine-binding chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02765</name>
        <name evidence="3" type="ORF">EI377_13290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676971.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00959"/>
    <dbReference type="EnsemblBacteria" id="AYE33461">
        <property type="protein sequence ID" value="AYE33461"/>
        <property type="gene ID" value="CP523_02765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61632">
        <property type="protein sequence ID" value="QAS61632"/>
        <property type="gene ID" value="EI377_13290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="151" mass="17164" checksum="6F8FE4A8B7745FC9" modified="2018-12-05" version="1">MDEMKILIFNLGKEFYATDISEVERILGSEKTTKLPDSPSFLEGVIDYEEGILPVINLVKRFNKSLEDNFNLEDKKIIVVKKEFGKIGILVDNVSEVLSIGKDEVNNPKTVSSLVSKEYMRGFIRKNDNIVIMLDLDKILSTEEEAMLFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM0</accession>
    <name>A0A386PEM0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 3">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpt</name>
        <name evidence="5" type="ORF">CP523_08625</name>
        <name evidence="6" type="ORF">EI377_03375</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674897.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01666"/>
    <dbReference type="EnsemblBacteria" id="AYE34483">
        <property type="protein sequence ID" value="AYE34483"/>
        <property type="gene ID" value="CP523_08625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59885">
        <property type="protein sequence ID" value="QAS59885"/>
        <property type="gene ID" value="EI377_03375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08625"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="178" mass="20007" checksum="1D5FD6D67B5D4C4D" modified="2018-12-05" version="1">MLEDIKEVLLTENEIMQRIKEIASKISEEYKGKDLLVVGILKGSVIVASDLIKNITIPCSIDFMALSSYGNSTETSGVVRILKDLDHGIEGKDVIIVEDIIDSGVTLDYLLKYLKARKANSIEIVTLLSKPARRKVEIDVKYCGFEVPDEFLVGYGLDFSEKYRNLPFIGILKEEVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM1</accession>
    <name>A0A386PEM1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore photoproduct lyase</fullName>
            <ecNumber evidence="3">4.1.99.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">splB</name>
        <name evidence="2" type="ORF">CP523_04015</name>
        <name evidence="3" type="ORF">EI377_14535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.99.14" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676929.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02783"/>
    <dbReference type="EnsemblBacteria" id="AYE33694">
        <property type="protein sequence ID" value="AYE33694"/>
        <property type="gene ID" value="CP523_04015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61849">
        <property type="protein sequence ID" value="QAS61849"/>
        <property type="gene ID" value="EI377_14535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003913">
        <property type="term" value="F:DNA photolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023897">
        <property type="entry name" value="Spore_PP_lysase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034559">
        <property type="entry name" value="Spore_PP_lysase_Clostridia"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00412">
        <property type="entry name" value="spore_photoproduct_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04070">
        <property type="entry name" value="photo_TT_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="73"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="335" mass="39032" checksum="1367B98E3165DD86" modified="2018-12-05" version="1">MFIPDKVVFDEKALKYQLGIELLNRFKKENIEVQINKSGRVIGSNKETDREKYFNGKRTLVVGVKGDTKFQSCKPSAHYQLPLVSGCMGMCEYCYLNTQLGKRPYIKVYVDIDEILNKAFKYAEERLPEVTVFEGSATSDPIPVEDYTHGLKKAIEAFGANENTRFRFVSKFKEVDEFLKLNHNGHTTIRFSINTNEIIRKYEHGTDSIDERIEAAKKIKKAGYKLGFIIAPVFMYDGWKEEYGELLEKIKNEFRGEKVEFEVISHRFTERAKNNILSIYPNSTLPMDVNDRKFKFGQFGYGKYVYKNEELQEMKEFFKKSLVGAFDEKNIKYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP1</accession>
    <name>A0A386PEP1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoVR family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04115</name>
        <name evidence="2" type="ORF">EI377_14635</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676885.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02762"/>
    <dbReference type="EnsemblBacteria" id="AYE33714">
        <property type="protein sequence ID" value="AYE33714"/>
        <property type="gene ID" value="CP523_04115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61869">
        <property type="protein sequence ID" value="QAS61869"/>
        <property type="gene ID" value="EI377_14635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="455" mass="53763" checksum="F0EFB9C024C76A80" modified="2018-12-05" version="1">MEYSLKDLEVWNETIEKKAIEVGLNFYPQEFEIIGFNEMLGYEAYVGMPSKYPHWSYGKAYDKNKTLYSLNMTGLPYEMVINSNPCLAYLMRENTLLLQILTMAHVYGHNDFFANNRLFIEGTKAKNSLEMFKLDAEIIRGYINNPNIGYERVEKILDAAHAIKFQIPRVIGVKELTQEEIRENIIGDYNNEIENRSILDKNKEIPMPDISKVPLEPCDDVMGFIIKYSGLEEWEKSILKIVKRETKYFMPQIETKIMNEGWASFWHYNILKELDLDEGLYFEFLKRHNDVVAPVIGGLNPYYIGFRIFEDIEKRYGREKIFEVRQLERDNSFLRKYLTQELCEELNLFQFAKRSFEFVIDEVSDEEGWKTIRDNLASNCGVGSIPYIRVIELNKKDYSLTLEHSFDGRELEISYAKETLKYIYDLWKHRVVLRTKTKDGKEIEIICDDRRVFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES3</accession>
    <name>A0A386PES3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01190</name>
        <name evidence="2" type="ORF">EI377_11690</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674383.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02280"/>
    <dbReference type="EnsemblBacteria" id="AYE33166">
        <property type="protein sequence ID" value="AYE33166"/>
        <property type="gene ID" value="CP523_01190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61336">
        <property type="protein sequence ID" value="QAS61336"/>
        <property type="gene ID" value="EI377_11690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="150" mass="16776" checksum="075646FDF910853B" modified="2018-12-05" version="1">MKLSTKGRYGVKAMVDLAIHYGNAPVSIKVISQRQNISEYYLEQLFSPLRKAGLIKSIRGAQGGYVLNKAPSEIKVADVMDVLEGPIEIADCIEGAECNNIDCCATRLLWKKIKSSIDEVMENITLQDIVNDYTNIKNKNDEIKLLKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET0</accession>
    <name>A0A386PET0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 14">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">hemB</name>
        <name evidence="16" type="ORF">CP523_03190</name>
        <name evidence="17" type="ORF">EI377_13705</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677260.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02145"/>
    <dbReference type="EnsemblBacteria" id="AYE33541">
        <property type="protein sequence ID" value="AYE33541"/>
        <property type="gene ID" value="CP523_03190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61704">
        <property type="protein sequence ID" value="QAS61704"/>
        <property type="gene ID" value="EI377_13705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03190"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="322" mass="36119" checksum="A5EBFF7196CD1FB9" modified="2018-12-05" version="1">MIKRGRRLRANAAIRDLVRENTLTSNDLIFPIFVVEGENRKEEIKSLEGNYHWSLDRLDEVIKDVENLGIKGVIVFGLPEHKDECGSEAYSDEGIVQKAVKKIREISEKLYVITDVCMCQYTSHGHCGILEGNNIDNDLTLEKLGEIALSHARAGAHMVAPSDMMDGRVAYIRNILDKNNYENVAIMSYSAKYCSAFYGPFREAAHSAPQFGDRKTYQMDPSNGIEALREIEMDIDEGADIIMIKPAMSYLDIVRATKDRINLPICAYNVSGEFAMVKAAAKAGLIDEKGITLEMLLSMKRAGADMIITYYALEAAKWLKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF15</accession>
    <name>A0A386PF15_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03630</name>
        <name evidence="7" type="ORF">EI377_14160</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677723.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02219"/>
    <dbReference type="EnsemblBacteria" id="AYE33621">
        <property type="protein sequence ID" value="AYE33621"/>
        <property type="gene ID" value="CP523_03630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61785">
        <property type="protein sequence ID" value="QAS61785"/>
        <property type="gene ID" value="EI377_14160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="107"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="446"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="574" mass="63265" checksum="23EC39A1864F39F7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF40</accession>
    <name>A0A386PF40_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676721.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34675">
        <property type="protein sequence ID" value="AYE34675"/>
        <property type="gene ID" value="CP523_09695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017454766" evidence="1">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="123" mass="13259" checksum="2CFE3FCBBFE79832" modified="2018-12-05" version="1">MKLKKMIFTGALVLSISVPGIATFAQTASDSGHWLDNNTKISASLSGEDGVATAITTKIIARSGDSMEAGLQYYDGNNEYFYLGGNYSSYRASYTGGNRHARGFDSIHTSTKTESMYALHITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF52</accession>
    <name>A0A386PF52_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09685</name>
        <name evidence="4" type="ORF">EI377_04465</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676718.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34673">
        <property type="protein sequence ID" value="AYE34673"/>
        <property type="gene ID" value="CP523_09685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60073">
        <property type="protein sequence ID" value="QAS60073"/>
        <property type="gene ID" value="EI377_04465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="195" mass="22766" checksum="0325B2569700DD64" modified="2018-12-05" version="1">MNETKELILKNTIELISKKGDATIREIAEKAKVNVASINYHFGNKNNLLKEVESYFSETLYRVQNNVLENPNLDAEEKIIQWALELMEFMFKYPSIVSLISKLVNEENAYSPAILDKVYMNSEIIEKLSMLIAIVTNISDEKIIQFKYLQIFSGILGPVLNELLFTIYRKENSLSMRNENIREEYIRYLVRTNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD1</accession>
    <name>A0A386PFD1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 4</fullName>
            <shortName evidence="6">EF-4</shortName>
            <ecNumber evidence="6">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lepA</name>
        <name evidence="8" type="ORF">CP523_02300</name>
        <name evidence="9" type="ORF">EI377_12820</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674005.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00507"/>
    <dbReference type="EnsemblBacteria" id="AYE33376">
        <property type="protein sequence ID" value="AYE33376"/>
        <property type="gene ID" value="CP523_02300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61546">
        <property type="protein sequence ID" value="QAS61546"/>
        <property type="gene ID" value="EI377_12820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="601" mass="67093" checksum="9938FA86F3FD9AD5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG0</accession>
    <name>A0A386PFG0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06675</name>
        <name evidence="3" type="ORF">EI377_01140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679218.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34177">
        <property type="protein sequence ID" value="AYE34177"/>
        <property type="gene ID" value="CP523_06675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59540">
        <property type="protein sequence ID" value="QAS59540"/>
        <property type="gene ID" value="EI377_01140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="69" mass="7320" checksum="FBAADB90B05A5A97" modified="2018-12-05" version="1">MLEKLSLSDEEYDYLAKCIAIGVGIGTFVGSLIGNVILGFAAGGVIGIVVSGIRFLSHKLKGMHRKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ1</accession>
    <name>A0A386PFJ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_01795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02392"/>
    <dbReference type="EnsemblBacteria" id="AYE33282">
        <property type="protein sequence ID" value="AYE33282"/>
        <property type="gene ID" value="CP523_01795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010141">
        <property type="entry name" value="FGAM_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01857">
        <property type="entry name" value="FGAM-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="5">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="439"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1248" mass="139021" checksum="1E580B93E3D3CF07" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM1</accession>
    <name>A0A386PFM1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">glpK</name>
        <name evidence="9" type="ORF">CP523_05960</name>
        <name evidence="10" type="ORF">EI377_00440</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer and homodimer (in equilibrium).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675056.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01894"/>
    <dbReference type="EnsemblBacteria" id="AYE34044">
        <property type="protein sequence ID" value="AYE34044"/>
        <property type="gene ID" value="CP523_05960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59416">
        <property type="protein sequence ID" value="QAS59416"/>
        <property type="gene ID" value="EI377_00440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05960"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="261"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="411"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="498" mass="55640" checksum="826D4BF2FCF5C7B0" modified="2018-12-05" version="1">MKKYIVALDQGTTSSRAIIFDNEQNILGVSQKEITQIYPKEGWVEHNPMEIWASQYGVLQEVMAKTNIDQEEIAAIGITNQRETTIVWDKNTGEPIYNAIVWQCRRTAEICDKLKEENGLSEYVNEATGLIIDAYFSGTKIKWILDNVEGAREKAERGDLLFGTVDTWLVWKLTGGKVHITDYTNASRTMLYNINKLEWDEKILKTLDIPKSMLPEVRNCSEIYGYTNLGGKGGYRVPIAGIAGDQQAALFGQACFEKGSAKNTYGTGCFLLMNTGEEKVTSKNGLLTTIAIGLSGKVQYALEGSVFVGGAVIQWVRDELMLVNDAQDTEYFAKKVNNNGGVYIVPAFVGLGAPHWDMYARGAIFGLTRGSNRNHIIRAALESIAYQSKDVLHAMEEDAGYRIESLKVDGGASKNEFLMQFQSDIINTEVTRPIITETTALGAAYLAGLAVGYWKDKEEIAKSWYVSQKFEPNIDAKERERLYTGWKKAVSRVKNWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ3</accession>
    <name>A0A386PFQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4342 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02180</name>
        <name evidence="4" type="ORF">EI377_12700</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00531"/>
    <dbReference type="EnsemblBacteria" id="AYE33352">
        <property type="protein sequence ID" value="AYE33352"/>
        <property type="gene ID" value="CP523_02180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61522">
        <property type="protein sequence ID" value="QAS61522"/>
        <property type="gene ID" value="EI377_12700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025642">
        <property type="entry name" value="DUF4342"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14242">
        <property type="entry name" value="DUF4342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4342" evidence="2">
        <location>
            <begin position="60"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="205" mass="22853" checksum="DC674E145C6B5386" modified="2018-12-05" version="1">MMGITLEKVDKVKERTGATYAEAKYALEVNNGDILDAIIYLEEIKGNNSEVLKTLPNIENSEKSSETVDELKVWLKDLINKGNITRIRIYKEEKEIIDVPVNAGIAAGVIAVIVPQILAFGLIAAVATQIRIELTMSDGTVEVVNKYVSKAVDDIKDVATEMASKVKNKVSGVKHDTLRQNREKNKLYDSDEKVYSYTVNFDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ8</accession>
    <name>A0A386PFQ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09440</name>
        <name evidence="3" type="ORF">EI377_04180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678051.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02746"/>
    <dbReference type="EnsemblBacteria" id="AYE34630">
        <property type="protein sequence ID" value="AYE34630"/>
        <property type="gene ID" value="CP523_09440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60029">
        <property type="protein sequence ID" value="QAS60029"/>
        <property type="gene ID" value="EI377_04180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="815" mass="92327" checksum="7A5D77143C938A76" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR1</accession>
    <name>A0A386PFR1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyphosphate polymerase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">VTC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07290</name>
        <name evidence="3" type="ORF">EI377_02040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673753.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01075"/>
    <dbReference type="EnsemblBacteria" id="AYE34267">
        <property type="protein sequence ID" value="AYE34267"/>
        <property type="gene ID" value="CP523_07290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59673">
        <property type="protein sequence ID" value="QAS59673"/>
        <property type="gene ID" value="EI377_02040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VTC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="29354" checksum="7FF14393342BBEF7" modified="2018-12-05" version="1">MAQKTFRRYELKFIVNKEAFQRITAELPKYMNLDKHCSDMGTYMIHNIYFDTPDDEIIQKSLAKPYYKEKLRLRSYTNPIRMEDKVFLELKKKIGGIVNKRRATMTYQEAINFIRKREYPKNCSYLDEQVLKEIEVFLNRYSVEAKAYLSYKRIAYYGKEDREFRVTFDENILTRREKVNFTSGDYGMELLNNKYLMEVKIIGAIPLWLAKLLSELKVYRGGFSKYGEEYKRYLKQKDNILQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT5</accession>
    <name>A0A386PFT5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-channel forming cytolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11160</name>
        <name evidence="6" type="ORF">EI377_05950</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aerolysin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677058.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PFT5"/>
    <dbReference type="EnsemblBacteria" id="AYE34925">
        <property type="protein sequence ID" value="AYE34925"/>
        <property type="gene ID" value="CP523_11160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60319">
        <property type="protein sequence ID" value="QAS60319"/>
        <property type="gene ID" value="EI377_05950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051715">
        <property type="term" value="P:cytolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003963">
        <property type="entry name" value="Bi-component_toxin_staph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016183">
        <property type="entry name" value="Leukocidin/Hemolysin_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036435">
        <property type="entry name" value="Leukocidin/porin_MspA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07968">
        <property type="entry name" value="Leukocidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01468">
        <property type="entry name" value="BICOMPNTOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56959">
        <property type="entry name" value="SSF56959"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01002">
        <property type="entry name" value="hlyII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362711" evidence="3">
        <location>
            <begin position="30"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Leukocidin" evidence="4">
        <location>
            <begin position="62"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="316" mass="35251" checksum="6E37EC87FE957DE5" modified="2018-12-05" version="1">MVKKIGVIILATITLLGMSSPFTCKVVKAAENTCVMESNGDGVNKFTYSDTAYADYNRFKTNLNVTFIEDSHTNQLTALVSTEGSFIPSGLTKVGGYYDAQMYWPSVYRTIVESYDSQNKVKIARSIPTNQINTVSVSETMGYTIGGSLSVEASKEGPKAGAELNGSYTAERSVTYDQPDYRTLLKSDSTNRAEWQVVFNANKDGYDRDSYHGIYGNQLFMRYRLYNKGIDNLTTDNNLSPLISGGFSPEVVVALKAPKGTKTSAITVKYTRFSDEYKLNWSGTEWYGTNNKLNKLDNSSETFVLDWENHTVEHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT7</accession>
    <name>A0A386PFT7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_11100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE34913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00920"/>
    <dbReference type="EnsemblBacteria" id="AYE34913">
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        <property type="gene ID" value="CP523_11100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="228"/>
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    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="234" mass="27184" checksum="C01F83C5C61A4D83" modified="2018-12-05" version="1">MNNKILVIEDDTFINDILSTSLKTEGYIIKSAFTAKEAKDLLESFTPDLTLLDVNLPDESGFDLCKFINLSYSIPIIMLTARTDVVDKVLGLELGADDYITKPFHIKEVLTRIKIALRRVEKYKNNSDISYTNLNSHIKINYNSRLVLKDDIEIPLKPKEYELLEFLSQNRNRVFSREELLDNVWEFTYEGDTRTIDIHVRRLRSKLDVSTEKSIIETVFGVGYVIRSYYENKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ7</accession>
    <name>A0A386PFZ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05290</name>
        <name evidence="3" type="ORF">EI377_15850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676272.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33931">
        <property type="protein sequence ID" value="AYE33931"/>
        <property type="gene ID" value="CP523_05290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62082">
        <property type="protein sequence ID" value="QAS62082"/>
        <property type="gene ID" value="EI377_15850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025912">
        <property type="entry name" value="YrvL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14184">
        <property type="entry name" value="YrvL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="15899" checksum="9CFC9B7251B5AAAD" modified="2018-12-05" version="1">MKKEHKLKDLIIFAIFSSLLLLIIFLISFFCGGTLMLLFGLKYSSIKVLIKFFIIYFVVDLIIDNILEPLATAIKEVKDLSDIQYNILYFFMDVPIQILILGLISSSISGIHMPVLTIILFSIAYYFIGYFLNKKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG18</accession>
    <name>A0A386PG18_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_03600</name>
        <name evidence="12" type="ORF">EI377_14130</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677728.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02225"/>
    <dbReference type="EnsemblBacteria" id="AYE33616">
        <property type="protein sequence ID" value="AYE33616"/>
        <property type="gene ID" value="CP523_03600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61780">
        <property type="protein sequence ID" value="QAS61780"/>
        <property type="gene ID" value="EI377_14130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="398"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="684" mass="76827" checksum="BF933A5B3D966685" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG98</accession>
    <name>A0A386PG98_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1667 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05945</name>
        <name evidence="2" type="ORF">EI377_00425</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675049.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01891"/>
    <dbReference type="EnsemblBacteria" id="AYE34041">
        <property type="protein sequence ID" value="AYE34041"/>
        <property type="gene ID" value="CP523_05945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59413">
        <property type="protein sequence ID" value="QAS59413"/>
        <property type="gene ID" value="EI377_00425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="117" mass="12557" checksum="4E9B5D9D57F94E22" modified="2018-12-05" version="1">MIKELICISCPMGCHLKVDTEKKTVEGNTCKRGEVYGLNEVTNPVRVVTSTVKVEGGELPVMPVKTSGAIPKNLNFECMKAINSIIVKAPVKMGDIIIENVLGTGIDVIASRNISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC7</accession>
    <name>A0A386PGC7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03480</name>
        <name evidence="3" type="ORF">EI377_14005</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677905.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02247"/>
    <dbReference type="EnsemblBacteria" id="AYE33592">
        <property type="protein sequence ID" value="AYE33592"/>
        <property type="gene ID" value="CP523_03480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61756">
        <property type="protein sequence ID" value="QAS61756"/>
        <property type="gene ID" value="EI377_14005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362753" evidence="1">
        <location>
            <begin position="30"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="440" mass="48505" checksum="EA2A0E343EDA8C5F" modified="2018-12-05" version="1">MKKLKLLSTVLLATAVAMTSFVGCGNSGGKDSGKDKPVEITWWNFPNFEVKDGQVGKYEEELIKSFEEKNPDIKVNVEMISFNGGGEKLNAAIASNSAPDILYDAPGRIIDFARQGVLAPVDDMIKALNGDVSDELLAGCKLEDTYYMYPFNTTTFMMAANKTMFEEAGLLDLLPLKKEDRLWTIEEFEAALKGIKEAKPDVIPMAFFSKSTAGDQGTRAFVSNLYGGSVMNNDQTSYTFDEEPAVKSMEWVKKSIESGLIGSGSEALASNDAIDLFLQQKSAFTILYSTGLKKNNADKKIGDFEEVLLPIPSPSKDKLALEALIGGLCVFNNGDDAKIEASKKFIDFLANDPDWQKKNLVATGTFSVRDSIKGLYDEEEMKFAEGMGKYTAEYYNTVNGFAEMRTHWFPALQEITLGQTPAKEALKNFNDKANETLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF1</accession>
    <name>A0A386PGF1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Two-component sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12290</name>
        <name evidence="5" type="ORF">EI377_07115</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03014"/>
    <dbReference type="EnsemblBacteria" id="AYE35133">
        <property type="protein sequence ID" value="AYE35133"/>
        <property type="gene ID" value="CP523_12290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60525">
        <property type="protein sequence ID" value="QAS60525"/>
        <property type="gene ID" value="EI377_07115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="290"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="383" mass="43952" checksum="5381872EC41156E1" modified="2018-12-05" version="1">MIKSKELLLMRYISFCILTFELFTESESNRIIKLVFILLFIINNNLRIFYLEKDSYFNMSLIIELVIIPIAQLIFGGTIIFYLIGVSIDLFTLKNKIFRYIVGIIILILGIYPEFSIKAQLGIINFVLLGMLFILLRYISRLYSTKVKAQNLYDKLRVSEEKLIEANKELEVYLQSVEELTLLKERNRISREIHDSVGHTLSTALIQLSAMEAIADKESSSIKGMASNLRGFINESFQDVKRAVRELKPDEYENYQGVLRLQEVCKNFERMSGVEVKVVISKSNWNLTSKQSNHLYRIIQEVLSNSLKHGKATVVKVIMNFTDDEFIISFSDNGVGTDKIVESGVGLKSIKERVEELDGIIDMKSKINAGFFIKVIIPKEVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF8</accession>
    <name>A0A386PGF8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIN domain nuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PIN/TRAM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_08845</name>
        <name evidence="5" type="ORF">EI377_03600</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02709"/>
    <dbReference type="EnsemblBacteria" id="AYE34517">
        <property type="protein sequence ID" value="AYE34517"/>
        <property type="gene ID" value="CP523_08845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59919">
        <property type="protein sequence ID" value="QAS59919"/>
        <property type="gene ID" value="EI377_03600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08845"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="295"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="361" mass="40032" checksum="C7007A7053E953B4" modified="2018-12-05" version="1">MFKKTIRIIFSLIGSICGYVVGSIVLDIPQINKINFLSQPVGSVLFLIFTVLLFGLILFLISPRIYDWVSNLIEYAEKNIQKLSATEILYGGFGALLSLIITSLIGMPLNKLTIVGPILFILFNLIFAFIVGDIFIKKKEDISALLINLKKTSIKEKKSKNVLKTIPKVLDTSVIIDGRIFDICKTGFVEGPLVIPSFVLDELRHISDSSDSLKRNRGRRGLDILNKIQKELEIETQIWEGDFQEIAEVDSKLLKLAQVLKGKVITNDFNLNKVAEFQGVPVLNINELANAIKPVVLPGEEMRVIVVKDGKEATQGIAYLDDGTMIVVEGGKKYIGEPIDVLVTSVLQTAAGRMIFAKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL4</accession>
    <name>A0A386PGL4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsM</name>
        <name evidence="11" type="ORF">CP523_09105</name>
        <name evidence="12" type="ORF">EI377_03850</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678380.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00259"/>
    <dbReference type="EnsemblBacteria" id="AYE34567">
        <property type="protein sequence ID" value="AYE34567"/>
        <property type="gene ID" value="CP523_09105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59967">
        <property type="protein sequence ID" value="QAS59967"/>
        <property type="gene ID" value="EI377_03850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="121" mass="13610" checksum="6E1F19FE7C0A2563" modified="2018-12-05" version="1">MARISGVDLPREKRVEIGLTYIYGIGLSTSHKILAATGVNPDTRVKDLTEEEVTAIREYVKTLTIEGDLRREVALNIKRLVEVGCYRGIRHRKGLPVRGQKTKTNARTRKGPKKTIANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR1</accession>
    <name>A0A386PGR1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">lysA</name>
        <name evidence="6" type="ORF">CP523_06080</name>
        <name evidence="7" type="ORF">EI377_00560</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675114.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01917"/>
    <dbReference type="EnsemblBacteria" id="AYE34068">
        <property type="protein sequence ID" value="AYE34068"/>
        <property type="gene ID" value="CP523_06080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59439">
        <property type="protein sequence ID" value="QAS59439"/>
        <property type="gene ID" value="EI377_00560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06080"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="33"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="40"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="430" mass="47832" checksum="B34275913320EA89" modified="2018-12-05" version="1">MKLFGAMEIKENELCIGGMKASELVKNYGTPLYVIDEKLIRDNCREYIKSFKCKENGNRVAYAGKAFLTVEMCKLINEEGLYLDVVSGGELYTAYKAEYPLDNIYFHGNNKTLEEIEMGVKLGAGRFIIDNLWELEKVNEIAEKYKKIQKVYLRLTPGIEAHTHDYIKTGQIDSKFGFAPIGDNILNAVKSALAFDNIALVGLHCHIGSQIFDTEPFGDAAEIMLKFIDNIRQETGHIISELDLGGGFGIYYSEGDKPKKTSEYCKVILDRVDKVCNELNLDKPILTIEPGRSIVANAGTTLYTIGSIKEVPGIRKYVAVDGGMTDNIRPALYQAKYEAVLANKITESDEEVVTIAGKCCESGDILIKDIKLPFVYSGDILGIMSTGAYGFSMSNNYNKNLRPAVVFVKDGEGRIVSKRQSYKDLIDSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY8</accession>
    <name>A0A386PGY8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11845</name>
        <name evidence="3" type="ORF">EI377_06665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673427.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35050">
        <property type="protein sequence ID" value="AYE35050"/>
        <property type="gene ID" value="CP523_11845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60443">
        <property type="protein sequence ID" value="QAS60443"/>
        <property type="gene ID" value="EI377_06665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11845"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="70" mass="7889" checksum="06C54AE7C9631D0A" modified="2018-12-05" version="1">MIQFKKDELLKDTPEYENYSDNEVALSIEEMKELGMLSCGGCCQKKGENGKKSCCKNKKSDKNSGCCRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA8</accession>
    <name>A0A386PHA8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">CP523_14180</name>
        <name evidence="7" type="ORF">EI377_09085</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678518.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00286"/>
    <dbReference type="EnsemblBacteria" id="AYE35485">
        <property type="protein sequence ID" value="AYE35485"/>
        <property type="gene ID" value="CP523_14180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60871">
        <property type="protein sequence ID" value="QAS60871"/>
        <property type="gene ID" value="EI377_09085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14180"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="15"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="256"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="380" mass="43401" checksum="8024766DA72A18D2" modified="2018-12-05" version="1">MSKKRYTLLKKDGEARRGRFETPHGTIETPVFMNVGTCAVIKGAVSTMDLKEIGCQVELSNTYHLHLRPSDKVVANLGGLHQFMNWDRPILTDSGGFQVFSLSGMRKIKEEGVYFSSHIDGRKIFMGPEESMQIQSNLASTIAMAFDECIPNPSTREYVEKSVARTTRWLERCKNEMDRLNSLDNTINKEQMLFGINQGGCYEDIRIEHAKTITKMDLDGYAIGGLAVGETHEEMYRIIEAVVPHLPEDKPIYLMGVGTPENILEAVDRGVDFFDCVLPARNGRHGHVFTKNGKINLMNAKFELDTRPIDEGCQCPACKSYTRAYIRHLFKAKEMLAMRLCVLHNLYFYNKLMEEIRNAIDGEYFKEFKEQKLKEWNTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD3</accession>
    <name>A0A386PHD3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09240</name>
        <name evidence="4" type="ORF">EI377_03985</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678322.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03050"/>
    <dbReference type="EnsemblBacteria" id="AYE34594">
        <property type="protein sequence ID" value="AYE34594"/>
        <property type="gene ID" value="CP523_09240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59994">
        <property type="protein sequence ID" value="QAS59994"/>
        <property type="gene ID" value="EI377_03985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="387" mass="44411" checksum="3D4833DB7DA450AC" modified="2018-12-05" version="1">MEKKLKKAYEKALSLYNNGELNKALKCCEDGISNDLKNSDLLNLKGLILYVKGDLKGAVSIWKINKACNSDIMSDSYIKDSIEDKRRLELFQKAQKLIKNLHIDEAIELLELCLESDFNSIQVNNSLSICYLKRGEVDKCRLYLNKALSIDKTDKVSLSILKDLGIYKDVKEPKYRKVITFVIILAIILGGASVFVFKNLNKSKENIAENVGKQEEQQEKVEEKTEEKPEEKLQKNIENEKLDKVEDNSEKQNDGVIAEEVPLTLDEVGNFYIDATTKFGEGNYQVAKELLNKAIKYSDKSYLNDDILFLLASTEEKLGNVDNSIKNFEKYISLYENGDYIEETCYKLALLYKDKDKEKSKIYAYKLVYNHPESIYNNDNIDSILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG7</accession>
    <name>A0A386PHG7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 125 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Metal-independent alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05790</name>
        <name evidence="2" type="ORF">EI377_00275</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674966.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01858"/>
    <dbReference type="EnsemblBacteria" id="AYE34012">
        <property type="protein sequence ID" value="AYE34012"/>
        <property type="gene ID" value="CP523_05790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59384">
        <property type="protein sequence ID" value="QAS59384"/>
        <property type="gene ID" value="EI377_00275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="428" mass="49636" checksum="9280A3D13CB637AD" modified="2018-12-05" version="1">MNSTTTTKLENIKETLIKIGQDLSNSIKDEKLKSLFYNCFINTIETTVTVEDKDTFVITGDIPAMWLRDSTSQVEHYLPFVKENENLKDLFTGLINRQMKCILIDPYANAFNKEANGQKWDNDITKDSPWVWERKYEIDSLCYPVRLIYKYWKGSGDTSFFNDEIKNVFNIIIDLWTTEQDHFGKSDYSFQRLNCSETDTLCNKGLGNPVSYTGMTWSGFRPSDDACKYGYLIPANMFASVVLKYIEEIAETIYNDYSLKEKALNLRNEIENGIEKYGIIENEEFGKIYAYETDGLGNYNFMDDANVPSLLSIPYIEFRNIDDEIYQNTRKFILSKNNPFYYEGTAASGIGSPHTPPEYIWHIALSMAGLTTNNKDEILSLLNTLINTDGDTRFMHEGFYCNNPKEFTRDWFAWSNSLFAYFIYEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ6</accession>
    <name>A0A386PHJ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09580</name>
        <name evidence="2" type="ORF">EI377_04325</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676681.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02622"/>
    <dbReference type="EnsemblBacteria" id="AYE34654">
        <property type="protein sequence ID" value="AYE34654"/>
        <property type="gene ID" value="CP523_09580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60053">
        <property type="protein sequence ID" value="QAS60053"/>
        <property type="gene ID" value="EI377_04325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="143" mass="16202" checksum="495CBD2E5ED3CAF7" modified="2018-12-05" version="1">MLVEKTRELYDKKYDLNCAECILKAANECYDLNLSNQTIKAMAAFGGGMAIESVCGGATGAIAAIGIMFTEERGHKSPHVKIMTSEFMNMFKDNLGTLNCDELKLKYRENEDDRCLYMMLVAAKTLEQVVEKYKNEYEIIRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS5</accession>
    <name>A0A386PHS5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14995</name>
        <name evidence="3" type="ORF">EI377_09950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676044.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35633">
        <property type="protein sequence ID" value="AYE35633"/>
        <property type="gene ID" value="CP523_14995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61020">
        <property type="protein sequence ID" value="QAS61020"/>
        <property type="gene ID" value="EI377_09950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="116" mass="14111" checksum="C828A335EBE2017A" modified="2018-12-05" version="1">MKKRFYLTNIIVLITIMQVGYLWVHTFKAQEEDIEVFKEVKEVKSIKEIESNLERLKNYSIEEYFKEKDGWIITLKLSGIENILYNLNNLNKFYIKNYDFYYENYNAMLNLTLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT4</accession>
    <name>A0A386PHT4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S41 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06475</name>
        <name evidence="7" type="ORF">EI377_00955</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677440.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02172"/>
    <dbReference type="EnsemblBacteria" id="AYE34142">
        <property type="protein sequence ID" value="AYE34142"/>
        <property type="gene ID" value="CP523_06475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59510">
        <property type="protein sequence ID" value="QAS59510"/>
        <property type="gene ID" value="EI377_00955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="419" mass="45853" checksum="10007DE3128F2EF3" modified="2018-12-05" version="1">MEDFNKRDEKKKGGKRVIVIISLVIAFIASNLGFFYLGNRFAFNGFTLRGINSEVTEDLKDIQDISKYNLLFQVRNALLSKYDGEIDDNKLLEAAIKGMTISLKDPYTVFMNSDEYKSFMEQSEGHFVGIGAQLGVKDGKVTVVAPIEGSPAEKAGLKTGDVILKVDDKDVSESNVEKTIAMIKGEEGKAVKLTLSRESGEPFDVNIVREVVKTIAVKGEMIDDSVGYIQIVSFDEDVSEAFKKKLVELKEKGMKGLILDLRGNPGGFLGESVKIASQFIPKGETVTYTIDKYDNKSESKSIGGEAEGMPLVVLINGGSASASEVVTGALRDYGVATTVGENSFGKGVVQQLVEFKNGKGGLKVTTSKYYTPNGENIHKVGIKPDIEVKISEELLKQPYDRNNDPQFDKALEVIKEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU4</accession>
    <name>A0A386PHU4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage head morphogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03106"/>
    <dbReference type="EnsemblBacteria" id="AYE35685">
        <property type="protein sequence ID" value="AYE35685"/>
        <property type="gene ID" value="CP523_15295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006528">
        <property type="entry name" value="Phage_head_morphogenesis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032721">
        <property type="entry name" value="Toxin-deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04233">
        <property type="entry name" value="Phage_Mu_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14424">
        <property type="entry name" value="Toxin-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01641">
        <property type="entry name" value="phageSPP1_gp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_Mu_F" evidence="1">
        <location>
            <begin position="198"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="574" mass="67704" checksum="FF673C0ECA3527D3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV4</accession>
    <name>A0A386PHV4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein subunit beta/FixA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09565</name>
        <name evidence="4" type="ORF">EI377_04310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676678.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02619"/>
    <dbReference type="EnsemblBacteria" id="AYE34651">
        <property type="protein sequence ID" value="AYE34651"/>
        <property type="gene ID" value="CP523_09565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60050">
        <property type="protein sequence ID" value="QAS60050"/>
        <property type="gene ID" value="EI377_04310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="259" mass="28116" checksum="BD9FF967BE858736" modified="2018-12-05" version="1">MNIVVCLKQVPDTTAVKIDPKTGTLIRDGVPSIINPEDKHALEAALRIKETSGANVTVISMGPPQAQSALREALCMGADEAILITDRAFAGADTLATSKALAGALKRLEYDVVFAGRQAIDGDTAQVGPEIAEHLHIPQVTYVQDVKVENDGLLINRALEDGYELIKVQTPVLLTAIKELNEPRYMNVEYIFNTANKEIKIWSADDIEVNKAELGLKGSPTKVKKSMTKETKGAGEVVKETAPEAVKYVLGKLKEKHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX1</accession>
    <name>A0A386PHX1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxalate:formate antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11335</name>
        <name evidence="4" type="ORF">EI377_06155</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673249.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02824"/>
    <dbReference type="EnsemblBacteria" id="AYE34957">
        <property type="protein sequence ID" value="AYE34957"/>
        <property type="gene ID" value="CP523_11335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60352">
        <property type="protein sequence ID" value="QAS60352"/>
        <property type="gene ID" value="EI377_06155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00090">
        <property type="entry name" value="NITROGENASE_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="2">
        <location>
            <begin position="36"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="436" mass="48875" checksum="E65ECB0FF9A409F5" modified="2018-12-05" version="1">MINSVEIINKLSKLSDIDNIKDVKSLTSASFPGPHCPLFGSALLLKEIKDAVFVVIGTDECSYYTKQMTMRSEMYGGIDGRCVSIILSQHDVTFGCQKKIEVAFKELIEDYNPKAVFLITTCVVELIGDDVESLGDVLGEEYGIPVVTVHTEHFKSENHIIGLERTLSSCIGIMEKQIRSEKVSVNIIGQRSGKFEESELGKILIESNIDINLMLPGCNVEDIRKAPQAHINIVTNSIGLPLARKMKSKFKIPYILFEKFTNPESILSTYKNLFDTLELELPNEITELYKKANDIVEYGKEVLNGAKYIYGNTPLQCFEVNAFMTKLGMIPQLIQVSYMTEEDNQYINSILNTTNPYVCKSANIAPLQGIYDVLKPDLYLGHEYATRLAKKGIAIVRSDMASAMVGMEVVLFFVDELIRAYKEAKEYQGGIVNEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI06</accession>
    <name>A0A386PI06_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage shock protein A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10540</name>
        <name evidence="4" type="ORF">EI377_05325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674187.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01392"/>
    <dbReference type="EnsemblBacteria" id="AYE34804">
        <property type="protein sequence ID" value="AYE34804"/>
        <property type="gene ID" value="CP523_10540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60199">
        <property type="protein sequence ID" value="QAS60199"/>
        <property type="gene ID" value="EI377_05325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="24583" checksum="9788EC5739080989" modified="2018-12-05" version="1">MGIFNRMSNMFKSKVNSTLDELENPIELLDQKIRDMENQLNKAKLNSAQIIGNAHEIKRKLEATELEVNDLESKVKLALSKGNEDLAKRALAKKIETEKKYKSLKETYEAARNQADSIKKNLSELENEIIKTRSYRDEAAARFSNAEASKKVNEVLANVQTKSNSIKIDDIERKIQKQEALAKGLGELKNTDTFESEFEALDSVDLDLELEKYKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI17</accession>
    <name>A0A386PI17_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15540</name>
        <name evidence="3" type="ORF">EI377_10250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678699.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35733">
        <property type="protein sequence ID" value="AYE35733"/>
        <property type="gene ID" value="CP523_15540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61072">
        <property type="protein sequence ID" value="QAS61072"/>
        <property type="gene ID" value="EI377_10250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="339" mass="40207" checksum="BFB92CD63A43A0DE" modified="2018-12-05" version="1">MRRYLNKSLFYQGDSNILPLLLVCYTGIFFILNLLINDWFICIPSQVLYTTNYKYLKLIVDTDIIIILYLYIFMVYSISVGMFKRKKWATLLSGPFTKKDVRRRELLIVIISTIIFFIMYFLIVWKGYIRNYELISYLNNFKNLIAIDLIKMISLSLFIIGVLFLLDSIFSNLYFLIFSVVFLGIYGLSFLYNTNMIISGLKVDYRQHIFNFVNEFLFNNNYYDLNIRRILLVLGIISVMGIVFLIISSVLTNKIKVENMTESIMFEFPKIIGRFMAYTFIGLILSPIIINFINYYIFYYELTWGMEITFRILLIVVLSIISYLFIQKLKRKRKSGLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI26</accession>
    <name>A0A386PI26_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Yae1_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15590</name>
        <name evidence="3" type="ORF">EI377_10305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678687.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35743">
        <property type="protein sequence ID" value="AYE35743"/>
        <property type="gene ID" value="CP523_15590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61082">
        <property type="protein sequence ID" value="QAS61082"/>
        <property type="gene ID" value="EI377_10305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Yae1_N" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="182" mass="20027" checksum="5AFF2D3C35812D89" modified="2018-12-05" version="1">MCEYNYSNNECNNIGVVSSNNAGLSNDCRNAYRMGYNRGFCCGNEQGYKAGYEDGKKEGCEKGYAKGLKDGCERGYAKGLRDGAECAYKKGYEKGYRDGSQKGYQKGYEDGREAGVREGFQRGKAYGCREGYKKGYKDGYLAGLNAAQNNGCEDTSNCGDDFDFEDNTCSSSSGRWNENDCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI35</accession>
    <name>A0A386PI35_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mobA</name>
        <name evidence="6" type="ORF">CP523_15645</name>
        <name evidence="7" type="ORF">EI377_10360</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678619.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00562"/>
    <dbReference type="EnsemblBacteria" id="AYE35753">
        <property type="protein sequence ID" value="AYE35753"/>
        <property type="gene ID" value="CP523_15645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61091">
        <property type="protein sequence ID" value="QAS61091"/>
        <property type="gene ID" value="EI377_10360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="186" mass="21659" checksum="545237C0B4F49152" modified="2018-12-05" version="1">MIDKTLAILAGGKSSRMNYNNKAFLKYREKTFIENIIEKGKDYKEIIIIANNKEIYKEFNLRVVEDIYKEQGPLSGIHSALENSKTKYCLCVACDMPLLSRELLKRLGEEDSDFDILIPKVNNRLQPLCAVYSKDIVNILKENLKHKNNKLQKIILNLNYKIIKGLEEKNFTNVNTIQEYKELEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB5</accession>
    <name>A0A386PIB5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00938"/>
    <dbReference type="EnsemblBacteria" id="AYE34894">
        <property type="protein sequence ID" value="AYE34894"/>
        <property type="gene ID" value="CP523_11005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="500" mass="57058" checksum="3FA1BFD75F323E91" modified="2018-12-05" version="1">MLLYLKGDLVMTIFNNDKKSFYLNPLINKLIITLFFISLLLIPFDDLPYFNALGGLGKRASIYPFLLMVPIIILVFFQNRKIFYKNCIENNLIFAFYISCIISVLFNITVIHSSVFKGQTGIKRAIIQIGSISLLLLSMYAIQFIINKNKLSIITIRKFICLSFIPVAIIGMLQLLNLLKIYDFSYIIQKSSYFINNSLRGDLYGTRIRGVSAEASYLGMYCAFLFPWFFSYILTEKKKISKVIFSVISFIILALVVATKSRTATILIFVDLFVILVLILLFYKSIRVKIFSSFMIVLMGIFLFGFSSSMDYLINRPKAHQNNSQHSSNTVNNYQVGQLISSISDNNIDSNIARKSMQKAAFKIGLDNPVLGVGIGQFGFHLNNYLDKDAFNNSHEVRVWSNNEVSTWPPVHSLYHRIFAEEGSVGLLLYLLFIIIICLKLFIKIITNKNNLFGIILLSSYGTILIGQLTLDQFVIPQFWIMTSIIILYNNDLITLQESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB6</accession>
    <name>A0A386PIB6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hslO</name>
        <name evidence="7" type="ORF">CP523_14540</name>
        <name evidence="8" type="ORF">EI377_09510</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678678.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00204"/>
    <dbReference type="EnsemblBacteria" id="AYE35550">
        <property type="protein sequence ID" value="AYE35550"/>
        <property type="gene ID" value="CP523_14540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60936">
        <property type="protein sequence ID" value="QAS60936"/>
        <property type="gene ID" value="EI377_09510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="32226" checksum="7A6BC227A6DB2493" modified="2018-12-05" version="1">MDKIIRATAKDGMVRIIAGETTNLVNEGSKIHECTPVASAALGRMLTAGALMGITLKSEKEVMSLKINGGGEAKGITVTAYEGAKVKGFIGNPYGNLPLNEKGKLDVGGYIGKDGDFIVIKDLGMKDPYVGQVPILTGEIGEDLAYYFTVSEQTPSAVSLGVLVDRDLSIKVAGGFIIQMMPNADELLADLITYRLEEIPSITKMLEEHGDIKKVLEFIFEGMDLKILEEIEPKYTCNCSRERVERALISIGEKELSEIYNDGKEEELKCHFCNKSYKFTSEEIGDLLEKIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID5</accession>
    <name>A0A386PID5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11105</name>
        <name evidence="2" type="ORF">EI377_05895</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677076.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00919"/>
    <dbReference type="EnsemblBacteria" id="AYE34914">
        <property type="protein sequence ID" value="AYE34914"/>
        <property type="gene ID" value="CP523_11105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60308">
        <property type="protein sequence ID" value="QAS60308"/>
        <property type="gene ID" value="EI377_05895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="659" mass="74789" checksum="7CAD663DDFC76205" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL2</accession>
    <name>A0A386PIL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675178.1">
        <property type="nucleotide sequence ID" value="NZ_CP023671.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35217">
        <property type="protein sequence ID" value="AYE35217"/>
        <property type="gene ID" value="CP523_12730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="252" mass="30013" checksum="F894C44FE75A59B2" modified="2018-12-05" version="1">MIKVTLLPILIYKYSTIPDSIIIEDDILIYKKPYQENGSVLLDIVLYDLNKNEHKTLETVTNIPNENIGNLSMDNGLIVWNKLFELPSTEFPKYNFSYENYNIYTYDIKSELKDSFKIDDECFYYSPYIFNNKIALVKIFKDHFFYSEIAIYDLNNKNIDSVINQNTIPNKDYIENIKGNPEMNKDFLIWSQDCYGNNLVYDIKRKEFIEIIPNDFLYEKQYYINPYKLWGNKVYIKGVIDDKPINSIYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR2</accession>
    <name>A0A386PIR2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10340</name>
        <name evidence="3" type="ORF">EI377_05120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34768">
        <property type="protein sequence ID" value="AYE34768"/>
        <property type="gene ID" value="CP523_10340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60167">
        <property type="protein sequence ID" value="QAS60167"/>
        <property type="gene ID" value="EI377_05120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="82" mass="8534" checksum="D602FCEDB8CA028E" modified="2018-12-05" version="1">MSTLAENHINQNKAWTFSSAGKELNFAGSYWLTVSVLGAKVSAAVGTVSAFVTGLVASAIAFSAGLASGSLITWLGTEERFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX4</accession>
    <name>A0A386PIX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09450</name>
        <name evidence="3" type="ORF">EI377_04190</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679243.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00745"/>
    <dbReference type="EnsemblBacteria" id="AYE34632">
        <property type="protein sequence ID" value="AYE34632"/>
        <property type="gene ID" value="CP523_09450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60031">
        <property type="protein sequence ID" value="QAS60031"/>
        <property type="gene ID" value="EI377_04190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="123" mass="13299" checksum="FD79B612899341A8" modified="2018-12-05" version="1">MRICFPVKSNEGMESVPYGHFGSAPLFVICDLEKDEVSTVDNGDLEHEHGKCQPIKALSGEVVDAVIVGGIGQGAIAKLNSLGIKVYRAVEGTIADNIKAFNDDKLHEFSMNHTCNHHGCSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ39</accession>
    <name>A0A386PJ39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Iron hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09620</name>
        <name evidence="7" type="ORF">EI377_04395</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676696.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02630"/>
    <dbReference type="EnsemblBacteria" id="AYE34662">
        <property type="protein sequence ID" value="AYE34662"/>
        <property type="gene ID" value="CP523_09620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60062">
        <property type="protein sequence ID" value="QAS60062"/>
        <property type="gene ID" value="EI377_04395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027631">
        <property type="entry name" value="FeFe_hydrog_B1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04105">
        <property type="entry name" value="FeFe_hydrog_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="497" mass="54529" checksum="709979120451869C" modified="2018-12-05" version="1">MVQFETQLKKLKHEVLTEIAKLAKDDRVTPEEIEKIPYEVIKGDKALYRCCVYKERAIVLERAKLAAGFLANGDNMVEEFIDIKEDDQIIYVIEAACDRCPINKYSVTDSCRNCLAHKCKEACNFGAISYVAGRAYINQEICKECGMCKKACPYDAIAEVMRPCKKVCPTAAIEISPEDRRAVIKEENCVNCGACMSACPFGAISDKSLIVPVARNLAKGEKIYAIVAPAITGQFGMKITYGQVKNAIKKLGFIDMIEAACGADAVTVHESNEFMTRMDEGDSYMTNSCCPGFLSYIEKKFPSEAGKISGTVSPMIATGRYIKHMDAEATVVFIGPCTAKKSEAVRKLVKDAVDYVLTFEELLALFDAFEIDLEKCDDEVVDDASIYGRGFGAHGGLTASIQNYLRGKGLEVDFKPVKISGGTEIKKTMTMAKIGKLQGNFIEGMICEGGCINGAGTIVTSMKAKAAFNKINSQSTKKAVLDNEKLEEYNNINLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ62</accession>
    <name>A0A386PJ62_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgC</name>
        <name evidence="12" type="ORF">CP523_06875</name>
        <name evidence="13" type="ORF">EI377_01360</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679172.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00040"/>
    <dbReference type="EnsemblBacteria" id="AYE34199">
        <property type="protein sequence ID" value="AYE34199"/>
        <property type="gene ID" value="CP523_06875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59564">
        <property type="protein sequence ID" value="QAS59564"/>
        <property type="gene ID" value="EI377_01360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06875"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="386" mass="43340" checksum="8A57856CADE2DC23" modified="2018-12-05" version="1">MCRKEIVAMILAGGQGSRLGVLTKRLAKPAVPFGGKYRIIDFPLSNCSNSGIYTVGVLTQYKPLDLNEHIGIGAPWDLDRRDGGVNILPPYQHEKGGMWYKGTANAIYQNIEYVDRYDPEYVLILSGDHIYKMNYDKMLEFHKSKEADATIAVIDVPLEEASRFGIMNTRDDLSIYEFEEKPENPKSTNASMGIYIFKWKVLKKFLKEDEKDLESSNDFGKNIIPRMLMKGKRLVAYPFKGYWKDVGTITSLWEANMDLLKRYNDLNLYNNDWKIYSNNPVRPAQYIGKDAAVKNSLIVEGCTVYGTVENSVLFQGVYVGKNTVIRNSVIMPDTKIGNNVTIEKAIIGSNAIIRKECVIGDGNKIAVIAAKEDLSSGTTLEPAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ82</accession>
    <name>A0A386PJ82_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prepilin peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_09645</name>
        <name evidence="11" type="ORF">EI377_04425</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676704.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02635"/>
    <dbReference type="EnsemblBacteria" id="AYE34666">
        <property type="protein sequence ID" value="AYE34666"/>
        <property type="gene ID" value="CP523_09645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60066">
        <property type="protein sequence ID" value="QAS60066"/>
        <property type="gene ID" value="EI377_04425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="9">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="8">
        <location>
            <begin position="101"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="28068" checksum="FE43E7172B7B2F94" modified="2018-12-05" version="1">MDIFFIGLIGLCIGSFLNICIYRIIREESIVFPATHCITCGYEINWYDLIHVFSYAILGGNCRVCSNKISLKYLVIQVLNAILYLIIFFNYGYSLEFLKCCVLASLLIVIGFIDYETKYVYNSTIMFGIAIGIVFLIIQSSLKHGLLWDNINGALIGFSIIYLIVIITKSMGEGDIWIATLCGLFLGVKGVLVTIIISIVIGGITGIFIITFKLKSKKSKIAFGPYLAMGAIVSSIMCNEIINWYIEFLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ89</accession>
    <name>A0A386PJ89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transglutaminase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14405</name>
        <name evidence="4" type="ORF">EI377_09370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676809.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02472"/>
    <dbReference type="EnsemblBacteria" id="AYE35527">
        <property type="protein sequence ID" value="AYE35527"/>
        <property type="gene ID" value="CP523_14405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60913">
        <property type="protein sequence ID" value="QAS60913"/>
        <property type="gene ID" value="EI377_09370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="268"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="356" mass="40430" checksum="28AA382D018E7346" modified="2018-12-05" version="1">MSTYLAYGLCLFIIIWAIKGSTSASLQEKNSKYALDRLIYYFSIFISLIILMLNLDRLIIKILEIQNNYLHIGNINNKLFNIVALAMIFFLIQIIIYQFLKFLSSPLVKGYSKLLSGGLVKVIASSFIFGILKGFVIILILFVAVITFNNTINRGIKLNLFSDISAYCKLEKLISANRPIILNNDIKDYASVNSNFIVYYNGVTLEEGIKSTKEIDNKAIELTSNAKTDREKAKNIYSWIGSNIEYDFYKAEKALNNEKLSKSGAKEAFESRVGICFDYACLYVAMAKKANLGVRLVTGQGFDGKNFGPHAWNEVYLKDEGKWIKVDPTFYKSGDYFDTIDFDKEHIKESIAGEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJF1</accession>
    <name>A0A386PJF1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage V sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14860</name>
        <name evidence="5" type="ORF">EI377_09815</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676094.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01311"/>
    <dbReference type="EnsemblBacteria" id="AYE35607">
        <property type="protein sequence ID" value="AYE35607"/>
        <property type="gene ID" value="CP523_14860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60994">
        <property type="protein sequence ID" value="QAS60994"/>
        <property type="gene ID" value="EI377_09815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011927">
        <property type="entry name" value="SpoVD_pbp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02214">
        <property type="entry name" value="spoVD_pbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="604"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="669"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="731" mass="80472" checksum="969157D4D29415EE" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJM6</accession>
    <name>A0A386PJM6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="4">2.7.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_10845</name>
        <name evidence="11" type="ORF">EI377_05640</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677619.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02503"/>
    <dbReference type="EnsemblBacteria" id="AYE34862">
        <property type="protein sequence ID" value="AYE34862"/>
        <property type="gene ID" value="CP523_10845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60257">
        <property type="protein sequence ID" value="QAS60257"/>
        <property type="gene ID" value="EI377_05640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10845"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="31761" checksum="38317B42AADE5C5B" modified="2018-12-05" version="1">MQINIEALTDILDIQKDSKPLIHCISNLVTINDLVQSILCYSGKPIIAQGIEEVNEIACNSKGLLLNLGTLDSNRVEAMEKSLKAVRKKNIPVLLDIDGIDMSFFRQDTALRFLTRYNINIVKGKLSEFKRLVDSESNINNIDSIDITIKGNCEIRSEIKNVARKFRNIVVVVDKEYYVTDGFSEFFIMNGDVIFEKIYSINTIFSGLIATGMAVTSTKAEMIKAILVAIVTIGVCQELVLQKKKESDGLIILKQHLFDEIFNIKKEDLKKMGNIIYEFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJQ5</accession>
    <name>A0A386PJQ5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbC</name>
        <name evidence="4" type="ORF">CP523_10995</name>
        <name evidence="5" type="ORF">EI377_05790</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677671.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02533"/>
    <dbReference type="EnsemblBacteria" id="AYE34892">
        <property type="protein sequence ID" value="AYE34892"/>
        <property type="gene ID" value="CP523_10995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60287">
        <property type="protein sequence ID" value="QAS60287"/>
        <property type="gene ID" value="EI377_05790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10995"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="187" mass="21642" checksum="18D2CC5DCBE2175E" modified="2018-12-05" version="1">MGKFKFIETKIKDLYIIEPKVFGDNRGYFMETYSKKDFFEAGLTMEFVQDNESKSKKGVLRGMHFQTKHTQGKLVRVTSGEVYDVAVDLRKGSPTYGQWEGVLLTQENKRQFYVPEGFAHGFLVVSDEAVFNYKCTDFYAPEYDSGLLWNDPDVGIEWPLDGIENILLSEKDKVQKTLKELEVPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR6</accession>
    <name>A0A386PJR6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_14275</name>
        <name evidence="10" type="ORF">EI377_09185</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35504">
        <property type="protein sequence ID" value="AYE35504"/>
        <property type="gene ID" value="CP523_14275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60890">
        <property type="protein sequence ID" value="QAS60890"/>
        <property type="gene ID" value="EI377_09185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="451" mass="49008" checksum="E254E364807D1EE7" modified="2018-12-05" version="1">MNRENFSSRLGLLAAAAGSAIGLGNIWKFPYITGQNGGAAFILVYLGCIFLIGIPVMLSEFAIGRKNQVNAVESFKKIAPNTKWHWTGYLATATAFIILSFYAIIAGWVFSYIWRSTSGALRGVAAEGFGDYFSVLTANPVEPMIMTLLVLTITSVIVFFGIKTGIEKFSKIAMPLLLVLIVLLIIRSVTLPGASAGLEFLFKPNFSNLSVHGVLEALGHAFYTLSLGMGIILTFGSYTKKSENLVSLSYQVAIADTIIALMAGMVIFPAVFAYGLEPTAGPGLLFITLPAVFKSMPFGQFFEFMFFVLIAIAAITSTVSLMETAVTFISEQFNLSRKKTILIITSGLFALAIPSVLSFGPLKNLKLLGERSIFDTLDFITGQIFLPIGGILICLFVAWVWGTNNAEKEISSDGKFEFKLKGLYSISVKYIAPLAILIIFLYGLGIFNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS0</accession>
    <name>A0A386PJS0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14110</name>
        <name evidence="7" type="ORF">EI377_09015</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678470.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03098"/>
    <dbReference type="EnsemblBacteria" id="AYE35471">
        <property type="protein sequence ID" value="AYE35471"/>
        <property type="gene ID" value="CP523_14110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60858">
        <property type="protein sequence ID" value="QAS60858"/>
        <property type="gene ID" value="EI377_09015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="203" mass="23400" checksum="A3E04619A1752AE2" modified="2018-12-05" version="1">MILNKEFYKRNALEVAKDLLGKVLVRKIDGIEIRGRIVETEAYIGAIDKASHAYNGRRTERTEPLYEEGGIAYVYFIYGLYHCFNVISGEKDIAEGVLIRAIEPLDNLEYLSNTRFKKDYKSLSRSQKKALTNGPSKLCMALNITKAENYKKLYLDGGLYIENSSYNNFDIVETKRVGIDYAEEAVDFLWRFYIKDNPYVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJV5</accession>
    <name>A0A386PJV5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="8">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">lysS</name>
        <name evidence="12" type="ORF">CP523_08655</name>
        <name evidence="13" type="ORF">EI377_03405</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8 9">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01672"/>
    <dbReference type="EnsemblBacteria" id="AYE34489">
        <property type="protein sequence ID" value="AYE34489"/>
        <property type="gene ID" value="CP523_08655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59891">
        <property type="protein sequence ID" value="QAS59891"/>
        <property type="gene ID" value="EI377_03405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="181"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="503" mass="57838" checksum="D1AEDDD5C55F2E5D" modified="2018-12-05" version="1">MSTEEMNIQELESQFSEQEALRREKLVELQNQDKDPFDVYKVERTHSSEGVKGDFENLEGSIVTVAGRIMSKRGQGKVVFSDIHDRDGRIQLFIKIDEVGEEALKSYKSYDLGDWVAATGEVFKTRTGEVSVKVKEFELICKSLKPLPEKWHGLKDPDLRYRQREVDIITNPEVKDTFIKRAKIIKGIREFLDNKGFIEVETPMLSTIAGGASARPFITHHNTLDIDMYLRIAPELYLKRCIVAGLEKVYDLGRTFRNEGMSVRHNPEFTMIELYQAFADYNDMMEITENMVASVCEKVNGTTKVTYQGTEIDFTPPWRRITMIDAVKEHAGVDFNAIKSNEEAQAIAKEKNLEFKKDLKYVTKGEVLNMLFEEYAEEHMIQPTFICDYPVEISPLTKKKRGNSEFTERFEGFIFGREICNAYSELNDPIVQRDRFNQQEKERELGDDEAYMIDEEFMSALETGMPPTGGLGIGIDRLIMFLTDSASIRDVIMFPTMKPQLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ6</accession>
    <name>A0A386PJZ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ORF">CP523_14605</name>
        <name evidence="20" type="ORF">EI377_09575</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678661.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00191"/>
    <dbReference type="EnsemblBacteria" id="AYE35561">
        <property type="protein sequence ID" value="AYE35561"/>
        <property type="gene ID" value="CP523_14605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60948">
        <property type="protein sequence ID" value="QAS60948"/>
        <property type="gene ID" value="EI377_09575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="404"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="699"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYE35561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QAS60948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="792" mass="88603" checksum="FDA5C8D5074BB4BD" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK10</accession>
    <name>A0A386PK10_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aroA</name>
        <name evidence="9" type="ORF">CP523_11385</name>
        <name evidence="10" type="ORF">EI377_06200</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673265.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02833"/>
    <dbReference type="EnsemblBacteria" id="AYE34966">
        <property type="protein sequence ID" value="AYE34966"/>
        <property type="gene ID" value="CP523_11385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60359">
        <property type="protein sequence ID" value="QAS60359"/>
        <property type="gene ID" value="EI377_06200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11385"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="431" mass="47733" checksum="0B6A775DA6FEFAD3" modified="2018-12-05" version="1">MGNLRIGNSKLKGEVKIPPSKSMAHRAIICASLGSGVSRINNIDYSDDMIATIEGMKVLGAKINKYDDYLEVIGIYSKGSNMNSFRTIDCNESGSTLRFLVPISLLFHGMSKFIGKGNLGKRPLTTYFEIFKEQGIKYFGRDGELDLLIEGKLKPGEFKILGNVSSQFITGLLLTLPLLNGDSKIIITTEMQSKGYVDLTISCMKDFGVEIINKDYKEFIIKGNQNYNSRDYRVEGDYSQAAFYLSANALGSKVLVNDIDLKSLQGDKEIVDILERMGVTFKSENNTLTGIVKDKLKSTIIDGSQCPDIIPILAAVASLSSGTTEIINAERLRIKECDRLKAVTSELSKLGANIKEREDGLIIEGKEELQGGAEVWSFRDHRIAMTLAIAATRCKEAIIIKDFECVAKSYPKFFDDFKMLGGDVHEWNMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK43</accession>
    <name>A0A386PK43_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11540</name>
        <name evidence="5" type="ORF">EI377_06355</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02866"/>
    <dbReference type="EnsemblBacteria" id="AYE34996">
        <property type="protein sequence ID" value="AYE34996"/>
        <property type="gene ID" value="CP523_11540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60389">
        <property type="protein sequence ID" value="QAS60389"/>
        <property type="gene ID" value="EI377_06355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033787997" description="3D domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="3D" evidence="3">
        <location>
            <begin position="330"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="396" mass="43587" checksum="4A9F746C49BDD7D9" modified="2018-12-05" version="1">MIKKTLLSFVVVALCFNISYTAVIKALSPETQAIEESKVKYQQLDESIISLNSDISKLNAEISEINAKLEKNNNETEETEIKIKLINSQIEDAKQDIKSKQIVLDSRLRSMYKSNMSTSILSYLIESKNIFDFFNRMESMGRIISLDKQMVNEIKEKQSFLVKSADELNKKQEELKILKISIEKDLAKVNEKQNSQQEKLSELNSQKDAVAETIEANELKLISHPLSIVNSDNSSVQDISDAISTLKALIPQLNTESVIDIANDGISTGNAKIEEINSANNSNANTNNNNSQNNNNLASKGTFTMEATAYSGGTVTAMGFKPVRDPNGISTVAVDPSVIPLGSKVFVSGYGYAIASDTGGAIKGNIIDLYFNSHEECMAFGRQNVTVSLIAYPGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKA1</accession>
    <name>A0A386PKA1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alkylphosphonate utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12280</name>
        <name evidence="5" type="ORF">EI377_07105</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673603.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03012"/>
    <dbReference type="EnsemblBacteria" id="AYE35132">
        <property type="protein sequence ID" value="AYE35132"/>
        <property type="gene ID" value="CP523_12280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60524">
        <property type="protein sequence ID" value="QAS60524"/>
        <property type="gene ID" value="EI377_07105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="113" mass="12613" checksum="F315590969FFF220" modified="2018-12-05" version="1">MSNLPNCPKCNSEYTYEDGNLFICPECAYEWTLESEKESNEDIQIVKDANGNILNDGDSVTIIKDLKVKGSPSPLKKGTKVKNIRLVEGDHNIDCKIDGFGAMQLKSEFVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKA7</accession>
    <name>A0A386PKA7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S74 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03071"/>
    <dbReference type="EnsemblBacteria" id="AYE35701">
        <property type="protein sequence ID" value="AYE35701"/>
        <property type="gene ID" value="CP523_15375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S74" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122616" checksum="016C0F17EF2557BA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKB6</accession>
    <name>A0A386PKB6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15545</name>
        <name evidence="3" type="ORF">EI377_10255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35734">
        <property type="protein sequence ID" value="AYE35734"/>
        <property type="gene ID" value="CP523_15545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61073">
        <property type="protein sequence ID" value="QAS61073"/>
        <property type="gene ID" value="EI377_10255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="129" mass="15189" checksum="2B93D64AE5CD0940" modified="2018-12-05" version="1">MDKRNRLVAPRNVVNTKMLYSFYILKELAKGETIFGNKVLEAFKNRFEYSELPFPVSSSTIYETLYDLETKGYVKSHWSGDEFLNKRSKKIYSITDEGVYFYKNHISDYVNNLNKTKSTLDVMIEMLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKC5</accession>
    <name>A0A386PKC5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="4 7">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pduL</name>
        <name evidence="8" type="ORF">CP523_12485</name>
        <name evidence="9" type="ORF">EI377_07370</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PduL family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675315.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02016"/>
    <dbReference type="EnsemblBacteria" id="AYE35172">
        <property type="protein sequence ID" value="AYE35172"/>
        <property type="gene ID" value="CP523_12485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60575">
        <property type="protein sequence ID" value="QAS60575"/>
        <property type="gene ID" value="EI377_07370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12485"/>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="23405" checksum="797FFDAAA1F89128" modified="2018-12-05" version="1">MDNCEALLKLLLEAVKDKGINTEVIENSNEIPVGISNRHVHLSQRDLDKLFGEGYKLTKIKELSQPGQYACKETVTICGPKGAIEKVRILGPVRSKSQIEVLMGDCIKLGAAPHVRLSGELNKTSGITVIGPNGSVQLEEGLIVAQRHIHMTPEDAKKLGVCDGEIVSIKFDNLRGGTYSNVAIRANDTSKLECHLDIEEANAVGINSKSKITIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKC6</accession>
    <name>A0A386PKC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35721">
        <property type="protein sequence ID" value="AYE35721"/>
        <property type="gene ID" value="CP523_15480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="63" mass="7238" checksum="FC42B46F6AF30346" modified="2018-12-05" version="1">MYKLYNNISVGLCSSLLFYILTYISNEIARLLIQNSGLLVILIMFILVLISLHIINIIVKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKH3</accession>
    <name>A0A386PKH3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="4">2.7.1.49</ecNumber>
            <ecNumber evidence="4">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiD</name>
        <name evidence="3" type="ORF">CP523_12865</name>
        <name evidence="4" type="ORF">EI377_07745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="4"/>
    <dbReference type="EC" id="2.7.4.7" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678240.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03038"/>
    <dbReference type="EnsemblBacteria" id="AYE35242">
        <property type="protein sequence ID" value="AYE35242"/>
        <property type="gene ID" value="CP523_12865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60637">
        <property type="protein sequence ID" value="QAS60637"/>
        <property type="gene ID" value="EI377_07745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="29301" checksum="F032BD4EB007C32A" modified="2018-12-05" version="1">MRDYRISTLTIAGSDSSGGAGVQADLKTFSAIGTYGMSVITAITAQNTQGVFLVEDLSNEIIKKQIEVVFEDIEPKAVKIGMVSSPEIILGIVEMLKKYNPKYLVVDPVMISKSGYSLLKPEAKKNLIEYLLPMAYVLTPNIMEAEEISGVKINNLEDMKEAGKKILEIGSKYVLMKGGHLDGDAVDVLIGENTFEIYKKERLNRKNTHGTGCTLSSAITSYLALGYSIEKAVELSKLYITEAIRYSFDIGNGVGPVNHFYKFQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI8</accession>
    <name>A0A386PKI8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">CP523_14095</name>
        <name evidence="9" type="ORF">EI377_09000</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678464.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03095"/>
    <dbReference type="EnsemblBacteria" id="AYE35468">
        <property type="protein sequence ID" value="AYE35468"/>
        <property type="gene ID" value="CP523_14095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60855">
        <property type="protein sequence ID" value="QAS60855"/>
        <property type="gene ID" value="EI377_09000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14095"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="154" mass="16538" checksum="00DEE75901C7BBF5" modified="2018-12-05" version="1">MRIIEGDLIGKGKRYAIVAARFNEFIVSKLVSGAIDAFKRHGVDEDSITVTWVPGAFEIPLVAKKLAQSKNYDAVVCLGAVIRGTTSHYDYVCSEVSKGVANIGLETEIPVIFGVITTENIEQAIERAGTKSGNKGFDAAVSAIEMSNLLGKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKT7</accession>
    <name>A0A386PKT7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="5" type="ORF">CP523_13105</name>
        <name evidence="6" type="ORF">EI377_07975</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02562"/>
    <dbReference type="EnsemblBacteria" id="AYE35286">
        <property type="protein sequence ID" value="AYE35286"/>
        <property type="gene ID" value="CP523_13105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60680">
        <property type="protein sequence ID" value="QAS60680"/>
        <property type="gene ID" value="EI377_07975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="134" mass="14732" checksum="C79D6E3816949B3F" modified="2018-12-05" version="1">MNKAILIGRLTKDPELNYAASSGTAVTRFTLAVNRQFKKDEADFINCIAFGKTGEVIAQYLTKGRQLAITGNIRTGSYDAKDGTKRYTTDVIVESCEFIGNGQGNDASNKINNTFDNKNFDEDMTPVDDGDMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL18</accession>
    <name>A0A386PL18_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatD</name>
        <name evidence="3" type="ORF">CP523_13740</name>
        <name evidence="4" type="ORF">EI377_08630</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with MurT.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobB/CobQ family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677157.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02074"/>
    <dbReference type="EnsemblBacteria" id="AYE35406">
        <property type="protein sequence ID" value="AYE35406"/>
        <property type="gene ID" value="CP523_13740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60794">
        <property type="protein sequence ID" value="QAS60794"/>
        <property type="gene ID" value="EI377_08630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13740"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02213">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043702">
        <property type="entry name" value="Lipid_II_synth_GatD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="241" mass="27102" checksum="5F3283F8B0FC3B0C" modified="2018-12-05" version="1">MELNICHLYPDLLNVYGDVGNILILKHRAEARGIKVNIINTSLNDDFDHENIDFLFFGGGQDYEQSIVSEDLNTNKKDSIKKFVESGKVTLAICGGYQLLGNYYRAPNGEKINGLGILDIYTESGDTRFIGNTVIYNEDFNETYVGFENHSGKTYINNLKPLGKCKHGYGNNGEDGLEGCIYKNTFCTYFHGSLLSKNPELADKFLKLALENKYGEINLEPLDDSLELKAKEVMINRLDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL52</accession>
    <name>A0A386PL52_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phospho-sugar mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_14665</name>
        <name evidence="12" type="ORF">EI377_09630</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678857.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00141"/>
    <dbReference type="EnsemblBacteria" id="AYE35572">
        <property type="protein sequence ID" value="AYE35572"/>
        <property type="gene ID" value="CP523_14665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60958">
        <property type="protein sequence ID" value="QAS60958"/>
        <property type="gene ID" value="EI377_09630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="42"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="206"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="322"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="484"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="575" mass="64689" checksum="E37B721E4560AF4D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLA9</accession>
    <name>A0A386PLA9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF861 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12470</name>
        <name evidence="2" type="ORF">EI377_07355</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675321.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02019"/>
    <dbReference type="EnsemblBacteria" id="AYE35169">
        <property type="protein sequence ID" value="AYE35169"/>
        <property type="gene ID" value="CP523_12470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60572">
        <property type="protein sequence ID" value="QAS60572"/>
        <property type="gene ID" value="EI377_07355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010424">
        <property type="entry name" value="EutQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36169">
        <property type="entry name" value="PTHR36169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06249">
        <property type="entry name" value="EutQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="223" mass="24922" checksum="8776920BB64D40E9" modified="2018-12-05" version="1">MKKLICAKDIEELIVNGKKTFYIDGSEIITPAAQDLAINNQIKFTNESPKVEASTTQKLDPIKCPNIEGLDSDTLVKFFKVLMEKGLLQDLLECLKPKNTLFDAECDPSGLKVVRGNTVKMDVFDTGDPNVRAYFQELVSKEESKMSAGFLVIENSKFEWELTYEEIDYVIEGTLTVEINGKTYTAHAGDVLFVPSGSKVVWGSPDKARVFYSTYPANWADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLC0</accession>
    <name>A0A386PLC0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_12575</name>
        <name evidence="8" type="ORF">EI377_07475</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35189">
        <property type="protein sequence ID" value="AYE35189"/>
        <property type="gene ID" value="CP523_12575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60593">
        <property type="protein sequence ID" value="QAS60593"/>
        <property type="gene ID" value="EI377_07475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363136" description="GRAM_POS_ANCHORING domain-containing protein" evidence="5">
        <location>
            <begin position="31"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="6">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="377" mass="43289" checksum="AED067676F055776" modified="2018-12-05" version="1">MIKKKIQKIICTAIATGMVIGVTPICIAEAATNEVINSSKENLEISENDLPELTYAVEEMREAITLVDNANFTEKENYDRLVVFSKSSLDRLRSLGVKNKYAEWIEESGNEVRALTYRIDRVLHAIDNVKVVFSEERKDTLENKENVINTLNLVIYQESESRVLNKITLDKAKEIYNNYYKEFIEESKPKEVVNGAIPKEDENKDNKKEEQPNNEENRQNNADVDNKQDVKNEYDKQDNKDEENKQNVENEDIKKVESKKTNTEKEDSKNENLENKDDKNVKDTESKKTLLEKDNKSNIVDMSVDEKNHPEDTKVNSKKPEIKKPEIKKQKIKYNSAKVNKNNKAKQNKLPNTGKTPVTLISGILALLAGVLTIKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLC5</accession>
    <name>A0A386PLC5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10550</name>
        <name evidence="5" type="ORF">EI377_05330</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35858">
        <property type="protein sequence ID" value="AYE35858"/>
        <property type="gene ID" value="CP523_10550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62165">
        <property type="protein sequence ID" value="QAS62165"/>
        <property type="gene ID" value="EI377_05330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362795" evidence="3">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="192" mass="21058" checksum="B18F20BA73B3C974" modified="2018-12-05" version="1">MTFAKSSSSKSSSSSSKHSSSSSKSKSSSSFKSGSFKSNNSTKKSTINKDSNTNKNSSGFKSGSFKSSDSTNNKDSSTNNKDSSSNKKSSNEFKSGNFSESKNNGNSSSKGFSSGSFSTTDKENNNKDTQDKDYENNTKPKEKFGIPFGFPTRRYSNYRYGSGFSLSTFFTISIIFILIVVLIKIYLKKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLE0</accession>
    <name>A0A386PLE0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YibE/F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14045</name>
        <name evidence="3" type="ORF">EI377_08950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35878">
        <property type="protein sequence ID" value="AYE35878"/>
        <property type="gene ID" value="CP523_14045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62189">
        <property type="protein sequence ID" value="QAS62189"/>
        <property type="gene ID" value="EI377_08950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="385" mass="42063" checksum="316E3F82306D2BD0" modified="2018-12-05" version="1">MNIKDYRQDIISILITVILSVVIIFASSSIFNNGFLNDKLNKGVEYYKAEVKEVLEEKLQVDKYIEDIELGYQNVTLKILDGPYKGNEYNITNNVSRLYNFKVEEGSKIIAGMYFMDGSLKDVTIIGYKRSNTLGILVLLFFIIILLVGGFKGLKSIISLLFTMICVVFLMLPLMLRGINPIISAIVIAIISITVTLLLVSGINKKSFSAILGTLFGVLIAGILAYVFGYMSYLSGINMEEAESIMYIAETTGLKINGIMFAGILVASLGAVMDVAMSISSSVFEINSINKEINIKGLFKSGMNIGRDIIGTMSNTLILAFAGGSLNTLILIYSSNMTANRLLNLDVLGTEIIQGLAGSIGIILTVPITAIISSYLSKKEKMNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLR0</accession>
    <name>A0A386PLR0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_13890</name>
        <name evidence="6" type="ORF">EI377_08785</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679305.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000078.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00003"/>
    <dbReference type="EnsemblBacteria" id="AYE35429">
        <property type="protein sequence ID" value="AYE35429"/>
        <property type="gene ID" value="CP523_13890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60817">
        <property type="protein sequence ID" value="QAS60817"/>
        <property type="gene ID" value="EI377_08785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="255" mass="29210" checksum="7F50864D31E6B8E5" modified="2018-12-05" version="1">MDLIKVSNIKLTYQSLKGETEAIKGVDFSVPKGEFVSIIGPSGCGKSTLLNIISGLLKPSGGEVIYNDKDVKNRLDKMGYMFQKDYLFEWLTVWDNVLLGLKIKKILTKESIDRVDKLLENYDLTKFKNHKPNELSGGMRQRVALIRTLALSPEVLLLDEPFSALDYQTRLKVCDEVTDIIKREEKTAIMVTHDLGEAIATSDRIIMLTKRPSKVKIDVKIEFANKEATPFQRRKEPEFNEYFNLLWKGLDKYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLV2</accession>
    <name>A0A386PLV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="12">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_14300</name>
        <name evidence="12" type="ORF">EI377_09210</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02449"/>
    <dbReference type="EnsemblBacteria" id="AYE35509">
        <property type="protein sequence ID" value="AYE35509"/>
        <property type="gene ID" value="CP523_14300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60894">
        <property type="protein sequence ID" value="QAS60894"/>
        <property type="gene ID" value="EI377_09210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="485" mass="55466" checksum="987450E7747DB95D" modified="2018-12-05" version="1">MSRRNEVRDQYLTTNQGAPITNDKNSLTVGDNGPVLLKDTNLIEKLAHFDRERIPDRVAHAKGSSAHGYFKLYNSMKEYTKAKVFTDTKNITPVIVRFSTVVGSKGSAETARDPRGFAVKFYTEEGNYDLVGNDIPVFFIRDAIKFPDMFHAFRPSPVTDLMDKNRFWDFIVNSPESTHMITWVFSDKGTRKSFIHMPGFGVNTFVWVNDKGKRMYVKYHWIPMAGDETIDRKEAEKLAGSDPDIATRELYDVLNNGEEVEYELAVQLMDPILEDSLSFNPIDATKVWPEDKFPLMKVGKLVLTHPPTNFFEESEQVAFAPGNFVPGIEASNCKLLQGRLFSYPDSQRYRLGTNFTQLPINKPKVPVVNNQRAGNMQYDKHSGIVDYNPNLLNDGNPEPTKEKGKVCLEYVEGYIEQKPIEKENDFQQAGGQYRSYNKIEREHLIDNIVNDLKEVDKRIQLKAIENFMKADKEFGTRVKLGLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM52</accession>
    <name>A0A386PM52_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678762.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35699">
        <property type="protein sequence ID" value="AYE35699"/>
        <property type="gene ID" value="CP523_15365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="82" mass="9415" checksum="830C71C2D5036CF8" modified="2018-12-05" version="1">MLDINENINLNGNVNIENQQVVNMTASIYTEGNNYPNINITVVDKKIYKKKFDVCKQGINEFIDKALKKQYEMLGDVTSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMC6</accession>
    <name>A0A386PMC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07130</name>
        <name evidence="3" type="ORF">EI377_01875</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673879.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35839">
        <property type="protein sequence ID" value="AYE35839"/>
        <property type="gene ID" value="CP523_07130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62149">
        <property type="protein sequence ID" value="QAS62149"/>
        <property type="gene ID" value="EI377_01875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="447" mass="49046" checksum="CAA9B47A10474076" modified="2018-12-05" version="1">MKTMLSLALPITFQNFITSSLNLVDNLMIGKLGEEAIASVGLANQYFFIFMLCLSGINAGASVFMAQYWGRKDTSNIKKILGIDISVGFIASIIFGGIALIFPEIIMRILSKDPRVVELGSSYLRIVSISYLFTNVTQGFSAALRSTEQPKAPMYASLLGVLCNAFLNWIFIFGNLGAKEMGVAGAALATTIARLIEMIYIVFMVYFKKNIVSANIKELFGFNVDYIRMYFKTSTAVILNELLWSLGMTAYSIAYAQIGTSAVATMQISTTLNNMFMVLSIGLASAAAIMVGNKIGAKQEKVAIDYSIKLEVVAPILGLLVGVLLWITTPLIVKPFSVTPETTKNTITVLRIMAIFCPLRFYNVLMIVGIFRGGGDTLYSTLVQLGTIWCFAVPLSFLGATLLKFPITAVYFLVCCEELVKFFFERARLKSGKWLRDVIGETQGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAR3</accession>
    <name>A0A386PAR3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LTA synthase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_00440</name>
        <name evidence="10" type="ORF">EI377_10930</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LTA synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676289.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00616"/>
    <dbReference type="EnsemblBacteria" id="AYE33023">
        <property type="protein sequence ID" value="AYE33023"/>
        <property type="gene ID" value="CP523_00440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61192">
        <property type="protein sequence ID" value="QAS61192"/>
        <property type="gene ID" value="EI377_10930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="8">
        <location>
            <begin position="249"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="594" mass="68772" checksum="CB11ECDF65EB0DE9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAT9</accession>
    <name>A0A386PAT9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_00505</name>
        <name evidence="7" type="ORF">EI377_10995</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00630"/>
    <dbReference type="EnsemblBacteria" id="AYE33035">
        <property type="protein sequence ID" value="AYE33035"/>
        <property type="gene ID" value="CP523_00505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61204">
        <property type="protein sequence ID" value="QAS61204"/>
        <property type="gene ID" value="EI377_10995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="99"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="438"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="574" mass="63608" checksum="78C073577552EF7E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBL8</accession>
    <name>A0A386PBL8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">CP523_01045</name>
        <name evidence="12" type="ORF">EI377_11540</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674488.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02310"/>
    <dbReference type="EnsemblBacteria" id="AYE33140">
        <property type="protein sequence ID" value="AYE33140"/>
        <property type="gene ID" value="CP523_01045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61310">
        <property type="protein sequence ID" value="QAS61310"/>
        <property type="gene ID" value="EI377_11540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="78"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="296" mass="31419" checksum="AE06AF05CB87DF8A" modified="2018-12-05" version="1">MESAKEKNNKTKYIIEKISRFIFLGSALIAVISLLLIIGFVFYKGLTPFISKGYSIGGFIFGTEWVPSSDKFGILPMILASILGTLGSLVIGVPVGILTAVFIAEIAPKKFGKIISSAVELLAGIPSVLYGVFGLAIIVPWIKETFNLPKGQSLLAVILVLSIMMLPTIITVAETAIRAVPKTYKEGSLALGASHIETIFKVVLPAAKSGILAAIVLGVGRAIGETMAIILVAGNSPIIPKGVMEGVRPLTTNIALEMGYAFGTHQEMLFATGVILFIFILILNLVLSKLSNKEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBQ6</accession>
    <name>A0A386PBQ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">acpP</name>
        <name evidence="5" type="ORF">CP523_01260</name>
        <name evidence="6" type="ORF">EI377_11760</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674351.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02266"/>
    <dbReference type="EnsemblBacteria" id="AYE33180">
        <property type="protein sequence ID" value="AYE33180"/>
        <property type="gene ID" value="CP523_01260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61350">
        <property type="protein sequence ID" value="QAS61350"/>
        <property type="gene ID" value="EI377_11760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01260"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="73" mass="8262" checksum="F867A792156355EF" modified="2018-12-05" version="1">MLFEKIQKVIVDQLGVDESEVKLETSFEELGADSLDLFQVVIELEEEFGIQLEEAEGLKTVKDAVDYVQSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBU0</accession>
    <name>A0A386PBU0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cobalt-precorrin-2 C(20)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.151</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_01465</name>
        <name evidence="10" type="ORF">EI377_11985</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60053"/>
            <dbReference type="ChEBI" id="CHEBI:60060"/>
            <dbReference type="EC" id="2.1.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.151" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675621.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00845"/>
    <dbReference type="EnsemblBacteria" id="AYE33220">
        <property type="protein sequence ID" value="AYE33220"/>
        <property type="gene ID" value="CP523_01465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61392">
        <property type="protein sequence ID" value="QAS61392"/>
        <property type="gene ID" value="EI377_11985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01465"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043781">
        <property type="term" value="F:cobalt-factor II C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="24640" checksum="290D313661251091" modified="2018-12-05" version="1">MAVLYGIGVGPGDKELITIKGVRAIENSEVIVAPSAIDDGESIALETVKDYIKEGSEVIVKHFPMGTKDRVSKAKEAYDLIEGKLKEGKNVSFLTIGDPYVYSTYIHLLKHIEERGFEVKTIPGVTSFCAAASIVDRTLVVGNNPLMILPATRVKDIKDEKYVVIMKVYKHEEEVLNVLEEKGFNYVYVSKAGREGQRILENKEEIINSREYMSLILASKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC56</accession>
    <name>A0A386PC56_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_02170</name>
        <name evidence="15" type="ORF">EI377_12690</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674053.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00533"/>
    <dbReference type="EnsemblBacteria" id="AYE33350">
        <property type="protein sequence ID" value="AYE33350"/>
        <property type="gene ID" value="CP523_02170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61520">
        <property type="protein sequence ID" value="QAS61520"/>
        <property type="gene ID" value="EI377_12690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="423"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="519"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="832"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="768"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="769"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="876" mass="97435" checksum="82FAEF3C61D0BC18" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC90</accession>
    <name>A0A386PC90_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">MgtC/SapB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03315</name>
        <name evidence="9" type="ORF">EI377_13830</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677219.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02121"/>
    <dbReference type="EnsemblBacteria" id="AYE33565">
        <property type="protein sequence ID" value="AYE33565"/>
        <property type="gene ID" value="CP523_03315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61728">
        <property type="protein sequence ID" value="QAS61728"/>
        <property type="gene ID" value="EI377_13830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="235" mass="25581" checksum="795809FAE7633E71" modified="2018-12-05" version="1">MPLQEIGLRLLLSIIIGGVIGYERESTNSPAGFRTHILVALGATVISLIQVEMVNKSMVLIAADPTLANSIKIDMGRLGAQVVSGIGFLGAGTIIHTKGSIKGLTTAASLWVVACVGLATGFGYYSISILAGIAIVLVLVTLKRFENRFINNRGICKVYIEYIDKQEAMSCIEGYMLKKGIKIANIEFYVNDIDETNEIKSCLITVELPKTMEINELLVQCGTNEYITQIYELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCJ9</accession>
    <name>A0A386PCJ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_01400</name>
        <name evidence="10" type="ORF">EI377_11915</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00831"/>
    <dbReference type="EnsemblBacteria" id="AYE33207">
        <property type="protein sequence ID" value="AYE33207"/>
        <property type="gene ID" value="CP523_01400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61379">
        <property type="protein sequence ID" value="QAS61379"/>
        <property type="gene ID" value="EI377_11915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="8">
        <location>
            <begin position="389"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="676" mass="74226" checksum="D26BE6B86379363F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCN5</accession>
    <name>A0A386PCN5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">topA</name>
        <name evidence="12" type="ORF">CP523_00755</name>
        <name evidence="13" type="ORF">EI377_11250</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674635.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02369"/>
    <dbReference type="EnsemblBacteria" id="AYE33084">
        <property type="protein sequence ID" value="AYE33084"/>
        <property type="gene ID" value="CP523_00755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61253">
        <property type="protein sequence ID" value="QAS61253"/>
        <property type="gene ID" value="EI377_11250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="699" mass="79073" checksum="1C57AF5A046AE0AE" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCV2</accession>
    <name>A0A386PCV2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">mltG</name>
        <name evidence="8" type="ORF">CP523_01125</name>
        <name evidence="9" type="ORF">EI377_11625</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674433.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02293"/>
    <dbReference type="EnsemblBacteria" id="AYE33154">
        <property type="protein sequence ID" value="AYE33154"/>
        <property type="gene ID" value="CP523_01125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61324">
        <property type="protein sequence ID" value="QAS61324"/>
        <property type="gene ID" value="EI377_11625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="38698" checksum="15F6B69130478203" modified="2018-12-05" version="1">MKNSNIKKVILIIIILTIIIVPFVIVGRTIKNPVKVDGNVIINVEEGDSFYGVLNKLSKREEIRGLPIIKLYLKITNKNLEVKPGTYEIHNKMTVNDIVETLTSESTKNLIKFTVPEGYTVDDIASKLEKEKICTKGDFIKAVKQYNLPPFIKNNDNKKYNLEGYLFPDTYIIKKDEKPGEIVQVMVSRFEEAFEEALKETNIKTSDEDVETVITIASMIEKEARVDKERPIIASVIANRVSEGMNLQIDATVIYALGEHVEKVLYSHLETESPYNTYKINGLPIGPISNPGMPSILAALKPATTDYLFYVLEKDMKHHFFTRDENEFMSKLKELGYLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD36</accession>
    <name>A0A386PD36_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_05135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01817"/>
    <dbReference type="EnsemblBacteria" id="AYE33903">
        <property type="protein sequence ID" value="AYE33903"/>
        <property type="gene ID" value="CP523_05135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="7"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="393" mass="42459" checksum="731C6E7E0CA24DBA" modified="2018-12-05" version="1">MFMKNKNGLIVLIASLAIQLVMGTIFMWSLFNIPFVEKFGWEKGAVVFTFSIMIFFFTFSAIFGGRLQDKYGPRKIATLGSILFGAGVILSSTATTVWQLYIYYGVVAGIGAGFVYVCPVATCVKWFPNKRGLVTGLAVSAFGVSALVFKPIAIHFINVASVPGAFLYLGAIYTLLSVVSAQFLFLPEKNNSSSEKKNNIQEDSNNVELKDMLKEVKFYVLAMMYLFGGTACLTVIGLARDIGVDLANITPEAATNAVAVISLFNAGGRLLWGAVSDKLGIEKSVGVIYLIMTLSMAYTAFGDLQGNKYFIVLAFMAISYGGMLTIFPTIIADYYGTKNFGVNYGIIFAVYGLGAVIGPMTATAIGLNLTFVISTILCFIAVIGATYIFMKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD49</accession>
    <name>A0A386PD49_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04145</name>
        <name evidence="5" type="ORF">EI377_14665</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02755"/>
    <dbReference type="EnsemblBacteria" id="AYE33720">
        <property type="protein sequence ID" value="AYE33720"/>
        <property type="gene ID" value="CP523_04145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61875">
        <property type="protein sequence ID" value="QAS61875"/>
        <property type="gene ID" value="EI377_14665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="536"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="667" mass="76900" checksum="2641DC09CAC6BB31" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDC8</accession>
    <name>A0A386PDC8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02905</name>
        <name evidence="6" type="ORF">EI377_13430</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677015.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00987"/>
    <dbReference type="EnsemblBacteria" id="AYE33487">
        <property type="protein sequence ID" value="AYE33487"/>
        <property type="gene ID" value="CP523_02905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61658">
        <property type="protein sequence ID" value="QAS61658"/>
        <property type="gene ID" value="EI377_13430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="430" mass="48416" checksum="CF43B1B05A4C1ECB" modified="2018-12-05" version="1">MNGIRNDYLRNLLIGLDRKVPILGGHEIIPINFDNAATTPVFKRVMSRMLEISEYYGSIGRGMGQKSEYSTKVYNECREYILKFFNAPNDRYTAIFVNNTTEGINRLSNMLICNKNDIVITTRMEHHSNDLPWRGKCNLDYIEVDDLGRLMINELEDKLESHNGNVKYVSVTAASNVTGYVNDIYKIARIVHKYGAKLIVDGAQIVAHKKVKMVDGDLNESIDFLVFSAHKMYAPFGSGAIVGLKDTFEEVESDFKGGGTVNTVLDYEEVYLDPPDKQEAGSPNFFGAVALVESMKQLREIGYDEIDSNEHALLKRAIDGMKSIPKVREYGDLVNIEDRLGIVVFNVEGVYHAEVARALAKLRGIAVRQGAFCAHPYVKRLLKLTNEEAAKHLTDPMYKMPGMIRASFGIYNSVDEVDIFLNTLELISRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDF9</accession>
    <name>A0A386PDF9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05900</name>
        <name evidence="9" type="ORF">EI377_00390</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675027.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01883"/>
    <dbReference type="EnsemblBacteria" id="AYE34033">
        <property type="protein sequence ID" value="AYE34033"/>
        <property type="gene ID" value="CP523_05900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59406">
        <property type="protein sequence ID" value="QAS59406"/>
        <property type="gene ID" value="EI377_00390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="310"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="410" mass="47478" checksum="938EA4B7C70077C9" modified="2018-12-05" version="1">MYLGYIKSSIRNKKLFTLLSIVQITITMVLVIDVLINLSTINYKEREFKNNLNVDLNNTYEFIIYGNDAGSSDLKKKLSSYFDIGSYEYYHSNIEEFKNNEKFIEKFKLDKESNNNEVQILKIDKNLFNILDINIIDGRSLNEEDFNLDNDNIPIIFSEEYKDIVNIGDVVTYEGILTQRYKVVGFYNKNIKWFPSNDIQFFALEDLGKMGITIPSKKEKEVNFYGLAINNSTYITSDKLNKSEIQNIVDDVNKDYGLNIEILSIKDILNRFKQGIYPFILQKVFFSIFMLVSSCLGLASNMSFTIINRKKEFGIRLANGFRKKDIKLLVISEMLLLSLISTIIAMIFKFTEFYKNRQFSIAEKIIVPQFSIIDFVVAIVLVVIIIVISSIIPLRNIDKLQPKEMIGTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDM3</accession>
    <name>A0A386PDM3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MBOAT family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Membrane-bound O-acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_06265</name>
        <name evidence="12" type="ORF">EI377_00740</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34103">
        <property type="protein sequence ID" value="AYE34103"/>
        <property type="gene ID" value="CP523_06265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59470">
        <property type="protein sequence ID" value="QAS59470"/>
        <property type="gene ID" value="EI377_00740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="527" mass="60948" checksum="4981754350E3B0E8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDT3</accession>
    <name>A0A386PDT3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-amylase</fullName>
            <ecNumber evidence="3">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03665</name>
        <name evidence="6" type="ORF">EI377_14195</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677707.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02212"/>
    <dbReference type="EnsemblBacteria" id="AYE33627">
        <property type="protein sequence ID" value="AYE33627"/>
        <property type="gene ID" value="CP523_03665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61791">
        <property type="protein sequence ID" value="QAS61791"/>
        <property type="gene ID" value="EI377_14195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="13"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="554" mass="65424" checksum="105C087FB71A5187" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDW2</accession>
    <name>A0A386PDW2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06815</name>
        <name evidence="5" type="ORF">EI377_01290</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679265.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000075.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00005"/>
    <dbReference type="EnsemblBacteria" id="AYE34193">
        <property type="protein sequence ID" value="AYE34193"/>
        <property type="gene ID" value="CP523_06815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59557">
        <property type="protein sequence ID" value="QAS59557"/>
        <property type="gene ID" value="EI377_01290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="295" mass="33381" checksum="25D5AA6B718DA28D" modified="2018-12-05" version="1">MKIGLVLAGGGARGAYQIGVWRALRELNIEKYVKVISGTSIGALNAVLFMKGDLSLAEEIWKNIKPNEILPINQADLKIRKTLLDVGIKNIHFIKKYIPKMILGGNISRGGLEKIIDNLELNFITDSDIRCYVTCTDIDKLEAKHFLINKYSCDEIKKILLASSAIPMIYEKQKVEGEEYLDGGIVDNVPIESIYDEVCDLLIIVHLSKESKIDKRKFNNLDIIEIVPSVVEDGALDGVLEFDSKISKERMIVGYDDTINTITPIIKLVRFLDKEENKMTKERNNIIKRIKNIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE20</accession>
    <name>A0A386PE20_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00880</name>
        <name evidence="3" type="ORF">EI377_11375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674562.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02343"/>
    <dbReference type="EnsemblBacteria" id="AYE33108">
        <property type="protein sequence ID" value="AYE33108"/>
        <property type="gene ID" value="CP523_00880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61278">
        <property type="protein sequence ID" value="QAS61278"/>
        <property type="gene ID" value="EI377_11375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="178" mass="20678" checksum="DD1E05B6CF189800" modified="2018-12-05" version="1">MDKQESNILELLEYLQEIIDNAPKVPITGKTMIDKREVDEIIDQIINYMPDQLKKAKWVVSEKDRILQDAQKEYENLKKDTFELMKKNVENHDIVKEAKIRANEIIALAQRDAKAIRLGSREYSNEILTQLDREIESKKIALIQTMQTSFEQVAKEIDESMSQAAVVIKENIAELRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE22</accession>
    <name>A0A386PE22_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_049178069.1">
        <property type="nucleotide sequence ID" value="NZ_CP023671.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34275">
        <property type="protein sequence ID" value="AYE34275"/>
        <property type="gene ID" value="CP523_07330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025912">
        <property type="entry name" value="YrvL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14184">
        <property type="entry name" value="YrvL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="142" mass="15852" checksum="D8C98290A92F07E5" modified="2018-12-05" version="1">MKEIWNRHKEKLITFLLCGLLFVGVLSIIALLGGAIMKIFGFEYESIGSIILFFVIATIISYPFSLIAEVLPKVVLSFGKLPKQMAILFYIILDTFATFYGLRVVDYFMQSVSATDISIIIVSLILALFGINDVDKKTKGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB4</accession>
    <name>A0A386PEB4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03490</name>
        <name evidence="2" type="ORF">EI377_14015</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677910.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33594">
        <property type="protein sequence ID" value="AYE33594"/>
        <property type="gene ID" value="CP523_03490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61758">
        <property type="protein sequence ID" value="QAS61758"/>
        <property type="gene ID" value="EI377_14015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="9233" checksum="A72DDEFA078D2224" modified="2018-12-05" version="1">MYNNAYNQSKILYREVKSYEEAYRYNSEYQELKPRTIKVESRFLKEDNKNEKKFSIMPIIFESIEALIEIIIDIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC4</accession>
    <name>A0A386PEC4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03540</name>
        <name evidence="7" type="ORF">EI377_14065</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677931.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02259"/>
    <dbReference type="EnsemblBacteria" id="AYE33604">
        <property type="protein sequence ID" value="AYE33604"/>
        <property type="gene ID" value="CP523_03540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61768">
        <property type="protein sequence ID" value="QAS61768"/>
        <property type="gene ID" value="EI377_14065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="256"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="359" mass="42441" checksum="80D856CD60C3ECAC" modified="2018-12-05" version="1">MFNVMIVDDLQIMRKDIIRKKVWGEKTGFLVKAEASNGEEALEKIKENNIDLIITDIKMPKVDGLELLKKIKDKNSSVCVILLSEYSEFKYAREGIIFGAFDYLTKPINEKQLEEALLRAKKFLVNQRKKEEKINKLDKLVKEDDIIELIEYIKTNNELALNKVEDIINSAVEKNFENLQSDKYIVKKVADEIIYKILLEYKWYNKFVNISNWKKSSNFRCDDISLIKKHIKEIIKKLMDDIAIFKFTNLKNRRVEEICNIIIENIENNISLELICKNMNMNKSYISHFFRKATGKTIVEHMTFIKMERAKNLLLNEDIKVYEVSYKLSYNDVEYFSRTFKKYVGISPKEFKNLQKMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEL5</accession>
    <name>A0A386PEL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic sulfite reductase subunit AsrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">asrB</name>
        <name evidence="3" type="ORF">CP523_07190</name>
        <name evidence="4" type="ORF">EI377_01945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673725.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01055"/>
    <dbReference type="EnsemblBacteria" id="AYE34250">
        <property type="protein sequence ID" value="AYE34250"/>
        <property type="gene ID" value="CP523_07190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59656">
        <property type="protein sequence ID" value="QAS59656"/>
        <property type="gene ID" value="EI377_01945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014260">
        <property type="entry name" value="Sulphite_reductase_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02911">
        <property type="entry name" value="sulfite_red_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="29776" checksum="ABC8F0B2962D628A" modified="2018-12-05" version="1">MSDNILTPKAYEIISVTKESKQEYTFRVATDIVPEHGQFLQLSIPKVGEAPISVSGFGPGYLDFTIRAVGKITDEIFNLQSGDEIFLRGAYGKGWPIEKFKGKNLVIVAGGTGVAPVRSMIKKLYNEPEYVESLNLVLGFKNEEGILFKNELEQWKDKFNTIYTLDNDEKDGWEKGLVTAHLKKLHLSSFYNNYEVVIVGPPVMMHFTALEFLKLGIPEDKIWVSFERKMSCAVGKCGHCRIDETYVCLEGPVFNYTKAKTLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET2</accession>
    <name>A0A386PET2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 12">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fabF</name>
        <name evidence="16" type="ORF">CP523_01240</name>
        <name evidence="17" type="ORF">EI377_11740</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02270"/>
    <dbReference type="EnsemblBacteria" id="AYE33176">
        <property type="protein sequence ID" value="AYE33176"/>
        <property type="gene ID" value="CP523_01240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61346">
        <property type="protein sequence ID" value="QAS61346"/>
        <property type="gene ID" value="EI377_11740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01240"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="15">
        <location>
            <begin position="5"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023971"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
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    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="411" mass="43933" checksum="16C1D20DFA7DEF78" modified="2018-12-05" version="1">MSRRVVITGVGAITPIGNDANSFWKNSKEGKLGIDFIKSIDNEILDVKVAGEVKDFNPEGILDKKEIKRLDKFVQYGIVACDEAIKNADLDLDKINKEKFGVLVGSGIGGFSTMENGFKVLFDRGAKRVSPLFIPMAIINLGAGNIAIKYGAKGMCNSAVTACATGTNNIGDAFRHIKHGYADVMIAGGTEAPITQMAIAGFNSMKALNSQNNPERASIPFDKERAGFVMGEGAGILVMESLEHAISRGANILAEIVGYGSTCDAYHITSPDPYGEGAARSMMQAIEEAGIDKNEISYINAHGTSTQLNDKFETAAIKKVFGEDSYNIPISSTKSMTGHLLGAAGAIESIVCINALIDGFIPPTIGYKVKDEELDLDYVPNIGRKVSLKYALTNSLGFGGHNASLVFKKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV2</accession>
    <name>A0A386PEV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01340</name>
        <name evidence="2" type="ORF">EI377_11840</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675572.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33196">
        <property type="protein sequence ID" value="AYE33196"/>
        <property type="gene ID" value="CP523_01340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61366">
        <property type="protein sequence ID" value="QAS61366"/>
        <property type="gene ID" value="EI377_11840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="65" mass="7157" checksum="D7E25119484194EC" modified="2018-12-05" version="1">MDNKKCIHCGKLINGNLIKDQSELGFWEAMATSINVMPGPGFTGTIPFISSFNNICPYCGKNILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF16</accession>
    <name>A0A386PF16_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate:ferredoxin (Flavodoxin) oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nifJ</name>
        <name evidence="14" type="ORF">CP523_02800</name>
        <name evidence="15" type="ORF">EI377_13325</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00966"/>
    <dbReference type="EnsemblBacteria" id="AYE33468">
        <property type="protein sequence ID" value="AYE33468"/>
        <property type="gene ID" value="CP523_02800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61639">
        <property type="protein sequence ID" value="QAS61639"/>
        <property type="gene ID" value="EI377_13325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="736"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="962"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="991"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="688"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="812"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="817"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1071"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1168" mass="127802" checksum="D2DB807512E42C1C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF36</accession>
    <name>A0A386PF36_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmF</name>
        <name evidence="5" type="ORF">CP523_00850</name>
        <name evidence="6" type="ORF">EI377_11345</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021875537.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02349"/>
    <dbReference type="EnsemblBacteria" id="AYE33102">
        <property type="protein sequence ID" value="AYE33102"/>
        <property type="gene ID" value="CP523_00850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61272">
        <property type="protein sequence ID" value="QAS61272"/>
        <property type="gene ID" value="EI377_11345"/>
    </dbReference>
    <dbReference type="GeneID" id="66301546"/>
    <dbReference type="KEGG" id="csep:CP523_00850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="6942" checksum="27DCE82326B7DCBA" modified="2018-12-05" version="1">MGNPARKTYRAKRDSRRAQTFKLSLPGIVECPQCHEMKLAHRVCKNCGFYKGKEVVASSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF82</accession>
    <name>A0A386PF82_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase</fullName>
            <ecNumber evidence="5">5.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">5-keto-4-deoxyuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">DKI isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kduI</name>
        <name evidence="6" type="ORF">CP523_03950</name>
        <name evidence="7" type="ORF">EI377_14475</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate</text>
            <dbReference type="Rhea" id="RHEA:23896"/>
            <dbReference type="ChEBI" id="CHEBI:17117"/>
            <dbReference type="ChEBI" id="CHEBI:29071"/>
            <dbReference type="EC" id="5.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the KduI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01560"/>
    <dbReference type="EnsemblBacteria" id="AYE33681">
        <property type="protein sequence ID" value="AYE33681"/>
        <property type="gene ID" value="CP523_03950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61838">
        <property type="protein sequence ID" value="QAS61838"/>
        <property type="gene ID" value="EI377_14475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03950"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008697">
        <property type="term" value="F:4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00687">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007045">
        <property type="entry name" value="KduI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027449">
        <property type="entry name" value="KduI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38461">
        <property type="entry name" value="PTHR38461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006625">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="276" mass="31784" checksum="9784C9C9FFC76416" modified="2018-12-05" version="1">MNNRYANHPEDSKKYTTSELRDHYLIEEIFIDDKIELTYSHVDRIIFGGIKPVYNELKLEAGKEMGVEYFLERRELGIINVGGPAIVTIDGEVYELNRRDGLYVGMGNKEVSFKSVNPKDPAKLYVNSVPAHHAYKTVKIEIEKANPVRLGDNSTLNKRTIYQYVHPNVCESCQLLMGLTMLEPGNAWNTMPCHTHERRMEVYFYFDMEEDTRVFHLMGEPTETRHLVVKNEQAIISPSWSIHSGVGTSNYTFIWGMCGENKTFDDMDAVSMETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF98</accession>
    <name>A0A386PF98_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="13">ACCase subunit beta</shortName>
            <shortName evidence="13">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="13">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">accD</name>
        <name evidence="15" type="ORF">CP523_01220</name>
        <name evidence="16" type="ORF">EI377_11720</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674370.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02274"/>
    <dbReference type="EnsemblBacteria" id="AYE33172">
        <property type="protein sequence ID" value="AYE33172"/>
        <property type="gene ID" value="CP523_01220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61342">
        <property type="protein sequence ID" value="QAS61342"/>
        <property type="gene ID" value="EI377_11720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01220"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041010">
        <property type="entry name" value="Znf-ACC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17848">
        <property type="entry name" value="zf-ACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="16" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="291" mass="32408" checksum="694B077DF68A9EC4" modified="2018-12-05" version="1">MLKDLFKKNQYATVSKVTFDTTEFDEKPNIPSGMWTKCDKCASMIYTEDLESNFNVCTKCGFHFRINAKERINQLFDKGSFKEFFYEIVTRNPLNFKGYEEKIKKGIVSSGNKEAVITGVGKINDIEIAVAIMDSYFMMGSMGSAVGEKITRIVELATDRNLPMVIFTTSGGARMQEGIFSLMQMAKVSAALAKHDDKGLLYITVLTDPTTGGVTASFAMEGDIILSEPNALIGFAGRRVIENTIKETLPDDFQSAEFLLEKGFVDAIVERKNLRGQLYKILCLHGGENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA1</accession>
    <name>A0A386PFA1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glyQS</name>
        <name evidence="10" type="ORF">CP523_08675</name>
        <name evidence="11" type="ORF">EI377_03425</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01676"/>
    <dbReference type="EnsemblBacteria" id="AYE34490">
        <property type="protein sequence ID" value="AYE34490"/>
        <property type="gene ID" value="CP523_08675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59892">
        <property type="protein sequence ID" value="QAS59892"/>
        <property type="gene ID" value="EI377_03425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="155"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="217"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="53404" checksum="BA4DFA669AD34CA1" modified="2018-12-05" version="1">MAVEKTMDKIVALCKNRGFIFPGSDIYGGLANSWDYGPLGVEFKNNVKKAWWKKFVQESPYNVGVDCAILMNKEVWVASGHIGGFSDPLMDCKDCKARFRADKLVEDHMTENGVEVASADGWSNEQLKEYIEKNNIVCPKCGKMNYTDIRKFNLMFKTFQGVTEDAKNEIYLRPETAQGIFVNFKSVQRSSRKKVPFGIAQIGKSFRNEITPGNFTFRTREFEQMELEFFCKPGTDLEWFGYWKDYCWKFLLNLGAKEQNLRMRDHAQEELSFYSNATSDIEYLFPFGWGELWGIADRTDYDLTKHQEHSGQDMSYLDPTNNEKYVPYVIEPSLGADRVALAFLVDAYDEEELEGGDIRTVMHLHPALAPYKAAILPLSKKLSEKALEVYEDLSKKFNLEYDDAGSIGKRYRRQDEIGTPYCITIDFETLEDNAVTIRDRDTMKQERIKIEDLEAFIAKSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH5</accession>
    <name>A0A386PFH5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06865</name>
        <name evidence="7" type="ORF">EI377_01340</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00038"/>
    <dbReference type="EnsemblBacteria" id="AYE34197">
        <property type="protein sequence ID" value="AYE34197"/>
        <property type="gene ID" value="CP523_06865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59561">
        <property type="protein sequence ID" value="QAS59561"/>
        <property type="gene ID" value="EI377_01340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036244">
        <property type="entry name" value="TipA-like_antibiotic-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012925">
        <property type="entry name" value="TipAS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07739">
        <property type="entry name" value="TipAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89082">
        <property type="entry name" value="SSF89082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="29855" checksum="8C4A2A4A634B0C0B" modified="2018-12-05" version="1">MYKIKEVATMAGISVRTLHYYDEINLLKPNFINKSGYRVYSKDDIERLHQILFFKELSFSLNEIKNIVNNPNFDKVEVLKIQKELLLRKSNRLDEIINSISDILSNSNNSLDYNERFKVFNMKEIEEFKKKYEKEVREKYPKKIVDECNKKTNKYNKDDWKKIQDNADEIFNSLAKLMDSNPSCEEVQNLIEEYRNHITSNFYQCTIEIYRGLGELYVTDERFIKFYDKYKKGLANFIKEAIDIYCNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL9</accession>
    <name>A0A386PFL9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02790</name>
        <name evidence="3" type="ORF">EI377_13315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676979.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00964"/>
    <dbReference type="EnsemblBacteria" id="AYE33466">
        <property type="protein sequence ID" value="AYE33466"/>
        <property type="gene ID" value="CP523_02790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61637">
        <property type="protein sequence ID" value="QAS61637"/>
        <property type="gene ID" value="EI377_13315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="274" mass="31152" checksum="FC7C91E028808134" modified="2018-12-05" version="1">MKYADLHIHSNYSDGAKTPEEIIEIAKQNNVKCISITDHDCIKAQYVTKNTYNDIEVIPGIELSTEYKDLELHILGYFIDIENSTLKDVVNKLNKSRSDRIEEILLQLKKNNIHLSLEELAVDINSTLGRSHVANAMVKKGYFDNYKTAFTSFLVKGKPAYVKGFKLDYKKTIDVINKAGGIAVLAHPGQIYRGMDVEKIIKDLKCYGLKGIEVYHPSHSKCQINNFYNLSKKYKICITGGSDYHGKELIHDTRIGSYGINELLLNKIYNLKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY7</accession>
    <name>A0A386PFY7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ylqF</name>
        <name evidence="5" type="ORF">CP523_00780</name>
        <name evidence="6" type="ORF">EI377_11275</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674617.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02364"/>
    <dbReference type="EnsemblBacteria" id="AYE33089">
        <property type="protein sequence ID" value="AYE33089"/>
        <property type="gene ID" value="CP523_00780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61258">
        <property type="protein sequence ID" value="QAS61258"/>
        <property type="gene ID" value="EI377_11275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="4">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="295" mass="33516" checksum="8AF51318D9D6CCFA" modified="2018-12-05" version="1">MATINWFPGHMKKTQREIKENLKLVDAVIEIRDARIPRSSANPDIDKLCGDKPRIILLNKSDLIEQKVMKMWIKHLTSENVKVIEANCITGKGLNQIKPTLDALLKEKHDRLKSKGLVKIQVRVMVVGIPNVGKSTFINKMARNNIAKTGDRPGVTKSKQWIKTKMDIEMMDTPGVLWPKFEDENTALNLAFTGAIKDEIMDIEELAYLLVKKLQVHNAENLKERYKIEEVNEEPLETLNSIARKRGCLIKGGEINYNRIAVILLDEFRGGKIGNIALERPDDILEDDEKSEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG16</accession>
    <name>A0A386PG16_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10120</name>
        <name evidence="3" type="ORF">EI377_04920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676602.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00353"/>
    <dbReference type="EnsemblBacteria" id="AYE34730">
        <property type="protein sequence ID" value="AYE34730"/>
        <property type="gene ID" value="CP523_10120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60131">
        <property type="protein sequence ID" value="QAS60131"/>
        <property type="gene ID" value="EI377_04920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="22939" checksum="F0EB360BF1C8CAD9" modified="2018-12-05" version="1">MRLKKAIKKENGRKKRFLIFMIVISIFLPAVVYFYKIRSTFILSYLGVIEFLIAIAVLAKVNYHKLDFKCSNNKLEMKNSLFLKKNLLLCDKVALVHTDKYKEEMEIIIITTVGFKNTSLSPVTGGFLKRYPEAGEKYLKIKKMNPENMYYFKIIKRGGFKKYQLLDVIYRNCVKAVYTSSAIESIKLAREQNEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG52</accession>
    <name>A0A386PG52_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33991">
        <property type="protein sequence ID" value="AYE33991"/>
        <property type="gene ID" value="CP523_05675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032721">
        <property type="entry name" value="Toxin-deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14424">
        <property type="entry name" value="Toxin-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="169" mass="19320" checksum="F6F6D03E7E9BE14C" modified="2018-12-05" version="1">MGNLLRDESKVVRTKLYDSITTFKNSDEYINLSNTQRKKIDRRIDKLELGNVATADVNIPGIKKEFSAHSQIHSIDSLGADVMDFSYTPAESERIFKNYVVDEFPRYNDTEAKILEDIASKIKDKNIKGEVNLFTELDTCQSCTNIILEFRATYPNIKLNIFTNNTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG59</accession>
    <name>A0A386PG59_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01687"/>
    <dbReference type="EnsemblBacteria" id="AYE33868">
        <property type="protein sequence ID" value="AYE33868"/>
        <property type="gene ID" value="CP523_04950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017457665" evidence="5">
        <location>
            <begin position="36"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="637"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131322" checksum="B28403E2C72DA1B8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG66</accession>
    <name>A0A386PG66_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-type small acid-soluble spore protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Small, acid-soluble spore protein, alpha/beta type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11755</name>
        <name evidence="5" type="ORF">EI377_06575</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876337.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02910"/>
    <dbReference type="EnsemblBacteria" id="AYE35033">
        <property type="protein sequence ID" value="AYE35033"/>
        <property type="gene ID" value="CP523_11755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60427">
        <property type="protein sequence ID" value="QAS60427"/>
        <property type="gene ID" value="EI377_06575"/>
    </dbReference>
    <dbReference type="GeneID" id="66302341"/>
    <dbReference type="KEGG" id="csep:CP523_11755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="6485" checksum="64AED40B04DB6381" modified="2018-12-05" version="1">MAKTLVPEAKNGLAKFKNEVASEMGVPFTDYNGDLSSKQCGSVGGEMVKRMVQQYESGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG90</accession>
    <name>A0A386PG90_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10520</name>
        <name evidence="3" type="ORF">EI377_05305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674195.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01396"/>
    <dbReference type="EnsemblBacteria" id="AYE34800">
        <property type="protein sequence ID" value="AYE34800"/>
        <property type="gene ID" value="CP523_10520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60195">
        <property type="protein sequence ID" value="QAS60195"/>
        <property type="gene ID" value="EI377_05305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="297" mass="34752" checksum="0A2AAB5CD9F6A60E" modified="2018-12-05" version="1">MAFIIIDLEFNNLSGITKYYPNIYDEYANLKDIEVENEIIEIGAIKLDNYMKPLEEFKTYIKPTIFPILNPKVSEITNITDKDLQNGVSFKEGINNLRNIIEDGDIICSWAKDDIAQIISNAIYHKYDDLSWINNYLDIQEYSTKILAKKKVLSLKKALEELKIKIDKKNLHDALNDAIYTSFVFKRIYNSRIIRNYIIKDLYNMPVLEVKNLSDFNIDKSCVKEYCPKCKIKIDIEIPLKAMGWRFVSLGKCPKCNNRVINEVQVKKTISGKVVYKEISTIINEVEYMNYYYKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG93</accession>
    <name>A0A386PG93_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12035</name>
        <name evidence="3" type="ORF">EI377_06860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02964"/>
    <dbReference type="EnsemblBacteria" id="AYE35085">
        <property type="protein sequence ID" value="AYE35085"/>
        <property type="gene ID" value="CP523_12035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60478">
        <property type="protein sequence ID" value="QAS60478"/>
        <property type="gene ID" value="EI377_06860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017342">
        <property type="entry name" value="S-AdoMet-dep_Met_synth_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037984">
        <property type="entry name" value="Met_synth_TM0269_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="SSF56507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="27286" checksum="FE704F6B8D4F4543" modified="2018-12-05" version="1">MNNKVKEFEINKEEVLRYLGYRGQEINEEINEEINNIIEECRNEVKKLVNPRYIYKFYNVFRKDNEINIKNSTLVLKGKDIKKHLVFSDTCVLMAATIGSDVERKINLYERINLTKALVMDACATTAIEELCDYIEKEIRDIVRRKCKNLNFRFSPGYGDLDIEIQKEFIKVIEANKKIGLTASSNNILFPRKSVTAIIGIINEDKFVKKRRCLECRNYNNCNFRKEGFNCGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF5</accession>
    <name>A0A386PGF5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12400</name>
        <name evidence="3" type="ORF">EI377_07285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675346.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02033"/>
    <dbReference type="EnsemblBacteria" id="AYE35155">
        <property type="protein sequence ID" value="AYE35155"/>
        <property type="gene ID" value="CP523_12400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60558">
        <property type="protein sequence ID" value="QAS60558"/>
        <property type="gene ID" value="EI377_07285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="276" mass="32505" checksum="8AC507AABF3B62F1" modified="2018-12-05" version="1">MEQELYSIGKVGEICKITPKALRYYDKMGVLSPNKVSNDNGYRYYSKKNLLAVPVIKYYKQSGFKLEEMKEFLEGTTYDFFDKRFRSKIDELGELEKEINLKKRSVKDWHDLIVEAQMVIENNACDVSVKYIDNKTVTFFNQGFKYDYMDSIINIEFSNYIDNMNNAVTGPVIICFPSFRDKVQGKCDKVKIMQQTILKCREEVTEEFGGWMAVACYHIGAHETINETYKKMEKWSKDHGYICCDESYERYVTDYWTTKNTDKFVTEILIKIKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM9</accession>
    <name>A0A386PGM9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glycosidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06785</name>
        <name evidence="4" type="ORF">EI377_01260</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01458"/>
    <dbReference type="EnsemblBacteria" id="AYE34191">
        <property type="protein sequence ID" value="AYE34191"/>
        <property type="gene ID" value="CP523_06785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59555">
        <property type="protein sequence ID" value="QAS59555"/>
        <property type="gene ID" value="EI377_01260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="139"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="608" mass="71842" checksum="E1FA38679C29887D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ5</accession>
    <name>A0A386PGQ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_11355</name>
        <name evidence="7" type="ORF">EI377_06175</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673255.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34960">
        <property type="protein sequence ID" value="AYE34960"/>
        <property type="gene ID" value="CP523_11355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60355">
        <property type="protein sequence ID" value="QAS60355"/>
        <property type="gene ID" value="EI377_06175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01046">
        <property type="entry name" value="Rubrerythrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045236">
        <property type="entry name" value="Rubrerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="51"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="19864" checksum="DD3CABB7E34CA51E" modified="2018-12-05" version="1">MKKFVCTVCGYVHEGDAAPEKCPLCQVGADKFVEQSGDLAWADEHRVGVAKDVDPRIMEGLQANFMGECTEVGMYLAMSRQADREGYPEVAEAYKRIAWEEAEHAAKFAELIGEVVAADTKANLQARVNAEHGACQGKKELATLAKQLNLDAIHDTVHEMCKDEARHGMAFSGLLNRYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR5</accession>
    <name>A0A386PGR5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(2Fe-2S)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08180</name>
        <name evidence="3" type="ORF">EI377_02935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674688.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01579"/>
    <dbReference type="EnsemblBacteria" id="AYE34404">
        <property type="protein sequence ID" value="AYE34404"/>
        <property type="gene ID" value="CP523_08180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59810">
        <property type="protein sequence ID" value="QAS59810"/>
        <property type="gene ID" value="EI377_02935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_BFD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="7868" checksum="CC1B6AD400F5E7DB" modified="2018-12-05" version="1">MENKLNEQVLDKITKVCTCKAIPRSKIKDAINAGAHTVEEVSKATGACTGGCRGYRCTPTIEKLIKTHLENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU8</accession>
    <name>A0A386PGU8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flgG</name>
        <name evidence="5" type="ORF">CP523_02495</name>
        <name evidence="6" type="ORF">EI377_13030</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673949.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00468"/>
    <dbReference type="EnsemblBacteria" id="AYE33409">
        <property type="protein sequence ID" value="AYE33409"/>
        <property type="gene ID" value="CP523_02495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61583">
        <property type="protein sequence ID" value="QAS61583"/>
        <property type="gene ID" value="EI377_13030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="183"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="256" mass="28412" checksum="E05A8866E4A52CA7" modified="2018-12-05" version="1">MIRSLYTSVSGLISLENRQSNINNNMANANTTGFKGDNLAIKSFDEVMLQNRDKVSGNKNVTQKLGTLSLGAKIDSVDTMFTQGMLKSTNKPSDFAIDGRGFFAVKRGNETLFTRDGNFKVDNDGYLVNLSRDKVLGVNKTTGAMEPIFVGNNKFDLDKYNNLNIGGKITHTLSTADFEDYSKLKKIGDNYYRGDNPVYNARVTVKQGYLEASNINIANEMVEMMTTMRNFETNQKMIQTIDETLGKAANEVGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW3</accession>
    <name>A0A386PGW3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_11660</name>
        <name evidence="7" type="ORF">EI377_06480</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35020">
        <property type="protein sequence ID" value="AYE35020"/>
        <property type="gene ID" value="CP523_11660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60414">
        <property type="protein sequence ID" value="QAS60414"/>
        <property type="gene ID" value="EI377_06480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="469" mass="51908" checksum="7F48E53BF933242E" modified="2018-12-05" version="1">MGIDNKLFTSEKISKAILKLALPITISLFVSELYNMVDTIFVGRYIGPNAIGALTVAFPIQRLLISLGLLIAVGTSTFMSRSLGEKNFKSLRKSLITSLTTTILLLTSVSLLIFFFKKPIISALGASDTLYPLAKEYIIIILVGGVFQCIGVVLSYVMTALGNAKITLYSNSLGALINIVIDFILVAKLDMGVKGAAIATVISQIIALIYVLYSFYKVREIFALKNSTNYSIISTQSFKNDFNIGILISIISIGFSSFIIEISDAIVAIILNNILYSHGGDNAIIIVGVITKVSMFMFITIIGISSAIQPIIAYNHGCGNKIRIKEVLKMGGLYLIITSFILWSILMIFANSILSCFLTDTYLLPIAIKAFRICISLLPTVCIYYMCIYYYQAINEAKLSFILSIYRQLILFIPLAFILVRYIGITGAWIAYPISDIISAITSLYFMKKTKISKTKYKISYKKAIFDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH03</accession>
    <name>A0A386PH03_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09705</name>
        <name evidence="9" type="ORF">EI377_04505</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34677">
        <property type="protein sequence ID" value="AYE34677"/>
        <property type="gene ID" value="CP523_09705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60078">
        <property type="protein sequence ID" value="QAS60078"/>
        <property type="gene ID" value="EI377_04505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="326"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="420" mass="48867" checksum="BE7CEB251F863D67" modified="2018-12-05" version="1">MKNKSITKLFINKNFFVNLFIILELSLLILFIYTIQTEIRVKKYVDNLDNYYWNSGNSYSIYLNPEEFHNNSGDLGLKINDFYNKLKSSNKIEDIGLIYTSNGDTSKLSKECRDYIYIPYSKLGEILHNQFDNDTGLMPIRFVNYDYIKGMNINVETGSIFTKEEQKESTNYTILGHKFRKFFNLNEKIQVDNYDMIVKGIGKQDIPFFFDKDYAEAYPFLDNSMIILINSDMMNNLNFIREAFLKGGLNIKFKDDKVDGNKEYVRKLAIESGLDIGMRNNFIMYEDATKVIKSEIKFSFIRTIIFLFSSLIAISTINIYTIYDFKKEFGIMISLGAKKIDIFKIVFIKNTIITILAFTLGTILSYKIKLAGNGWYAVDIKIINILISFFILIIIMSLSMLMPIYKILKIESRELIGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH82</accession>
    <name>A0A386PH82_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS ascorbate transporter subunit IIB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">PTS sugar transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05240</name>
        <name evidence="4" type="ORF">EI377_15800</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676251.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01837"/>
    <dbReference type="EnsemblBacteria" id="AYE33922">
        <property type="protein sequence ID" value="AYE33922"/>
        <property type="gene ID" value="CP523_05240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62073">
        <property type="protein sequence ID" value="QAS62073"/>
        <property type="gene ID" value="EI377_15800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="96" mass="10529" checksum="81E0B8CF6E1EE373" modified="2018-12-05" version="1">MLKVIAACGNGMGSSQIIKMKIEKIFRKLGVQVSIHHSSVGEAKTQASNYDVVFCSEALKGNFANAEKNGTKIIGLKNLLSEQEIEEKIKEHVIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH93</accession>
    <name>A0A386PH93_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07245</name>
        <name evidence="5" type="ORF">EI377_02000</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673743.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01066"/>
    <dbReference type="EnsemblBacteria" id="AYE34258">
        <property type="protein sequence ID" value="AYE34258"/>
        <property type="gene ID" value="CP523_07245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59665">
        <property type="protein sequence ID" value="QAS59665"/>
        <property type="gene ID" value="EI377_02000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="325" mass="36477" checksum="8B64764DFBB00606" modified="2018-12-05" version="1">MANSGTIRNININNIRKALGANESISKSDLAKYIGLSFPTVSNTIEYLIKKNEVIEVGIQDSLGGRCAKKYSLNPMYALSLSLYLEGFKLCWIVNDFCENKIESGSVICKSDILMEIDKVVSLIKSKYPQLASIMIGVASNVNDGKIISEMEYIELQGVDIVKYFKDKYDIPVNIENDMNVAAIGYWERHENNDIEAVVSIYMGENGVGSSLVINGKVWGGASNFAGEIHYLPICEDNKIYPICGFRDINIVEYYGNIIQSYIALVNPNLIVLYNNSYIENKLDEIKNYCKSRVPRIVIPEIIISNEFRADYEYGLNSMANELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH98</accession>
    <name>A0A386PH98_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12475</name>
        <name evidence="5" type="ORF">EI377_07360</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675319.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02018"/>
    <dbReference type="EnsemblBacteria" id="AYE35170">
        <property type="protein sequence ID" value="AYE35170"/>
        <property type="gene ID" value="CP523_12475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60573">
        <property type="protein sequence ID" value="QAS60573"/>
        <property type="gene ID" value="EI377_07360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="3">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="24842" checksum="63918E42E9F90484" modified="2018-12-05" version="1">MYALGLIETKGLLPAIEAADVMVKSADVSIVEKSYVGGALVTILIKGDVAAVKAAIEAGAAAVKKIDERYLISEHVIPRPHEELDGIIGPNTPDNSQSEKEDNLEESEEELESFEEVSKETKDHIENIEEAKEILEEHQEVLDVDLDKQKGVNLEDLHKEDVDNLVNNDGIEKTILTLSKLKVVKLRNLAREYNDFVIKGRSISKADKNLLLTKFRLYYYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA6</accession>
    <name>A0A386PHA6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10385</name>
        <name evidence="3" type="ORF">EI377_05155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674249.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34777">
        <property type="protein sequence ID" value="AYE34777"/>
        <property type="gene ID" value="CP523_10385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60173">
        <property type="protein sequence ID" value="QAS60173"/>
        <property type="gene ID" value="EI377_05155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="113" mass="12956" checksum="9174023418C57821" modified="2018-12-05" version="1">MKKFAAILNKTINILLIFFVVFLILNEYYIVEFSKTLRNVFAFLTFILILISAMKELLTNKSGLSRFINGIILFCSIIGGVFSVISNQLNLFIYICILFSVSYGFIDLVYKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB7</accession>
    <name>A0A386PHB7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coproporphyrinogen III oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14230</name>
        <name evidence="7" type="ORF">EI377_09135</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678497.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00276"/>
    <dbReference type="EnsemblBacteria" id="AYE35495">
        <property type="protein sequence ID" value="AYE35495"/>
        <property type="gene ID" value="CP523_14230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60881">
        <property type="protein sequence ID" value="QAS60881"/>
        <property type="gene ID" value="EI377_09135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023995">
        <property type="entry name" value="HemZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF1">
        <property type="entry name" value="PTHR13932:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00310">
        <property type="entry name" value="oxygen-independent_coproporphy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03994">
        <property type="entry name" value="rSAM_HemZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="140"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="474" mass="54890" checksum="B6C4E13B409BBF4C" modified="2018-12-05" version="1">MEVKISLNDLKYRYDVYQMFNIYFPLHELKFVDDGEYIVNIDIENIEFKFKGFYNKIQISENIKEDIKRLIFLSLKELTGVHYPWGILVGIRPSKIALKYLQEGKSEDEIIEIFKVKHLASEEKAKLCIEVAKKEEKFVNKKEKNISVYIGMAFCPTRCFYCSFAANPIGGNKKLVPTYLESLTYEIREMKKYVESRKLNIETVYFGGGTPTSVNNEEFENIMKEIYNAFIQGKNVVEFTVECGRPDSITEEKLLTMKKYNTTRISINPQTMNDETLSMIGRGHTSSDVIEKFNLARELGFKDINMDMIIGLPGEGLKEAKHTANEILKLSPDSLTVHGLSLKRASILYENFILKKGIQIKEQVELASMYEESRTLAKELSLEPYYMYRQKNMVGNMENLGYSKVSKECIYNIQMIEDKQTIIALGADAVSKVVFLEENRIERFANIKDVREYTSRIKEMVEGKQKLLDSLYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD1</accession>
    <name>A0A386PHD1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05760</name>
        <name evidence="2" type="ORF">EI377_00225</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34006">
        <property type="protein sequence ID" value="AYE34006"/>
        <property type="gene ID" value="CP523_05760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59375">
        <property type="protein sequence ID" value="QAS59375"/>
        <property type="gene ID" value="EI377_00225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="70" mass="8379" checksum="E33F17515350E28B" modified="2018-12-05" version="1">MVYCPFCDGQGVIYKAKIKETQIEIYICDECDTVWRDRNIKEDNCERFKDIMNKIGYKGLWSELTDEEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD6</accession>
    <name>A0A386PHD6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14340</name>
        <name evidence="2" type="ORF">EI377_09250</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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    <dbReference type="EnsemblBacteria" id="AYE35515">
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000288332"/>
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    <sequence length="310" mass="34812" checksum="3A453D57F229CDA0" modified="2018-12-05" version="1">MTSIDLHCDTASRLLYENLSLNKSICKVDIEKLRKSKALAQVFANFIELNIVDNPYEEFKKMYNNFIGEIDKNAKNIVIVRNLSELENANANGKIGAFLAIEEGEVLEGKVERVKEMYNLGIRFITLTWNFKNSIGYPNGDYKYKDKGLTEKGKEIVNEMERLGIIPDCSHLSDGGFYDLVNICKKPFIATHSNARAVTNHPRNLTDDMIVKLSNKGGVMGLNFCAPFLGDKEIPDMLEMIAHLKHVKNVGGIDVLALGTDFDGIENEVEIKNIGEIGKLSQALIKEGFKESEIDKIFFGNVKRVIKECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
            </authorList>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <sequence length="100" mass="11811" checksum="0E91DBD446DEF39E" modified="2018-12-05" version="1">MINKVKLIISDRSKLHDEDDYNIEICRERLIEILSKDEESTILILNELNEKEILLASEVFEEVAYNLQSNRYIECLKSISLKYPNLNLEESIEVAEEYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI2</accession>
    <name>A0A386PHI2_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CP523_14625</name>
        <name evidence="3" type="ORF">EI377_09590</name>
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    <reference evidence="4" key="1">
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                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
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    </reference>
    <reference evidence="2" key="2">
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <end position="25"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE35565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7932" checksum="7AD1942FD63D7BC5" modified="2018-12-05" version="1">MKKRINLLIIITLLILLIFVFIIYFKQPTIIFENKSKVQTESTLKTFSNEGITIKEINLSTLRDSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL9</accession>
    <name>A0A386PHL9_CLOSE</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09690</name>
        <name evidence="3" type="ORF">EI377_04470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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            <end position="23"/>
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            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="275" mass="32630" checksum="8EB958B876F660DC" modified="2018-12-05" version="1">MQSIPIWQYLLSMFIYTTFLYIMVELARKYLRITTIVGILILFTFPLWLKTFGNDWFRLGKVLIVLIPTCFVNILRINNKYKNKGLKFLKQNWVLWFLYVVLFCNILEASIKDLTLGNYYNFIAGILCCITIPIPTKNWRFGAKEGFGELICDLPLMWCLLYTTWNMGFVYAENTGFFASSLCILVVPEIYSIIRKRSDLWLHARVYTLAIHMFIRATFGDIFNPIMGSISWRNEYIIPWIGIFNMIFAILYTLWWFKKLSLDKKEKKSYFITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT5</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="ORF">EI377_01085</name>
    </gene>
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                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE34166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677483.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34166">
        <property type="protein sequence ID" value="AYE34166"/>
        <property type="gene ID" value="CP523_06595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59534">
        <property type="protein sequence ID" value="QAS59534"/>
        <property type="gene ID" value="EI377_01085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06595"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="101" mass="11298" checksum="BF8E04F427276277" modified="2018-12-05" version="1">MRGSTIVMIMASIGFILIGLVILSSKKIKSLMSDVKIYTDTKKFISFNGMFNIGIGVIGLLLGSLDYFYAELSKYIVIVFIIIMVTASLIQNKLSKKYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT9</accession>
    <name>A0A386PHT9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrichrome ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Iron-hydroxamate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08405</name>
        <name evidence="4" type="ORF">EI377_03150</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674792.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01622"/>
    <dbReference type="EnsemblBacteria" id="AYE34448">
        <property type="protein sequence ID" value="AYE34448"/>
        <property type="gene ID" value="CP523_08405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59851">
        <property type="protein sequence ID" value="QAS59851"/>
        <property type="gene ID" value="EI377_03150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362722" evidence="1">
        <location>
            <begin position="25"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="34891" checksum="52C64197631BA003" modified="2018-12-05" version="1">MKIKLLKTLVVSCMAAMVLVGCGGKGNSENDKVAGDTITVTDVRGEVEIPVNPKRIVDLSGNSDILSILGYKVIGTANSDAYDYTKFPSYLEETLKGAEILGYSMQDTMDVEAIMNLSPDLIVISTVQEKMYDQLSEIAPTVMIQLEALNWKDDIRAFAKVFNKEDEANKWLENYEAKAKEAGDKIKEEYSDNATYLSFLASGGQFFVFDGAGFGSVLYEDMGLAKPEGMPKQNDISLPVVTYEGLASIKADYIFLIATKEDLEQLENNAIWNSLPAVKNGNVVILDSSPYFNQGYSSIGRELLVDKIGEMLNETKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU5</accession>
    <name>A0A386PHU5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9 11">Uracil-DNA glycosylase</fullName>
            <shortName evidence="9">UDG</shortName>
            <ecNumber evidence="4 9 11">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ung</name>
        <name evidence="13" type="ORF">CP523_06670</name>
        <name evidence="14" type="ORF">EI377_01135</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9 11">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 11">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 9 11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00037"/>
    <dbReference type="EnsemblBacteria" id="AYE34176">
        <property type="protein sequence ID" value="AYE34176"/>
        <property type="gene ID" value="CP523_06670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59539">
        <property type="protein sequence ID" value="QAS59539"/>
        <property type="gene ID" value="EI377_01135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="12">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS59539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="225" mass="25971" checksum="43CBD77316672742" modified="2018-12-05" version="1">MKKILDNDWQELLESEFQKEYYQDLRKFLIYEYKTKTIYPNMYDIFNALKFTSYKDVKVVIIGQDPYHGPNQAHGLSFSVNKGIKTPPSLLNIYKELNSDLGCYIPNNGYLKKWADQGILLINTVLTVRAHEANSHKNMGWEIFTDKIISLLNGKDDPIVFILWGNPAIKKSLLITNKNHFILKSPHPSPLSASRGFFGSRPFSKTNEILKFIGKSPIDWQIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI22</accession>
    <name>A0A386PI22_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_07140</name>
        <name evidence="9" type="ORF">EI377_01885</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673712.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01043"/>
    <dbReference type="EnsemblBacteria" id="AYE34242">
        <property type="protein sequence ID" value="AYE34242"/>
        <property type="gene ID" value="CP523_07140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59647">
        <property type="protein sequence ID" value="QAS59647"/>
        <property type="gene ID" value="EI377_01885"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006304">
        <property type="term" value="P:DNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
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        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
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        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="7">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="167"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="169" mass="19453" checksum="6FD94A2FC521C209" modified="2018-12-05" version="1">MAVTLEKSLLFYDNLHTPIGNICIIMDEKGVRKIEIIEEQWCKFLNLNSDIKLDKNRCKDVKNQIDEYFRGERKSFNIPISINSTRFRQQVWKELSKIPYGETKSYSEIANNIGNPRAVRAIGQANRGNPLPIIIPCHRVISKSGALIGYAGNYTNIQKILLDHEKVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI36</accession>
    <name>A0A386PI36_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04750</name>
        <name evidence="3" type="ORF">EI377_15260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01722"/>
    <dbReference type="EnsemblBacteria" id="AYE33829">
        <property type="protein sequence ID" value="AYE33829"/>
        <property type="gene ID" value="CP523_04750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61975">
        <property type="protein sequence ID" value="QAS61975"/>
        <property type="gene ID" value="EI377_15260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="677" mass="77050" checksum="EDB978E722513435" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI73</accession>
    <name>A0A386PI73_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673420.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35047">
        <property type="protein sequence ID" value="AYE35047"/>
        <property type="gene ID" value="CP523_11830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="113" mass="13453" checksum="053ABA30B6C50C16" modified="2018-12-05" version="1">MKELFKVKDLVFYKEDFLDDINEYEDILPIIQELSSNLDYEKIEVVDLNDCCEETKENYIVEIPGFLNEEDEFLTKEEVMKTGEIPKGKILDLFVIRIYKCTKCSKWIIDILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI79</accession>
    <name>A0A386PI79_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRR_adjacent domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_04955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the internalin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01686"/>
    <dbReference type="EnsemblBacteria" id="AYE33869">
        <property type="protein sequence ID" value="AYE33869"/>
        <property type="gene ID" value="CP523_04955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012569">
        <property type="entry name" value="LRR-contain_adjacent_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08191">
        <property type="entry name" value="LRR_adjacent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017345459" description="LRR_adjacent domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="LRR_adjacent" evidence="7">
        <location>
            <begin position="337"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="643"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="711" mass="80731" checksum="C25D3C9D76B2005B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI81</accession>
    <name>A0A386PI81_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sporulation integral membrane protein YtvI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ytvI</name>
        <name evidence="7" type="ORF">CP523_07595</name>
        <name evidence="8" type="ORF">EI377_02285</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01128"/>
    <dbReference type="EnsemblBacteria" id="AYE34316">
        <property type="protein sequence ID" value="AYE34316"/>
        <property type="gene ID" value="CP523_07595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59710">
        <property type="protein sequence ID" value="QAS59710"/>
        <property type="gene ID" value="EI377_02285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014227">
        <property type="entry name" value="YtvI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02872">
        <property type="entry name" value="spore_ytvI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="373" mass="42026" checksum="FCD8654B9E555393" modified="2018-12-05" version="1">MKFLRRELKLLDKDTNLNDNYKFQDKISKLVLFFTIYTLSFVFFTSTIKFTLPFILAGIFALILKSPTKYLIKKIKMKSWLASLASTIIFFSLFIFILILAISSLTSELVSVAKTLQEFLSSNSSSYFSELGSFFQNIVDNLNLIDPSVWNNIVKTATESLNKFLQLGVSGVTSLITGLFSFFGYVPYIGMVIAFTLLSTYFFTEKVATASSDKFNNLIPLGNKKIFNAIKHGKKMIANYLLAYMFLIFLSMFITFIGFLIFKIDYALLLSILAGLLDLLPIVGMACVYIPLILYFLYQGNLFVAIGLVILYLLVFVSRQLLEPKIMSSSLGISPISTLAAMFIGLQLNGLMGMVFCMLLVVCYTILKRVEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB9</accession>
    <name>A0A386PIB9_CLOSE</name>
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        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_12285</name>
        <name evidence="9" type="ORF">EI377_07110</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03013"/>
    <dbReference type="EnsemblBacteria" id="AYE35865">
        <property type="protein sequence ID" value="AYE35865"/>
        <property type="gene ID" value="CP523_12285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62172">
        <property type="protein sequence ID" value="QAS62172"/>
        <property type="gene ID" value="EI377_07110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
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    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="138"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="265" mass="30487" checksum="5A907AA4804D9CD7" modified="2018-12-05" version="1">MVHGDIERNDNELWFLVNNGQLLVKVDGDYMKIPYFKDIKNLNLDFNKGYCLGEFKDGICFGIEINEDIEINEDLKIISLYEAGIILEEELFFIAGRANQIIHWDKTHKFCGKCGSETKNKEDEKAKICTKCNFVTYPVISPAIIVAITKEDEILLAHNKGFKDNKYGIIAGFVDPGESLEECVKREVFEEVGIKIKNIKYYDSQIWPFPNSLMIGFFAEYESGEIKVDGKEIVKAGWFKKDNFPKIPDKMSIARKMIDYFAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE0</accession>
    <name>A0A386PIE0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-ribulose-5-phosphate 3-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.22</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05225</name>
        <name evidence="3" type="ORF">EI377_15785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.22" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676245.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01834"/>
    <dbReference type="EnsemblBacteria" id="AYE33919">
        <property type="protein sequence ID" value="AYE33919"/>
        <property type="gene ID" value="CP523_05225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62070">
        <property type="protein sequence ID" value="QAS62070"/>
        <property type="gene ID" value="EI377_15785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034015">
        <property type="term" value="F:L-ribulose-5-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004560">
        <property type="entry name" value="L-Ru-5P_3-Epase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00542">
        <property type="entry name" value="hxl6Piso_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="283" mass="32413" checksum="6BC6AB37C60CE263" modified="2018-12-05" version="1">MKEYTLGLYEKSMPNTLTWKEKLTCAKEAGFDFVEISIDETEEKLSRLCMSKEERFELVKTMCEVGIPIRTMCLSGHRKFPLGSLDESVRNRGMEIMEKAVELACDLGIRIIQLAGYDVYYDESTEETKKLFAKNLKIAVEMAAKKGIILAFETMETEFMNTVEKAMKYVNNVNSPYLQVYPDCGNITNAAVAYNKNVLDDLKTGKGHIAAVHLKETVPGKFREIPFGTGHVNFEDIIKTSWDLGVRRYVAEFWYVGNDNWKETLKETKSFMDEKFKKAHTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE6</accession>
    <name>A0A386PIE6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08060</name>
        <name evidence="6" type="ORF">EI377_02820</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675944.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00727"/>
    <dbReference type="EnsemblBacteria" id="AYE34382">
        <property type="protein sequence ID" value="AYE34382"/>
        <property type="gene ID" value="CP523_08060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59788">
        <property type="protein sequence ID" value="QAS59788"/>
        <property type="gene ID" value="EI377_02820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="243" mass="27413" checksum="3FBC02F56A321668" modified="2018-12-05" version="1">MLQLKNVTKKFKKTIVVDNISFDVNEGEIVGLLGENGAGKTTTLRMISTMLQISNGDIFVNNIDVKKYPEKVRKEIGILFGGDVGLYDRLTGKENIRYFANLYGMSKAEADRRIDELSKSFGMEEYINKPVGKYSRGMKQKISIARSIVHNPSIMLFDEPTTGLDVSAARIVQNFILQCKKENKVILFSSHSMKEVEKLCDRVVIINKGKLLEDSTILNLKEKHNNNDLEEMFLDLIGGSLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH1</accession>
    <name>A0A386PIH1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12410</name>
        <name evidence="2" type="ORF">EI377_07295</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675344.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02031"/>
    <dbReference type="EnsemblBacteria" id="AYE35157">
        <property type="protein sequence ID" value="AYE35157"/>
        <property type="gene ID" value="CP523_12410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60560">
        <property type="protein sequence ID" value="QAS60560"/>
        <property type="gene ID" value="EI377_07295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="88" mass="10125" checksum="0D2506D05F3BF887" modified="2018-12-05" version="1">MKPLNYAILKHFTKVEEACADDIIEALKGEYGNFKAFKKQSIINALMTAEANGLIEETRFDLDENKELRVYYHAHEEGVATINKYIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH5</accession>
    <name>A0A386PIH5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10940</name>
        <name evidence="3" type="ORF">EI377_05735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02522"/>
    <dbReference type="EnsemblBacteria" id="AYE34881">
        <property type="protein sequence ID" value="AYE34881"/>
        <property type="gene ID" value="CP523_10940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60276">
        <property type="protein sequence ID" value="QAS60276"/>
        <property type="gene ID" value="EI377_05735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="304" mass="35315" checksum="7CDFCAAE9348F612" modified="2018-12-05" version="1">MQYFIKAIGEFIMKNTVCAVIITYNCDENFLNTFNSVVNQVGKIVIVDNGSNKNTINMLKNIEKENDVQLILCEENLGIAAALNKGVKYALNNGYDWIITLDHDSNLKDDMVMKLLKGYNSLNDIEKEKVVSLLPRYIELGLNVDKQLNKEQEYIKYIEGGITSGNIVSRKAFEEVGLFDEKLFIDFVDYDFCFRIKEHGYDIVEVSDAILFHRIGETKEGRFFFKKVSATNHSPVRRYYITRNRIYCWKKYKNIVPESIKFDKSCALKETIKILLYEEKKFTKIKMIFKGIHDSNKGIFGKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH6</accession>
    <name>A0A386PIH6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11320</name>
        <name evidence="4" type="ORF">EI377_06140</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673245.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02821"/>
    <dbReference type="EnsemblBacteria" id="AYE34954">
        <property type="protein sequence ID" value="AYE34954"/>
        <property type="gene ID" value="CP523_11320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60349">
        <property type="protein sequence ID" value="QAS60349"/>
        <property type="gene ID" value="EI377_06140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362728" evidence="1">
        <location>
            <begin position="31"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="68"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="331" mass="36163" checksum="3E59DBDD4971F5A0" modified="2018-12-05" version="1">MIRKKARILSILLSATLLVGAFTGCNSTKNSEGANIEIQEEQFVLEYTDIMKEQGFTEAIVLEKKPERVVSISAASTALLFEVGASLVGIPKSTVFETPSDYTGEKLLSLMSDDFNIETVIALNPDLVIIPSSSKEQYGEALESSNIPVYYTNSGHSATYESVIQEAEVIIDAFAKDSEVGKEIMQRFKDLETKMEESKKVLAGKSVMILATTKYIQSKSGTVGSMAEMIGLTNVYENDNAGMVPLDQETTIGYTPDIILAIGSSPSVEDSKAILQEEFTTNSAYWGRFEAINNDKVVYLSSGYMPSTGIGVVKQISDLIDLIYEKLEINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK3</accession>
    <name>A0A386PIK3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11480</name>
        <name evidence="2" type="ORF">EI377_06295</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673306.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34984">
        <property type="protein sequence ID" value="AYE34984"/>
        <property type="gene ID" value="CP523_11480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60377">
        <property type="protein sequence ID" value="QAS60377"/>
        <property type="gene ID" value="EI377_06295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="7231" checksum="B1E10AFB08D06100" modified="2018-12-05" version="1">MFTKEELLVIEDALKIADEHYIKLLDASRNNKNQMVSYNRKQKKLWLVQNKLKKVIEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR3</accession>
    <name>A0A386PIR3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">secE</name>
        <name evidence="8" type="ORF">CP523_08900</name>
        <name evidence="9" type="ORF">EI377_03655</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678827.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01779"/>
    <dbReference type="EnsemblBacteria" id="AYE34526">
        <property type="protein sequence ID" value="AYE34526"/>
        <property type="gene ID" value="CP523_08900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59928">
        <property type="protein sequence ID" value="QAS59928"/>
        <property type="gene ID" value="EI377_03655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="77" mass="8711" checksum="6F0A06A4B7C64460" modified="2018-12-05" version="1">MAVKENVNLTKNPSEKGGISKFFREVKAEIKRITWPSKNDTKKALIAVGVVALIYIILVGGLDYIFQNLFELLFKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR5</accession>
    <name>A0A386PIR5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679074.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33999">
        <property type="protein sequence ID" value="AYE33999"/>
        <property type="gene ID" value="CP523_05715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="128" mass="14884" checksum="32FB606A87923592" modified="2018-12-05" version="1">MIIINTLDDIEKAEITPKELKEEILQHFQEIAESVVDKYWRMYNLKEVGDIVVLEDDDSIEVLSRYNLLDKKSKKITSIPEFTEVIVISDVEIIKTTFILGDSFGITLYHKIGKLGTENENFLKEYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS9</accession>
    <name>A0A386PIS9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_05830</name>
        <name evidence="11" type="ORF">EI377_00315</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675001.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01869"/>
    <dbReference type="EnsemblBacteria" id="AYE34019">
        <property type="protein sequence ID" value="AYE34019"/>
        <property type="gene ID" value="CP523_05830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59391">
        <property type="protein sequence ID" value="QAS59391"/>
        <property type="gene ID" value="EI377_00315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="160"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="220"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="443" mass="50930" checksum="E38C6D0A54D5F8C8" modified="2018-12-05" version="1">MKKITKKMIKCMFLINLVSILLGIILIWELLPLVYNNNEFKELEKVSKYVEEAIKNNENVVLDNTIVALLRDGQVINIGKNVDSQMKSDDFESLGGRKIYTTKSGNKYVTYKRSIAYGDLIVYKSYEVTEQLIKSVNVIMIGICCLSLIFSTLLAIYIGNRFTKPIIIIQNRAKDISKGIYTGNYQIDSNDEISDLSDSIEEMALELKAKDNIQRNFIANVSYDFKTPLSIIRANSQEIKNDSITGENLVECSDKIIHEVDMLNSLVEEILLLTKLKENNKFLKLKEQSLKIFLYESFRRILTSKSEYKCGFKNVKYKIDTRVEHLEKFNVKIDEKYLFMVISNIFNNALDYSECSEIALIVENTIYGIKVGIRDNGLGIKEENLKYIWDKYSTGDKNNGMRLGLAISKEIILAHEFNYGVKSKINKGTEFYFVIPHNLIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU8</accession>
    <name>A0A386PIU8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15735</name>
        <name evidence="3" type="ORF">EI377_10450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678904.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35770">
        <property type="protein sequence ID" value="AYE35770"/>
        <property type="gene ID" value="CP523_15735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61108">
        <property type="protein sequence ID" value="QAS61108"/>
        <property type="gene ID" value="EI377_10450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019250">
        <property type="entry name" value="DUF2227_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39085">
        <property type="entry name" value="PTHR39085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09988">
        <property type="entry name" value="DUF2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="186" mass="21517" checksum="9FDD5334EE515ECD" modified="2018-12-05" version="1">MAKGKTHDKVTLIVSPFIGLVFFMINSELLENSNKLVIVTLFGVVTYLFGGFMFSGDLDIKSSEYYRWGKIRFIWNPYQKIFKHRSIFTHGFLLGPIIRIIYTYIIVLIVCSVLYSLKVINLATDDLINLTLEYINSNKVISINIVLALFLGSGLHTITDLFSSFIKKKFRRKNKIYIKRKNKFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY7</accession>
    <name>A0A386PIY7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12495</name>
        <name evidence="10" type="ORF">EI377_07380</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675311.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02014"/>
    <dbReference type="EnsemblBacteria" id="AYE35174">
        <property type="protein sequence ID" value="AYE35174"/>
        <property type="gene ID" value="CP523_12495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60577">
        <property type="protein sequence ID" value="QAS60577"/>
        <property type="gene ID" value="EI377_07380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="8">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="320" mass="37192" checksum="88D0968FB939AE1F" modified="2018-12-05" version="1">MKYYLAPMEGITGYIYRNSYEKFFGNIDKYFTPFIVPNTSRSLKTKELRDILPENNKDMNIVPQILTNDSEGFIITSKKLQQLGYNEVNLNLGCPSGTVVSKNRGSGFLAKREELDIFLDEIFKIENMKISIKTRIGKDSPEEFYELIKIYNKYPIEELIIHPRTREDFYGNKPNLEVFKDALSLSKSPVCYNGDIFTVDDNNKLIEAFPEVKTIMLGRGILANPALVNEIKNNVYMDKKVLMDFHDEILSAYREVFNDDKNAMFRMKELWGYMIYIFSDNKKYAKKIKKAQKLSAYNEVVSSLFEEQEIIKGAGLFYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ15</accession>
    <name>A0A386PJ15_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Choline trimethylamine-lyase</fullName>
            <shortName evidence="2">Choline TMA-lyase</shortName>
            <ecNumber evidence="2">4.3.99.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Choline utilization protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">cutC</name>
        <name evidence="6" type="ORF">CP523_12430</name>
        <name evidence="7" type="ORF">EI377_07315</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>choline = acetaldehyde + trimethylamine</text>
            <dbReference type="Rhea" id="RHEA:35095"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="4.3.99.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine metabolism; choline degradation.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Requires the activating protein CutD to generate the key active site glycyl radical on Gly-821 that is involved in catalysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycyl radical enzyme (GRE) family. CutC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.4" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675336.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02027"/>
    <dbReference type="EnsemblBacteria" id="AYE35161">
        <property type="protein sequence ID" value="AYE35161"/>
        <property type="gene ID" value="CP523_12430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60564">
        <property type="protein sequence ID" value="QAS60564"/>
        <property type="gene ID" value="EI377_07315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12430"/>
    <dbReference type="UniPathway" id="UPA01069"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042426">
        <property type="term" value="P:choline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02058">
        <property type="entry name" value="Choline_CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030897">
        <property type="entry name" value="Choline_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010098">
        <property type="entry name" value="PFL2/GDeHydtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04394">
        <property type="entry name" value="choline_CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01774">
        <property type="entry name" value="PFL2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2 3" id="KW-0556">Organic radical</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="5">
        <location>
            <begin position="60"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="4">
        <location>
            <begin position="725"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine radical intermediate" evidence="2">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2 3">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="846" mass="95542" checksum="E0C063D240894FD0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ32</accession>
    <name>A0A386PJ32_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein subunit alpha/FixB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09570</name>
        <name evidence="7" type="ORF">EI377_04315</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676679.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02620"/>
    <dbReference type="EnsemblBacteria" id="AYE34652">
        <property type="protein sequence ID" value="AYE34652"/>
        <property type="gene ID" value="CP523_09570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60051">
        <property type="protein sequence ID" value="QAS60051"/>
        <property type="gene ID" value="EI377_04315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="5">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="335" mass="36034" checksum="417C86CD00F8A741" modified="2018-12-05" version="1">MNIADYRGVWVFAEQRGGELQKVSLELLGEGRKIADKLGVKLTALILGDKVKGLAETLGRHGADEVLVAEHELLKNYTTDGYTKVICDLASERKPGILFIGATFIGRDLGPRVAARLSTGLTADCTGLDVEVENGDLLATRPAFGGNLMATIACPDHRPQMATVRPGVFSKLGDEARDFKIEEVAVKLEEKDIRTKIVEIIKETKDIVDISEANFIIAGGRGVGSKENFKLLEGLAEVLGGTVAGSRAAVDNKWIDKDYQVGQTGKTVRPNIYIACGISGAIQHVAGMQESDMIIAINKDETAPIMKVADYAIVGDLNKVIPEMTAQLNAMKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE7</accession>
    <name>A0A386PJE7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_10150</name>
        <name evidence="8" type="ORF">EI377_04950</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676619.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00359"/>
    <dbReference type="EnsemblBacteria" id="AYE34736">
        <property type="protein sequence ID" value="AYE34736"/>
        <property type="gene ID" value="CP523_10150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60137">
        <property type="protein sequence ID" value="QAS60137"/>
        <property type="gene ID" value="EI377_04950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="271"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="393" mass="41731" checksum="C077D0A734F6C2EA" modified="2018-12-05" version="1">MREVVIVSAVRTPIGSFGGSLKDVSVADLGATVIKEAVARAGIKGEQVEEVLMGNVIQAGLGQNVTRQAAVRAGLPVEIPAMTINKVCGSGLRTVALAAQMIKAGDADVVVAGGIENMSSAPYLLRTARWGQRMGDGKMVDSMINDALWESFNNYHMGVTAENIAKQWNITREEQDEFALQSQLKAEKAIKEGRFKDEIVPVLIPQRRGEPKVFDTDEFPRFSSTIEGMKKLKPAFIKDGTVTAGNASGINDGAAAFVVMSADKAKELGVKPLAKIISYGQRGLDPSIMGYGPFHATKKALEVSGLKIEDLDLIEANEAFAAQSIAVARDLNFDMSKVNVNGGAIALGHPVGASGARILVTLLYEMQKRDAKKGLATLCIGGGMGTAMIVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJF7</accession>
    <name>A0A386PJF7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11890</name>
        <name evidence="3" type="ORF">EI377_06710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35058">
        <property type="protein sequence ID" value="AYE35058"/>
        <property type="gene ID" value="CP523_11890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60451">
        <property type="protein sequence ID" value="QAS60451"/>
        <property type="gene ID" value="EI377_06710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="79" mass="8529" checksum="F3D618307C91E339" modified="2018-12-05" version="1">MSKRRCEKKCECCCQDVCCNNGCGNVFNGLNSCCSPIIFLLIACGSGLLNNCRSYLIILLFLLCGGSFNSFFGGDNCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJT3</accession>
    <name>A0A386PJT3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11145</name>
        <name evidence="3" type="ORF">EI377_05935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677062.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00911"/>
    <dbReference type="EnsemblBacteria" id="AYE34922">
        <property type="protein sequence ID" value="AYE34922"/>
        <property type="gene ID" value="CP523_11145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60316">
        <property type="protein sequence ID" value="QAS60316"/>
        <property type="gene ID" value="EI377_05935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="28354" checksum="C560B997A01A3708" modified="2018-12-05" version="1">MLNLIRAELYKYSKRPFMYVYAGMLSLGILLIPILSNFWTVGIEYITREFIYTLIGSSFMGILIFSMLFGIVLQEEYKEKTLKNIIVSDISKTKIYIAKYISQVILGLILSAMCLIIFFIAISMVRTGDGYSSKLVGDFLIRFLVSIPMYMAGIALGDILVVLFKQSGMYALVYYFIIIFTPKVIDMLAWKVCDKIALVKSYLLTEALNKVIIPYPPIESMLKSLAISTMYIIVCLIIGIILINRREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU1</accession>
    <name>A0A386PJU1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10965</name>
        <name evidence="4" type="ORF">EI377_05760</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677659.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02527"/>
    <dbReference type="EnsemblBacteria" id="AYE34886">
        <property type="protein sequence ID" value="AYE34886"/>
        <property type="gene ID" value="CP523_10965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60281">
        <property type="protein sequence ID" value="QAS60281"/>
        <property type="gene ID" value="EI377_05760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="374" mass="43365" checksum="B780BE546C696BD1" modified="2018-12-05" version="1">MKVALIHDWLPFMGGAERVLSNFVEIYPDAPIYTTICNKEKLDSPIKEAKIFVSNIQKNKRNIENHRKYFPFMPTAMESFDLNKYNIVLSSSSSVAKGVITNPDTMHVCYCHSPMRYAWEFSYEYAGKMVGKSSLKNKLLNYFLTGMRLWDLATANRVDYFIANSENVAKRIWKHYKRESVVIHPPVRCKLFQISNVNEDYFLVVSRLQEYKKIDLAVEVFNELGLPLVIIGDGPERAKLEKMAKGNIKFLGRQPDEVIKEHYSKCRAFLFPGEEDFGITPLEAMASGRPVIAYGKGGALETVVEEKTGVFFKTQTSKDFKDAIKKFEKMEFNKKEIRAHAEKFDEEIFKRKIETFINESYEDFVNKKNWKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX8</accession>
    <name>A0A386PJX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13010</name>
        <name evidence="3" type="ORF">EI377_07885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677816.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35268">
        <property type="protein sequence ID" value="AYE35268"/>
        <property type="gene ID" value="CP523_13010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60663">
        <property type="protein sequence ID" value="QAS60663"/>
        <property type="gene ID" value="EI377_07885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="123" mass="13284" checksum="37F1CF642E86958F" modified="2018-12-05" version="1">MDKDQIKTLLRCAVFGFVWIAITTALGMLIVNLAGYNFKDVMFIQGIVLVILGLFASVSGNPMGLCIQALGNSNSQYVANTNLQIAKLDLKRRTNIKTTIIMSISTVALVMGGILSILVSFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK08</accession>
    <name>A0A386PK08_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">EamA/RhaT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10480</name>
        <name evidence="5" type="ORF">EI377_05255</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35857">
        <property type="protein sequence ID" value="AYE35857"/>
        <property type="gene ID" value="CP523_10480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62164">
        <property type="protein sequence ID" value="QAS62164"/>
        <property type="gene ID" value="EI377_05255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="130"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="283" mass="31164" checksum="956495F7DECC6FDE" modified="2018-12-05" version="1">MPIFAKLAYNNGSNSTTVLAVRFLLASLTLFIYFKIKRQNFKINKKQLYILCVLGVFGYTITSETLFMSYSYLSVGLATTVHFIYPAVVCLIGYLFFKERIGKMKLIALILSIIGVFILVGFENKTISILGVTLALISGVSYGANIIGLSLEDISSLDNKISTFYISIFSGVTMLILAILTKRLSLAINTEIFVSYIGISLVSTITSIIFLLKAIEEIGATSASILATFEPIVSIILGVLFFKESFTFPMLIGTMVILISVIIIAKSKEEKVIEKEEDTRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK27</accession>
    <name>A0A386PK27_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677503.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35328">
        <property type="protein sequence ID" value="AYE35328"/>
        <property type="gene ID" value="CP523_13325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="119" mass="14083" checksum="165EFC04A10E6CC2" modified="2018-12-05" version="1">MSNKLSVCHKRVKYTSYELVREVKKIVDKYNNVEECAKHYKVSEELIKNILKNSRILTFEMYKVISLMLNKSIKELTEIENVSLIPQFRGLKEEEQVEDLIEFANNIFEEIIINSKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK60</accession>
    <name>A0A386PK60_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Segregation and condensation protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">scpB</name>
        <name evidence="5" type="ORF">CP523_15170</name>
        <name evidence="6" type="ORF">EI377_10125</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ScpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678999.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00094"/>
    <dbReference type="EnsemblBacteria" id="AYE35664">
        <property type="protein sequence ID" value="AYE35664"/>
        <property type="gene ID" value="CP523_15170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61051">
        <property type="protein sequence ID" value="QAS61051"/>
        <property type="gene ID" value="EI377_10125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01804">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="203" mass="23057" checksum="162510C8F306C8B6" modified="2018-12-05" version="1">MNNIEINQCEFQGASKKARIKSSIEALLFVSGESLSLRTLSTHLEVSAKDLEKILEEMIVEYEEEHRGIKLISINGEYQLVTKAQNSDVIQKLLKKNKRQSLSQASLESLAIIAYKQPITRIDIDEIRGVKSESAIQRLIEKELIKEVGRLEVPGRPILFGTTEEFLRQFGLKTLKELPSIDLYGENEIEESIEVLNKAMKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKJ3</accession>
    <name>A0A386PKJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12505</name>
        <name evidence="2" type="ORF">EI377_07390</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675307.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35176">
        <property type="protein sequence ID" value="AYE35176"/>
        <property type="gene ID" value="CP523_12505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60579">
        <property type="protein sequence ID" value="QAS60579"/>
        <property type="gene ID" value="EI377_07390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032721">
        <property type="entry name" value="Toxin-deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14424">
        <property type="entry name" value="Toxin-deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="376" mass="44141" checksum="57DA95EEDBA82DAE" modified="2018-12-05" version="1">MTQGNMPLNRKKERLKINSIDEFKDALKREGYNINEIDEEKFKKKVTKTFYIDSNVTERLHRCINNSEITYRANDIRGFIDYIEKIILFEKEHNKLCEKISEINKLYIDRIEYQREVSSQDNVEDIIKAVEEIKSHVSSTITEEEKARLEALEKEIDEDYLYAKDIELLKKMILSRKETLKEKYNDKTKIKTISIEVPKQIDYQYIPAKRGSVEYHQHISNNIPRMQRLIKNMNKYMKSCGKEKTTFKINQSKALQDSINIAVAIFDNKEFKAISGSNNISNYCMAPPLEKAVFKSSKVNKLGKLGVGYNRVNDSEKKIFEEIHKQIEVKALKNEGNLILYSKWEPCPSCYSVISQFCKKYPDIKVKVKYSKKYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM6</accession>
    <name>A0A386PKM6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Anti-sigma factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_14355</name>
        <name evidence="11" type="ORF">EI377_09265</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02461"/>
    <dbReference type="EnsemblBacteria" id="AYE35518">
        <property type="protein sequence ID" value="AYE35518"/>
        <property type="gene ID" value="CP523_14355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60903">
        <property type="protein sequence ID" value="QAS60903"/>
        <property type="gene ID" value="EI377_09265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024449">
        <property type="entry name" value="Anti-sigma_RsgI_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12791">
        <property type="entry name" value="RsgI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51849">
        <property type="entry name" value="RSGI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RsgI N-terminal anti-sigma" evidence="9">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="298" mass="34386" checksum="C55A753F8AF29F7E" modified="2018-12-05" version="1">MDKKIRGIFMFKCLVMEIKDNIVIVMNDDGSMVRIRFKNGINVGDKIIYLKEDIINKKVKQFNYKPFMGIVALLMISILVYFNFKSISPYAEVSLDVNPSIKIELDENQNIIDIKGINKDGSSIDFTGIKGKNINDGILEIKQRLVEKNYILRGKSLLFGFAFVDTSENIQYEDRVKRVIKNTFNDNDVAFIKGDSNSISDSDKKGISLGRYSASLDFDDNKLEEIIENLTVDEILDAIKNKDKYIFWNAELQEEMMDELEDRFEEDKDSKDKADDDLEENEKQSNDDNKDDDLKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP7</accession>
    <name>A0A386PKP7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_14385</name>
        <name evidence="12" type="ORF">EI377_09350</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676850.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02468"/>
    <dbReference type="EnsemblBacteria" id="AYE35881">
        <property type="protein sequence ID" value="AYE35881"/>
        <property type="gene ID" value="CP523_14385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62194">
        <property type="protein sequence ID" value="QAS62194"/>
        <property type="gene ID" value="EI377_09350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="280"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS62194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="502" mass="57255" checksum="51F570BA6E3F7A53" modified="2018-12-05" version="1">MNKTISKKLFTITFGLILLVILSSVFFQVTFFEQYYLKHKTRDLANEVNKFKELYSFQIYSEETLKSALSRYEQENNSRIAIFSVNGELSYLSDYRKGVDDLRTLTQFCAELINNKELIYDVISTGETKQTIFENESSGSKKIGIVSPMSLKYKNDSIIISVSSIQPIQEAGLVIKDFYKYLVVGFSIIGIILSSIYVNLITKPLVKINKVAKKMSSMDFSVKCEVNSEDEIGNLAKTLNFLSSNLNNALEDLKQKNKQLEKDIEKERKLETLRKDFVAGVSHELKTPIGIIEGYAEGLKDGIVEGENAIVYLDTIIDESKKMSKLVSNMLELSKLESETIELHLEDFNIIRLIKKVTKSLSLEFQSKSIDVIFENTLPYAYVTGDIFQLEQVFTNLLTNAFKYSPANEKVIISLNKNDNKYIISIENTGSHIPEDELENIYAKFYRLDKARTRTDNSNGLGLAIVKRILINHKSKYLIENTLSGVKFTFSLNESKEELEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP8</accession>
    <name>A0A386PKP8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_12830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35236">
        <property type="protein sequence ID" value="AYE35236"/>
        <property type="gene ID" value="CP523_12830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="412" mass="47659" checksum="9C6BC67BD9F96009" modified="2018-12-05" version="1">MTRKIDTNFDYNEEIKRCKTIDDVMGKNGLIQRLVKDVLENILEGEMEEHLGRNKYERVEAVDQTKKNYRNGYSRKNLRSSFGDVDLDVPRDRNAEFEPQIIKKYETVCTELYKKIISLYAKGMSTSDIQAEIEDLYGITISPSMVSKITDKVLASAAEWQNRALDKIYPIVYLDAMYFKVRSNGKIVNKAVYICLGYTMEGYKDILGIWVDEAEGAKFWLGICNDLKNRGVKEILIACMDGLKGLPQAIKTVFPSVNIQTCIVHQIRNSIKYIASKDKKAFMKDLKEVYKATTEELALAQLDNLKERWGDKYGIVIDSWYNNWSNLSTFFDFSPTIRKMIYTTNILEGFNRQIRKFTKVRVIFPTDESLNKCVYLATMEILEKWTQPIHNWGATLAELSIIFEDQLKDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKU5</accession>
    <name>A0A386PKU5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA-disulfide reductase</fullName>
            <ecNumber evidence="5">1.8.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11130</name>
        <name evidence="5" type="ORF">EI377_05920</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677066.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00914"/>
    <dbReference type="EnsemblBacteria" id="AYE34919">
        <property type="protein sequence ID" value="AYE34919"/>
        <property type="gene ID" value="CP523_11130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60313">
        <property type="protein sequence ID" value="QAS60313"/>
        <property type="gene ID" value="EI377_05920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050451">
        <property type="term" value="F:CoA-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032836">
        <property type="entry name" value="DsrE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13686">
        <property type="entry name" value="DrsE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="464"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="816" mass="89800" checksum="3120AE9E80112D02" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKY0</accession>
    <name>A0A386PKY0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1292 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13475</name>
        <name evidence="3" type="ORF">EI377_08375</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00792"/>
    <dbReference type="EnsemblBacteria" id="AYE35356">
        <property type="protein sequence ID" value="AYE35356"/>
        <property type="gene ID" value="CP523_13475"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60747"/>
        <property type="gene ID" value="EI377_08375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="90" mass="10703" checksum="C137B84350B25CA4" modified="2018-12-05" version="1">MEKNSVNIKEDEREVMTFLDEEGNKVEFEGVARIYIKEKEYLLLASLEDSNSEDVYVFRVDEKDGKQELNLVEDDKEFLAVKKEYKKLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL14</accession>
    <name>A0A386PL14_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11655</name>
        <name evidence="3" type="ORF">EI377_06475</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02890"/>
    <dbReference type="EnsemblBacteria" id="AYE35019">
        <property type="protein sequence ID" value="AYE35019"/>
        <property type="gene ID" value="CP523_11655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60413">
        <property type="protein sequence ID" value="QAS60413"/>
        <property type="gene ID" value="EI377_06475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="420" mass="49616" checksum="9DA77BDD5BA4446F" modified="2018-12-05" version="1">MEILSTGEKIKRSRVYQGITLKELCGDKISISKMSCIENGKIKADTGILSYIAKKLGVDYNYLVQDVHEQIMANLELLRKNSVSDDEIDELIQHNLSYAIEYSYDDLAFELIHRLFNFYVENKKVENIQLIVSQYYDLYQKNNTIANTITYYRDMAMFFYSIEEYNEAINYYNKIREIIIEKDIEDKAVYAYISYREGLCYEKLGNIENSYNCLKEAVLNIDSIEDHMDKGDIYHSFATLNIMLNKKEADSYIEKAYEYQKDNPMALAISKGKNGKCYFYINNREKAIAEIKEGIEIFPKHNVKKYVKFLSDCIKVLYDNKEYNLAYELTDTTLNLAINTEDIVLIEEAYYLKGMTLQKLERYKEAEVYMNLSLDSLFKFANKEKRYKRYLDMAEMYYNLNEPKDALKYFTLAIKMEENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL30</accession>
    <name>A0A386PL30_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14485</name>
        <name evidence="8" type="ORF">EI377_09460</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676840.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02490"/>
    <dbReference type="EnsemblBacteria" id="AYE35542">
        <property type="protein sequence ID" value="AYE35542"/>
        <property type="gene ID" value="CP523_14485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60928">
        <property type="protein sequence ID" value="QAS60928"/>
        <property type="gene ID" value="EI377_09460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="106"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="314" mass="34467" checksum="4D43EEBA7C43D5C4" modified="2018-12-05" version="1">MENNFEMDKALFTPLSEDEKNFEQVVRPSVGYWKDAWTRLKRNKVALVSLIVIVLIILAAIVVPSMSKFAYDATDLGKTNMKPDSIHWFGTDALGRDLFVRVMYGARYSLIIAFAATVINLVIGVIYGGVAGFVGGRVDNLMMRIVDVLYSIPTLIYVVLIMAAFYDPTSGKSGISTIILALSISYWVGMARIVRGDILQLKQQEFVLAARTLGASKFRILFKHLIPNCIGSIIVTMTLLVPQAVFTEAFLSFIGLGINPPLASLGTLANDAMGAIYVHPYQLIFPAAAICLIILSFNLLGDGLTEALDPKHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL46</accession>
    <name>A0A386PL46_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11945</name>
        <name evidence="9" type="ORF">EI377_06765</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673458.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02947"/>
    <dbReference type="EnsemblBacteria" id="AYE35069">
        <property type="protein sequence ID" value="AYE35069"/>
        <property type="gene ID" value="CP523_11945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60462">
        <property type="protein sequence ID" value="QAS60462"/>
        <property type="gene ID" value="EI377_06765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
        <property type="entry name" value="MATE_SpoVB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024923">
        <property type="entry name" value="PG_synth_SpoVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038958">
        <property type="entry name" value="PG_synth_SpoVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="361"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="539" mass="59397" checksum="911CD6CF984B283A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL75</accession>
    <name>A0A386PL75_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta-lactam-biosynthetic de-N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdaA</name>
        <name evidence="3" type="ORF">CP523_14830</name>
        <name evidence="4" type="ORF">EI377_09790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01317"/>
    <dbReference type="EnsemblBacteria" id="AYE35602">
        <property type="protein sequence ID" value="AYE35602"/>
        <property type="gene ID" value="CP523_14830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60989">
        <property type="protein sequence ID" value="QAS60989"/>
        <property type="gene ID" value="EI377_09790"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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    </dbReference>
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        <property type="entry name" value="CE4_BsPdaA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
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        <property type="entry name" value="NODB_dom"/>
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        <property type="entry name" value="Spore_PdaA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363003" evidence="1">
        <location>
            <begin position="28"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="72"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="30050" checksum="C84176440D113D37" modified="2018-12-05" version="1">MKKLKIIIPLFLVALLIFMPSFTVANALISDDAELNWYFVNRNDGKTPECPKESADFFEDLDAYYVGDTNKKVLYLTFDEGYENGNTPKILDILKEEKVPAAFFVVKPYIKDCPDIVKRMEEEGHLVCNHTSHHPSMAKITDAEKFKKEFTDVEDEFKELTGKDMPKFFRPPMGKYSKNSLKKTKDLGYKTIFWSFAYKDWLVDNQPSEDAAIKKITSGAHNGSIMLLHAVSDTNVKVLKTVIEQLKSEGYEFKPLTELPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL92</accession>
    <name>A0A386PL92_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="5">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="5">UPRTase</shortName>
                <ecNumber evidence="5">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">pyrR</name>
        <name evidence="7" type="ORF">CP523_14935</name>
        <name evidence="8" type="ORF">EI377_09890</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer and homohexamer; in equilibrium.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676066.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01297"/>
    <dbReference type="EnsemblBacteria" id="AYE35622">
        <property type="protein sequence ID" value="AYE35622"/>
        <property type="gene ID" value="CP523_14935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61008">
        <property type="protein sequence ID" value="QAS61008"/>
        <property type="gene ID" value="EI377_09890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 5" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="5">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="179" mass="20104" checksum="6A1A24FB1E44A063" modified="2018-12-05" version="1">MNLKANLLDDKAIKRSLIRISHEIIERNKGVEDVVLVGIKRRGYPLAKRIAKNIENIEGVNIPVGYVDITLYRDDVTEIKDMPKVKNKDIGGIQVKGKKVILIDDVLYTCRTVRAAIDAIIDEGRPNQIQLAVLIDRGHKELPIRADFVGKNIPTSKNEIIAVEIEEIDGVDSVKIYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLA8</accession>
    <name>A0A386PLA8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein AG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIIAG</name>
        <name evidence="3" type="ORF">CP523_15040</name>
        <name evidence="4" type="ORF">EI377_09995</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676027.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01276"/>
    <dbReference type="EnsemblBacteria" id="AYE35642">
        <property type="protein sequence ID" value="AYE35642"/>
        <property type="gene ID" value="CP523_15040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61029">
        <property type="protein sequence ID" value="QAS61029"/>
        <property type="gene ID" value="EI377_09995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014195">
        <property type="entry name" value="Spore_III_AG"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02830">
        <property type="entry name" value="spore_III_AG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="202" mass="22219" checksum="ECF9CA49591D55A0" modified="2018-12-05" version="1">MGKDNFKKELTSILSNPKFLNIVSIALVIAFVLLAISFLSTNRKKEAKATDGPSISEANNKDTSNTPKEILDYEEVQKKELKEILTKMDGVGVVDVMMYFESSEVKVPAINENTQVSKTEESDKDGGKRVNTQKNDGSQVVMSGNGSENEPFILKTYKPKITGIVIVAEGADNSKIKYDIQTAISSLYGISLDKVNVYPMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLB6</accession>
    <name>A0A386PLB6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_08120</name>
        <name evidence="9" type="ORF">EI377_02875</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675998.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00738"/>
    <dbReference type="EnsemblBacteria" id="AYE35848">
        <property type="protein sequence ID" value="AYE35848"/>
        <property type="gene ID" value="CP523_08120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62155">
        <property type="protein sequence ID" value="QAS62155"/>
        <property type="gene ID" value="EI377_02875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041365">
        <property type="entry name" value="CspB_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18425">
        <property type="entry name" value="CspB_prodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="CspB_prodomain" evidence="7">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="125"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="434"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="697"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1201" mass="131573" checksum="8B025CF367661D1D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLF8</accession>
    <name>A0A386PLF8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrothymine dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">preA</name>
        <name evidence="10" type="ORF">CP523_14795</name>
        <name evidence="11" type="ORF">EI377_09755</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676112.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01324"/>
    <dbReference type="EnsemblBacteria" id="AYE35596">
        <property type="protein sequence ID" value="AYE35596"/>
        <property type="gene ID" value="CP523_14795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60982">
        <property type="protein sequence ID" value="QAS60982"/>
        <property type="gene ID" value="EI377_09755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044512">
        <property type="entry name" value="DPYD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="PTHR43073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="411" mass="45576" checksum="B96924AC286CCC39" modified="2018-12-05" version="1">MKKKDLSIEFCGVKCENPFFLSSSPVGNCYEMCAKAFETGWGGVVFKTIGFFKPNEVSPRFTNLRKESTSFIGFKNMEQIAEHSLEENLDALRKLKENYPTKVVVASIMGQNEKEWEELAKLVTEAGSDIIECNFSCPQMTSHDMGSDVGQNPELVKSYCKAVRRGTNLPILAKMTPNIGDMTVPAIASIEGGADGLATINTIKSITQIDFDKMTALPIINGKSSVSGYSGKAVKPIALRFIYELRKNEKLKNIPISGIGGIETWEDALEFILLGSSNLQVTTAVMQYGYRIVEDMISGLSHFMDEKGFDKLEDMVGLAVKNVIPAEDLDRGYIIYPKFNEETCVGCGRCYISCYDGGHQAIKWNNENRKPMLNKDKCVGCHLCANVCPTESISKGEIEFKNGEKEKKIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM98</accession>
    <name>A0A386PM98_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">khpA</name>
        <name evidence="3" type="ORF">CP523_00800</name>
        <name evidence="4" type="ORF">EI377_11295</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674656.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02360"/>
    <dbReference type="EnsemblBacteria" id="AYE35789">
        <property type="protein sequence ID" value="AYE35789"/>
        <property type="gene ID" value="CP523_00800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61262">
        <property type="protein sequence ID" value="QAS61262"/>
        <property type="gene ID" value="EI377_11295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="79" mass="8628" checksum="9F7FE5E46E76F592" modified="2018-12-05" version="1">MKELIEVIAKSLVDNPNEVHVNEIQGEQSIILELKVAPVDMGKVIGKQGRIAKAIRTVVKAAAIKEDKKVVVEIIDVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB15</accession>
    <name>A0A386PB15_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00865</name>
        <name evidence="8" type="ORF">EI377_11360</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674569.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02346"/>
    <dbReference type="EnsemblBacteria" id="AYE33105">
        <property type="protein sequence ID" value="AYE33105"/>
        <property type="gene ID" value="CP523_00865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61275">
        <property type="protein sequence ID" value="QAS61275"/>
        <property type="gene ID" value="EI377_11360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="6">
        <location>
            <begin position="3"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="331" mass="35966" checksum="1B2702AB10AA4E87" modified="2018-12-05" version="1">MELMEKLWDAAKDDKKRIVLPEGDEERTIVAAEKIEELGLAYPVLIGDEEKINAKASELGVNLEGVEIINPNKSDRLEDYVKAFYELRKNKGMTMEKAEMIVKDPLYFGTMMVKLDDADGMVSGAVHTTGDLLRPGLQIIKTAKGVSVVSSFFIMMVPGSEYGEGGMLLFSDCAVNPNPNAEQLAAIAIATADTARNLCKIEPRVAMLSFSTMGSADHEMVDKVRKATEIAKELRPDLLIDGELQLDAAIVEKVARQKAPNSKVAGKANVLVFPDLQSGNIGYKLVQRFANAEAIGPMCQGFDKPINDLSRGCSSDDIVNVVALTAVQSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBQ7</accession>
    <name>A0A386PBQ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02285</name>
        <name evidence="6" type="ORF">EI377_12805</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674012.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00510"/>
    <dbReference type="EnsemblBacteria" id="AYE33373">
        <property type="protein sequence ID" value="AYE33373"/>
        <property type="gene ID" value="CP523_02285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61543">
        <property type="protein sequence ID" value="QAS61543"/>
        <property type="gene ID" value="EI377_12805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="377" mass="43996" checksum="A88F68ACE423576C" modified="2018-12-05" version="1">MKEIALYIHIPFCKQKCLYCDFPSYASLENLMDDYVDALCMEIQEKAKEYLISSIFIGGGTPSYLNKNQIEKLLNSINKLNKTKNMEFSMECNPGSLDEEKLKTMFLGGVNRISIGLQAVQDSLLKSIGRIHTYREFVENFNLARKIGFKNINVDLMFGLPNQKISHWKESLETIANIKPEHISSYSLIIEEGTCFYNMWNKDKLNLPSEEDEREMYSMTKEILKSHGYKQYEISNYSKEGYECLHNKVYWQCKPYLGVGTSASSFLDEYRFKNIDKVKEYIKRINNNESVVEEKLKNSIEDDIEEFMFMGLRLIEGVCKREFELRFGRNIRSIYNEIIDKNISMGLLEEDNNILRLTSKGVELSNVVMSDFIIDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC13</accession>
    <name>A0A386PC13_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_00720</name>
        <name evidence="15" type="ORF">EI377_11215</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674648.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02376"/>
    <dbReference type="EnsemblBacteria" id="AYE33077">
        <property type="protein sequence ID" value="AYE33077"/>
        <property type="gene ID" value="CP523_00720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61246">
        <property type="protein sequence ID" value="QAS61246"/>
        <property type="gene ID" value="EI377_11215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00720"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="29488" checksum="D064398422362B73" modified="2018-12-05" version="1">MKSNNRYLGALMIAPFIIFIFLGGIYLKAFTIVLSICGLYEFFNALKQKEFRPIPLISYIMLALFYLTGNNFNILIFILIFSSFILLCFPVIDLKYTFIDVALTILGFIYVGILFSFIPLVNSKISGEYLVWIIFLGSWLADTAAYYSGKYFGKKKLCPKVSPKKTIAGSIGGFLGSTFGCGIFGIIVGKFTPEVQIIHFFLMGALCGIMGQFGDLVASSIKRYVGIKDYSNLIPGHGGILDRFDSILFNATVVFYYLTFIVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCD9</accession>
    <name>A0A386PCD9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33440">
        <property type="protein sequence ID" value="AYE33440"/>
        <property type="gene ID" value="CP523_02655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="301"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="387" mass="42123" checksum="948E0D9FCB4B6D48" modified="2018-12-05" version="1">MIINHNMNAMNAHRNMASNTVATGKSMEKLSSGLRINRAGDDAAGLSISEKMRGQIRGLEQASRNSQDGISLIQTTEGALNETHSILQRMRELSVQASNDTNTAEDRGQLTKELDQLRSEIDRISSQTQFNKMDVLNGDGDKSFKANIQVGANSNQAIEIAIEKMDYSSLFKAHKVASTDEVKGDITVKTGKDIKVTIDTKEITIKADAKVDKTLTKEELVAEINKGIEAEATLKGKVSASFADNKLTISRIDGEDKEVTVKVEDNNASGNTKLGLDGDNKSKMEVFNVDLTSHAAATGSISAIDRAIEKVSTQRSQLGAYQNRLEHTIKNVDNAAENLQAAESRVRDVDMANEMMTFSKNNILTQAAQAMLAQANQQPQGVLQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCH8</accession>
    <name>A0A386PCH8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Exonuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00445</name>
        <name evidence="3" type="ORF">EI377_10935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676292.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00617"/>
    <dbReference type="EnsemblBacteria" id="AYE33024">
        <property type="protein sequence ID" value="AYE33024"/>
        <property type="gene ID" value="CP523_00445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61193">
        <property type="protein sequence ID" value="QAS61193"/>
        <property type="gene ID" value="EI377_10935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="248" mass="29270" checksum="C52C78F05B769AEA" modified="2018-12-05" version="1">MSYIVFDLEFNQCYDPTDENKIITNSLCPFEIIQIGAIKLDEYLNNINYFDRLIKPTVYPYIHPFVRELTGIKDEDLIKSDDFSIIIKNFFEFAKSKDSIFIVWGTTDIKEIVRNMKFHKINIDSLEIRYIDLQKIISKKLKCPKGIKIGLSKALEIYNIELDKDLHNAFNDAYYTAEVFKKVYNSNIKPSIYNFKIYNSKSTSNKLNIDYDKLFSQFEKMYSKSLTTTEKEMIKLAYIMGKTNQFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCS7</accession>
    <name>A0A386PCS7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03465</name>
        <name evidence="2" type="ORF">EI377_13990</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02244"/>
    <dbReference type="EnsemblBacteria" id="AYE33590">
        <property type="protein sequence ID" value="AYE33590"/>
        <property type="gene ID" value="CP523_03465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61754">
        <property type="protein sequence ID" value="QAS61754"/>
        <property type="gene ID" value="EI377_13990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="293" mass="34578" checksum="5F6A41B58328F6CE" modified="2018-12-05" version="1">MFGYVTPLIDELKVRDFNLFKYYYCGLCLHIKERFGNIPRMTLNYDMTFLGVLLDSLSKDEPNFKIIKCISHPTQKRSIVINNHALSYAADINVSLFYYKLLDDIKDDNKFKSKLYATSLYLYTKKFDKSMSAINELIKNRLSQLSTFEKEKSFSSIDEISDPFSDIVGNILKNYPYSLFKDGKNLRDDLYNFGYSLGKWIYIIDALDDLKEDIKKNKFNPINQLYNKENLPFEKLHTILKPKIEFIILNCSYNCREYLKKLPIKRNKDILYNIIELGMIKKYITIVNNYGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCT6</accession>
    <name>A0A386PCT6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04485</name>
        <name evidence="2" type="ORF">EI377_15025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676415.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33783">
        <property type="protein sequence ID" value="AYE33783"/>
        <property type="gene ID" value="CP523_04485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61940">
        <property type="protein sequence ID" value="QAS61940"/>
        <property type="gene ID" value="EI377_15025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="30394" checksum="CEAED4F7294F37E4" modified="2018-12-05" version="1">MYYNKIYDFIKKLDSTNIEEYKPQLTKYIIELMLSFKDYNNSISLEDLQFMLDTALLREEFQCELKNELEEEGFKLGLLTGAFIDIYKEFTSNIAENGYINDAISLTRSVIKALDCISIPFYLIKKNGGFNEENLKYMESIDYLNDLQEELGKYLNQYVTNTSKEYFNVLGLVEYIKKELEENINNIGHIIMSQLSNKSLEDFNKEEHMNEYKAIFKKEYIEELKRRKYQWSILTSKLKENYFRDELYKDLDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCV8</accession>
    <name>A0A386PCV8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ppx/GppA family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01995</name>
        <name evidence="3" type="ORF">EI377_12515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678252.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01149"/>
    <dbReference type="EnsemblBacteria" id="AYE33317">
        <property type="protein sequence ID" value="AYE33317"/>
        <property type="gene ID" value="CP523_01995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61487">
        <property type="protein sequence ID" value="QAS61487"/>
        <property type="gene ID" value="EI377_12515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="502" mass="56773" checksum="9EB88E27A2B0872A" modified="2018-12-05" version="1">MNRVGVIDIGPSSVRLMLTEVEEGGYFKIIDELKTSIRLCDDLVNDCSICKDKINSIISTLRSYKSLCTISGVTKIFAVATESFRTADNKDLLISLIKKELDIEVNVLSCKDEIYLNYLGVTKSIYVENSLMVEVAGTATHIAWIKDHKIIRSSTLPFGSVNLTFKHNLNDRVLPNSIDNALNIIKSSLNAIEWFKEAKFDSVIGVAEIVRNLGKIDRVRKRYPFDIPHNYELTDIDVQEIFNIVKSKDFKQRQKIEGLDFELADIIVGGTAIFCSIVKIANASNVIISGRGLREGIMYDYLEKTYNLDNDILDYSINGILDTLNINKCHAKHVFDITSKLFDSLRPLHNLGEKYYHIVKTASMLHDCGISINYYDHHKHSFYVILHSYINGLSHKELLMSAAIAASHRFNSYKLPLPPFATIINQLDLKCIAQIGVLLKISEGLDRSLVGAIKDINVEFDSNEVKLTVWSDIDVELEIRQALRASSRFKEVYNRDLIIIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD29</accession>
    <name>A0A386PD29_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="8">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ddl</name>
        <name evidence="12" type="ORF">CP523_04045</name>
        <name evidence="13" type="ORF">EI377_14565</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676917.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02777"/>
    <dbReference type="EnsemblBacteria" id="AYE33700">
        <property type="protein sequence ID" value="AYE33700"/>
        <property type="gene ID" value="CP523_04045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61855">
        <property type="protein sequence ID" value="QAS61855"/>
        <property type="gene ID" value="EI377_14565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04045"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="99"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="301" mass="34054" checksum="A9C7F26C926021CA" modified="2018-12-05" version="1">MKIGVIMGGISSEREVSLNSGNSIVENIDKNKYEVVPIIIDKKEDIINKVKGIDFALLALHGKFGEDGTVQSVLQTLDIPYSGCGPLSSALCMDKDLTKRILKSNNIRTARWLNVRSVEEIDYDKIEEMKYPVFIKPTNGGSSVATFKITKKEDVEEAVREGLKWDNEVMIEEFIKGEEITCPVFKGEMFPVIAIRPKTDFFDYTQKYSGDGAEEVIIELEEKLHKEVEQMALDTYKALKCSVYSRIDMIVTEDRTPYILEVNTLPGMTKTSLFPKSAEAKGINFTKFIDMIIEHSIKENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD64</accession>
    <name>A0A386PD64_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class B sortase</fullName>
            <ecNumber evidence="4">3.4.22.71</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SrtB family sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">srtB</name>
        <name evidence="3" type="ORF">CP523_05300</name>
        <name evidence="4" type="ORF">EI377_15860</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.22.71" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676276.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33933">
        <property type="protein sequence ID" value="AYE33933"/>
        <property type="gene ID" value="CP523_05300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62084">
        <property type="protein sequence ID" value="QAS62084"/>
        <property type="gene ID" value="EI377_15860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="32083" checksum="1DB087308C139038" modified="2018-12-05" version="1">MFLDLREKMNLKNKGYNKILKRKLSLLEYIRFFMFFICLVTFVISSFIIIKRLVEYRENKKVYNEMRVYSPEVMKDNESNKRGFLEEDFKKLKDINSDIKAWITIPNTEVNYPITQGINNEYYLNHNFKKEKNNGGSILIEYDNKTPFNKGNTVIHGHNMKDGSMFADLLKFKEENFFNNNNKIYITLENEVIEYEIFSIYVEELDKEHYNNQFYYNGDYIRYLNDLKSKSIFNSNVELKSDKDIITLSTCDFSIHDGRLIIHAIRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD91</accession>
    <name>A0A386PD91_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF5011 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_01860</name>
        <name evidence="10" type="ORF">EI377_12380</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677281.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02379"/>
    <dbReference type="EnsemblBacteria" id="AYE33294">
        <property type="protein sequence ID" value="AYE33294"/>
        <property type="gene ID" value="CP523_01860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61465">
        <property type="protein sequence ID" value="QAS61465"/>
        <property type="gene ID" value="EI377_12380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011081">
        <property type="entry name" value="Big_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032179">
        <property type="entry name" value="Cry22Aa_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035364">
        <property type="entry name" value="Glyco_hyd_101_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07532">
        <property type="entry name" value="Big_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16403">
        <property type="entry name" value="DUF5011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17451">
        <property type="entry name" value="Glyco_hyd_101C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033787955" evidence="6">
        <location>
            <begin position="41"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1686"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="8">
        <location>
            <begin position="1678"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1660"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1665"/>
            <end position="1680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1708" mass="190463" checksum="1ADAFB80F58DADCA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDB8</accession>
    <name>A0A386PDB8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4237 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05630</name>
        <name evidence="3" type="ORF">EI377_00060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33985">
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        <property type="gene ID" value="CP523_05630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59348">
        <property type="protein sequence ID" value="QAS59348"/>
        <property type="gene ID" value="EI377_00060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061810">
        <property type="term" value="F:NAD glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
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        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="1">
        <location>
            <begin position="93"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="20233" checksum="BBF0D16C81508902" modified="2018-12-05" version="1">MGYLPEIANKIKNGERVERIVDSIRGSKGVSEADKLKLSSWKYAPDEELYLKYKDVFDNPKYYNQTTGEINWPGQHGDKNIDGFLNGKFYEVTLKPGEKIDRYGTDYGSFASPEGISYGQRALAPGTDLKPYSVFEVIKPMKVKAGEIAPWFNETGGGIQYVLPDIIDELLDAGIIRRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDD0</accession>
    <name>A0A386PDD0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02085</name>
        <name evidence="2" type="ORF">EI377_12605</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33334">
        <property type="protein sequence ID" value="AYE33334"/>
        <property type="gene ID" value="CP523_02085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61504">
        <property type="protein sequence ID" value="QAS61504"/>
        <property type="gene ID" value="EI377_12605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="30564" checksum="9DB826941BD8752C" modified="2018-12-05" version="1">MIKLIATDLDGTLLDENSNVPHEFSDVLKEITDRNIKFVAASGRPYYTLKEDFGKLANHVTFVSDNGAMIVENDEMIHCNIIEKTLVKEVINIYKKLKNAHIVLCGKECAYIEDTDPRFVEEVDNFYYKKEIVDNIENVDDDIVKITFCDFNDVEKLSEKYFAKELENKLQVVVSGKIWLDIMDNKTNKGVGLKKIQDKYAITSGETMVFGDYYNDIPMFEKAFFTYAMDNSPEEVKLKAKYTIESNSDYGVIKVLKDKYLKNKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDJ7</accession>
    <name>A0A386PDJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06105</name>
        <name evidence="4" type="ORF">EI377_00580</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675122.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01921"/>
    <dbReference type="EnsemblBacteria" id="AYE34073">
        <property type="protein sequence ID" value="AYE34073"/>
        <property type="gene ID" value="CP523_06105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59443">
        <property type="protein sequence ID" value="QAS59443"/>
        <property type="gene ID" value="EI377_00580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18925" checksum="264F80F78672E3CA" modified="2018-12-05" version="1">MRFKFCPLCGRELEEKYSFDEGGVPYCKYDDIMFFDTPKPCIMVAVIKNDEILLLKQSYIFKNSKVLLSGYVSHNETVEETVYREVKEESGLDISNIQYLGSDFVKDKEILMLTFMAKYESGDIIKSTEVEAMAWCKLETALDEMKEDKIGSKVVSKVLNNINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDV0</accession>
    <name>A0A386PDV0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33970">
        <property type="protein sequence ID" value="AYE33970"/>
        <property type="gene ID" value="CP523_05535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="92" mass="10541" checksum="0254AAEE5F0DE8F4" modified="2018-12-05" version="1">MWIEQGSAYDVAASQCMYYDQPQNELDEIVILITIATRFARCGKPLGDDFKQVLKKKIESFNILDLSKYNLNEDELKALKEEISEVSGYISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE31</accession>
    <name>A0A386PE31_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07385</name>
        <name evidence="2" type="ORF">EI377_02075</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673774.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01086"/>
    <dbReference type="EnsemblBacteria" id="AYE34285">
        <property type="protein sequence ID" value="AYE34285"/>
        <property type="gene ID" value="CP523_07385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59679">
        <property type="protein sequence ID" value="QAS59679"/>
        <property type="gene ID" value="EI377_02075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="19288" checksum="80F1D8855EAD09F5" modified="2018-12-05" version="1">MSLYKQWTDMVVEYVKTKGEQAFWAEYTQIETSIYKDLLANHNKQENTTIEDLAKKYGTTAEFVMGFVDGINDSLNTTYDLETLKVNDKILLDINLEKLYFNMLDAKAEYLYNLPQWDAIFSKEKRKEIQKQYRDSVIVRNENKIGRNDPCTCGSGKKYKKCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE50</accession>
    <name>A0A386PE50_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">YitT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_06140</name>
        <name evidence="10" type="ORF">EI377_00620</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34080">
        <property type="protein sequence ID" value="AYE34080"/>
        <property type="gene ID" value="CP523_06140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59450">
        <property type="protein sequence ID" value="QAS59450"/>
        <property type="gene ID" value="EI377_00620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="287" mass="31301" checksum="9D825867A26AF0F4" modified="2018-12-05" version="1">MNKERFLKELKDYGIITFGVILVAIALVYFYAPNNLAAGGLSGIALIINHFVPTMSIGGMLFVGNAVLYIIAFLVIGPEFGIKTIYASFGLSAIIWFMEKFGNPHPITEDLMLASIFGTILVAIGMAIVFNANASTGGTDIIAKILNKYTTFNIGISLLMVDFLVTLVAGLTFGSDTGFYALLCVLVNGPMIDKLIAMFNAKKQITIVSDKNDEISNYIMNTLKRGCTRLRGAGAFTGEDRDIIYTVLEKKDLATLKEFIDTVDNEAFITIGHIEEVKGKGFPQLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE53</accession>
    <name>A0A386PE53_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01960</name>
        <name evidence="4" type="ORF">EI377_12480</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678261.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01156"/>
    <dbReference type="EnsemblBacteria" id="AYE33311">
        <property type="protein sequence ID" value="AYE33311"/>
        <property type="gene ID" value="CP523_01960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61481">
        <property type="protein sequence ID" value="QAS61481"/>
        <property type="gene ID" value="EI377_12480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362697" evidence="1">
        <location>
            <begin position="36"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="50"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="32403" checksum="6643ADD959B16227" modified="2018-12-05" version="1">MEVFYLKKKLSILSLFLLVFCFVFVGCNINSPSNTDNTKDMKVHYIDVGQGDSILIQVNNKNMLIDCGPRDGKDKLFSYLESQKITKLDYVVATHPHEDHIGNMADVIKKYDVDKFYAPKVEHTTKTFEKMIEALASKNLKITTIKAGTKSIDLGENTKVSVVAPNSATYDDLNDYSPIIKVEYGKNSFLFTGDAEKKSEKEVLSKNYNIEADVLKLGHHGSSTSTSKEFFNAVNPSIAVITLASDNKYGHPHKETINLLKEKKTTVYRTDTDGNIVLSSDGNKISKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA1</accession>
    <name>A0A386PEA1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_00230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677379.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01186"/>
    <dbReference type="EnsemblBacteria" id="AYE32986">
        <property type="protein sequence ID" value="AYE32986"/>
        <property type="gene ID" value="CP523_00230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00230"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="159"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="368"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE32986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="488" mass="55437" checksum="415EE272099B1969" modified="2018-12-05" version="1">MNRLNLSETRNMTMLMDFYELTMSNGYLNNNLGNKIVYFDVFFRKVPEKGGFAIMAGLDQVIEYIKGLRFNEKDISYLRSLDIFKEEFLQYLINFKFSGDIYSFEEGTPIFPNEPILTVKAPVIEAQLIETMILLTLNHQCLIATKSNRIVRAANGNGVMEFGARRAQGYDGAIYGARAAYIGGAIGTATTLAGEIFDIPVFGTMAHSWIQLFDDEFLAFKTYAENYPDSCTLLVDTYSVLGSGVPNAIKVAKEVLEPMGYRLKGIRLDSGDMAYLSRKARKMLDKEGLTDCKIIASNSLDEYTITSLFNQGAKIDLFGVGERLVTSKAEPVFGGVYKLVAVQNESGIAEPRIKISENPEKVSNPGYKRVYRFFDKYSDKALCDVITLATEKIDENKPYTIFDPIHVWKKKKLTNFYIKELQVPIFIKGELVYKSPSLKTIREKCLKEVDTLWDEIKRFENPHAYYVDLSQELWTLKDNLIKKLSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB2</accession>
    <name>A0A386PEB2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">CP523_00285</name>
        <name evidence="7" type="ORF">EI377_10600</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677359.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01176"/>
    <dbReference type="EnsemblBacteria" id="AYE32996">
        <property type="protein sequence ID" value="AYE32996"/>
        <property type="gene ID" value="CP523_00285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61137">
        <property type="protein sequence ID" value="QAS61137"/>
        <property type="gene ID" value="EI377_10600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00285"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE32996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="228" mass="25784" checksum="92E36BFC339885FA" modified="2018-12-05" version="1">MEKYKKEFIEFMVESNVLRFGDFVTKSGRKTPFFINTGNYTTGEQLKKLGEFYAQTINKHFGKDIDILFGPAYKGIPLTVTTAISMNQLYDMNVEYCSNRKEAKDHGEGGILLGAKLKDNSNVVIVEDVMTAGTSIYETAPILKAQGNVNIMGLVISVDRMEKGKSEKSAQEEIKEVFDITTYSIVTMQEVVEHLYMKEINGTIYIDESMKESINSYYEKYGVAYKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC0</accession>
    <name>A0A386PEC0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cation_ATPase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673993.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00500"/>
    <dbReference type="EnsemblBacteria" id="AYE33381">
        <property type="protein sequence ID" value="AYE33381"/>
        <property type="gene ID" value="CP523_02335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="783"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="834" mass="94577" checksum="52D65FC7E99DDF89" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEF4</accession>
    <name>A0A386PEF4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01605</name>
        <name evidence="3" type="ORF">EI377_12125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675682.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33248">
        <property type="protein sequence ID" value="AYE33248"/>
        <property type="gene ID" value="CP523_01605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61420">
        <property type="protein sequence ID" value="QAS61420"/>
        <property type="gene ID" value="EI377_12125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="17064" checksum="71D162A0E8CBAA02" modified="2018-12-05" version="1">MFRLEECVGFITSTASKELSDEFNRRLLLKGSTRVQWIALYYIGNEKGISQKVLADKINVKESTIVRLIDRMEKEGIVKREKEETDRRVTNIFLTEKGENLKEELLPLGEKFSDDITKGIKQEHIDIFNSVLRKMVLNINMNVDNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ6</accession>
    <name>A0A386PEJ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">CP523_08500</name>
        <name evidence="9" type="ORF">EI377_03250</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674848.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01641"/>
    <dbReference type="EnsemblBacteria" id="AYE34465">
        <property type="protein sequence ID" value="AYE34465"/>
        <property type="gene ID" value="CP523_08500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59868">
        <property type="protein sequence ID" value="QAS59868"/>
        <property type="gene ID" value="EI377_03250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08500"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="34792" checksum="E7C67520A19C46C1" modified="2018-12-05" version="1">MITHGKNIKIFTGNSHPELAKEIADILGIPLGRAKVSTFSDGEISVDIDETVRGADVFLVQSTSAPVNNNLMELLIMIDAFKRASAGRVTVVMPYYGYARQDRKAKSRDPITAKLVADLLTAAGAHRVLTMDLHAAQIQGYFNIPVDHLLGSPILAKHFLSRGFDESEDVVVVSPDLGSVTRARKFADKLHAPIAIIDKRRPKANVSEIMNIIGDIKGKRCILIDDMIDTAGTISNAANALKDLGAKNVYACCTHGVLSGPAFERINNSAIEELIMLNTIKLPEKDDLIKFKSLSVAPLFAEAIKRIYDDEPISKLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK3</accession>
    <name>A0A386PEK3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LRR_adjacent domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04995</name>
        <name evidence="6" type="ORF">EI377_15495</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the internalin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01790"/>
    <dbReference type="EnsemblBacteria" id="AYE33877">
        <property type="protein sequence ID" value="AYE33877"/>
        <property type="gene ID" value="CP523_04995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62019">
        <property type="protein sequence ID" value="QAS62019"/>
        <property type="gene ID" value="EI377_15495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012569">
        <property type="entry name" value="LRR-contain_adjacent_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08191">
        <property type="entry name" value="LRR_adjacent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="LRR_adjacent" evidence="4">
        <location>
            <begin position="351"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="52506" checksum="5A5572A7A2D5AC1E" modified="2018-12-05" version="1">MKEEKYMKKKLAISIISTSIIFINILLSTKISADNLNLKENFGQATGDIVNAVSEDGYVDIPDITLRKSLNKALNQNEDDKISKRKLEKLTKFYSMFGEVSNLEGIQYCTNLRELNLQVNKIKDITLLENLTKLRSLSLNVNEIEDISPLSELKELRELYIGYNQIKDLTPLSNLENLKELSIGKLPIDNIEAIKNKPYLMHLSLDSNKLKDLTPIRTLKDLRSISISSSNVENIEFLKDLETVTWVDLHNNNINDITVLKTLPNLSGAVLNDNNIADISPLKDLQDLELVYVDNNNIADITPLKDLTNLKRIKVDNQKVILSSKEVNGRVVIKNPLKHMNGYGKVKGLDNNGEVNESNTYISWNNIKDDTIKNLSFDFNEEVTLGREEIPFSGKVIQPVKFNSNAIKLEDINKNSVVDIDDMAIIASKYNKKHSDENWNEDFDLNKDSIIDILDLVIVSKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER5</accession>
    <name>A0A386PER5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">CP523_07515</name>
        <name evidence="12" type="ORF">EI377_02205</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673804.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01112"/>
    <dbReference type="EnsemblBacteria" id="AYE34300">
        <property type="protein sequence ID" value="AYE34300"/>
        <property type="gene ID" value="CP523_07515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59694">
        <property type="protein sequence ID" value="QAS59694"/>
        <property type="gene ID" value="EI377_02205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07515"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="429" mass="47605" checksum="23A847B7C30AF496" modified="2018-12-05" version="1">MSAFIVLGAQWGDEGKGKMTDYLAEEAQVVVRYQGGNNAGHTVEVGDKQYKLHLIPSGVLYDDKLNVIGNGVVVDPEALFTEIDYLEGEGVKVTPEKLIVSDRAQVIMPYHKVLDKLKEQARGKNDIGTTGKGIGPCYTDKFERCGIRICDLMHKEVFAEKLKENIDMKNAYITKVLGGEALNYDEILEKYLAFAERLRPFVQDTSVRVYDEIKKDKTVLFEGAQGMLLDIDYGTYPYVTSSNTTAGGVANGVGIGPTMITNAVGIAKAYTTRVGKGPFPTELLDSTGDWIREKGHEYGVTTGRSRRCGWLDAVILKTTVRVSGLTSLCVTKIDTLAGLEKLKICVGYKFEDKVIDYFPASLEDLAECEPVYEEFDGWGEEVANARSYEELPENAKKYLRRIEELTETKISIIGVGPKRDQTIRVTEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES9</accession>
    <name>A0A386PES9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">CP523_09045</name>
        <name evidence="8" type="ORF">EI377_03790</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678365.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00248"/>
    <dbReference type="EnsemblBacteria" id="AYE34555">
        <property type="protein sequence ID" value="AYE34555"/>
        <property type="gene ID" value="CP523_09045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59955">
        <property type="protein sequence ID" value="QAS59955"/>
        <property type="gene ID" value="EI377_03790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="14639" checksum="AD7A58EF5DDB91FD" modified="2018-12-05" version="1">MVMTDPIADLLTRIRNANAVRHEVVEVPSSNMKKAVTNILLQEGYIKEIEEYNDGVVPMLRISLKYGANKERVITGIKRISKPGLRVYCKKDETPKVLNGLGIAIISTSKGLLVDREARKAGLGGEVVCYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET4</accession>
    <name>A0A386PET4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gldA</name>
        <name evidence="8" type="ORF">CP523_00260</name>
        <name evidence="9" type="ORF">EI377_10625</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01180"/>
    <dbReference type="EnsemblBacteria" id="AYE32992">
        <property type="protein sequence ID" value="AYE32992"/>
        <property type="gene ID" value="CP523_00260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61140">
        <property type="protein sequence ID" value="QAS61140"/>
        <property type="gene ID" value="EI377_10625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008888">
        <property type="term" value="F:glycerol dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Fe-ADH" evidence="7">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="367" mass="39676" checksum="0631833224CC2D91" modified="2018-12-05" version="1">MSKIIICPNKYVQGKGEIKNLSKHTKNLGKSIFIVASPNGIKRTKVIIEESFNESGCSLVFESFNGECSKKEIDRLGKIIVDNKCDVIVGIGGGKIFDTVKVVAYYKKIPVVIVPTIASTDAPCSALSVIYTEEGIFSEYLLLPKNPDLVLVDTEIIAKSPTRLLMAGIGDALATYFEARACVRSNALNMAGGEITKTALVLAKLCYTTLLEDGFKAKLAVENNVTTKSVENIIEANTFLSGIGFESGGLAAAHAIHNGFTVLEQCHHLYHGEKVAFGTIVQLVLENSPTEEIEEVIKFCIKLGLPVTLEDMGINKIIEEEIKAVADASCAEGETIYNMPFEITSNDVYAAIISANSLGCYYKTNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET6</accession>
    <name>A0A386PET6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07615</name>
        <name evidence="3" type="ORF">EI377_02305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673849.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01132"/>
    <dbReference type="EnsemblBacteria" id="AYE34320">
        <property type="protein sequence ID" value="AYE34320"/>
        <property type="gene ID" value="CP523_07615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59714">
        <property type="protein sequence ID" value="QAS59714"/>
        <property type="gene ID" value="EI377_02305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="253" mass="28455" checksum="8E11BE66A6194812" modified="2018-12-05" version="1">MKKICVFNQKGGVGKTTTNINLCAYLAMEGYRVLTIDIDPQGNTTSGLGLDKRNLELSMYDVLTSDASLNDVILRSELVQNLFIAPSTMELAGAEVEIIGKENRETILTSKIKEIEDQYDFIFIDCPPSLGVLTINALTSVESVLIPIQCEFYALEGVGQLMNTLQLVKKSLNKDLDIEGVIMTMYDYRTNLSNEVYDEVKNFFNEKVYNTKIPRNIRLAEAPSFGLPIMLYDEKCKGANAYKELTKEFLKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV3</accession>
    <name>A0A386PEV3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04435</name>
        <name evidence="3" type="ORF">EI377_14980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676430.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00391"/>
    <dbReference type="EnsemblBacteria" id="AYE33774">
        <property type="protein sequence ID" value="AYE33774"/>
        <property type="gene ID" value="CP523_04435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61932">
        <property type="protein sequence ID" value="QAS61932"/>
        <property type="gene ID" value="EI377_14980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362706" evidence="1">
        <location>
            <begin position="37"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="320" mass="36540" checksum="730F5EE7F21A0775" modified="2018-12-05" version="1">MYRRGYEKIQKQKLYKNVMVGAIVASLSLQGVSTNASSINDSLESDNKTIIQKFTSFMNNIIYKTENILKGNIVNVPDANLKKLLNAALYHEEDEDIMKSDLANIKWLSNIGPEPTLAETNITNLEGIQYCVNLENLLIDVSNIKNLKPMFEIPSLKWIMFDEVKNEQLKGIDSLKNLENFNCEKLDSLEEISKVENLKTLICVNGKIKDIKPLVKLKKLEALWLIDNEIEDISSLENLKQLHALGLQDNNVKDIRALTNLKNIQLLNLDNNNITDISSLSNMEKLAELHLNENDIKDITPLDNLPNLKWLFINNNEIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ3</accession>
    <name>A0A386PEZ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09340</name>
        <name evidence="3" type="ORF">EI377_04085</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678016.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02725"/>
    <dbReference type="EnsemblBacteria" id="AYE34613">
        <property type="protein sequence ID" value="AYE34613"/>
        <property type="gene ID" value="CP523_09340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60013">
        <property type="protein sequence ID" value="QAS60013"/>
        <property type="gene ID" value="EI377_04085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033789520" evidence="1">
        <location>
            <begin position="29"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="33203" checksum="28365FBF7CE6FD97" modified="2018-12-05" version="1">MNKKMAIILTMTTILTMTSGLTTNKIFASELKTENSKLIEGQEGQNGSGGGQAPVLPTNNVQSKKVIITKVTPSKSVISPGEEFSLTYRIENISGGKIDGLSLKLVGVEGKSGLDGFTAVGTTNEIYVGSIAYNDVKEVTIKLVSDPALKTGAYNFVTSVMYSQYGSEQEEITKLSGIVLRSVPEIAINGVETFANQGGSNLTGTLANDSKVKVKNVLVKAKIGDNTYNYSAGNIEAEGEAMFEISIKPVEVDTQGEVEVTYEDVSGNKYTSKGNFMVKPMITEGTEDANSNVKKSGTIMSFLKKLFRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF62</accession>
    <name>A0A386PF62_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09735</name>
        <name evidence="3" type="ORF">EI377_04535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02653"/>
    <dbReference type="EnsemblBacteria" id="AYE34683">
        <property type="protein sequence ID" value="AYE34683"/>
        <property type="gene ID" value="CP523_09735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60084">
        <property type="protein sequence ID" value="QAS60084"/>
        <property type="gene ID" value="EI377_04535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="77"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="499" mass="56993" checksum="1D8AA43CC3BB57B4" modified="2018-12-05" version="1">MKKIIITIISSVLLIVFLLGFVDRVKEAPVESKAVFTYSISAIPQDLKVIGKLDKREQDIICATSRGLVDLGKDGNILPSLAESVEVHDDGLEYDFKIRNDIYWSDGSKITPKDIASFFREILTEEEEASIETILNVYGAREFRSGIGSFNNNVGIRATDTNLIVRLNSKNENFVRELSQPQYKLRKNVLLWQDINNNYKNLIYSGDYSISSMGISEIVLKRNTNIDAKLVETIHIVQDEGEELAMAAFEVGNRDIVINPPKTQLDRLKKENKLITLESNRGIYLAFNPNAESIPTEGKKEIYRLINKAVGEYQMSNTSFVELAEGSYFRNDKDDLAKLQSRKVMSNEVNEWKPSKEIALIAEGSTENKNFCEFLVKWFKKNTEMILTYTLIDKEEMKNVHEETYYNIALIQCEGSLIGENSLFNAMINFLPNNYKDELKNIKNQDERKGKFLSIEDSLFNTYQLLPILFYNDNIAVSNKIKNIVLDGNGNINFNKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF63</accession>
    <name>A0A386PF63_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBECR3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02318"/>
    <dbReference type="EnsemblBacteria" id="AYE33132">
        <property type="protein sequence ID" value="AYE33132"/>
        <property type="gene ID" value="CP523_01005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041301">
        <property type="entry name" value="PBECR3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18812">
        <property type="entry name" value="PBECR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBECR3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="124" mass="14558" checksum="B1385F747998939E" modified="2018-12-05" version="1">MERRFCTYKRVGYFKQIMAESLGLKYTGNIYASPGVLKHIRKRHGRHLSKKVRDNIIETMKNVIEDPDYVGIYKSTEEEILVELIKKIDRNILVGIEIDNNTDYIQVLTMYPITEAKIDSRLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF94</accession>
    <name>A0A386PF94_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08575</name>
        <name evidence="4" type="ORF">EI377_03325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674888.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01656"/>
    <dbReference type="EnsemblBacteria" id="AYE34480">
        <property type="protein sequence ID" value="AYE34480"/>
        <property type="gene ID" value="CP523_08575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59882">
        <property type="protein sequence ID" value="QAS59882"/>
        <property type="gene ID" value="EI377_03325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="15526" checksum="BAC90030FBC815DB" modified="2018-12-05" version="1">MTLMAGKILEGTVVNITNFGAFVEIEGKTGLVHISEVADSFVKDIRQHLKEQDKVKVKVISIDDNGKISLSIKQANVQKKSYKPAEIDWTSENKKNNNSNSGNFEDIMSRFLKDSEERMQDVKKNQDFKSKNSRKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF1</accession>
    <name>A0A386PFF1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS21 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34773">
        <property type="protein sequence ID" value="AYE34773"/>
        <property type="gene ID" value="CP523_10365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="140"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="430" mass="50162" checksum="A312AB255C49F328" modified="2018-12-05" version="1">MIIKVNVNSEIKVNSLVDLHKLKVIMEVNNLKVNKSQIARELGVDARTVGKYLNGYVKPATRNRKSPIDDFKPIIQSLLSEESIQIFYYKRVLWQYLKDNHGLDCAQSSFRRYISNNVEFNDYFKRRKKGYISNKSTMRFETDKGHQAQLDWKENIDFVLSNGEVININIFVLILSYSRFRIYRLSLEKTQDILFSFLNESFEAFGGVPKELLTDNMKTVMDQPRTTYQSGKVNNKFQQFADDYGFKVRPCIAGRPNTKAKVEAPMKLLDEIRAYNGTLNFDELHELILKLNDRINGTCHTSTGKIPVLHLEKEKDFLFALPTEQIRNQYNIITTSVKVNSQSMISYKSNQYSVPPEYIGKKLKLQVYDNQLHLYYSTNLVTIHEIKNQKLNYHNNHYLQISSLTFKNSKYEMNEIAKNNLKMIGEIYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI1</accession>
    <name>A0A386PFI1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Microbial collagenase</fullName>
            <ecNumber evidence="4">3.4.24.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_01745</name>
        <name evidence="16" type="ORF">EI377_12265</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Digestion of native collagen in the triple helical region at Xaa-|-Gly bonds. With synthetic peptides, a preference is shown for Gly at P3 and P1', Pro and Ala at P2 and P2', and hydroxyproline, Ala or Arg at P3'.</text>
            <dbReference type="EC" id="3.4.24.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.24.3" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02402"/>
    <dbReference type="EnsemblBacteria" id="AYE33272">
        <property type="protein sequence ID" value="AYE33272"/>
        <property type="gene ID" value="CP523_01745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61443">
        <property type="protein sequence ID" value="QAS61443"/>
        <property type="gene ID" value="EI377_12265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041379">
        <property type="entry name" value="ColG_subdomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013661">
        <property type="entry name" value="Peptidase_M9_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002169">
        <property type="entry name" value="Peptidase_M9A/M9B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18496">
        <property type="entry name" value="ColG_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01752">
        <property type="entry name" value="Peptidase_M9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08453">
        <property type="entry name" value="Peptidase_M9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00931">
        <property type="entry name" value="MICOLLPTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363055" description="Microbial collagenase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M9_N" evidence="13">
        <location>
            <begin position="56"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ColG_sub" evidence="14">
        <location>
            <begin position="613"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="969" mass="111395" checksum="1710146FA8C6465F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK7</accession>
    <name>A0A386PFK7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Polar amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_01905</name>
        <name evidence="6" type="ORF">EI377_12415</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01167"/>
    <dbReference type="EnsemblBacteria" id="AYE33302">
        <property type="protein sequence ID" value="AYE33302"/>
        <property type="gene ID" value="CP523_01905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61471">
        <property type="protein sequence ID" value="QAS61471"/>
        <property type="gene ID" value="EI377_12415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="25153" checksum="02F4E31814E03AD7" modified="2018-12-05" version="1">MLKITGLKKSFSSIEVLKGIDLEIKPGEIFVIVGPSGGGKSTLLRCVNGLETCDRGTIEIAGKKLCENGKYVDKNTFNEIRRNIGLVFQNFNLFPHMTVLENLIEAMQRVLGENNIDSIKKAEEILGFLGLKDKVNNYPCELSGGQKQRVAIGRALALNPKLMCFDEPTSALDPGLTGEVTNLIKSLGKDGMSMLIITHDMEFAKNVADRIYSMDKGILSEGLIFDNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL3</accession>
    <name>A0A386PFL3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10750</name>
        <name evidence="3" type="ORF">EI377_05535</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674101.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01352"/>
    <dbReference type="EnsemblBacteria" id="AYE34843">
        <property type="protein sequence ID" value="AYE34843"/>
        <property type="gene ID" value="CP523_10750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60237">
        <property type="protein sequence ID" value="QAS60237"/>
        <property type="gene ID" value="EI377_05535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="34540" checksum="B61DDDAB93B3466D" modified="2018-12-05" version="1">MSKFDIKDFKGVIPAVLTVFDKDENIDEVGMRQLVSYLIDKGVDGLYLTGSTGEGFTMSSEERKRVVEIVMDENKGRVPVVVHVGAIGTKLSIDLAKHAESVGADGISSVPPFYWKFNENQIVKYYEEIAKSCSLPMIVYNVPLVGLLGMNTIKRLAAIENVKGIKYTALAHYEITQIKDEIGEDFLVYSGADEMAMSGLLAGADGIVGSFYNIMPELFINIKKAIDNKNIDEAQKLQRYAVEIIMYSLNIPSFYAGMKAVLRWRGINAGYCRSPFENLTEDQEAEFREGYKKLKETYNIVGVDFLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM8</accession>
    <name>A0A386PFM8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33821">
        <property type="protein sequence ID" value="AYE33821"/>
        <property type="gene ID" value="CP523_04705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="208" mass="23991" checksum="F42C91ADFD25B590" modified="2018-12-05" version="1">MEFSDLIKISRKNCSLKLTELESLTGISASYISRIENGINKSPSAEHAISLAEALNIPYEELAKSFLKDKESKIITNQKDRVLIKKGTNILEDISKNKLSLREALEKLVGICTELEKKHIFIVAQNKENKYIVKLPIYDDLLVRKIKELMKIQFKTENISVLEGRVLEMDKCKEYELEEFLKGANEYFMTIDDKEYLEIKGYLNSIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP6</accession>
    <name>A0A386PFP6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_09375</name>
        <name evidence="11" type="ORF">EI377_04120</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02733"/>
    <dbReference type="EnsemblBacteria" id="AYE34620">
        <property type="protein sequence ID" value="AYE34620"/>
        <property type="gene ID" value="CP523_09375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60020">
        <property type="protein sequence ID" value="QAS60020"/>
        <property type="gene ID" value="EI377_04120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="396"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="535"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="791" mass="92406" checksum="6F7F011511DB5ADA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT0</accession>
    <name>A0A386PFT0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ORF">CP523_07395</name>
        <name evidence="10" type="ORF">EI377_02085</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673778.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01088"/>
    <dbReference type="EnsemblBacteria" id="AYE34287">
        <property type="protein sequence ID" value="AYE34287"/>
        <property type="gene ID" value="CP523_07395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59681">
        <property type="protein sequence ID" value="QAS59681"/>
        <property type="gene ID" value="EI377_02085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07395"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="419" mass="44564" checksum="C26DF0F0809260A6" modified="2018-12-05" version="1">MEKLVINGGRALKGSVDINGAKNAAVAILPAAIMASEGKCIIDNVPDIEDVHCLERILKSLGCTVNKVDNNTLEIDATDVHSVNACTEDVRRMRASYYFIGALLSRFGKARVELPGGCPIGVRPIDQHIKGFEALGANVIVENGAVIIEAEHLHSANIFFDVVSVGATINVMIAATLADGTTVLENVAKEPHVVDVANFLNSMGADIKGAGTDVIRIKGVEKLVGCNYSVIPDQIEAGTFMIAAVATKGDVTIKNVIPKHLESITAKLTEMGANVEEGDDSVRVYVDGSLKGINVKTTPYPGFPTDVQQPMSALLSIVPGNSLIVESIWENRHKHTEELNKMGANINVDGRTAAISGVDRLVGARVRATDLRAGAAMVIAGLIAEGKTEIIEIEHIDRGYPNIEFKFTALGADITREAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU1</accession>
    <name>A0A386PFU1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00417"/>
    <dbReference type="EnsemblBacteria" id="AYE33748">
        <property type="protein sequence ID" value="AYE33748"/>
        <property type="gene ID" value="CP523_04305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017241057" evidence="1">
        <location>
            <begin position="27"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="215" mass="24900" checksum="D8B1E45FE7FC2A3B" modified="2018-12-05" version="1">MRNFFKTSLLILTLLALILVPFNVYAITNPSCISDSPEVKCNFKMLERKLWIDHVLWTRSFIVSDIASLEDKNDVLHRLFKNQDDIGNSIKPYYGEEAGNKLAVLLRDHIALAGKVLEAAKNKNKDELDKYNKLWYDNADKIADFLSSANPNYNNKELKDMLYKHLQFVTDQVVARLNNNWKDDIESFDKGENHIINFADIISDGIIKQFPEKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU8</accession>
    <name>A0A386PFU8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase NifS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02460</name>
        <name evidence="4" type="ORF">EI377_12990</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00475"/>
    <dbReference type="EnsemblBacteria" id="AYE33402">
        <property type="protein sequence ID" value="AYE33402"/>
        <property type="gene ID" value="CP523_02460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61576">
        <property type="protein sequence ID" value="QAS61576"/>
        <property type="gene ID" value="EI377_12990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="3"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="381" mass="42581" checksum="EAF8AF3ACF3DE6B9" modified="2018-12-05" version="1">MGIYFDNSSTTKPYEEVINEVVRGMREVYGNPSSLHGLGIKAEKKLNEVREYLSSTINSSKDEIYFTSGGSESNNLIINGLVKSGHHLITTVFEHHSVLKVCERLEKEGVKVTYLDVDEYGRISLEDLKESITKNTVLVSIMHVNNEMGTIQDIESIGKIIKENSSRAKFHVDAVQSYGKLPIDVKKMNIDMLSVAGHKFHGPKGSGFTFIKKGIVLNPLISGGSQESGVRAGTQNLPAIMGLKKAAEMVIENIDYNYKKVLDIKSYMISRLENIKDIRINSPLDKNFTPYILNVSFRGIKAEVLLHLLEEQDIYVSTGSACTSKSSISKGSYVMKSLKISKADIESAIRFSFSEENSKEEVNKVIEVLENSLKFLRRVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW5</accession>
    <name>A0A386PFW5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04455</name>
        <name evidence="3" type="ORF">EI377_14995</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00387"/>
    <dbReference type="EnsemblBacteria" id="AYE33778">
        <property type="protein sequence ID" value="AYE33778"/>
        <property type="gene ID" value="CP523_04455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61935">
        <property type="protein sequence ID" value="QAS61935"/>
        <property type="gene ID" value="EI377_14995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="392" mass="46038" checksum="40471D3274C1C5A3" modified="2018-12-05" version="1">MNIIINELKKIFNIKSILVVGVICFLIYQMFIEFHIKIFPNGYPDTDTYEIAKRIVEEKGVLPKEGLEYLRGIENEYKIKATEYLKENKLAQELGITNYDEYADKVNNIHKKHYESENDMDKKINQLYDDIMFVNKVDAYWNLQGIEGFIMRVRGKKITDNMESLSKSQINRLNEIINSESYNDVLPELVFSNYNEFIINSAILILISVVFFIAPIFTKDKHNKLEYIQYSTKRGRKLYKDKILTSLIATFIIATVELGGLFYLYLTRENTVEMFYNSSINSIFRYKMNWFDVNFKEYIILCVVLVYIFAFAISLITCYISRKSDRYITLTGICILLAILLTSILRSNYMVYSGLGDLYIPRFFIEGILLIILLVGVTLINLRYRKEKRINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG55</accession>
    <name>A0A386PG55_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ruvX</name>
        <name evidence="4" type="ORF">CP523_01150</name>
        <name evidence="5" type="ORF">EI377_11650</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674414.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02288"/>
    <dbReference type="EnsemblBacteria" id="AYE33159">
        <property type="protein sequence ID" value="AYE33159"/>
        <property type="gene ID" value="CP523_01150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61329">
        <property type="protein sequence ID" value="QAS61329"/>
        <property type="gene ID" value="EI377_11650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="15460" checksum="FCF3AD8FA3FDF430" modified="2018-12-05" version="1">MRILGLDVGSKTIGVAISDPLGWTAQGLTTIRRTNREKDIEEVKRICNEYNVETIVIGLPKNMNGSIGESGERVLELSKDIEEATSLKIEMWDERLTTVAAHKAMLEADLSRNKRKKIVDKIAATYILQGYLDRIGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB0</accession>
    <name>A0A386PGB0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03355</name>
        <name evidence="3" type="ORF">EI377_13870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677203.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02112"/>
    <dbReference type="EnsemblBacteria" id="AYE33572">
        <property type="protein sequence ID" value="AYE33572"/>
        <property type="gene ID" value="CP523_03355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61735">
        <property type="protein sequence ID" value="QAS61735"/>
        <property type="gene ID" value="EI377_13870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="18539" checksum="96CE41653EB29C44" modified="2018-12-05" version="1">MGIQEIMQYISQYGMMFLFFIIFLEYLNFPGLGAAIIMPAAGIVASKSGTNFFVALGVSILAGVIASYILYAISYYFGNSILDKIYKRFPKTRKSIEKTYSYVEKYGNKGVLVTRLVPVGRTLIPFVAGTFRMNIVNFTIYSTIGIAIWNAIFIYAGYAFGYFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL6</accession>
    <name>A0A386PGL6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04505</name>
        <name evidence="3" type="ORF">EI377_15045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676412.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33786">
        <property type="protein sequence ID" value="AYE33786"/>
        <property type="gene ID" value="CP523_04505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61943">
        <property type="protein sequence ID" value="QAS61943"/>
        <property type="gene ID" value="EI377_15045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="363" mass="41952" checksum="2208382A36A4634C" modified="2018-12-05" version="1">MKNYLKNSLFITLSMTSILLIFSILISEIINEKGILNMCNYTYKNAITFSINKDDPICKTHENTEVIEEIKLFFSYLMEKDDLVVKSVNGKLFSNGFYTNGLYFNSNYTNNYKLLEGRFLDVSDFKNNNKVAVIPKSALKYVESNNDSKFLYSGSEKYTVVGVIDNGKSNQVKFATIFYNLSLNDINLNMDFDNIVIESDIYSNDELIKLVQDNPYIKIKKIKTDFFYKVSIMDFIKIGVFSFIVIYTPLIIVIFISIILCMYYWVNGIKYEIGVKKLCGANTFDIIKEITIKLIFISTISLTLCPIIQNALEFSNILNRSIIYTSYNFILNILFISLICIVLAIISFYRIDKLELVSLIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP3</accession>
    <name>A0A386PGP3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Permease IIC component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_05980</name>
        <name evidence="12" type="ORF">EI377_00460</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34048">
        <property type="protein sequence ID" value="AYE34048"/>
        <property type="gene ID" value="CP523_05980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59420">
        <property type="protein sequence ID" value="QAS59420"/>
        <property type="gene ID" value="EI377_00460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004796">
        <property type="entry name" value="PTS_IIC_cello"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006351">
        <property type="entry name" value="PTS_EIIC-Cellobiose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00410">
        <property type="entry name" value="lacE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="10">
        <location>
            <begin position="9"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="422" mass="45700" checksum="B6D0AA2591847CEA" modified="2018-12-05" version="1">MMEKFANFLDTKLSTPMAKLAEQRHLRAVRDGIIATLPLIIVGSLFIIIGIPPLPQDWALTQFLKSNAGTIMLPYRMTMYIMTLYATWGIGYSLAKSYKLDGVTGGILAAISFLLTIVPQSVEGAGWMMPMANLGGGGMFVGILTAIFAVEVLRFTTVKNFRIKMPEQVPASVARSFEALTPTAIVVIVMASISYYASFDWHGFIGKIISPLLSATDTLPSVWILIILVTFFWSFGIHGVSIVGSIARPLWLQLLDQNTAAAASGETILPAIAAEPFFQWFIWVGGSGATIGLVICLALFAKSAYGKQLGRAALIPGIFNINEPIIFGAPIVLNPTLIIPFIITPLVTGTLAWFAMSMNLVSRVVVTAPWTLPGPVGAFLATGGDWRASVLNILCIVIAVVIYYPFVKMYDKKLKIEETAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP5</accession>
    <name>A0A386PGP5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678217.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03025"/>
    <dbReference type="EnsemblBacteria" id="AYE35255">
        <property type="protein sequence ID" value="AYE35255"/>
        <property type="gene ID" value="CP523_12935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="177" mass="20302" checksum="EFB0BEB99984D5BE" modified="2018-12-05" version="1">MELGLIHIYCGNGKGKTTAAMGLGMRACGRGYKVLLTQFLKDNDTGELKSIEKLSDNFHVFLGVPMKRFFNYLSEEDKLEVIKEHRERFEKVTKKAVEEKYDLLIMDEIMASLNYGILELDKVVEFLENKPKNLEVVLTGRNPDKKLIDLAHYVSEINPIKHPYEQSKIPARVGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP8</accession>
    <name>A0A386PGP8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="9">2.7.1.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4-methyl-5-beta-hydroxyethylthiazole kinase</fullName>
            <shortName evidence="9">TH kinase</shortName>
            <shortName evidence="9">Thz kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thiM</name>
        <name evidence="10" type="ORF">CP523_12870</name>
        <name evidence="11" type="ORF">EI377_07750</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Thz kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678238.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03037"/>
    <dbReference type="EnsemblBacteria" id="AYE35243">
        <property type="protein sequence ID" value="AYE35243"/>
        <property type="gene ID" value="CP523_12870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60638">
        <property type="protein sequence ID" value="QAS60638"/>
        <property type="gene ID" value="EI377_07750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12870"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000513">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="259" mass="28275" checksum="44452148ACC1EA75" modified="2018-12-05" version="1">MYELINKVKEINPLVLHYTNEVTINDCANITLAVGASPLMSYSYEEVEEIVSIASSIVINIGTMNSNRLDLFVQAAKAANKFNKPVVLDPVGVFATKTRTEFTNRLLNEIKFDVIKGNVSEIKYIGGFDVRGKGVDSFDDGEDITEFIKKVAKKLECVVVATGKVDFISDGERVVKIENGTAKLKFVTGTGCMTASLIGSFLGASDNKLDATAMGVLTMALSGELADKNNIPIGSFKTELMNKVYEMNEEKLSKYGRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ8</accession>
    <name>A0A386PGQ8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_12925</name>
        <name evidence="11" type="ORF">EI377_07805</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678221.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03027"/>
    <dbReference type="EnsemblBacteria" id="AYE35253">
        <property type="protein sequence ID" value="AYE35253"/>
        <property type="gene ID" value="CP523_12925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60648">
        <property type="protein sequence ID" value="QAS60648"/>
        <property type="gene ID" value="EI377_07805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="9">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="7">
        <location>
            <begin position="152"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="8">
        <location>
            <begin position="257"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="741" mass="85712" checksum="D951E4C4372F0F2F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX4</accession>
    <name>A0A386PGX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AEC family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Malate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06455</name>
        <name evidence="7" type="ORF">EI377_00935</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677434.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02168"/>
    <dbReference type="EnsemblBacteria" id="AYE34138">
        <property type="protein sequence ID" value="AYE34138"/>
        <property type="gene ID" value="CP523_06455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59506">
        <property type="protein sequence ID" value="QAS59506"/>
        <property type="gene ID" value="EI377_00935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="355" mass="39329" checksum="E0BFAB8C07207FED" modified="2018-12-05" version="1">MNFLEIIKKTLTDNAIMGAIFSSISIILLGFYLRKKDIMNNAASKILTKVVLTVAIPALAFTSFMKDINEKELNEGLNIMIWGFAVYILLIVLTKLIYSRVKGDKQDVLRVLTIFGSTTFFGVPIVKAVYGATGAMYSSIFNIAYRVFLYSYGYIKMSGMKIEKETFKKNLKEMFLNPVIIATFLGLFIWIFQKSLPQVGIATKDGIVNYAFLRIDQTLPWLYKPLTYLDKLCSPLAWLSIGATLAEVPVKKAVGQKDTWIYSVIKIMLVPVINLVLLVVLSKTGILPVSFEGAATTVIMLATPTATVAAAYAISFDKEAILSSNCSLLSTLFAVVCMPLWIVVLEIVKNIGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH02</accession>
    <name>A0A386PH02_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">recF</name>
        <name evidence="10" type="ORF">CP523_07680</name>
        <name evidence="11" type="ORF">EI377_02370</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673868.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01145"/>
    <dbReference type="EnsemblBacteria" id="AYE34331">
        <property type="protein sequence ID" value="AYE34331"/>
        <property type="gene ID" value="CP523_07680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59727">
        <property type="protein sequence ID" value="QAS59727"/>
        <property type="gene ID" value="EI377_02370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00617">
        <property type="entry name" value="RECF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="361" mass="42183" checksum="B0DAB6D247ABF549" modified="2018-12-05" version="1">MYIKKLQLLNYRNYKVLDIDLGKYVNVFMGDNAQGKTNILEAMYYCAFAKSHRTSRDRELLNWESENAYVSLTIGKDRLDKKIDITILKDGKKAIRINKVKVNKIGELFGTFNVVMFSPEDLKIIKDSPGVRRKFIDMELCQLDSRYYYNLVQYNKVLNERNMVLKNRRLDEEILDIYDIQLSNYGHNIIIDRLKYIDKLNFYGKNIHKDISSGKEEVEFRYISLIKDLDNIENNFYELLKKNRKKDMERGITSVGPHRDDFSTLINGVDTKSYGSQGQQRSAVLTIKFSSLKIIKELTSEYPVLLLDDVLSELDFSRKRYILKTIGEIQTVITCTGIEDLTDYLDQNSKVFKVKNGEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA0</accession>
    <name>A0A386PHA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TetR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14130</name>
        <name evidence="4" type="ORF">EI377_09035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678477.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03102"/>
    <dbReference type="EnsemblBacteria" id="AYE35475">
        <property type="protein sequence ID" value="AYE35475"/>
        <property type="gene ID" value="CP523_14130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60862">
        <property type="protein sequence ID" value="QAS60862"/>
        <property type="gene ID" value="EI377_09035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="199" mass="22902" checksum="E8C29CC2E84AF8EF" modified="2018-12-05" version="1">MSKVEEKKRKKEEILFNTAFNLFSTKGINNTAISDIVKSAGVAKGTFYLYFKDKYDIRDKLITNKTGELFERAILSLKSKNITQFDEQVIFVINYVIDELNKDKLLLRMIARNLSWGIYKKALDRSRQGNAYSYYDLFMENANEKSIKFKNPEVLLFTIIEMVGSTCYSSILYGQPVGIEEFKPHLYESILAILAAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE9</accession>
    <name>A0A386PHE9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09345</name>
        <name evidence="10" type="ORF">EI377_04090</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02726"/>
    <dbReference type="EnsemblBacteria" id="AYE34614">
        <property type="protein sequence ID" value="AYE34614"/>
        <property type="gene ID" value="CP523_09345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60014">
        <property type="protein sequence ID" value="QAS60014"/>
        <property type="gene ID" value="EI377_04090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="327"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="431" mass="47760" checksum="D77988AF3AB1CA11" modified="2018-12-05" version="1">MKFSDLVQIIWKNMWKRRTRTIFTMSGVVIGCLAVFIISSITNGFQKYLTDEMESMMDTSVITLTPYWGAEEGKDKKEGASKKTKLDNKSVEELEKLYFITEVMPKKYTNVSTKLKKTEGFARVLATDFITNKEEDLLFGRYPRKGSKEIVLGYETAKELLGYTWEEKVKDEDEYNSLIGKSVKMGINLGYDEDGKLIDGKKFSAKIVGVLSNGKMEYNYLIQAPIKFVDSIIKSNVNLPKEEIDKMLNTYEEIGVKVDDKSKLEEYEETLKSMGYSTRSLIDFEKQSKSMLLGVTLVLGTLAGISLLVAALGITNTMDMAIYERNKEIGVIKVIGGSLNDVRKIFVGEACAISFTGGSIAIVLGLIVDLIINNVGKSMTQSIMGQPISSIAIPSIGLIIGILTFSLFIGFIAGILPANKAAKTNVITAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI0</accession>
    <name>A0A386PHI0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HDIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07795</name>
        <name evidence="3" type="ORF">EI377_02485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679164.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02108"/>
    <dbReference type="EnsemblBacteria" id="AYE34338">
        <property type="protein sequence ID" value="AYE34338"/>
        <property type="gene ID" value="CP523_07795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59734">
        <property type="protein sequence ID" value="QAS59734"/>
        <property type="gene ID" value="EI377_02485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="46"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="166" mass="19847" checksum="01F33AB06FC7F101" modified="2018-12-05" version="1">MSFYRVKQFLWAIGSTFKKVDYDYLRKYLNEEEIKLFNTLKHNEKHHCIRVCKDSISMKEENNIDVDVMKLGKAALLHDIGKSKFKLNVFEKSIVVLLDKATNGKINRYNNIKQIDIYYNHPKIGEKILRKYNYDEEFLQVIKYHHNNKNTNNRILDIISICDDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK6</accession>
    <name>A0A386PHK6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">CP523_09630</name>
        <name evidence="6" type="ORF">EI377_04405</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676700.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02632"/>
    <dbReference type="EnsemblBacteria" id="AYE34664">
        <property type="protein sequence ID" value="AYE34664"/>
        <property type="gene ID" value="CP523_09630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60064">
        <property type="protein sequence ID" value="QAS60064"/>
        <property type="gene ID" value="EI377_04405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="94" mass="10228" checksum="BDBA1E193937022E" modified="2018-12-05" version="1">MKIKPLADRVVIKKLEAEETTKSGIVLTGTAKERPQEAEVVAVGPGAIVDGKRIEMEVKIGDKVLYSKYAGSEVKVSGEEYTILKQEDILAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL5</accession>
    <name>A0A386PHL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35290">
        <property type="protein sequence ID" value="AYE35290"/>
        <property type="gene ID" value="CP523_13125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="61" mass="6950" checksum="1B1F55709CD94E21" modified="2018-12-05" version="1">MITEKDLKEINENLEGIKQARKLNIKAKSKVNLEDGSEALIYHLGQANKTIRIDIKEISNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL8</accession>
    <name>A0A386PHL8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08040</name>
        <name evidence="4" type="ORF">EI377_02800</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00723"/>
    <dbReference type="EnsemblBacteria" id="AYE34378">
        <property type="protein sequence ID" value="AYE34378"/>
        <property type="gene ID" value="CP523_08040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59784">
        <property type="protein sequence ID" value="QAS59784"/>
        <property type="gene ID" value="EI377_02800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="261" mass="28907" checksum="8908BEFF6D43C492" modified="2018-12-05" version="1">MEKMHAKKYVLITGASLGIGKELCKLYAKDGYNLILVARDIDKLKQLKDELKKYNICVEILSVDLTGDKSCEQVIDFVNKKSLSVDILINNAGIGSFGYLSEIDVNKELSLIDINIRALTELTKYFLKDMIKNNNGAIMNVASTAAFCAGPKMATYYASKAYVLSFTEALYEEVKDKGIKVSCLCPGAVNTTFQGKAGIKKRNGADKNLMSVNKVAEIGYKNFNKGKLIIIPGFKNKLLVLINKLLPRAISRKVILMMNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX7</accession>
    <name>A0A386PHX7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ORF">CP523_13710</name>
        <name evidence="3" type="ORF">EI377_08600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677164.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02080"/>
    <dbReference type="EnsemblBacteria" id="AYE35400">
        <property type="protein sequence ID" value="AYE35400"/>
        <property type="gene ID" value="CP523_13710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62185">
        <property type="protein sequence ID" value="QAS62185"/>
        <property type="gene ID" value="EI377_08600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13710"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="199" mass="22986" checksum="86306F5AEDDFE1E9" modified="2018-12-05" version="1">MIKVGLTGGIGSGKSTVSKMLIEKGFPIIDADVISQDVLKKYPEILEKVKIEFGSGFFDWRGEFRRREFGNHIFRFPKQRKKYEEIIIPYIKKEILEALNEHEKKGSKIVILDAPTLIENNLQNNMDFVILVWVDGNTQIQRIKNRDKLGREEAINRINAQMSLEKKKEFASIILDNNGDLLNTKNQVEGLVEFFKEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ6</accession>
    <name>A0A386PHZ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ORF">CP523_08750</name>
        <name evidence="6" type="ORF">EI377_03500</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678063.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02691"/>
    <dbReference type="EnsemblBacteria" id="AYE34498">
        <property type="protein sequence ID" value="AYE34498"/>
        <property type="gene ID" value="CP523_08750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59900">
        <property type="protein sequence ID" value="QAS59900"/>
        <property type="gene ID" value="EI377_03500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="24106" checksum="464D41DEEA476665" modified="2018-12-05" version="1">MEKGKFIVFEGGDGSGKSTILEMIYNYLKEKGIECVKTREPGGIKISEDIRTIILDTNNTEMDSRTEALLYAAARRQHLVEKVIVALNEGKIVLCDRFVYSSLAYQGYARGLGIDEVFTINKFAIEEYMPDLTILFDVDPQIGLDRIAKNSSREVNRLDLEKLDFHYKVREGYEIVYQNNKDKIIKINAEKSLEEVFEEVKTLILDSIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI05</accession>
    <name>A0A386PI05_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">mscL</name>
        <name evidence="11" type="ORF">CP523_07015</name>
        <name evidence="12" type="ORF">EI377_01760</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01019"/>
    <dbReference type="EnsemblBacteria" id="AYE34222">
        <property type="protein sequence ID" value="AYE34222"/>
        <property type="gene ID" value="CP523_07015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59627">
        <property type="protein sequence ID" value="QAS59627"/>
        <property type="gene ID" value="EI377_01760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="150" mass="16810" checksum="B03ABC8EF2983CE0" modified="2018-12-05" version="1">MKEKGKKFFQEFKEFAMKGNIIDLAVGVVIGGAFNKIVSSLVKDVIMPLVGLLTGGVNFEYLTLVLKAEEGGKPAVTLNYGVFIQNVVDFLIIALSIFIMIKIINRLNRKKEEEKVVEEKKPSKEETLLTEIRDILKESNSCKSIENTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI50</accession>
    <name>A0A386PI50_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M23 family metallopeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">M23 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10225</name>
        <name evidence="4" type="ORF">EI377_05030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674321.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01450"/>
    <dbReference type="EnsemblBacteria" id="AYE34751">
        <property type="protein sequence ID" value="AYE34751"/>
        <property type="gene ID" value="CP523_10225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60151">
        <property type="protein sequence ID" value="QAS60151"/>
        <property type="gene ID" value="EI377_05030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="140"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="27706" checksum="D13B0B1C10A28825" modified="2018-12-05" version="1">MDQNKKDKVKNFFRKEGFYLVLFLCLCLVATVTVVTSKKNKLKQEQAKQSEKEFTLNVDDKTTSEVQKQNADRVQNNTEEKVAQTENETNQEVATTEKDVNVSAGTNSEVKFINPIEGTISRSYSYPKPQGMKDGTSRNIRGIDVKAKVGTDVKAAAVGEVKEVSKRAEEGNYVLIAHANGVNTKYCNLDSDIKVKVGDKVTEETVIGKVGESSKIFTNSEFGEHINLQVQDSNGKDLDPTKYFTYKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI86</accession>
    <name>A0A386PI86_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1653 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10470</name>
        <name evidence="3" type="ORF">EI377_05245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674216.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34791">
        <property type="protein sequence ID" value="AYE34791"/>
        <property type="gene ID" value="CP523_10470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60186">
        <property type="protein sequence ID" value="QAS60186"/>
        <property type="gene ID" value="EI377_05245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="82" mass="9911" checksum="B5A36F497A936D1D" modified="2018-12-05" version="1">MRDILNSRGKIFRHFKGDLYLLEDFVTHSETQEKLVLYRALYGECGLYVRPYNMFLEEVPKEKINPTGQKYRFEEYIVKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI87</accession>
    <name>A0A386PI87_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD</fullName>
            <ecNumber evidence="8">2.1.1.190</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rlmD</name>
        <name evidence="7" type="ORF">CP523_06320</name>
        <name evidence="8" type="ORF">EI377_00790</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.190" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677798.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02423"/>
    <dbReference type="EnsemblBacteria" id="AYE35835">
        <property type="protein sequence ID" value="AYE35835"/>
        <property type="gene ID" value="CP523_06320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62144">
        <property type="protein sequence ID" value="QAS62144"/>
        <property type="gene ID" value="EI377_00790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="453" mass="50999" checksum="C98FADC9617D351B" modified="2018-12-05" version="1">MLEKNKEYTLDIISQGYEGEGIAKVDGYPIFIEGAITGEKVRALIVKVKKNFAYGKLLEVLETSNDRVKPKCNYYKRCGGCSVQHMDYTRQLDFKWDRVKDCVHKIGGLSKELVKYPLGMENPIRYRNKVQLPIGLVNGKLSIGFYAPRSHNIIDLETCLIQDEIADKVVDLTRKWIEDYEISPATIDGKFNPKGLLRHIMIRRGFKTNEVMVVLVTLKDKVPYINEFVKLISENINGIKSIVQNVNPKETNVILGEKCVTLWGNDVITDYIGDFKFNISPLSFFQVNPVQTEVLYGKALEYAGLTGDEIVFDAYCGTGTITLFLSQKAKKVYGVEIVEPAIVNARENAKLNSVGNAEFFVGKSEEVIPELISKGIKPEVIVVDPPRKGCDIKLLEAIGKAKPQRMVYVSCDPSTLARDLKILEEQGFKTEFVQPVDMFPHTSHVECVCVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA1</accession>
    <name>A0A386PIA1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF370 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07685</name>
        <name evidence="2" type="ORF">EI377_02375</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673869.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01146"/>
    <dbReference type="EnsemblBacteria" id="AYE34332">
        <property type="protein sequence ID" value="AYE34332"/>
        <property type="gene ID" value="CP523_07685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59728">
        <property type="protein sequence ID" value="QAS59728"/>
        <property type="gene ID" value="EI377_02375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="86" mass="9692" checksum="D7C94CA053939222" modified="2018-12-05" version="1">MFLHLGENVVVPIKDVIGIFDLQTTMYSSDTSAFLRMAEEDGFVEKISKEKPKSFVIAEVNKMSKVYLSPISSSTLTKRTNIDYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB1</accession>
    <name>A0A386PIB1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35087">
        <property type="protein sequence ID" value="AYE35087"/>
        <property type="gene ID" value="CP523_12045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="41" mass="4702" checksum="9E366CA8778156E7" modified="2018-12-05" version="1">MSRNPSIKCTVNECKYNDQAENYCTLNVIQVGTHEKKPTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF8</accession>
    <name>A0A386PIF8_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">DUF1097 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14765</name>
        <name evidence="3" type="ORF">EI377_09725</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="2" key="1">
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE35590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676127.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01331"/>
    <dbReference type="EnsemblBacteria" id="AYE35590">
        <property type="protein sequence ID" value="AYE35590"/>
        <property type="gene ID" value="CP523_14765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60976">
        <property type="protein sequence ID" value="QAS60976"/>
        <property type="gene ID" value="EI377_09725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009476">
        <property type="entry name" value="DUF1097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06496">
        <property type="entry name" value="DUF1097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="152" mass="16375" checksum="9D13E5465557ACCE" modified="2018-12-05" version="1">MSEIFTLSLMTAILCFGWALGCDFTGLIGFAGFAGCTTFFAAGGRKEGFKTAIFTNVSGIFWAVIIIKLSVLLNISHAGAIMTGIVTFAMCYQSRIKYFTFIPGTFMGCFTTCAANGNWQSVLPSMVFGAVLGVLCESTGKRLYEKLSKKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH7</accession>
    <name>A0A386PIH7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_05450</name>
        <name evidence="8" type="ORF">EI377_16010</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677956.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02578"/>
    <dbReference type="EnsemblBacteria" id="AYE33959">
        <property type="protein sequence ID" value="AYE33959"/>
        <property type="gene ID" value="CP523_05450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62110">
        <property type="protein sequence ID" value="QAS62110"/>
        <property type="gene ID" value="EI377_16010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
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        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="97"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="321" mass="35866" checksum="590B828F2935C1A9" modified="2018-12-05" version="1">MLETGNRVTRFKRKKAKEPAEETSKFNSISKGTNVVLNILFIILAALCIIPFVFVLIISLTSEQALQANGYRFWPQEWSLGAYKYIFSSGSQIMRAYGITIIVTVSGTLLGLAIMSMYGYALSRKSFAYRKFFTKLIFIPMLFSGGMVSSYLVVTRFLGLKNNILALILPMCVSSFNIIILRTFFKTTVPDAIVESAKIDGASEWKLFLKIVLPISLPGIATIALFLTLGYWNDWFNAMLYIDDNSLMPLQYLLIRIESSIEFLANNAALMGANALEASANMPKDTAKMAIVVITTLPIIFAYPFFQRYFVNGLTIGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP5</accession>
    <name>A0A386PIP5_CLOSE</name>
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        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_13005</name>
        <name evidence="5" type="ORF">EI377_07880</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677811.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02541"/>
    <dbReference type="EnsemblBacteria" id="AYE35267">
        <property type="protein sequence ID" value="AYE35267"/>
        <property type="gene ID" value="CP523_13005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60662">
        <property type="protein sequence ID" value="QAS60662"/>
        <property type="gene ID" value="EI377_07880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="305" mass="34051" checksum="3C2174843294E656" modified="2018-12-05" version="1">MKIGLVLSGGGGKGAYELGVWKALNELNIAKYIDVFSGASIGAFNAVLFAQNDMNAAERLWEEVTMEKLAPVSKAILIKKGVELAVGWKCINFAKRYMCQSLESGIVSKDGAIDIINRYLKVGEVKKRGKICYAACTKLPDFKAEYFKINDYDDELGKNIVIASASLPRIYDCTEILGNKYIDGGVSDNTPIQPVYDEGCDIIIVVLLSKISEINKRLYPNAKIIEIIPKTLNENTIKGTLNLDKISKEKRISEGYIDTINLLQPIIALGEIKKENEVLENKKSFLKMYSWAKRLLLEKENRNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ0</accession>
    <name>A0A386PIQ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase class I/II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11815</name>
        <name evidence="4" type="ORF">EI377_06635</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02921"/>
    <dbReference type="EnsemblBacteria" id="AYE35044">
        <property type="protein sequence ID" value="AYE35044"/>
        <property type="gene ID" value="CP523_11815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60437">
        <property type="protein sequence ID" value="QAS60437"/>
        <property type="gene ID" value="EI377_06635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="339" mass="39056" checksum="F9487259285EFE3F" modified="2018-12-05" version="1">MQNKGKEQSIMLNNNESYIHLEEELVFKSILELKNISFNRYPDENAEKLKSEYAKYANINCSNIIVCNGNYEILDLILRSKLVKEKRILTLNPDCAIEDAYCINNKFNCIRFKSDEDGKFDISKFIIFGMKKDIDLVVISNPNNPTGNNISNDDIVKILKSFRSSIVLIDESYFEFSSDTCISLIDEYENLLITRTLSNGWGLAGIKIDFLIGNIETIKKLKNNTIIKSVNSLSQSVATRILSNSNDMKSKFQEIIKQRDIFYYKLKDIEDESSLEIKFYKSKGNYIYGRSPYKNVLLKAMHNKGIIIKSFDDDSFRITVGSKLQNEKVIEALKKSFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR6</accession>
    <name>A0A386PIR6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplX</name>
        <name evidence="8" type="ORF">CP523_09030</name>
        <name evidence="9" type="ORF">EI377_03775</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876950.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00246"/>
    <dbReference type="EnsemblBacteria" id="AYE34552">
        <property type="protein sequence ID" value="AYE34552"/>
        <property type="gene ID" value="CP523_09030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59952">
        <property type="protein sequence ID" value="QAS59952"/>
        <property type="gene ID" value="EI377_03775"/>
    </dbReference>
    <dbReference type="GeneID" id="66300465"/>
    <dbReference type="KEGG" id="csep:CP523_09030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="11385" checksum="D509BF63A0C1F734" modified="2018-12-05" version="1">MKVHVRKNDTVVVISGKDKGKTGEVLKVSPKTGKVIVQGVNIVKKHQKPNRANAQGGIIEKEGAIYSSKVMLYCTKCKNATRISNKILEDGTKVRVCKKCGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ7</accession>
    <name>A0A386PIZ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fis family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_07180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01051"/>
    <dbReference type="EnsemblBacteria" id="AYE35840">
        <property type="protein sequence ID" value="AYE35840"/>
        <property type="gene ID" value="CP523_07180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="110"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="441" mass="49432" checksum="7D4515979D1C7360" modified="2018-12-05" version="1">MSFSLLGHIEYINDIAKELLGLHDDSCSNINIIYEYPSLFKLLSNNNKDLCVYENIFIPKTNRNLSCHISPIYENCKVQGYIIVFKNINHPINLDNKFSTFQAKYTFEDIIGQSPQIKKVINECKAISKNSSAVLLNGESGSGKELLAQSIHNYSDRSNGPFIAVNCGAIPKNLIESELFGYESGSFTGAKKGGAPGKFELANGGTIFLDEIGEMPLEMQVTLLRVLQESCVTRIGGKNSIDIDVRVIAATNKDLKEEIKNCNFRSDLYYRLSVLPIKVPPLKERIGDVPVLLNHFLNIKSKKLNKSIPKISQNLFKKMISYCWPGNIRELENFVENLVALNGVTTYEIDLAECHCLTYDNLGNIIDTYSLNETPPKIPTNNITPLLALEQAEIKKAICICNGNMTKAASKLGISRNALYNKIKRYNINTNECKISYDEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ20</accession>
    <name>A0A386PJ20_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4173 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12765</name>
        <name evidence="4" type="ORF">EI377_07640</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35224">
        <property type="protein sequence ID" value="AYE35224"/>
        <property type="gene ID" value="CP523_12765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60619">
        <property type="protein sequence ID" value="QAS60619"/>
        <property type="gene ID" value="EI377_07640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025231">
        <property type="entry name" value="DUF4173"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13777">
        <property type="entry name" value="DUF4173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4173" evidence="2">
        <location>
            <begin position="395"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="618" mass="71515" checksum="08BE7D9E2ADE0C5D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ72</accession>
    <name>A0A386PJ72_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02447"/>
    <dbReference type="EnsemblBacteria" id="AYE35507">
        <property type="protein sequence ID" value="AYE35507"/>
        <property type="gene ID" value="CP523_14290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="340" mass="39274" checksum="754C5124BB226508" modified="2018-12-05" version="1">MNKTNIKCPRCHSNNLYKFGLDKQANQKYQCQNCKRQFAPDKVSSRVLKNYPRCPKCGKGTYLHHSYKHYNSYKCNNKKCNHIIVNHHNFNIDPASSEDITGSLSMKGIRFPLQVIITVLTLYYLNNTSTRAISQFLMSTFNIKVSHVTVANCSNKFAPYFKLKVDKFKHQVDLQSDDWHADETIVFINGIKHYLWLVIDSETRFIVSFHLSKYSDENSAFSLINEAKKYGSPSNLVTDRWPAYNEAIATLLPNKKHLPVKPMSSDINNNLIESFNKTFKAWYKSKKGFNSFQKANNLIFMFIFHYNFIRSHGSLNNLTPAEVAGFASNNISRQSWFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ80</accession>
    <name>A0A386PJ80_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase sigma factor SigI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sigI</name>
        <name evidence="2" type="ORF">CP523_14350</name>
        <name evidence="3" type="ORF">EI377_09260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Negatively regulated by the anti-sigma-I factor RsgI.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RsgI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. SigI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02460"/>
    <dbReference type="EnsemblBacteria" id="AYE35517">
        <property type="protein sequence ID" value="AYE35517"/>
        <property type="gene ID" value="CP523_14350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60902">
        <property type="protein sequence ID" value="QAS60902"/>
        <property type="gene ID" value="EI377_09260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02064">
        <property type="entry name" value="Sigma70_SigI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014244">
        <property type="entry name" value="RNA_pol_sigma-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30385:SF6">
        <property type="entry name" value="PTHR30385:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038953">
        <property type="entry name" value="SigI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Polymerase core binding" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="25975" checksum="068DA2B3417B0EB9" modified="2018-12-05" version="1">MINDVERSLGKDYRGDINFLIEEYMPFIIKSISETTGKYVSLENSEELSVGLLAFNEAVEKYEDNRGGFLSFCKLVISSRIKNYLKRENKENNKVSFEELIAQGIEIKEDHTNVGEDKEELLREINILKSEIGEFGFTLDDLVEEAPKHEDTRRNALKLSEKVSKVKELTDHLFEKKRLPIKKISLRFTVTEKVIKRSKKFITTGIIIYYKNFRNLKLWIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJC8</accession>
    <name>A0A386PJC8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14690</name>
        <name evidence="4" type="ORF">EI377_09655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678850.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00136"/>
    <dbReference type="EnsemblBacteria" id="AYE35577">
        <property type="protein sequence ID" value="AYE35577"/>
        <property type="gene ID" value="CP523_14690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60963">
        <property type="protein sequence ID" value="QAS60963"/>
        <property type="gene ID" value="EI377_09655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3" evidence="2">
        <location>
            <begin position="13"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="27306" checksum="4DD227797E37F81C" modified="2018-12-05" version="1">MERYNKIRGKNQREIVLLKGFPCVWGKCKFCDYIHDNGIDKEESNKINKEVLDKIDGEFGVLEVINSGSCFELPKETLNYIKKIIEKKKIKKLFLESHWCYRKRLDEMRSLFNIPIIFKIGVETFDNDFRNNVLNKNAKFKSEDEVKKYFQSVCIMVGIKGQTKEMIKRDIDIVLKNFNYATINVFIENSTPIKRDNELIEWFYREYKFLEDYNNIEVLYHNTDFGVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJF8</accession>
    <name>A0A386PJF8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome partitioning protein ParB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">ParB/RepB/Spo0J family partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07610</name>
        <name evidence="5" type="ORF">EI377_02300</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673842.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01131"/>
    <dbReference type="EnsemblBacteria" id="AYE34319">
        <property type="protein sequence ID" value="AYE34319"/>
        <property type="gene ID" value="CP523_07610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59713">
        <property type="protein sequence ID" value="QAS59713"/>
        <property type="gene ID" value="EI377_02300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="287" mass="32950" checksum="A5B5ADD905B82FB1" modified="2018-12-05" version="1">MSKKFALGKGLGALIPEDMVTAPTNEKKEESSKTLISINLIKSNSDQPRKFFDDDKIAELAESIKHHGIIQPIILKKNKEDYIIVAGERRWRAAKLLGLKEVPAIVMNLTDKDILEISLIENIQRQDLNPIEEAVAYKKLLGEFKLTQEELSRRIGKSRVAISNTMRLMNLTETVQQYLMDGVITEGHGRVLLAISDENLQCEIAQKVIDEKLSVRELEKFIKFLNKPKKNIERKIENSPYYKDVTERLQEFLGTKVNISNKNNKGKIEIEYYSDEDLQRILEIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ7</accession>
    <name>A0A386PJJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10440</name>
        <name evidence="2" type="ORF">EI377_05215</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34786">
        <property type="protein sequence ID" value="AYE34786"/>
        <property type="gene ID" value="CP523_10440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60181">
        <property type="protein sequence ID" value="QAS60181"/>
        <property type="gene ID" value="EI377_05215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="93" mass="10474" checksum="CC4DC266DE1F9A4D" modified="2018-12-05" version="1">MRAVNAKVIARRQNGVDVKFSNGMRDFIASIDKENLTIEDIKNYSVNVKVYSIIRNCCNAYPANVLELGTSKSDDEEIKDLLDKIVDMVGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL0</accession>
    <name>A0A386PJL0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3783 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12210</name>
        <name evidence="2" type="ORF">EI377_07030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673570.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35118">
        <property type="protein sequence ID" value="AYE35118"/>
        <property type="gene ID" value="CP523_12210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60509">
        <property type="protein sequence ID" value="QAS60509"/>
        <property type="gene ID" value="EI377_07030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="140" mass="15905" checksum="E3A5AB5B8154C4F6" modified="2018-12-05" version="1">MSFERIDIKNTEIEEGRSCIFLCNFSGKELKMVENYAGVIGIKDRVVLSYKNGDSKIKNIVDGKILSECTEGPNNRAIIFNNISQFKIGMFIENLKKIKVRNVLFAAVTETSKEWTLNNLIENLVQERKAMQSGTSIHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP5</accession>
    <name>A0A386PJP5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02523"/>
    <dbReference type="EnsemblBacteria" id="AYE34882">
        <property type="protein sequence ID" value="AYE34882"/>
        <property type="gene ID" value="CP523_10945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="25"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="272" mass="31521" checksum="68778CAE42DB039E" modified="2018-12-05" version="1">MFSIVIVNWNGAKLLNQCLDSLIEKYKKSLLIETIELDKNYGFAYANNIGIDKAMKDENEYIVTLNNDIEVTNDTLDILKRYIENNRNVDIFQLMMINYYERNKIDAAGLEFDENYFVMPLGYNKDKSEIENLQIEIEGACAGAAVYSKKALLSVKEMEIDYFSSDFFAYFEDVDLALRLKSKGFKTHLVKEAIVYHMHSATGNKSSNFKDYYLSRNLFKYFKRNLSIKQYNISSKKGYKLMGKMFARYLVKGNLGGAKSILKGMVDYKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJQ3</accession>
    <name>A0A386PJQ3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ORF">CP523_08310</name>
        <name evidence="10" type="ORF">EI377_03055</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01603"/>
    <dbReference type="EnsemblBacteria" id="AYE34429">
        <property type="protein sequence ID" value="AYE34429"/>
        <property type="gene ID" value="CP523_08310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59832">
        <property type="protein sequence ID" value="QAS59832"/>
        <property type="gene ID" value="EI377_03055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="33"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="280" mass="31990" checksum="30F25367A9D040AE" modified="2018-12-05" version="1">MDIQDVKTAELVKKYNFKFSKSLGQNFLIDDSVPRDIVNGAEVDENDLVIEIGPGVGTLTAQLLKRAKKVVAIELDNDLIPILQQEIGDNPKFTLIHNDALKVDFNEIIGEEKSVKLVANLPYYVTTPIIVKLLKEDYKFKSLTIMIQKEVAERMNAEPGNKDYGALSLLVQYYCNTSIVRRVPPQCFIPRPKVDSIVIRLERLEEPKVKVENEKLFFDIIRSSFNMRRKTLWNGVKSLGLDKEKLEIAFENANIDPKRRGETLSIEEFACLSDKINEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJQ6</accession>
    <name>A0A386PJQ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14005</name>
        <name evidence="3" type="ORF">EI377_08910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678637.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35451">
        <property type="protein sequence ID" value="AYE35451"/>
        <property type="gene ID" value="CP523_14005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60839">
        <property type="protein sequence ID" value="QAS60839"/>
        <property type="gene ID" value="EI377_08910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26265" checksum="B85179C0C3C79985" modified="2018-12-05" version="1">MGKKHRDPDSTQGDENIVVEQNIQSVEGENIAQGFNNNSEKNANTTSESTAGQGTSNANNTTTGSTTGKSTSNDSTTPQGKTLNERFNNMSTLVDRVNAFQNNIASLNVGGDDERIFYDRKIRPLLDEMFFLSQSAQSMAIASQNMQSIAFAKKKQIKLPVDLSYEIVKEIYCMFEILKKRNSIYRRIIEDDLERCNMPFDNCYESSFLDLDEECFKDMKNYYNNFYCDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR1</accession>
    <name>A0A386PJR1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01999"/>
    <dbReference type="EnsemblBacteria" id="AYE35188">
        <property type="protein sequence ID" value="AYE35188"/>
        <property type="gene ID" value="CP523_12570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025883">
        <property type="entry name" value="Cadherin-like_b_sandwich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="Pectate_lyase_SF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12733">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pectate_lyase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate_lyase_3" evidence="2">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin-like" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1398" mass="156825" checksum="9B783FCE2C6F2A42" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU2</accession>
    <name>A0A386PJU2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnz</name>
        <name evidence="10" type="ORF">CP523_14440</name>
        <name evidence="11" type="ORF">EI377_09415</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676821.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02481"/>
    <dbReference type="EnsemblBacteria" id="AYE35534">
        <property type="protein sequence ID" value="AYE35534"/>
        <property type="gene ID" value="CP523_14440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60921">
        <property type="protein sequence ID" value="QAS60921"/>
        <property type="gene ID" value="EI377_09415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="34975" checksum="EBD93295CB424214" modified="2018-12-05" version="1">MLDICLLGTGGGMPMPFRGLSATLISYKGRKILIDCGEGTQVSMRMIGWGFKSIDIICITHVHGDHIIGLTGLLSTIGNSGRTEKLTIIGPKGINKVVNGLRVIVEYLPYELEIIEYPREVNFKLTNNGLEVSESGDITLSTLDLEHSAPCLGYKIYFKRNRKFNVEKAIENNVPKILWSKLQKEEKACLNGIEYLSDMVLGEERKGIYISVITDTRPIESIKDFVKYSDLFICEGTYGKDEDIEKAIKNRHMTFREAATLAKDGSVKTLLLTHFTPAMMNPDEYINNAKEVFKNTIIAKDRLIINLKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJW6</accession>
    <name>A0A386PJW6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11115</name>
        <name evidence="4" type="ORF">EI377_05905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00917"/>
    <dbReference type="EnsemblBacteria" id="AYE34916">
        <property type="protein sequence ID" value="AYE34916"/>
        <property type="gene ID" value="CP523_11115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60310">
        <property type="protein sequence ID" value="QAS60310"/>
        <property type="gene ID" value="EI377_05905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014578">
        <property type="entry name" value="Pesterase_CT488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033094">
        <property type="entry name" value="Pesterase_CT488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="26759" checksum="EF91AAD6C74466AD" modified="2018-12-05" version="1">MALYAISDLHLAFSTDKPMDIFGEKWYKHDEKIKKNWMDKVKEEDLVLIAGDISWSMKAEESKSDLDFIDSLPGKKIISKGNHDYWWQGITKLNKMYENTKFLQNNFYTYKDYAICGSRAWICPGTDRFTEKDKKIYERELIRLKLSLDSAKNSGYTKFIVMIHYPPTNEKHEDSAFTELFKEYGVDKVIYGHLHGPSLGNVINGERDGVEYIMTSCDYINFDPKLILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX9</accession>
    <name>A0A386PJX9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="4">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF</name>
        <name evidence="3" type="ORF">CP523_11415</name>
        <name evidence="4" type="ORF">EI377_06230</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673277.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02840"/>
    <dbReference type="EnsemblBacteria" id="AYE34972">
        <property type="protein sequence ID" value="AYE34972"/>
        <property type="gene ID" value="CP523_11415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60365">
        <property type="protein sequence ID" value="QAS60365"/>
        <property type="gene ID" value="EI377_06230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="337" mass="37038" checksum="D70A206C83CF6873" modified="2018-12-05" version="1">MIIVMNSKCTESELQKVKMEVESTGLGTYLSKGETFCIVGVIGEAMELDSDKLLRFQGVEKVLKVQEPFKKANRLFKPEDTVIDVNGSLIGGENLAVMAGPCSVESEEQIIEIAKSVKESGATFLRGGAFKPRTSPYSFQGLELEGLELLKKARAVTGLPIVTEIMSTDYIDKFISDVDIIQVGARNMQNFDLLKQLGKTNKPILLKRGLSSTIEEWLMSAEYIMAGGNENVILCERGIRTFETYTRNTLDLSAIPMVKKLSHLPVIVDPSHAGGYWYLVEPLAKAAISAGADGLMIEVHNNPQCALSDGQQSIKPESFKKMMDKIKLLAKIEGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJY9</accession>
    <name>A0A386PJY9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14785</name>
        <name evidence="2" type="ORF">EI377_09745</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676119.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01327"/>
    <dbReference type="EnsemblBacteria" id="AYE35594">
        <property type="protein sequence ID" value="AYE35594"/>
        <property type="gene ID" value="CP523_14785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60980">
        <property type="protein sequence ID" value="QAS60980"/>
        <property type="gene ID" value="EI377_09745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="130" mass="14883" checksum="69627F3BC01DD1A2" modified="2018-12-05" version="1">MSFVKLEKNYETKIRYRMSSRDVYYGGGIVNGARSITLLGDVAEKLMCKIYGNFGRCIELENVRLHAPVFAGDYIEFIGRVVEIDEKIAKIECRSYKIAAIPEKPKFKSSIEIYEEPTLSSSFVGYFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ4</accession>
    <name>A0A386PJZ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oleate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11470</name>
        <name evidence="3" type="ORF">EI377_06285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.53" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673300.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02851"/>
    <dbReference type="EnsemblBacteria" id="AYE34982">
        <property type="protein sequence ID" value="AYE34982"/>
        <property type="gene ID" value="CP523_11470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60375">
        <property type="protein sequence ID" value="QAS60375"/>
        <property type="gene ID" value="EI377_06285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="572" mass="65055" checksum="AA3D2D64C679D5A1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ9</accession>
    <name>A0A386PJZ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11330</name>
        <name evidence="6" type="ORF">EI377_06150</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02823"/>
    <dbReference type="EnsemblBacteria" id="AYE34956">
        <property type="protein sequence ID" value="AYE34956"/>
        <property type="gene ID" value="CP523_11330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60351">
        <property type="protein sequence ID" value="QAS60351"/>
        <property type="gene ID" value="EI377_06150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11330"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="261" mass="29387" checksum="0F814196D978A407" modified="2018-12-05" version="1">MEINCKDIEVKYGDYKAVKGVDAALYKGVITTIIGPNGSGKSTFLKAITRLLRRSNGSVHINDKSIEEFKGKDLSKMIAVLPQRHCAPPDFKVEELVSYGRMPHKKWYDTKTDYSDQIVNWAMECTNVSHLKKKSINEISGGEAQRVWIATVLAQNPDILFLDEPTTYLDISHQLETMNLVKKLNIEHGIGVVMVLHDLSHALEVSDRIIVLKNGEKYDEGAPIDVITSKMMKEVYNVDCDIIKIEGRNKPIIAYKEIIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK75</accession>
    <name>A0A386PK75_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrous oxide-stimulated promoter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12070</name>
        <name evidence="2" type="ORF">EI377_06900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673490.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02971"/>
    <dbReference type="EnsemblBacteria" id="AYE35092">
        <property type="protein sequence ID" value="AYE35092"/>
        <property type="gene ID" value="CP523_12070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60485">
        <property type="protein sequence ID" value="QAS60485"/>
        <property type="gene ID" value="EI377_06900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020483">
        <property type="entry name" value="Uncharacterised_YgbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11756">
        <property type="entry name" value="YgbA_NO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="97" mass="11821" checksum="56B9CDDAA44E4B65" modified="2018-12-05" version="1">MNRIEKEKDVVELMIKLYCRKKHNCRGELCKECKELLEYAHKRLDLCRFGNSKTSCSKCKIHCYKKDMKINIKEVMRFSGPRLIIYEPYEFIRHIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE2</accession>
    <name>A0A386PKE2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TDT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_15630</name>
        <name evidence="7" type="ORF">EI377_10345</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678621.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00565"/>
    <dbReference type="EnsemblBacteria" id="AYE35751">
        <property type="protein sequence ID" value="AYE35751"/>
        <property type="gene ID" value="CP523_15630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61088">
        <property type="protein sequence ID" value="QAS61088"/>
        <property type="gene ID" value="EI377_10345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="35895" checksum="17A5B19B4BAD30B0" modified="2018-12-05" version="1">MSNKDILSKEKLKNLPIGVMATLLGTLTLSNVFAMLGFNSLRHLAVNIGVVIILAGFMKLFLHPKQVFTEMDDTVLGSIYPTFCMSMMLMAAYYVKYNFTLGKSLWLFAVSLNVIVLIIFTYNNLIKKFEINKFLPPYFVPYVGIIVAVITSTAMKAPVITKVIFYFSFIAYFIILPFMIYRLATKPVADLPYPTLCIMAAPPSLCVVAYLTLFKEANVYLTLFVYLIVILCCIYMYTRLPKILRMKFTPSFAGITFPLAISTLATFKVSALMNDIGQATFSNILRELGSLQLILASAGILFVIYNFIKLLIDSFKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM5</accession>
    <name>A0A386PKM5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlmB</name>
        <name evidence="3" type="ORF">CP523_08870</name>
        <name evidence="4" type="ORF">EI377_03625</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678123.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02714"/>
    <dbReference type="EnsemblBacteria" id="AYE35851">
        <property type="protein sequence ID" value="AYE35851"/>
        <property type="gene ID" value="CP523_08870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62158">
        <property type="protein sequence ID" value="QAS62158"/>
        <property type="gene ID" value="EI377_03625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="2">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="301" mass="33622" checksum="7892E418C81810CF" modified="2018-12-05" version="1">MERKNARLEREIFSRNKNNTKRDFKEPRKGREYGETQNSQRYIDNKEGYDKKESPIREDLIIGRNAVMEGLKSDRTIECLYIAKGDVEGSIKAIINIAKEKKVVIKEVDRKKLDSMSEGLNHQGAIALVTPFKYCQVHDILAIAKEKNEDPFIIILDEIEDPHNLGSIIRTAELCGAHGIIIPKRRNVGITSTVYKCSVGAIEHMNIAKVTNINAVIDELKESGVWIYGADIAGVEYSYQVNFNGPCAIIIGSEGRGISKLTLKKCDKLVKIPMIGKINSLNASVAGGIMMYEVLKGRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKW3</accession>
    <name>A0A386PKW3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UvrD_C_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_13315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00759"/>
    <dbReference type="EnsemblBacteria" id="AYE35326">
        <property type="protein sequence ID" value="AYE35326"/>
        <property type="gene ID" value="CP523_13315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UvrD_C_2" evidence="9">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="369" mass="43114" checksum="117E8C3D1EE4125E" modified="2018-12-05" version="1">MEDTVFKLSDIENEINEEENRKKESQLLEMDKVIQITIRDCDEKQLNILGSSLDEYLVTGPAGSGKSMIAMIKAMELYNNNNKFRIIIYTKALSEFIIGKLKRVDIKNIKDYILCGYEFQKEDISEDIDYIIIDEVQDFNLKNIEYCRNMAKKGCFLFGDDLQQIYPKNTDGKNIIKNLIDSDIKLFKLEKTYRFPKKIAFFSELIKDNHGDISNLCIEEGGDENTPRMIEFKNRDAEMTYIVDTIKNEGWKDVGILVRNNDMAQIVYDELRKKGCICDYKIKDEMKLDFTNDNPKILTYHSSKGLEFERVFIPQCDVDEDDSTNLNLREALYVACTRTSKTLILSYIKSFKSPFLNGINSKYYKFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKZ2</accession>
    <name>A0A386PKZ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4355 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678789.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03086"/>
    <dbReference type="EnsemblBacteria" id="AYE35688">
        <property type="protein sequence ID" value="AYE35688"/>
        <property type="gene ID" value="CP523_15310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025580">
        <property type="entry name" value="DUF4355"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14265">
        <property type="entry name" value="DUF4355"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="215" mass="23694" checksum="24363A22DBDF4813" modified="2018-12-05" version="1">MKRKLIMNLQLFGLGRISRPFLNADAGDGNGSAGTGTDNSNGEGAGEQGESKTFDDVLKDKSYQSEFDKRVAKALETAKSKWETEKATELENAKTEAEKLAKMNAEQKAKYAEEKRLAELEKREKDITTRELKAQAYETLAEKNLPKELIGTLNFSDAEQCNKSIEAVEKAFQSAVEKAVNDKLRGGNTPKGGQGNNNQTTFGFNFTGVRSRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL45</accession>
    <name>A0A386PL45_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">moaA</name>
        <name evidence="14" type="ORF">CP523_15675</name>
        <name evidence="15" type="ORF">EI377_10390</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678608.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00556"/>
    <dbReference type="EnsemblBacteria" id="AYE35758">
        <property type="protein sequence ID" value="AYE35758"/>
        <property type="gene ID" value="CP523_15675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61097">
        <property type="protein sequence ID" value="QAS61097"/>
        <property type="gene ID" value="EI377_10390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15675"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="255"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="323" mass="37256" checksum="BCEE873086D4DA6C" modified="2018-12-05" version="1">MKDRFGRNIDYLRISVTDNCNLRCIYCMGEKNNKFLNLDEKLTNEEIYKIVCEFSKLGIKKIRITGGEPLVRKDILKLIEDINKIDGIEEIYITTNGILLLDYIETLAKNGVKGVNISLDSLKYDRFKNITRGGELNKVLKAIDKCIENNIKVKLNTVIIDEINKDEILDFVNLTITKPIDIRFIELMPIGEGKKFKPVTNSEILSIIKNKYKNLKEFKREKSSGPAKYIKIDNSIGKVGFISAISNCFCSECNRIRLTPDGFLKQCLHFNYGVNLRELLRQGITEEKLKNLISENIYNKPEKHLFNENNKDEEIRFMNEIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLF4</accession>
    <name>A0A386PLF4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_14735</name>
        <name evidence="16" type="ORF">EI377_09695</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676138.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01337"/>
    <dbReference type="EnsemblBacteria" id="AYE35586">
        <property type="protein sequence ID" value="AYE35586"/>
        <property type="gene ID" value="CP523_14735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60971">
        <property type="protein sequence ID" value="QAS60971"/>
        <property type="gene ID" value="EI377_09695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="324"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="483"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE35586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS60971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="602" mass="69615" checksum="C1139CA4D137DD58" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLF7</accession>
    <name>A0A386PLF7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35712">
        <property type="protein sequence ID" value="AYE35712"/>
        <property type="gene ID" value="CP523_15430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="124" mass="14501" checksum="AEC86C26DEE8046C" modified="2018-12-05" version="1">MKVLLSIKPQYVQRIFNGEKKFEYRKTLFKRKDIDSILVYATKPIGKVVGEFKIGTIIEDSPEFIWELTKNNSGIKRDDYEKYFEGRSIGFAISIKKPKIYKTPLELSELNPNIKVAPQSFMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLQ9</accession>
    <name>A0A386PLQ9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endopeptidase La</fullName>
            <ecNumber evidence="3">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lonB</name>
        <name evidence="7" type="ORF">CP523_11870</name>
        <name evidence="8" type="ORF">EI377_06690</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673435.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02932"/>
    <dbReference type="EnsemblBacteria" id="AYE35862">
        <property type="protein sequence ID" value="AYE35862"/>
        <property type="gene ID" value="CP523_11870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60448">
        <property type="protein sequence ID" value="QAS60448"/>
        <property type="gene ID" value="EI377_06690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014251">
        <property type="entry name" value="Spore_LonB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02902">
        <property type="entry name" value="spore_lonB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="91"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="6">
        <location>
            <begin position="347"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="553" mass="60736" checksum="498209DF118D1441" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLS5</accession>
    <name>A0A386PLS5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_14050</name>
        <name evidence="10" type="ORF">EI377_08955</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00227"/>
    <dbReference type="EnsemblBacteria" id="AYE35459">
        <property type="protein sequence ID" value="AYE35459"/>
        <property type="gene ID" value="CP523_14050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60847">
        <property type="protein sequence ID" value="QAS60847"/>
        <property type="gene ID" value="EI377_08955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="411"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="668" mass="77039" checksum="9DE282F6D0AADD43" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM16</accession>
    <name>A0A386PM16_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="5 9">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_15640</name>
        <name evidence="12" type="ORF">EI377_10355</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678631.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00563"/>
    <dbReference type="EnsemblBacteria" id="AYE35896">
        <property type="protein sequence ID" value="AYE35896"/>
        <property type="gene ID" value="CP523_15640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61090">
        <property type="protein sequence ID" value="QAS61090"/>
        <property type="gene ID" value="EI377_10355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15640"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8 9" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="10">
        <location>
            <begin position="176"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="44201" checksum="847F10BD1EC4244A" modified="2018-12-05" version="1">MRKFVSLEDAIDILNRNILPLDTEIISLMDSVNRTVKNNIYSKIDNPPFNKSAMDGYAIKASNLENTKLKIIDKVYAGSFSKKEIKDFETIRIMTGAPIPLGANAVIKQEDVIVEGEFIKLKKSLKENENICFKGEDIKKDQLLIKANRKLNYADIGILASSGISEVKVYKKPRIAIISTGDEVLDVIEELTLGKIYNSNRYSIMARIKELGYDVSLIKHVKDSKLEISEELKDISSKVDLIITTGGVSVGEKDLINEAVNIAGGTRLFWKIKIKPGSAVLCSKLNKALVISLSGNPTAALTTFELLVKPSLEKLNGKEELSIVREKAILYDDINKKSPQRRFIRGHLVTNEKGQIVKITQKKSGNGILSSTLNSNCIVEIEEGSLGVKKGELVNIIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB70</accession>
    <name>A0A386PB70_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC</name>
        <name evidence="8" type="ORF">CP523_01225</name>
        <name evidence="9" type="ORF">EI377_11725</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674368.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02273"/>
    <dbReference type="EnsemblBacteria" id="AYE33173">
        <property type="protein sequence ID" value="AYE33173"/>
        <property type="gene ID" value="CP523_01225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61343">
        <property type="protein sequence ID" value="QAS61343"/>
        <property type="gene ID" value="EI377_11725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01225"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="450" mass="50311" checksum="5BE90A0478973D14" modified="2018-12-05" version="1">MLKKVLIANRGEIAVRIIRACRELGILTVAVYSEADKEALHTQLADEAVCIGPPLAKDSYLNIANILSACVLTGADGIHPGFGFLSENPRFAKMCAECNIKFIGPDFEAIELMGNKARAREIMKEAGVPVVPGYEGIIENEDHALNIANEIGYPVMVKASAGGGGKGIRIVRCEEEFKLAYNTAKAEAKACFGDDRIYIEKFVEKPRHIEFQILADEYNNVIHLGERECSLQRKNQKVLEEAPSTFLNEDLRMEMGEVAKKAAKAVNYKNAGTIEFLVDKYGNYYFMEMNTRIQVEHPITEMITDVDLVKEQLKIASKIPLNLKQEDIKILGHAIECRINAEDPSNDFRPCPGTIKELCMPAGMGVRIDSAIYCGYKIPHNYDSMIGKLITFAKTRDEAIIKMKRSLAEFGIGGVTTNIDFQYWLIQQEEFLRGEYDTSFLAEKMVKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBA9</accession>
    <name>A0A386PBA9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00480</name>
        <name evidence="8" type="ORF">EI377_10970</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676308.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00625"/>
    <dbReference type="EnsemblBacteria" id="AYE33030">
        <property type="protein sequence ID" value="AYE33030"/>
        <property type="gene ID" value="CP523_00480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61199">
        <property type="protein sequence ID" value="QAS61199"/>
        <property type="gene ID" value="EI377_10970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="235" mass="27662" checksum="958337F247E28852" modified="2018-12-05" version="1">MVKILIADSENLEIEALKLIIQRKFKEVKVIATANCSDELIEKVEYINPDIIFIDMLIYGLNSFDVIRYIKKTYVNKKIVIMSIYDDFYFVRKALKLKVDDYLLKPIKVENVVEILNEFINIDKDYSINNELKFVLNYIEKNLKGNIMLQDIASCMNVSTSYLSKSFKNKMGTNFNKYVTKRKIEEAKYILKSTDISISDLTFNIGYNEPNYFCKVFKKVEGMTPLEYRELYKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBI3</accession>
    <name>A0A386PBI3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">16S rRNA (Guanine(966)-N(2))-methyltransferase RsmD</fullName>
            <ecNumber evidence="4">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsmD</name>
        <name evidence="3" type="ORF">CP523_00890</name>
        <name evidence="4" type="ORF">EI377_11385</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.171" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674558.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02341"/>
    <dbReference type="EnsemblBacteria" id="AYE33110">
        <property type="protein sequence ID" value="AYE33110"/>
        <property type="gene ID" value="CP523_00890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61280">
        <property type="protein sequence ID" value="QAS61280"/>
        <property type="gene ID" value="EI377_11385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="183" mass="20743" checksum="83ABE8A047819D98" modified="2018-12-05" version="1">MRIIAGKARGRKLIPPATMETRPTLDRVKEAMFSIIQGYVPDSVVIDVFAGTGSLGLEAASRGAKEVYLVDKSQITFPLLKENIENLKFEDFCTGLNMDSYEALRTLAKKDKVFDIIFIDPPYCKEMIPEAIKIVKENNLLKENGIIVTKIDSIEDIYEGFEDIILIRSKKYGNTTICFYKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBT1</accession>
    <name>A0A386PBT1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamate 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">eam</name>
        <name evidence="10" type="ORF">CP523_02425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673968.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00482"/>
    <dbReference type="EnsemblBacteria" id="AYE33395">
        <property type="protein sequence ID" value="AYE33395"/>
        <property type="gene ID" value="CP523_02425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016869">
        <property type="term" value="F:intramolecular transferase activity, transferring amino groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030801">
        <property type="entry name" value="Glu_2_3_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00290">
        <property type="entry name" value="glutamate_2_3-aminomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04368">
        <property type="entry name" value="Glu_2_3_NH3_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="152"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="421" mass="48979" checksum="B5F8DECD5630894F" modified="2018-12-05" version="1">MVENYQRKISLERAEKLRNNIQDYLDVKDLIRCGLRENEILKIKERKNKILNYFGASEKEWNDWKWQLKNRIDNVDVVKGIIELEDSEFEAIKNVGKKYRWAITPYYLSLIDEDKFNPIRLQALPLGIELETDGELDPMKEEFTNPAGCITRRYPDRLIINVTNECAMYCRHCQRRRNIGAVDKHKSTNKLQESIDYIRENPEIRDVLITGGDSLTLSDEMLDWLLGELRKIDHVEIIRLGTRTLVTMPQRVTDNLVKIISKYHPIYINTHFNHPLEITSETKNACEKLANAGVPLGNQAVLLNEINNDKYVMRLLNQELLKIRVRPYYIFHGKHVKGTTHFNTSIDDGIEIMEYLRGYTSGLAIPTFIVNAPGGKGKTPILPQYLISRGKGYVTIRTWEGEVIEYSDHETKDFKSLLINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCB2</accession>
    <name>A0A386PCB2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00060</name>
        <name evidence="2" type="ORF">EI377_10540</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678955.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00301"/>
    <dbReference type="EnsemblBacteria" id="AYE32954">
        <property type="protein sequence ID" value="AYE32954"/>
        <property type="gene ID" value="CP523_00060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61126">
        <property type="protein sequence ID" value="QAS61126"/>
        <property type="gene ID" value="EI377_10540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="rRNA_methylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276">
        <property type="entry name" value="PTHR35276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="20600" checksum="FA5B36B0C3F859C1" modified="2018-12-05" version="1">MFRYVANISDLSHYIIKDFLERKNIAIDATLGNGHDTDFLSEIFNKVYSFEIQKDPCELYNKKALNNVEVINDSHDKFIEYINDNVDCIMYNLGFLPGGNKEITTLHETSIKSIKQGLEILNPGGIMTICIYKGHDEGKKEESCILEYIKTLPKNKFGVMSHSYLNRNKTAPSLIVIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCC0</accession>
    <name>A0A386PCC0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_02555</name>
        <name evidence="10" type="ORF">EI377_13090</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673929.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00456"/>
    <dbReference type="EnsemblBacteria" id="AYE33420">
        <property type="protein sequence ID" value="AYE33420"/>
        <property type="gene ID" value="CP523_02555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61594">
        <property type="protein sequence ID" value="QAS61594"/>
        <property type="gene ID" value="EI377_13090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="16516" checksum="2E780EC1C222A5BB" modified="2018-12-05" version="1">MAIEKDKDGNKGKKIIVIILALVVVGAATFAAVYFAESKKVSAGEVVIEESYNDLGEVFINLSDEGGRRYAKLSASIGYDKSNEELGKEIEDKKVAIRDTAIYYFKSCKAKDFNAESETNLKGELVKRINQKLRTGAIRDVYIKDIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCI0</accession>
    <name>A0A386PCI0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnfE</name>
        <name evidence="8" type="ORF">CP523_01295</name>
        <name evidence="9" type="ORF">EI377_11795</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675558.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00810"/>
    <dbReference type="EnsemblBacteria" id="AYE33187">
        <property type="protein sequence ID" value="AYE33187"/>
        <property type="gene ID" value="CP523_01295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61357">
        <property type="protein sequence ID" value="QAS61357"/>
        <property type="gene ID" value="EI377_11795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="24988" checksum="4B157CF7C6BCC633" modified="2018-12-05" version="1">MKDFRERLKNGIITENPIFVQVLAMCPTLAVTTNAKNALGMGLASTVVLIFSNMIISALRKLIPEKIRIPAYIVIIASFVTIVDMLMQGYVPSLYNSLGIFIPLIVVNCIILGRAESYASKNKVFPSIFDAIGMGLGFTVALFSIGTVREILGAGQILGYQILPEAFKPASIMILAPGAFFTLGALMTLLNFINIKKAEKTGEKAKTLEHNCGSCSGCGTGSCSKESIEIGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCL2</accession>
    <name>A0A386PCL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04020</name>
        <name evidence="2" type="ORF">EI377_14540</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02782"/>
    <dbReference type="EnsemblBacteria" id="AYE33695">
        <property type="protein sequence ID" value="AYE33695"/>
        <property type="gene ID" value="CP523_04020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61850">
        <property type="protein sequence ID" value="QAS61850"/>
        <property type="gene ID" value="EI377_14540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="279" mass="31521" checksum="D8F9C126B71064A9" modified="2018-12-05" version="1">MKYKMICIDMDGTLLGKGREISEENKKIIKEAHDEGAEIVVTTGRIYNNAAYFSNILGVKSPVIAANGAIIREKHDSKIIYKNTIPIEVCIRLVKLLYKNKMHFHFYTTDSIYCSNNLIKLGTEIFMTKQIGYDSLKINYHVEKTLKGWEELFNRLGDNITKCIAFSTNKKKIKNFKEELNKVDEVVYFGSGSFSIEINHKGVSKGNAVQELAKYYGFNKDEIMCIGDNENDLSMIQYAGLGIAMGNAIDAVKKAADYITDTNKRHGVGKAIKKFVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCP4</accession>
    <name>A0A386PCP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01600</name>
        <name evidence="3" type="ORF">EI377_12120</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675680.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00873"/>
    <dbReference type="EnsemblBacteria" id="AYE33247">
        <property type="protein sequence ID" value="AYE33247"/>
        <property type="gene ID" value="CP523_01600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61419">
        <property type="protein sequence ID" value="QAS61419"/>
        <property type="gene ID" value="EI377_12120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="117" mass="12920" checksum="7C71A81B529C04AE" modified="2018-12-05" version="1">MKKDPRQMLNDFMQGLNSVGETNGENVQAFMNLLGATYSEGKLTTKTKELISVAIAAYNRCEYCIVFHVYKALEAGANREEIMEAAMVAVAFGGGPSMAYSTTLLKDSIDEFEKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCT5</accession>
    <name>A0A386PCT5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Ribokinase</fullName>
            <shortName evidence="10">RK</shortName>
            <ecNumber evidence="3 10">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">rbsK</name>
        <name evidence="13" type="ORF">CP523_03520</name>
        <name evidence="14" type="ORF">EI377_14045</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + D-ribose = ADP + D-ribose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="3 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677923.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02255"/>
    <dbReference type="EnsemblBacteria" id="AYE33600">
        <property type="protein sequence ID" value="AYE33600"/>
        <property type="gene ID" value="CP523_03520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61764">
        <property type="protein sequence ID" value="QAS61764"/>
        <property type="gene ID" value="EI377_14045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03520"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="D_ribokin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02152">
        <property type="entry name" value="D_ribokin_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="12">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="33325" checksum="223DDB079DBD13BA" modified="2018-12-05" version="1">MNKICVLGSINMDLVLQIENMPKVGETILSNGFEKIPGGKGANQAVAAKRSGASVYMISKIGKDDNGQLLLKKLIDDNINTKYVLIDEKEPTGMAMIMVNKNGNNSIIVVPGSNMTINREDIKASKEAIIESDILISQFETPVDVTLDAFRIAKNLNKITILNPAPAKSIDDELLKYTDIIIPNETEAELITGVKVDDLESAKVAASKIIEKGVKFVIITLGSKGAAIISKNEAKIVDAFKVNAIDTTAAGDSFIGGLSSKLNTSELTFENLIEAVRFGNKVSSIAVQRKGAQPSIPYLKEVLEVYKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCX2</accession>
    <name>A0A386PCX2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2812 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04725</name>
        <name evidence="3" type="ORF">EI377_15235</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01726"/>
    <dbReference type="EnsemblBacteria" id="AYE33825">
        <property type="protein sequence ID" value="AYE33825"/>
        <property type="gene ID" value="CP523_04725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61971">
        <property type="protein sequence ID" value="QAS61971"/>
        <property type="gene ID" value="EI377_15235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021359">
        <property type="entry name" value="DUF2812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11193">
        <property type="entry name" value="DUF2812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="242" mass="28256" checksum="E414B64B39EDBD65" modified="2018-12-05" version="1">MKKKYVMIRGLAFSEEDDMEKLKNYASQGWILEDIVVGIFYKLRKDKPQNIVYNLDYQTETNEEYFTMFKEAGWKLVVSIENYMHIFSAQVGTKPIYSDCESEIDKYTSIRNTTRKGTLYSLIIAIALMGLLVVSLMVIKPIFLIILGLLIIDIFIFVFNFMPYLAYNSRIKQIKKYGKCNSKTIDNKISWKLYGIAGVLWLAIGIWHLIGELYFSSVFFIIFGAFFIFLSSSYFKKYKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCZ8</accession>
    <name>A0A386PCZ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3784 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04925</name>
        <name evidence="3" type="ORF">EI377_15425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675734.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33863">
        <property type="protein sequence ID" value="AYE33863"/>
        <property type="gene ID" value="CP523_04925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62006">
        <property type="protein sequence ID" value="QAS62006"/>
        <property type="gene ID" value="EI377_15425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017259">
        <property type="entry name" value="UCP037672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12650">
        <property type="entry name" value="DUF3784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="111" mass="12725" checksum="33004D951140AE3D" modified="2018-12-05" version="1">MNIGAITCLTLSILFGIFSAIFALFKENAAIFISGFNTIPKEEREKYDKKKMSIDMRNSLFLWCIILLLGAIASYFIGNYCAIIAIIIWLILFFKNVHIDLDKAFSKYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDA9</accession>
    <name>A0A386PDA9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">feoB</name>
        <name evidence="14" type="ORF">CP523_01975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678256.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01153"/>
    <dbReference type="EnsemblBacteria" id="AYE33314">
        <property type="protein sequence ID" value="AYE33314"/>
        <property type="gene ID" value="CP523_01975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="13">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="586" mass="64827" checksum="435DB72F4B50E470" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDE6</accession>
    <name>A0A386PDE6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05805</name>
        <name evidence="2" type="ORF">EI377_00290</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674975.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01861"/>
    <dbReference type="EnsemblBacteria" id="AYE34015">
        <property type="protein sequence ID" value="AYE34015"/>
        <property type="gene ID" value="CP523_05805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59387">
        <property type="protein sequence ID" value="QAS59387"/>
        <property type="gene ID" value="EI377_00290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="257" mass="30066" checksum="689BF40E79A12823" modified="2018-12-05" version="1">MSINKFYKLLDLMKTKYYMKFKQKSFKGKKYTINYLLDKNKSSDILLVVFTSCTKKGQKARYNYIRTLENFKVNKLFILDDFGFDGRGAYYLGKDKDFKIQLDVSSLIDSVSNDLNIKKEVFIGSSKGGYAALYFGLNRTNSIIISGAPQYRLGNYLSLPGHEEILQYIMGDTKEYSIDYLNKLLEDKLNSTCNNKNKIYLHYSTEEETFEPEIEPLINKIKELNLDHSFDIHNYKNHSDLTLFFPQYIKDVLSKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDK9</accession>
    <name>A0A386PDK9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">CP523_00790</name>
        <name evidence="18" type="ORF">EI377_11285</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674611.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02362"/>
    <dbReference type="EnsemblBacteria" id="AYE33091">
        <property type="protein sequence ID" value="AYE33091"/>
        <property type="gene ID" value="CP523_00790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61260">
        <property type="protein sequence ID" value="QAS61260"/>
        <property type="gene ID" value="EI377_11285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="22"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="129"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE33091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS61260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="237" mass="27160" checksum="CDA2C4BC39FF2750" modified="2018-12-05" version="1">MKINILTLFPEMFEIFNHSIIGKAKEKELIQINAINIRDFTLNKHKKVDDYPYGGGAGMVMAPQPLVDAIRFCKKSSNSKVIFLGPKGKTFNQEIAGELSKEKDLTFICGHYEGIDERVYKHIDMEISLGDFILTGGEMAAIPVIDSILRLVPGVLGKEESYIDESFSDGLLEYPQYTRPELFEGDRVPEVLLSGHHENIRKWRRLQSLIVTKKRRKDLYEKVKLTKEDIKMLNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDL2</accession>
    <name>A0A386PDL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_06215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34093">
        <property type="protein sequence ID" value="AYE34093"/>
        <property type="gene ID" value="CP523_06215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="340" mass="38860" checksum="E3376F9CECD76CE4" modified="2018-12-05" version="1">MNKANIKCPGCHSNKLYKFGLDKQANQKYQCKKCKRQFAPDSVSNPIKSKYPRCPKCNKATFLHHEYKHYNRYKCGNKKCNHIIVKHHTTNIDIASNELITGSLSMKGMRFPLHVILTALTLYFLNNSSTRAISQLLMINSGIKVSHVTIASWTNKFAPFFKQKADKFKASLNLQSDDWHADETVVFINSERYYLWLAIDSETRFILAFHLTKSRSSDSAYILVNEAKKFGEPVSFITDRLPSYNEAVATLLPNTTHIPVAPMSSDINNNLIESFNKTFKAWYKTKKGFNSFQKANNLIYLFIFHYNFIRPHGSLNNCTPAEVAGFASDSFAKNSWFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDN7</accession>
    <name>A0A386PDN7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06390</name>
        <name evidence="5" type="ORF">EI377_00865</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677792.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02437"/>
    <dbReference type="EnsemblBacteria" id="AYE34125">
        <property type="protein sequence ID" value="AYE34125"/>
        <property type="gene ID" value="CP523_06390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59492">
        <property type="protein sequence ID" value="QAS59492"/>
        <property type="gene ID" value="EI377_00865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="449" mass="50475" checksum="8AC39E1260BEEEA8" modified="2018-12-05" version="1">MNIKDWLKPGVRVKRWFFFGIFGILLIAFGFTELVNHRIYDTYYKLFYIFLNVTGIFVIYISVVEGMKSIIALSNKGYIKLSLDSKKMESLIYEKRLLVKGPKIVVIGGGTGLSTMLRGLKYYTSNITAIVTVADDGGGSGVLREDLGMLPPGDIRNCILALADTEPLMEELLQYRFPDGRLKNQSFGNLFLAAMDGVSDNFEAAIQKMSSVLAVTGKVLPVTLDDMKLIAKLENGNEVDGESQIPQEVIKQNSRIDKLMINPKDARPLEDALKAIRDADAIVLGPGSLYTSVIPNLLVKDIADTIKKSSALKIYISNIMTQPGETDGFKVSDHIKVLKKHAGKNIVDYVIANRESIPEDVKDKYLEDKSELVELDRKELKALGVEVVEASLVKIEKKYVKHDSEHLAEVLVDTIMEKKLLYDRKKIIEYMYLSQRIKEKEEKNKQNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDR6</accession>
    <name>A0A386PDR6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11 12">Uridine kinase</fullName>
            <ecNumber evidence="7 11 12">2.7.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytidine monophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Uridine monophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">udk</name>
        <name evidence="14" type="ORF">CP523_01110</name>
        <name evidence="15" type="ORF">EI377_11610</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + cytidine = ADP + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11 12">
            <text>ATP + uridine = ADP + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 11 12">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 11 12">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7 11 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674439.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02296"/>
    <dbReference type="EnsemblBacteria" id="AYE33151">
        <property type="protein sequence ID" value="AYE33151"/>
        <property type="gene ID" value="CP523_01110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61321">
        <property type="protein sequence ID" value="QAS61321"/>
        <property type="gene ID" value="EI377_11610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01110"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00551">
        <property type="entry name" value="Uridine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026008">
        <property type="entry name" value="Uridine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="13">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="205" mass="23540" checksum="361CED61CEBABC29" modified="2018-12-05" version="1">MKKPILIGITGGTGSGKSTIADEIYSSFADECIAMIQQDMYYKDQSHLTMEERVKTNYDHPRAFDNELLIKHLKALMEGKAIEKPIYDFAKHNRAEETVRVEARDIIIVEGILVLEDERIRDLLDIKVYVDTDADIRILRRLVRDINERGRTVESVIDQYLGVVRPMHLQFTEPTKRYADIIVPEGGQNKVAIDILVTKIKDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDS3</accession>
    <name>A0A386PDS3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(Deoxy)nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_03605</name>
        <name evidence="5" type="ORF">EI377_14135</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677727.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02224"/>
    <dbReference type="EnsemblBacteria" id="AYE33617">
        <property type="protein sequence ID" value="AYE33617"/>
        <property type="gene ID" value="CP523_03605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61781">
        <property type="protein sequence ID" value="QAS61781"/>
        <property type="gene ID" value="EI377_14135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="14962" checksum="F783A41453F42306" modified="2018-12-05" version="1">MKKLIKVVGAIIENDNQEILCALRSKDMSVSKFWEFPGGKVEDGESIGDAIVREIKEELDCTVEFMDIFNDNTHEYENVIVNLIVTRCKLVQGTPKANEHAKLLWLHTDYIESLTWAPADIPAMKQLAKSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDZ3</accession>
    <name>A0A386PDZ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07155</name>
        <name evidence="2" type="ORF">EI377_01910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673718.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01046"/>
    <dbReference type="EnsemblBacteria" id="AYE34245">
        <property type="protein sequence ID" value="AYE34245"/>
        <property type="gene ID" value="CP523_07155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59651">
        <property type="protein sequence ID" value="QAS59651"/>
        <property type="gene ID" value="EI377_01910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="142" mass="16383" checksum="54E750816F9F2B7D" modified="2018-12-05" version="1">MKISTKGRYGLRALIDISIYSFSETVTLKSISERQDISERYLEQIFSSLRKGGVIKSKKGPQGGYFLSEEANNLTIGEILRILEGDSNLINIEETDNEMEKFICENLWEVANKRIKDFFNSITLEELSTKYKESTVNIMYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDZ5</accession>
    <name>A0A386PDZ5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_07070</name>
        <name evidence="7" type="ORF">EI377_01815</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01030"/>
    <dbReference type="EnsemblBacteria" id="AYE34233">
        <property type="protein sequence ID" value="AYE34233"/>
        <property type="gene ID" value="CP523_07070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59638">
        <property type="protein sequence ID" value="QAS59638"/>
        <property type="gene ID" value="EI377_01815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07070"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DHFR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="162" mass="18510" checksum="5F366342E100982F" modified="2018-12-05" version="1">MLSIIVAKANNSIIGGDNKLLWHISEDLKRFKEITSGNIIIMGRKTFQSLPGILPNRKHIVITRDTNFKVDSDMVEVYNNLNDVISNYKNSENEAFIIGGGEIYKALLPHSNKLYLTIINKDFEGDTKFPEINLNDWNIDFKSEEKIDSKNGLKYTFINLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE40</accession>
    <name>A0A386PE40_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1576 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06090</name>
        <name evidence="3" type="ORF">EI377_00570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34070">
        <property type="protein sequence ID" value="AYE34070"/>
        <property type="gene ID" value="CP523_06090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59441">
        <property type="protein sequence ID" value="QAS59441"/>
        <property type="gene ID" value="EI377_00570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011470">
        <property type="entry name" value="DUF1576"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07613">
        <property type="entry name" value="DUF1576"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="413" mass="44946" checksum="F8EE7EED1E8FF3E4" modified="2018-12-05" version="1">MSIKKKLYPPYTVLIIMYVFFIIFAFAVNSPKEILSGLKNILFTPDILITDYIEIGGIGATFVNAALTSLASIAILVLIGIKPNGSTIMALYLMTGFSFFGKNILNIWPIMIGVYLFSKYQKEPFLNYTLVALLATTLAPTVSQLSFTGHFSQFGGILLGYGLGIFTGFILSPIASHCIKSHNGYNLYNIGFAGGLLATLLMSILRSIGINFDTRLIWHTGSNKIFSIFLFIISIYLIIVGLIYGNNNKNKLISISKQPGRLISDFYILFGETSYINMGILGIASTVFVLLIKGDLNGPTMAAIFTIMGFGCFGKHLRNITPIIIGASIASLLHISPINSPNLILSILFSTALAPISGKFGWKFGILAGFLHLNIVTNIGYLHGGLNLYNNGLAAGFVAMILIPLITTFKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE42</accession>
    <name>A0A386PE42_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04185</name>
        <name evidence="6" type="ORF">EI377_14710</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676855.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02748"/>
    <dbReference type="EnsemblBacteria" id="AYE33727">
        <property type="protein sequence ID" value="AYE33727"/>
        <property type="gene ID" value="CP523_04185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61884">
        <property type="protein sequence ID" value="QAS61884"/>
        <property type="gene ID" value="EI377_14710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="245" mass="27665" checksum="6415893837EE7A3D" modified="2018-12-05" version="1">MININGLKKSYDKFDVLKGIDLEVKKGEIVTIIGPSGSGKSTFLRCLNYLEEPTEGMIQINDIKVDAKNHTNDDIHNLRKHSGMVFQQFNLFNNKTVLENVMEGLIIVKKLNKKESEEIALEALKKVNMDNKKDVYPKNLSGGQKQRVSIARAIAMNPEVILFDEPTSALDPELVSEVLTVIKNLAKEHRTMIIVTHEMSFAKEISDKIVFIDNGGIIEQGTPEEVLLNPKEDRTKEFLSNVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB5</accession>
    <name>A0A386PEB5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04575</name>
        <name evidence="3" type="ORF">EI377_15125</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675832.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33797">
        <property type="protein sequence ID" value="AYE33797"/>
        <property type="gene ID" value="CP523_04575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61954">
        <property type="protein sequence ID" value="QAS61954"/>
        <property type="gene ID" value="EI377_15125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="88" mass="10336" checksum="9FBE17DE8F6FE6E8" modified="2018-12-05" version="1">MDIILEELFTLVLDGCFEIITNKKINSIIRKIVFWFITSFYMGIVIIFTMLAIKSNSIVVKIIYMVISMLFLLFFSRLGIKLYKNKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH8</accession>
    <name>A0A386PEH8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33654">
        <property type="protein sequence ID" value="AYE33654"/>
        <property type="gene ID" value="CP523_03810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="113" mass="12734" checksum="6266C10A7C1712FE" modified="2018-12-05" version="1">MYLSKFTDYSFRALIYLAINKDRLCTVEEIASNLEISENHLKKIIHKLAKTDYIISIKGRAGGLKLGLEPKDINLGEVLKVTEDNLNIAECFNKEKTCPFIKGGCKLKGIMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI2</accession>
    <name>A0A386PEI2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">CP523_01775</name>
        <name evidence="16" type="ORF">EI377_12295</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677319.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02396"/>
    <dbReference type="EnsemblBacteria" id="AYE33278">
        <property type="protein sequence ID" value="AYE33278"/>
        <property type="gene ID" value="CP523_01775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61449">
        <property type="protein sequence ID" value="QAS61449"/>
        <property type="gene ID" value="EI377_12295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01775"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="58"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="171"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="333" mass="36359" checksum="12D021261C8194F7" modified="2018-12-05" version="1">MITYKEAGVNIEEGYRSVKLIKEYASRTMSEYVLNGLGSFAGMVELPEGYKKPVLVSGTDGVGTKLDIAFKTKKYDTVGIDCVAMCVNDILCHGAKPLFFLDYIACGKLEAEVAADLVKGVSEGCIQGDCALIGGETAEMPGFYRDGEYDMAGFAVGIVDKDKIINGKNIKEGDKLIGITSSGIHSNGYSLVRKIFTDLNEDLNGQEIWKTLITPTKIYVKPVLELLKSFEIKGMSHITGGGFIENVPRMFNGNNLTAVIKKNSYPLSAIFERIMEKGVDENHMYNTFNMGIGFILCVKESDVEGIIKKLIEMGEKAYEIGYITSGGEGCCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEL6</accession>
    <name>A0A386PEL6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="7" type="ORF">CP523_08635</name>
        <name evidence="8" type="ORF">EI377_03385</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01668"/>
    <dbReference type="EnsemblBacteria" id="AYE34485">
        <property type="protein sequence ID" value="AYE34485"/>
        <property type="gene ID" value="CP523_08635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59887">
        <property type="protein sequence ID" value="QAS59887"/>
        <property type="gene ID" value="EI377_03385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08635"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="556" mass="60510" checksum="F9A0308BECA6413D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER4</accession>
    <name>A0A386PER4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">CP523_01135</name>
        <name evidence="13" type="ORF">EI377_11635</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674421.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02291"/>
    <dbReference type="EnsemblBacteria" id="AYE33156">
        <property type="protein sequence ID" value="AYE33156"/>
        <property type="gene ID" value="CP523_01135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61326">
        <property type="protein sequence ID" value="QAS61326"/>
        <property type="gene ID" value="EI377_11635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="364"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="555" mass="61473" checksum="57DFB10B31ACA9F8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET1</accession>
    <name>A0A386PET1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05390</name>
        <name evidence="4" type="ORF">EI377_15950</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677980.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02591"/>
    <dbReference type="EnsemblBacteria" id="AYE33947">
        <property type="protein sequence ID" value="AYE33947"/>
        <property type="gene ID" value="CP523_05390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62098">
        <property type="protein sequence ID" value="QAS62098"/>
        <property type="gene ID" value="EI377_15950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="90" mass="10509" checksum="0337A1200C8105F7" modified="2018-12-05" version="1">MYAFKDIIVLDEPTAAIDPLEESRVFNKFKELANGRTAIIVTHRMGTVKIADRIIVMEDGCIKECGSHDELMNYDRSYKNMYLSQEKWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX7</accession>
    <name>A0A386PEX7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliJ</name>
        <name evidence="12" type="ORF">CP523_02595</name>
        <name evidence="13" type="ORF">EI377_13130</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00448"/>
    <dbReference type="EnsemblBacteria" id="AYE33428">
        <property type="protein sequence ID" value="AYE33428"/>
        <property type="gene ID" value="CP523_02595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61602">
        <property type="protein sequence ID" value="QAS61602"/>
        <property type="gene ID" value="EI377_13130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="17858" checksum="AEADA3FA8BABE23B" modified="2018-12-05" version="1">MAKRFEFGLEKLLQIRVEKEDENKRLFTESQREREIVKEKLKSLKESYSKYNGIGSGDSAAYQKIKKNYLFALNKGIDSTEKEVALKEREVNFRRENLKKSQIERKTVDILKEKQKIAYIREQDRIEQISNDEFALYAYMRNHRKEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF23</accession>
    <name>A0A386PF23_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04825</name>
        <name evidence="2" type="ORF">EI377_15335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675778.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33844">
        <property type="protein sequence ID" value="AYE33844"/>
        <property type="gene ID" value="CP523_04825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61990">
        <property type="protein sequence ID" value="QAS61990"/>
        <property type="gene ID" value="EI377_15335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="21564" checksum="EFC691F9C174EA46" modified="2018-12-05" version="1">MRLEDFKDIEEDFQITFKERLRDYMRIFNLGDDHRIIAMHMGGVFLECLLKHKIISMYELKKCKYVKKNEVWFSDEAVREIVTEDKPTEQYIKSRGIINPGHNLINAIKLLRDLDESLNSYDMELVNNPLINDSKEYKSFIDLEYCTIKDFRNLENTFDSWIKSFNNLKSIIVAYKGWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF49</accession>
    <name>A0A386PF49_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675399.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33651">
        <property type="protein sequence ID" value="AYE33651"/>
        <property type="gene ID" value="CP523_03790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="91" mass="10928" checksum="BDF53AF37830B580" modified="2018-12-05" version="1">MKLVKVVFDSYEKGRITRVCVPFDYGPSRRYRDGENRYHFYDLDSPLSNHNLSILPQQIKSIEILNETFCPEDYVKWTPSWFLSRDWGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA2</accession>
    <name>A0A386PFA2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoD</name>
        <name evidence="6" type="synonym">sigA</name>
        <name evidence="10" type="ORF">CP523_02150</name>
        <name evidence="11" type="ORF">EI377_12670</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674060.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00537"/>
    <dbReference type="EnsemblBacteria" id="AYE33346">
        <property type="protein sequence ID" value="AYE33346"/>
        <property type="gene ID" value="CP523_02150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61516">
        <property type="protein sequence ID" value="QAS61516"/>
        <property type="gene ID" value="EI377_12670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="136"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="215"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="304"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="369" mass="42243" checksum="0B14EA6E368A4AE8" modified="2018-12-05" version="1">MVDQKTKAKQGKKNNEDKNSKMAVVKNLLDKGKKTGTLTYKQIMDEIEHIELGPEQIEKIYEVLESMGIEVLGEINSVEEVEEEEIDLSVPEGIAIDDPVRMYLKEIGKVPLLSSEDEIELALRIEEGDQYAKKKLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNLGLIKAVEKFDYRKGFKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVQRQLLQELGRDPFPEEISKVMDLPVDKVREIQKIAQEPVSLETPIGEEEDSHLGDFIPDDDAPAPAEAAAFTMLKEQLINVLDTLTPREEKVLRLRFGLDDGRARTLEEVGKEFNVTRERIRQIEAKALRKLRHPSRSKKLKDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB1</accession>
    <name>A0A386PFB1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS sugar transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05250</name>
        <name evidence="3" type="ORF">EI377_15810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676259.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01839"/>
    <dbReference type="EnsemblBacteria" id="AYE33924">
        <property type="protein sequence ID" value="AYE33924"/>
        <property type="gene ID" value="CP523_05250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62075">
        <property type="protein sequence ID" value="QAS62075"/>
        <property type="gene ID" value="EI377_15810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="16610" checksum="27BD52B802A8B61F" modified="2018-12-05" version="1">MFNELLEKNRYSFHEGFDNWEDAVKAACQPLIKEGAILPSYVDSIIRCVNEYGPYIVIAPNICIPHAQEGTDGDVKTTSICFMKTEKPVHFSEDPEHDARLFFVLASENSELHLQNLTELVGLISDEEVVEKLLNAKSVEDLKRIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC3</accession>
    <name>A0A386PFC3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_06450</name>
        <name evidence="6" type="ORF">EI377_00930</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677431.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02167"/>
    <dbReference type="EnsemblBacteria" id="AYE34137">
        <property type="protein sequence ID" value="AYE34137"/>
        <property type="gene ID" value="CP523_06450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59505">
        <property type="protein sequence ID" value="QAS59505"/>
        <property type="gene ID" value="EI377_00930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="6"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="112"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="332" mass="36560" checksum="23BB33AFC95CED5E" modified="2018-12-05" version="1">MSIKLVCYGVRDTEVPFFHKLNKYGYQLVLVNKNLDHENVKEALGAEAIMVRGNCKADRQNLELLKLHGLKTVLTRTVGFDHVDLEATKDLDLKVARVPGYSPNAISELAVTLAMMLVRNTAYTTNRTKDKNFVVDSQMFSKEIRNCTVGVLALGRIGLTTAKLFKGLGANVIGYDVFQSDVAKEVVEFKSLDEVLAESDVIAVHTPYIKGQNYHMIDDEFIAKMKDGAILINTARGEVQDLDAITRALESGKLGGFGTDVIEGESGIFFNNLTGQTINNASVEKLIGMYPKALVTPHMGSYTDEALRNMISISYDNLNDIIETGNSKNEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD6</accession>
    <name>A0A386PFD6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04205</name>
        <name evidence="6" type="ORF">EI377_14730</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676513.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00435"/>
    <dbReference type="EnsemblBacteria" id="AYE33731">
        <property type="protein sequence ID" value="AYE33731"/>
        <property type="gene ID" value="CP523_04205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61888">
        <property type="protein sequence ID" value="QAS61888"/>
        <property type="gene ID" value="EI377_14730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="313"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="514"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="599" mass="67142" checksum="DEECD4242F084300" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG3</accession>
    <name>A0A386PFG3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05625</name>
        <name evidence="2" type="ORF">EI377_00055</name>
        <name evidence="3" type="ORF">EI377_16140</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33984">
        <property type="protein sequence ID" value="AYE33984"/>
        <property type="gene ID" value="CP523_05625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59347">
        <property type="protein sequence ID" value="QAS59347"/>
        <property type="gene ID" value="EI377_00055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62126">
        <property type="protein sequence ID" value="QAS62126"/>
        <property type="gene ID" value="EI377_16140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="8882" checksum="63208E150D57E3D5" modified="2018-12-05" version="1">MTIVELEKELNKIGVPKELYSLMIGGFPNEKLCIVKEESWQVYYSERGHKSGLNVFDTEADACEFFLRKMKRYSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK9</accession>
    <name>A0A386PFK9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02740</name>
        <name evidence="4" type="ORF">EI377_13265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676961.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00954"/>
    <dbReference type="EnsemblBacteria" id="AYE33456">
        <property type="protein sequence ID" value="AYE33456"/>
        <property type="gene ID" value="CP523_02740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61627">
        <property type="protein sequence ID" value="QAS61627"/>
        <property type="gene ID" value="EI377_13265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="198" mass="21389" checksum="79A1784F1F8451CD" modified="2018-12-05" version="1">MNYKELTKIQLDALKEISNIGAGNSATSLSILLGSKIDMSVPNVNIIAFEDLFDQHKENEVVAVLVKVLDDIEGSLLYVFETEIALNIISSLCGYKNQIDDMGISVIGEVGNIIASSFMNAISDFINIRATVSVPAVANDMLSAVLVSTFIEAGQYDEYALDIETLYTGENNSNIQGNLYYIPAPGSLEKILKSIGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL6</accession>
    <name>A0A386PFL6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01965</name>
        <name evidence="3" type="ORF">EI377_12485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678260.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01155"/>
    <dbReference type="EnsemblBacteria" id="AYE33312">
        <property type="protein sequence ID" value="AYE33312"/>
        <property type="gene ID" value="CP523_01965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61482">
        <property type="protein sequence ID" value="QAS61482"/>
        <property type="gene ID" value="EI377_12485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="33664" checksum="5558579F03AF7922" modified="2018-12-05" version="1">MIIRENIVEVSDISEEFILKTDKINRRQDELIFFDLEHYVYKKPKCIGVFGACIFNNDDKKLHVTQYMIENKSEVVDILILARRYFIDMKKHGKNSIVTFSGNNDFTVINYLFKKYNIQYDFSKEFQDIDIQREYERVYGHSIGLKNLEKVFEIFREGELISGSNLAKTFHKVLKDREYILRMPKKKVENILLYNEQDVTNLYNIFTLWNKFIIETTEIKDDEEETKIDKENDNDKLVDNVNEKYDTKEEKIVDDIYIKNKEVSGLEEKDNIQLKELVNEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS2</accession>
    <name>A0A386PFS2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_00420</name>
        <name evidence="9" type="ORF">EI377_10910</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678158.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00595"/>
    <dbReference type="EnsemblBacteria" id="AYE33019">
        <property type="protein sequence ID" value="AYE33019"/>
        <property type="gene ID" value="CP523_00420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61188">
        <property type="protein sequence ID" value="QAS61188"/>
        <property type="gene ID" value="EI377_10910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="23842" checksum="117A34400801633F" modified="2018-12-05" version="1">MQVKIKDLSFKYDNSKDMIIDKFSLNIEKGEIVAILGASGCGKSTILRLIAGLEEPYSGEIILGNKIVVTDEKFVSPEDREVGMVFQDYALFPHLNVYENIKFGLHKISKKEQKEIVENMIKLVNLEGYENRYPYELSGGQQQRVALARALAPKPVIILMDEPFSNLDSHLRGKIREELKEIIKKSKTTCIFVTHDIEDVKAISDRVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS8</accession>
    <name>A0A386PFS8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_04965</name>
        <name evidence="11" type="ORF">EI377_15465</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675721.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01684"/>
    <dbReference type="EnsemblBacteria" id="AYE33871">
        <property type="protein sequence ID" value="AYE33871"/>
        <property type="gene ID" value="CP523_04965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62013">
        <property type="protein sequence ID" value="QAS62013"/>
        <property type="gene ID" value="EI377_15465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS62013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="23861" checksum="1817E266B2CF2DE0" modified="2018-12-05" version="1">MLIVENKPRSVAAESYRTLRTNIQYSSFDEECKSIVITSSEPGEGKSTTAANLALSLAQGEKKVILIDCDLRKPSIHKKFKISNLTGLSDVLIGQKKLIQVLKRHGDNLLLLTSGKIPPNPSEMLGSKAMKNLLKELRENFDYIIIDTPPVQAVTDSQVLSTEADGTLLVIKAEKTKRDSVHNSINLLRKVNANIIGTVLNGVNNNSENYHYYGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT2</accession>
    <name>A0A386PFT2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome C551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11050</name>
        <name evidence="3" type="ORF">EI377_05840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677102.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00930"/>
    <dbReference type="EnsemblBacteria" id="AYE34903">
        <property type="protein sequence ID" value="AYE34903"/>
        <property type="gene ID" value="CP523_11050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60297">
        <property type="protein sequence ID" value="QAS60297"/>
        <property type="gene ID" value="EI377_05840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="51" mass="6114" checksum="00D975219EF1C3ED" modified="2018-12-05" version="1">MEDKKIICKDCGKEFLFTVGEQEFYKEKGFDNDPVRCPDCRRARKAQNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW6</accession>
    <name>A0A386PFW6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF448 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">YlxR family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00680</name>
        <name evidence="3" type="ORF">EI377_11170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676382.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00667"/>
    <dbReference type="EnsemblBacteria" id="AYE33069">
        <property type="protein sequence ID" value="AYE33069"/>
        <property type="gene ID" value="CP523_00680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61238">
        <property type="protein sequence ID" value="QAS61238"/>
        <property type="gene ID" value="EI377_11170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="88" mass="9976" checksum="A073DB48FE645E8F" modified="2018-12-05" version="1">MKVKKIPLRMCTGCMEMKPKKELIRVVKSPDGDVSVDLTGKKSGRGAYICKNSACLEKAFKAKRLSRNLDVTIDEAIYRKLKEEIENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX1</accession>
    <name>A0A386PFX1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4317 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04520</name>
        <name evidence="3" type="ORF">EI377_15080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00374"/>
    <dbReference type="EnsemblBacteria" id="AYE33788">
        <property type="protein sequence ID" value="AYE33788"/>
        <property type="gene ID" value="CP523_04520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61946">
        <property type="protein sequence ID" value="QAS61946"/>
        <property type="gene ID" value="EI377_15080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025466">
        <property type="entry name" value="DUF4317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14199">
        <property type="entry name" value="DUF4317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="460" mass="52989" checksum="E3F74CFE9B42DD7E" modified="2018-12-05" version="1">MMKKDILELKKRLKKDYCTFTKMCGCYVNGEKHTILKFRETFLNLDEDEYFKYLEIAKKVLSGTIGNNILELNFPLNDDLINEKQLFLMQLKNSQLKDDSILDNFYESIINNYDYTGNFLILIFHDAYDVITKTKDNLKLDESEEVYEYMLCAICPVSLSEPGLRYFEEENKIKARIRDWVVEAPINGFVFPAFINRSSDVNSIMYYTKNAKDTHPELMENTLGCSSRQTVTIQKETFQSIIKDSMGADEKKADKIFMEVQENLNNMIEEYNSIYNDTDAEPIALTKDNIQELLIDSGVPEEITNKIEKSYLENFGEDLPLVESLIDAKVLKANAQRKKEESLIKQVEILQTKLNEVKQESAITNETTDGNNNILEETLKADLEENLETNLENSLEESLEKTNDTDLENNNTTNDYDVILHVKPEKVPQIKSQIIDGQKCIVVPINENELATVNGLEDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG37</accession>
    <name>A0A386PG37_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08200</name>
        <name evidence="3" type="ORF">EI377_02950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674695.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34407">
        <property type="protein sequence ID" value="AYE34407"/>
        <property type="gene ID" value="CP523_08200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59812">
        <property type="protein sequence ID" value="QAS59812"/>
        <property type="gene ID" value="EI377_02950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="16316" checksum="50601468A71E4B01" modified="2018-12-05" version="1">MECKNEAIGKYISEIYRNSCRFFSKEFLKLNLGVGQYIFLIQLYKRDGINQEELSELLKIDKANTARAIKRLEEEGYVIRIRCKEDKRAYNVFLTDKALDIKEEFFGILQSWENNITQPLTEEEIIIVKKILKKITVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG48</accession>
    <name>A0A386PG48_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="4" type="ORF">CP523_10300</name>
        <name evidence="5" type="ORF">EI377_05080</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674291.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01435"/>
    <dbReference type="EnsemblBacteria" id="AYE34760">
        <property type="protein sequence ID" value="AYE34760"/>
        <property type="gene ID" value="CP523_10300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60160">
        <property type="protein sequence ID" value="QAS60160"/>
        <property type="gene ID" value="EI377_05080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="113"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="174" mass="20255" checksum="FC543EC410EE0064" modified="2018-12-05" version="1">MKVTVITRNTKLTPALKDMVERKISKMDRYFEPNVAAKATLTVQKNRHIVEVTIPFNGVILRAEEATDDMYKSIDLVEEKLERQIRKQRTKLARRNNESLRFSHIDEVATEEDDGKLVKTKKFGLKPMSSDEAVLQMELLGHNFFVYQDADKNKLCVMYKRKDGNYGLLEPEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGK3</accession>
    <name>A0A386PGK3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS110 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679076.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33998">
        <property type="protein sequence ID" value="AYE33998"/>
        <property type="gene ID" value="CP523_05710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="409" mass="46751" checksum="CFC3C1A8ADD51C34" modified="2018-12-05" version="1">MHKKQNHIYVGLDLHKDTHTAVIIDCWDEKIDSITIENKPSDFTKLMNKVKKHAGKLTPVYGLEDVHGYGRSLAVFLIERGMIVKEVNSALSFMERMSYPTTKKSDDWDAKCIASVLLRKLDTLPDANPQDLYWTIKMMVNRRDAIVKSVTTLTNQLHESLNYNYPSYKKFFSDVNSKTALAFYEKYPSPKHLQGVTDETLGEFLRKPSHNSCSTRKAKEILDIVESDGDTTREYQESRDFIIQSIVRDITFKSEEIKKVEVEMKKLLKLLDLKLETIPGVDTITAIALVAHIGDIKRFRNADKLAKFSGIAPVNFSSAGKGKDKKSKQGNRGLYGVFYFLAVQQIQVSKKGTPRNPVFLEYYKRKVSEGKTKIQALVCVMRRLNNIIYGMMKNKTEYVMPNVEIKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN9</accession>
    <name>A0A386PGN9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">carB</name>
        <name evidence="17" type="ORF">CP523_08070</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00729"/>
    <dbReference type="EnsemblBacteria" id="AYE34384">
        <property type="protein sequence ID" value="AYE34384"/>
        <property type="gene ID" value="CP523_08070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08070"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="674"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="932"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate synthetic domain" evidence="13">
        <location>
            <begin position="550"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="933"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="823"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE34384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119224" checksum="C78F56DFFE0E9D7A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP6</accession>
    <name>A0A386PGP6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04105</name>
        <name evidence="2" type="ORF">EI377_14625</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676890.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33712">
        <property type="protein sequence ID" value="AYE33712"/>
        <property type="gene ID" value="CP523_04105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61867">
        <property type="protein sequence ID" value="QAS61867"/>
        <property type="gene ID" value="EI377_14625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="288" mass="33722" checksum="4BDF50D90934669D" modified="2018-12-05" version="1">MFISMPKDFFIPVLFSDNFELDSETGQMEYDTNTREKININENMSRGEGAETYQKKYAENVIKEKVNTSLQPEKEEFKKVQNEELIDIHINVIEKAIINNINIKQNLCNLNKVSINGKNFEDNLDEHLDRIEDIIKQHIQKYAYVNKSAVGTEFTNGEKAKLKDKLINITKDNFAFLNEITSNMEPAEELNVILIYLKVILMYHINNMGCPNKYNGNNIEELIEMHLDKIKSNFCNNCKLLMCNRISDDENYEDDKEVDLKEMQKKILYKDNLISEIDNEYIYSVITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV9</accession>
    <name>A0A386PGV9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04890</name>
        <name evidence="2" type="ORF">EI377_15400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33856">
        <property type="protein sequence ID" value="AYE33856"/>
        <property type="gene ID" value="CP523_04890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62001">
        <property type="protein sequence ID" value="QAS62001"/>
        <property type="gene ID" value="EI377_15400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="150" mass="17464" checksum="3B1EBF94E986FBAF" modified="2018-12-05" version="1">MKKIYILSIVILMFILYGCSSKTLNISDLEPSNIVVDYDTINATVKEDPIKSSKENITLVLKNKTKYEYFYGVDFELEVELDDNWYKIPFHKNPEFIEISMILNGNSESNEEIELSKYFSDLPDGKYRILKTFYLDDSKTVVSGLFNIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX0</accession>
    <name>A0A386PGX0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13300</name>
        <name evidence="3" type="ORF">EI377_08170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677493.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35323">
        <property type="protein sequence ID" value="AYE35323"/>
        <property type="gene ID" value="CP523_13300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60713">
        <property type="protein sequence ID" value="QAS60713"/>
        <property type="gene ID" value="EI377_08170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019715">
        <property type="entry name" value="Haemolysin_XhlA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10779">
        <property type="entry name" value="XhlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="77" mass="8886" checksum="7F09D9833F7D7753" modified="2018-12-05" version="1">MNDELINHQLKIHEKRINNHSERLDELEQGRAATDVKIDNLCEKLGAQTKSINWLIGLMVSSLLGFFFYAIQKGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH45</accession>
    <name>A0A386PH45_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">asnA</name>
        <name evidence="5" type="ORF">CP523_12170</name>
        <name evidence="6" type="ORF">EI377_06990</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673556.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02989"/>
    <dbReference type="EnsemblBacteria" id="AYE35110">
        <property type="protein sequence ID" value="AYE35110"/>
        <property type="gene ID" value="CP523_12170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60501">
        <property type="protein sequence ID" value="QAS60501"/>
        <property type="gene ID" value="EI377_06990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12170"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00645">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="26"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="338" mass="39053" checksum="5022F76E67FFDCEF" modified="2018-12-05" version="1">MCKERLILPKGYKPHLSLRETEIAIKAVKDFFESELSKALNLTRVSAPLFVERNTGLNDALNGTERPVSFDMRGIDGSSFEIVHSLAKWKRMALYRYGFSPNEGLYTDMNAIRRDEDLDNTHSTYVDQWDWERIITKEQRTEETLRSIVKTIYEVFKKTEKFLSSKYEYFDEILPEDIYFITAQELEDKYPTLTSKEREDAICREKKAVFIQGIGGALASGEKHDGRSPDYDDWSLNGDILFYYPVFDKALELSSMGIRVDETALLNQLKVSGCEDRKELDFHKKLLQGKLPYTVGGGIGQSRICMFFLRKAHVGEVQASVWPEEMIEICEEHNIHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH47</accession>
    <name>A0A386PH47_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13725</name>
        <name evidence="4" type="ORF">EI377_08615</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677159.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02077"/>
    <dbReference type="EnsemblBacteria" id="AYE35403">
        <property type="protein sequence ID" value="AYE35403"/>
        <property type="gene ID" value="CP523_13725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60791">
        <property type="protein sequence ID" value="QAS60791"/>
        <property type="gene ID" value="EI377_08615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="24425" checksum="A96C79E57C1B714C" modified="2018-12-05" version="1">MKKIDFKGSVVLNPVPVVLITSRSLEGKDNVFTVGWTGTVCTKPPMLSISIRPERLSYEYIKDTMEFIVNIPSAKMVKAVDFCGVKPGKKIDKIKEMGFTMKEGTNVNVAYIDECPITIECKVIQIIKLGTHDMFIAEVLASHINDSLIDEKGKIHFEKGDLISYCHGEYFKLPQNSIGSFGFSVAKKKNVSNTKNNKRKSSNISNKKKYATKKTKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH49</accession>
    <name>A0A386PH49_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase (Non-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05080</name>
        <name evidence="4" type="ORF">EI377_15640</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01806"/>
    <dbReference type="EnsemblBacteria" id="AYE33892">
        <property type="protein sequence ID" value="AYE33892"/>
        <property type="gene ID" value="CP523_05080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62043">
        <property type="protein sequence ID" value="QAS62043"/>
        <property type="gene ID" value="EI377_15640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="386" mass="43628" checksum="84820D749C964B89" modified="2018-12-05" version="1">MKKIKVMSIFGTRPEAIKMAPLVKELDKSENIDSLVCVTAQHREMLDQVLELFDINPDYDMDIMKEKQTLTGITNRVLQGLEDIFEESKPDMILVHGDTTTTFAGALAAFYKKIKVGHVEAGLRTGDKYFPFPEEMNRKLTGAMADLHFAPTNGSKKNLLREGISESDIIVTGNTVIDAMEFTVEENYVFDNKELNNIDFKNKKVIMVTAHRRENWGEGIENICTSLKKIVEENNDVELIYLVHLNPVVKDVVEKHLKGMDRVHLLSPLDTKETHNLMNKCFMVMTDSGGLQEEAPHLGKPVLVLRDVTERPEAVEAGTVKLVGTDKNTIINEANLLIRDSKAYELMSRSVNPYGDGEASRRIVQAIEKYFGRNNENVDEFNLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH56</accession>
    <name>A0A386PH56_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dabb family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Stress responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03025</name>
        <name evidence="3" type="ORF">EI377_13525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678437.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01772"/>
    <dbReference type="EnsemblBacteria" id="AYE33509">
        <property type="protein sequence ID" value="AYE33509"/>
        <property type="gene ID" value="CP523_03025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61675">
        <property type="protein sequence ID" value="QAS61675"/>
        <property type="gene ID" value="EI377_13525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="100" mass="11596" checksum="22233554A0FC5C04" modified="2018-12-05" version="1">MIKHIVMWKLKDNAEGENKITNANKIKKLIEDLKELISEIKFIEVGINIKEGSQAYDIVLNSEFSSLEDLDSYQKNKKHLEVAKFISKVSEERAVVDYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH73</accession>
    <name>A0A386PH73_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_07105</name>
        <name evidence="13" type="ORF">EI377_01850</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673707.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01036"/>
    <dbReference type="EnsemblBacteria" id="AYE34238">
        <property type="protein sequence ID" value="AYE34238"/>
        <property type="gene ID" value="CP523_07105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59643">
        <property type="protein sequence ID" value="QAS59643"/>
        <property type="gene ID" value="EI377_01850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
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    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
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        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="325"/>
            <end position="509"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="509" mass="57043" checksum="AFAA36C288F462F6" modified="2018-12-05" version="1">MKLKRKIRILTLTILLGIIGLLSIVSIKYIKEEIKKQTINRLRDTSALIASVPLIQDNLNKQNGSIVIQNYTEKLRLKTGLLFITVIDMEGRRYSHPLKEYIGLRFSGGDEAAVLSYGGSYISESIGHLGKSIRAFSPIYKDGEQVGAVCVGMLSGDLKNEVISFLSKMMPIFITTVILAVIGATLLSINIKKSILGLEPKEIALLLKEKESIINNINDGLIAVNDIGQINLINDRAKEILKINNDDVYYRITDLLMETLMDKKAMHNVEIRIPNGIRIMSNFTAILNKEGKTLGAIVTFQDLTKVSQMAEELTGIRELTWDLRAQNHEFLNKLHTIAGLIQLEESDKALEYIFDTTEVRSEIAQIIGKIENPTLQGIIFAKYNSAQEAKIKFELSSNSYMKSIPNNIKVQDMVSILGNLLENSIEELKGKKDGWIFLEIRQEENLKIVVKNNGAKIPDDMKENIFKRGFSTKEGERGLGLYSINEIIEASGGKLTLKSQSITEWIVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH76</accession>
    <name>A0A386PH76_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05435</name>
        <name evidence="2" type="ORF">EI377_15995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02581"/>
    <dbReference type="EnsemblBacteria" id="AYE33956">
        <property type="protein sequence ID" value="AYE33956"/>
        <property type="gene ID" value="CP523_05435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62107">
        <property type="protein sequence ID" value="QAS62107"/>
        <property type="gene ID" value="EI377_15995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="795" mass="92377" checksum="D833EA6D45756147" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH83</accession>
    <name>A0A386PH83_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_07170</name>
        <name evidence="9" type="ORF">EI377_01925</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673721.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01049"/>
    <dbReference type="EnsemblBacteria" id="AYE34248">
        <property type="protein sequence ID" value="AYE34248"/>
        <property type="gene ID" value="CP523_07170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59654">
        <property type="protein sequence ID" value="QAS59654"/>
        <property type="gene ID" value="EI377_01925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="7">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="114"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Fer4_20" evidence="7">
        <location>
            <begin position="469"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="5">
        <location>
            <begin position="606"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="5">
        <location>
            <begin position="724"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="858" mass="96740" checksum="3276C8682AA6FCF1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH89</accession>
    <name>A0A386PH89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetaldehyde dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12425</name>
        <name evidence="5" type="ORF">EI377_07310</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675338.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02028"/>
    <dbReference type="EnsemblBacteria" id="AYE35160">
        <property type="protein sequence ID" value="AYE35160"/>
        <property type="gene ID" value="CP523_12425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60563">
        <property type="protein sequence ID" value="QAS60563"/>
        <property type="gene ID" value="EI377_07310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="12"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="497" mass="55002" checksum="0CCC7744E8282B5B" modified="2018-12-05" version="1">MNIIDNDLLSMQEARILVENAREAQKKLATFPQEKLDEIVERMVEEVEKHLKEFAQMSNEETEYGRWEDKYIKNSFVCKYLRDRLQGMKCVGIINKDKENNTMDVGVPMGVIIAFCPATSPISTTIYKALIAIKSGNAIIFSPHPRAKNTISKTVDILIRAAQGVGLPEGALAYLHTVMASGSLELMNHKDTSLIMNTGVPEMLDAAYKSGKPVIYGGNGNGPAFIERTADIEQAVKDIISSKNFDYGVVSAAEQSIVVDSCIVAEVKKALQKNGGYFMTQEESEKLGDIFFYKDGSPNLEVIGKCPQFLAKKAGFTVSDDVKVLISEQKFVSNSNPYSREKLCPVLAFYIEDDWMHACEKCIELLLSERQGHTLVIHSRDEDVIQQFALKKPVGRVLVNTSGTFGSMGATTNLFPSMTLGSGSAGEGMTSDNVSPMNLIYVRKIGYGVRKVDEMLKLLEPKDNSSYTVLENSVSKNEIDNVKLLESILKKILSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF8</accession>
    <name>A0A386PHF8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOL1/NOP2/sun family RNA methylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">RsmB/NOP family class I SAM-dependent RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14325</name>
        <name evidence="8" type="ORF">EI377_09235</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676782.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02455"/>
    <dbReference type="EnsemblBacteria" id="AYE35513">
        <property type="protein sequence ID" value="AYE35513"/>
        <property type="gene ID" value="CP523_14325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60898">
        <property type="protein sequence ID" value="QAS60898"/>
        <property type="gene ID" value="EI377_09235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="320" mass="37186" checksum="3F8132F0C3074304" modified="2018-12-05" version="1">MSIKEIQYRLPDDFIKILEKIFTRCQLDTIYKSYENGRSTTFRVNKLKGNTKEVMDELSSHRIKAVNYSKLNNTFIIKGSKESSLKKLKIYNEGKIYLQNISSMLPPLFLDVKEGQTILDMCAAPGGKSLLMADMTSNKATIFANDINEIRRERLNYNAEKQGAESIIILGTDGRTIGKRLNDYFDRILLDAPCSGEGIIHIRNFRKFNGWTEKRVRNCVKLQKQLIESAYNALKENGVMIYSTCTLNPFENEEIVEYILNKHKDLKLEKINLDLPNVIRGITRYEDKFYRKDLKNSIRIIPNEIFEGFFIAKFRKINSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH0</accession>
    <name>A0A386PHH0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34511">
        <property type="protein sequence ID" value="AYE34511"/>
        <property type="gene ID" value="CP523_08815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="82" mass="9353" checksum="D62F876406291230" modified="2018-12-05" version="1">MSRPVINLFLNKKEKFGKNNLIKSKGDDILINKNLFSNITSKNILKENTQKNLSENLSSIYVQNSLDNMVLNSNLDNNNVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH4</accession>
    <name>A0A386PHH4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chemotaxis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03675</name>
        <name evidence="7" type="ORF">EI377_14205</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677703.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02210"/>
    <dbReference type="EnsemblBacteria" id="AYE33629">
        <property type="protein sequence ID" value="AYE33629"/>
        <property type="gene ID" value="CP523_03675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61793">
        <property type="protein sequence ID" value="QAS61793"/>
        <property type="gene ID" value="EI377_14205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="278"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="564" mass="62519" checksum="AA655567613EE0D3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI9</accession>
    <name>A0A386PHI9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10770</name>
        <name evidence="2" type="ORF">EI377_05555</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674096.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01348"/>
    <dbReference type="EnsemblBacteria" id="AYE34847">
        <property type="protein sequence ID" value="AYE34847"/>
        <property type="gene ID" value="CP523_10770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60241">
        <property type="protein sequence ID" value="QAS60241"/>
        <property type="gene ID" value="EI377_05555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="312" mass="34114" checksum="BDD071080805BCF5" modified="2018-12-05" version="1">MKYLGVDIGGTSVKIGLVTDRGKIIAEDNFSVSFDNYETPIFETVKKSIDEFLNNNDIDSRELSGIGVSATGQVNTTTGTIVGVGGNIKNWCDTEIKKELEEIYKLKTTVINDANSMVIGEQWIGRAKGYKNIIGITIGTGIGGGIIVNSNILLGNIGIAGELGHFSINSNGKQCTCGNIGCYEQYGSMTALIKEVKERYEDIENLSFEKDKVNGKNIFDELEKGNKKLEIIVNNWIENIGKGLVSLTHIFNPEIIIIGGAVSKQEKLFIDPVREYVLTNVMKKFGENLRVEAAKLENNAGLVGAVYYNINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN0</accession>
    <name>A0A386PHN0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="6" type="ORF">CP523_09125</name>
        <name evidence="7" type="ORF">EI377_03870</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678383.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00263"/>
    <dbReference type="EnsemblBacteria" id="AYE34571">
        <property type="protein sequence ID" value="AYE34571"/>
        <property type="gene ID" value="CP523_09125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59971">
        <property type="protein sequence ID" value="QAS59971"/>
        <property type="gene ID" value="EI377_03870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="113" mass="12909" checksum="8AD7FBBC7A3653BC" modified="2018-12-05" version="1">MAGYRKLGLATDQRRAMLRSLVTSFLKHGKIETTETRAKETRKLAEKMITLAKRGDLHARRQVLSYVLEEEVVQNLFDNVAPKYAERNGGYTRMYKKGPRRGDGAEVVILELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS9</accession>
    <name>A0A386PHS9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09380</name>
        <name evidence="7" type="ORF">EI377_04125</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678032.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02734"/>
    <dbReference type="EnsemblBacteria" id="AYE34621">
        <property type="protein sequence ID" value="AYE34621"/>
        <property type="gene ID" value="CP523_09380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60021">
        <property type="protein sequence ID" value="QAS60021"/>
        <property type="gene ID" value="EI377_04125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="24328" checksum="CB0FFAE3A6DFBA94" modified="2018-12-05" version="1">MSYQSVAKKNYLAILSTFFIALVFLGIGSFIGVKFIPPSVRSFMNMAFFIVVLFSLFSKKGGFIRSKKSMYIYALVLGILTGSTYIYYFNTLGAGTFISIVLGVVLIFGMAYIVASRANEGDLFKLGPIIFGGIIILLILEFINIFLFKFGTFDIILSSVGIIIYSMYSIIIMKSVQVRCRYGVLSEIEVVSLAYSIFISFLNLLLDILRLVSILKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT8</accession>
    <name>A0A386PHT8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">atpD</name>
        <name evidence="12" type="ORF">CP523_10190</name>
        <name evidence="13" type="ORF">EI377_05005</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676645.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00367"/>
    <dbReference type="EnsemblBacteria" id="AYE34744">
        <property type="protein sequence ID" value="AYE34744"/>
        <property type="gene ID" value="CP523_10190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60146">
        <property type="protein sequence ID" value="QAS60146"/>
        <property type="gene ID" value="EI377_05005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="144"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="152"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="50561" checksum="9D03409F6F1BA039" modified="2018-12-05" version="1">MPKKVGKVVQVIGPVVDIKFDSDALPNIYNEIRIDMEDKVLVAEVEQHIGDDIVRTIAMESTDGLKRGMKATDTGKCISVPVGKGVLGRLFNVLGNPIDNAGDIEMEEVYPIHRPAPSFKEQALEPEMFETGIKVIDLLAPYQKGGKIGLFGGAGVGKTVLIQELINNIAKEHGGLSVFTGVGERSREGNDLYYEMKESGVIDKTALVFGQMNESPGARMRVSLTGLTMAEYFRDQGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGALQERITSTKNGSITSVQAVYVPADDLTDPAPATTFTHLDATTVLARSIAELGIYPAVDPLESSSRILDPRVVGKEHYQVATDVKNILERYKELQDIIAILGVDELSDEDKSVVARARRVQRFLSQPFTVAEQFTGMQGKYVPVKETVRGFKEILEGKYDDLPESAFLFVGSVEEAVEKAKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV0</accession>
    <name>A0A386PHV0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08460</name>
        <name evidence="6" type="ORF">EI377_03205</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674822.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01633"/>
    <dbReference type="EnsemblBacteria" id="AYE34458">
        <property type="protein sequence ID" value="AYE34458"/>
        <property type="gene ID" value="CP523_08460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59861">
        <property type="protein sequence ID" value="QAS59861"/>
        <property type="gene ID" value="EI377_03205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26565" checksum="D5EE8CB7003A33BB" modified="2018-12-05" version="1">MRIAAISDIHGNIYALMKTLEDIDEQKVDMIVCLGDLVGYGPHPNEVIALIRRRNLPCIKGNYDASVVDGAFSYIRDTEINSFSLPWNCQEVRESNKFYLNQLPEFLEYKVDDLKIKFVHGSPNKINEYLFADAENTQKIMEDLKEDVLVCAHTHIPIIKEFNNKLFINVGSVGKPKIGRPNITYCILDIENNTVKSRIRELEYEYKRIVKDTQLLSFPCNLINSYISGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY9</accession>
    <name>A0A386PHY9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09910</name>
        <name evidence="2" type="ORF">EI377_04695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676527.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00311"/>
    <dbReference type="EnsemblBacteria" id="AYE34691">
        <property type="protein sequence ID" value="AYE34691"/>
        <property type="gene ID" value="CP523_09910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60092">
        <property type="protein sequence ID" value="QAS60092"/>
        <property type="gene ID" value="EI377_04695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="495" mass="56585" checksum="A8283FA95BD2DB7B" modified="2018-12-05" version="1">MKKFIYFINIFVVLFLLSGCHKIGGKDIATTKTPKNNLLSIKGSWKVDSVEIVDENLNIASVDNDITDSEINISDSAIEIKDVKYDRPKYKLKVVDKNYMLSYEAGLKVSSFINNDDKIDVISIINKNNTLIGEFIIKEKDRGFLFYRGMILELSRISENVEDKDYPLENKNNYSDESAANDYNSEVGVMLGLKVPRKKNEDGGYTKEKYRTLWISFKDGELQPIMEKENIIFPRMTGIWALKSNTANYNGNEIEYFNVSPIDGKDVEVNSEIKDKNVYKNIKFVGNNYIAIEKYEGNDFQNKFPIYQVIPIDNINAENGIIIEEIYSKDASEKYKIAYENELSKLSAESKAKLNTNIDYSNFSIERKEGKWKLVGKISPVDLNSNGLDYAIGLNPNKKLLNYDALTVPWKVLKGELPLIRDAYIAPTERIAIIVFEDNIAVYEVDNRRLKGSPLVNIKLNGEEEVIMAEWSSQGYVKSWSNVFSDGRNVMEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM5</accession>
    <name>A0A386PIM5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsH</name>
        <name evidence="10" type="ORF">CP523_11630</name>
        <name evidence="11" type="ORF">EI377_06445</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02884"/>
    <dbReference type="EnsemblBacteria" id="AYE35014">
        <property type="protein sequence ID" value="AYE35014"/>
        <property type="gene ID" value="CP523_11630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60407">
        <property type="protein sequence ID" value="QAS60407"/>
        <property type="gene ID" value="EI377_06445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="182"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="581" mass="63890" checksum="6FD16546CEF08849" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN7</accession>
    <name>A0A386PIN7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">CP523_12945</name>
        <name evidence="21" type="ORF">EI377_07825</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="21 23" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 23">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678213.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03023"/>
    <dbReference type="EnsemblBacteria" id="AYE35257">
        <property type="protein sequence ID" value="AYE35257"/>
        <property type="gene ID" value="CP523_12945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60652">
        <property type="protein sequence ID" value="QAS60652"/>
        <property type="gene ID" value="EI377_07825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12945"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AYE35257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QAS60652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="27844" checksum="B5E93B8C2BE3229B" modified="2018-12-05" version="1">MKKYFKGFLMAISMFTIIPLPYYQWDDEGAKHILKFYPFIGFVIGLIWYGIYKLTVLLGMSTMLSSAITMIIPFVITGMLHLDGYMDVCDALLSRRDKEEKIRILKDPNTGAFAVISLGILFIVDFAAIYTIVDNNINTLGFILIPIISRGLMGLLLICKNPMKESSLGAYFRKDTGKFDKLILVGILIIVSIAFYLIFNIKALIIPILMIISGLLVVRSSANELGGMSGDSAGYGLVISELIGVLFLTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ4</accession>
    <name>A0A386PIQ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy metal transport/detoxification protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Heavy-metal-associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11515</name>
        <name evidence="4" type="ORF">EI377_06330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1504.GCA_900092375_02861"/>
    <dbReference type="EnsemblBacteria" id="AYE34991">
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        <property type="gene ID" value="CP523_11515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60384">
        <property type="protein sequence ID" value="QAS60384"/>
        <property type="gene ID" value="EI377_06330"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cu-bd"/>
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        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7568" checksum="D98B208FA0024B8D" modified="2018-12-05" version="1">MKKKILIEGMSCNHCVSHVKEALEALEGVSQVDVNLEGKYATIETKVFDNVVLKEAIEEEGYDVISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ5</accession>
    <name>A0A386PIQ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1573 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08840</name>
        <name evidence="2" type="ORF">EI377_03595</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678106.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02708"/>
    <dbReference type="EnsemblBacteria" id="AYE34516">
        <property type="protein sequence ID" value="AYE34516"/>
        <property type="gene ID" value="CP523_08840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59918">
        <property type="protein sequence ID" value="QAS59918"/>
        <property type="gene ID" value="EI377_03595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="14961" checksum="9A0EEA975F149F93" modified="2018-12-05" version="1">MKDIIFDNFQNDVNESLIRHKSILDIMTKYTESSARVNRAVAKSVTNCGCINISADKQATPSENDSLSDFSSSLENHLNGKLCDNCRDVIEREIGNNLFYLTSLCNSLDLNLYDILLKEEDKINTLGKFTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ9</accession>
    <name>A0A386PIQ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ERCC4-type nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13110</name>
        <name evidence="2" type="ORF">EI377_07980</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35287">
        <property type="protein sequence ID" value="AYE35287"/>
        <property type="gene ID" value="CP523_13110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60681">
        <property type="protein sequence ID" value="QAS60681"/>
        <property type="gene ID" value="EI377_07980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="25834" checksum="A25D4EE1C95FF25D" modified="2018-12-05" version="1">MRYKFSDKEIKEILDKMVIIVDTREQANTHIIQWLQKKKKPYKTQKLDYGDYSCYLPAGSFKGQQRDVYFTNDIAIERKFCIDEIAMNLKDNKTNINEIKKEIIDLLGKEYLEKVLKTDYNRLKYEFANMNRYGIEFFIFMEDKDFDENIRNKNYRAQYEPTTLYARIKGLEREFSTIIRPIDKSMIGSEIYNTLRYSIRNVLKHKGYIEEIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT2</accession>
    <name>A0A386PIT2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Energy-coupling factor transporter ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09130</name>
        <name evidence="9" type="ORF">EI377_03875</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678390.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00264"/>
    <dbReference type="EnsemblBacteria" id="AYE34572">
        <property type="protein sequence ID" value="AYE34572"/>
        <property type="gene ID" value="CP523_09130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59972">
        <property type="protein sequence ID" value="QAS59972"/>
        <property type="gene ID" value="EI377_03875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04520">
        <property type="entry name" value="ECF_ATPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="31000" checksum="9AD4BA2B5D51E7D7" modified="2018-12-05" version="1">MSEAMIKCNNVSFKYTLQEGGEERYAVNGVNFDVKKGEFLVILGHNGSGKSTIAKHMNALLIPSEGTVVIDGLSTSDVNNLWDIRAKAGMVFQNPDNQLVATIVEEDVAFGPENLGIPPAEIRKRVDDSLEKVGMSEYKRHAPHLLSGGQKQRIAIAGILAMQPDCIIFDEPTAMLDPSGRKEVIKNIKEINEKYGITIVLITHYMDEAAQADRVLVMDNGKVILEGVPREVFSKVETMKEIGLDVPQVTELCYELKKSGIDIDTNILNVDEMVNALCQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ1</accession>
    <name>A0A386PIZ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR03987 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12225</name>
        <name evidence="3" type="ORF">EI377_07045</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673574.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35121">
        <property type="protein sequence ID" value="AYE35121"/>
        <property type="gene ID" value="CP523_12225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60512">
        <property type="protein sequence ID" value="QAS60512"/>
        <property type="gene ID" value="EI377_07045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023813">
        <property type="entry name" value="CHP03987"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03987">
        <property type="entry name" value="TIGR03987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="130" mass="14411" checksum="E913C0776B1A0079" modified="2018-12-05" version="1">MDSKLILAIVAITLALVFYTIGVFGERRSKSLNKNHVLIFWLGLICDTTGTVTMSKIAAEGVTEISKSAQVIHGVTGLLAIVLMLFHAVWATWVLYKNDEDKKVAFHKFSIAVWMVWLVPYIVGAIIGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ8</accession>
    <name>A0A386PIZ8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mntP</name>
        <name evidence="9" type="ORF">CP523_12275</name>
        <name evidence="10" type="ORF">EI377_07100</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673601.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03011"/>
    <dbReference type="EnsemblBacteria" id="AYE35131">
        <property type="protein sequence ID" value="AYE35131"/>
        <property type="gene ID" value="CP523_12275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60523">
        <property type="protein sequence ID" value="QAS60523"/>
        <property type="gene ID" value="EI377_07100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="203" mass="22285" checksum="7067A1012533B5BE" modified="2018-12-05" version="1">MSFLSIFMMGIGLSMDAFAVALAKGMNLRKNLTKNAMKIAIFFGVFQGVMPLIGWWAGRYFESYIKSFDHWIAFILLGIIGGKMIYESVKGENEDDIKCDEIKEEVSVDTNIEENEELNNKNLIILAIATSIDALAVGVSFAFLSVNIAPAITIIGLITFTLCIIAVLIGKKIGGLLQKYAEIIGGVILILIGTKILIEHLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ48</accession>
    <name>A0A386PJ48_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="10">NN:DBI PRT</shortName>
            <ecNumber evidence="4 10">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">cobT</name>
        <name evidence="11" type="ORF">CP523_12930</name>
        <name evidence="12" type="ORF">EI377_07810</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678219.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03026"/>
    <dbReference type="EnsemblBacteria" id="AYE35254">
        <property type="protein sequence ID" value="AYE35254"/>
        <property type="gene ID" value="CP523_12930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60649">
        <property type="protein sequence ID" value="QAS60649"/>
        <property type="gene ID" value="EI377_07810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12930"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="367" mass="39717" checksum="D1183FB65E52C68C" modified="2018-12-05" version="1">MNNKNSLVNFINNINPINEEVMEETRKRLDSLAKPLGSLGKLEDIAVKLSGITGKVKNKIKKKCIIILSSDNGVVEEGVASAPQYVTLAQTINFTKGLTGVAVIAKEGNSDLMVVDVGVNTDKKIHGVIDRKIRKGTNNISKEPAMTYEECIKAISIGIEMVERANNYGYDILGVGEMGIGNTTTSSAVLIALTNCDIKYAIGKGAGITNLAFEKKKEVIKKALEINKPNKSDPIDVLSKVGGFDLAAMAGVFIGAAYYRIPVVIDGFISSVAALAAVRMNPLIREYLIPSHLSKEIGYNIAMKELNLEPMVNLDMRLGEGSGCPIAFSIVDYACAVISNMATFEEAEIDSSYLDEVREKENYIVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJA5</accession>
    <name>A0A386PJA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="5">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB</name>
        <name evidence="4" type="ORF">CP523_10130</name>
        <name evidence="5" type="ORF">EI377_04930</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1504.GCA_900092375_00355"/>
    <dbReference type="EnsemblBacteria" id="AYE34732">
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        <property type="gene ID" value="CP523_10130"/>
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    <dbReference type="EnsemblBacteria" id="QAS60133">
        <property type="protein sequence ID" value="QAS60133"/>
        <property type="gene ID" value="EI377_04930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
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        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="16090" checksum="3B184312D59F6B36" modified="2018-12-05" version="1">MKIALGSDHGGIELKEEIINYLKSEGYEIKDFGTCTKDSCDYPDYAVPVAEAVAAKEFDFGILVCGTGIGIGIAANKVPGIRAALCSDTFSAHATREHNNANILTLGQRVVGPGLALDIVKTFLNTKFEGGRHQTRIDKISDVEKQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJA8</accession>
    <name>A0A386PJA8_CLOSE</name>
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        <submittedName>
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        </submittedName>
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    <gene>
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        <name evidence="7" type="ORF">EI377_07900</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Clostridia</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE35271">
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        <property type="gene ID" value="CP523_13025"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
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        <location>
            <begin position="8"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="296"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="329" mass="36806" checksum="440EA99B1FD82703" modified="2018-12-05" version="1">MKVLAYCVRPDEISSFEEFSKKFNHEVNILKDSFSKETAYLAKGYDAVSILGNDNANREAIEEIAKLGVKYLATRSAGINNIDLDAAKENNIRVSNVPAYSPNSVAEFTVGITLCLARNLKKAFKRVESQNFSLNGLIGFELRNKTIGIIGTGRIGQTVIQGFSGFGAKLIGYDLYQNENATKYIEYKSLDEVFKEADIITLHCPLTKDNYHLINKKNIEKMKDGVVLINTSRGQLMNTEDVIEGIKSGKIAGLATDVYENEYGIFHSDHQNDILKDETLLALKSFPNVIVTPHYGFYTDEAVSNMVEYSLENLYDFETKKQCKNEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB5</accession>
    <name>A0A386PJB5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF488 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13360</name>
        <name evidence="2" type="ORF">EI377_08250</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="1" key="1">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00767"/>
    <dbReference type="EnsemblBacteria" id="AYE35334">
        <property type="protein sequence ID" value="AYE35334"/>
        <property type="gene ID" value="CP523_13360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60725">
        <property type="protein sequence ID" value="QAS60725"/>
        <property type="gene ID" value="EI377_08250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="205" mass="24051" checksum="BF2E63F6FAB757F2" modified="2018-12-05" version="1">MDIFTIGHSNYTVEKLIDMLKHYDINCVVDIRGTPYSKYNIQFDKENIKYTLNKEGFIYIYMAKELAAKRENKISYNNEGYSDFEKVVYENEFINGIKRLKDGCTKGYRIALLGAMQDPIRCHRSILVGRALRKEGFNVKHIIDDYSIISQDKIESNILDKYFNNRAQLTIDYLLGNDLTEEEMINEGYRLANKEIGYRIEHLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB9</accession>
    <name>A0A386PJB9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14635</name>
        <name evidence="3" type="ORF">EI377_09600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35567">
        <property type="protein sequence ID" value="AYE35567"/>
        <property type="gene ID" value="CP523_14635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60953">
        <property type="protein sequence ID" value="QAS60953"/>
        <property type="gene ID" value="EI377_09600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="13351" checksum="77C1B88631653327" modified="2018-12-05" version="1">MSISTIKLLLIGIFILTVMVILGTIKLKSCPGIVKATKEQRIKGIGLIKSLWKKQIIISSVAIALYLITFMVNDKTEDMFLKTIILLSSAFVAGSGFYIVYCYNKFKGNFSKLMDEIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ4</accession>
    <name>A0A386PJJ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13865</name>
        <name evidence="3" type="ORF">EI377_08760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35424">
        <property type="protein sequence ID" value="AYE35424"/>
        <property type="gene ID" value="CP523_13865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60812">
        <property type="protein sequence ID" value="QAS60812"/>
        <property type="gene ID" value="EI377_08760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012851">
        <property type="entry name" value="Spore_coat_CotF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07875">
        <property type="entry name" value="Coat_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="83" mass="9551" checksum="DA093D0E55D86754" modified="2018-12-05" version="1">MKEKDIMNDYLSMINSSLTGYASIIAQTDNQELRQTIQQMRNEDEIRQCKVYQTAKEKGYYKPAQPANQNDINTVKSEVTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN1</accession>
    <name>A0A386PJN1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678730.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03064"/>
    <dbReference type="EnsemblBacteria" id="AYE35707">
        <property type="protein sequence ID" value="AYE35707"/>
        <property type="gene ID" value="CP523_15405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012851">
        <property type="entry name" value="Spore_coat_CotF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07875">
        <property type="entry name" value="Coat_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="83" mass="9653" checksum="3760A1D10BD8675C" modified="2018-12-05" version="1">MKEKDIMNDYLSMINSSLTGYASIIAQTDNQELRQTIQQMRNEDEIRQYKVYQTAKEKGYYKPAQPADQNDINTVKSELTANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX3</accession>
    <name>A0A386PJX3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04570</name>
        <name evidence="2" type="ORF">EI377_15120</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35817">
        <property type="protein sequence ID" value="AYE35817"/>
        <property type="gene ID" value="CP523_04570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62237">
        <property type="protein sequence ID" value="QAS62237"/>
        <property type="gene ID" value="EI377_15120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022118">
        <property type="entry name" value="Peptidase_C70_AvrRpt2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12385">
        <property type="entry name" value="Peptidase_C70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="32318" checksum="B04D9A19ED8AF436" modified="2018-12-05" version="1">MGYGVFNSIFYNEDLEKEKKVEEINKVVKVEKSEKPEQPKQPEEVDYLSKIPEEIKNSNDLMIQKLLQKANDNQKVAMMLSDIKSYPKQLLELASKKDEVIDFVANYPNHKKSKGENISIIKDYKKGEIPLFIQWDERWGYENYGSEFIAINGCGPTSLAMVAVGLTGNTHINPKVVSDSSEKNGYLVEGVGSDWKLMTEGAIEFGVNGRELPLSADAIISTLQSGQPIIASMAPGVFTTTGHYIVLTGVDSNNKIIVNDPDSKIKSKQAWDLDVFMRETDNLWAFTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX7</accession>
    <name>A0A386PJX7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14480</name>
        <name evidence="8" type="ORF">EI377_09455</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676837.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02489"/>
    <dbReference type="EnsemblBacteria" id="AYE35541">
        <property type="protein sequence ID" value="AYE35541"/>
        <property type="gene ID" value="CP523_14480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60927">
        <property type="protein sequence ID" value="QAS60927"/>
        <property type="gene ID" value="EI377_09455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="305" mass="33402" checksum="58C521379CACD165" modified="2018-12-05" version="1">MVKYIGKRILTSILTIWVVVTLTFFLIRMMPGGPFNTDKMTPEIKANLNAKYGLDKPIGEQYTMYMKNLLKGDLGESMIFKGRQVKNTIKYSAPKSAKVGVVAILVSLAAGVILGIISALNAGKWPDRLCMVLATLGITIPSFVIGAVLIYIFTVKLRLLPATGLSSWKNYIMPVIALSLSSMAFITRLTRSKLIDVLKSDYIRTAKAKGLSGRTVIFKHALRNSLIPIVTYLGPLVAGVLTGSFVIEKIFVIPGLGNEFTLTVINRDYSALLGVLVFYSTLIVVANLVVDILYVIIDPRIKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJY5</accession>
    <name>A0A386PJY5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14545</name>
        <name evidence="2" type="ORF">EI377_09515</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678677.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35551">
        <property type="protein sequence ID" value="AYE35551"/>
        <property type="gene ID" value="CP523_14545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60937">
        <property type="protein sequence ID" value="QAS60937"/>
        <property type="gene ID" value="EI377_09515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="163" mass="18518" checksum="5FEE2CAF158FBDB2" modified="2018-12-05" version="1">MLQNLGVLTLAMFLFNLSPGTIENTPKKIEAKNPRVISEMSAKVETVKEETKKANYKDITVYITYYTNINDSLQGGHNDRIGVPLKDHGENVIAMPEDVPYGSYLDIEDMGEFKVVDTGEAIVWLDDSTCKVDVFIPDVDYEWIYTNTENTVKKARLYLNKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ1</accession>
    <name>A0A386PJZ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cardiolipin synthase</fullName>
            <shortName evidence="12">CL synthase</shortName>
            <ecNumber evidence="12">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls</name>
        <name evidence="14" type="ORF">CP523_06735</name>
        <name evidence="15" type="ORF">EI377_01210</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phospholipase D family. Cardiolipin synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01567"/>
    <dbReference type="EnsemblBacteria" id="AYE35837">
        <property type="protein sequence ID" value="AYE35837"/>
        <property type="gene ID" value="CP523_06735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62145">
        <property type="protein sequence ID" value="QAS62145"/>
        <property type="gene ID" value="EI377_01210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01916">
        <property type="entry name" value="Cardiolipin_synth_Cls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030874">
        <property type="entry name" value="Cardiolipin_synth_Firmi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS62145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="477" mass="54585" checksum="859F49CB3FF57B8B" modified="2018-12-05" version="1">MFIIILVSIILINLILVSTIVILEKKRPEKTIAWILILLFLPPIGLILYVFLGRNWKINTLNKGVPDNLKKLISSIIYSNNETLKDYPSLIKLLATNSYSPLFINNEIEVFDGGIEKFKVLKKELLKAKDHIHLEYYIVKNDKIGNEIKNILIKKAHEGVKIKFIIDRVGSIRLKASYIKDLRNAGIDVVFYSYVFAPLLRLINTQINYRNHRKIVVIDGTIGFIGGINIGDEYLNKGKLGEWRDCHIMIKGDAVLALQGTFLDDYSSIKKCNSENLNLSKDIKHYFPKSNFSGNVIMQVIKSGPNSEFPSIMQSIIKMVSMAEEYINIMTPYFIPSEGLIDALRISALSGVKINLIFPEQADHFTVHHASLTYLSELLRCGAKVYLYNKKGFIHSKVIIIDGKLCNIGTANMDIRSFELNYEINTVIYNKEITKKFNNIFLKDLKNCREYTLREYENQTILNKMLNGLCRLFSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK54</accession>
    <name>A0A386PK54_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11910</name>
        <name evidence="2" type="ORF">EI377_06730</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673449.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35062">
        <property type="protein sequence ID" value="AYE35062"/>
        <property type="gene ID" value="CP523_11910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60455">
        <property type="protein sequence ID" value="QAS60455"/>
        <property type="gene ID" value="EI377_06730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="110" mass="12613" checksum="FE19D44AF98717B9" modified="2018-12-05" version="1">MAKYKVGDELIEITDPSQEANKLKELTYLNTDGDYAQISWGLKIINVEYEKPYVTLTYKNFNGELNKVFAECRDIANFDKEKVLEKALLKAFTNEIINISVVKNTGCKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK72</accession>
    <name>A0A386PK72_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="5">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mgtA</name>
        <name evidence="16" type="ORF">CP523_13650</name>
        <name evidence="17" type="ORF">EI377_08540</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + Mg(2+)(out) = ADP + H(+) + Mg(2+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02092"/>
    <dbReference type="EnsemblBacteria" id="AYE35388">
        <property type="protein sequence ID" value="AYE35388"/>
        <property type="gene ID" value="CP523_13650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60777">
        <property type="protein sequence ID" value="QAS60777"/>
        <property type="gene ID" value="EI377_08540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02077">
        <property type="entry name" value="P-type_ATPase_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="741"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="806"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="15">
        <location>
            <begin position="13"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE35388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS60777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="872" mass="97507" checksum="AB5680BB225FEDD5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE4</accession>
    <name>A0A386PKE4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIR</name>
        <name evidence="3" type="ORF">CP523_10065</name>
        <name evidence="4" type="ORF">EI377_04865</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676577.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00342"/>
    <dbReference type="EnsemblBacteria" id="AYE34719">
        <property type="protein sequence ID" value="AYE34719"/>
        <property type="gene ID" value="CP523_10065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60120">
        <property type="protein sequence ID" value="QAS60120"/>
        <property type="gene ID" value="EI377_04865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014202">
        <property type="entry name" value="Spore_II_R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09551">
        <property type="entry name" value="Spore_II_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02837">
        <property type="entry name" value="spore_II_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362786" evidence="2">
        <location>
            <begin position="26"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="24783" checksum="D5D5026FB4DC6CC7" modified="2018-12-05" version="1">MKKKFLVLISIIFVIGFFISCESQNSGQSIDGKVEVNYEDVADQIIRFHVIANSDSEEDQALKLKVRDKVVEYASSKLSDCENLDEARKEILNDKDEMERIAREVIEENGYDYNVISMLSRENFPDKMYGDLVFPQGEYEAYRILIGDASGQNWWCVMFPPLCFVDGTKDAIKTNDTEKKLEKLIDEAESNNEKEEPKVEFKFKFLESLKGLSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKH0</accession>
    <name>A0A386PKH0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0371 protein CP523_15755</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15755</name>
        <name evidence="3" type="ORF">EI377_10470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0371 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678917.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35774">
        <property type="protein sequence ID" value="AYE35774"/>
        <property type="gene ID" value="CP523_15755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61112">
        <property type="protein sequence ID" value="QAS61112"/>
        <property type="gene ID" value="EI377_10470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01567">
        <property type="entry name" value="UPF0371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014999">
        <property type="entry name" value="UPF0371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08903">
        <property type="entry name" value="DUF1846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033132">
        <property type="entry name" value="DUF1846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="502" mass="56510" checksum="E8C2D5A4ACB4E00E" modified="2018-12-05" version="1">MKLGFDPKKYLEEQSKFILERVNDYDKLYLEFGGKLMCDLHAKRVLPGFDEDAKIKLLHKLKEKVEVVICVYAGDIERNKIRGDFGITYDLEVFRLIDDLRAYELDVNSVVITRYNGQPATTVFINKLERRGIKVYKHKATKGYPADVDTIVSDEGYGKNPYIETTKPIVVVTAPGPGSGKLATCLSQLYHEYRRGNVAGYSKFETFPVWNVPLKHPLNIAYEAATVDLKDVNLIDSFHMDAYNKLAVNYNRDIESFPLLKRIIEKITGEESVYKSPTDMGVNRVGYGIVDDEVVKEASKQEIIRRYFKTACEYKKGYVDKETADRAKLIMEELNLKESDRKVVIPSREHAAKLKELSDKNEISTAVALELIDGTILTGKESELMDASAAVILNAIKYLANINDDIHLISPVILEPIINLKSKTFGNKNTALTCEEILIALSICAATNPTAQAALNKLSMLKGCQAHSTTIVNGSDDQTFRKLGIDITCDPEYQTDNLYYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP2</accession>
    <name>A0A386PKP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2520 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07820</name>
        <name evidence="4" type="ORF">EI377_02510</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02103"/>
    <dbReference type="EnsemblBacteria" id="AYE35844">
        <property type="protein sequence ID" value="AYE35844"/>
        <property type="gene ID" value="CP523_07820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62152">
        <property type="protein sequence ID" value="QAS62152"/>
        <property type="gene ID" value="EI377_02510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018931">
        <property type="entry name" value="DUF2520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019665">
        <property type="entry name" value="OxRdtase/DH_put_Rossmann_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037108">
        <property type="entry name" value="TM1727-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10728">
        <property type="entry name" value="DUF2520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10727">
        <property type="entry name" value="Rossmann-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rossmann-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2520" evidence="2">
        <location>
            <begin position="133"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="31918" checksum="4F34ECD1B0853EA1" modified="2018-12-05" version="1">MKIGFIGAGKVGFSLGKYLTENNITVTGYYSRNEDSAYEASIFTKTKQYNNLKEIINESDAIFITTPDREIQKVWNEIKKLSIQNKLICHCSGSLSSSIFSNINQYGAYGYSIHPMLAISDKYNSYKNLKEAFITIEGHEKYRNKFKRLIESLGNKATIISNENKALYHAASVIVSNLVLGLINNSVSYLEQCGFKEEEAINALYPLIIFNVKNIREKGIKNSLTGPIERGDLSTIKSHCKSLSSEDEIMYKILSKNILEIAKVKNKNRDYKELEEYLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKV5</accession>
    <name>A0A386PKV5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679048.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35316">
        <property type="protein sequence ID" value="AYE35316"/>
        <property type="gene ID" value="CP523_13260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017386750" evidence="1">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="176" mass="19957" checksum="06ED898615A64153" modified="2018-12-05" version="1">MKKILSIFLFLIISLGLVSCKSGEDLKAKTDKEVINNSDIDKKENINEKVTYNVDWEKCIHDTKAEFINSEQYSYLKDIYIEVSGDKVTFTAVLADSTDSKLALDLADSIIRRFNANAQLQDSSVKSSGKDYLGGLYDNYTISIGIAPLSEVKNQSKWYIYDAIEKKVHREPKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL01</accession>
    <name>A0A386PL01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_11555</name>
        <name evidence="8" type="ORF">EI377_06370</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673335.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02869"/>
    <dbReference type="EnsemblBacteria" id="AYE34999">
        <property type="protein sequence ID" value="AYE34999"/>
        <property type="gene ID" value="CP523_11555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60392">
        <property type="protein sequence ID" value="QAS60392"/>
        <property type="gene ID" value="EI377_06370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="276"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="491"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="570" mass="63031" checksum="C639782D7505F728" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLF5</accession>
    <name>A0A386PLF5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12905</name>
        <name evidence="6" type="ORF">EI377_07785</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678229.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03031"/>
    <dbReference type="EnsemblBacteria" id="AYE35249">
        <property type="protein sequence ID" value="AYE35249"/>
        <property type="gene ID" value="CP523_12905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60644">
        <property type="protein sequence ID" value="QAS60644"/>
        <property type="gene ID" value="EI377_07785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="651" mass="74564" checksum="989BAECED9A9E17E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLL3</accession>
    <name>A0A386PLL3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FprA family A-type flavoprotein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13435</name>
        <name evidence="4" type="ORF">EI377_08330</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677562.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00782"/>
    <dbReference type="EnsemblBacteria" id="AYE35349">
        <property type="protein sequence ID" value="AYE35349"/>
        <property type="gene ID" value="CP523_13435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60740">
        <property type="protein sequence ID" value="QAS60740"/>
        <property type="gene ID" value="EI377_08330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="249"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="390" mass="44388" checksum="BD7B56B685AE020E" modified="2018-12-05" version="1">MSAELLKNNIYWVGVKDPNLKIFDIIMETKKGTTYNSYLINDEKIAVVDTVKNGYYDEFKKNLTEVIGDKKVDYVIVHHTELDHSGSLIKLIEDYPEIKVVASKAALNYLKNILNIEFNAIEAKEDLVLGKTTLKFIMAPNLHWPDTMFTYIEDEKFIFTCDFTGCHYSPIAKMCDSFGDDYFEEMKYYFDCIMGPFKRFVNMGLDKIKDLEIEIIAPSHGPVHISNIDKILNLYREWAKEVPVDNKKVEIFYISAYGNTEAMANFMKEKLEEKGFKADVTEITSIPLEECAAKIERAKGFMVGSPTINQDAVKPSWDLLSVVSPVVNRGKAALAFGSYGWSGEGVKMLTSRLKELKLKTVDPGLSFCFVPSKEEYKKAEEAVNSFIELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLY1</accession>
    <name>A0A386PLY1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,3-beta-glucanase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07880</name>
        <name evidence="4" type="ORF">EI377_02570</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675990.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00679"/>
    <dbReference type="EnsemblBacteria" id="AYE35846">
        <property type="protein sequence ID" value="AYE35846"/>
        <property type="gene ID" value="CP523_07880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62153">
        <property type="protein sequence ID" value="QAS62153"/>
        <property type="gene ID" value="EI377_02570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="126"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="564" mass="63200" checksum="9CA3404517EC8C42" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMC3</accession>
    <name>A0A386PMC3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05600</name>
        <name evidence="2" type="ORF">EI377_00035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35829">
        <property type="protein sequence ID" value="AYE35829"/>
        <property type="gene ID" value="CP523_05600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62137">
        <property type="protein sequence ID" value="QAS62137"/>
        <property type="gene ID" value="EI377_00035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="129" mass="13740" checksum="EB2405EB6033736F" modified="2018-12-05" version="1">MEGVSKTNWNSKEFLDELANSGVKYNADDLVAVTKTPDGKLVWLENGNSQAGLNHVMNHADDFAKKGIAKDEITDLVMTALNKGEIVGYQGKGTGRPIYKVTFNGETQGVAITVGSNGFIVGANPKSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAL1</accession>
    <name>A0A386PAL1_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00065</name>
        <name evidence="4" type="ORF">EI377_10545</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678950.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00300"/>
    <dbReference type="EnsemblBacteria" id="AYE32955">
        <property type="protein sequence ID" value="AYE32955"/>
        <property type="gene ID" value="CP523_00065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61127">
        <property type="protein sequence ID" value="QAS61127"/>
        <property type="gene ID" value="EI377_10545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="132"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE32955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="298" mass="33171" checksum="B7F0370FBA9A196F" modified="2018-12-05" version="1">MDKNLNDSSKDLMRLIQLRFSRLSKGQKLIAEYILKNYDKAAFMTAAKLGTSVGVSESTVVRFANELGFTGYPKLQKALQELIKNKLTTVQRLELSNDYISEGYALKGVLKADMENIRSTLEKINYNTFEDVINKIFEAKRIYIIGLRSSTALAEFLGFYLNIILQNVKTVGYGISDIFEQMINVGEGDLVIGIGFPRYASKTIDALSFSQDRGAKVVAITDSLLSPLASKADYTLIAQSNMASFVDSLVAPLSVINALIIAVGMREKENIATTFNNLEQIWKGYNVYSYNNRNVGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBB0</accession>
    <name>A0A386PBB0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_01430</name>
        <name evidence="7" type="ORF">EI377_11950</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675603.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00838"/>
    <dbReference type="EnsemblBacteria" id="AYE33213">
        <property type="protein sequence ID" value="AYE33213"/>
        <property type="gene ID" value="CP523_01430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61385">
        <property type="protein sequence ID" value="QAS61385"/>
        <property type="gene ID" value="EI377_11950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26723" checksum="9336D3DAE533FD4B" modified="2018-12-05" version="1">MIREINLYSLNSKYAYVHPIEKILLVLISLIICSYIENIYLITGNIIFFILLNLIAKNPFKIINKFLVIAIVFSIFTTISLLWQGYSLNYIILILIRGINGAITISFLALTTPINHIVCVMSRWEYIRDVADIIKSMERFIIILEDDLTITFNAIKSRGGFSGFKNSVKDFGNVLGVSFKNLVFRWREINLALKNRCYIGRHNYSYSFKISKLRLSFLLVYILVLGFINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBC4</accession>
    <name>A0A386PBC4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiA</name>
        <name evidence="6" type="ORF">CP523_01490</name>
        <name evidence="7" type="ORF">EI377_12010</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675628.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00850"/>
    <dbReference type="EnsemblBacteria" id="AYE33225">
        <property type="protein sequence ID" value="AYE33225"/>
        <property type="gene ID" value="CP523_01490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61397">
        <property type="protein sequence ID" value="QAS61397"/>
        <property type="gene ID" value="EI377_12010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01490"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="239"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="428" mass="48252" checksum="4B025BA01DE3A830" modified="2018-12-05" version="1">MKTIIISSNCSGGGKTTFTLGLMKALKNRNYKVQGFKSGPDYIDTGFHTEITGQNSRNLDLHLMGEDGVKASFSRGNGDVAIIEGAMGLYDGIGITEECSTYSISKTLNNAPILLVISPKAQSTTLCAEINGIKDFRNANIIGVVLNSISESYYNLLKKNIEVNCNLKVFGYIPKEESIKLSSRHLGLVQSIEVDNLKDKIQICADLIEKNINLDELIKEFKYIEKYEDKFHIGNKNLKIAVAYDEAFRFYYKENLELLEEAGEVIYFSPLKDSKLPENIDFLYLGGGYPEVFKEELSKNKSMLNSIKNALESGVKCYGECGGLMYLTEKIDNVPMVGFFSGESCMTSRLNRFGYASIEVNGIKINCHEFHKSKVDLNEKTIYKVYKNMYTGEKKTWECGYEKNNTLAGYPHIHFFSNMEFLRCLLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBG4</accession>
    <name>A0A386PBG4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_01705</name>
        <name evidence="10" type="ORF">EI377_12225</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677349.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02410"/>
    <dbReference type="EnsemblBacteria" id="AYE33265">
        <property type="protein sequence ID" value="AYE33265"/>
        <property type="gene ID" value="CP523_01705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61436">
        <property type="protein sequence ID" value="QAS61436"/>
        <property type="gene ID" value="EI377_12225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="25872" checksum="ECE677C6ED926FF3" modified="2018-12-05" version="1">MANILIVDDEKSIRDLIVLTLKLENYSTMEASNGEIALNLINEFNFDLILLDIMLPKMNGLKLFQEIKHKKIPVIFLTAKCSLQDKILGLKLGAEDYITKPFEPLELLARIEVILRRKTNYYSDDTNILRFQHITILTNERIVKNNNNEISLTVKEYNLLVEFIKNINVVLSRECLLNTVWGYDFYGETRTVDMHVKQLREKLNLKNYLVTVYKVGYKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBI1</accession>
    <name>A0A386PBI1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677282.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02380"/>
    <dbReference type="EnsemblBacteria" id="AYE33293">
        <property type="protein sequence ID" value="AYE33293"/>
        <property type="gene ID" value="CP523_01855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="89"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="311" mass="35830" checksum="4D2FF834D84D745D" modified="2018-12-05" version="1">MIILILIAIVVVFISIVLYFINKKAFYKVIMDKRKTKDEMIEAMKERFLSDYNDYENLEYDELTIKSYDGYNLKGYYYAPNKDSKKIAIIHHGYTANHYVCFQFADIFFEEGFNVLLIDMRSHGESEGKHITYGYKESRDLDKWVDLMREKVGEDGIIGLHGQSMGGATVLMYGGRYSSKIDFIIADCAYSNGVAMMKSQFKEAKVPFFPVYYILNRKLKKICGFDMNKISPIDDIKNSDVPVMFVHGTADELVPHSMSEEMYNVKKGDKNKLVLIEGAKHVGAYSKSKKLYKEAVKSFIDNAIEVKKYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBP5</accession>
    <name>A0A386PBP5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_02195</name>
        <name evidence="14" type="ORF">EI377_12715</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674042.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00528"/>
    <dbReference type="EnsemblBacteria" id="AYE33355">
        <property type="protein sequence ID" value="AYE33355"/>
        <property type="gene ID" value="CP523_02195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61525">
        <property type="protein sequence ID" value="QAS61525"/>
        <property type="gene ID" value="EI377_12715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="133" mass="14794" checksum="FBFF6CCBB693B073" modified="2018-12-05" version="1">MNYNELIQKAIEARELAYCPYSNFKVGAAALFENGEIYTGCNIENASFGGTNCAERTAIFKGVSEGNKKLKALALIGDIKSFTYPCGICRQVISEFVESEDTPIIIIKNKEEYIVKTFKEIMPGAFTQKDLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC39</accession>
    <name>A0A386PC39_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03045</name>
        <name evidence="9" type="ORF">EI377_13545</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678432.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01768"/>
    <dbReference type="EnsemblBacteria" id="AYE33513">
        <property type="protein sequence ID" value="AYE33513"/>
        <property type="gene ID" value="CP523_03045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61679">
        <property type="protein sequence ID" value="QAS61679"/>
        <property type="gene ID" value="EI377_13545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="237" mass="27431" checksum="CE26881006E2DF00" modified="2018-12-05" version="1">MNCIIVDDELPAREELKYFIKNFSSMDILSEFEDGTEALKFLQANSVDIIFLDINIPGIDGINLAKILCKLNFSGKVIFITAYKEYALDAFDIHAFDYLLKPFSEERIISSLERIEDSRDEKLNNDRKSDKLSVMRNGKIYVVNTKDICYLEASGRTVKVCVNGEEYLSKHKISEIESKLSNKEFYKSHRSYIVNLGKVEEIKPWFNGTYVLKIKDIEKEVPVSRNKVKDFKRILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCD1</accession>
    <name>A0A386PCD1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar biosynthesis/type III secretory pathway-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02605</name>
        <name evidence="3" type="ORF">EI377_13140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673912.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00446"/>
    <dbReference type="EnsemblBacteria" id="AYE33430">
        <property type="protein sequence ID" value="AYE33430"/>
        <property type="gene ID" value="CP523_02605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61604">
        <property type="protein sequence ID" value="QAS61604"/>
        <property type="gene ID" value="EI377_13140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="252" mass="28742" checksum="A3717C9B03F8969D" modified="2018-12-05" version="1">MQSSYNLIKKSGAHSGGSKPIETNYVNEKIKEQKEHIEKNIIDIDAMVKKYENLGANIIKNAKAEAEKITIASTKKAIEIERLAYEKGYEQGKQNGYEDGYKSGYDTVMQDTKEKVLEDLKLAEYVLSTAKDDYKTYMNEKKDAILKLSLDMAKIIAGKEFQLEDGILQLIEPILEDSIGEENIIIKFNPTYKEKIMEKTDYWKKAYRLKGEIFLLEDPFMEIGNAVIEKNTGKVVVGMDVALEKLEEALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCG7</accession>
    <name>A0A386PCG7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">murG</name>
        <name evidence="13" type="ORF">CP523_02810</name>
        <name evidence="14" type="ORF">EI377_13335</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676986.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00968"/>
    <dbReference type="EnsemblBacteria" id="AYE33470">
        <property type="protein sequence ID" value="AYE33470"/>
        <property type="gene ID" value="CP523_02810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61641">
        <property type="protein sequence ID" value="QAS61641"/>
        <property type="gene ID" value="EI377_13335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02810"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="190"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="360" mass="40152" checksum="72FCE94BEEFE8CCC" modified="2018-12-05" version="1">MSKYKIIMTGGGTAGHVTPNLALVPKLKEKGFEVKYIGSKTGIEKEIITDAKIPYYEISSGKLRRYFDFKNFTDPFKVMKGILEAKKILKEEKPDVIFSKGGFVAVPVVIAASMKKIPVVSHESDLTPGLANKLSAPFCNRLCVTFRESLNYIKDGKGVLTGTPIRHEILEGSKLRGKEICGFKDNKDILLVIGGSLGAKSINEEIRRDLDEILKMFNVIHVCGKGNLDKKLENTVGYKQFEYVKEDLPHLLKSANFVVSRAGANVIFELLALKKPTLLIPLSKKISRGDQILNANSFEKEGYSLVLDEDEMQESHNLIIKLKELKEKSNYLAKNMENSNLKNGVDAILEVILNSMELNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCH7</accession>
    <name>A0A386PCH7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF</name>
        <name evidence="9" type="ORF">CP523_02865</name>
        <name evidence="10" type="ORF">EI377_13390</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677004.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00979"/>
    <dbReference type="EnsemblBacteria" id="AYE33480">
        <property type="protein sequence ID" value="AYE33480"/>
        <property type="gene ID" value="CP523_02865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61651">
        <property type="protein sequence ID" value="QAS61651"/>
        <property type="gene ID" value="EI377_13390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="207"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="599" mass="69411" checksum="AA3F5854B26CCA17" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCS0</accession>
    <name>A0A386PCS0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purN</name>
        <name evidence="5" type="ORF">CP523_01770</name>
        <name evidence="6" type="ORF">EI377_12290</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677323.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02397"/>
    <dbReference type="EnsemblBacteria" id="AYE33277">
        <property type="protein sequence ID" value="AYE33277"/>
        <property type="gene ID" value="CP523_01770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61448">
        <property type="protein sequence ID" value="QAS61448"/>
        <property type="gene ID" value="EI377_12290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01770"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="203" mass="22369" checksum="2655A934B5CDD67A" modified="2018-12-05" version="1">MFKIAVLASGSGSNLQSIIDAIENKRLNCKIEMVIGSKEEIFALDRARANAIETHVVSKKEYGDKTSDKILELTKGKVDLIVLAGYLSILQGDILKEFKGRIINIHPSLIPSFCGPSMYGIKVHEAVLKSGVKVTGCTVHFVNEEIDGGEIILQEAVKVDFEDTKEDIQKKVLAFEHKLLPRAIDLISKGNIEIINGRVKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCU0</accession>
    <name>A0A386PCU0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01880</name>
        <name evidence="3" type="ORF">EI377_12385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678297.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01172"/>
    <dbReference type="EnsemblBacteria" id="AYE33297">
        <property type="protein sequence ID" value="AYE33297"/>
        <property type="gene ID" value="CP523_01880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61466">
        <property type="protein sequence ID" value="QAS61466"/>
        <property type="gene ID" value="EI377_12385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="31654" checksum="A43E8F014714B783" modified="2018-12-05" version="1">MDERYDIAIVGSGPAGLSAALNAKIRNKKFIVFGNKNLTNKLIKAPKVNNYLGFFGMTGEDIKKQFEAHLDAMEIEITEERINSIYAMGDYFALMANDKNYEAKTVILATGMEYTRPIKGEEKYLGKGVGYCATCDAPLYRGKTVTIIGHNQEAEEEANFVSELAGLVYYIPMYRGSYKLRTNIEVVEDKPEEITGDMKVNKLVLKNSELKTDGVFVLKDSISPGQLVPGLKIEENHISVDRLMRTNIPGCFAAGDCVGKPYQYIKSAGEGNIAALSASQYLDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCW7</accession>
    <name>A0A386PCW7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">potA</name>
        <name evidence="10" type="ORF">CP523_02045</name>
        <name evidence="11" type="ORF">EI377_12565</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678872.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00123"/>
    <dbReference type="EnsemblBacteria" id="AYE33327">
        <property type="protein sequence ID" value="AYE33327"/>
        <property type="gene ID" value="CP523_02045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61497">
        <property type="protein sequence ID" value="QAS61497"/>
        <property type="gene ID" value="EI377_12565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="39607" checksum="3AEA1328DC2EB0E0" modified="2018-12-05" version="1">MEQNIIELECISKKYGDNTVLDNLSLNIKKNEFLTLLGPSGCGKTTTLKIIAGFEQADSGKVLFNGEDISTLPPYKRQVNTVFQKYALFPHMNVYENIAFGLTIKKVEKNIIDTKVKEMLKLVSLEGFEKRNIDSLSGGQQQRVAIARALVNEPEVLLLDEPLGALDLKLRKEMQIELKRIQQRLGITFIFVTHDQEEALTMSDTIIVMNKGKIQQMGSPEDIYNEPSNSFVADFIGESNIFDGVMLEDFKVKFSNKIFECVDNGFKQNEYIDVVIRPEDIKIVNSDKGMLTGIVKSVIFKGVHYEIEVLEGDNLWIIHNTKHAEVNSTIGLDIYPEDIHIMRKVRNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDC1</accession>
    <name>A0A386PDC1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33993">
        <property type="protein sequence ID" value="AYE33993"/>
        <property type="gene ID" value="CP523_05685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="128" mass="14875" checksum="ABAD11C70855D36C" modified="2018-12-05" version="1">MIIINTLEDIEKAEITPKELKKEILQQFQEIAESVVDKYWKMYNLKEVGDIVVLEDDDSIEVLNKYNIIDKQSKKITSIPEFTEVIVIDDVEIMKSTFILGDSFGITLYHKIGKLGTENEVFLKEYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDI7</accession>
    <name>A0A386PDI7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_06055</name>
        <name evidence="10" type="ORF">EI377_00535</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01912"/>
    <dbReference type="EnsemblBacteria" id="AYE34063">
        <property type="protein sequence ID" value="AYE34063"/>
        <property type="gene ID" value="CP523_06055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59434">
        <property type="protein sequence ID" value="QAS59434"/>
        <property type="gene ID" value="EI377_00535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="199"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="590"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="220"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="701" mass="81483" checksum="94A1E049156E7B00" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDN1</accession>
    <name>A0A386PDN1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cation_ATPase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03390</name>
        <name evidence="3" type="ORF">EI377_13915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00062"/>
    <dbReference type="EnsemblBacteria" id="AYE33577">
        <property type="protein sequence ID" value="AYE33577"/>
        <property type="gene ID" value="CP523_03390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61741">
        <property type="protein sequence ID" value="QAS61741"/>
        <property type="gene ID" value="EI377_13915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cation_ATPase_N" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="24831" checksum="6F8A51C3337E6E76" modified="2018-12-05" version="1">MLKVIFIYYCNLGGMGMVNGRNSNISIDKLIRFSKININDVYRILKTSIRGISNEEAELRRKKYGENKIENSLKEIKEKKYYKVTREGAEILVSVEYLTIGDVIHLNIGEYVPADVRIIHCNNLYISEYTLTGRDTLVKKHENIRGDYYLNKKITELDNICLKGTEIVKGTALGIVIAIGNNTYYSKNKSLSNFIIKRKNKKGIIRIKDMIKLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDQ1</accession>
    <name>A0A386PDQ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ribulose-5-phosphate 4-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphoribulose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">araD</name>
        <name evidence="7" type="ORF">CP523_05230</name>
        <name evidence="8" type="ORF">EI377_15790</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22368"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="EC" id="5.1.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. AraD/FucA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676247.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01835"/>
    <dbReference type="EnsemblBacteria" id="AYE33920">
        <property type="protein sequence ID" value="AYE33920"/>
        <property type="gene ID" value="CP523_05230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62071">
        <property type="protein sequence ID" value="QAS62071"/>
        <property type="gene ID" value="EI377_15790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008742">
        <property type="term" value="F:L-ribulose-phosphate 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019572">
        <property type="term" value="P:L-arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004661">
        <property type="entry name" value="AraD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00760">
        <property type="entry name" value="araD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="230" mass="26067" checksum="E0D4170FD0743DD4" modified="2018-12-05" version="1">MLEELKQKVYEANMLLPKYNLITFTWGNVSGIDREKGLIVIKPSGVEYDVMKPEDMVVVDMEGNVVEGTLNPSSDTPTHVKLYNEFKEIGGVVHTHSKWATVFAQAGRGINPYGTTQADYFYGEIPCTRDMTKNEIENNYEYNTGEVIVERFKDLNPKYMPAVLVKNHGPFTWGKDPFEAVHNAVVLEEVAMMAFTTEMIMNSGVKAMPNTLLDKHFMRKHGPNAYYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDS9</accession>
    <name>A0A386PDS9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rsmI</name>
        <name evidence="8" type="ORF">CP523_06580</name>
        <name evidence="9" type="ORF">EI377_01070</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677475.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02193"/>
    <dbReference type="EnsemblBacteria" id="AYE34163">
        <property type="protein sequence ID" value="AYE34163"/>
        <property type="gene ID" value="CP523_06580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59531">
        <property type="protein sequence ID" value="QAS59531"/>
        <property type="gene ID" value="EI377_01070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="31801" checksum="AF55A822E6C27BDF" modified="2018-12-05" version="1">MAQGKLYLVPTPIGNLKDITLRALEVLENADIIAAEDTRQSLKLLNHFNIKKSLFSYHQHNEQGKSEDIIAKLEDGLNVALVTDAGTPGISDPGSVIVTKCIERGIEFEVLPGATAITTALVYSGIDTTKFVFRGFLPRENKERKPVIEELLNVKDTLIFYEAPHRLLDTLGYLKENLGDRKIAICRELTKLHEEIYRGTISEGIKYFVENRPRGEFVLVLEGKSEEEIKAEKEALWSDLTIEEHILKFMELGIDKKEAIKKVAKERGVPKKEIYKYSTNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE39</accession>
    <name>A0A386PE39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673794.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34295">
        <property type="protein sequence ID" value="AYE34295"/>
        <property type="gene ID" value="CP523_07490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="193" mass="22927" checksum="5DB9F634C7D3984A" modified="2018-12-05" version="1">MKVKIINKDSSDFEKEFKVRRMNYDQSVVNYPNSKGINIFLNKDVKFITESDIDEFLIKYKDFLKIKLNRGISINLYKILLDTIQEQFNEKFLSLNLLKDRYKVNKRGIWDKEVLAIVNEHIPVNIIASGENFKKTGYNISVEEINKEKFFEICRFEIKKIQKEIKEKETQLSRYGQGLDCLKSRVDQVKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE41</accession>
    <name>A0A386PE41_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication protein DnaD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DnaD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07425</name>
        <name evidence="3" type="ORF">EI377_02115</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673790.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01094"/>
    <dbReference type="EnsemblBacteria" id="AYE34293">
        <property type="protein sequence ID" value="AYE34293"/>
        <property type="gene ID" value="CP523_07425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59687">
        <property type="protein sequence ID" value="QAS59687"/>
        <property type="gene ID" value="EI377_02115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017019">
        <property type="entry name" value="DNA_replication_prd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034829">
        <property type="entry name" value="DnaD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006343">
        <property type="entry name" value="DnaD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07261">
        <property type="entry name" value="DnaB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033722">
        <property type="entry name" value="DnaD_CA_C3587_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158499">
        <property type="entry name" value="SSF158499"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01446">
        <property type="entry name" value="DnaD_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaB_2" evidence="1">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DnaB_2" evidence="1">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="331" mass="38563" checksum="D49DD4A420C4A0C6" modified="2018-12-05" version="1">MSTFMLKSKALKFTPISNVFIEKYMPKARGEFIKVYLLMLKHNMSGEIGISSSILASSLNLLESDIINALNYWNDEGVIKLVPIDKMGNFEIDFVDLSIDTPASSNEINLLDELSDETNNGMLKDIERLLGRPLSPTEFTTYISWKKDYNFSSELILLIIEYCISRGKSNTRYIEKVAIAWHEMNIKTIEDAQNYIRKTEDKWGTYREILKFLGIRNTDIMKPQEDMLEKWTTTYNFSLEIIKKACDICSQRLNRPDFKYIDGILSSWNRDNLKTIKDIEEKESKFKNLAAKKNFNNTPNTKSNLKFNNFTPREYDYDSLEKKLLGWDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE92</accession>
    <name>A0A386PE92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dTDP-4-keto-6-deoxy-D-glucose epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06415</name>
        <name evidence="4" type="ORF">EI377_00890</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677418.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02159"/>
    <dbReference type="EnsemblBacteria" id="AYE34130">
        <property type="protein sequence ID" value="AYE34130"/>
        <property type="gene ID" value="CP523_06415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59497">
        <property type="protein sequence ID" value="QAS59497"/>
        <property type="gene ID" value="EI377_00890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="181" mass="20919" checksum="96960DF17925C223" modified="2018-12-05" version="1">MFRVKPLEVEGCFVITPSISMNNTCDLIKVFNDIQFNIYGLSTEFKEEYYAIAKPGAVRGMHFQSPPEAHDKLVTCIKGEIQDVIVDLRKHSKTFGKYAMVNLNESNKELVYIPKGCAHGYYIKGEKEALIFYKVTKPFIPEYRGGIHWSSLNIPWDFKGEIKVEEEDEKFPKFEDFDSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK1</accession>
    <name>A0A386PEK1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative septation protein SpoVG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoVG</name>
        <name evidence="5" type="ORF">CP523_08490</name>
        <name evidence="6" type="ORF">EI377_03240</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be involved in septation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SpoVG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674841.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01639"/>
    <dbReference type="EnsemblBacteria" id="AYE34463">
        <property type="protein sequence ID" value="AYE34463"/>
        <property type="gene ID" value="CP523_08490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59866">
        <property type="protein sequence ID" value="QAS59866"/>
        <property type="gene ID" value="EI377_03240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00819">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007170">
        <property type="entry name" value="SpoVG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036751">
        <property type="entry name" value="SpoVG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38429">
        <property type="entry name" value="PTHR38429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04026">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160537">
        <property type="entry name" value="SSF160537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="94" mass="10463" checksum="2448EBEBE10A030F" modified="2018-12-05" version="1">MTITDVRIRKIAAEGKMKAIVSVTFDNEFVVHDIKVIEGQNGLFIAMPSRKTPDGEFKDIAHPINTDTREKIQSSILAAYEKAVLEDDSEVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ4</accession>
    <name>A0A386PEQ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">FAD-linked oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03035</name>
        <name evidence="6" type="ORF">EI377_13535</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01770"/>
    <dbReference type="EnsemblBacteria" id="AYE33511">
        <property type="protein sequence ID" value="AYE33511"/>
        <property type="gene ID" value="CP523_03035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61677">
        <property type="protein sequence ID" value="QAS61677"/>
        <property type="gene ID" value="EI377_13535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="453" mass="52256" checksum="07E22C545758CFD6" modified="2018-12-05" version="1">MRKFDYSNLTGKVVTREDFSYEEDRKSWNRAIEKYPLVIIYCYNREDIINSIKWARDNFVPIRIRSGAHNYEGYSTGNDVAIIDISNMNDIDIDEKNNIVKIQGGVRNRELYEFLGERNYPFPGGGCPTVGVSGLVLGGGWGYSARLLGLASDNLIELELINYNGEKIIANKDKNEDLLWASMGGGGGNFGVVTSMTFNLPEKIKMATLINLDYKNVSMEENINIFEVWQEEFKTLDKRFNFKMGIYNSKEKGRGVRITGLFYGTNEEANIILSPFRNLSKISDFDLEYITVLEANRRIQDSHPPYEKYKSTGRFVYKDYTKEEIIDIVNLVKDREEGSIYAAVSFYGLGGVISNKDKVNTAFYYRDAKFIMGLQSVWEEAEYAPINREWVKEKFKYIKSITKGSFINFPIAELDNYEKEYYGENSIRLRTIKSKYDPEDVFNFPQSIKINND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER7</accession>
    <name>A0A386PER7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05320</name>
        <name evidence="3" type="ORF">EI377_15885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677996.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33937">
        <property type="protein sequence ID" value="AYE33937"/>
        <property type="gene ID" value="CP523_05320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62088">
        <property type="protein sequence ID" value="QAS62088"/>
        <property type="gene ID" value="EI377_15885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="279" mass="31824" checksum="CFAD3CAB24C7258D" modified="2018-12-05" version="1">MGIMDKVRELGEEIAKTVDESAIKENVKCATMIIKDTVEKGKKEIESKIEENRQRIDEEKKLLKDLEENTENNVADNFQLGVVTINTEKMLEFANLYSDKICSIRNSIKEPKLTFGKDSSEKSVSKILSSWDKFDELEGIDEANNEEVIIEVIELNKEEDTIFCYNGGRKCSVLLTTKNIYLKVKHPVHNLIYSSKISTGKLQKIKIINNETGNILTLNDVEVGLVDDDFAEGLIKYLDKVNLGIYEITIDDVIEELKKVKFVESKVVLDIINEIRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF48</accession>
    <name>A0A386PF48_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08315</name>
        <name evidence="4" type="ORF">EI377_03060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01604"/>
    <dbReference type="EnsemblBacteria" id="AYE34430">
        <property type="protein sequence ID" value="AYE34430"/>
        <property type="gene ID" value="CP523_08315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59833">
        <property type="protein sequence ID" value="QAS59833"/>
        <property type="gene ID" value="EI377_03060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="457" mass="53738" checksum="CAC86128F7906EF1" modified="2018-12-05" version="1">MAQINKLYRNFIILQEDERGYSNSNDKTLSGYSKIEAKGEKCKVSFYAQNLKVNDDYCIMLICNKKDSKKLINLGSIKVSEGGKAEVTKEYFVDNIAGVGISYDKISGAAIVKMKDGIPIFIMCGFMNGEQPSDNWKNYKIIKSEEIVAKGKLKMQSTKKEYEKDKCKEKQKEKKHEKEHEKESEKDKKKECKCKCKREDEIQESEYVEVESVEEIENVEEVENVEEVEVIDPTLNREENEEVKKTEEESKTNKDITEELKEEIRNEIKDEIKDEVRSEIKEELKEEVRREMAEEIKAKEERSKFDEYEAIVEEKSDVFEIRGSVGEYFEGIAIGFEHYRGFKEIKNCKWYKVQVNDLYEMCNMSNYNKYTVAYYPMLNYYPYIKKYGYFMLGYKCDKEGNLKYIIYGVPGKKDKNEQPYEGKTGFVTWISDEDKDSIGCWLMFYDFRNSTVVVPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF89</accession>
    <name>A0A386PF89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_01165</name>
        <name evidence="8" type="ORF">EI377_11665</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674398.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02285"/>
    <dbReference type="EnsemblBacteria" id="AYE33162">
        <property type="protein sequence ID" value="AYE33162"/>
        <property type="gene ID" value="CP523_01165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61332">
        <property type="protein sequence ID" value="QAS61332"/>
        <property type="gene ID" value="EI377_11665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="343" mass="38769" checksum="D2C433FF4C54F5F7" modified="2018-12-05" version="1">MKIYKKYKSLINKILLIAFTLLLIFIYFKVGTINTIVNIVFIGFIFAYTLNPLRNYISEKFNISKRISSIILIILIVSLVLLTLYIVLPTIFRESLNFGDMLDNIEKYINDLAIKLKINDVSFFQSIYTEINEEVNRYLSGFSSNFLENMMSVLENLVSFAIIPIVTYYFLVDGDLIYNKILLVLPTEKRVIAKKAIKNIDKILSRYIISQLLLSLIIGILTFIILMLIGVRFAFILAVLNGILNIIPYFGPIIGGIPAVIIALIDSPVKALWTIIGVFILQQIEGNILSPKITGDSTNMHPIIIIILLLIGEKMGGFLGMVLAVPIGVIIKVIYDDINDYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF91</accession>
    <name>A0A386PF91_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YhgE/Pip domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02095</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00547"/>
    <dbReference type="EnsemblBacteria" id="AYE33336">
        <property type="protein sequence ID" value="AYE33336"/>
        <property type="gene ID" value="CP523_02095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="630"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="559"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="725" mass="80618" checksum="BA146623D714B7C0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE2</accession>
    <name>A0A386PFE2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34775">
        <property type="protein sequence ID" value="AYE34775"/>
        <property type="gene ID" value="CP523_10375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038965">
        <property type="entry name" value="InsF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46889:SF1">
        <property type="entry name" value="PTHR46889:SF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13333">
        <property type="entry name" value="rve_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_21" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="173" mass="20736" checksum="0A3785D642C08F0E" modified="2018-12-05" version="1">MKGKIKQIFEENKGRYGSIRIEKVLNNKGININRKHVARLMRELKLCPKGTLYRYKYYNKKSNAIERPNLLNQMFQTDSKNKIWVRDITYIPTKKGTLYLAVFLDIYSRKVVGWSMESFYRTIKRELILDAKYQTLEQAQKEIFKYIELYYNTKRIHSSLGYILPAEFEKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF0</accession>
    <name>A0A386PFF0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06605</name>
        <name evidence="3" type="ORF">EI377_01095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02199"/>
    <dbReference type="EnsemblBacteria" id="AYE34167">
        <property type="protein sequence ID" value="AYE34167"/>
        <property type="gene ID" value="CP523_06605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59535">
        <property type="protein sequence ID" value="QAS59535"/>
        <property type="gene ID" value="EI377_01095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="449" mass="49669" checksum="2F1599C0E43B6FCE" modified="2018-12-05" version="1">MNKEYTDWFNELVKSYYDGNFDETIKKILSNSNKSPEETFSVISSLCGCNIKYDENYIYNLKKAITNYNVHQKIVEKLQNCFGKCSENIDEIPKCQLACPFDAIIDNKENNTKVIDNERCIDCGLCIDACDNGNFIDKVEFLPIMELIKNNTKVIAAVAPAISGQWGPNTTMDQMRAALINLGFTDMIEVAFAADMLTIKEAVEFNKHVKSSSDLMITSCCCPMWVGILKKVYKSLVKDLSPSVSPMVAAGRVIKKLNKDAKVVFIGPCIAKKAEAKEKDLSDAIDFVLTFQELKEIFNALDICPSSLQGVPSIEYASRGGRLYARTGGVSIAISEAVEELYPEKHKLFKAVQAEGVKNCKEVLAKAQEGSLDANFIEGMGCIGGCVGGPKILVSKEDGKKAVDDFAYNSSIKIATHSNILDNILNDLNITSLDDFKSPEKIHILERDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG8</accession>
    <name>A0A386PFG8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_04370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00404"/>
    <dbReference type="EnsemblBacteria" id="AYE33761">
        <property type="protein sequence ID" value="AYE33761"/>
        <property type="gene ID" value="CP523_04370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="248"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="460" mass="54167" checksum="E2DD8875AF34BC8C" modified="2018-12-05" version="1">MDINLKRNKKPISLQTLILNKLFLYILVSILSLILFNWIIKEMYTTSIIKSNLYEPLDVDLENYEDISQEYLNDNHSSIEVIDKNLNIIYSEGFNKETKSKYTLLEFTDLLNNMDEYKNVYYNILQKDNGNEVTVVLIQHFNSNTLSKFNRLFRIYVITLIIGTFLIFLTAFLMFVRSIYRYIRKNFLFIQKNIEKTPYDKSRVDTSKINLLEAKNTIDCYNTMLDEMDSIKNEKDRLENQSRRLISNLSHDLKSPITTIKGYSEVLATEDLPVKEQKEYLSYINQSASDLNDLISLLFEQVKFQYCDYKLNLEQGDINNFLRDIAANYYMIFDKRGFNVNINIEETPHYINFDKVNIKRAFVNILENCLSHNTTPTNVEIESLTKKNKYIIRFKDNGIGISEEFKDNIFEPFYQGDSSRSTNHSGLGLYVTKQILEKHNATIIVTSDENFKTIFEIKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM0</accession>
    <name>A0A386PFM0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10810</name>
        <name evidence="4" type="ORF">EI377_05595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677601.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34855">
        <property type="protein sequence ID" value="AYE34855"/>
        <property type="gene ID" value="CP523_10810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60249">
        <property type="protein sequence ID" value="QAS60249"/>
        <property type="gene ID" value="EI377_05595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788311" evidence="2">
        <location>
            <begin position="31"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="23867" checksum="9FEDA980849495DD" modified="2018-12-05" version="1">MIRKTLSIILSSFMLITLVSCNSPKSNNEANSNNPSTEEKIPEKPKEEENTPEPIVSFDAFGKTYTSSKDIKTIEKSTDIYNIEYPYVAGEFKEIDFAKDLLTEYVNENPEVYTHLVSFDSSNKNGITPITEVDKTNLQADLESLRNQMHMSEGEAMALSLDTVTFEGPSNKTNTGITLKIRVAISKVGAYAVPFNSYTVTLFEQDGKLVAHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM2</accession>
    <name>A0A386PFM2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09220</name>
        <name evidence="2" type="ORF">EI377_03965</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678329.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34590">
        <property type="protein sequence ID" value="AYE34590"/>
        <property type="gene ID" value="CP523_09220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59990">
        <property type="protein sequence ID" value="QAS59990"/>
        <property type="gene ID" value="EI377_03965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="99" mass="11680" checksum="EE559B2D1697AB8A" modified="2018-12-05" version="1">MLIKCINNSLCTTLTLNKEYPVIEEGPNYYVIIDDVLEEITTKKERFIVVEDNDLSKKTKATINELNYQLENDFPDIRDFKTRKNSKGEIKEIVIKFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV0</accession>
    <name>A0A386PFV0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">[FeFe] hydrogenase H-cluster radical SAM maturase HydG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hydG</name>
        <name evidence="7" type="ORF">CP523_03270</name>
        <name evidence="8" type="ORF">EI377_13785</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677230.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02130"/>
    <dbReference type="EnsemblBacteria" id="AYE33556">
        <property type="protein sequence ID" value="AYE33556"/>
        <property type="gene ID" value="CP523_03270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61719">
        <property type="protein sequence ID" value="QAS61719"/>
        <property type="gene ID" value="EI377_13785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044271">
        <property type="term" value="P:cellular nitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018130">
        <property type="term" value="P:heterocycle biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042364">
        <property type="term" value="P:water-soluble vitamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024007">
        <property type="entry name" value="FeFe-hyd_mat_HydG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF2">
        <property type="entry name" value="PTHR43583:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00319">
        <property type="entry name" value="Fe_hydrogenase_maturase_(HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03955">
        <property type="entry name" value="rSAM_HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="BATS" evidence="6">
        <location>
            <begin position="261"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="457" mass="52635" checksum="DD9A0BFD07282545" modified="2018-12-05" version="1">MFIDHEYIERILEEAKSATKDDIQNVLERAKERKGLSHEDIAILLQADDENLKEMYKIAGDIKNSIYGKRVVIFAPLYVSNYCVNNCVYCGYQHCNEFERRRLTQEEVKEEVRILEKMGHKRLALELGEDPVNAPIEYVLECLDTIYKTQNSNGEIRRVNVNIAATTVENYKKLKKANIGTYILFQETYHKPTYEKMHPKSIKGDYTYHLTAFDRAMEAGIDDVGGGVLFGLSDPKFEVLALMIHNEHLEEKFGVGFHTVSFPRLKKAKGMDLESFPNLLDDNMFKRIVAITRIAIPFTGIIMSTRETEEMRRELLKYGVSQVSAGSSTGVGGYKEREEGREVLQFKTSDERTPLEVLKALLDDGYIPSYCTACYRKGRTGERFMKLAKSGNIQYVCEPNAMMTLMEFALDYGDKEILEKSEKLVRNEIKNIKRDDIRELVKNNIEKLKKGERDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV1</accession>
    <name>A0A386PFV1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore protease YyaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yyaC</name>
        <name evidence="1" type="ORF">CP523_07600</name>
        <name evidence="2" type="ORF">EI377_02290</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673838.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01129"/>
    <dbReference type="EnsemblBacteria" id="AYE34317">
        <property type="protein sequence ID" value="AYE34317"/>
        <property type="gene ID" value="CP523_07600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59711">
        <property type="protein sequence ID" value="QAS59711"/>
        <property type="gene ID" value="EI377_02290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009665">
        <property type="entry name" value="DUF1256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06866">
        <property type="entry name" value="DUF1256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02841">
        <property type="entry name" value="spore_YyaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="198" mass="22097" checksum="9D4533CC966B66F3" modified="2018-12-05" version="1">MSKCFSVTACSPNSYVEVRDYLCNKLNKLIKENKDIIFICIGTDRSTGDSLGPLVGYKLKFISRKNIHIYGSLENPIHANNVENTFKKIKSTFNNPYIIAIDSCLGDIHNIGKVFIEDKPLRPGLALDKNLPPIGNMSIRGVVNIAGNLEFMVLQNTRLCTVMTLADCISNGIFHFILKSLGNNTKYLNTSLDSMKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY5</accession>
    <name>A0A386PFY5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroB</name>
        <name evidence="10" type="ORF">CP523_11380</name>
        <name evidence="11" type="ORF">EI377_06195</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02832"/>
    <dbReference type="EnsemblBacteria" id="AYE34965">
        <property type="protein sequence ID" value="AYE34965"/>
        <property type="gene ID" value="CP523_11380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60358">
        <property type="protein sequence ID" value="QAS60358"/>
        <property type="gene ID" value="EI377_06195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11380"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="352" mass="39865" checksum="79C268A8C0AD8123" modified="2018-12-05" version="1">MNLTVDLKDRSYEIVIEKGLIDYIGLEIKRVFKGKKVVILTDKNVDKFYGEKVKSSLIKESYEVKKVVLEAGEGTKSFLTLPKVYNELLDFKVTRSDLLLTLGGGVIGDLGGFIASTYLRGIDFIQCPTSLLAQVDSSVGGKVGVDLDRGKNLVGSFYHPKKVIIDPNVLNTLEERFFKDGMGEVIKYGCIKDKGFFEKLGSYKDKKEVINNIEYIIHNCCTIKKEVVEKDERDKGERMLLNFGHTLGHAIEQYYKYQKYTHGEGVAIGMYEIIKLSEEKGISKRGMSEEIKNILIKYDLPYELDININDILEAISLDKKNLGKTLNLILLKDIGEAFIYKTDTKFFSNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG02</accession>
    <name>A0A386PG02_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prephenate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase/arogenate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11420</name>
        <name evidence="4" type="ORF">EI377_06235</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673279.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02841"/>
    <dbReference type="EnsemblBacteria" id="AYE34973">
        <property type="protein sequence ID" value="AYE34973"/>
        <property type="gene ID" value="CP523_11420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60366">
        <property type="protein sequence ID" value="QAS60366"/>
        <property type="gene ID" value="EI377_06235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11420"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="277" mass="31376" checksum="5C7F4226BC224125" modified="2018-12-05" version="1">MNIVIVGLGVIGGSYAMALKNAGYKKIFGVDSNMETLKKAKELELIKEGYIYGSYIIKKADLIILSIYPKLVKTFIEENRNNFKKGAVITDATGIKELFIKDVLDILPKDVDFIFGHPMAGREKKGIDYASSEVFNGANYLITVIEKNKEENIALVEKIAYNIGFKRVKRITSKYHDEIISFTSQLPHAIAVALINSDKESRDTGSFIGDSYRDLTRIANINEDLWSELFLGNKLNLIKVIDEFSSELEKIKKCLIEDDSEMLKSLFIKSTKRRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG25</accession>
    <name>A0A386PG25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04795</name>
        <name evidence="3" type="ORF">EI377_15305</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675787.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33838">
        <property type="protein sequence ID" value="AYE33838"/>
        <property type="gene ID" value="CP523_04795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61984">
        <property type="protein sequence ID" value="QAS61984"/>
        <property type="gene ID" value="EI377_15305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="19251" checksum="4462DC770B921E7D" modified="2018-12-05" version="1">MTFNIICILSPIIINVYDVKKKSEFYSDASMLILKILMTIIMILFDIYIFFYLLPKVIMKIFKKLSIKHYKNKPIFSAEKTVLVKDDSIEVTYDNKKLIIPLKENIFAHEFKGNIIIASIFLKNKINKVYPVIIPVTAFENEENKDEFIRNINEKGCFIGTKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC1</accession>
    <name>A0A386PGC1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12075</name>
        <name evidence="3" type="ORF">EI377_06905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673497.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02972"/>
    <dbReference type="EnsemblBacteria" id="AYE35093">
        <property type="protein sequence ID" value="AYE35093"/>
        <property type="gene ID" value="CP523_12075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60486">
        <property type="protein sequence ID" value="QAS60486"/>
        <property type="gene ID" value="EI377_06905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035168">
        <property type="entry name" value="DUF5317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17248">
        <property type="entry name" value="DUF5317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="181" mass="21018" checksum="F1C80500F662CC33" modified="2018-12-05" version="1">MIETIIIALIFAKSKGLKIKDIFKNWTIYPIILMEIIYIFVQINIFNANYSVIKYSEILKIIYFCSYIPLILKYNQYLSAIIGSFFMIIGGFLNDIAIRANGGKMPVFPTLSYFTGYIKSDSFIRVNDIHILGDCTTKFKFLTDIFDLGYSVLSIGDIFIRFYVFIIIYKSIKYINKVDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE3</accession>
    <name>A0A386PGE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12235</name>
        <name evidence="6" type="ORF">EI377_07055</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03002"/>
    <dbReference type="EnsemblBacteria" id="AYE35123">
        <property type="protein sequence ID" value="AYE35123"/>
        <property type="gene ID" value="CP523_12235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60514">
        <property type="protein sequence ID" value="QAS60514"/>
        <property type="gene ID" value="EI377_07055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051409">
        <property type="term" value="P:response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023950">
        <property type="entry name" value="Hmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="PTHR43396:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="32713" checksum="62E951AE5B15075E" modified="2018-12-05" version="1">MDTLKNVYENSFNSIDEIMKKYGNTNLTQEDYPKEWKGFRELVLVDRVQECEDIVSFYFKSKDGKKLINHKPGQYLPIKIKTNDPKYKEEIRTYSLSMKPNEHIYRISVKKVLGGLISTYLHENLKVGDIVNAMMPTGIFTLKDADKDRNIVLISAGIGITPVLSMLYEGVNTFENIYFIQAVQNSKIQPFGYDVEKIREGSSLKSYVFYSNPLDEDIQGKDYDFTGYINKEWIKDNLPLDAEFYFCGPPPFMKILNKSLKELGVKKENINFEFFGKPEDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE5</accession>
    <name>A0A386PGE5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05395</name>
        <name evidence="2" type="ORF">EI377_15955</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677978.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02590"/>
    <dbReference type="EnsemblBacteria" id="AYE33948">
        <property type="protein sequence ID" value="AYE33948"/>
        <property type="gene ID" value="CP523_05395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62099">
        <property type="protein sequence ID" value="QAS62099"/>
        <property type="gene ID" value="EI377_15955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="10171" checksum="94F75AD4C083E6D4" modified="2018-12-05" version="1">MSVGIFISISNAILGLIEDMSWNLNFLMEELAKNKEYVSELEDFFKLKECEGAIDKPSEEKINLKRLEFKNVCLIIQEQIIIYFVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG0</accession>
    <name>A0A386PGG0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_06310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02422"/>
    <dbReference type="EnsemblBacteria" id="AYE34111">
        <property type="protein sequence ID" value="AYE34111"/>
        <property type="gene ID" value="CP523_06310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07475">
        <property type="entry name" value="Peptidases_S8_C5a_Peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034216">
        <property type="entry name" value="C5a_Peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="Fn3_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022038">
        <property type="entry name" value="Ig-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12245">
        <property type="entry name" value="Big_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13750">
        <property type="entry name" value="Big_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017411776" evidence="9">
        <location>
            <begin position="37"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1528"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="10">
        <location>
            <begin position="182"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="11">
        <location>
            <begin position="427"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="fn3_5" evidence="12">
        <location>
            <begin position="662"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="14">
        <location>
            <begin position="912"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="13">
        <location>
            <begin position="1326"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like_bact" evidence="13">
        <location>
            <begin position="1394"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1556" mass="172300" checksum="CCC80135266939B9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH3</accession>
    <name>A0A386PGH3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03740</name>
        <name evidence="6" type="ORF">EI377_14270</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01462"/>
    <dbReference type="EnsemblBacteria" id="AYE33642">
        <property type="protein sequence ID" value="AYE33642"/>
        <property type="gene ID" value="CP523_03740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61806">
        <property type="protein sequence ID" value="QAS61806"/>
        <property type="gene ID" value="EI377_14270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03740"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="180"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="313" mass="34494" checksum="7C2BA6F8F477112D" modified="2018-12-05" version="1">MKIAIAGAGAMGSRFGLMLHKTGNEVILIDKWADHVNKIKEVGLKANFNGEDVVEKIPAFFPNEMEEYTDNIDTVILFTKAMQLDDMLQSIKSILSKDTKVLCLLNGLGHEDTVKKYVAEENILLGNTMWTAGLIGPGEVKLFGNGEVELQNVYPGGKEAALEVVSVLSEAGLNAKYSENVKYSIWRKACVNGTLNGTCTILDSNIASFGATKATDKIIRTIINEFADVAEKEGIILDREEIVNHVKTTFDPNGVGKHYPSMHQDLIKNNRLTEIDYINGAVCKKGEKYNVPTPYCQFLTLLVHAKEEILIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI3</accession>
    <name>A0A386PGI3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ORF">CP523_01830</name>
        <name evidence="10" type="ORF">EI377_12350</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677292.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02385"/>
    <dbReference type="EnsemblBacteria" id="AYE33289">
        <property type="protein sequence ID" value="AYE33289"/>
        <property type="gene ID" value="CP523_01830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61460">
        <property type="protein sequence ID" value="QAS61460"/>
        <property type="gene ID" value="EI377_12350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01830"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutaminase activity" evidence="5">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="473"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="634" mass="71864" checksum="F639F2B2844C8EA9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN7</accession>
    <name>A0A386PGN7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">thiE</name>
        <name evidence="12" type="ORF">CP523_12880</name>
        <name evidence="13" type="ORF">EI377_07760</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678235.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03035"/>
    <dbReference type="EnsemblBacteria" id="AYE35245">
        <property type="protein sequence ID" value="AYE35245"/>
        <property type="gene ID" value="CP523_12880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60640">
        <property type="protein sequence ID" value="QAS60640"/>
        <property type="gene ID" value="EI377_07760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12880"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="203" mass="22420" checksum="1876A86960EC104B" modified="2018-12-05" version="1">MESLKLYLVTDGDILEGRDFYKSIEDALKGGVTMLQLREKDCSGKEFLEKAIKLRELTRNYNVKFIINDRVDIALLCDADGVHVGQSDIPASEVRKLIGDNKILGVSARTLEEAKKAKEHGADYLGVGAMFGTNTKLDAKHVSIDTLKEIKSKVKIPIVAIGGLNLNNIQDIKECKIEGYAVVSAILASNDIKAECEKWINRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ2</accession>
    <name>A0A386PGQ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome C biogenesis protein CcsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_04155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02753"/>
    <dbReference type="EnsemblBacteria" id="AYE33722">
        <property type="protein sequence ID" value="AYE33722"/>
        <property type="gene ID" value="CP523_04155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="261"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="405" mass="45405" checksum="2C6F4EE4BA7D5990" modified="2018-12-05" version="1">MENINFLVVFIEGVLSIFSPCILPILPIYLSMLSNSSVDSMKENKFKSSVLLKNTIFFTLGISTTFFILGSSINALTSFFNTNKNMIMIIGGFIIIFMGLFYLGIIQSNILSREKRFSVKSKNMTSLSAFLLGFTFSFGWTPCIGPILASVIIMASSSKNALASNLLILVYTIGFIAPFIIVALFYSKLFKKFDKVKKHIVLIKQISGIIILVAGLIMIINGFVGINKELGTKNQSQNNISSSQNPNSQSNGNNYDDKSGEEHKVKPIDFTLSDQYGNKHSLSEYKGKTIFLNFWATWCPPCRAEMPYIDELYNEYNQNKDDVVILGVASPNLGREGSEDHIKKFLDDEGHKFPIVFDENGAMVYQYGINAFPSTFIIDKEGYIKRYVPGGMNKDTMKKLIESER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ3</accession>
    <name>A0A386PGQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12990</name>
        <name evidence="6" type="ORF">EI377_07865</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677808.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02538"/>
    <dbReference type="EnsemblBacteria" id="AYE35265">
        <property type="protein sequence ID" value="AYE35265"/>
        <property type="gene ID" value="CP523_12990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60660">
        <property type="protein sequence ID" value="QAS60660"/>
        <property type="gene ID" value="EI377_07865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="28392" checksum="FC87F884C01B6FD4" modified="2018-12-05" version="1">MLKIKNLSCGYNGIDVVKDISFNVKRGQNICIVGPNGCGKSTLLKAISNLIESKGDISLDNIKISELNRKDLATKIALMTQTTNIQFPYTVYETVALGRYAHLKGFFSNLTKEDENIVLNCMDMVGLLDIKDKVITELSGGQMQRVFLARAFAQNPEVILLDEPTNHLDLRYQIDILNYLSKWVKENNKIVIAVLHDLNLVQRFGDNVVMLKSGEVKSIGKPCDVFKDDFLIDVYGINIRKFMLETLEKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS8</accession>
    <name>A0A386PGS8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07200</name>
        <name evidence="2" type="ORF">EI377_01955</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673730.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01057"/>
    <dbReference type="EnsemblBacteria" id="AYE34251">
        <property type="protein sequence ID" value="AYE34251"/>
        <property type="gene ID" value="CP523_07200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59657">
        <property type="protein sequence ID" value="QAS59657"/>
        <property type="gene ID" value="EI377_01955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="24417" checksum="FDC3C693AB21D423" modified="2018-12-05" version="1">MKKVAKIQKPKFIDDLEIINDIYEEIIIQEKIQNKLIENITIEDKNDIGLTIDSCVFKNVIFNNCAFKNVDLLDSKFENCDLSNIDFTGGLINRVEFINCKLVGARFDEASLKDVLFENVSAKYSNFSFARFKGINIVESNFQDSTFQEIKHEKMYLKYVDLTNAYFNKTSLSKINLTTCDISGIDIQIKDLEGAIVTPVQGLDLTRLMGLVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV4</accession>
    <name>A0A386PGV4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosine-specific methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_07365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34281">
        <property type="protein sequence ID" value="AYE34281"/>
        <property type="gene ID" value="CP523_07365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="414" mass="47076" checksum="88D3DEE8EFE879C0" modified="2018-12-05" version="1">MENNEKVNIWHNSIPVEKSSYINENNIIIYNEENFKLEKDKPTMIDLFCGAGGFSVGCELAGFQSVLGTDWFEPALETWKYNHPNAISILGDIKNITPDLLVETLQKAGVKKVNLITGGVPCQGFSRANRKHNDEDERNYLFRDYMKIAEAFQPDYLIVENVSGMKTTAGGKFVEEILASMEELGYNSTVKLLNAADYGVPQIRKRIIFVGIKKGRGLAEIFNYPEPQFKEKDSQTGLLDSKELPQYRTVYDAISDLPPIESNENSDKYISKPLTEYQKIMRGMDDNINFTKSEELFNHVAPKHPQDTIDKIRSTIPGMPMYEKFKQRIRLTWEKPSPTQLAGGIRPQFQFGHPSIARGLTIRERARIQSFPDSYKFLGGTVQERVQTGNAVPPLMIYAVAKEIIKDLNKVYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY6</accession>
    <name>A0A386PGY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar hook-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flgL</name>
        <name evidence="5" type="ORF">CP523_02700</name>
        <name evidence="6" type="ORF">EI377_13225</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676950.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00946"/>
    <dbReference type="EnsemblBacteria" id="AYE33449">
        <property type="protein sequence ID" value="AYE33449"/>
        <property type="gene ID" value="CP523_02700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61620">
        <property type="protein sequence ID" value="QAS61620"/>
        <property type="gene ID" value="EI377_13225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="4">
        <location>
            <begin position="246"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="330" mass="37163" checksum="9235CBE339B99AFF" modified="2018-12-05" version="1">MRVTNSMMSTSFLRDLGRNQENLKTLNNQLTSGKEIRRPSDNPFKVARAMQLHSDIGVNKQYNENIKDTSNWLETTDVALEQLNNSFQRIRELMVSSGNASYGPDEKRAIKDEINEKTNEISQILNTSFDGKYLFGGTKVNSKPVNIMQDPVTSNNLLNLSGRDGEFLRLDSKDIDIQNQISMIGTKLKVEITQGVTMDYSVSATDLLVFKGKKDDINVMDLLSEITNNLDSNDPVKLSRIINENLKAMDEVMANINKVRAEVGAKMNRMESAQDQNEEQNFSIKDILSQTEDIDFAEKTMEVAVAQSVYMASLQTSARILQPSLLDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY7</accession>
    <name>A0A386PGY7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13405</name>
        <name evidence="3" type="ORF">EI377_08295</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677538.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35343">
        <property type="protein sequence ID" value="AYE35343"/>
        <property type="gene ID" value="CP523_13405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60734">
        <property type="protein sequence ID" value="QAS60734"/>
        <property type="gene ID" value="EI377_08295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="153" mass="17480" checksum="E5B2BB919CACD078" modified="2018-12-05" version="1">MNFNGFNNFEEFFRNFEYKNNNGCESNNNLGCNDINGGFQDLNPEFFIIIGELIGNVMAGRLPFNVQNAVGNWLQLVGQAILTYNSQQQYFESGPGNYYNLSNKNTSNPNCPNNNNTDTSNNSKEIDKLKDNIDKLTKEIKELKKDIEIMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH23</accession>
    <name>A0A386PH23_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_07890</name>
        <name evidence="9" type="ORF">EI377_02580</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675865.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00681"/>
    <dbReference type="EnsemblBacteria" id="AYE34351">
        <property type="protein sequence ID" value="AYE34351"/>
        <property type="gene ID" value="CP523_07890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59748">
        <property type="protein sequence ID" value="QAS59748"/>
        <property type="gene ID" value="EI377_02580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="299"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="452" mass="51705" checksum="CB1A1F97030D708F" modified="2018-12-05" version="1">MNISIPNDVQLIIDTFYNNGYKAFMVGGCVRDSILSCNPKDYDITTSALPEETINLFNKTVPTGIKHGTITVLINDESYEVTTFRSDGEYNDNRRPDSVTFVRNIKDDLSRRDFTINALAYNKKEGLMDYFNGLNDLQNKIIKCVGDPNKRFNEDALRMLRAIRFSCQLDFQIDYPTYNSIRKNYKLINNISSERIRDELCKILISNNPSKGLELLKDTGILQIILPEIYELIEYTPNCNNHNRDVFKHTLKVIDNTENNLLLRLAALFHDVGKLNTMTLLENGHCYFPGHSCESATMTKKILSRLSFDNLTIKRVCSIINEHLVLNVKYLPTDGEIKRLINKVGSNNMSLLFSLQRADTKALWNPQPFLDKIDFMEYRVNLILENNEPLTVKDLAINGKTIAEKLNLNPGKIIGEILNHLLDEVLDDSSLNNEDILLNKSKSYLESKHPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH33</accession>
    <name>A0A386PH33_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Magnesium transporter CorA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_08730</name>
        <name evidence="8" type="ORF">EI377_03480</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678055.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34494">
        <property type="protein sequence ID" value="AYE34494"/>
        <property type="gene ID" value="CP523_08730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59896">
        <property type="protein sequence ID" value="QAS59896"/>
        <property type="gene ID" value="EI377_03480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="315" mass="35982" checksum="956B7364C82BBDC9" modified="2018-12-05" version="1">MIQIYKSRSEQDPSLKILDNLEQGCWINIIAPSDEELILISKKTGVPLSFLKAPLDDEETSRIDIEDGCVLVVVDIPFTEMEDNSLTYDTYPLAIIHTEKQLITVCLKNSRILTDFINGKVKSFYSFKKSRFILQILNKISTYYLLYLRQIDKKSLMIEKRLHKSMKNRELIQLHSLEKSLVYFSTSLKANEITLEKMLKLEIMQKYEDDKDVLEDVIIENKQAIEMTEIYSNILASTMDFFASVISNNLNIVMKILASVTILMAIPTVIGGIFGMNFVEMPLLKNPAGFNITMIITAVLTGVTAFILYKKGMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA1</accession>
    <name>A0A386PHA1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09090</name>
        <name evidence="2" type="ORF">EI377_03835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00257"/>
    <dbReference type="EnsemblBacteria" id="AYE34564">
        <property type="protein sequence ID" value="AYE34564"/>
        <property type="gene ID" value="CP523_09090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59964">
        <property type="protein sequence ID" value="QAS59964"/>
        <property type="gene ID" value="EI377_03835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06088">
        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="103" mass="11532" checksum="A910B8E3DF70CA62" modified="2018-12-05" version="1">MAKVIIEVKSLQNNDLIGKVILSQAGRDKNHLYVIIEQISEAYVLLSNGSTKTVQMPKKKKLKHFTVLGDVNDEIKASIISKDRGTDLKIKRFLKLKGIVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC9</accession>
    <name>A0A386PHC9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Foldase protein PrsA</fullName>
            <ecNumber evidence="11">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">prsA</name>
        <name evidence="15" type="ORF">CP523_08530</name>
        <name evidence="16" type="ORF">EI377_03280</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the PrsA family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674865.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01647"/>
    <dbReference type="EnsemblBacteria" id="AYE34471">
        <property type="protein sequence ID" value="AYE34471"/>
        <property type="gene ID" value="CP523_08530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59873">
        <property type="protein sequence ID" value="QAS59873"/>
        <property type="gene ID" value="EI377_03280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01145">
        <property type="entry name" value="Foldase_PrsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023059">
        <property type="entry name" value="Foldase_PrsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6 11 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362957" description="Foldase protein PrsA" evidence="13">
        <location>
            <begin position="29"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="14">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="325" mass="37224" checksum="BA60B37360CCD7FA" modified="2018-12-05" version="1">MNKIKKVLATAMVGTLAFSVVGCKMIQKTPEAIQNTVIAKVGDEKITKGDIDKELKSYLDQFAAQYGDNYEEDPKLKEVLHQYRVNMMNTLINEKILLKKAKDLNLIPEQAELDKEIQSRIDQLKTTYGTEENFQKVLEASGHTDETFKKFIEEQVIAQKATEYIFKDINISDEDVKAEYEKNKENYGEANVSHILIADENKAKEIRERAANGEDFAELAKEFSEDPGSKDKGGDYGVIPYNSDKYVKEFVDGFKTLKEGEISQPVKSQYGYHIIKATNVKNYGFDDVKDEIKSELETAKKKEAYNKTMEEWKNEIKVKTYEDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF3</accession>
    <name>A0A386PHF3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glnS</name>
        <name evidence="12" type="ORF">CP523_12800</name>
        <name evidence="13" type="ORF">EI377_07675</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678191.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02797"/>
    <dbReference type="EnsemblBacteria" id="AYE35230">
        <property type="protein sequence ID" value="AYE35230"/>
        <property type="gene ID" value="CP523_12800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60625">
        <property type="protein sequence ID" value="QAS60625"/>
        <property type="gene ID" value="EI377_07675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="11">
        <location>
            <begin position="338"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="554" mass="64051" checksum="DDC12BFDA10808CB" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG5</accession>
    <name>A0A386PHG5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_12855</name>
        <name evidence="11" type="ORF">EI377_07725</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678248.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03040"/>
    <dbReference type="EnsemblBacteria" id="AYE35240">
        <property type="protein sequence ID" value="AYE35240"/>
        <property type="gene ID" value="CP523_12855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60634">
        <property type="protein sequence ID" value="QAS60634"/>
        <property type="gene ID" value="EI377_07725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="210"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="505"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="539"/>
            <end position="546"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="750" mass="82936" checksum="536E9130B4106364" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK3</accession>
    <name>A0A386PHK3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PTS lactose/cellobiose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06000</name>
        <name evidence="8" type="ORF">EI377_00480</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per trimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675071.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01902"/>
    <dbReference type="EnsemblBacteria" id="AYE34052">
        <property type="protein sequence ID" value="AYE34052"/>
        <property type="gene ID" value="CP523_06000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59424">
        <property type="protein sequence ID" value="QAS59424"/>
        <property type="gene ID" value="EI377_00480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00215">
        <property type="entry name" value="PTS_IIA_lac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34382">
        <property type="entry name" value="PTHR34382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000699">
        <property type="entry name" value="PTS_IILac_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared between all trimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="105" mass="11686" checksum="6F4BD22346BD5A9D" modified="2018-12-05" version="1">MKENMEMIIFEIINHGGTAKGLAYEALMAAEKGEFDKAEELLKEADVSLAEAHKVQTDIIQAEARGEKTEVSVLFVHAQDHLMTAIEAKTLIEHIIKLHKKIASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL0</accession>
    <name>A0A386PHL0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">CP523_09025</name>
        <name evidence="7" type="ORF">EI377_03770</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876949.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00245"/>
    <dbReference type="EnsemblBacteria" id="AYE34551">
        <property type="protein sequence ID" value="AYE34551"/>
        <property type="gene ID" value="CP523_09025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59951">
        <property type="protein sequence ID" value="QAS59951"/>
        <property type="gene ID" value="EI377_03770"/>
    </dbReference>
    <dbReference type="GeneID" id="66300464"/>
    <dbReference type="KEGG" id="csep:CP523_09025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="122" mass="13247" checksum="787DB8D96D26FBBC" modified="2018-12-05" version="1">MIQQQTLLKVADNSGAKEIMCIRVLGGSKRKFGNIGDIIVASVKSATPGGVVKKGDVVKAVIVRSVRGLRRADGSYIKFDENAAVIIKDDKQPRGTRIFGPVARELRDKEFNKILSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL4</accession>
    <name>A0A386PHL4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_06230</name>
        <name evidence="11" type="ORF">EI377_00705</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34096">
        <property type="protein sequence ID" value="AYE34096"/>
        <property type="gene ID" value="CP523_06230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59463">
        <property type="protein sequence ID" value="QAS59463"/>
        <property type="gene ID" value="EI377_00705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="310"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="405" mass="45457" checksum="CC75CBC788807894" modified="2018-12-05" version="1">MIRYSIKSLTNKKTISILFSIAVCIAVSISKLAINISSQIEEGFYQADKKYDIIIGAKGSKTQLIMSSLFFSDDPLGQIDKDYLDEISKKYKVNKIVPLAMADSYKGNRVIGTTIDLLDNYNFEKGNIFSKDFDIVIGSNIAERYNLSIGDKLITSHGTSEMAEEHHNSPYTVTGILKKTNTSYDNTCFTTVGSVWNAHKDHHHEEEDKDEHQDEHDDEHEHIDGEKHEHHMGYTALLIKTGNLAIANDIEISLKEDLKVQAINTTKVLRSLVGNIDMSKQVALLLCGIIVVLAVILTCVMSFFMLVNSKKDIEILKFLGMKKGKIFTYIISQIVMLIVISIGISVIINSWVLSIANNISSKLGIILDVSKKYPQEFYITLVYIIIIIVSTLIYTYVLTKGEDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN5</accession>
    <name>A0A386PHN5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">whiA</name>
        <name evidence="6" type="ORF">CP523_06345</name>
        <name evidence="7" type="ORF">EI377_00815</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677776.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02428"/>
    <dbReference type="EnsemblBacteria" id="AYE34116">
        <property type="protein sequence ID" value="AYE34116"/>
        <property type="gene ID" value="CP523_06345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59482">
        <property type="protein sequence ID" value="QAS59482"/>
        <property type="gene ID" value="EI377_00815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="5">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="316" mass="35695" checksum="635DCA3C5B0C9C4E" modified="2018-12-05" version="1">MSFSSKVKGEICRYSELTKETALAEISAIMKVSGTISFSGLGLAFRITTENPASARHIFSLLKEHFDIHSKLMVKKSNSLKKNNIYMVLIEEAMGVRDLLRDTGILKEVDGVLTLDYRIDEEMVKTDELKRAYVRGAFIGGGSISNPEKTYHLEFVTHSEEYANDLCKLINTFGLKSKVIQRKNSHIIYIKEGEQISNLLSILGAHTSLLELENIRIMKEMRNNVNRLVNCETANLSKTVNAAVRQVESIKLIQKEIGLQRLPKNLREIAELRLSYPDESLKELGEMLDPPVGKSGVNHRLRKIEKIAEEVRSGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP0</accession>
    <name>A0A386PHP0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase CwlD</fullName>
            <ecNumber evidence="4">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cwlD</name>
        <name evidence="3" type="ORF">CP523_09175</name>
        <name evidence="4" type="ORF">EI377_03920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678349.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03063"/>
    <dbReference type="EnsemblBacteria" id="AYE34581">
        <property type="protein sequence ID" value="AYE34581"/>
        <property type="gene ID" value="CP523_09175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59981">
        <property type="protein sequence ID" value="QAS59981"/>
        <property type="gene ID" value="EI377_03920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014234">
        <property type="entry name" value="Spore_CwlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02883">
        <property type="entry name" value="spore_cwlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788332" evidence="1">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="25506" checksum="9BEF64CE9C585265" modified="2018-12-05" version="1">MKVLKKISLLLVIALLISIPININAEANNKEKVILIDPGHGGFDGGAQSKSGTIEKDINLSISLKLKENLEKKGYKVEITRSDDNGLNEKGATIREKKREDLKRRCELKKETNCDIFVSIHQNMFPQSKCYGAQVWYSSNDISKSLANSIQDSLKETVKDNNKRVAKPAGESYLILRDKYEGASVLVECGFLSNPEEENKLKSEEHQNALVEGISTGIDKYFESGDSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ1</accession>
    <name>A0A386PHQ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15005</name>
        <name evidence="2" type="ORF">EI377_09960</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676042.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01283"/>
    <dbReference type="EnsemblBacteria" id="AYE35635">
        <property type="protein sequence ID" value="AYE35635"/>
        <property type="gene ID" value="CP523_15005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61022">
        <property type="protein sequence ID" value="QAS61022"/>
        <property type="gene ID" value="EI377_09960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="120" mass="14270" checksum="EB22684A0B4C03CE" modified="2018-12-05" version="1">MQQIKSDIQLFKGKLNLVQDKEYKDLFNNISSILDALSDKVEEVLVKQEYLEENVQYMDEDLTDLQEELFEEVSFDELDDFEDEYIEINCVNCNKPMFIEKEILEKNKTVPCPFCKKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS0</accession>
    <name>A0A386PHS0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02722"/>
    <dbReference type="EnsemblBacteria" id="AYE34611">
        <property type="protein sequence ID" value="AYE34611"/>
        <property type="gene ID" value="CP523_09325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="59" mass="6811" checksum="29B9F84837DBCCFA" modified="2018-12-05" version="1">MKNKENGYWILELNEESIEHALTGTLEIEKEAKLCMVSDGFSQYYDTLKIARDSKSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT7</accession>
    <name>A0A386PHT7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09445</name>
        <name evidence="3" type="ORF">EI377_04185</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679241.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00744"/>
    <dbReference type="EnsemblBacteria" id="AYE34631">
        <property type="protein sequence ID" value="AYE34631"/>
        <property type="gene ID" value="CP523_09445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60030">
        <property type="protein sequence ID" value="QAS60030"/>
        <property type="gene ID" value="EI377_04185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="125" mass="14190" checksum="7A7BFE6D0A7E91E2" modified="2018-12-05" version="1">MKEKVKVFKAVGDETRIKILVLLSKKNICAKGIARHLNISEAAVSQHIKILKDVNLITGYKKGYYVIYDLNKSVLEDAIDFMSLLINDDISSINNKLNINDFNILKCKNNCKSKKVCCKNLLEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU0</accession>
    <name>A0A386PHU0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hprK</name>
        <name evidence="13" type="ORF">CP523_13500</name>
        <name evidence="14" type="ORF">EI377_08400</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677582.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00796"/>
    <dbReference type="EnsemblBacteria" id="AYE35360">
        <property type="protein sequence ID" value="AYE35360"/>
        <property type="gene ID" value="CP523_13500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60751">
        <property type="protein sequence ID" value="QAS60751"/>
        <property type="gene ID" value="EI377_08400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="128"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="261"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="302" mass="34281" checksum="B9B751FC4BDBDD3B" modified="2018-12-05" version="1">MAVSVEKLINDFDLEVLVEGQPDTMISVSDINRPGLQLAGFYNYFASERIQVIGKAEWSFLDDMAVELRRKRVEKYFSFNIKCLIITRDLEPHKELLRAAKKNKIWLLRSNLVTTKFMSKLTIYLADKLAPETRLHGVLVDVYGIGILITGESGIGKSETALELIKRGHRLVTDDAVDIKEIDGELIGTSPRITIGMLEVRGIGIIDISALYGVSSVLQQKDIKLVMHFEHWKDDGDYDRLGLNNEHQDILGVKVRRLRIPVRPGRNIAVIIEAAAVNYRYYRMSDVTPVDIIESRMDKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU8</accession>
    <name>A0A386PHU8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Dihydropteroate synthase</fullName>
            <shortName evidence="8">DHPS</shortName>
            <ecNumber evidence="4 8">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folP</name>
        <name evidence="10" type="ORF">CP523_13550</name>
        <name evidence="11" type="ORF">EI377_08450</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="4 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35370">
        <property type="protein sequence ID" value="AYE35370"/>
        <property type="gene ID" value="CP523_13550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60761">
        <property type="protein sequence ID" value="QAS60761"/>
        <property type="gene ID" value="EI377_08450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13550"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="9">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="269" mass="29927" checksum="605D521CD16C4A44" modified="2018-12-05" version="1">MKIGNKEFNIKDRTFIMGILNVTPDSFSDGGQFNDVQSAVKRAKEMVAEGVDIIDIGGESTRPGAGYVSEEEEIKRVVPIIKAIKEELDVIISIDTYKSKTAEEAIKAGADIINDVWGFKRDRNIAKVAAKYKVQCILMHNREEKKYENLMDDMILDLEESINIALEAGVAKEDIILDPGIGFAKTYEENLIVMNNLEKIVSMGYPVLLATSRKSMIGLTLDLPANDRVEGTLSTTVIGIMKGCNFVRVHDIKENKRVAIMTDKILKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV9</accession>
    <name>A0A386PHV9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35673">
        <property type="protein sequence ID" value="AYE35673"/>
        <property type="gene ID" value="CP523_15225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="184" mass="21772" checksum="041F0F89E749B250" modified="2018-12-05" version="1">MNYEIFKTIVPPVIAGLITYRVANKNIFSNIRLQVANEQLKKVYLPLFIFLEPYLYKQPDIQIIKSFINMFNEIKSTNYELIDSDLLNCVQILEKSIHDNKYNFNYYESVCSILDKLFERTRKLLKLPTRSISYRLNNKQYGTSINEAIKFIEDIVLKVLPILLLTIIFIIIHTFINTFIHLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI24</accession>
    <name>A0A386PI24_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07235</name>
        <name evidence="2" type="ORF">EI377_01990</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673739.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34256">
        <property type="protein sequence ID" value="AYE34256"/>
        <property type="gene ID" value="CP523_07235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59663">
        <property type="protein sequence ID" value="QAS59663"/>
        <property type="gene ID" value="EI377_01990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="273" mass="32088" checksum="88116B6ED411EA54" modified="2018-12-05" version="1">MNMQKYNKNNPKLVNSVVCAIDILGFSQMIINSCTDGYGNDLLKEISYLINKNKQCIIPNKYSEGKIKIYTDNMIVGYPIKDDGEEELDEILDNVSEYQFNLSLEGLFVRGGVSIGEFYINEDIVFGPALLDAHNTESTLACYPRIILDNKTVNRLQKYINYYEVAPQQNKILIDSDGQWFLNYLNTIFKYYTECDNEYEFDMVKINLLMRHKLKIEEMLDLHKENITVWDKYVWTANYHNYFCDLNFPDERQLKISRKSLLSWPRQISNSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI64</accession>
    <name>A0A386PI64_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">recQ</name>
        <name evidence="13" type="ORF">CP523_14255</name>
        <name evidence="14" type="ORF">EI377_09160</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00271"/>
    <dbReference type="EnsemblBacteria" id="AYE35500">
        <property type="protein sequence ID" value="AYE35500"/>
        <property type="gene ID" value="CP523_14255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60886">
        <property type="protein sequence ID" value="QAS60886"/>
        <property type="gene ID" value="EI377_09160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
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    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="219"/>
            <end position="363"/>
        </location>
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    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="513"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="611"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="811" mass="93145" checksum="40CDAC6B48AFD2E5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI80</accession>
    <name>A0A386PI80_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10855</name>
        <name evidence="4" type="ORF">EI377_05650</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02505"/>
    <dbReference type="EnsemblBacteria" id="AYE34864">
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        <property type="gene ID" value="CP523_10855"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60259"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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            <end position="127"/>
        </location>
    </feature>
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            <begin position="152"/>
            <end position="216"/>
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            <end position="310"/>
        </location>
    </feature>
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            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="449" mass="48627" checksum="EC5EFBC5BEF6CA99" modified="2018-12-05" version="1">MKPETNETEKETKNLESTNFNSSSGVKQFTINQGQTTPLNLTIANKPIQGSLEITKIDAITKAPLQGATFNVLNLAGKVVGTGTTNSKGKLTINNLPAGNYTYVETVAPTGYVLDSTPVPFSIKTNGQVVTAKIVNQAIEGSLEITKIDAITEAPLSCAKFVIRNNQNNIVACGWTNSQGKLCFSLPYGSYTYQEVCAPKGYQSNTTPILFEINTSNEVVMANVTNQAITPPVNNNGILKITKVDLCNIGEVLPGAKFQIINSKGNIVKTVVTNNQGVAEVSLPAGIYYVIEIKAPIGYGICRTRRRITVMAGKTSELLSRNRKLNNFCKCNPCCYNSCDFPNYKIIPPVNNNGILKITKVDLCNIGEVLPGAQFQIVDCNGNIVKTVVTNNQGIAEVSLPAGIYYVIEIKAPIGYGICRTRRRITVMAGKTSELLSRDIKINGFSYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA5</accession>
    <name>A0A386PIA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14475</name>
        <name evidence="4" type="ORF">EI377_09450</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676835.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02488"/>
    <dbReference type="EnsemblBacteria" id="AYE35540">
        <property type="protein sequence ID" value="AYE35540"/>
        <property type="gene ID" value="CP523_14475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62196">
        <property type="protein sequence ID" value="QAS62196"/>
        <property type="gene ID" value="EI377_09450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="Primosome_PriB/ssb"/>
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    <dbReference type="Pfam" id="PF00436">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="25528" checksum="22FF06C99BF62AC2" modified="2018-12-05" version="1">MDNLMLNNKIYLEGKVISELEFSHEMYGEGFYTFAVEVTRLSDSVDILNITVSERLISNMDLSIDKEIIIEGQLRSYNKFVDGSNKLILTVFARNIEPCIEKSKNPNEIFLDGYICKEPVYRTTPFGREIADVLLAVNRAYNKSDYIPTIAWGRNSRFCQTLEVGDNIRVWGRLQSREYQKKISDTEVIRKIAYEVSISKMERVANEEQVDSEEIIGEEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB3</accession>
    <name>A0A386PIB3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoid occlusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">noc</name>
        <name evidence="8" type="ORF">CP523_07620</name>
        <name evidence="9" type="ORF">EI377_02310</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673888.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01133"/>
    <dbReference type="EnsemblBacteria" id="AYE35843">
        <property type="protein sequence ID" value="AYE35843"/>
        <property type="gene ID" value="CP523_07620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59715">
        <property type="protein sequence ID" value="QAS59715"/>
        <property type="gene ID" value="EI377_02310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023705">
        <property type="entry name" value="Nucleoid_occlusion_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04285">
        <property type="entry name" value="nucleoid_noc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="ParB" evidence="7">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="29828" checksum="3B74B4E49B97C6C9" modified="2018-12-05" version="1">MSKEIVNISVDKIFPNTYQPRKFFNEEALTELSQSIKEHGIIQPLTVRRRGDSFELVAGERRWRAARLALLELVPCNIIEITDTESAEIALLENLQREDLNFIEEAEAYYNLINDHKFTQDDLAKRMGKKQSTIANKLRLLKLSENVRTICIDNKLTERHARALLSLPNEEMQLKVVEKVVKNGLNVKKTEELINKELLKLAGEQLNDKNKKKVKSVFPAKLYVNTIKQVFDKFNIPADYKFKDSEECIEITVSIPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE7</accession>
    <name>A0A386PIE7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11155</name>
        <name evidence="2" type="ORF">EI377_05945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677060.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34924">
        <property type="protein sequence ID" value="AYE34924"/>
        <property type="gene ID" value="CP523_11155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60318">
        <property type="protein sequence ID" value="QAS60318"/>
        <property type="gene ID" value="EI377_05945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="64" mass="7381" checksum="2F29B2FCEAE2FB89" modified="2018-12-05" version="1">MVNIVTFCKNITDLGIREEQNGVAIEDNENGIFIIALDKIDTRKKYKISTPMEPEIEEVTPEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII5</accession>
    <name>A0A386PII5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="4">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroF</name>
        <name evidence="3" type="ORF">CP523_11375</name>
        <name evidence="4" type="ORF">EI377_06190</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673261.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02831"/>
    <dbReference type="EnsemblBacteria" id="AYE34964">
        <property type="protein sequence ID" value="AYE34964"/>
        <property type="gene ID" value="CP523_11375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60357">
        <property type="protein sequence ID" value="QAS60357"/>
        <property type="gene ID" value="EI377_06190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="91"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="337" mass="37100" checksum="17FEBCF189F3FA4D" modified="2018-12-05" version="1">MIIILKPKTKEEEINRLTEELENKGVKVNQVIGTELIILGLVGDTSKIDPLQIEANYNVEKVMHVQEPFKKSNRVFHPENTVVDINGEKIGGKKIAMIAGPCSVESEEQITFIADKVKKLGANFLRGGAFKPRTSPYSFQGLKYDGLELLKIARSKTGLPIVTEIMSPYDIEVFEENVDVIQVGARNMQNFDLLNELGKINKPILLKRGLSATIEELLMSAEYIMAGGNESVILCERGIRTFETYTRNTLDLSAIPAIKKMSHLPVVVDPSHATGKRFMIDPLAKAAVAVGADGLIIEVHNNPKKALCDGPQSIKPNQYGSLINDLKVIAKAVGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII7</accession>
    <name>A0A386PII7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">greA</name>
        <name evidence="9" type="ORF">CP523_12510</name>
        <name evidence="10" type="ORF">EI377_07395</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675304.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02011"/>
    <dbReference type="EnsemblBacteria" id="AYE35177">
        <property type="protein sequence ID" value="AYE35177"/>
        <property type="gene ID" value="CP523_12510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60580">
        <property type="protein sequence ID" value="QAS60580"/>
        <property type="gene ID" value="EI377_07395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="7">
        <location>
            <begin position="82"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="154" mass="17356" checksum="5E244A6BFFFC5A75" modified="2018-12-05" version="1">MNNQLTEENIRKLREELDYRLTVKRAEIAKEKAIAAAHGDRSENAEYKEACANYRENDNRIQYLLTMISTATIIDDKDIDKSVLGINSKAKIKFIDDDFETEVTLVTTMDLDPDNMRISIESDLGKALSGKKAGDIVEVNAPGENYSVEILEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ2</accession>
    <name>A0A386PIJ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14980</name>
        <name evidence="3" type="ORF">EI377_09935</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676050.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35630">
        <property type="protein sequence ID" value="AYE35630"/>
        <property type="gene ID" value="CP523_14980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61017">
        <property type="protein sequence ID" value="QAS61017"/>
        <property type="gene ID" value="EI377_09935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="158" mass="18652" checksum="A6C1C9C119BBA725" modified="2018-12-05" version="1">MHIIEKIKAKKKGFVIIESLGVLLIVLFFSLILNKIIINNIKKSNVYYIAEDIKTLTLNEEKLLMEAIIFVNKEDEVKIKIKEKILNENNNIQGEDFKFIIKYSQNKNLSLVLTRDKTYIEEVKSSNKRRIGIETKLKESNEIEFIMLTPKYYETKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK6</accession>
    <name>A0A386PIK6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_Mga domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675205.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35207">
        <property type="protein sequence ID" value="AYE35207"/>
        <property type="gene ID" value="CP523_12675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013199">
        <property type="entry name" value="HTH_Mga_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08280">
        <property type="entry name" value="HTH_Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Mga" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="95" mass="11284" checksum="B8B2A8ECB34F8F4F" modified="2018-12-05" version="1">MFKENLLESSEKIEIEILKTLYINNGNFSKYNFCNELHISFPTLKLYIKNINMMFSNHCNGQASIHIIKETILLKYKTDISLDNFISIYRKFIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS8</accession>
    <name>A0A386PIS8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_12025</name>
        <name evidence="8" type="ORF">EI377_06845</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673479.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02962"/>
    <dbReference type="EnsemblBacteria" id="AYE35084">
        <property type="protein sequence ID" value="AYE35084"/>
        <property type="gene ID" value="CP523_12025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60477">
        <property type="protein sequence ID" value="QAS60477"/>
        <property type="gene ID" value="EI377_06845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="35245" checksum="F9D8B9518E6B4CEB" modified="2018-12-05" version="1">MRYILAFILAFIIVYLIMPILMKLSLKYNFTDKPTKRKNHRGEIPLCGGIGMFIGFFIVYLIINNNTSVTEKMWVFISASLILIIGLADDYYKAHGKEFPIYPRLIIQLLAAALIFKAGIAFRGFANPFTGEYITLNPIIQFLLTITWIFGVTTVINWSDGMDGLAGGLSFISAITFAGVALILGQSESIIMSLIVSGIVVGFLMYNKYPAKIFMGDSGANFLGFLLSIIALDGAFKQATVMSLFIPILALAVPIFDNIFVILKRFSEGKPVYQADRSQIHYRLEAKGFSIKQVVTYINIISLAFSIISIILLLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW5</accession>
    <name>A0A386PIW5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="7">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP cyclohydrolase I</fullName>
            <shortName evidence="7">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">folE</name>
        <name evidence="9" type="ORF">CP523_13535</name>
        <name evidence="10" type="ORF">EI377_08435</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677593.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00803"/>
    <dbReference type="EnsemblBacteria" id="AYE35367">
        <property type="protein sequence ID" value="AYE35367"/>
        <property type="gene ID" value="CP523_13535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60758">
        <property type="protein sequence ID" value="QAS60758"/>
        <property type="gene ID" value="EI377_08435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13535"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="8">
        <location>
            <begin position="8"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="184" mass="20892" checksum="8D603FE766A2C926" modified="2018-12-05" version="1">MIDKEKIKTGVKLILEAIGEDVNREGLIETPDRIARMYEEIFSGIGQTAEDALSKTFKVENNDLVIEKDITFFSMCEHHLVPFYGKAHIAYIPNERVAGLSKLARCVEVYAKKPQLQEKLTSEVADALMEYLGAEGVMVVIEAEHMCMTMRGVRKPGTKTVTTTYRGRFKEDYELRKEVLSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW8</accession>
    <name>A0A386PIW8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10720</name>
        <name evidence="4" type="ORF">EI377_05505</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674121.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01358"/>
    <dbReference type="EnsemblBacteria" id="AYE34838">
        <property type="protein sequence ID" value="AYE34838"/>
        <property type="gene ID" value="CP523_10720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60232">
        <property type="protein sequence ID" value="QAS60232"/>
        <property type="gene ID" value="EI377_05505"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="112"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="271" mass="29949" checksum="1217B9B39732D477" modified="2018-12-05" version="1">MKYISIIESCYPSLSKSEKKVADYILAEKGNIIYETLLEISKKINVGEATILRFVKKIGFNGFQDLKLQIAKDDKPENKSYHENYMDSIANNMTSTILNTKKVLDIQQLNLSIKLIEESDRLFFYGVGASGLAAYEAQSRFVRMGKIGTSITDSHFQLMYSSLCNGNDVIIALSLSGYTKDMIDSLTVAKKQNAKIIAITNYALSPIAQIADCLLLTAGKENLLDGGSLISKISQLYVIDLLCTGYALLNKDDVLDIKEKTAELLIGKLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ85</accession>
    <name>A0A386PJ85_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CotS family spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10030</name>
        <name evidence="2" type="ORF">EI377_04830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676563.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00335"/>
    <dbReference type="EnsemblBacteria" id="AYE34712">
        <property type="protein sequence ID" value="AYE34712"/>
        <property type="gene ID" value="CP523_10030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60113">
        <property type="protein sequence ID" value="QAS60113"/>
        <property type="gene ID" value="EI377_04830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="333" mass="39858" checksum="B627C6A883795A19" modified="2018-12-05" version="1">MMREFEIERQFDIKIEVIKANKGVYYLKTNKGEKCLKKINYGPQKLLFVYGAKEHLINNGFNNVDRYFLNIDGEPYALVNEDLYTLSEWLEGRECDFHNIDEVKLAAKTLANMHKASKGYDPPENSKLKSDLGRWPHLMTKRIKSLDKMRDMVRKKNGKNDFDLLYLKSMEFYKDMGKKALRTLEESSYMKLCEIAEEEKSFCHHDFTYHNIILDKENQAHVIDFDYCKREIRAFDVSNFMIKVLKRVDWNIEFAKAIIDSYNDVYPLSKDEYKVLYAFLQFPQRYWRLANRYYYNEVNWGQNTFSNKIEAIINEQEKLLKFLEEFKSLYSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJA1</accession>
    <name>A0A386PJA1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4004 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF4004 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11500</name>
        <name evidence="2" type="ORF">EI377_06315</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673314.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02858"/>
    <dbReference type="EnsemblBacteria" id="AYE34988">
        <property type="protein sequence ID" value="AYE34988"/>
        <property type="gene ID" value="CP523_11500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60381">
        <property type="protein sequence ID" value="QAS60381"/>
        <property type="gene ID" value="EI377_06315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025063">
        <property type="entry name" value="DUF4004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13171">
        <property type="entry name" value="DUF4004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="206" mass="24495" checksum="A4A8A502FB9CAA52" modified="2018-12-05" version="1">MFKELISKKELLEVMGISYGQLYRWKRKGLIPEEWFIKKSVSTGQETFFPKEKVLERIRIILELKSDASLDELAHRFSNNIKDIKINRDYIINSNIVPEQIVKMFEEIIEVDTLYDESNLFALFIYQELLKIGLLNLEEVKNITLSTVRDYKKIQDKDYTLIIKRKLGICFYYAINGDEELFEDNEAILIYKIIIKRIIEKVNNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB4</accession>
    <name>A0A386PJB4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">CP523_10180</name>
        <name evidence="15" type="ORF">EI377_04995</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676641.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00365"/>
    <dbReference type="EnsemblBacteria" id="AYE34742">
        <property type="protein sequence ID" value="AYE34742"/>
        <property type="gene ID" value="CP523_10180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60144">
        <property type="protein sequence ID" value="QAS60144"/>
        <property type="gene ID" value="EI377_04995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="371"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="504" mass="55524" checksum="DA9049870B2577BB" modified="2018-12-05" version="1">MNIKPEEITSIIKKEIERYEKEITTVDSGTIIQIGDGVARVYGLDDCMEGELLEFPNNVYGMALNLEQDNVGCVLLGPEEGIKEGDIVKRTNKIVEVPVGEALLGRVVNSLGEAIDGKGPINHAEYRAIEVPAPSIIDRSSVNEPLQTGIKAIDSMIPIGKGQRELIIGDRQTGKTAIAVDTILNQKGKDVICIYVAIGQKQSTVANIVNTLEEMGALDYSIIVSGTASESAPLQYLAPYAGCSMGEYFMHQGKDVLIIYDDLSKHAVAYRTMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLSKENGGGSLTALPIIETLAGDVTAYIPTNVISITDGQIFLESDLFHSGQRPAVNAGISVSRVGGNAQIKAMKQVSGTLRLELAQYRELAAFSQFGSDLDKDSKKRLEKGKRLVEVLKQDQYSPMPVEKQIVILYATVNDFLSDIKVEHVRKFEKELLEYADTHYRDLLKEIVDGKVLSDKVKFELDKCIIEFKKLFLQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE3</accession>
    <name>A0A386PJE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34772">
        <property type="protein sequence ID" value="AYE34772"/>
        <property type="gene ID" value="CP523_10360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="91" mass="10507" checksum="709E79A915A8DC25" modified="2018-12-05" version="1">MEKIYFGSSFIALIGLMIILVLLMLGKPIPDLIFNIFCGINIICILSSISINRKNRINNKSEKNLKFKKIYIYAYILLFIPIIVMQLLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG2</accession>
    <name>A0A386PJG2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_10475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01405"/>
    <dbReference type="EnsemblBacteria" id="AYE34792">
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    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10475"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:alpha,alpha-trehalase activity"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
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    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="796"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="741"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="827" mass="92661" checksum="CC8DE2300ADC7075" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI5</accession>
    <name>A0A386PJI5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_13505</name>
        <name evidence="12" type="ORF">EI377_08405</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677584.1">
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00797"/>
    <dbReference type="EnsemblBacteria" id="AYE35361">
        <property type="protein sequence ID" value="AYE35361"/>
        <property type="gene ID" value="CP523_13505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60752">
        <property type="protein sequence ID" value="QAS60752"/>
        <property type="gene ID" value="EI377_08405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
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        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="51574" checksum="0F91B46FB042D6B9" modified="2018-12-05" version="1">MSEKLKSKSAWLKYNNKDKEEIFHFCNGYIDYMSVCKTERECVLTAIDMVQAMGYRDLEEIIENGEDLKAGDKVFINNKDKMLALFLIGKEPIEKGMRILGAHVDSPRLDLKQNPLYEDGELAMMDTHYYGGVKKYQWVTLPLAIHGVVVKKDGTKIDVVIGEDDKDPVIGVSDLLIHLAGDQLQKKGSNVIEGEDLNILVGNMPLEGEKKDAVKANILKLLKEKYDFEEEDFLSAELEVVPAGKAREFGLDRSMVMAYGQDDRICAYTSLMALLEVDDVDYTSVVLLVDKEEVGSNGATGMHSKFFENVVAEVMDRTGDYSELKLRRALANSKMLSADVTAAYDPNYPSVLEKKNSSYFGRGLVFSKYTGARGKSGCNDANAEFMAWLRNVMDSNNVSFQTAELGKVDQGGGGTIAYILAEYNMEVIDCGVALQNMHAPWEVSSKVDIFETKNGYKAFLEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU9</accession>
    <name>A0A386PJU9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11015</name>
        <name evidence="3" type="ORF">EI377_05810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677114.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34896">
        <property type="protein sequence ID" value="AYE34896"/>
        <property type="gene ID" value="CP523_11015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60291">
        <property type="protein sequence ID" value="QAS60291"/>
        <property type="gene ID" value="EI377_05810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="415" mass="49061" checksum="4D29E4D066372E32" modified="2018-12-05" version="1">MHFIPIINILIILVLCYILFIKILDNKNLFKISIGFSLFYFILTLIIYFNNLSHGFDSGILYGNIANAHFCDEFRYFEDSKILYGHFINDGFKPWFNRSLPPWEFIDIDGHPGFGNYNIFVVFLSLLRLIGFKTVLDFITLKLIFYPISIFFLYKLFKIYLDEKYSLISLIIFSILPGYILNNTLLMRDNIILFLVIVCFYIIFSHNLNLKYKTIALIPLLLCLLIFRAYLAPIFIATIIFCYKNSKKIFSFRDGLFFIVIIFTLVFFTTFKFNNGELMIFGGFSDEQIRILQEEFTIRYGSGLMTPLKVFYLTLLHIFYVPPFLNFWSTNIIYLILFSMGNIFSVVTSLFFIPSYFYLAIKNRNENIIYLLKFTFYFTFLCGLILVSKDGFIITRLSLMWTPLFFIIITKIFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJY3</accession>
    <name>A0A386PJY3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS glucose transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_11215</name>
        <name evidence="16" type="ORF">EI377_06005</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677040.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00897"/>
    <dbReference type="EnsemblBacteria" id="AYE34936">
        <property type="protein sequence ID" value="AYE34936"/>
        <property type="gene ID" value="CP523_11215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60330">
        <property type="protein sequence ID" value="QAS60330"/>
        <property type="gene ID" value="EI377_06005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="418"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS60330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="496" mass="52881" checksum="34C01023C825780A" modified="2018-12-05" version="1">MFKSLQKIGKSFMLPIAILPAAGLLLGIGGALSNPNTVNAYPFLNISWLQGIFKIMSSAGDVVFGNLALIMCIGLAVGLAKKDKGTAALAAAVAFLVMNASIKGMISAFNPDVASIDTGVVGSIIIGSVVAYLHNKYHNIQLPAVLGFFGGSRFVPIVSSFTSIFIGAIFFLIWPTFQGWLTNAGTAIAGLGPVGTFLYGFLLRLTGAVGLHHMIYPLFWMTELGGVATVAGQTVVGAQNIFFAELADPNHVGLFTEGTRFFAGRFATMMFGLPAACLAMYHCVPKAKRKLVGGLFLGAAITSFVTGITEPIEFMFLFVAPWLYVVHAVFDGLSFFIADILNISIGNTFSGGIIDFTLFGVLQGNAKTNWVLVLAVGAVWAVLYYVTFRFLITKFNVMTPGREEDSEEVKVVTKETIKETAVKVLEALGGEENIEDVDACITRLRVSVKDVSKVDKETIKALGATAVLEVKGGVQAIFGAMADPIKQRINEIIGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK39</accession>
    <name>A0A386PK39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stage V sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_14880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676088.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01307"/>
    <dbReference type="EnsemblBacteria" id="AYE35611">
        <property type="protein sequence ID" value="AYE35611"/>
        <property type="gene ID" value="CP523_14880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013438">
        <property type="entry name" value="SpoVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02615">
        <property type="entry name" value="spoVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="376" mass="41248" checksum="9F9F558219929FF9" modified="2018-12-05" version="1">MKKTRFKRKMGEIDYGIFYAILILLAIGVVMVYSASSYYAMFKEGDSMFYLKRQIVWATLGLLSMVFMMTIDYHKLRGYTKFLMIITVPLLLAVHLFPAVNGAKRWIQLGPASFQPSELAKYVVVIFLAKSIDMKGDGIKKFSTGIIPYLAVSGGFAALVLAQKNLSIASIIMIVTFIMLFVGGGRIKDLFGKLAPALLAAVGAFIVLEPYRMARLMNFTNPWQDAAGDGYQLIQSFYALGAGGITGLGLGQSRQKTLYMPEPHNDFIFSIIGEELGLIGCLCIMGLFLFFIWRGISVSMKARDTYGTLLAVGITSIIAVQAIINIAVVTGSMPVTGVPMPFISYGGTSLVINMMAMGILLNISRQTQGKEEKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE3</accession>
    <name>A0A386PKE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12595</name>
        <name evidence="3" type="ORF">EI377_07500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675244.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01993"/>
    <dbReference type="EnsemblBacteria" id="AYE35192">
        <property type="protein sequence ID" value="AYE35192"/>
        <property type="gene ID" value="CP523_12595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60596">
        <property type="protein sequence ID" value="QAS60596"/>
        <property type="gene ID" value="EI377_07500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="632" mass="72520" checksum="52F398C251AC79CC" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE6</accession>
    <name>A0A386PKE6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675215.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35202">
        <property type="protein sequence ID" value="AYE35202"/>
        <property type="gene ID" value="CP523_12650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="204" mass="22273" checksum="C4746CE04FE4DBC5" modified="2018-12-05" version="1">MNKEKIRGFIKTKIGACVLTGLITFVVTGVLFNEEAQLQELSSKVEKSIVELEKKDTEIKDLSDKVASAKPYFDMKAEEQAQLAEKVRKEEEDRVTREAADKEAKNKAELEAKSVTLENGNFVSGTDFEPGVYDIIAISGGGNVVSSNMFDGGINAIMGDDNKIAEMNGLGMGDMYKKEYKNIKLPNSVTLSLDGVGVKLVPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKL0</accession>
    <name>A0A386PKL0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679086.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35831">
        <property type="protein sequence ID" value="AYE35831"/>
        <property type="gene ID" value="CP523_05730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="61" mass="7304" checksum="472B53AC9EAACDE0" modified="2018-12-05" version="1">MFDLFNVPALDDAVKSGKEIRYSHHPEQYGDCALLKEWEYLKSEYGFKRLIKEGEFWYAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKL5</accession>
    <name>A0A386PKL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage portal protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13185</name>
        <name evidence="2" type="ORF">EI377_08030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02572"/>
    <dbReference type="EnsemblBacteria" id="AYE35302">
        <property type="protein sequence ID" value="AYE35302"/>
        <property type="gene ID" value="CP523_13185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60691">
        <property type="protein sequence ID" value="QAS60691"/>
        <property type="gene ID" value="EI377_08030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="443" mass="52024" checksum="D753886FAF427945" modified="2018-12-05" version="1">MNLNKLINKLFKKEFGLDLHNYEHLELVKKAYGSYHVFRNIYEKMYRYYKGDTDAIRKYLFVTDRSNLKVNVNYIKKFIKEEVAYTLGNDITYESRTDDTNIVKDIEYYTAHWDELHDTDLMKYLLIFTEVYELYYIDKKADFCSKIIKPSDGYAYKDSSSGKVLFFIHTFKNDFEQHNNIDVYTENYIYHFNDKFEEIASPSKNLFKEVPVSIGILSYEKESDSLYKDIKGLQDAFETNLSDVGNEISDFRNAYLKFIGCKIDNDDVPKMKRLGVLQLPGKGASADWLIKNINDTFIQNTLDRYHDTMYEIACHINHNEKLQSNLSGITLRSRLIVLENKCNLQIKAHRNIVKNRLRFLFIYLDLKKNKIYDYKDIKALYTPNIPSDDLATAQMLSQVPDGIISKDTARGRFSFINNKVVEAEKVKKEQEEEFAIDLNNLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKQ0</accession>
    <name>A0A386PKQ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DMT family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">EamA/RhaT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10780</name>
        <name evidence="5" type="ORF">EI377_05565</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674092.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34849">
        <property type="protein sequence ID" value="AYE34849"/>
        <property type="gene ID" value="CP523_10780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60243">
        <property type="protein sequence ID" value="QAS60243"/>
        <property type="gene ID" value="EI377_05565"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="70"/>
            <end position="92"/>
        </location>
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        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
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        <location>
            <begin position="184"/>
            <end position="202"/>
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        <location>
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            <end position="236"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="267"/>
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        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="4"/>
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        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="154"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="33398" checksum="B8CD768FCCDCF56A" modified="2018-12-05" version="1">MKTKGIILTMLSSITFGFAFTLGPLTYGAEGSNPVTLTFLRNFLSLPFLLIIVLFLKIDLKVTKKQFRDLVILGFVGNAITTLLLNIAFAYIDVGIVTPIHFTYPIFVTLGCVMFFQEKLSKQKILALIIAMSGISCFFVSALTSSSFGSSALLGLILAVVSGIFYAFYIIFMDKSGLKGEQPFKITFYVALASTIGMFLYGEFTQQLVFSTLTTKAWIISVIFAFLCTVVALSLLQLGIKYVGASEAAVITTFEPITSVIFGAILLGEKITLIKIIACILIFAGVLTLSFTKNKEASIDTKEANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKW5</accession>
    <name>A0A386PKW5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14010</name>
        <name evidence="4" type="ORF">EI377_08915</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00219"/>
    <dbReference type="EnsemblBacteria" id="AYE35452">
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        <property type="gene ID" value="CP523_14010"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60840"/>
        <property type="gene ID" value="EI377_08915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14010"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NT_sf"/>
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        <property type="entry name" value="Polbeta"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="300" mass="35208" checksum="95A180F82C47D311" modified="2018-12-05" version="1">MAKAIIDYQKAFKEITNVLTKNENILSIFVFGSMVSGDLWEESDIDLFVLCKDEFDKVRDVYLESLSIPIHIKFLSKESFINIYNESSQKRVLKDTLLSSKLIYSKDKDIDVIYTDIKYLTFKDKEIWNLVYLGKLLKDIGICKKYLHTGGLYTCYEILIRVFDSYSKLYLNMNGLVVSKDSLTMACNLNDSFNEKVKDVLFKEFDINHINEALKYIETYVDLNLKVAAKVLIEFLENENRALSSYEIKNSTIFKNFDIKIENILKKLYKNNMVSKDVRDFKDPFENLLTEENVYSYKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL19</accession>
    <name>A0A386PL19_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11710</name>
        <name evidence="4" type="ORF">EI377_06530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673391.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02901"/>
    <dbReference type="EnsemblBacteria" id="AYE35029">
        <property type="protein sequence ID" value="AYE35029"/>
        <property type="gene ID" value="CP523_11710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60423">
        <property type="protein sequence ID" value="QAS60423"/>
        <property type="gene ID" value="EI377_06530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="348" mass="39078" checksum="7C4269450FEE118D" modified="2018-12-05" version="1">MKKINFGIVGVGRLGKAHAENLAFKIPNANLLAVCSIDKSQIDEVQKAWNIPYRYASFDEMLTNKELDAIFIASPSGFHCNQIKKALDAGFHVFSEKPLGLYLEDTIEAMKAVNSNSEKIFMLGFMRRYDKSYAYAKKKIKEGFIGKPVLVRCYGLDPAKALPSFLKFAKDSYSGGLFLDMAIHDIDLARWYLESEADELWAIGDAYEYEEFKEINDAETGSAMIKFKNGTMALLVAGRNCAHGYHIETEIIGTKGTLRIGTTPNKNLVTIFDERGVNKECAGGFLERFEDAYLEEVKEFVNCILENRKPNVTVEDGVLSTIVGYACKESFETGKLVKIDYSKYEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL27</accession>
    <name>A0A386PL27_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11790</name>
        <name evidence="9" type="ORF">EI377_06610</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02916"/>
    <dbReference type="EnsemblBacteria" id="AYE35039">
        <property type="protein sequence ID" value="AYE35039"/>
        <property type="gene ID" value="CP523_11790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60432">
        <property type="protein sequence ID" value="QAS60432"/>
        <property type="gene ID" value="EI377_06610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="67" mass="7470" checksum="920604C6C87C5C10" modified="2018-12-05" version="1">MIMSKKLYKIKSLKKISGVCAGFSEFIDADVTLVRVLALLIILFSFPIGLIFYIGCTIIMPDKSEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL59</accession>
    <name>A0A386PL59_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-galactose-binding periplasmic protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-galactose/ D-glucose-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_14715</name>
        <name evidence="11" type="ORF">EI377_09675</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676146.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01342"/>
    <dbReference type="EnsemblBacteria" id="AYE35582">
        <property type="protein sequence ID" value="AYE35582"/>
        <property type="gene ID" value="CP523_14715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60967">
        <property type="protein sequence ID" value="QAS60967"/>
        <property type="gene ID" value="EI377_09675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01539">
        <property type="entry name" value="PBP1_GGBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044085">
        <property type="entry name" value="MglB-like_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362737" description="D-galactose-binding periplasmic protein" evidence="8">
        <location>
            <begin position="29"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="9">
        <location>
            <begin position="42"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="348" mass="37543" checksum="E82C168F09D13697" modified="2018-12-05" version="1">MKKIKKLLVMVMATVMVATSLTACGSKKDGGGETASGDKVKVGVCLYKFDDTYISTVRQSLEEIQKENKDKVEFTFYDGKGDQATQNDSIDTLLQKDVDLLLVNLVDTGAAQTVVDKIKKSDVPVVLFNREPSTTDAIKSYEKSVFVGTNAKEAGELQGKILADLWEKDSKAIDKNGDGVMQYVMLQGEPDNPEAVARTKFSVSTINDKGIKTDELAQQVCNWDQALAQNAMEAWFAKHGDKIEVVIANNDGMAQGAIAALQAQGYNNGDPAKTIPVVGVDATAAAQDLIAKGQMTGSVLQDAPAMAKALYESGMNLVGGKKANEGTEYKFDDTGVSIRIPYQEYIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLJ6</accession>
    <name>A0A386PLJ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APC family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_15745</name>
        <name evidence="7" type="ORF">EI377_10460</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678910.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00109"/>
    <dbReference type="EnsemblBacteria" id="AYE35772">
        <property type="protein sequence ID" value="AYE35772"/>
        <property type="gene ID" value="CP523_15745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61110">
        <property type="protein sequence ID" value="QAS61110"/>
        <property type="gene ID" value="EI377_10460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="444" mass="48118" checksum="968DDE01D3501825" modified="2018-12-05" version="1">MKKNEYGLFTAIGMIVGVVIGSGIFFKSDNILIATNGSVSLGILVFCIAAIGIIFGSLTISELASRNTKAGGIITYAEYSYNKSVACAFGWFHTFLYYPTLISVVTWVSGIYISMLFGLESTLETQILIGLAMMLIIFITNILSAKLGGIFQNASTVIKIIPLIFIAIAGLVFGKPSAIAITDITNMQSFAWISAIAPIAFSFDGWIVATSIAHEIKEPSKNLPKALVVAPLFILGIYLLYFVGISIYVGPETVMSLGDAHVDLAANNIFGAWGAKIILTFVVISILGTVNGLTMGLTRLPYSLAIRGMFPKYKTFSKVNEKLGMPIQSSIIALVISITWLVIHYLTQKFSLLPNSDISEISITINYVLYILLYAKVFRMGLSGEIVGVWKGLLNPLLATLGSLIILVGSIGNPLFWINASISVIILLSAIVFWKYQSKKVNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM73</accession>
    <name>A0A386PM73_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_15620</name>
        <name evidence="7" type="ORF">EI377_10335</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678625.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00567"/>
    <dbReference type="EnsemblBacteria" id="AYE35749">
        <property type="protein sequence ID" value="AYE35749"/>
        <property type="gene ID" value="CP523_15620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61086">
        <property type="protein sequence ID" value="QAS61086"/>
        <property type="gene ID" value="EI377_10335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="15417" checksum="46FCEFFAECEDBE37" modified="2018-12-05" version="1">MKRIKIDRKKCVGCLTCTTACLVSHESEETRSRITIDGNGKYAPIFCRHCDKPECVYTCMTGAMSKDKETGLVNYDKNKCASCYMCIMACPYGVLKAEKEKHKEIMKCDMCKNSKEGTPQCVEKCPMSAITLEEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAS1</accession>
    <name>A0A386PAS1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_00495</name>
        <name evidence="10" type="ORF">EI377_10985</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 H(+) + 2 superoxide = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676314.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PAS1"/>
    <dbReference type="STRING" id="1504.GCA_900092375_00628"/>
    <dbReference type="EnsemblBacteria" id="AYE33033">
        <property type="protein sequence ID" value="AYE33033"/>
        <property type="gene ID" value="CP523_00495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61202">
        <property type="protein sequence ID" value="QAS61202"/>
        <property type="gene ID" value="EI377_10985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sod_Fe_C" evidence="8">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="204" mass="23436" checksum="A2ECF8BE7CD6DA8C" modified="2018-12-05" version="1">MKYDKIILPYSYDALEPYIDALTVQIHYEKHLQSYVDNLNSLVAIDPKFFDEKPLNEILSNTNSIPVEIRQGVINQGGGVDNHNFYFSILSPNAKTMPEGRLLTAINNTFGSFDNMKEKLNKLSIGKFGSGWGWLVVNEYCGLEIITTSNQNSPLSVNKKPLIAIDVWEHAYYLKYKNLRKDYVNNIWNLIDFNIIENLYNSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBD3</accession>
    <name>A0A386PBD3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Formate acetyltransferase</fullName>
            <ecNumber evidence="5 14">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pflB</name>
        <name evidence="17" type="ORF">CP523_01540</name>
        <name evidence="18" type="ORF">EI377_12060</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5 14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675656.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00860"/>
    <dbReference type="EnsemblBacteria" id="AYE33235">
        <property type="protein sequence ID" value="AYE33235"/>
        <property type="gene ID" value="CP523_01540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61407">
        <property type="protein sequence ID" value="QAS61407"/>
        <property type="gene ID" value="EI377_12060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01540"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0556">Organic radical</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="16">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="15">
        <location>
            <begin position="620"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="13">
        <location>
            <position position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE33235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS61407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="743" mass="83533" checksum="92A48C369E3800C4" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBW8</accession>
    <name>A0A386PBW8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgB</name>
        <name evidence="7" type="ORF">CP523_02630</name>
        <name evidence="8" type="ORF">EI377_13165</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673896.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00441"/>
    <dbReference type="EnsemblBacteria" id="AYE33435">
        <property type="protein sequence ID" value="AYE33435"/>
        <property type="gene ID" value="CP523_02630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61609">
        <property type="protein sequence ID" value="QAS61609"/>
        <property type="gene ID" value="EI377_13165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="131" mass="14541" checksum="1D2F573493829C77" modified="2018-12-05" version="1">MNFTNDSTFSFIKRGLDVATLKGKVISNNLANINTKGYKKFSVDFKENLEKQSEGFNLKKTNVKHIGGELQNGDISVKRDKSTSMRMDGNNVDLDLEKVNQAANTLMYNALITQANSKMNMTKTVISGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC20</accession>
    <name>A0A386PC20_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_01955</name>
        <name evidence="5" type="ORF">EI377_12475</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678263.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01157"/>
    <dbReference type="EnsemblBacteria" id="AYE33310">
        <property type="protein sequence ID" value="AYE33310"/>
        <property type="gene ID" value="CP523_01955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61480">
        <property type="protein sequence ID" value="QAS61480"/>
        <property type="gene ID" value="EI377_12475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="77"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="241" mass="27755" checksum="FAE15E585FA98FC3" modified="2018-12-05" version="1">MEEKIVRFYKGIHYILYMIVLRLKAIKLWFIRKTKGVDAGYEYSAKVGRDWANYTINKAIEMNVTIKGKENIPERACCFIGNHTSILDIPLLMDSAGRAMGFIAKKEMLKTPVIGYWMQQYHCVPLDRENARSAIKVIQQGAENIKNGYSMCIFPEGTRSKDGKLQEFKKGSLKLATKAKAPIVPVAIDRAYRAFEIDRKFKSIDITITFCEPIYTENLTRDEEKELAMRVRNIIEKALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCC8</accession>
    <name>A0A386PCC8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sbcD</name>
        <name evidence="12" type="ORF">CP523_03585</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677734.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02228"/>
    <dbReference type="EnsemblBacteria" id="AYE33613">
        <property type="protein sequence ID" value="AYE33613"/>
        <property type="gene ID" value="CP523_03585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="10">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="11">
        <location>
            <begin position="291"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="405" mass="46693" checksum="5CFAA23FB240BAB1" modified="2018-12-05" version="1">MRILHTGDWHLGKNLEGYSRMDEQEEFLNDFIDIVEENNIDLVIIAGDVYDSSNPPARAEKMFYDTLKKISKNGERLTLVIAGNHDNPERLVAAGPLAMEHGIIMLGTPKSTVEEGEYGKHKVIKSGEGFIEIEINNERSIILTVPYPSEKRLNEVLYGEMDSDEEKMKSYGERIHSLFNSLKENYREDTINLVVSHLFVMKSEESGSERSIQLGGSYIVDGSCFPKEAQYVALGHVHKPQIVPGTEKKARYSGSPLHYNKKEINFTKKCFIVDVKVGEESKINEVEFKVYKPIEIWKCTSIEDAINKCEENRDRSCWVYLEINTDRYIREDEIKQIKDIKKDILEIIPKLNDFEENEEEVSIYEKSFEDIFKDFYKKERGVEADHEILELLLSIVEGGEENETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD17</accession>
    <name>A0A386PD17_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33883">
        <property type="protein sequence ID" value="AYE33883"/>
        <property type="gene ID" value="CP523_05035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="375" mass="42958" checksum="FD5ABF148A2B9D94" modified="2018-12-05" version="1">MKLIAQKKSVFFYLLFFIILSIAKGMGMDSGDMAFILIGLFSGVFLLTHVLSQGYTRRELVIIFIFVTLGIVTLIFSKKITVLITIIAIVFAKNIPLNRLIEVVFKFKILTFIVTIILSLLGIIENNKSFRFMENGDVITRYSLGFPHANVTYLNFFIIVLLYLYIYYDKVKLRNYVVILFLSMLLYKITDSRTGIISVIISLIIPIVLKNKKIIKNAITRKIIIFLPVICGGFSVFSGIYYSSGNLVLQKINQALTGRIELASKFLSLYKIKPFGQVIIEGSNLNGSYLRIDNGYISLLLAYGIVSFIVFIILETKLLKKYMLDERYREILLIVSFLIYGITEVYIYNIFVNISLIFLCELLYKPVSDERYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD79</accession>
    <name>A0A386PD79_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05420</name>
        <name evidence="4" type="ORF">EI377_15980</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677968.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02584"/>
    <dbReference type="EnsemblBacteria" id="AYE33953">
        <property type="protein sequence ID" value="AYE33953"/>
        <property type="gene ID" value="CP523_05420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62104">
        <property type="protein sequence ID" value="QAS62104"/>
        <property type="gene ID" value="EI377_15980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022627">
        <property type="entry name" value="DUF3502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12010">
        <property type="entry name" value="DUF3502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362913" evidence="1">
        <location>
            <begin position="30"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="349"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="481" mass="54722" checksum="B8CE8F85FE58B767" modified="2018-12-05" version="1">MKIKKLLALAACATLTTTTLLTGCGNSGSESGKKGNEPVTLTWYTIGQEPKDLQMVEDEVNKYLEEKINAKVDMKFIDYGDYNQKMSVIVNSGENFDLAFTCSWAGDYLGNSRKGAFLELNDYLETIGKDMKEAIDERFWDGATIDGKIYAVPNQKEISTAPMWAFTKEYVDKYNIPYQDIHTIQDLEPWLKIIKENEPGVTPLYITKGFSAPQYFDQLVDPVGVEHGDDSLKIKNMFETDKMKEQLECLRKYYEAGYINADASTAVDDKSVKRFVTKGDGQPYAEKLWSKDLKYEVVSSQIMDTYITNASTTGSMIAVSKNSKNPEKAVEFLNLLNTDEYLRNLINYGIEGTHYEKVGEKQIKLLPKEEDYRVGYYTMGNLFLTYILDNEPLTKWDEFQDFNNKAKNSPALGFKFDPSSVSTEIAAVNNVLEEFKATIYSGSVDINEYLTKLNNKLKEQGIDKIIEEMQKQIDEWAKTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDA0</accession>
    <name>A0A386PDA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MBOAT family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_00205</name>
        <name evidence="12" type="ORF">EI377_10685</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32981">
        <property type="protein sequence ID" value="AYE32981"/>
        <property type="gene ID" value="CP523_00205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61151">
        <property type="protein sequence ID" value="QAS61151"/>
        <property type="gene ID" value="EI377_10685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="458" mass="53503" checksum="34B7833A401AC6F5" modified="2018-12-05" version="1">MVFSSIVFIFRFLPLAVFIYFLTPKKYKNLAIFLLSLIFYSFGEPKYFPIIILSILIDFIVSNIIENNRDNKTLCNTMLTISIIFNLGLLIFFKYINFFIDNINFIFNIYIKNITLTLPLGISFYTFQTLSYTIDVYNKKIHAEKNIVDFGAFVALFPQLIAGPIVKYIDINNQIKNRKTSLEEIESGIQYFIIGLGKKVLIANNIGLLWDELNSLGFSNISTPLAWLGVLSFSLQIYFDFSGYSQMAIGIGKIFGFSLPNNFNYPYISRSMTEFWRRWHISLGSWFKEYVYIPLGGSRKSKKRTYFNLLIVWILTGFWHGAEYNFILWGIFFFILISIEKAGFINVLNNNKILSHIYVIIFLLIGFSIFSISNTAKLIEFLKRLFIFKGGLDYLYYLKNYGIILIIGCIFSMPIYKKINLKYKNIKTLKVIFMLIIFILSIAYLVDSSYNPFLYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDF1</accession>
    <name>A0A386PDF1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_00485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00626"/>
    <dbReference type="EnsemblBacteria" id="AYE33031">
        <property type="protein sequence ID" value="AYE33031"/>
        <property type="gene ID" value="CP523_00485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PocR" evidence="3">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="2">
        <location>
            <begin position="220"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="270" mass="30868" checksum="4FED8B60A28795BA" modified="2018-12-05" version="1">MENNRGLSDLIDVTLLQDIQDKLAEITGLAFNIVNFRGDPINKYSNFCSFCKAIRDTDEGFKLCRSANAHGGLEAAIRQKPYMFKCPAGLVDVAIPIIIDNQYVGAVFFGQVRTNAEDYLLSKESKNISRLLKKYPDFKKYYNDIGYIDYNKIKAIYSLVETIINQLINKSSLNKLEEEIIFNNIKLKKKEEENNILKSNLESMNFKFFQIPININVQLSILNSISNLALIEDAPKTQEMICTLAEIIRYSSKNINNQVILEEEIKNVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDQ6</accession>
    <name>A0A386PDQ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_00185</name>
        <name evidence="7" type="ORF">EI377_10710</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01195"/>
    <dbReference type="EnsemblBacteria" id="AYE32978">
        <property type="protein sequence ID" value="AYE32978"/>
        <property type="gene ID" value="CP523_00185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61154">
        <property type="protein sequence ID" value="QAS61154"/>
        <property type="gene ID" value="EI377_10710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="137"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="265"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE32978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="455" mass="52837" checksum="A0B19DDA8EE0DE4F" modified="2018-12-05" version="1">MNDSRNKTLKYKNYKYNDEIKNLLNINLTDSDLRKLDRIFKNYYELNSERGYKYLIKDLYILVQKQKLTTKQLSCVYDTGIRNIQIWLKELGLNRSIKKSKKIKPKVINTNPLSVKNSNSNTSDIASKFGIKVSETQKLPESLVDFLNYLETIKGKSLNTINGYKIDLILFFRFLKVYKGLITNPSLEFEEIEISDIDNSFIRKIKLTDIYAFLSFVEKQRANGTYARARKVATLKSYFKFLNIKAKIIDENPTLELESPKINKRHPVYLTLDQSIDLLNSLSVNDKNFHRDYCILTLFLNCGMRLSELCSIEINKIKGDTLTIVGKGNKERTVYLNEACLKAINNYMKVRDDSKVLNEDKKYLLLSSRNKPINKRTVEMLVKKHIENAGFRDAKYTPHKLRHTAATLMYKHGNVDIRSLQNILGHENISTTQIYTHVDDDILRDAVKSNPLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE09</accession>
    <name>A0A386PE09_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4091 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01685</name>
        <name evidence="4" type="ORF">EI377_12205</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00889"/>
    <dbReference type="EnsemblBacteria" id="AYE33261">
        <property type="protein sequence ID" value="AYE33261"/>
        <property type="gene ID" value="CP523_01685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61432">
        <property type="protein sequence ID" value="QAS61432"/>
        <property type="gene ID" value="EI377_12205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025150">
        <property type="entry name" value="GH123_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13320">
        <property type="entry name" value="DUF4091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788350" evidence="1">
        <location>
            <begin position="36"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="181"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="861" mass="98084" checksum="66913E7272002FCB" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE28</accession>
    <name>A0A386PE28_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ORF">CP523_01790</name>
        <name evidence="8" type="ORF">EI377_12310</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02393"/>
    <dbReference type="EnsemblBacteria" id="AYE33281">
        <property type="protein sequence ID" value="AYE33281"/>
        <property type="gene ID" value="CP523_01790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61452">
        <property type="protein sequence ID" value="QAS61452"/>
        <property type="gene ID" value="EI377_12310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01790"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="159" mass="17018" checksum="DCEEBC9453F06C7F" modified="2018-12-05" version="1">MKVAIFLGSKSDTEVMRGAANCLREFGVSYEAYILSAHRVPEKLTETLKKAEKSGCEVVIAGAGLAAHLPGVIASQTTMPVIGVPIKGAVEGLDALFSIVQMPKSIPVATVGINNSYNAGMLAVQILAVKDKAIREKLNKFRENMKEKFIEENAEGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE56</accession>
    <name>A0A386PE56_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06195</name>
        <name evidence="3" type="ORF">EI377_00670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679293.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000077.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02608"/>
    <dbReference type="EnsemblBacteria" id="AYE34090">
        <property type="protein sequence ID" value="AYE34090"/>
        <property type="gene ID" value="CP523_06195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59458">
        <property type="protein sequence ID" value="QAS59458"/>
        <property type="gene ID" value="EI377_00670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="253" mass="26827" checksum="0B8C6B175E591CD8" modified="2018-12-05" version="1">MSKLKGKVAIVTGGGKGIGYGVASAFANEGANIVITGRTLSTLEEAKGKLEKQYNIKVLPVVGDGSDEEAVKNVVNETIKTFGKLDILVNNAQVSKSGVLLVDHSKEDFDLAIYSGLYATFNYMKYSFPYLKEGPGKVINFASGAGISGRPGQSSYAAAKEGIRGLSRVAATEWGEYGINVNVVCPLAMTPGLEKWKQEYPEMYAANVKSIPLGRFGDATKDIGRVCVFLASDDSSYITGETISVQGGSGMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE61</accession>
    <name>A0A386PE61_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Arginase</fullName>
            <ecNumber evidence="3 10">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rocF</name>
        <name evidence="11" type="ORF">CP523_02015</name>
        <name evidence="12" type="ORF">EI377_12535</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-arginine = L-ornithine + urea</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678890.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00129"/>
    <dbReference type="EnsemblBacteria" id="AYE33321">
        <property type="protein sequence ID" value="AYE33321"/>
        <property type="gene ID" value="CP523_02015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61491">
        <property type="protein sequence ID" value="QAS61491"/>
        <property type="gene ID" value="EI377_12535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02015"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="PTHR43782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="301" mass="33269" checksum="2848E2B30948996F" modified="2018-12-05" version="1">MNISIIEMPLFYGCDNPGVENGPKILRENNLLDIFKKSHTVCDMGEVSIKHIDPSCKYTANDKMKYLDEVVRSNVELANKVYESLKNNSLPIVIGGDHSLALGSVAGSSKYYGEDLAVVWVDAHGDINTSETTPSGNIHGMPLSGSMGLGDESLINLYTKGKKVKPENVFILGARDLDKGELELIKEHKLNVWDIKCIKEKGLDFVLNELLQIIKDKKIKNIHFSFDIDCLDPCYVPGTGTPVEDGLTFIDGKKLIEIILGTNLVASIDFVEFNPALDKNNKTLETCLELLKIISNSLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE80</accession>
    <name>A0A386PE80_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Galactokinase</fullName>
            <ecNumber evidence="11">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galK</name>
        <name evidence="15" type="ORF">CP523_02120</name>
        <name evidence="16" type="ORF">EI377_12640</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674073.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00542"/>
    <dbReference type="EnsemblBacteria" id="AYE33341">
        <property type="protein sequence ID" value="AYE33341"/>
        <property type="gene ID" value="CP523_02120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61511">
        <property type="protein sequence ID" value="QAS61511"/>
        <property type="gene ID" value="EI377_12640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02120"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="14">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="116"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="283"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="11">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="387" mass="43281" checksum="7FA1EB814EEC3F06" modified="2018-12-05" version="1">MVKELVDKFIKVFGEKPQGNYFAPGRVNLIGEHTDYNGGNVFPCALTIGTYMIARKREDKLVRLHSKNFENSGIIEFNIDDLKNEKVHDWANYSKGVIWALKENGYTINNGFEGYVYGNIPNGAGLSSSASLELVTGVTLKDLFNLDVDMIDLVKFSQLAENKFIGVNCGIMDQFAIGMGKENCATLLDTNTLKYSYAPISLVDTSIVISNTNKRRGLADSKYNERRGQCEEALKELQKELKIKALGELSEEEFEKYKHIITDDINRKRAKHAVYENVRTLKAAEALKNNEIELFGELMNESHISLRDDYEVTGIELDTLVELAWKQEGVIGSRMTGAGFGGCTVSLVKNDDIDNFIKNVGAAYKEKIGYEADFYVVNIGDGARKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE95</accession>
    <name>A0A386PE95_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34353">
        <property type="protein sequence ID" value="AYE34353"/>
        <property type="gene ID" value="CP523_07900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009574">
        <property type="entry name" value="DUF1189"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06691">
        <property type="entry name" value="DUF1189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="263" mass="29756" checksum="DFB0AD684C66737B" modified="2018-12-05" version="1">MPILRRYVKVKLSFIKRMRISVANIRGYDVLVKECFNKVLMYILVLSLIIGLTLGISQAIFLGTFENIAINLLNEEDYKFEMKNGELNFEKSPYEKEEGSVISIFDTTKSVDDVESYRSIVVHKDMSVIFFKDGVVARSNGDQYIAKFKDIPFMPEYMNNDTLIDAVNKLSILKYIIIVVMVLVKYAAILVQGLIVSVAGILINKMKKTNLKYVDILKISLYAMTLPIILSLIIPIGAFTVVIATIYVIMVIKSLNNKNSNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB1</accession>
    <name>A0A386PEB1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06515</name>
        <name evidence="2" type="ORF">EI377_01000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677453.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34150">
        <property type="protein sequence ID" value="AYE34150"/>
        <property type="gene ID" value="CP523_06515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59518">
        <property type="protein sequence ID" value="QAS59518"/>
        <property type="gene ID" value="EI377_01000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="80" mass="9710" checksum="502EC437B3FB8025" modified="2018-12-05" version="1">MSKNVKSLNFIKNIRKTKKNRKYIRSRVIEYNKKQYEVEFLQLMKNGYEEMAQINLELSQLPFECEIANINEYEKWLCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC7</accession>
    <name>A0A386PEC7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_08075</name>
        <name evidence="8" type="ORF">CP523_11245</name>
        <name evidence="9" type="ORF">CP523_13560</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34385">
        <property type="protein sequence ID" value="AYE34385"/>
        <property type="gene ID" value="CP523_08075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34941">
        <property type="protein sequence ID" value="AYE34941"/>
        <property type="gene ID" value="CP523_11245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35372">
        <property type="protein sequence ID" value="AYE35372"/>
        <property type="gene ID" value="CP523_13560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08075"/>
    <dbReference type="KEGG" id="csep:CP523_11245"/>
    <dbReference type="KEGG" id="csep:CP523_13560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="412" mass="47639" checksum="0EF08655D47D042A" modified="2018-12-05" version="1">MTRKIDTNFDYNEEIKRCKTIDDVMGKNGLIQRLVKDVLENILEGEMEEHLGRNKYERVEVVDQTKKNYRNGYSRKNLRSSFGDVDLDVPRDRNAEFEPQIIKKYETVCTELDKKIISLYAKGMSTSDIQAEIEDLYGITISPSMVSKITDKVLASAAEWQNRALDKIYPIVYLDAMYFKVRSNGKIVNKAVYICLGYTMEGYKDILGIWVDEAEGAKFWLGICNDLKNRGVKEILIACMDGLKGLPQAIKTVFPSVNIQTCIVHQIRNSIKYIASKDKKAFMKDLKEVYKATTEELALAQLDNLKERWGDKYGIVIDSWYNNWSNLSTFFDFSPTIRKMIYTTNILEGFNRQIRKFTKVRVIFPTDESLNKCVYLATMEILEKWTQPIHNWGATLAELSIIFEDQLKDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEF8</accession>
    <name>A0A386PEF8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_08290</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674739.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01599"/>
    <dbReference type="EnsemblBacteria" id="AYE34425">
        <property type="protein sequence ID" value="AYE34425"/>
        <property type="gene ID" value="CP523_08290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="14">
        <location>
            <begin position="4"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="420"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="542" mass="63366" checksum="694E96EEA35866D2" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH1</accession>
    <name>A0A386PEH1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_08330</name>
        <name evidence="5" type="ORF">EI377_03075</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674763.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01607"/>
    <dbReference type="EnsemblBacteria" id="AYE34433">
        <property type="protein sequence ID" value="AYE34433"/>
        <property type="gene ID" value="CP523_08330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59836">
        <property type="protein sequence ID" value="QAS59836"/>
        <property type="gene ID" value="EI377_03075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="279" mass="30299" checksum="32B831C81EECA092" modified="2018-12-05" version="1">MGNCSTCPSKDKCTSKTNGEPSCGKVTPNYGIIKNIIGVISGKGGVGKSTVTGILASTLRKKGYNVGVLDADITGPSMPRFFGINEKRAMMQPIGETGVKYFPVKTESGIEVMSVNLLIPNEDDPVIWRGPMATGVLSQLFTDTNWGELDYLLIDMPPGTSDITLTIMQSFPLTELIIVSTPQDMVSMIVKKGIVMANKMGVPVRGVIENMAYITCPGCDTKIKVFSKKSAEEHAEYLELPLLGELPINLDLTEALEQGKAEEYVRNNDLYSLIFEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ8</accession>
    <name>A0A386PEJ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00765</name>
        <name evidence="4" type="ORF">EI377_11260</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674631.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02367"/>
    <dbReference type="EnsemblBacteria" id="AYE33086">
        <property type="protein sequence ID" value="AYE33086"/>
        <property type="gene ID" value="CP523_00765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61255">
        <property type="protein sequence ID" value="QAS61255"/>
        <property type="gene ID" value="EI377_11260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="210"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="505" mass="56957" checksum="8439F846DBB20F23" modified="2018-12-05" version="1">MSIEIISATHNGLDGILVNVEVDITKGLPSFNLVGLPDTSVKEAKERVKSAILNSGFKFPLGRITVNLAPAYIKKIGSLLDLPIAVGILMASNQIDRSDLKDFIMFGELSLRGDLKGIKGAVPIIFEGDNKNKSSFIFPFENLKEVRCFNLGNFYPFNNLKEVVSFINNNDLLPCDNTDIKDKKEDYLIDYSQIIGHRSSKRAMEIVASGKHNIILFGSPGSGKTMLAKALPSILPPLSNQEKKEIAKIYSVSGLLKDEDFIKRPFRNPHHTITKAALVGGGKEIKAGEVTLAHNGVLFLDEILEFKKEILEVLREPLEDKVININRLNGNYLFPSNFLLVGAFNPCPCGFGGIEDDKCICSENEKRRYLNKLSRALLDRIDLLNFVPRLKYEDISTTNDKITSKIMKERVLKAIDIQKNRYKDTVYNYNSELKGNELEEYCNINRSTKSLLEFYYNKYNLTTRGYFKMIKVARTIADLDNSYEVLDYHILEAIGYRKNVNGDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN1</accession>
    <name>A0A386PEN1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05165</name>
        <name evidence="9" type="ORF">EI377_15725</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01822"/>
    <dbReference type="EnsemblBacteria" id="AYE33907">
        <property type="protein sequence ID" value="AYE33907"/>
        <property type="gene ID" value="CP523_05165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62059">
        <property type="protein sequence ID" value="QAS62059"/>
        <property type="gene ID" value="EI377_15725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="104"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="503"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="603" mass="66083" checksum="714B189D0257D18F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW8</accession>
    <name>A0A386PEW8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">fliQ</name>
        <name evidence="10" type="ORF">CP523_02540</name>
        <name evidence="11" type="ORF">EI377_13075</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673934.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00459"/>
    <dbReference type="EnsemblBacteria" id="AYE33418">
        <property type="protein sequence ID" value="AYE33418"/>
        <property type="gene ID" value="CP523_02540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61592">
        <property type="protein sequence ID" value="QAS61592"/>
        <property type="gene ID" value="EI377_13075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="9666" checksum="B8610455FE19AC71" modified="2018-12-05" version="1">MSENLVIGVVKDALYTSLKVAGPILIVAILIGLIISIFQATTQIQEQTLTFVPKLIGIAAVGLILGSWMLHTVVSFTERIFELIIRIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ6</accession>
    <name>A0A386PEZ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">fliW</name>
        <name evidence="4" type="ORF">CP523_02695</name>
        <name evidence="5" type="ORF">EI377_13220</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliW family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676948.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00945"/>
    <dbReference type="EnsemblBacteria" id="AYE33448">
        <property type="protein sequence ID" value="AYE33448"/>
        <property type="gene ID" value="CP523_02695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61619">
        <property type="protein sequence ID" value="QAS61619"/>
        <property type="gene ID" value="EI377_13220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="139" mass="15925" checksum="55C0FB0291472705" modified="2018-12-05" version="1">MEIISPVHGKIVYSESDIINFEKGIPGFDNLKKYVIKEVEETNFSLLQSIEDSDLAFIITSPFSVEENYEIKLSEEIIKNLHVQSPNDVMLYVIVTLNSDVSKATVNLKAPLIINIKDRNGEQFIVDREEYKIRHPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF05</accession>
    <name>A0A386PF05_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_03575</name>
        <name evidence="12" type="ORF">EI377_14100</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677740.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02230"/>
    <dbReference type="EnsemblBacteria" id="AYE33611">
        <property type="protein sequence ID" value="AYE33611"/>
        <property type="gene ID" value="CP523_03575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61775">
        <property type="protein sequence ID" value="QAS61775"/>
        <property type="gene ID" value="EI377_14100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="225" mass="26577" checksum="8AAA66C8214B3B0C" modified="2018-12-05" version="1">MNNKIYIIEDEEKIRLELSTFLNRYGYDTKYSIDFENIIEEVLNYKPHLILLDINLPYYDGYYICREIRKKSEIPIIVVTSRDSEVDELMSMNFGADDFVTKPYNTQILLARISSIIKRTYNNNQADIFEYMELKYNLSTSELEYKGEVIDLTKNESRIIYTLIKNNEKIVSRNEIIQVLWQSDEFVDDNTLTVNINRLRRKIEGIGAVGYLQTKRGQGYILKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF22</accession>
    <name>A0A386PF22_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_01710</name>
        <name evidence="11" type="ORF">EI377_12230</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677348.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02409"/>
    <dbReference type="EnsemblBacteria" id="AYE33266">
        <property type="protein sequence ID" value="AYE33266"/>
        <property type="gene ID" value="CP523_01710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61437">
        <property type="protein sequence ID" value="QAS61437"/>
        <property type="gene ID" value="EI377_12230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="188"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="471" mass="53979" checksum="BD0357AE628514B0" modified="2018-12-05" version="1">MKLKNKLFINFGILFFITLNISGCFLIKSTFNTSIQKAIDESFREYAVIYSNIKSGENLNNLFLTTEEIISIKSDNYLSIIQNPSINLEFRTKNNKIIYSSNSNNFNLPNKLFSFDNDKANYIILNFNKTNNLIISKPISFNNQNFSFTYINNIDSLYNTQNNNIIILFELNFLFILIFLLIIYLISSDITKPLSILSNNIDEIIKGNFNKKLSYSSDIKELNTISTNFNLMSEEIKNKIALLSKENLSKQRFINNLTHEIKTPLTSIIGYSSLIINKKIKDIDLIHKSFETIYNDGKRIESLTTNLIKLITLDKSNLDIEDVHVLSVLEDIENTIKIKLIEHNIDFSIHGFDFIIKTDKYLLTTLLSNFIDNSIKAISNHNTLEKKIIIVLNKNSLVIKDSGIGIPKEDLDKIFEPFYMINKSRVHSIGGFGLGLAICSKIIEILNIKFYISSIPNKGTTIKLIFKGDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF35</accession>
    <name>A0A386PF35_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF871 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05975</name>
        <name evidence="4" type="ORF">EI377_00455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675065.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01897"/>
    <dbReference type="EnsemblBacteria" id="AYE34047">
        <property type="protein sequence ID" value="AYE34047"/>
        <property type="gene ID" value="CP523_05975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59419">
        <property type="protein sequence ID" value="QAS59419"/>
        <property type="gene ID" value="EI377_00455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008589">
        <property type="entry name" value="MupG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043894">
        <property type="entry name" value="MupG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043797">
        <property type="entry name" value="MupG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38435">
        <property type="entry name" value="PTHR38435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05913">
        <property type="entry name" value="DUF871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19200">
        <property type="entry name" value="DUF871_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF871_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF871" evidence="1">
        <location>
            <begin position="247"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="364" mass="42031" checksum="95EB28DB8520F7E1" modified="2018-12-05" version="1">MRKLGISIYPEKTSEKEIYDYIDKASKYGFSRIFSCLLSVNDTKENIIKKFKGINEYAKTKGFEIIVDVSPRVFDELGVSYKDLTFFKEIGADGLRLDAGYTGSEESLMTYNDEGLKIEINMSNNTNYIDTIMDYKPNKENLIACHNFYPHRYSGLNFNHFIKCTERFKKYGLRTAAFVTSQNEETFGPWPVTDGLPTLEIHRNLPIDVQAKHLIALGNIDDIIISNCYPTEAELKSLASIRRDMVTFDIILNEKTPEVEKKILFEEKHFNRGDFSDNLIRSTQSRVKYKGHKFELFNAPEIIKKGDVVIESSEYGHYAGELQIALKDMVNSGKSNVVAHIKEDELFILDFIEPWQKFNFKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF45</accession>
    <name>A0A386PF45_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04930</name>
        <name evidence="8" type="ORF">EI377_15430</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01691"/>
    <dbReference type="EnsemblBacteria" id="AYE33864">
        <property type="protein sequence ID" value="AYE33864"/>
        <property type="gene ID" value="CP523_04930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62007">
        <property type="protein sequence ID" value="QAS62007"/>
        <property type="gene ID" value="EI377_15430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033789522" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1272"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="672"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="882"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1302" mass="145892" checksum="8A452F5F4927699D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA9</accession>
    <name>A0A386PFA9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Diacylglycerol kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_02200</name>
        <name evidence="14" type="ORF">EI377_12720</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674040.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00527"/>
    <dbReference type="EnsemblBacteria" id="AYE33356">
        <property type="protein sequence ID" value="AYE33356"/>
        <property type="gene ID" value="CP523_02200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61526">
        <property type="protein sequence ID" value="QAS61526"/>
        <property type="gene ID" value="EI377_12720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="12">
        <location>
            <begin position="133"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="25267" checksum="ECF24802BA489B99" modified="2018-12-05" version="1">MKLKKVVESFNYAINGIIDTVRTQRNMKIHLVAALCVLLACFFFDISKIEFLLLAITITLVIAAELINTAIEAAIDMSTNYYHPLAKISKNAAAGGVLVTAINAMIVGYIVFGDKISDFSYTVVHKVKNSEPYTIFIVLVFVTIATVIVKAIFGEGTPLKGGMPSGHSALAFSIATAISLITEEPICILLSYLMAFITAQSRVDSEVHSILEVIVGGIFGTLLTLLIFTIFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB6</accession>
    <name>A0A386PFB6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01320</name>
        <name evidence="3" type="ORF">EI377_11820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675566.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33192">
        <property type="protein sequence ID" value="AYE33192"/>
        <property type="gene ID" value="CP523_01320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61362">
        <property type="protein sequence ID" value="QAS61362"/>
        <property type="gene ID" value="EI377_11820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="110" mass="12684" checksum="EBF2F076843B2827" modified="2018-12-05" version="1">MLLKYILLVYGFCEFLFGVFIWFSKKESLPKMMVESFSVLSNDVNYENIKDKKAFSRWIGELIMLGGALYTFLASSSIFFGVSLIAVIAFIVLIESVFFRMVIKGYKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB9</accession>
    <name>A0A386PFB9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03335</name>
        <name evidence="4" type="ORF">EI377_13850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677209.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02117"/>
    <dbReference type="EnsemblBacteria" id="AYE33568">
        <property type="protein sequence ID" value="AYE33568"/>
        <property type="gene ID" value="CP523_03335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61731">
        <property type="protein sequence ID" value="QAS61731"/>
        <property type="gene ID" value="EI377_13850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017220">
        <property type="entry name" value="Sulphite_reductase_assimil"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037487">
        <property type="entry name" value="Sulfite_red_assimil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="85"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="24613" checksum="4AD06748B7B26A00" modified="2018-12-05" version="1">MSNTYGNLQKIRDGVRTYGITPHLPGGFVTPDMLEKIANIARKYNGVLKITSGQRILITNLKDSDLPNIWEELEMKPAVKCQNSVKNVEMCPAGFCKRAKYNTIGIGMRLSNKYQWMEMPCRTKIGVAGCKNACASTYSKDVGIIADKTGLMVIAGGSAGYNPRVADIIEVDLNEEQALRLVDSIFEYYKNNADAGEKLSFFIERIGIEKFKEEVIKISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD3</accession>
    <name>A0A386PFD3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">High-affinity heme uptake system protein IsdE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Iron-regulated surface determinant protein E</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Staphylococcal iron-regulated protein F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">isdE</name>
        <name evidence="10" type="ORF">CP523_10325</name>
        <name evidence="11" type="ORF">EI377_05105</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674275.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01430"/>
    <dbReference type="EnsemblBacteria" id="AYE34765">
        <property type="protein sequence ID" value="AYE34765"/>
        <property type="gene ID" value="CP523_10325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60164">
        <property type="protein sequence ID" value="QAS60164"/>
        <property type="gene ID" value="EI377_05105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019957">
        <property type="entry name" value="ABC_transptr_haem-bd_IsdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03659">
        <property type="entry name" value="IsdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362739" description="High-affinity heme uptake system protein IsdE" evidence="8">
        <location>
            <begin position="28"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="9">
        <location>
            <begin position="40"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="293" mass="32170" checksum="C8DBCE0EADADCC0C" modified="2018-12-05" version="1">MTMKRLLSIIIVVLVMTSFTGCYGPKGENKDIQTKKDGEVVVATSVAVTEILDKLGVSLTGVPTTNYTLPESTKDSVKVGNPMNPDLEKIKSLNPTVVVSVDTLGDDFKNTFIENNIPSEFVTLTSLDGLKESIKKLGDKFNKKEEADNLLNEISDKESEIAKKNYGKEKEKVLIIFGAPGSMMIGTSKCYVGNLVDIVGGKNIVENNSTSFVQLNIEEILKSNPDKILVMTHGDPEEAKNMVSKELKNNPMWQKLSAVKEDKVHYLDSKKFGMSANLKVIEALGELDSILHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF2</accession>
    <name>A0A386PFF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05560</name>
        <name evidence="2" type="ORF">EI377_00205</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33974">
        <property type="protein sequence ID" value="AYE33974"/>
        <property type="gene ID" value="CP523_05560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59371">
        <property type="protein sequence ID" value="QAS59371"/>
        <property type="gene ID" value="EI377_00205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="184" mass="21570" checksum="E5AD8614188653D9" modified="2018-12-05" version="1">MKIWRVDKNVDDYSGFYLKNEDDKNILEEKLDKGDLVSNWNELEVEVHEADKPIGDCPHLWSGGYSLIVSERGKEIISNNYKNYIQFLSLNYSQENQKFYVLNNLNIIDCVDYNKSELEILMNKYIVDVKKYVFNENAKKAPIFKIYLDGVIKISTFVNNDFKNLIEDSGLEGFKFTEVFDFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG1</accession>
    <name>A0A386PFG1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein CP523_02480</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02480</name>
        <name evidence="4" type="ORF">EI377_13015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00471"/>
    <dbReference type="EnsemblBacteria" id="AYE33406">
        <property type="protein sequence ID" value="AYE33406"/>
        <property type="gene ID" value="CP523_02480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61580">
        <property type="protein sequence ID" value="QAS61580"/>
        <property type="gene ID" value="EI377_13015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="11090" checksum="97F570BF587C5EBE" modified="2018-12-05" version="1">MIILTTNDFPGKNIKEVKGIVQGSTVQCKHLGRDIGAGFRNLVGGEMKAYKDMLDDSRKIAIERMVEEGKLLGANAILGFKLMSSTVAAGASEMVAYGTAVIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR5</accession>
    <name>A0A386PFR5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_04135</name>
        <name evidence="12" type="ORF">EI377_14655</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02757"/>
    <dbReference type="EnsemblBacteria" id="AYE33718">
        <property type="protein sequence ID" value="AYE33718"/>
        <property type="gene ID" value="CP523_04135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61873">
        <property type="protein sequence ID" value="QAS61873"/>
        <property type="gene ID" value="EI377_14655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788362" description="Beta-N-acetylhexosaminidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1721"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="185"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1670"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1526"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1632"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1673"/>
            <end position="1715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1747" mass="194100" checksum="8D8635422F7873E6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW4</accession>
    <name>A0A386PFW4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="8">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">leuS</name>
        <name evidence="14" type="ORF">CP523_11265</name>
        <name evidence="15" type="ORF">EI377_06075</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02810"/>
    <dbReference type="EnsemblBacteria" id="AYE34945">
        <property type="protein sequence ID" value="AYE34945"/>
        <property type="gene ID" value="CP523_11265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60339">
        <property type="protein sequence ID" value="QAS60339"/>
        <property type="gene ID" value="EI377_06075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="12">
        <location>
            <begin position="40"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="219"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="414"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="662"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="576"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS60339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="816" mass="92784" checksum="7FC8E288DBF86849" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY2</accession>
    <name>A0A386PFY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09955</name>
        <name evidence="7" type="ORF">EI377_04740</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00320"/>
    <dbReference type="EnsemblBacteria" id="AYE34700">
        <property type="protein sequence ID" value="AYE34700"/>
        <property type="gene ID" value="CP523_09955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60101">
        <property type="protein sequence ID" value="QAS60101"/>
        <property type="gene ID" value="EI377_04740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="305"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="415" mass="45044" checksum="C926872EEC95F223" modified="2018-12-05" version="1">MSDENKIYDVDNYEHVNIEKESEFNQEEVKNNYEKINDSKNEDNNIKFSNINENVNKKKKKRGVKNIALMLVIGILGGAVGGGATYYAVKSINGDGNVVSTPNPPTFKADENEALTKIQAFEKVAPAVVIVSTKGVQNYGGFIPKEVEGIGSGFIINEEGYILTNYHVIEGAQEVTVTLSDKREVKAKVVNYDQNQDVAMLKIVDNIKVPAVVELGDSDALKAGEEVLAIGTPLSKEFSQTVTGGLVSALNRNIETSSGVKLNLIQTDTAINPGNSGGPLINTKGQVIGINTLKISGTAEGIGFAIPINEVKGRIESLSKPILNLGVSIREVDENLAKQYEMPQGLYVVEVTQFSPAEKAGIKGGDVITKFDGKRIKTFEELKEIRDSKKEGDTVRVEIVRNQETITVEVELTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG94</accession>
    <name>A0A386PG94_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate phosphodiesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">HDOD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11915</name>
        <name evidence="4" type="ORF">EI377_06735</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673451.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02941"/>
    <dbReference type="EnsemblBacteria" id="AYE35063">
        <property type="protein sequence ID" value="AYE35063"/>
        <property type="gene ID" value="CP523_11915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60456">
        <property type="protein sequence ID" value="QAS60456"/>
        <property type="gene ID" value="EI377_06735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HDOD" evidence="2">
        <location>
            <begin position="203"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="407" mass="47317" checksum="3E948A449345DFC4" modified="2018-12-05" version="1">MDIFIARQAIYNKNEKVVAYELLYRSSLDNKFDSSVKPEEATYKVIQNISSFGLDKLTNNKMALVNFPEEVINSNMATLLPKEKVIIEVLENVKPTKEVIDNLRFLKRKGYYVALDDVSNLNQVMKFINIVDIIKVDFKLSTKEERKEIANFFMKNNFKLYNIKLLAEKIESKADFKEAIELNFKYFQGFYFSTPSVIIGEDIAVRNITIFNVLIELLKEEFDLSRIESIIISDVALSYKFLRFINSAYFSFVQEIDSIRQGIMLIGMEELRKWLSIVSVVEMRLSKSEEYANNTVIRAKFCEEVMAKINYKEKGNAFMVGLFSDLHVMMRKDIQSVVDELPVSFNVKEALLGKDNILRYILNLTLAYEELNTDLVYKISNRVGLNIDNLGQIYLNTIEWAKRINTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA6</accession>
    <name>A0A386PGA6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_07275</name>
        <name evidence="11" type="ORF">EI377_02025</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673749.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01072"/>
    <dbReference type="EnsemblBacteria" id="AYE34264">
        <property type="protein sequence ID" value="AYE34264"/>
        <property type="gene ID" value="CP523_07275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59670">
        <property type="protein sequence ID" value="QAS59670"/>
        <property type="gene ID" value="EI377_02025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="254"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="467" mass="53491" checksum="18F6B8F54BA046B2" modified="2018-12-05" version="1">MKNLGIKWKIFSYLLCFCAILLSVLWIFQTVLLSSFYRSIKVKETKKTVKEIVSLIENNEDLMPVASELASRNESYIEVMTSEGITLVSVGDMKNRIQMDKKHILLSKLKNGEYVEYYNKKLEPHNMYPQNDFKDRGPIESIMYIKEASNGQIVLINSMISPVNATVNTLRYQLYIITGLMILFSIVFAIIIAHRVSKPIEKLNKSAKYLAKGKYDINFTHEGYREIGELSDTLNVASIELNKVESLRRELLANISHDLRTPLSLIYSYAEVMHDFPEDITSEQTQTIMDEIERLSSLVNDVLDISQLESGNQSLTMNRFNLTKNLEATLERIEELVRSKGYELEFSAEKEVWVEGDEIKLTQVFYNLLINAINYTGEDKKVSVRQLVDSDSVRIEVIDTGDGIANEDIPYIWERYYKVDKNHKRAITGTGLGLSIVKKVMEMHGGNYGVESEQGKGSTFWFTLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD5</accession>
    <name>A0A386PGD5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12300</name>
        <name evidence="7" type="ORF">EI377_07125</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673610.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03016"/>
    <dbReference type="EnsemblBacteria" id="AYE35135">
        <property type="protein sequence ID" value="AYE35135"/>
        <property type="gene ID" value="CP523_12300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60527">
        <property type="protein sequence ID" value="QAS60527"/>
        <property type="gene ID" value="EI377_07125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="34879" checksum="AFA114F7E2ADB09C" modified="2018-12-05" version="1">MSIIEVKNITKRFNDKLVLDNVSYEVKEGEIFGFIGPNGAGKSTLISIMTSLLTPDNGTIKICGYDILKEPIKAKECIGYVPQELALMEELTAYDNLEFFGALYGLKGKLLKERIAEALKVTGLGETKKQKVKKFSGGMKRRLNIAVAILHHPKVLILDEPTVGVDPQSRNHIFSFIKNIGKEWGTTVIYTSHYMEEIEELCQRVFIIDLGKEVAYGYREEIKASVFSNNKVIIEANNINGEILRQLDSAEGINKVVENENKITLTIGSNFKLTNVLSLIEKSDVNIKKISYEEVKLEDVFLSLTGKTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH0</accession>
    <name>A0A386PGH0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">nusG</name>
        <name evidence="11" type="ORF">CP523_08905</name>
        <name evidence="12" type="ORF">EI377_03660</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678828.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01780"/>
    <dbReference type="EnsemblBacteria" id="AYE34527">
        <property type="protein sequence ID" value="AYE34527"/>
        <property type="gene ID" value="CP523_08905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59929">
        <property type="protein sequence ID" value="QAS59929"/>
        <property type="gene ID" value="EI377_03660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 7 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="9">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="10">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="19720" checksum="CB9297747DC76563" modified="2018-12-05" version="1">MSDRARWYVVHTYSGYENKVKANLEKTIENRNLQSLLQDIQVPMEEVIEEKDGKQKISLKKKFPGYVLVKMLMTDESWYVVRNTRGVTGFVGPASKPVPLTDEEVESMGVIEAPIEIDLEVGESIRVISGPLKEFVATIQEINLEKRKIKASIDMFGRETLAELDFTQVEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN4</accession>
    <name>A0A386PGN4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_02110</name>
        <name evidence="12" type="ORF">EI377_12630</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674078.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00544"/>
    <dbReference type="EnsemblBacteria" id="AYE33339">
        <property type="protein sequence ID" value="AYE33339"/>
        <property type="gene ID" value="CP523_02110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61509">
        <property type="protein sequence ID" value="QAS61509"/>
        <property type="gene ID" value="EI377_12630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02110"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="39451" checksum="5AC599C9B884343D" modified="2018-12-05" version="1">MKITSNIVGKFSSEEVISYEIRNSKGFGINVLNYGGIITDVIAPDKNGNLENVVMKYKDMNIYEENPSYYGALIGRTAGRIFAGEVKLNNKILKLNKNYGFNQGHGGNIGFDKKLMKAKVKILEDKAFVELKYFSPNNEEGYPGNLNIAVRYTVTEDNTFKISYKGVSDEDTLLNLTNHSYFNLSGNKNETILDHHLYIDSDFLVELDETQAPTGNIININGSAFDFTIPKLIGRDIEEDDLQLRIGQGYDHPWILNGGKQVKLRLYHKPSGRVMDVYTNHKSVVLYSLNFPDDKIVEGGYLPKRRGAIAIETQSPPIGKNSCFANHSILKKDEEYSKETIYKFDIMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ1</accession>
    <name>A0A386PGQ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YqfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqfD</name>
        <name evidence="2" type="ORF">CP523_02215</name>
        <name evidence="3" type="ORF">EI377_12735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674035.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00524"/>
    <dbReference type="EnsemblBacteria" id="AYE33359">
        <property type="protein sequence ID" value="AYE33359"/>
        <property type="gene ID" value="CP523_02215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61529">
        <property type="protein sequence ID" value="QAS61529"/>
        <property type="gene ID" value="EI377_12735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010690">
        <property type="entry name" value="YqfD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06898">
        <property type="entry name" value="YqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02876">
        <property type="entry name" value="spore_yqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="378" mass="43127" checksum="9A48FF2420B7D2EB" modified="2018-12-05" version="1">MGFDFLKISKITVEVSILNPERLLNILWTKRVNILNVKRVDIATVLIQIEYEDYDILKDAVKKLGGKMKIVGSGGFLFFLGKLKRKSSLVIGGILFVMIIFYLSTFVWRVEINTKKNVSPYELRQQLYAIGIKPGIKKSNINAKEIEKKIEDVNSDVLWLRARVEGSTLKVYIEEKVNPPKQQEKKMGNLVAKMDGQIKRIYAFSGRAAVPIGTMIRAGEVVIEGINGKEEEPYEVPPEGVVMANTFYEKDMKVQIDGSKLERNGKRDNDIYLNIFGKKIYLKKAIKDFKHYDKIEESGKVFNKVIYFEREETPVKLSKEEAVENSIRELGESLLNELTREAVIVDKIVNTEEDGQGNLMVKVIFVVEQNIVDNTPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR7</accession>
    <name>A0A386PGR7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04730</name>
        <name evidence="3" type="ORF">EI377_15240</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01725"/>
    <dbReference type="EnsemblBacteria" id="AYE33826">
        <property type="protein sequence ID" value="AYE33826"/>
        <property type="gene ID" value="CP523_04730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61972">
        <property type="protein sequence ID" value="QAS61972"/>
        <property type="gene ID" value="EI377_15240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="106" mass="12100" checksum="E2004FCAAACD1598" modified="2018-12-05" version="1">MPRKDSIDIGELTDSAFYILSSVIEEKHGYLIMKTIENLTNNEVTIGPASLYTTLKKLLSADLVELSSGTDENKKVYKITNKGREMLIKEIERKKQMVKFAENFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU4</accession>
    <name>A0A386PGU4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13205</name>
        <name evidence="2" type="ORF">EI377_08050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AYE35305">
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        <property type="gene ID" value="CP523_13205"/>
    </dbReference>
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        <property type="gene ID" value="EI377_08050"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046242">
        <property type="entry name" value="DUF6275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19791">
        <property type="entry name" value="DUF6275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="10579" checksum="8B283C37776229BD" modified="2018-12-05" version="1">MNEKEFLEWCKQEVCNYTNKHLDKTDKKEITTDDVFMVWSCKTLQNNKALLSTTLFDGMYYECTYNGDKKEMYVDAYKKWENYKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW0</accession>
    <name>A0A386PGW0_CLOSE</name>
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        </submittedName>
    </protein>
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                <person name="Seyboldt C."/>
            </authorList>
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                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">VAT12</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="STRING" id="1504.GCA_900092375_01955"/>
    <dbReference type="EnsemblBacteria" id="AYE35313">
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        <property type="gene ID" value="CP523_13245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60700">
        <property type="protein sequence ID" value="QAS60700"/>
        <property type="gene ID" value="EI377_08095"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="160" mass="17541" checksum="7794C9BFC8ADDD9D" modified="2018-12-05" version="1">MAIRKRKIQANYLKVGETFELLGTGFTELNESPSAQTTSKRYINQSSASQSITGYEWSTSFNADQIASEKAIDHIRDIGEMQKTGADTETEYLIVDLDKPDTTSGFRARKFDVAISVDSFDDNDGELGISGSFLGISDPVEGTFDTAAKTFKKGFTPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH75</accession>
    <name>A0A386PH75_CLOSE</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03130</name>
        <name evidence="2" type="ORF">EI377_13645</name>
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    <organism evidence="1 3">
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    <reference evidence="1" key="1">
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="QAS61692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33529">
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        <property type="gene ID" value="CP523_03130"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61692"/>
        <property type="gene ID" value="EI377_13645"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024218">
        <property type="entry name" value="DUF3867"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12983">
        <property type="entry name" value="DUF3867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="21668" checksum="CBF14287205381D4" modified="2018-12-05" version="1">MDRVIDFNELKNRVNDKDIDKFESYIYSLYYDMSAGKLTMADFTKEMMSYMEKNNISQDKFLKMQTKLMERYGFDASSLEEQVKALGLDKIAGASTDVEKIRKTMSFQEKYKDKMQMKAVSTYSINNEKNNVGILLEEENVILKSFGKIDLADLELNEFLCSYKKVVDNKQLKISICENVKEYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG0</accession>
    <name>A0A386PHG0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05915</name>
        <name evidence="3" type="ORF">EI377_00405</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
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    <reference evidence="2" key="2">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675036.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34036">
        <property type="protein sequence ID" value="AYE34036"/>
        <property type="gene ID" value="CP523_05915"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59409"/>
        <property type="gene ID" value="EI377_00405"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="271" mass="31504" checksum="685C4EBD9E163E3E" modified="2018-12-05" version="1">MKILRTDLKRALISKEMLLSIILGLLLILLAIIFEPIRSAFNTYFSTSKDLDIEIKKQLIGNSLNKVTLWNFGNYFYSNLIPLICCIPFTTEYLKDKKNGFNKYLIIRSNYKSYIRSKIITTFISGFVPLFIISIITLIFINIFNSGDEFRSIFYYNTLLSDLSTNNFNTFALIYGVISSFMGGTYALIGLAISTFSDKIFVAFISPFFLYYTGTYIMSILEITPLIPNLITYFYRYQSCKFSYIVMQLLILFSLSLLIFLKKTYWSKIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI4</accession>
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        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CP523_09530</name>
        <name evidence="3" type="ORF">EI377_04275</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676664.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02612"/>
    <dbReference type="EnsemblBacteria" id="AYE34644">
        <property type="protein sequence ID" value="AYE34644"/>
        <property type="gene ID" value="CP523_09530"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60043"/>
        <property type="gene ID" value="EI377_04275"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="355" mass="40657" checksum="B9586C5CB6994203" modified="2018-12-05" version="1">MIYGLILAGGKGTRLYPLSRANKPKQFLKVINNKSFLENTVERIIPLIKKENIYVVTNQDYQDKIRLELTDINKENIFTEPENKETATCIGLSAVKLLKKDGDAVIVVLPSDHHIDGQKDYIETLSQAVDIANRKRGIVTLGIEPNRPETGYGYIEMGQRVPGERPSYKVARFTEKPNTEVAKDFLLKGTYLWNSGMFVFRADVILREIEKYLPDLHKSLMEIYKHLGEDDEEEVIREQYNLIDGISIDFGVMQKTRKAYVIKSDFIWDDIGSFSALSRYKDIFRDSNSKNNIYLQECENCSIFGDKNLIIGLGVKDLVIVDAGDVILVMDKNKDQEIKHLLNDLSKEEEYGKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY7</accession>
    <name>A0A386PHY7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">greA</name>
        <name evidence="12" type="ORF">CP523_08650</name>
        <name evidence="13" type="ORF">EI377_03400</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674909.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01671"/>
    <dbReference type="EnsemblBacteria" id="AYE34488">
        <property type="protein sequence ID" value="AYE34488"/>
        <property type="gene ID" value="CP523_08650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59890">
        <property type="protein sequence ID" value="QAS59890"/>
        <property type="gene ID" value="EI377_03400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="10">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="160" mass="17893" checksum="54564D92E76B583D" modified="2018-12-05" version="1">MSESKKFLMTYEGVKKLEDELEYLKTVKRKEITEKIKVALGYGDLSENSEYDEAKNEQAFTEGRIIQLENMLKNASVVDESEIPTDKVSVGSIVKVKDYEFDEEVEYSIVGSAEADPMNFKISNESPVGSALIGKKVGEIVEVSVPSGVNKFEILGIRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI01</accession>
    <name>A0A386PI01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00010</name>
        <name evidence="2" type="ORF">CP523_01865</name>
        <name evidence="3" type="ORF">CP523_02990</name>
        <name evidence="4" type="ORF">CP523_03115</name>
        <name evidence="5" type="ORF">CP523_03880</name>
        <name evidence="6" type="ORF">CP523_03965</name>
        <name evidence="7" type="ORF">CP523_06630</name>
        <name evidence="8" type="ORF">CP523_06640</name>
        <name evidence="9" type="ORF">CP523_08965</name>
        <name evidence="10" type="ORF">CP523_09170</name>
        <name evidence="11" type="ORF">CP523_10205</name>
        <name evidence="12" type="ORF">CP523_12715</name>
        <name evidence="13" type="ORF">CP523_14150</name>
        <name evidence="14" type="ORF">CP523_15600</name>
        <name evidence="15" type="ORF">EI377_01345</name>
        <name evidence="16" type="ORF">EI377_03915</name>
        <name evidence="17" type="ORF">EI377_04350</name>
        <name evidence="18" type="ORF">EI377_04480</name>
        <name evidence="19" type="ORF">EI377_04490</name>
        <name evidence="20" type="ORF">EI377_04965</name>
        <name evidence="21" type="ORF">EI377_05630</name>
        <name evidence="22" type="ORF">EI377_06050</name>
        <name evidence="23" type="ORF">EI377_08210</name>
        <name evidence="24" type="ORF">EI377_08875</name>
        <name evidence="25" type="ORF">EI377_09055</name>
        <name evidence="26" type="ORF">EI377_14305</name>
    </gene>
    <organism evidence="14 27">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 28" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 28">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677279.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32944">
        <property type="protein sequence ID" value="AYE32944"/>
        <property type="gene ID" value="CP523_00010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33295">
        <property type="protein sequence ID" value="AYE33295"/>
        <property type="gene ID" value="CP523_01865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33503">
        <property type="protein sequence ID" value="AYE33503"/>
        <property type="gene ID" value="CP523_02990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33526">
        <property type="protein sequence ID" value="AYE33526"/>
        <property type="gene ID" value="CP523_03115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33668">
        <property type="protein sequence ID" value="AYE33668"/>
        <property type="gene ID" value="CP523_03880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33684">
        <property type="protein sequence ID" value="AYE33684"/>
        <property type="gene ID" value="CP523_03965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34172">
        <property type="protein sequence ID" value="AYE34172"/>
        <property type="gene ID" value="CP523_06630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34174">
        <property type="protein sequence ID" value="AYE34174"/>
        <property type="gene ID" value="CP523_06640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34539">
        <property type="protein sequence ID" value="AYE34539"/>
        <property type="gene ID" value="CP523_08965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34580">
        <property type="protein sequence ID" value="AYE34580"/>
        <property type="gene ID" value="CP523_09170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34747">
        <property type="protein sequence ID" value="AYE34747"/>
        <property type="gene ID" value="CP523_10205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35214">
        <property type="protein sequence ID" value="AYE35214"/>
        <property type="gene ID" value="CP523_12715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35479">
        <property type="protein sequence ID" value="AYE35479"/>
        <property type="gene ID" value="CP523_14150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35745">
        <property type="protein sequence ID" value="AYE35745"/>
        <property type="gene ID" value="CP523_15600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59562">
        <property type="protein sequence ID" value="QAS59562"/>
        <property type="gene ID" value="EI377_01345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59980">
        <property type="protein sequence ID" value="QAS59980"/>
        <property type="gene ID" value="EI377_03915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60056">
        <property type="protein sequence ID" value="QAS60056"/>
        <property type="gene ID" value="EI377_04350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60075">
        <property type="protein sequence ID" value="QAS60075"/>
        <property type="gene ID" value="EI377_04480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60076">
        <property type="protein sequence ID" value="QAS60076"/>
        <property type="gene ID" value="EI377_04490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60138">
        <property type="protein sequence ID" value="QAS60138"/>
        <property type="gene ID" value="EI377_04965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60255">
        <property type="protein sequence ID" value="QAS60255"/>
        <property type="gene ID" value="EI377_05630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60335">
        <property type="protein sequence ID" value="QAS60335"/>
        <property type="gene ID" value="EI377_06050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60720">
        <property type="protein sequence ID" value="QAS60720"/>
        <property type="gene ID" value="EI377_08210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60834">
        <property type="protein sequence ID" value="QAS60834"/>
        <property type="gene ID" value="EI377_08875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60865">
        <property type="protein sequence ID" value="QAS60865"/>
        <property type="gene ID" value="EI377_09055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61811">
        <property type="protein sequence ID" value="QAS61811"/>
        <property type="gene ID" value="EI377_14305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00010"/>
    <dbReference type="KEGG" id="csep:CP523_01865"/>
    <dbReference type="KEGG" id="csep:CP523_02990"/>
    <dbReference type="KEGG" id="csep:CP523_03115"/>
    <dbReference type="KEGG" id="csep:CP523_03880"/>
    <dbReference type="KEGG" id="csep:CP523_03965"/>
    <dbReference type="KEGG" id="csep:CP523_06630"/>
    <dbReference type="KEGG" id="csep:CP523_06640"/>
    <dbReference type="KEGG" id="csep:CP523_08965"/>
    <dbReference type="KEGG" id="csep:CP523_09170"/>
    <dbReference type="KEGG" id="csep:CP523_10205"/>
    <dbReference type="KEGG" id="csep:CP523_12715"/>
    <dbReference type="KEGG" id="csep:CP523_14150"/>
    <dbReference type="KEGG" id="csep:CP523_15600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS59562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS59980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS60056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS60075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QAS60076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QAS60138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QAS60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QAS60335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QAS60720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QAS60834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QAS60865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="QAS61811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="63" mass="7223" checksum="9C8CBCDE47A15B0A" modified="2018-12-05" version="1">MKTEEILYICTICGAKENIPKEVVEYFDEMDQSNVDEPPCFSCEKCGGVMRPKEYTGVYGIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI27</accession>
    <name>A0A386PI27_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-cone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_15760</name>
        <name evidence="6" type="ORF">EI377_10475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678919.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00112"/>
    <dbReference type="EnsemblBacteria" id="AYE35775">
        <property type="protein sequence ID" value="AYE35775"/>
        <property type="gene ID" value="CP523_15760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61113">
        <property type="protein sequence ID" value="QAS61113"/>
        <property type="gene ID" value="EI377_10475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="10339" checksum="FD3765980C5234F2" modified="2018-12-05" version="1">MEILKKNGKKEEFSSKKLITSIENAGRDADTILNESDLNMLKKDIIKTLEQIREKTEITSSYEIIGVVIDTLKKEGFRNIIKTYIRYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI40</accession>
    <name>A0A386PI40_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_07265</name>
        <name evidence="16" type="ORF">EI377_02020</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673748.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01070"/>
    <dbReference type="EnsemblBacteria" id="AYE34262">
        <property type="protein sequence ID" value="AYE34262"/>
        <property type="gene ID" value="CP523_07265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59669">
        <property type="protein sequence ID" value="QAS59669"/>
        <property type="gene ID" value="EI377_02020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
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</entry>
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</entry>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
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    <sequence length="126" mass="14663" checksum="31FC47B52EF0BAE7" modified="2018-12-05" version="1">MNDKYTEDDYCDLNRKKICDNCGKCLEEQGMDIKAIKIEDIAKTVEENEYLENELKKALEELKKTSNNEEGIMTAEEFLAENNEESGYVDAFDHIEYLEDGDFFDEVNLDELTEEIFPGVRKLKSK</sequence>
</entry>
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                <person name="Leendertz F.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lighty M.E."/>
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                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AYE35510">
        <property type="protein sequence ID" value="AYE35510"/>
        <property type="gene ID" value="CP523_14310"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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        <location>
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    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
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            <begin position="207"/>
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            <begin position="351"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AYE35510.1"/>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="489" mass="54341" checksum="EEA186E4FAE2B7FA" modified="2018-12-05" version="1">MKIGGNEATNKCFVMATTALAAVNTIGLVSMIKRNTMELKFAVLTMLIILISTSTMFFRYLKDKNNIKIRHIVGTPYAVVYGLTLFATNSIVAPITIVPLIVICMVYLDEKYLVIPIVGASILNLIWSYLKMGNPITDSYILLQLVSIIMFFIMAYVVAKISNKIRKTANEESLKTIELVEEQNKIIEGVKDAIELLNKNTQSISCFFTTIESSSSDIQSAIGEILNGCENSTKSIDKQNRATSNIKKEIEDAVISSKDMENNFNESQTTFIKTFEIVDALSKKSDIIKAKNEKVSKTSNNLKEKAKKVLSIIYIIQSISEKTNLLALNAAIESARAGEFGKGFSVVAEEIRKLAEQSKKSSEEINNILQELEKEVVNVAESILEVTEIIKEEEVLVKDTTINLENLKLDIDEVASKVQSVNEKINSINRDNVKVSEGIMNVASVSEQTLANSQNTSSIVNLLFKEVINSKDSLNELVTLSERLNEYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI84</accession>
    <name>A0A386PI84_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF951 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07575</name>
        <name evidence="2" type="ORF">EI377_02265</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673828.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01124"/>
    <dbReference type="EnsemblBacteria" id="AYE34312">
        <property type="protein sequence ID" value="AYE34312"/>
        <property type="gene ID" value="CP523_07575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59706">
        <property type="protein sequence ID" value="QAS59706"/>
        <property type="gene ID" value="EI377_02265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037263">
        <property type="entry name" value="DUF951_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="6896" checksum="F18ED7AB990671CE" modified="2018-12-05" version="1">MIDTFELGDIIEMKKQHPCGSKAFEVIRLGADIKIKCTGCGRIIMLPRSKFQKDAKKIVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI94</accession>
    <name>A0A386PI94_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 16" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="15" type="ORF">CP523_07630</name>
        <name evidence="16" type="ORF">EI377_02320</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673889.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01135"/>
    <dbReference type="EnsemblBacteria" id="AYE34322">
        <property type="protein sequence ID" value="AYE34322"/>
        <property type="gene ID" value="CP523_07630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59717">
        <property type="protein sequence ID" value="QAS59717"/>
        <property type="gene ID" value="EI377_02320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="13">
        <location>
            <begin position="9"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="14">
        <location>
            <begin position="401"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS59717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="626" mass="70336" checksum="4BDE4556BD016048" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC1</accession>
    <name>A0A386PIC1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_07925</name>
        <name evidence="9" type="ORF">EI377_02685</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675899.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00700"/>
    <dbReference type="EnsemblBacteria" id="AYE34356">
        <property type="protein sequence ID" value="AYE34356"/>
        <property type="gene ID" value="CP523_07925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59761">
        <property type="protein sequence ID" value="QAS59761"/>
        <property type="gene ID" value="EI377_02685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="341" mass="36913" checksum="89A438F02482E237" modified="2018-12-05" version="1">MINISKKTIKISIVLIIIILAIFTISLGFGEVMVSPLEVLKSILGIDSGFSSILVMNIRLPRVIVAFFVGSSLALSGAILQGVVKNHLASPDILGIVNGGAVGALVFLTMFIDPKNNSLTTSILYMPLFTFAFSFIAVILIFLISGKSTSTNKLIIIGIGVSAIFKALTNILIINGPVIFIKEATTWITGSIYGVNWTHAIIIMVTFIFFTILTIIFTKDLNLHQLDDEVIIVLGNNLRKRRLILLSISAALSAGAVTIGGGISFVGLIAPHIARKLVDSKFENITLLSILIGGIITLIADFVSKWLFYPQDLPIGIFTASIGAPYFIYLLIKNRKYSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC4</accession>
    <name>A0A386PIC4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10685</name>
        <name evidence="6" type="ORF">EI377_05470</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01365"/>
    <dbReference type="EnsemblBacteria" id="AYE34831">
        <property type="protein sequence ID" value="AYE34831"/>
        <property type="gene ID" value="CP523_10685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60226">
        <property type="protein sequence ID" value="QAS60226"/>
        <property type="gene ID" value="EI377_05470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="106"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="360"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="450" mass="51375" checksum="2951B74F5DEE66A5" modified="2018-12-05" version="1">MGKRKREVDNPVARKKSLKNEHLRKKKMRIQQKRRKIKRSIMAFIILLLILVIGGGIYIYSFLAGLNNHTTLSKPLTPGWNEPVNILIVGMDIGDTENLENKAGRRTDSIMVLNYNPSTKKVHLVSVPRDTMIEVDAYVDDGQYQRYWKINAAYTLGGEEELIKHIQNLLDVKINYMVEIDYKAFRNLVDAVGGVDMYIDQDMFYDDDVQNLHIRFNAGENVHLDGQKAEEFFRWRKNNDGTGLINGDIDRIKNQQKFISKLVEKCLTPSIIFKVPDILKSISDNVDTNLTANRMLSLGLSILRLKPEDIIMTSLKGEFQEIYRQDYLIVDKKDNIELINSLSSSELSNDSIATSKKKEDIKIMVLNGTKVNGLAGNLQTKLNESGYTSVDVGNSLEPRDKSVIQTNDKEIRNLLKNDTDISKTEKLTNEQYESYDVVIILGNDYNLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE1</accession>
    <name>A0A386PIE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08030</name>
        <name evidence="4" type="ORF">EI377_02790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675935.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00721"/>
    <dbReference type="EnsemblBacteria" id="AYE34376">
        <property type="protein sequence ID" value="AYE34376"/>
        <property type="gene ID" value="CP523_08030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59782">
        <property type="protein sequence ID" value="QAS59782"/>
        <property type="gene ID" value="EI377_02790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="83" mass="9585" checksum="E0869AB3AEE2D3E0" modified="2018-12-05" version="1">MEYKNTLNKIDSSDYVEVVNLDVNGDMRRRFLDLGIINGTKIKILYRSPLGDPRAYLIRGAVIAIRDDEAKHIYVQSLKKEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE8</accession>
    <name>A0A386PIE8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35895">
        <property type="protein sequence ID" value="AYE35895"/>
        <property type="gene ID" value="CP523_15435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="88" mass="10245" checksum="7476E44707D5E456" modified="2018-12-05" version="1">MNKTTTFKEVFSSAKESDKLLYYKLPEKTTAQKIYKLRKLNGLTQKKFAEITGVGFSCISKYELGYKPSNKNLIKIMNKFNLSFNYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ5</accession>
    <name>A0A386PIJ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08345</name>
        <name evidence="2" type="ORF">EI377_03090</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34436">
        <property type="protein sequence ID" value="AYE34436"/>
        <property type="gene ID" value="CP523_08345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59839">
        <property type="protein sequence ID" value="QAS59839"/>
        <property type="gene ID" value="EI377_03090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7515" checksum="42EA49A91F8AB737" modified="2018-12-05" version="1">MKGKIIDYSSTEAFVCLEDDTIIKLPLSEVGNYNLIGSNINVSCQSGSFGYCNNHAGKIYKDNIVDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK1</accession>
    <name>A0A386PIK1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pepA</name>
        <name evidence="10" type="ORF">CP523_08395</name>
        <name evidence="11" type="ORF">EI377_03140</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674788.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01620"/>
    <dbReference type="EnsemblBacteria" id="AYE34446">
        <property type="protein sequence ID" value="AYE34446"/>
        <property type="gene ID" value="CP523_08395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59849">
        <property type="protein sequence ID" value="QAS59849"/>
        <property type="gene ID" value="EI377_03140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="339"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="492" mass="53979" checksum="9E5BF4B90ED1247B" modified="2018-12-05" version="1">MNIGFKNMTCSQVDALVIYLLENKLKTPNEALNKSISLLEERELFLGKQGDVYTFTRDINSNIQTVILIGLGKEENLHLEVLRKAVGKSIKKCRELRLSNIFLRLPDTNKLLPEEMAKAFTYAAKLADYTFDNYKTSKKDKKDINVSIGIHDVESLDKEAIVSSIEEGNDIANAVITARDLVNEPSNIIYPETLAEEAIKIGVNNGFEVEVYDLDKIKELGMEAFYNVAKASVNEPKFIIMRYFGDEENKENILGLVGKGLTYDSGGYSIKPTGSMMDMKSDMGGAAAVIGAMAVIAKRKLKSNVIAVVAACENLISGNGYKPGEIIGSMAGKTIEVVNTDAEGRLTLVDAVHYVIEKENAKEIIDVATLTGAALHALGETTTAVVTNSNDFYKELKDVSEYTGEKVWQLPAFDEYRKLIKSDIADLKNSGGRLAGTITAGLFIEAFVQNKPWLHLDIAGTAWASSVSDYSIKGGTGVPVSTLYELVKRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM8</accession>
    <name>A0A386PIM8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">prmC</name>
        <name evidence="10" type="ORF">CP523_10110</name>
        <name evidence="11" type="ORF">EI377_04910</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676595.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00351"/>
    <dbReference type="EnsemblBacteria" id="AYE34728">
        <property type="protein sequence ID" value="AYE34728"/>
        <property type="gene ID" value="CP523_10110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60129">
        <property type="protein sequence ID" value="QAS60129"/>
        <property type="gene ID" value="EI377_04910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10110"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
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        <location>
            <begin position="406"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="490"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <location>
            <position position="490"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE34728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60129.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="585" mass="66469" checksum="484740D0A1CFB755" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">RNA-binding transcriptional accessory protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="QAS60174"/>
        <property type="gene ID" value="EI377_05160"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
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    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
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            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="723" mass="81448" checksum="B6CC11BA3A8C256D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677501.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35327">
        <property type="protein sequence ID" value="AYE35327"/>
        <property type="gene ID" value="CP523_13320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="513" mass="61879" checksum="6CC3288117035166" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT9</accession>
    <name>A0A386PIT9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05880</name>
        <name evidence="6" type="ORF">EI377_00370</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01879"/>
    <dbReference type="EnsemblBacteria" id="AYE34029">
        <property type="protein sequence ID" value="AYE34029"/>
        <property type="gene ID" value="CP523_05880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59402">
        <property type="protein sequence ID" value="QAS59402"/>
        <property type="gene ID" value="EI377_00370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <sequence length="2835" mass="325104" checksum="BECD6129450C8107" modified="2018-12-05" version="1"> </sequence>
</entry>
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                <person name="Seyboldt C."/>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="599" mass="69521" checksum="246CEBA9B5AE2C15" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    <reference evidence="9" key="2">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QAS60212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="EI377_05400"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RodA/MrdB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="72"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="368"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="375" mass="41504" checksum="D2A55203ECFBB9F6" modified="2018-12-05" version="1">MFSKFTINFKQLKEIDKGILFSMIGLMLFGIVNIYLASRAEYGTLFLKRQSVWFVVCLIALYFMIAIDYTVLKVYTPIFYWGSILLLIVTMFIGTDINGARGWIRLGPLSFQPAELAKIATIMMLGRQLDDMDGTINEWNNFWKMAFYAIVPAVFIVIQPDMGMTMVLFFIVVGIFFIGGLDIRVIGGGLLSLFIVVILVWNSGVIQPYQKKRVTSFLNPEADSSASGYQLRQSLISIGSGGITGSNNSKLKDSSNGYASQYVPEVQTDFIFASIGEQWGFLGASFLLLLYGILISKMIAIGRTAKDKFGSIICVGLVAYFLFAILQNIGMTIGLMPITGITLPLISYGGSSLLTTVLSIGLVVNIGMRRKKIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY0</accession>
    <name>A0A386PIY0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GGGtGRT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13645</name>
        <name evidence="2" type="ORF">EI377_08535</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677189.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35387">
        <property type="protein sequence ID" value="AYE35387"/>
        <property type="gene ID" value="CP523_13645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60776">
        <property type="protein sequence ID" value="QAS60776"/>
        <property type="gene ID" value="EI377_08535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025964">
        <property type="entry name" value="GGGtGRT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14057">
        <property type="entry name" value="GGGtGRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="333" mass="35549" checksum="513AED19F8C79B8C" modified="2018-12-05" version="1">MALFESYERRINQITPVLKKYGMEKIEDAKAVCDEKGINVYDIVKSTQPIAFENAMWAYTLGAAIAIKKGCVKAADAAEALGEGLQAFCIPGSVADDRKVGLGHGNLGAMLLREETKCFAFLAGHESFAAAEGAIKIAEKANKVRKEPLRVILNGLGKDAAYIISRINGFTYVQTKFDYMTGKLEIVKEKAYSNGPRAAVKCYGSDDVREGVAIMHHEGVDVSITGNSTNPTRFQHPVAGTYKKECVEQGKKYFSVASGGGTGRTLHPDNMAAGPASYGMTDTMGRMHSDAQFAGSSSVPAHVEMMGLIGMGNNPMVGATVAVSVAIEEAMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ23</accession>
    <name>A0A386PJ23_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetaldehyde dehydrogenase (Acetylating)</fullName>
            <ecNumber evidence="4">1.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12480</name>
        <name evidence="4" type="ORF">EI377_07365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675317.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02017"/>
    <dbReference type="EnsemblBacteria" id="AYE35171">
        <property type="protein sequence ID" value="AYE35171"/>
        <property type="gene ID" value="CP523_12480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60574">
        <property type="protein sequence ID" value="QAS60574"/>
        <property type="gene ID" value="EI377_07365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013357">
        <property type="entry name" value="Acetaldehyde_DH_acetylating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02518">
        <property type="entry name" value="EutH_ACDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="530" mass="56859" checksum="419DCF46E296243D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ81</accession>
    <name>A0A386PJ81_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_12860</name>
        <name evidence="11" type="ORF">EI377_07730</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678242.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03039"/>
    <dbReference type="EnsemblBacteria" id="AYE35241">
        <property type="protein sequence ID" value="AYE35241"/>
        <property type="gene ID" value="CP523_12860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60635">
        <property type="protein sequence ID" value="QAS60635"/>
        <property type="gene ID" value="EI377_07730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="49"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="377"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="410"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="619" mass="68710" checksum="95CEC5BD4BF6D7DF" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ99</accession>
    <name>A0A386PJ99_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine-phosphate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.81</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-threonine-O-3-phosphate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_12965</name>
        <name evidence="12" type="ORF">EI377_07845</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:11492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58563"/>
            <dbReference type="ChEBI" id="CHEBI:58675"/>
            <dbReference type="EC" id="4.1.1.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678208.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03019"/>
    <dbReference type="EnsemblBacteria" id="AYE35261">
        <property type="protein sequence ID" value="AYE35261"/>
        <property type="gene ID" value="CP523_12965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60656">
        <property type="protein sequence ID" value="QAS60656"/>
        <property type="gene ID" value="EI377_07845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12965"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005860">
        <property type="entry name" value="CobD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01140">
        <property type="entry name" value="L_thr_O3P_dcar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="10">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="356" mass="40710" checksum="3480189115AEC713" modified="2018-12-05" version="1">MTKSIHGGNTAEISRKYGMHEDEIIDFSANINPLGLNKEVKKAMINAIDKVSKYPDITYYNLKKSISNYECINEENLILGNGAAEVIFNVVRGLNPKRVLIPAPTFGEYEEAVLSIDGEIEYYYLSEENKFNLDGGLIDKIDETIDMVFICNPNNPTGVVTSNKYIEEIAKKALKTKTIVVLDESFLDFVDNSEEFTGKYILNKYNNIIIIKSLTKFFAMPGIRIGYGISNNKSVIEKINKVTVAWSINSVAVDGVIEALMQKEYIEDTKKYLNLQKEYLYNELKSFKDLKVFKPSVNFIMFKVLKNIDFKDYLIKRGILIRSCNNYKGLDNNYYRVAVRTKEENNILIQAIKTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJC0</accession>
    <name>A0A386PJC0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07300</name>
        <name evidence="3" type="ORF">EI377_02050</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673757.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01077"/>
    <dbReference type="EnsemblBacteria" id="AYE34269">
        <property type="protein sequence ID" value="AYE34269"/>
        <property type="gene ID" value="CP523_07300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59675">
        <property type="protein sequence ID" value="QAS59675"/>
        <property type="gene ID" value="EI377_02050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362988" evidence="1">
        <location>
            <begin position="27"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="629" mass="70344" checksum="54CFA834ECB75AE6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJC6</accession>
    <name>A0A386PJC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11650</name>
        <name evidence="3" type="ORF">EI377_06470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673375.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02889"/>
    <dbReference type="EnsemblBacteria" id="AYE35018">
        <property type="protein sequence ID" value="AYE35018"/>
        <property type="gene ID" value="CP523_11650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60412">
        <property type="protein sequence ID" value="QAS60412"/>
        <property type="gene ID" value="EI377_06470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE35018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="433" mass="50731" checksum="A2C1925088321189" modified="2018-12-05" version="1">MEILALGEKIKRRRKELNMTLKDLAGDRITPGQISLVESGRSNPSMDLLEYLADELNTSVEYLMESEESQAEKISIYYEQVAESYILAGEHITAEKYIENALYYSERYDLEYRKAKILYLRARIYMSKGELVLAQQFFLSSNVIFIKNNNYEEIINTFLNLGRITLQLKAYHSASSYLRQAEKVYIDNNIGNDYLLGEIYYFMAQAYFKTDNVGKAMDYSFLAKSKFDQVNNRNEYAKTLLLLSEEYNKKGDLGNAIKYSQKTLEVYRELEELTNVSEIENNLGKLFYEFENIEESFKHYEVAKEIRIKKKDDKLVETLINICENYIKIKNIPKCEEVLKEINGYLKEDDLEGLVEYNLLWYRIYIMKEMPKEAEYILLDSYNLAKANNLNKKAGEIAIMIGKFYIDNKKDFEAAKYLDEGVNVFRKIGILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJH5</accession>
    <name>A0A386PJH5_CLOSE</name>
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        <submittedName>
            <fullName evidence="4">Transcription repressor NadR</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">CP523_07800</name>
        <name evidence="5" type="ORF">EI377_02490</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02107"/>
    <dbReference type="EnsemblBacteria" id="AYE34339">
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        <property type="gene ID" value="CP523_07800"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59735"/>
        <property type="gene ID" value="EI377_02490"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3H_dom_sf"/>
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        <property type="entry name" value="3H_domain"/>
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        <property type="entry name" value="HTH_11"/>
    </dbReference>
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        <property type="entry name" value="NadR"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR40068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02829">
        <property type="entry name" value="3H"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08279">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037847">
        <property type="entry name" value="NiaR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
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    </dbReference>
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        <property type="entry name" value="SSF75500"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="3">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="3H" evidence="2">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037847-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="168" mass="18935" checksum="665152EFF88BC6CF" modified="2018-12-05" version="1">MASTKRREDIIRLLMTSNLPIKGTDLAKKFGVTRQIIVKDIAILRASGNSIIATPDGYIYNAINNKIKSIIAVNHNINETISELETVVKYGGTIEDVIIEHSLYGEIRGNLMIKNLYDLNKFQDEFNNKNVKPLSNLTNGIHLHTISADREEDIESIKLELKQKGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI0</accession>
    <name>A0A386PJI0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_10330</name>
        <name evidence="9" type="ORF">EI377_05110</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01429"/>
    <dbReference type="EnsemblBacteria" id="AYE34766">
        <property type="protein sequence ID" value="AYE34766"/>
        <property type="gene ID" value="CP523_10330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60165">
        <property type="protein sequence ID" value="QAS60165"/>
        <property type="gene ID" value="EI377_05110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="329" mass="35131" checksum="9EB1AF4DB3DF5D5E" modified="2018-12-05" version="1">MKKNNIIKKNIYIGISVVVLIILSLSSMKIGSIDITLKELLVGIFTNNGGETWDIIRDLRMPRVITAILVGSSLAVSGVLLQAVIRNPLAEPSITGISSGASLFSVVVMVFLPSLTSYRYLFGFLGGILACIVVYSLAFKNTLSPIRIVLTGIAVNAMLGGIISITTIFNGNNASSVQMWLTGSLVAVTWKDVFPLLAYTIIGLICAFILSRTCNVIVLGDKNSKGLGFNADKTRIIISLVAVFLAGVSTSVAGIISFVGLVVPHICRIIIGSNHRYLIPFSCTLGAILLLIADTLGRTIAKPYEIPVGIVMAILGAPFFLYLLRKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ6</accession>
    <name>A0A386PJJ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10690</name>
        <name evidence="6" type="ORF">EI377_05475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674137.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01364"/>
    <dbReference type="EnsemblBacteria" id="AYE34832">
        <property type="protein sequence ID" value="AYE34832"/>
        <property type="gene ID" value="CP523_10690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60227">
        <property type="protein sequence ID" value="QAS60227"/>
        <property type="gene ID" value="EI377_05475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="87"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="33818" checksum="E05ECE79B002F45A" modified="2018-12-05" version="1">MSTIKKTVIKDFEGRKIREYLKEELGLSSRLIKGAAIDKRIFVNNKAVKMNYVLKENEEVLINLCKEESQNITPEPMDLDIVYEDEDIIVINKRPNMVVHPTKRYQSGTLANGLLYYFKETNQKCIVRLVSRLDMDTSGLIIVAKNQYAHMELSKDMSQNNIEKRYLSVVHGNLENMEGTIDLPIYRPEGEGVIGRVIDERGQRSITHYKVVKRLADRDVVECLLETGRTHQIRVHLKALGHPIYGDTLYGYEEDSEIIGRQALHAYGLDFKSPRTKKSLSLRAELPEDIKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR3</accession>
    <name>A0A386PJR3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08360</name>
        <name evidence="3" type="ORF">EI377_03105</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674775.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01613"/>
    <dbReference type="EnsemblBacteria" id="AYE34439">
        <property type="protein sequence ID" value="AYE34439"/>
        <property type="gene ID" value="CP523_08360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59842">
        <property type="protein sequence ID" value="QAS59842"/>
        <property type="gene ID" value="EI377_03105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="30823" checksum="26C37AABAFFCCFBE" modified="2018-12-05" version="1">MQKIAILTDSACDLSLETMKEKNIKLLPLKLIYSDKEFQDKIDISAEEVYNNLKNEVPKTSLPSAETIHNILDGLENDGYTHVIAITISSGLSGTFNAIRLALEDHPKLTSHVYDSKILAFPEGLLVLETAKLIEEGKSFEEITEVLPKIHSNITGYFTIDTLEYLKKGGRIGRVAGTIGEILNLKPIITVDENGVYYTVCKARGHKQALTKLTDILKKELEKSKCNVWVLQGGALKTAKSYLETLLKLDNILNVGISEISPALGVHAGPGLIGLAIQKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJY0</accession>
    <name>A0A386PJY0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="9">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">proS</name>
        <name evidence="11" type="ORF">CP523_08855</name>
        <name evidence="12" type="ORF">EI377_03610</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02711"/>
    <dbReference type="EnsemblBacteria" id="AYE34519">
        <property type="protein sequence ID" value="AYE34519"/>
        <property type="gene ID" value="CP523_08855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59921">
        <property type="protein sequence ID" value="QAS59921"/>
        <property type="gene ID" value="EI377_03610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="38"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="570" mass="64019" checksum="D0D14C16865AC3B8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK30</accession>
    <name>A0A386PK30_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02904"/>
    <dbReference type="EnsemblBacteria" id="AYE35032">
        <property type="protein sequence ID" value="AYE35032"/>
        <property type="gene ID" value="CP523_11725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="1">
        <location>
            <begin position="204"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="345" mass="40925" checksum="FC36929FCD9961AE" modified="2018-12-05" version="1">MYSIFSFFKRFKIKKNILIQDKSLVEIEKVLMGYFSHCIENEKKLKQKSNKYIYPKSILENYNKVYYSFIIEMYKNIKVKAEFYNIFLNINSINIIEKSIVVDVDKIIEIKYKNSKVKTKYKDNHLIYLNIKNNKLFVSRDIIEEGIKADELVNTISSYEKYMENKINIIKKNKSSLKEYINNFNKRSNPKVQENKKGVYRYSGYDGNLAAKWASENWDAEEEYQGNDCTNFVSKCLKNGGLPMDKIWRPGSYAWIRVVNLRNWLVNTGYGVENKDNSNLSLGDVVQLHSRSKDMWSHSTIITYIDEQGEIYVSAHSYPYYNRPLFSYYPTYAYSNIRYLRIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK32</accession>
    <name>A0A386PK32_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13380</name>
        <name evidence="3" type="ORF">EI377_08270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677525.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00771"/>
    <dbReference type="EnsemblBacteria" id="AYE35338">
        <property type="protein sequence ID" value="AYE35338"/>
        <property type="gene ID" value="CP523_13380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60729">
        <property type="protein sequence ID" value="QAS60729"/>
        <property type="gene ID" value="EI377_08270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="58"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="273" mass="31625" checksum="6046E50EC3E4D62E" modified="2018-12-05" version="1">MNFKLEEKLSMLPLMWRITRYNLFSDKNVRFRDVKYGKNKRQYYRVFEGNDNEKPLIYFIHGGGWWHGSPKMCTCIGKYFNKLGYTVVLPSYRLVPIYKYPTQIEDVFTAFSHYIEDKNFKRGIIIMGFSAGGELAANLLFNKKIHEKYNIDNKIFKKMVSISGVLDFNKCTSRHAKTLIENYLGKNESFNGKNPVDLISYKSHISVLCIHGDRDPLINTDNSFSFVDKINKLQGYGKVILIKGKHHSDMTGLLLGKGEKDSNVVLEFIKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK99</accession>
    <name>A0A386PK99_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15445</name>
        <name evidence="3" type="ORF">EI377_10160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679277.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000076.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01941"/>
    <dbReference type="EnsemblBacteria" id="AYE35714">
        <property type="protein sequence ID" value="AYE35714"/>
        <property type="gene ID" value="CP523_15445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61056">
        <property type="protein sequence ID" value="QAS61056"/>
        <property type="gene ID" value="EI377_10160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="10184" checksum="C6612E7FF6C06B2A" modified="2018-12-05" version="1">MLKIERMISPYNHYEGNSIKYIVVHGTGTPEGTDSARNNAIYFYGANRNASAHYFVDATSIYQSVEDDNLTEFIMNNRCGIINKRKIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKD3</accession>
    <name>A0A386PKD3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12535</name>
        <name evidence="3" type="ORF">EI377_07425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675286.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35182">
        <property type="protein sequence ID" value="AYE35182"/>
        <property type="gene ID" value="CP523_12535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60585">
        <property type="protein sequence ID" value="QAS60585"/>
        <property type="gene ID" value="EI377_07425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="128" mass="14734" checksum="A188989900CB9C7D" modified="2018-12-05" version="1">MNINKIFILNVNHLLIGNFKISNTIDVVATIFLLSIVISYGYFYFSSTQILYKDGIKLMYNKFITKDGIEDIFYRDTFIRKGKVFEINTKDGSLGFRKKVNIGCKSEEEFLKTLISLEELTGLPIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKD9</accession>
    <name>A0A386PKD9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CotS family spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10010</name>
        <name evidence="3" type="ORF">EI377_04795</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676559.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00331"/>
    <dbReference type="EnsemblBacteria" id="AYE34709">
        <property type="protein sequence ID" value="AYE34709"/>
        <property type="gene ID" value="CP523_10010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60110">
        <property type="protein sequence ID" value="QAS60110"/>
        <property type="gene ID" value="EI377_04795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="331" mass="39633" checksum="67C2EF7DE07D021E" modified="2018-12-05" version="1">MNFLDIKNAVENNYSLNVIDIEKVKNTYKIKTEEGDYGVKVIKYKYPHFYFIFSAIRHLQHRNFLKIPEIINTKDGLGFVKIQNNYAYLNEWIPSRKSNYDNLQELEKIAEKLGELHKCSEGFTLSNEMKPRIGWYSWIHVFETRCEEILDFKKRISQKAYKSEFDSLFLEAIDEEVNRGARAILNLKEGKYIEIMDREVCKRGFCHHDFANHNVLIDEENDVNIIDFDYCILDSHLHDLSSLLIRAMKGGKWSVEKASLILNSYSKTHDLYEEELKLMKGFIEFPQGFWQIGLQYYWEQQPWGEEFMVNKISKYLNDREERERFIEEFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE0</accession>
    <name>A0A386PKE0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MogA/MoaB family molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_15650</name>
        <name evidence="6" type="ORF">EI377_10365</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678618.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00561"/>
    <dbReference type="EnsemblBacteria" id="AYE35754">
        <property type="protein sequence ID" value="AYE35754"/>
        <property type="gene ID" value="CP523_15650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61092">
        <property type="protein sequence ID" value="QAS61092"/>
        <property type="gene ID" value="EI377_10365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15650"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="163" mass="18084" checksum="1BC4D79F2060C95A" modified="2018-12-05" version="1">MYTIGIITSSDKGYKGEREDRSGEVIKEIVEANGFEVKKYIILPDEKDMLSNELLYMSDELNLNLILTTGGTGFSTRDVTPEATKVVIERETPGICEAIRWYSLSITKRAMLSRAVSGIRKNTLIVNLPGSPKACKEALEFALDDIKHGIDILLGEAKECARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI2</accession>
    <name>A0A386PKI2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14040</name>
        <name evidence="8" type="ORF">EI377_08945</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00225"/>
    <dbReference type="EnsemblBacteria" id="AYE35458">
        <property type="protein sequence ID" value="AYE35458"/>
        <property type="gene ID" value="CP523_14040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60846">
        <property type="protein sequence ID" value="QAS60846"/>
        <property type="gene ID" value="EI377_08945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="6">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="347" mass="37347" checksum="E517F6C74DA268A6" modified="2018-12-05" version="1">MGNVSVVGAEELKSGAKVIVSGNTFFSDFEIDGKNSESHSNINVTKNVLDWMLPKKEAKTVKIAEVRKDDNNDGIPDLQGEEFTVEGTVTSQSEAVTPKNAFFEVVYIEDETGGLCVFGVSNTELKVGQKVRVTGQVEHYQGEFEISIKDEDNQLEIIDENISEIKPTKLTTKESMLSINGGKLVEVEGKVVKMDGSNLYVDDGSGISRSYVEGYIWDGMNEESKGKWDPEIKVGDTISVIGLVSIDPEGERLRVRNTSEIKLLKNEEIPGGGEDSGGDQEGDSGSDNGSGNGNNSGNDSNLGSTDKNKTEGKLPQTGGVNSTVVMVLSIIVLVGGVILVFKKKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKQ3</accession>
    <name>A0A386PKQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13455</name>
        <name evidence="3" type="ORF">EI377_08355</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00788"/>
    <dbReference type="EnsemblBacteria" id="AYE35352">
        <property type="protein sequence ID" value="AYE35352"/>
        <property type="gene ID" value="CP523_13455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60743">
        <property type="protein sequence ID" value="QAS60743"/>
        <property type="gene ID" value="EI377_08355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="673" mass="77622" checksum="17D4D988EE82B9FD" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKQ6</accession>
    <name>A0A386PKQ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_32N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12890</name>
        <name evidence="4" type="ORF">EI377_07770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03034"/>
    <dbReference type="EnsemblBacteria" id="AYE35246">
        <property type="protein sequence ID" value="AYE35246"/>
        <property type="gene ID" value="CP523_12890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60641">
        <property type="protein sequence ID" value="QAS60641"/>
        <property type="gene ID" value="EI377_07770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="84" mass="9942" checksum="BB718153D6718517" modified="2018-12-05" version="1">MLQRAYLWGYFIVLGARTKDDKSALLIYRSDNLYNWKLYKEIVAKDRKFGYMWGCPDLFKLNGENVMIFSPQGLGVIDIIKWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKY9</accession>
    <name>A0A386PKY9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-amino-4-deoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_13530</name>
        <name evidence="7" type="ORF">EI377_08430</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00802"/>
    <dbReference type="EnsemblBacteria" id="AYE35366">
        <property type="protein sequence ID" value="AYE35366"/>
        <property type="gene ID" value="CP523_13530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60757">
        <property type="protein sequence ID" value="QAS60757"/>
        <property type="gene ID" value="EI377_08430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="29153" checksum="FDCDD631916F6A11" modified="2018-12-05" version="1">MRNIIYNDEKIILDEGIFFGRGVFETILIKEKPIFLKEHICRLNRGIELLELGDKIKEDFLDKEIEKLHLRNKVLKVLVSPKNIILTERDIPYSKEDYKNGFKLKISKVIRNSTSPLVYIKSISYMDNLLENKKAKKEGYNEVIFLNEKGYLTEGSTSNIFLVKDNKLYTPKIESGLLNGIIREYILKNTNCEEVKLTLNDLINSDEVFITNSLLGIMKVISIEDKIFREHKFTDSINRKYLVDIEKLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL67</accession>
    <name>A0A386PL67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CoA transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14775</name>
        <name evidence="2" type="ORF">EI377_09735</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676123.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01329"/>
    <dbReference type="EnsemblBacteria" id="AYE35592">
        <property type="protein sequence ID" value="AYE35592"/>
        <property type="gene ID" value="CP523_14775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60978">
        <property type="protein sequence ID" value="QAS60978"/>
        <property type="gene ID" value="EI377_09735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="396" mass="43848" checksum="0382458C5D268111" modified="2018-12-05" version="1">MSKALKGIKVLDLTHAYNGPFCTTLLADNGADVIKIEPPQGDQCRTWGPIDEKSGESGFYAFLNRNKKGITLNLKTKEGKEIFYKMVREADVVVENFRGGVSKKLGVDYETLKKINPNIVYASGSGFGQYGPLANRPCYDIVAQSMAGMVNLTGFPDSPPTKVGPSIADNVTGIYLCVGVLLALYNREKTGMGQSVDVAMLDTIFTLLENSIVTNTMTNVIPQRQGNIDPSIAPFDIYMARDGYIAIGVGNDKLWSKFCKVMNRIDLLEDEKYATNDLRCKNYLPDLQNIIRDWAKDRNKKDIENICAEAGIPCGPVLDMKEAIEHPQIQAREMMVHMEHPLIGDMYFQGVPIKLSRTPGGVDTPAPTLGQHNSEVYKNFGIDENKLEKLRKQGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLD3</accession>
    <name>A0A386PLD3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12690</name>
        <name evidence="10" type="ORF">EI377_07590</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675194.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01971"/>
    <dbReference type="EnsemblBacteria" id="AYE35209">
        <property type="protein sequence ID" value="AYE35209"/>
        <property type="gene ID" value="CP523_12690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60611">
        <property type="protein sequence ID" value="QAS60611"/>
        <property type="gene ID" value="EI377_07590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="568"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="929" mass="108075" checksum="23B8390591F49DB1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLH8</accession>
    <name>A0A386PLH8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system F family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_14960</name>
        <name evidence="10" type="ORF">EI377_09915</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676058.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01292"/>
    <dbReference type="EnsemblBacteria" id="AYE35626">
        <property type="protein sequence ID" value="AYE35626"/>
        <property type="gene ID" value="CP523_14960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61013">
        <property type="protein sequence ID" value="QAS61013"/>
        <property type="gene ID" value="EI377_09915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="219"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="351" mass="39768" checksum="02CD799AC1D0BDDE" modified="2018-12-05" version="1">MKANIEGILNRKSDIALSIIAENIYKLYDDGIDILLIMDLLLEVPLPKRYIESIKDIKNLITNGESLGNSLKHHKNIYPEFFISMVEVGEKSGKLSNVLKCLEAYYKKIGLIKKTIINALSYPFIVIISMLVLAIFLVLFVIPSFYDIYLSSGMEVPTSCLVMYKFAEFFKDNRLIASLYIISWGMVLPIILFRILYKNYIENFLNKIHIVNTFNEYIFISLLSIITSSGINLSKGLDYCARSFKGKNVKNSFVIINDKILEGKSLGESLEDINGYSKYTVSMIKLGEISGGMDERLRSLSSYLENKVNSNIKKWMTLIQPIAILLMAGLVLIFIIIFIIPLFDALLGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLJ7</accession>
    <name>A0A386PLJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676000.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35656">
        <property type="protein sequence ID" value="AYE35656"/>
        <property type="gene ID" value="CP523_15115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017349521" evidence="1">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="134" mass="14624" checksum="20A0BA4DF1B82729" modified="2018-12-05" version="1">MKLGGYGNYKKNKFKLIGAVASTFILLSNASPTFASSYEYDFIEGYQILGTTTRGKSGSDYYGGARTTVSTNSILTKTSVGAQFGDGYKSNYSDYYYGSSYIQVTSRRGLPSSVKGTHWAKGFNKTVNFISNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLP7</accession>
    <name>A0A386PLP7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_13755</name>
        <name evidence="9" type="ORF">EI377_08645</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02071"/>
    <dbReference type="EnsemblBacteria" id="AYE35409">
        <property type="protein sequence ID" value="AYE35409"/>
        <property type="gene ID" value="CP523_13755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60797">
        <property type="protein sequence ID" value="QAS60797"/>
        <property type="gene ID" value="EI377_08645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="422"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="644" mass="75564" checksum="BBA7E289FA74E6FD" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLZ4</accession>
    <name>A0A386PLZ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydropyrimidinase</fullName>
            <ecNumber evidence="8">3.5.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hydA</name>
        <name evidence="7" type="ORF">CP523_14760</name>
        <name evidence="8" type="ORF">EI377_09720</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="4">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676129.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01332"/>
    <dbReference type="EnsemblBacteria" id="AYE35589">
        <property type="protein sequence ID" value="AYE35589"/>
        <property type="gene ID" value="CP523_14760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60975">
        <property type="protein sequence ID" value="QAS60975"/>
        <property type="gene ID" value="EI377_09720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease_alpha" evidence="5">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="52"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="461" mass="51425" checksum="F82E9FA4D9FB1B35" modified="2018-12-05" version="1">MSLFDSVIKNGTIVNASDVYRGDIGIKDGKILAISKELEYNAQNIIDATGKYVFPGGIDPHTHMEMPFGGTFSSDDFITGTKAAACGGTTTIIDFAVQPTGKTLNETAKIWRDKADNRTCIDYGIHIVITDMNGNIMNEIPDVINKGYSSFKVFMTYEGMRIDDEILMKTLLKVSENGGLTCVHAENYYVIKYLTEKLLSEGKTEPLYHALSRPDLCEAEAVSRSIKMAELCKTPLYIVHNSCKKSVIEIKRAREEGYHVIGETCPQYLLLSTDNYKEPNFNGAKYVMSPPLRDKENWKYMWEALKKDNLQVIATDHCPFFMNQKKLGINNFTKIPNGAPGVELRMALIYTYGVLENNMSLSRFVEVTSTNAAKIFGLYPQKGSIVVGSDADLVVFDPNKETVVTKSMLNENVDYTPYEGFKLKGYPELTLLRGEIIAKDGKYLGKEGSGRFIKRGAPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM29</accession>
    <name>A0A386PM29_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="11">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="11">DXP synthase</shortName>
            <shortName evidence="11">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">dxs</name>
        <name evidence="13" type="ORF">CP523_15080</name>
        <name evidence="14" type="ORF">EI377_10035</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="11">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676014.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01268"/>
    <dbReference type="EnsemblBacteria" id="AYE35649">
        <property type="protein sequence ID" value="AYE35649"/>
        <property type="gene ID" value="CP523_15080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61036">
        <property type="protein sequence ID" value="QAS61036"/>
        <property type="gene ID" value="EI377_10035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15080"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="12">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="11">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="11">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="617" mass="68546" checksum="D49013847DE19FFF" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMD7</accession>
    <name>A0A386PMD7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_10745</name>
        <name evidence="7" type="ORF">EI377_05530</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01353"/>
    <dbReference type="EnsemblBacteria" id="AYE35859">
        <property type="protein sequence ID" value="AYE35859"/>
        <property type="gene ID" value="CP523_10745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62166">
        <property type="protein sequence ID" value="QAS62166"/>
        <property type="gene ID" value="EI377_05530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="35969" checksum="956B1FBBC08BE301" modified="2018-12-05" version="1">MFKKPTKFVKAVNDIDLTIYRGETLGLVGESGCGKTTLGKSILQLVKPTGGEMIYDFKGDVGKKDLRKLGAKEMDLARKKMQIVFQDPHSSLNPAFTIYQSLSDPLKKFGVKDKNDRRMLIGDILEAVNMRREYMDRYPHEFSGGQRQRIGIARALCINPELVICDESVSALDVSIQAQVLNLLKKIKDERNLTYIFITHDLSVVEYISDRIAVMYLGRIVELAETSQIFSNNLHPYTQALLSAIPIADLDKKKKRIILEGDVPSPVNPPEGCNFHPRCKKCMDICKKERPLLKKYIIDGEEHFVACHLAEEQLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB20</accession>
    <name>A0A386PB20_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00915</name>
        <name evidence="8" type="ORF">EI377_11410</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674550.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02336"/>
    <dbReference type="EnsemblBacteria" id="AYE33115">
        <property type="protein sequence ID" value="AYE33115"/>
        <property type="gene ID" value="CP523_00915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61285">
        <property type="protein sequence ID" value="QAS61285"/>
        <property type="gene ID" value="EI377_11410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="23179" checksum="7470A6BB30F5458F" modified="2018-12-05" version="1">MKAVIVSGGKAPSEKILKNAIKNASIIIGADKGCEVLLKNNITPSYILGDFDSASKETILKFENLGVPKTKFKEEKDFTDTTSAFNLAIDKGCTEILLLGATGTRYDHVLGNIGLLLKAIKLDIKAEIIDDNNRIYLINKNCTLYGNYGDTISFQAYSKKVIGLTIKGSKYNLYNYDLEIGDSLTVSNEFLDSPIEISFKNGPLMVLYTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB23</accession>
    <name>A0A386PB23_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">L-threonine dehydratase catabolic TdcB</fullName>
            <ecNumber evidence="7 13">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_00040</name>
        <name evidence="16" type="ORF">EI377_10520</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid degradation; L-threonine degradation via propanoate pathway; propanoate from L-threonine: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 13">In the native structure, TdcB is in a dimeric form, whereas in the TdcB-AMP complex, it exists in a tetrameric form (dimer of dimers).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="7 13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678960.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00306"/>
    <dbReference type="EnsemblBacteria" id="AYE32950">
        <property type="protein sequence ID" value="AYE32950"/>
        <property type="gene ID" value="CP523_00040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61122">
        <property type="protein sequence ID" value="QAS61122"/>
        <property type="gene ID" value="EI377_10520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00040"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00052">
        <property type="reaction ID" value="UER00507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070689">
        <property type="term" value="P:L-threonine catabolic process to propionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="15"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="43623" checksum="175B88C661484F18" modified="2018-12-05" version="1">MHLEKIQLARETIKDVVIKTPLLYSSFFSNISGNDIYMKCENLQVTGAYKIRGAMNKIRSLSDIEKSKGVVCSSAGNHAQGVAYGASLCNVKSTIVMPKTTPFLKVKSTKEFGGNVVLYGNCYDDAFNEAKRIEEEKHATFLHPFNDFTVIYGQGTIALEIFEDLSNVDVIVCPIGGGGLISGIALAAKKINPNIKIIGVQAKGANAMEKSFKTNKLVKLDSISTIADGIAVKNPGTITFSIIQNYVDDIVTVTDNEIVEAFLILSEKHKLLVEASGAVSLAALKKLNFKNKKIVSIISGGNIDILTISSLINNGLVERGRLFCFAVELPDIPGQLLEISRLLSETGANVVKLEHNQFKANNRLRNVLLEVTVETNGFDHINLVKDTFKNYGYNIIQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB55</accession>
    <name>A0A386PB55_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 5-hydroxyuridine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ho5U methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trmR</name>
        <name evidence="5" type="ORF">CP523_01120</name>
        <name evidence="6" type="ORF">EI377_11620</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60524"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="Rhea" id="RHEA-COMP:15591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
            <dbReference type="ChEBI" id="CHEBI:143860"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02294"/>
    <dbReference type="EnsemblBacteria" id="AYE33153">
        <property type="protein sequence ID" value="AYE33153"/>
        <property type="gene ID" value="CP523_01120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61323">
        <property type="protein sequence ID" value="QAS61323"/>
        <property type="gene ID" value="EI377_11620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02217">
        <property type="entry name" value="TrmR_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043675">
        <property type="entry name" value="TrmR_methyltr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="24473" checksum="FF994AD024E2F5EB" modified="2018-12-05" version="1">MSGITYDYMEEYIRGLIPENTGKYKEMECFAKENGVPIAQKETAKFLEFMVSMKKPLRILELGTAIGYSATLMYEAAGTNPSITTIERDENMIKYAKENFKKFNLEDKIEIKCGDCLEILDKLEEPYDLIFMDAGKGHYNHFLPNCLRLLKKDGVIVADNVLFRGMVASKDLVKRRKITIVKRMKTYLDLVSKDEDLITSVIPMGDGIAVTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB58</accession>
    <name>A0A386PB58_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="3">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">typA</name>
        <name evidence="3" type="synonym">bipA</name>
        <name evidence="5" type="ORF">CP523_01130</name>
        <name evidence="6" type="ORF">EI377_11630</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674427.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02292"/>
    <dbReference type="EnsemblBacteria" id="AYE33155">
        <property type="protein sequence ID" value="AYE33155"/>
        <property type="gene ID" value="CP523_01130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61325">
        <property type="protein sequence ID" value="QAS61325"/>
        <property type="gene ID" value="EI377_11630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="608" mass="68089" checksum="7E38D51C07025FC8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBF7</accession>
    <name>A0A386PBF7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_01695</name>
        <name evidence="5" type="ORF">EI377_12215</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33263">
        <property type="protein sequence ID" value="AYE33263"/>
        <property type="gene ID" value="CP523_01695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61434">
        <property type="protein sequence ID" value="QAS61434"/>
        <property type="gene ID" value="EI377_12215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="150"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="354" mass="40935" checksum="2BB604C536414D05" modified="2018-12-05" version="1">MNNVERKAYNGRYKNQRKKCKVKNSNINKLKKKRYRRRVRNKIIFKFIMISLFVTILIVIKNNISNYKAEKSKENAKNEIVTTIVDDKSNDNKDTEPKKQERYEKQEEIKKSDPHEIMPNSNVTYEGVTYAMDASDVKAMLYGTYAGSKKYVFLTFDDGPSPNTEKVLDILKENNVKGTFFVLGSMIEASTEAQKTLKRIIKEGNALANHTYTHNLSTLYPRNTIDINYFMEEVNNTNKLMKKILGENFNTKVLRMPGGYMSRKYYNDPSLPAFDDKLNSEGIVSIDWNTLNGDAEGVEYTVEEMVNKVKEGAKEVNQSIVLMHDTYGKEKTVEALPEIINYFKSQGYEFRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBV9</accession>
    <name>A0A386PBV9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ORF">CP523_00465</name>
        <name evidence="11" type="ORF">EI377_10955</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676302.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00622"/>
    <dbReference type="EnsemblBacteria" id="AYE33027">
        <property type="protein sequence ID" value="AYE33027"/>
        <property type="gene ID" value="CP523_00465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61196">
        <property type="protein sequence ID" value="QAS61196"/>
        <property type="gene ID" value="EI377_10955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="699" mass="72982" checksum="AB0DB505D3F2C44E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBW6</accession>
    <name>A0A386PBW6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">fliE</name>
        <name evidence="4" type="ORF">CP523_02620</name>
        <name evidence="5" type="ORF">EI377_13155</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673906.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00443"/>
    <dbReference type="EnsemblBacteria" id="AYE33433">
        <property type="protein sequence ID" value="AYE33433"/>
        <property type="gene ID" value="CP523_02620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61607">
        <property type="protein sequence ID" value="QAS61607"/>
        <property type="gene ID" value="EI377_13155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="96" mass="10917" checksum="D529D80FBE9B0034" modified="2018-12-05" version="1">MRVNSFIPANSNLEINSAKDGEEKVNSFKSFLKEGLDKLNEKQVISDKLTEEFESGDIDVHKMMLATEEAKMSLQLAVQVRNKFVEAIQELTRTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBX4</accession>
    <name>A0A386PBX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WYL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01680</name>
        <name evidence="4" type="ORF">EI377_12200</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675702.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00888"/>
    <dbReference type="EnsemblBacteria" id="AYE33260">
        <property type="protein sequence ID" value="AYE33260"/>
        <property type="gene ID" value="CP523_01680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61431">
        <property type="protein sequence ID" value="QAS61431"/>
        <property type="gene ID" value="EI377_12200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="138"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="312" mass="36687" checksum="D45460DBEA03ECE9" modified="2018-12-05" version="1">MSSLGNLLKMLYILKRGQKVKVKDLAEELEVDHRQIRRYKEELSEYFDIQSITGPNGGYILCDEYFPFKDILTEKEINNLKRAIDTVSYSEEYELGKAIDKINFTILNSQSESLISEQIIPYSRPKMEIEKINKMYNEINLSILSCKEIIIVYVDNKGSLTRRAIQPHKFLRFKGEYYIIATCKLRNEIRYFKLVRIKEYILTEKRFEKMKNIDELINEYKENSIGIFGGNEIEVELEINPPMANTIKERIWVDNQEVIELEDGKILFKAIMKLGPELISWVLSMGDSVKINSSEELKRQVRIKVENIFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBZ2</accession>
    <name>A0A386PBZ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">CP523_01785</name>
        <name evidence="11" type="ORF">EI377_12305</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677313.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02394"/>
    <dbReference type="EnsemblBacteria" id="AYE33280">
        <property type="protein sequence ID" value="AYE33280"/>
        <property type="gene ID" value="CP523_01785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61451">
        <property type="protein sequence ID" value="QAS61451"/>
        <property type="gene ID" value="EI377_12305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01785"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01415">
        <property type="entry name" value="SAICAR_synt_PurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033934">
        <property type="entry name" value="SAICAR_synt_PurC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="26926" checksum="236E6B62DFBED4B9" modified="2018-12-05" version="1">MERLEMMYEGKAKKIYATENKDEVIVYYKDDATAFNGEKKGSIEDKGVLNNAITSMLFEMLNENGIKTHFLKKLSDREQLCKKVEIVPLEVIVRNVAAGSMAKRLGLEEGFELKTTVFELSYKDDSLGDPLINDYHAVGIGATTFEELEKIYDMTAKINELLKKFFMEQNIRLIDFKLEFGKYNGEIVLADEISPDTCRFWDAKTGEKLDKDRFRRDLGNVKDAYVEILNRITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC74</accession>
    <name>A0A386PC74_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">CP523_03210</name>
        <name evidence="18" type="ORF">EI377_13725</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677252.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02141"/>
    <dbReference type="EnsemblBacteria" id="AYE33545">
        <property type="protein sequence ID" value="AYE33545"/>
        <property type="gene ID" value="CP523_03210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61708">
        <property type="protein sequence ID" value="QAS61708"/>
        <property type="gene ID" value="EI377_13725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03210"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="170"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="310"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="177"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS61708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="46463" checksum="EBC879169C56EE3F" modified="2018-12-05" version="1">MIQLVGIKKNIDIEIREKLALHSKKQENYTKELLNYFDEVVIISTCNRTEIYFNGSLSGEEGLKKVFEIFKWDINLSKYCFYLDEKETVKHLMEVVCGFHSRILGEDQILGQIKSAYQKSLEMGAVKLELQRLFQDAITCGKRFRTEGRLYEIPVSSSSIAVNDAINKGAKKFMVIGYGEVGTLVVKYALSHNIDSLKLVVRDITKIEYIDDIRVEVMDYKHGREIINDMDCVISCTSAPHLIIEQKHIKEYGDRLIIFDLAVPRDVDEKVKNFNRVELLDIDDISSIDDENKKLRDERMQYFKYIPYQYIKEFLEWKKLRGIAQNIKELKISGNKVVEERCKTFSHKCKNPQDIQLANVLIKSTSDAYVNRAIEVLKEEKLKGCEEECLRILKRIFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCD8</accession>
    <name>A0A386PCD8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03645</name>
        <name evidence="2" type="ORF">EI377_14175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677720.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33623">
        <property type="protein sequence ID" value="AYE33623"/>
        <property type="gene ID" value="CP523_03645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61787">
        <property type="protein sequence ID" value="QAS61787"/>
        <property type="gene ID" value="EI377_14175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="102" mass="11617" checksum="2EBF99B3763474E9" modified="2018-12-05" version="1">MTIYAITYYLKENSHSCGCGDEHHHHHHHTRDDYAITGNIKALGGWAHLMPTSFLVKTDLSAEEILVKLKEFIEEKDLLFITEVNKDNVASLTPGVVEWINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCS8</accession>
    <name>A0A386PCS8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04430</name>
        <name evidence="3" type="ORF">EI377_14975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676434.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33773">
        <property type="protein sequence ID" value="AYE33773"/>
        <property type="gene ID" value="CP523_04430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61931">
        <property type="protein sequence ID" value="QAS61931"/>
        <property type="gene ID" value="EI377_14975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="103" mass="11799" checksum="B81C23BD59C1EADB" modified="2018-12-05" version="1">MFFRIFGIALIGFSIWGLIFTCINRKDMPNSIFALKPNSYEVIENVKFNNLMIYKSLILSILFLISGILCVCIQGIESFIPIYIGTLIQSVLGIRSKKYIRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCZ1</accession>
    <name>A0A386PCZ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ATP-dependent Clp protease ATP-binding subunit ClpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_01330</name>
        <name evidence="8" type="ORF">EI377_11830</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675569.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00817"/>
    <dbReference type="EnsemblBacteria" id="AYE33194">
        <property type="protein sequence ID" value="AYE33194"/>
        <property type="gene ID" value="CP523_01330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61364">
        <property type="protein sequence ID" value="QAS61364"/>
        <property type="gene ID" value="EI377_11830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="198"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="478"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="6">
        <location>
            <begin position="645"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="737" mass="83039" checksum="C533344B514B1927" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD43</accession>
    <name>A0A386PD43_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_05150</name>
        <name evidence="10" type="ORF">EI377_15710</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676217.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01819"/>
    <dbReference type="EnsemblBacteria" id="AYE33905">
        <property type="protein sequence ID" value="AYE33905"/>
        <property type="gene ID" value="CP523_05150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62056">
        <property type="protein sequence ID" value="QAS62056"/>
        <property type="gene ID" value="EI377_15710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS62056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="228" mass="26348" checksum="0C0B5AC83B240CFE" modified="2018-12-05" version="1">MKRIFFVEDDLSLINGLSFAIKKQGYEIDIARTSLEAKKLWMDRKYDLVILDVSLPDGSGYDLCKYIRKTSKVPIIFLTAADEETDIIMGLDIGGDDYITKPFKLAVFLSRINALLRRSDNFNEADTELNSNGIKVQLLKREVYNNGIQIYLTASEYKLLCLFIENPDIVLSPEQILSKLWDCDEKYIDSNTLTVYIRRLRTKIEDNPGQPQKIVTVRRMGYKWNTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD77</accession>
    <name>A0A386PD77_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MBL fold metallo-hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MBL fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00095</name>
        <name evidence="4" type="ORF">EI377_10575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00294"/>
    <dbReference type="EnsemblBacteria" id="AYE32961">
        <property type="protein sequence ID" value="AYE32961"/>
        <property type="gene ID" value="CP523_00095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61133">
        <property type="protein sequence ID" value="QAS61133"/>
        <property type="gene ID" value="EI377_10575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362694" evidence="1">
        <location>
            <begin position="28"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="42"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="337" mass="37124" checksum="6510FC9B1A316A04" modified="2018-12-05" version="1">MNKVRNLLSLFLIIMISLFGVPLNANAQIQENVIVNYIDVGQGDSELIQISGKNILIDAGNNDDLAYNYLKNLGITKLDYVIATHPHSDHIGGMATIIDNFDIGTFYAPKVTATTRVFERMVTALNNKNVKIKVPKVGDTLNIGNVTLEFLAPNSPKYRKVNNYSIVTKLKYGNTSFIFTGDAESLSEGEILQKQLDISADVLKLGHHGSRTSTSKGFLNAVNPKYAIVSAGKGNDYGHPHEETIKKLNEKNIQVFRTDISGTIIAVSNGSTINFTNEDDTSSSIEKETSDNSVWIANNKSKVYHSNNNCSKMKNPIKILLEDAKNRGLRPCSRCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDE1</accession>
    <name>A0A386PDE1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_04645</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33810">
        <property type="protein sequence ID" value="AYE33810"/>
        <property type="gene ID" value="CP523_04645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="PTHR24348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="512" mass="59856" checksum="378630F0E4439154" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDR1</accession>
    <name>A0A386PDR1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-type HAD-IIB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05285</name>
        <name evidence="2" type="ORF">EI377_15845</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676270.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01845"/>
    <dbReference type="EnsemblBacteria" id="AYE33930">
        <property type="protein sequence ID" value="AYE33930"/>
        <property type="gene ID" value="CP523_05285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62081">
        <property type="protein sequence ID" value="QAS62081"/>
        <property type="gene ID" value="EI377_15845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="30593" checksum="386133127DC2FA97" modified="2018-12-05" version="1">MKDCKGIVFFDVDGTLIDCFKGISAPTESTRNSIKKLKENKFLTILATGRPKSCIDENLLNLGLDGYIASNGAYADFKEDIIFDYPIDNEKLNEILDYFKENNIDYMLEGHEMNYISSYENKKLMDLLEGAKLNMDYITDKWDRSKVKTSKIIIVNNENNEIFEKVSEKYKDGFTFMKHPMGVSFEMYLSKYTKGYGVEQLVNKLGIDMDKTYAFGDGENDIEMFQVVKHGIAMGGYHEKLEAVAYDFTEDVENEGITKGLEKLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDR3</accession>
    <name>A0A386PDR3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_06480</name>
        <name evidence="14" type="ORF">EI377_00960</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677442.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02173"/>
    <dbReference type="EnsemblBacteria" id="AYE34143">
        <property type="protein sequence ID" value="AYE34143"/>
        <property type="gene ID" value="CP523_06480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59511">
        <property type="protein sequence ID" value="QAS59511"/>
        <property type="gene ID" value="EI377_00960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="12">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="11">
        <location>
            <begin position="201"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS59511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="296" mass="33024" checksum="A67985E1968A8DA0" modified="2018-12-05" version="1">MKINTIKYFIIDALKSLKRNRGISVAAMITVLITFFVFGTFTLLALNFNKAIEDVASKVEIKVFLKDDIKLVDQREIEVKLNEQQGIKDVIYESKDEAFLNFKESLSNNEGLLQGYDLQNNPLPSSFIVKLQDPDYAESVGDAVKSMTGVESIENQRDLINKISSVVKGFQAIGLVLFGIFAGVSVFLITNTIKIAVYSRRREVGIMKFVGATDWFIRWPFIIEGIIIGSIGSLLSSVVLFFGYKFTYGYIVSNMFLVTLVPPTFVFTTLIWLFLGGGIVVGAIGSFVALRKFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDY0</accession>
    <name>A0A386PDY0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartokinase</fullName>
            <ecNumber evidence="12">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dapG</name>
        <name evidence="16" type="ORF">CP523_00625</name>
        <name evidence="17" type="ORF">EI377_11115</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676360.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00656"/>
    <dbReference type="EnsemblBacteria" id="AYE33058">
        <property type="protein sequence ID" value="AYE33058"/>
        <property type="gene ID" value="CP523_00625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61227">
        <property type="protein sequence ID" value="QAS61227"/>
        <property type="gene ID" value="EI377_11115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00625"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ACT_7" evidence="15">
        <location>
            <begin position="332"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="400" mass="43405" checksum="9F95C1837216FF8C" modified="2018-12-05" version="1">MKIIVQKFGGTSVSTEERREQVILKVKEAITNGYSPVVVVSAMGRKGAPYATDTLLSLLDNNFKRENLQATDMLMSCGEIISSVVMTNALVSAGIQAVPLTGGQAGIITNDKFTEAQFTETHPELILSIVKQGKVPIVTGFQGVTEKGYFTTLGRGGSDTSACILGIALKAEAVEIYTDVDGIMTADPRIVNNASLIDVISYNEVFQLADQGAKVIHPKAIELARKGNIPLVIKNTMSNCKGTLINNLGSDHIGNALSGITHLANRIQVRVRLKDNKEQASYRQLLDILAQNHISLDLINIFPEEQIFTIDSCEKEVLEKILSEAKIKYNIIENCSTIAMVGAGMTGVPGIMAKIINTLMLNNIEVLQTADSHMTIWCLIYSDKVSEAINLLHKAFNLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDZ7</accession>
    <name>A0A386PDZ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 8 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">pgk</name>
        <name evidence="13" type="ORF">CP523_03980</name>
        <name evidence="14" type="ORF">EI377_14500</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 8 11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679263.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01947"/>
    <dbReference type="EnsemblBacteria" id="AYE33687">
        <property type="protein sequence ID" value="AYE33687"/>
        <property type="gene ID" value="CP523_03980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61842">
        <property type="protein sequence ID" value="QAS61842"/>
        <property type="gene ID" value="EI377_14500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03980"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="348"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="391" mass="42036" checksum="C7205C96FFF4F666" modified="2018-12-05" version="1">MNFNKKTIEDIDVKGKRVLVRCDFNVPLKDGVITDENRLNGALPTIQYLIKNGAKVILCSHLGKDASKSLAPVAKRLSEMLNQEVVFARDEEVVGENAKKAVAEMKDGDVVLLENTRCRKEETKNVDEFSKELASLAEIFVNDAFGTAHRAHCSTVGVTNYLDTAVCGYLIQKELKFLGDAVNNPERPFVAILGGAKVSDKINVINNLLEKVDTLIIGGGMAYTFLKAQGYEIGTSLVEADRVDYAKEMIEKAAAKGVKFLLPVDHRVAAEFKDVEAVVTEDQNIPAGHMGLDIGPKTEALYADAIKDAKTVIWNGPMGVFEFENFNKGTIAVAKAMADADATTVIGGGDSAAAVNILGFGDKMTHISTGGGASLEFLEGKVLPGIEALNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE13</accession>
    <name>A0A386PE13_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_00830</name>
        <name evidence="10" type="ORF">EI377_11325</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674591.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02353"/>
    <dbReference type="EnsemblBacteria" id="AYE33098">
        <property type="protein sequence ID" value="AYE33098"/>
        <property type="gene ID" value="CP523_00830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61268">
        <property type="protein sequence ID" value="QAS61268"/>
        <property type="gene ID" value="EI377_11325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="344" mass="39746" checksum="96B77BA4F1AB686A" modified="2018-12-05" version="1">MSKKYYIIPIFISHQGCPHQCVFCNQNRIAKVVNDEVTGEDVKRTILEYLETINKNESTVEVSFFGGTFTAIDVSKQKELLAVAKDFKEKGFIHKIRMSTRPDAINDYILSYLKEYKVDIIELGVQSLDNYILKLSGRGHTSEDVYKASNLIKKYGFILGHQIMPGLPGDNFNKDIETVKKSIEMKPDLCRIYPSLVIKDTPMEEMYKRGEYVPYTLEEAVNVSKEMYKLYNKAKVQVIRIGLQPTESITWGKDIIDGPFHPAFRELVESNLMCDEIKKRVSEEDNIIIEVNPKDLSKLYANKKIYFNEFKNKHKGRIEVLTKDKLKRGTLRVIVVKKIEEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE21</accession>
    <name>A0A386PE21_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34263">
        <property type="protein sequence ID" value="AYE34263"/>
        <property type="gene ID" value="CP523_07270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="51" mass="5710" checksum="E0FF602A2CCBC570" modified="2018-12-05" version="1">MDSKNYKDLSKENYLKNGTKSQGQKAKNSFNTTIEKPALNESGLEAKKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE44</accession>
    <name>A0A386PE44_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter ATP-binding protein</fullName>
            <ecNumber evidence="7">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB</name>
        <name evidence="6" type="ORF">CP523_01035</name>
        <name evidence="7" type="ORF">EI377_11530</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674492.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02312"/>
    <dbReference type="EnsemblBacteria" id="AYE33138">
        <property type="protein sequence ID" value="AYE33138"/>
        <property type="gene ID" value="CP523_01035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61308">
        <property type="protein sequence ID" value="QAS61308"/>
        <property type="gene ID" value="EI377_11530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="28627" checksum="4C125BB49A0428DA" modified="2018-12-05" version="1">MSKDNLPKIRVRNLDLFYGDNQALKKIDLDIEENKVTAFIGPSGCGKSTFLRTLNRMNDLIESVKVTGEVLVDGEDIYKNSDVIALRTKVGMVFQKPNPFPMSIYDNIAYGPRLHGIKDKKTLDEIVEKSLKGAALWDEVKDRLKKSALGLSGGQQQRLCIARTIAVSPEIILMDEPTSALDPISTNKMEELMDELKEKYTVIIVTHNMQQAGRIADKTAFFLNGEVIEYGNTEDIFYKPKDKRTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB0</accession>
    <name>A0A386PEB0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 9" type="primary">grpE</name>
        <name evidence="8" type="ORF">CP523_02275</name>
        <name evidence="9" type="ORF">EI377_12795</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674014.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00512"/>
    <dbReference type="EnsemblBacteria" id="AYE33371">
        <property type="protein sequence ID" value="AYE33371"/>
        <property type="gene ID" value="CP523_02275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61541">
        <property type="protein sequence ID" value="QAS61541"/>
        <property type="gene ID" value="EI377_12795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="204" mass="23441" checksum="9CEFC224444085F3" modified="2018-12-05" version="1">MEDNKEFKEEVKDENIEVEENDIEVEECDSCQDESSEENIPEEKESKDGWNPLKTMKKLKEDNKKLSNEVEALKDRLLRISAEYENYRKRTIKEKEGIYTDACTDVLKEMLPVLDNLERALLADGSIEDVKKGIEMTIKGVSGSFEKLGVEEIDATGEFDPNLHQAVMHVQDENLEANMVAEVFQKGYKRGDKVIRYTMVKVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED6</accession>
    <name>A0A386PED6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33817">
        <property type="protein sequence ID" value="AYE33817"/>
        <property type="gene ID" value="CP523_04685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="184" mass="22307" checksum="DF4054FD9D551839" modified="2018-12-05" version="1">MNFYLDKLTVDYCFQSKDYISFEILPYENPYYDVEDIESEELIYRDEYVDSCIDCACKVWNSCNFSDNLAVIYEDKYNESKKRENEFIEMYLESTECTTFPFEWIDDEEKYYGTRYIWETNRINIEKLFRKIIISDIGDNTELDCAVYIIDKETDNVFFLYDDRGIHVFSNDCTFIEKLKQIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED8</accession>
    <name>A0A386PED8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease P</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">TIGR04540 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00460</name>
        <name evidence="2" type="ORF">EI377_10950</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676300.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00621"/>
    <dbReference type="EnsemblBacteria" id="AYE33026">
        <property type="protein sequence ID" value="AYE33026"/>
        <property type="gene ID" value="CP523_00460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61195">
        <property type="protein sequence ID" value="QAS61195"/>
        <property type="gene ID" value="EI377_10950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030902">
        <property type="entry name" value="CLB_0814_fam"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04540">
        <property type="entry name" value="CLB_0814_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="77" mass="8947" checksum="5242468484C19C45" modified="2018-12-05" version="1">MRVVYRNPKELATHLKDLVDLYLEDLLSYNELEGKVIKIIKANEDRVYKGNTMPTKLANVLGNERVEIINEIFSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH6</accession>
    <name>A0A386PEH6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xpt</name>
        <name evidence="3" type="ORF">CP523_08390</name>
        <name evidence="4" type="ORF">EI377_03135</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674787.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01619"/>
    <dbReference type="EnsemblBacteria" id="AYE34445">
        <property type="protein sequence ID" value="AYE34445"/>
        <property type="gene ID" value="CP523_08390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59848">
        <property type="protein sequence ID" value="QAS59848"/>
        <property type="gene ID" value="EI377_03135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08390"/>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="190" mass="21658" checksum="62D9B3AB879EEF83" modified="2018-12-05" version="1">MEALKKKILEEGKIREGNILKVDCFLNHQMDIKFFNEIGKEFKNRFKDQKIDKILTIEASGIGIAAIVSQYFDYAPVVFAKKTESLNLDKEVYESEVHSFTKKKTYKVRVGKEFINKDENILIIDDFLAQGCATKGMIDIVKQADANIVGAGIVIEKGFQEGRKVLEEMGIRVESLAIIDRFENNTLIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI0</accession>
    <name>A0A386PEI0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aconitate hydratase A</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Iron-responsive protein-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RNA-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_08380</name>
        <name evidence="15" type="ORF">EI377_03125</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01617"/>
    <dbReference type="EnsemblBacteria" id="AYE34443">
        <property type="protein sequence ID" value="AYE34443"/>
        <property type="gene ID" value="CP523_08380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59846">
        <property type="protein sequence ID" value="QAS59846"/>
        <property type="gene ID" value="EI377_03125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08380"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="13">
        <location>
            <begin position="516"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS59846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="639" mass="69801" checksum="5557F26FDEC5A297" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI3</accession>
    <name>A0A386PEI3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">rbfA</name>
        <name evidence="2" type="ORF">CP523_00665</name>
        <name evidence="3" type="ORF">EI377_11155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676374.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00664"/>
    <dbReference type="EnsemblBacteria" id="AYE33066">
        <property type="protein sequence ID" value="AYE33066"/>
        <property type="gene ID" value="CP523_00665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61235">
        <property type="protein sequence ID" value="QAS61235"/>
        <property type="gene ID" value="EI377_11155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="116" mass="13387" checksum="207CD7AFC553301B" modified="2018-12-05" version="1">MASYRGGRINEEVKKEISVIIRDEIKDPRMTAMVSVTAVEVTKDLRYAKVFVSVFGKNEEEKTETFKALKSASGYIRREIGRRVNLRNTPQIIFELDESIGYGMRIDELIERAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV4</accession>
    <name>A0A386PEV4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05505</name>
        <name evidence="2" type="ORF">EI377_00125</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33967">
        <property type="protein sequence ID" value="AYE33967"/>
        <property type="gene ID" value="CP523_05505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59358">
        <property type="protein sequence ID" value="QAS59358"/>
        <property type="gene ID" value="EI377_00125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="115" mass="13156" checksum="9E2A9A9FD761F906" modified="2018-12-05" version="1">MNNIIKVNGNELSIDSKIIKFNYDIRDTKLVNNQVIVLLSIPFNVNEIDNIYAVSLDGKINWKVESLSVINPNGNNLPYENMFLNNEELTATDFYGRRYFINTTNGAIVKKDIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV8</accession>
    <name>A0A386PEV8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09135</name>
        <name evidence="9" type="ORF">EI377_03880</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell membrane</location>
            <topology evidence="2 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678393.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00265"/>
    <dbReference type="EnsemblBacteria" id="AYE34573">
        <property type="protein sequence ID" value="AYE34573"/>
        <property type="gene ID" value="CP523_09135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59973">
        <property type="protein sequence ID" value="QAS59973"/>
        <property type="gene ID" value="EI377_03880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030946">
        <property type="entry name" value="EcfA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04521">
        <property type="entry name" value="ECF_ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="32194" checksum="C1AB0440B5DE15F3" modified="2018-12-05" version="1">MSIKIENLTHIYMPKSPFEKVALNNVNIEINEGEFIALIGHTGSGKSTLIQHMNGLLKPSSGRIIVDDMDITSSNVNLSNVRKKVGLVFQYPEYQLFEETIEKDIEFGPRNLKLDQEEITKRVKKSMEMVGLDYEVYKDKSPFDLSGGQKRRVAIAGVIAMEPKVLILDEPTAGLDPKGRDDILGQIKLLHDKYKMTIVLVSHSMEDVGKLAERIIVMNKGTVALQGKPSEVFKEIDTLESIGLAVPQVTYLMRELRRKGFNVSDDIYTINQAKDELIKSLKCNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW5</accession>
    <name>A0A386PEW5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoaspartyl dipeptidase</fullName>
            <ecNumber evidence="2">3.4.19.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iadA</name>
        <name evidence="7" type="ORF">CP523_09245</name>
        <name evidence="8" type="ORF">EI377_03990</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Carboxylation allows a single lysine to coordinate two zinc ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M38 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678320.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03049"/>
    <dbReference type="EnsemblBacteria" id="AYE34595">
        <property type="protein sequence ID" value="AYE34595"/>
        <property type="gene ID" value="CP523_09245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59995">
        <property type="protein sequence ID" value="QAS59995"/>
        <property type="gene ID" value="EI377_03990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010229">
        <property type="entry name" value="Pept_M38_dipep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001238">
        <property type="entry name" value="IadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01975">
        <property type="entry name" value="isoAsp_dipep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="267"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="391" mass="42563" checksum="3D16474223E94EED" modified="2018-12-05" version="1">MITIIKGIKIYAPDYRGIKDVVVLGDKIEDIFDDIQIPEKFVEIDVIDGRNKILFPGFIDCHVHIIGGGGEGGFKTRTPEIPFTELTKAGITTVVGCIGTDGVCRNMRSLIAKAKALEEEGITTFCYTGSYEIPVKTITESIKGDLMMVDKVIGVGEVALSDNRSSQATFNEFVNTVAQARVGGLLSGKAGIVNVHLGDGARKLDYLFSLIEETEIPPTQLLPTHINRSRKLFKVGEEYVKKGGFIDLTTSSDPRFLEPGELRASDGLKELLNNGLDIEHITFSSDGNGSMPIFDVNGHLTGLGICKVSTLYGEVKESIKTHNIKIEDAIRVITSNVAKVLKLHNKGTIEKGKDADLVLVDENTLEIDKVFAKGKLMVNNGEAIIKGTFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ2</accession>
    <name>A0A386PEZ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01545</name>
        <name evidence="2" type="ORF">EI377_12065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675658.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33236">
        <property type="protein sequence ID" value="AYE33236"/>
        <property type="gene ID" value="CP523_01545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61408">
        <property type="protein sequence ID" value="QAS61408"/>
        <property type="gene ID" value="EI377_12065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="65" mass="7682" checksum="84A292EC00E91AEC" modified="2018-12-05" version="1">MVTKKQLKDDIITYDVITYKDEDGKKVEYVEVTLVDRIIDVYMDIREVNIGLIANKIIEDNLYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF21</accession>
    <name>A0A386PF21_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">8-oxoguanine DNA glycosylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DNA-3-methyladenine glycosylase 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09585</name>
        <name evidence="3" type="ORF">EI377_04330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676682.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02623"/>
    <dbReference type="EnsemblBacteria" id="AYE34655">
        <property type="protein sequence ID" value="AYE34655"/>
        <property type="gene ID" value="CP523_09585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60054">
        <property type="protein sequence ID" value="QAS60054"/>
        <property type="gene ID" value="EI377_04330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="124"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="314" mass="36686" checksum="9BDB08BE24124B6F" modified="2018-12-05" version="1">MDFKEAIFEENKVILKGIKNFNIKQILECGQCFRWDKITDNNYIIIAFGKVIEVYQNNDEVIILNSAKEDFENIWIKYFDLERDYGYIKSELAKDEILRKSVEFGYGIRILNQDPFEMLISFIISARNSIPSIKKTVKKICEKWGNKVIYKNEEYYTFPTPKEIKGATLDEIQTTGASFRSKYIVNTIERVNEAIEIKEDIKVNPDKYLDNPEILDYDLEYITNLSDDECHIALQKFMGVGAKVADCIMLFSMAKHSAFPVDVWVKRAMIHFYVAPDVSLNKMRIFARDKFGALSGMAQQYLFYYARENKINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF54</accession>
    <name>A0A386PF54_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3006 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06075</name>
        <name evidence="2" type="ORF">EI377_00555</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675111.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34067">
        <property type="protein sequence ID" value="AYE34067"/>
        <property type="gene ID" value="CP523_06075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59438">
        <property type="protein sequence ID" value="QAS59438"/>
        <property type="gene ID" value="EI377_00555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021377">
        <property type="entry name" value="DUF3006"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11213">
        <property type="entry name" value="DUF3006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="8460" checksum="57D8669927BC1A44" modified="2018-12-05" version="1">MDSFIIDRIEENYVVLETEAENIININKDLVKGNFNEGDVLIKKGDIYIVDPILTKNRRDKIKNMMKGMWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF92</accession>
    <name>A0A386PF92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation peptidase YabG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yabG</name>
        <name evidence="1" type="ORF">CP523_10035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676565.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00336"/>
    <dbReference type="EnsemblBacteria" id="AYE34713">
        <property type="protein sequence ID" value="AYE34713"/>
        <property type="gene ID" value="CP523_10035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008764">
        <property type="entry name" value="Peptidase_U57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05582">
        <property type="entry name" value="Peptidase_U57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011575">
        <property type="entry name" value="YabG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02855">
        <property type="entry name" value="spore_yabG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="294" mass="33071" checksum="3BE83854501348B1" modified="2018-12-05" version="1">MVIGDLVVRKSYDKDITFKIIDIKEDEEGNPIYILKGISIRIIADSAKDDLQKVDDDFVGEKEKILNTRVSEAINKAISLRGDVRAMKAINSRSSKNLKESPNKELIFGRPGKILHIDGDREYLETCLKVYKQLSLDAIGISISEREQPKKVVDLVKEIKPDIVVLTGHDGVLRVTDDYLNLDNYRNSKYYIESVRALRNYNSSYDELVIFAGACQSCYECMLDAGANFASSPNRVLIHCLDPVFVCEKIAYTRIDKVVSITDVIDNTITGIKGIGGLQTRGKYREGYPKSSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC0</accession>
    <name>A0A386PFC0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_05305</name>
        <name evidence="5" type="ORF">EI377_15865</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676278.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01849"/>
    <dbReference type="EnsemblBacteria" id="AYE33934">
        <property type="protein sequence ID" value="AYE33934"/>
        <property type="gene ID" value="CP523_05305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62085">
        <property type="protein sequence ID" value="QAS62085"/>
        <property type="gene ID" value="EI377_15865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788309" evidence="3">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="278" mass="30389" checksum="1D3234223A23619D" modified="2018-12-05" version="1">MKRIIKGLAISLVAGVIFLSPVRSVSASTGIVLERVEKEANVVEVSIDNFNYEAKSFQLELKIVGDVTLADLKWSEALNKSVVNKNYIYNKDKNTINIYVTSKENLVEFSKLPVCTLTVNGEANTTYNIVSGKSFKYIYSNKNKEGKIDEIPSDSEVNFNYVYKDNNTEKPDGSEKPDGTEKPDEGEKPSGDENQESDGNLENQGKPENTGGQGNSSENGNSNSNNSSNKSEVKNEDESKDSKGLYTGDIIGAVVAISGVSLAGAYVFRPKRKNESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD0</accession>
    <name>A0A386PFD0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transketolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Transketolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06500</name>
        <name evidence="7" type="ORF">EI377_00980</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677449.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02177"/>
    <dbReference type="EnsemblBacteria" id="AYE34147">
        <property type="protein sequence ID" value="AYE34147"/>
        <property type="gene ID" value="CP523_06500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59515">
        <property type="protein sequence ID" value="QAS59515"/>
        <property type="gene ID" value="EI377_00980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="5">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="33982" checksum="62B5E2BF3E30BE85" modified="2018-12-05" version="1">MSKKIATREAYGKALAKLANTNKNVVVLDADLSKSTKTADFKATCPERFFNMGIAEANMMGVAAGLSTCGKIPFVSTFAMFASGRAFEQIRNSICYPKLNVKICATHAGLTVGEDGASHQAIEDLAIMRSIPNMTVICPADAVETEAAIKAIAEYNGPCYVRLGRAPVNVINNPETYEFKIGKGVRLSDGNDVTIVATGIMVDLALEAKEELLKENINARVINIHTLKPIDKEILINAAKETGAIVTVEEHNIVAGLGSAVLEAISEECPVSVFRIGVKDVFGESGKPDELLKAYGLTTTNIVDKVKKAVKIKNCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN3</accession>
    <name>A0A386PFN3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:alanine symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_02075</name>
        <name evidence="10" type="ORF">EI377_12595</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33332">
        <property type="protein sequence ID" value="AYE33332"/>
        <property type="gene ID" value="CP523_02075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61502">
        <property type="protein sequence ID" value="QAS61502"/>
        <property type="gene ID" value="EI377_12595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="457" mass="48475" checksum="5C98564393C4FFFE" modified="2018-12-05" version="1">MNQIQSFLQSIDNIVWGPPLLILLVGTGIYLTYKLKLLQILKLPLALKYVFSKDEEVNDENAKGDVSSFGALCTALSATIGTGNIVGVATAIKAGGPGALFWMWIAAFFGMATKYAEGVLAIKYREVDENGEMAGGPMYYIKNGLGLNWLAKMFAVFGVGVALLGIGTFGQVKSIADAAQITFKVPLVVTAIVVTILVSLVTLGGIKRISKVSEKVVPIMAGLYIVSVLLVLIFNFTQIPEAISIIIKSAFNPQAALGGAVGITISIAMQRGIGRGVFSNEAGLGSAPIAAAAAKTKSPVRQGLISMTGTFIDTIIICTMTGLVIVITGAFNGPLEGAALTTSAFELGLPIAFVGKYIVNIGLIFFAFTTILGWNYYGERCIEYLMGVKAILPYKIVFIGFVAVGSFLPVELIFIIADIVNGLMALPNLIGLIGLRNVVIEETEEFFEEMKAESLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP1</accession>
    <name>A0A386PFP1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">CP523_07165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673720.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01048"/>
    <dbReference type="EnsemblBacteria" id="AYE34247">
        <property type="protein sequence ID" value="AYE34247"/>
        <property type="gene ID" value="CP523_07165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07165"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="244" mass="28485" checksum="CE2AF6CA95727539" modified="2018-12-05" version="1">MKKIVLIRHGQSLWNLENRFTGWTDVDLSDNGLIEARKAGRILKENGFTFDLAYTSVLKRSIRTLWIVLHEMDLMWIPVYKSWKLNERHYGALQGLNKEETAKKYGEEQVHKWRRFVNETPPKLEKSDPRYAGNEIKYKNLSEDKIPLTENLSDTEKRVLDEWNNVIVPKLKENKKIIISAHGNTLRALVKYLDDLSSDGIANLNIPTGTPLVYELDDNFNPIKHYYLSLDGKVPKEKTEKYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP7</accession>
    <name>A0A386PFP7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">sfsA</name>
        <name evidence="4" type="ORF">CP523_06110</name>
        <name evidence="5" type="ORF">EI377_00585</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675125.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01922"/>
    <dbReference type="EnsemblBacteria" id="AYE34074">
        <property type="protein sequence ID" value="AYE34074"/>
        <property type="gene ID" value="CP523_06110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59444">
        <property type="protein sequence ID" value="QAS59444"/>
        <property type="gene ID" value="EI377_00585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="3">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="2">
        <location>
            <begin position="81"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="26483" checksum="9B10FECEE25CDDB1" modified="2018-12-05" version="1">MKYNKNIYEAIFVKRPNRFNAEVILNGEHITVHVPNTGRCRELLIEGATVFLREELNPNRKTKYDLVAVIKGNNLISIDSQIPNKVVFEALSEGKIEKLKKYCNILKEKTFGKSRFDFKLSTEDQEEEYFLEVKGVTLEEDGYARFPDAPTERGARHILELIEAKREGYKAGILFLIQLENVNKFSPNDMTDPDFGEALRLADKNGVDIFAYNCKVHKDGIIINNIVEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS1</accession>
    <name>A0A386PFS1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hrcA</name>
        <name evidence="7" type="ORF">CP523_02280</name>
        <name evidence="8" type="ORF">EI377_12800</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674013.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00511"/>
    <dbReference type="EnsemblBacteria" id="AYE33372">
        <property type="protein sequence ID" value="AYE33372"/>
        <property type="gene ID" value="CP523_02280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61542">
        <property type="protein sequence ID" value="QAS61542"/>
        <property type="gene ID" value="EI377_12800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="106"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="343" mass="38860" checksum="A5B0381314AFCC0A" modified="2018-12-05" version="1">MAIDERKIKILQAIINDYIMTGEPVGSRTIAKRYNLGVGSATIRNEMADLEEMGYLEQPHTSSGRIPSNKGYRLYVDKLMNAEALSREEELKIKEYIINSAMYEVDKIVKQACSLLSELTNLTCIVETPSVKRSYIKSIQLLVIDSYNLVSVIVADSGVIKNHRIRVSEMPEIETLQRINEILNLRLKNLTIEEINLEVINNLKNELEGYDELFNAILPALYETLKEVNHSDILVEGATNIFNYPEYNDIEKAKEILSLINDKDCVIELLESPEGISIKIGEENYFPEAKECSVISAEYSLDGRPIGTIGLIGPRRINYSKVIAIMGQVMKELNRSLRNQIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ6</accession>
    <name>A0A386PFZ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-ribose ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Ribose ABC transporter substrate-binding protein RbsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rbsB</name>
        <name evidence="3" type="ORF">CP523_03500</name>
        <name evidence="4" type="ORF">EI377_14025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677915.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02251"/>
    <dbReference type="EnsemblBacteria" id="AYE33596">
        <property type="protein sequence ID" value="AYE33596"/>
        <property type="gene ID" value="CP523_03500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61760">
        <property type="protein sequence ID" value="QAS61760"/>
        <property type="gene ID" value="EI377_14025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362750" evidence="1">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="305" mass="32783" checksum="0C8914D585C36D8F" modified="2018-12-05" version="1">MKRKALKILAISLVSALSISIFAGCSRKEEKKKIGMVLSTLNNPFFVSMKDGAEKRAEELGYKLIVLDSQNDPAKERANVEDLIESGVITLLINPTDSDAVSTSIKVANEKKVPVITLDRQANEGEVTSHIASDNVKGGNMAAEFALEKLKDKEHIKAIEIQGVPGASATRDRGKGFNDIVNSNSNIEIVSSQSADFDRQKGLQVMENIIQAIPEFDVVFAHNDEMALGAAKAIKTANKKVILIGFDGNADAEDAILKGDMTATVAQQPDVIGALGVDISKKIDSGEKVDKEIPASLKILIKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG31</accession>
    <name>A0A386PG31_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11635</name>
        <name evidence="2" type="ORF">EI377_06450</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673365.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35015">
        <property type="protein sequence ID" value="AYE35015"/>
        <property type="gene ID" value="CP523_11635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60408">
        <property type="protein sequence ID" value="QAS60408"/>
        <property type="gene ID" value="EI377_06450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="16438" checksum="0043F629E519BF30" modified="2018-12-05" version="1">MINITQLNAEDIRSIVNLKGKEKGFQVTNLVINDTLNFSGTLNGILNGKVTGDVGIKGIKDEKLILQVFDLKLSSFGIFKANTSLIMKAISKLAKEHEVEVEGNKFLVQVDKIKEEMKMLETIIEDIYIENNHLNIVGENLNDYLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG35</accession>
    <name>A0A386PG35_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIID</name>
        <name evidence="3" type="ORF">CP523_10220</name>
        <name evidence="4" type="ORF">EI377_05025</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674326.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01451"/>
    <dbReference type="EnsemblBacteria" id="AYE34750">
        <property type="protein sequence ID" value="AYE34750"/>
        <property type="gene ID" value="CP523_10220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60150">
        <property type="protein sequence ID" value="QAS60150"/>
        <property type="gene ID" value="EI377_05025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014225">
        <property type="entry name" value="Spore_II_D_firmicutes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02870">
        <property type="entry name" value="spore_II_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="348" mass="38976" checksum="B51D1E564D31A12F" modified="2018-12-05" version="1">MNKRVKLPEGIMMLVTISILVLFFMIGIPIMVINSDSKSEKKESPKAPKVVTENATYIEIKGSDIIKVFIENENKVVEVPLEDYVKSVVSGEMPASFELEALKAQAIAARTYVATKKIKPCVKAEKAGGDVCDSTHCQVYISKESRLEKWSEKDRDNNWKKIEEAVNETKGQVLTYNGNLVMYPQFFATSSGKTENSVDVFSNDVPYLVSTESLGEEIAPKFKSEKSIGIDEFINIINSNYEKSGLNINNLSGNIEIISKSDAGGVKEIRIGKERIKGTEFRHLLKLNSTNFEFDISESEIIFKCKGYGHGVGMSQWGANVMAKEGKNFKEILSHYYTDTQLKDIEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG53</accession>
    <name>A0A386PG53_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF348 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_08300</name>
        <name evidence="5" type="ORF">EI377_03045</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674745.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01601"/>
    <dbReference type="EnsemblBacteria" id="AYE34427">
        <property type="protein sequence ID" value="AYE34427"/>
        <property type="gene ID" value="CP523_08300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59830">
        <property type="protein sequence ID" value="QAS59830"/>
        <property type="gene ID" value="EI377_03045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="158"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="38486" checksum="46E5F42E0C8A675B" modified="2018-12-05" version="1">MVEKYKEYLKKNFSNGPKAKILLGVIVIGILAVTFINMRKTVTVSIDGKEETFVTYKGTVKDVLTTKGVEIASKDKVKPALDSKVKEYTNISIKKAIPVELSVSNKNITIDTAEDTIGDMLKAEVEELKNEGIEYKEGVDEITPSVDTKIAKDLKIQIVKVHIKEEIAREAIAFDVVEESDANLDVSVEEVRQDGAAGEKEVAYEVIYKDGKEVSRNIKSSKVITEPVNKIIVQGTRQSFASRDGQILDYKKLIYCESTAYYGDGITATGTIPVRNVNGLSTISVDPRVIPLGSLVYVEGYGKAIASDTGGAIKGNIIDVFVNSHDEAFSWWGRRYDVPVYILAYPGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG99</accession>
    <name>A0A386PG99_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YdcF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03300</name>
        <name evidence="4" type="ORF">EI377_13815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677223.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02124"/>
    <dbReference type="EnsemblBacteria" id="AYE33562">
        <property type="protein sequence ID" value="AYE33562"/>
        <property type="gene ID" value="CP523_03300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61725">
        <property type="protein sequence ID" value="QAS61725"/>
        <property type="gene ID" value="EI377_13815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="93"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="250" mass="28450" checksum="84E6477BFF60E714" modified="2018-12-05" version="1">MEKLKKNINLIIGIVLCIYVVLINLICGKVSFSYSFFILGIILIIYHFIKDKIKGINKVLKVVKPIILVFIIIFITIEAAIILYPKKNIDKADYMIILGAGLKGEKLSMTLEQRLNKALEYIENYDNGINIVVSGGQGPGEDITEAEAMKRYLIKNGVKEDNIIMENKSTSTSENLIYSKEKIENIVDGKIKSVKIKVVTSDFHAFRSNMLAKRNGYEKISFYTNNTFFPLIPIMYTREFLAVIKSYILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB2</accession>
    <name>A0A386PGB2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-4 C(11)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobM</name>
        <name evidence="7" type="ORF">CP523_01460</name>
        <name evidence="8" type="ORF">EI377_11980</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675620.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00844"/>
    <dbReference type="EnsemblBacteria" id="AYE33219">
        <property type="protein sequence ID" value="AYE33219"/>
        <property type="gene ID" value="CP523_01460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61391">
        <property type="protein sequence ID" value="QAS61391"/>
        <property type="gene ID" value="EI377_11980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01460"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="248" mass="27495" checksum="B554FEDF5072974F" modified="2018-12-05" version="1">MVYFIGAGPGDVDLITVKGRDILSKADIVIYAGSLVSSEHLEFCKKGVETFNSAKMTLDDVIKVIKENKDKLIVRLHTGDPSIYGAIKEQMDELSKLNIDYKVVPGVSSFTAAASAINREFTLPSITQTVILTRVEGRTPVPETEDLEKLASIGASMAIFLSISMIDKVVEKLRKGYGRNVPIAVVERATWNDERAIIGTLDDIAEKVKEAGIKKCAQILVGDFINCEYEKSLLYDKRFTHMYREAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC2</accession>
    <name>A0A386PGC2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase (symmetrical)</fullName>
            <ecNumber evidence="2">3.6.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10680</name>
        <name evidence="6" type="ORF">EI377_05465</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674141.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01366"/>
    <dbReference type="EnsemblBacteria" id="AYE34830">
        <property type="protein sequence ID" value="AYE34830"/>
        <property type="gene ID" value="CP523_10680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60225">
        <property type="protein sequence ID" value="QAS60225"/>
        <property type="gene ID" value="EI377_05465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="188" mass="21659" checksum="9F4830429AA165CA" modified="2018-12-05" version="1">MYDVNEIKNYLKNNLVESRFNHTLGVVETSIKLAKINDVDLNKAKIAALIHDVAKNKTVDEMKKIIDENKIKLSYDEENTPELWHSIIAPIIGREVFNIDDEEILSAVRWHTTGKENMSTLDKIVYIADMIEPNRRFPGVEKIRSTAFKNLDEGILMALTHTTRYLLDKGFTIDINSIKARNYLLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGK9</accession>
    <name>A0A386PGK9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675183.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01967"/>
    <dbReference type="EnsemblBacteria" id="AYE35215">
        <property type="protein sequence ID" value="AYE35215"/>
        <property type="gene ID" value="CP523_12720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="260" mass="28869" checksum="7E702A2C2A7FFA13" modified="2018-12-05" version="1">MAILEIKNLKKVYSTRFSGNKVEALRDISFSVENGEYIAIMGESGSGKTTLLNILASLDKSTSGEVLLKGKNITSIKEKDMAAFRRNHLGYVFQDFNLLDTFSLKDNIFLPLVLAGKKYKEMEERLKPIVDMIGIEDLLEKYPYEVSGGQKQRVAIARAIISSPELLLADEPTGSLDSKTTAEILDLFSNVNKLGQTILMVTHSTLAASHASRVLFIKDGKIFNQIYRGSMNNEKMYEKISDTLTILATGGSNNEKFNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ0</accession>
    <name>A0A386PGQ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnQ</name>
        <name evidence="5" type="ORF">CP523_06030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01907"/>
    <dbReference type="EnsemblBacteria" id="AYE34058">
        <property type="protein sequence ID" value="AYE34058"/>
        <property type="gene ID" value="CP523_06030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="240" mass="26448" checksum="F6656A8FCE1B989D" modified="2018-12-05" version="1">MIHVNDLHKSFGKNEVLKGVSEHIKKGEVVVVIGPSGSGKSTFLRCLNLLEQPTDGEIIFEEKSITNKKANINKIREKMGMVFQQFNLFPHKTVLENLTMAPLKVKKSSKVDAEKKAYDLLERVGLSSKATAYPASLSGGQKQRIAIARALAMEPDVMLFDEPTSALDPEMVGEVLNVMKGLAKEGMTMVVVTHEMGFAKEVGDRILFMDGGVIVEEGTPEEIFNNPKNSRTIDFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR9</accession>
    <name>A0A386PGR9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06130</name>
        <name evidence="3" type="ORF">EI377_00600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34078">
        <property type="protein sequence ID" value="AYE34078"/>
        <property type="gene ID" value="CP523_06130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59447">
        <property type="protein sequence ID" value="QAS59447"/>
        <property type="gene ID" value="EI377_00600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="7002" checksum="7BE7655F687F9D53" modified="2018-12-05" version="1">MNSIVFILVIASAVFVSFKMAEEKGQSKYIWSLATAMIGPFVIIVQYITHYFRNKNKLSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT5</accession>
    <name>A0A386PGT5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13150</name>
        <name evidence="2" type="ORF">EI377_07995</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35295">
        <property type="protein sequence ID" value="AYE35295"/>
        <property type="gene ID" value="CP523_13150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60684">
        <property type="protein sequence ID" value="QAS60684"/>
        <property type="gene ID" value="EI377_07995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="142" mass="16974" checksum="787DD6B3DBB6E208" modified="2018-12-05" version="1">MEFTTIEQFREQPIEVQKIFLDWWECDYGDLYYYNEDPHEYKDVEIIDNNLECDLNGDFDYFKSIGPIPLFTEGQLRKFIEDKTNGKVESYYAWDYYTIAIRDTGCGGDDPQYDTEETNLLQVYWKVACIIAEEKVQVSEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV5</accession>
    <name>A0A386PGV5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_06355</name>
        <name evidence="6" type="ORF">EI377_00825</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02430"/>
    <dbReference type="EnsemblBacteria" id="AYE34118">
        <property type="protein sequence ID" value="AYE34118"/>
        <property type="gene ID" value="CP523_06355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59484">
        <property type="protein sequence ID" value="QAS59484"/>
        <property type="gene ID" value="EI377_00825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="25326" checksum="AA475E21CB307344" modified="2018-12-05" version="1">MIQLKGINKYYISGEEKLHALKDINLKVEKGEFLAIMGPSGSGKSTMIKILGLLDNSFEGNYLLNNRDVRSLSDDKLTSFRNEKIGFVFQDFNLIKRLTIKENIELPMLYKGCTLRETGKRVRALLEKVKLEDKINKYPTQLSGGQQQRISIARSLVNNPEIIIADEPTGALDSHTSEEIMNIFKDLNKSGITIILITHDINVAKKADRMVRIFDGELKEGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY9</accession>
    <name>A0A386PGY9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">rsmG</name>
        <name evidence="3" type="ORF">CP523_07625</name>
        <name evidence="4" type="ORF">EI377_02315</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673851.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01134"/>
    <dbReference type="EnsemblBacteria" id="AYE34321">
        <property type="protein sequence ID" value="AYE34321"/>
        <property type="gene ID" value="CP523_07625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59716">
        <property type="protein sequence ID" value="QAS59716"/>
        <property type="gene ID" value="EI377_02315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="239" mass="26946" checksum="303C60F571E0DBAD" modified="2018-12-05" version="1">MEFFDLMKTAASEANLDLSEEQYEKFIKYMRLLQEWNEKINLTAITEDEEIIKKHFIDCIKAFKSEPIRNAKTIIDVGTGAGFPGLPIAIMNSNIKVTLLDSLNKRINFLNTVVNELGLENVTTIHSRAEDGARKTELRENFDVATSRAVANMAVLSEFCIPYVKKGGYFIALKGPLIDDELKDGDKAIRTLGGELKDIIEVKIEGTDLRHNIVEIKKIKQCSKIYPRKAGTVNKKPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH15</accession>
    <name>A0A386PH15_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04870</name>
        <name evidence="3" type="ORF">EI377_15385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33852">
        <property type="protein sequence ID" value="AYE33852"/>
        <property type="gene ID" value="CP523_04870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61998">
        <property type="protein sequence ID" value="QAS61998"/>
        <property type="gene ID" value="EI377_15385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="6971" checksum="B1277D19E6298ADB" modified="2018-12-05" version="1">MLLCEFMGKFMFVSAFCIGLFILSDILMMSILSNIEITLLVVSIIFVIIYAKTGNRFEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH52</accession>
    <name>A0A386PH52_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 10">Thymidine kinase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tdk</name>
        <name evidence="12" type="ORF">CP523_10105</name>
        <name evidence="13" type="ORF">EI377_04905</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 11">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676593.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00350"/>
    <dbReference type="EnsemblBacteria" id="AYE34727">
        <property type="protein sequence ID" value="AYE34727"/>
        <property type="gene ID" value="CP523_10105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60128">
        <property type="protein sequence ID" value="QAS60128"/>
        <property type="gene ID" value="EI377_04905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="195" mass="22349" checksum="8113519B387E5AE1" modified="2018-12-05" version="1">MSKLYFRYGAMNSGKSTHLMQVAHNYEERGMKVALVKPSTDKKGGEKLLSRLGVERKVDLIIGENDNIIEEVKKYKNKVNGIDCILVDEVQFLKAKQIDELFEVAVVLDIPVICYGLRTDFKMQGFEGSTRLLLIAHSIEEMKTICKCGRKALFNGRKINNKFVFEGEQIAIDHIDNVEYESLCGNCYFKYQHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH92</accession>
    <name>A0A386PH92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05295</name>
        <name evidence="3" type="ORF">EI377_15855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33932">
        <property type="protein sequence ID" value="AYE33932"/>
        <property type="gene ID" value="CP523_05295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62083">
        <property type="protein sequence ID" value="QAS62083"/>
        <property type="gene ID" value="EI377_15855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="246" mass="28350" checksum="761CBDF9B0FC5A3D" modified="2018-12-05" version="1">MVVLFMKTKNFFKNFFYILKYIFILYLVNITVGILQYVTDIKNNDLGVFIALISTLFIYYILLKKEKKNLFRYVKINKIKITSRSILLILIFSISYFCIYTSLNNISLKTSQGTEILHANLNILAIFHLILLAPLIEEILFRGIIFLKLKESVNVYTAIIVQGLIFGFLHGAVSGYIAQSLLATLSGIVFCYIYYKTDNLTFPIILHIIYNLLVLIFQTLMTNTNIVILLSIGIIGLTLSYFLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH2</accession>
    <name>A0A386PHH2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Toxin PIN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14380</name>
        <name evidence="7" type="ORF">EI377_09345</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676801.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02466"/>
    <dbReference type="EnsemblBacteria" id="AYE35523">
        <property type="protein sequence ID" value="AYE35523"/>
        <property type="gene ID" value="CP523_14380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60909">
        <property type="protein sequence ID" value="QAS60909"/>
        <property type="gene ID" value="EI377_09345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="11"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="401" mass="43726" checksum="70095D5CB910ADAD" modified="2018-12-05" version="1">MTIIIIILSLIFIGILSSLSGQIIEKIKLPSLIGMMISGMILGPSFLNIIPKEVINISPAIKDIALVTVLFIGGLGISLNQMKEIGRPAILLSIIPATLEGITIALLSRYFLNFTFIQGAILGFIIAAVSPAVLVPSMISLINRKLGENKSIPQMLLVGASADDTIAITLFTTFLGVYLQGINGKNISIVKQLSFIPITIILSILIGWILAKLTSYIFKNISKSFIKVLIAYFICIIMRVIEQNFKIEIFNSLLTIMIYGFFLRNYVEEISKEILNIMNKIWAIGKIYLFTFVGMAINPKLVGNFFIIGVIMLIFSLSIRSLGVLISLIGTNLNKKEKLFCIIAYLPKATVQSAKAGIPLQMGVLGGDVMQAIAILSVLITAPIGAIGIKLTAEKYLEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL2</accession>
    <name>A0A386PHL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydropyrimidine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14790</name>
        <name evidence="4" type="ORF">EI377_09750</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676117.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01325"/>
    <dbReference type="EnsemblBacteria" id="AYE35595">
        <property type="protein sequence ID" value="AYE35595"/>
        <property type="gene ID" value="CP523_14790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60981">
        <property type="protein sequence ID" value="QAS60981"/>
        <property type="gene ID" value="EI377_09750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="118"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="417" mass="45532" checksum="9C2D8B4765B7831D" modified="2018-12-05" version="1">MSEKMLTPYFAIEESARCLLCHDAPCSKACPVGTDPAKFIRSLRFRNLKGAVETIRENNVLGGICARVCPTAKYCEGACSRSGIDRPIEIAKIQRYLTDYEKVLGLQILEKVNLNKEKVAIIGSGPSGLGAATKLVSLGYNVTVFEEKDKLGGWLTYGIPEERLPKEVIENEISYIRNLGVEFKTNCKIGRDKTIEQLKKEGFKAILVSVGMQKNRKVDIIGANLEGVINGTDLLSEVKVLNKNRLGNKVIVIGGGDVAIDCATTANILGCDVKLVYRRTIDKMPADRASVEYLQSLNIPIFTGFKPKEIIGKGNKVERFKAVGMFDDSVIELPADNVIFAIGQEPTNVDSIANLNISDSGVIVTQDYKTNIEGIFASGDITEGDKTVVFALKEGKEAAKAIDNYLRKADSRKEGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN1</accession>
    <name>A0A386PHN1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14900</name>
        <name evidence="4" type="ORF">EI377_09855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676078.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01303"/>
    <dbReference type="EnsemblBacteria" id="AYE35615">
        <property type="protein sequence ID" value="AYE35615"/>
        <property type="gene ID" value="CP523_14900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61002">
        <property type="protein sequence ID" value="QAS61002"/>
        <property type="gene ID" value="EI377_09855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="243" mass="27875" checksum="C86D8DA9CCDB5041" modified="2018-12-05" version="1">MKRLTGKALIFLGSIVLGFFIVNSMDLNNKQSMIQLNAVEYKKAIDEKNQLYKEVEALKEENIKNQEKINNYSHDDERQEKIFEDMKNQVKDYGRLVGVSEVKGPGVVLKITDGNIDLKQDTQFETWRKILHDSDMALVLNEARKAGGEAMAVNKHRVLPLTGVICNWAFIGFNDDSLEQAPFYIYIIGEPEQIKTALLSEDSHIKKLILRELKVEIEVRDEIVIPGAIQNLETKYMKRYEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP6</accession>
    <name>A0A386PHP6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13285</name>
        <name evidence="3" type="ORF">EI377_08145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35320">
        <property type="protein sequence ID" value="AYE35320"/>
        <property type="gene ID" value="CP523_13285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60708">
        <property type="protein sequence ID" value="QAS60708"/>
        <property type="gene ID" value="EI377_08145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007119">
        <property type="entry name" value="Phage_minor_struct_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010572">
        <property type="entry name" value="Prophage_Tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06605">
        <property type="entry name" value="Prophage_tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01665">
        <property type="entry name" value="put_anti_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prophage_tail" evidence="1">
        <location>
            <begin position="118"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="469" mass="53517" checksum="546810C8A2E99B36" modified="2018-12-05" version="1">MYEIKLINENEETIINSISTSVEAPRLSSFNIKHGINVIDTLTFDISPNNPGYFKIIALKTLIEVLNKKLNKVEFRGRILLPTEKMNNNGVLTKSVVCESELGYLMDSSTTYGEYHNISVKNFLKVIIDNHNNQVSEDKKFVLGNVTVKNNNDRLYRYLGYVKTFQSIKDKLIDRLGGELQIRYENGTRYLDYLESIGEFKETEIRISKNLKSIEQQKDPTSIISRLIPLGSKLENSEERLTIESVNGGIKYIDDIDAMKKFGVIVGVKLWDDVTRASNLLKNGQDYLKRNNKIKKKYKITALDLSLIGLDLNSFEVYNTYNVINPLMNINEELRVIEKNIDGNNPQNSSLTVGDKFEDIKQYQLGIIKANKNIETLNENINSTIDVVKTISTESKNTAKVLNKTNEVLTNTNQTVKDLTDAIIEINNRLNDNVKETQNLINATSDIKDNFNNVNNKLEKLKRRAIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ6</accession>
    <name>A0A386PHQ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF881 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14890</name>
        <name evidence="4" type="ORF">EI377_09845</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676085.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01305"/>
    <dbReference type="EnsemblBacteria" id="AYE35613">
        <property type="protein sequence ID" value="AYE35613"/>
        <property type="gene ID" value="CP523_14890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61000">
        <property type="protein sequence ID" value="QAS61000"/>
        <property type="gene ID" value="EI377_09845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="239" mass="26464" checksum="07CD0A6BAEA5F677" modified="2018-12-05" version="1">MRKANSQIVVAIVCALLGFLLAHQFKLLIKKDQINSNVKNSNIVAEIDSLKKEKEELVKSNSTLSEQLKTLEEAAAKKGEVEGEIKKQLDNTRMHLGLVDVKGPGIVITITPKTNIFGSNANETKRDISEEELVHIVNLLWYSRAEAISINDFRITPQTGIKNSGNYIWIGSAGKVDPKDKIVIKAIGEKEKLNVGMTFPGSLDYGALQNYNTEVKNSDDIIINKTTQSLKSEFIKPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU1</accession>
    <name>A0A386PHU1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04255</name>
        <name evidence="3" type="ORF">EI377_14780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676495.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00426"/>
    <dbReference type="EnsemblBacteria" id="AYE33739">
        <property type="protein sequence ID" value="AYE33739"/>
        <property type="gene ID" value="CP523_04255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61896">
        <property type="protein sequence ID" value="QAS61896"/>
        <property type="gene ID" value="EI377_14780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="496" mass="56227" checksum="EF7B13714A6C965B" modified="2018-12-05" version="1">MKKQVKYLGLIVLSIIAFLLLFKFVNNNKPFSEGDQKFTIRKYNLQQQGFKGLEEIFRTHTELSSILLIDTFDGDISKDGTLGNFNIVLSGYNNSKEYLQSYRFIYNSKKKILNYAGPKSNIKSTLPQIYNENNEISFLDTQLKMIPIKEQIEKLDFPSYSIGYNSNTKPLEGEPIVNINNNDKFPTFTFDEYKSGKYGKSNGHTSVIFSLYSGSSLALSENKIMYNCIPANSESLSGNKNNFMKKDYYINGYKIKITRDYGETWIDIPISEENLSSTLEFYRLGIEIPPDSYYISDNPGGIIALLYGESPTLLLSKNDGNNWNNIKLDINLEKPITRRIIGFTDEINGYLALGTDWSMGSGEAKILCLTDDGGLTWNQKELPLSNTSSTLTGITFLDNTIGVLSLDSGMDEKFPKLFISNNKGDSWNELNLPLDKITEDVSYLSKVDSLTYENGMYKLVLGQDLNNNKKVVFESKDLSNDWIFKESYEAVIHYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU7</accession>
    <name>A0A386PHU7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">CP523_11220</name>
        <name evidence="8" type="ORF">EI377_06010</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677038.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00896"/>
    <dbReference type="EnsemblBacteria" id="AYE34937">
        <property type="protein sequence ID" value="AYE34937"/>
        <property type="gene ID" value="CP523_11220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60331">
        <property type="protein sequence ID" value="QAS60331"/>
        <property type="gene ID" value="EI377_06010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11220"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="23429" checksum="BF3940551AC9240F" modified="2018-12-05" version="1">MNTGLIVSCQALDNEPLHSSFIMSKMALAAKEGGAVGIRANTVEDIKAIKNEVDLPIIGIIKKDYEGMISYITPTIKEVEELVNSKVDVIAVDATINQDLEFLKSLKRLYPNQKFMADISTVEEGIRAAEIGFDYVGTTLVGYTEQSKGVNNFEVLEKLIKECKKPVIAEGNFDTPEKARKAMEMGAFAVVVGGAITRPQLITKKFAEEVKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI57</accession>
    <name>A0A386PI57_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14205</name>
        <name evidence="2" type="ORF">EI377_09110</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678508.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00281"/>
    <dbReference type="EnsemblBacteria" id="AYE35490">
        <property type="protein sequence ID" value="AYE35490"/>
        <property type="gene ID" value="CP523_14205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60876">
        <property type="protein sequence ID" value="QAS60876"/>
        <property type="gene ID" value="EI377_09110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="284" mass="32552" checksum="F091BAB6B8C2D76F" modified="2018-12-05" version="1">MRKFWESIYSPNYITGYNPFILKDMNKAIERMVEAINNRKKIVIYGVPNVDGLCAIASLSLVLRYLNADVEYIINDDDSNTSGITSNDIINNVNFLGGQLLITLGIDLNSEEEQMLCKDLGIDLIVLENKLINIDKGYIYINPNQKCCQYRYKNLSISGLAFKLMQAIAIYYNIKSINKYLDLILIGEQWAEVPLKGENAVILKEGRKFLINTNNHGLRSIMDYYDIIEMDEKCILKIIEVITPTINAVRMMDNARIIIELLTTTKKERAEQITKYLNKSKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID4</accession>
    <name>A0A386PID4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_10735</name>
        <name evidence="8" type="ORF">EI377_05520</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674117.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01355"/>
    <dbReference type="EnsemblBacteria" id="AYE34841">
        <property type="protein sequence ID" value="AYE34841"/>
        <property type="gene ID" value="CP523_10735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60235">
        <property type="protein sequence ID" value="QAS60235"/>
        <property type="gene ID" value="EI377_05520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="34459" checksum="BB5D439DA65D9B5A" modified="2018-12-05" version="1">MAEVRVKKSRFDRKLDKIRQLEEAGELGKKKVNRSLRKLMNNKLAVIGIVIFAIILLSAIFAPVLTKYDPLQVDMANVLQKPSSEHWFGTDKVGRDVFSRVLYGGRISILIGLGSALGCAFFGVLLGCYGGYKGGWFDRIVLRISEVFMSFPQLVLVLMLVSILGQSLTNLIIIFILTGWGSVYRMARAKILSIREEEYVQSLKSFGLNDFLICYKHMLPNAIGPIVVNITLSTAMFILEEASLSFLGLGVPLEIATWGNILNASQDMFTLQNNWWLWLPVGIVISLFVMSINFVGDGLRDTTDPTQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH8</accession>
    <name>A0A386PIH8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SdpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08275</name>
        <name evidence="3" type="ORF">EI377_03025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674734.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34422">
        <property type="protein sequence ID" value="AYE34422"/>
        <property type="gene ID" value="CP523_08275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59827">
        <property type="protein sequence ID" value="QAS59827"/>
        <property type="gene ID" value="EI377_03025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="13193" checksum="06F5F2EB54F047B5" modified="2018-12-05" version="1">MNLWIALLIIEIIPILMWIVGGVCENKALNFKNQGIGYRSKFSGKNKYTWEYANKMVAKVAGGVGTLLFIINAIIIMMFGLATLIILLAINLLCGFLAILIVEKSLKKKFDSSGKIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK4</accession>
    <name>A0A386PIK4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">tsaD</name>
        <name evidence="8" type="ORF">CP523_09945</name>
        <name evidence="9" type="ORF">EI377_04730</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676546.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00318"/>
    <dbReference type="EnsemblBacteria" id="AYE34698">
        <property type="protein sequence ID" value="AYE34698"/>
        <property type="gene ID" value="CP523_09945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60099">
        <property type="protein sequence ID" value="QAS60099"/>
        <property type="gene ID" value="EI377_04730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="336" mass="35981" checksum="49F52D0BF2333523" modified="2018-12-05" version="1">MDKKLILSIESSCDETSAAVIKDGREVLSNIIATQIDTHMKYGGVVPEVASRMHIEVINGVVMEALEKAGVTLDDIDAIGVTYGPGLVGALLVGLQYAKGLAFASKKPLVGVNHIEGHISANYIQHKDLEPPFVSLVVSGGHTFIVHVKNYGEYEVIGQTRDDAAGEAYDKVARALGLGYPGGPKIDKLAKEGNENAIEFPKANFHEETLDFSFSGVKSSVLNYINKCKMQNIEFNKADVAASFQKAVIDVLKDNVIKTCKKKKVDKIAIAGGVASNSSLRKELIEAAGKLGIQVLFPEPILCTDNAAMIGSAAYFNLTNGKISPLNLNAKPNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM2</accession>
    <name>A0A386PIM2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11305</name>
        <name evidence="4" type="ORF">EI377_06125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02818"/>
    <dbReference type="EnsemblBacteria" id="AYE34951">
        <property type="protein sequence ID" value="AYE34951"/>
        <property type="gene ID" value="CP523_11305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60346">
        <property type="protein sequence ID" value="QAS60346"/>
        <property type="gene ID" value="EI377_06125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="223" mass="26259" checksum="F4F83E863113C3CD" modified="2018-12-05" version="1">MKKTIINHLHICSLVYCGNTNLAIKLFNKNLKNLISTTGFEYCKTFIYSLNFSIYNYILVKEGVSLHKCCFKNTIENYDYSDVNSIIEIGHKIINSYSYCKDYLSEKYSHPEIKKAICYIHKHIDENISLNDICSIVNMNKTYFCRVFKTYTNYTFSEYVNRAKINAAKHLLLDPQLSLVDVSFYCGFNNYTYFCKLFKKIVGMNPLKYRNLRNKTEILDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP4</accession>
    <name>A0A386PIP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35700">
        <property type="protein sequence ID" value="AYE35700"/>
        <property type="gene ID" value="CP523_15370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="125" mass="14270" checksum="74683E441C8BCA1F" modified="2018-12-05" version="1">MKISNEKIVNSIGVLSKVTGMDLNIKVSYAIAKNISKIEKELEIYNKEKGKLIDKYAFKDEEGKIKSNKDGAVDIDDIENWNKDIKELLEIENDIDIHLIEIEDLSKCSCNITPGELMLISYMFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP7</accession>
    <name>A0A386PIP7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11465</name>
        <name evidence="2" type="ORF">EI377_06280</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673298.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34981">
        <property type="protein sequence ID" value="AYE34981"/>
        <property type="gene ID" value="CP523_11465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60374">
        <property type="protein sequence ID" value="QAS60374"/>
        <property type="gene ID" value="EI377_06280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="352" mass="37461" checksum="7F1EE9007DAEB6BB" modified="2018-12-05" version="1">MITKCSGENLMNLQCVNNNKANELKSKNTLKADTSSEVNKYKEDVINNISINNKKEDKDTSKSVAGTISSIGGKLSRVGSAIGRFANSVVNNVKKTFVTVSENVKNTVSKISTKIKDTFNEVTEKTMKLAKSVEAKITDTAEKISATVKQVTATAAQLKDVMLEVKDSATSLVTTGVKTAVKIGAEVGKVVTKVGLSVANIKRVMADPSVGIIGKVSNTVSSIGTGFYAIKEGVENISGTVKDAYKSMASDYKKTVEGVELSIKLCKETANTIVTCGKEVAENVKTIVSDVKTTASELKTTLVNAKDEISDSLSKGINNSVSAIKEGYANIKNDYNEADEVLRNEMGTPVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX2</accession>
    <name>A0A386PIX2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_13585</name>
        <name evidence="6" type="ORF">EI377_08480</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679032.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00089"/>
    <dbReference type="EnsemblBacteria" id="AYE35377">
        <property type="protein sequence ID" value="AYE35377"/>
        <property type="gene ID" value="CP523_13585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60767">
        <property type="protein sequence ID" value="QAS60767"/>
        <property type="gene ID" value="EI377_08480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="29376" checksum="65D9F2259F1515BF" modified="2018-12-05" version="1">MCNLNDKVIEIKDLKMSYGNKEVLKGINLEIRKGNIIGYIGPNGAGKSTTVKIILGLVKGFTGEVKVFGQDISNGDESYKKKIGYVPEVPEIYDSLTGKEYLTFIGQLYGFNYYDVNRKAKKLMRVLGIEEVYNKRISSYSKGMKQKLIIISSLLHNPDILFLDEPLSGLDANSVMIIKEILAELSRKGKTIFYSSHIMEVVEKISDRIVLINNGNIVADGAFDELQNSCKEGTLEEIFNELTGFNDHKELAENFISIVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ18</accession>
    <name>A0A386PJ18_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="6" type="ORF">CP523_13000</name>
        <name evidence="7" type="ORF">EI377_07875</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677881.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02540"/>
    <dbReference type="EnsemblBacteria" id="AYE35870">
        <property type="protein sequence ID" value="AYE35870"/>
        <property type="gene ID" value="CP523_13000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62180">
        <property type="protein sequence ID" value="QAS62180"/>
        <property type="gene ID" value="EI377_07875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13000"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="251"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="497" mass="55812" checksum="80BAE7D69AC31BA1" modified="2018-12-05" version="1">MNMNKIMFLGTASSVGKSTVATAFCRYFKNQGLKVAPFKALNISLNSYVTKDGLEMGRAQVVQAEACELEPVAYMNPILLKPSGNMKTQVIVNGRVYCNMDSYKYKELNKKLKGFVKETFFNFSKDYDLMVLEGSGSCAEINLRESDIANMTMAKVSDSDVILVADIDRGGVFASVVGTIMLLEEEERKRVKGVIINKFRGNVEYFKPAMKQLEDIINIPVLGALPYFQLDIEDEDSVTERIKNKVTNDIDIVVIRLPYMSNFTDFNALERLKGVSVRYVKEASDIKSPDILIIPGSKNTISDLRHIKENGIFNSICNLKGKDTLIFGICGGYQMLGKSINDIYGVEGNVTSEKGFGFLDMDTTFNKEKETKQTKGKANLGFLGLGKEVKVSGYEIHNGESNIGENSNPFIIGEDDKILGICNKDMNVFGTYLHGVFDEGRFSEELINNIKRKKGITSFNEETLDYKEYKLKEYDKLAKILEENIDMEKIKNIIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG5</accession>
    <name>A0A386PJG5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_07670</name>
        <name evidence="16" type="ORF">EI377_02360</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673865.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01143"/>
    <dbReference type="EnsemblBacteria" id="AYE34329">
        <property type="protein sequence ID" value="AYE34329"/>
        <property type="gene ID" value="CP523_07670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59725">
        <property type="protein sequence ID" value="QAS59725"/>
        <property type="gene ID" value="EI377_02360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 11 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="128"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS59725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="366" mass="41193" checksum="84CE127395369862" modified="2018-12-05" version="1">MIFICEKQKLQEAISIVTKAITGKTTMPILEGIYINANKDGLTLIGSDMDVSIETKLPADVLEIGKIVIDARIFSEIIRKLPNSEVKIETLENNIIQITCEKSVFNLVYMDGEDYPLLPSINENLTVEVPQNILKNMIKGTAFAIAQDETRPILQGILFEVKNKTLNLVALDGYRLAVKNEFLDNDNEIEVVIPGKTLNEVSKILEDISDIVRITFTNNHILFNLNETKVISRLLDGKYVNYESLLPQEYKILINVDKQELQSCIERASLMAKDGNSNLIKLDVQEDILVITSNSQLGKVREEVSINMQGGDIQIAFNSRYLLDVLKNMEDDEVVMQMTSSVSPCVIKGKNMENAKYLVLPVRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG7</accession>
    <name>A0A386PJG7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CP523_13680</name>
        <name evidence="15" type="ORF">EI377_08570</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677177.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02086"/>
    <dbReference type="EnsemblBacteria" id="AYE35394">
        <property type="protein sequence ID" value="AYE35394"/>
        <property type="gene ID" value="CP523_13680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60783">
        <property type="protein sequence ID" value="QAS60783"/>
        <property type="gene ID" value="EI377_08570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="307"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS60783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="402" mass="46116" checksum="6FCC2CF23C866E3C" modified="2018-12-05" version="1">MSKIKMITPLVEMDGDEMTRVLWDMIKEELLNPFIDLKTEYYDLGLEYRNKTNDKVTIDAANAIRKYGVGVKCATITPNSERVKEYNLKEMWKSPNGTIRAILDGTVFRTPIIIDSIKPYVRTWKKPITIARHAYGDIYKDVEMRIEGKGKVELVLTRENGQEERNLIHDFKKNGVVLGMHNINDSIESFARSCFNFALDSKQDLWFAAKDTISKKYDHTFKDIFEEIYNNEYKLAFEECGIEYFYTLIDDAIARVIKSEGGFIWACKNYDGDVMSDMIATAFGSLAMMTSVLVSKDGIYEYEAAHGTVQRHYYKHIKGEETSTNSIATIFAWSGALRKRGELDELDELVNFANKLEEASLKTINNGIMTKDLDLLSEIENKKIVNSYEFIKAIKSKLEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP9</accession>
    <name>A0A386PJP9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15510</name>
        <name evidence="2" type="ORF">EI377_10215</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00180"/>
    <dbReference type="EnsemblBacteria" id="AYE35727">
        <property type="protein sequence ID" value="AYE35727"/>
        <property type="gene ID" value="CP523_15510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61066">
        <property type="protein sequence ID" value="QAS61066"/>
        <property type="gene ID" value="EI377_10215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="182" mass="21999" checksum="A2754AEC898013B7" modified="2018-12-05" version="1">MKDITECMLPISEESFKGYIDIRFKNILQGFEEYKNSILINKFEDNYNNIENRFIGFMEAAFEINKSENADIPLIIDFYLSNLDEKAYFNLYNSLDEDDIETLERIKLNFKTKTNYFIILDKSLIPFFTRLSTRELFFITFYYRSFPTTIWGNYGFKFPVFYEDDNIFRKYKKLAENNKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR2</accession>
    <name>A0A386PJR2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14060</name>
        <name evidence="8" type="ORF">EI377_08965</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03088"/>
    <dbReference type="EnsemblBacteria" id="AYE35461">
        <property type="protein sequence ID" value="AYE35461"/>
        <property type="gene ID" value="CP523_14060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60849">
        <property type="protein sequence ID" value="QAS60849"/>
        <property type="gene ID" value="EI377_08965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010162">
        <property type="entry name" value="PepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF2">
        <property type="entry name" value="PTHR42994:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01883">
        <property type="entry name" value="PepT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="6">
        <location>
            <begin position="183"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="368" mass="39829" checksum="579C2EA6C2CBEDF4" modified="2018-12-05" version="1">MINRDRVVKRFLEYVQIDSESYKEGAFAKRLAKDLEKLGLEVEFDKACEVVKSDTGNLIAKLKGNVEGEPILFACHMDTVTPCTNIKPIIKDDIIYSDGTTVLGGDDKGGIAAIIEALTVIKENNIKHPNIEIVFTVAEEVGIYGAKNLDYSKIESKNAFIFDTSGDIGTIVIKGPAQDKLLVKITGKSAHAGVSPEDGISAIQIASEAISNMKLLRIDENTTANIGKINGGVATNIVCPEVIIEAETRSTVIESLEKQTAHMIETFEKAAEKFGGKVEITVNRLFGQFVINEDDEIVIKAKNALKAIGIEGKTKSTGGGSDTNVFNGNGLKAVNLSSGERKPHTLEEHMKIEDLEILSRLIVELSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU3</accession>
    <name>A0A386PJU3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11195</name>
        <name evidence="2" type="ORF">EI377_05985</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00901"/>
    <dbReference type="EnsemblBacteria" id="AYE34932">
        <property type="protein sequence ID" value="AYE34932"/>
        <property type="gene ID" value="CP523_11195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60326">
        <property type="protein sequence ID" value="QAS60326"/>
        <property type="gene ID" value="EI377_05985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="30127" checksum="53E64A37C8EB8C3A" modified="2018-12-05" version="1">MKDSDFKKVSDNPLYIRYIDNPKDELIFEALKKNGAAIKYIKNPSFDMKKLAIKNNPMAIEYISEIEEELAILSVKYLWNSLKYIKNPSDNVIKEAIFMKGWAIQFVDNPSKEIQLLAVKRDFDAIKYIKNPSEEVQLAAIENYWGAIRFIEKPTLSARREAVKRDEEAINYISYTLDELKILISENINIVKYVYDSIDVDMVIDVLIGKINTDEVNEKYIRDFLELEILEMDKVNFIREYGSKRAKILLVDYKLANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX4</accession>
    <name>A0A386PJX4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADP-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_08805</name>
        <name evidence="7" type="ORF">EI377_03565</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678091.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02702"/>
    <dbReference type="EnsemblBacteria" id="AYE34509">
        <property type="protein sequence ID" value="AYE34509"/>
        <property type="gene ID" value="CP523_08805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59912">
        <property type="protein sequence ID" value="QAS59912"/>
        <property type="gene ID" value="EI377_03565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="5">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="487" mass="53727" checksum="5EED9FE0B9EB0DB7" modified="2018-12-05" version="1">MFSCIKDKERTFRNLINGEWVNNKECKFIEIYSPINKELVGRVPAMTKEEVDFAIKSAKEAQKKWKDITVNERADILYRASDILEERKDELIDILVKEIAKDRKSAESEILRTADYIRFTADTAKNVSGESIPGDSFPGFKRNKISVVTREPLGVVLAISPFNYPINLAASKLAPALVAGNSVVLKPATQGSLCGLYLAKVFEQAGIPAGVLNTITGRGSEIGDYIVTHPEIDFINFTGSTEIGTRISRITTMVPLLMELGGKDAAIVLEDADLELAASNIVAGGYSYSGQRCTAVKRILVMDKVADKLVEKLKEKIDKLKVGNPLDSDVDIVPLIDTKAADFVWDLIEDAREKGAYLVSGGTREGNLIYPTLFDHVTTDMRLAWEEPFGPVLPIIRVKDKDMAIEIANKSEYGLQSSVFTENINEAFYVANRLEVGTVQVNNKTERGPDHFPFLGVKASGIGTQGIRYSIESMSRPKATVINLIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK02</accession>
    <name>A0A386PK02_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13165</name>
        <name evidence="2" type="ORF">EI377_08010</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35298">
        <property type="protein sequence ID" value="AYE35298"/>
        <property type="gene ID" value="CP523_13165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60687">
        <property type="protein sequence ID" value="QAS60687"/>
        <property type="gene ID" value="EI377_08010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="85" mass="10076" checksum="CE3ACCBB16697DE0" modified="2018-12-05" version="1">MKVNMGDYLIETDERQFIVKVKKIVEDSKLTKKENLGKEYWQPIAYCTSFESALKFVPQQVLRSNHDILVIKDKLEQIENFIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK77</accession>
    <name>A0A386PK77_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage portal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03107"/>
    <dbReference type="EnsemblBacteria" id="AYE35684">
        <property type="protein sequence ID" value="AYE35684"/>
        <property type="gene ID" value="CP523_15290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021145">
        <property type="entry name" value="Portal_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006428">
        <property type="entry name" value="Portal_SPP1-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05133">
        <property type="entry name" value="Phage_prot_Gp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01538">
        <property type="entry name" value="portal_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="463" mass="53003" checksum="9B13CBE319C5A49A" modified="2018-12-05" version="1">MTIYKDRELVNEDGTIPEKLLIKCLEEHNLQKIRYLELLDYYEGKHKILNRVMSNEDLPNNKLVCNHASYITDMAVGYVFGVPISYSGEGNGDELLNQIFTEIDEDSHNNELALDISILGIGNELIYMNDEDIPGIELAVLSPLNTFVVFDTTVKHKPIFAVNYTEKQDIEGTVKGLDVNVYTKYKLYRYFTANTSFNGLNLIDENEHYFDDIPIIEYKNNKTSTGDFETVLTLIDAYNTLQSDRINDKAQLADALLAVIGASLGDDETEQTNTAKLIKEMKILELDEGGDAKYLTKQLNETEVEVLKKSIKDDIHEFSKVPCLTDENFVGNSSGVAMKYKLLGFEQLAKTKERYFKKGLRQRIKLIANLEGTRAKIIDSNKIDIVMKRSLPVDDELKVRILQETEGSLSWETRIKEYNPEIDTEEEKKRLYEENQKKIEQQQKAFGSYDIKSTEKDGEVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKC2</accession>
    <name>A0A386PKC2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_09900</name>
        <name evidence="12" type="ORF">EI377_04685</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676525.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00309"/>
    <dbReference type="EnsemblBacteria" id="AYE34689">
        <property type="protein sequence ID" value="AYE34689"/>
        <property type="gene ID" value="CP523_09900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60090">
        <property type="protein sequence ID" value="QAS60090"/>
        <property type="gene ID" value="EI377_04685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="26392" checksum="804F0EDAD3B7BF6B" modified="2018-12-05" version="1">MGKVLLVEDEASIRGFLKINLKRNDLKVLETDNGEDGLKIADLERPEIAILDVMLPGIDGFEVCDTLRRKYPNMGIIMLTAKSQDIDKIMGLEYGADDYIVKPFNPIEVVLRVKALLRRIVEKQNKREKLIVGNFTIDLYSQKLLKQEEEIDLTPKEYLLMKLFLENPNRAFKRDELLDLVWGENYFGDPKIIDVNIRRLRAKIEDDSYEPKYIETVWGIGYRWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE8</accession>
    <name>A0A386PKE8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13810</name>
        <name evidence="2" type="ORF">EI377_08705</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677134.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35418">
        <property type="protein sequence ID" value="AYE35418"/>
        <property type="gene ID" value="CP523_13810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60806">
        <property type="protein sequence ID" value="QAS60806"/>
        <property type="gene ID" value="EI377_08705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="18053" checksum="DB142C9C5CE5102A" modified="2018-12-05" version="1">MLLQERIEELNSGILKIKNDKVHIIGFLSQERLEDYYYRNMQCFFSNGIYDYEDLDFSRIKDNSLFLVLKDDKLINKYLYKLLLKNTFKYKTKDNKIVTKTFKIRKSEYSEQYNLVIDKKNLSFSTIDSIQSYLKNNYTYNLNIEELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKG8</accession>
    <name>A0A386PKG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15740</name>
        <name evidence="2" type="ORF">EI377_10455</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678908.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35771">
        <property type="protein sequence ID" value="AYE35771"/>
        <property type="gene ID" value="CP523_15740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61109">
        <property type="protein sequence ID" value="QAS61109"/>
        <property type="gene ID" value="EI377_10455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="111" mass="13141" checksum="648E492EE234C8B7" modified="2018-12-05" version="1">MKEAKEHIAKISKASAYFIFRNGPIKEMYKEGKVSDEDIKTIQCYLQDHLAYLYEVLLEENNINKFQLIVDTMDKFYINDNEKIKIDDEGFENFYNQLFPSSTIKSNIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI0</accession>
    <name>A0A386PKI0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00200</name>
        <name evidence="3" type="ORF">EI377_10690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01192"/>
    <dbReference type="EnsemblBacteria" id="AYE35784">
        <property type="protein sequence ID" value="AYE35784"/>
        <property type="gene ID" value="CP523_00200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62204">
        <property type="protein sequence ID" value="QAS62204"/>
        <property type="gene ID" value="EI377_10690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025945">
        <property type="entry name" value="DHHW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14286">
        <property type="entry name" value="DHHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="370" mass="43933" checksum="B9F82F1EA15F0877" modified="2018-12-05" version="1">MKYPLFTFFTIIIVIFTFLDIVKPINFFSELENRSLSQKPKFTLYNLFYSDYINNYNNYINDQFIFRDLWIDLKSITEYLLGKRENNGIIYTKDGFMFQKQQNLNLDRLNKNILAIEDFVREIQSNSTLMLIPNSYTIYEEKLPIGLELIDEKKIISSIYSYFNKLSLNTLDVVTPLINNKKDYIYYKTDHHWTSYGAYIAYYTYVKSLNLTPVDINSLVNYSIPGFYGSYFSKAKLFNSQSDTITYFEDNNLEISIDGIAYKSLYDLNKFKERDKYSAFLRGNNGLTIIRNKDVNDNIKGKRVLVFKDSYANCFVNFLTYNFEEVYVIDLRSFNQKIKEFIKDKSFNEVLIMYNIVNLSEDVNIVKFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKJ1</accession>
    <name>A0A386PKJ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Anti-sigma F factor antagonist</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Stage II sporulation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">spoIIAA</name>
        <name evidence="7" type="ORF">CP523_02365</name>
        <name evidence="8" type="ORF">EI377_12885</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674084.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00494"/>
    <dbReference type="EnsemblBacteria" id="AYE35801">
        <property type="protein sequence ID" value="AYE35801"/>
        <property type="gene ID" value="CP523_02365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61558">
        <property type="protein sequence ID" value="QAS61558"/>
        <property type="gene ID" value="EI377_12885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045152">
        <property type="term" value="F:antisigma factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014237">
        <property type="entry name" value="Anti-sigma_F_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02886">
        <property type="entry name" value="spore_II_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="111" mass="12735" checksum="137C083C0CEB4D42" modified="2018-12-05" version="1">MYLKFDKNMDKLIISLMGELDHHSAEEVRVKIDDRIDRDNIKKVILNFNGVTFMDSSGIGVVIGRLKKMQNREGKLCVADVNRTVNRVFEISGMYKIIDSYCSVDEAMECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKK2</accession>
    <name>A0A386PKK2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13085</name>
        <name evidence="2" type="ORF">EI377_07955</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677841.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35282">
        <property type="protein sequence ID" value="AYE35282"/>
        <property type="gene ID" value="CP523_13085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60676">
        <property type="protein sequence ID" value="QAS60676"/>
        <property type="gene ID" value="EI377_07955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="90" mass="10418" checksum="AB80AA491597ADFE" modified="2018-12-05" version="1">MNNLEVGKKIAEIVDNISDCKTNLKLLEDSKSIKNPYVYVGDRFKSLIKIEADKNIILHMIEIEQKRLKDYEKKLNELLNVKATVLNICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKL7</accession>
    <name>A0A386PKL7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">CP523_14295</name>
        <name evidence="11" type="ORF">EI377_09205</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02448"/>
    <dbReference type="EnsemblBacteria" id="AYE35508">
        <property type="protein sequence ID" value="AYE35508"/>
        <property type="gene ID" value="CP523_14295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60893">
        <property type="protein sequence ID" value="QAS60893"/>
        <property type="gene ID" value="EI377_09205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14295"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="351"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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        <location>
            <position position="97"/>
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        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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            <position position="119"/>
        </location>
        <ligand>
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        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
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        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
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        <location>
            <position position="228"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
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        <source>
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            <dbReference type="HAMAP-Rule" id="MF_00051"/>
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            <dbReference type="PIRSR" id="PIRSR000412-50"/>
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            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE35508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="410" mass="45160" checksum="8A7C3D6B06455AC2" modified="2018-12-05" version="1">MNFNELLKDDELIYELVEKELDRQRNGIELIASENFASKAVMEAMGSYLTNKYAEGYPNKRYYGGCHIVDEVEEIARERVKKLFNAEHANVQPHSGSQANMAVYLSILEPGDTVLGMDLSHGGHLTHGSPVNFSGKLFNFVSYGVDKKTEVIDYDVVRKLALEHKPKLIVAGASAYSRIIDFKKFKEICDEVGALLMVDMAHIAGLIAAGLHPSPVPYADFVTSTTHKTLRGPRGGLILCKEKYAKQLDKNIFPGIQGGPLMHIIAAKAVCFKEALDPSYKTYMENVVDNCKALSDELIKHGFNIVSGGTDNHLILVDLTNKDITGKDAENVLDSIGITVNKNTVPNETRSPFVTSGIRIGTPAVTTRGFNAEDMKEIASIINDALSNTDIDVELLRNRVKGLCDKHSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP0</accession>
    <name>A0A386PKP0_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">Carbohydrate diacid regulator</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CP523_12775</name>
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    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF05651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="350" mass="41271" checksum="E9C145D51877A381" modified="2018-12-05" version="1">MLSKELAQNIVDKMMDVIPYNVNVMDYKGKIIGSGDYLRIGNLHEGAKKALEEKRLIEIYEKVENSRPGVNTPIVFRGEIIGVIGITGNPDEVRQFSKLVSVTAELLINQEYTLNQHMIRQRLKEEFIYEWIYLNEDYNSDFINRGKALGIDVNLERIVVVVENEREKFKELRRFVKDDEYYIKFSPNRIALILRNKKNIYFRIDSIKEFMDISITKVGVGTLHKKLIESLSEALQSLEIGKKLYKNDFVNIYDKIRLFYKGEKLFNIKECKSIIYRIESEGSDLNLLETFLCYMEMNGEKQKVANEIYIHRNTLNYRLEKIEEITGLHFNDYLEFFQLLLAYISYKLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Recombinase family protein</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">EI377_08690</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677138.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35416">
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        <property type="gene ID" value="CP523_13800"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60804"/>
        <property type="gene ID" value="EI377_08690"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:DNA strand exchange activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="167"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="450"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="537" mass="61881" checksum="AC9FF88FAD8720F2" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL96</accession>
    <name>A0A386PL96_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine/serine exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14285</name>
        <name evidence="4" type="ORF">EI377_09195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676769.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02446"/>
    <dbReference type="EnsemblBacteria" id="AYE35506">
        <property type="protein sequence ID" value="AYE35506"/>
        <property type="gene ID" value="CP523_14285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60892">
        <property type="protein sequence ID" value="QAS60892"/>
        <property type="gene ID" value="EI377_09195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="9"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="27764" checksum="F73B1D6F8565E22D" modified="2018-12-05" version="1">MDVNELLHVATFAGKIMLESGGETYRSEEIIWRICKIYGAEEAESFVTPTGIMVSVCHENKTFSLIRRVSTRTVDLNKVDKVNDLSRNILSRNLSVSDLKRELKLIDEGERYSLTTNVIISALGAFCFVFLFNGTFRDGIAAFFIGLVIKIISIKFSELNINPFFINSICAGITAIMAIIFFKIGLSKNIDTTIIGSIMLLVPGLAITNAIRDTISGDLLAGLTRAAEAFLVAISIAIGTGAVLSFWLNTFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLA1</accession>
    <name>A0A386PLA1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14345</name>
        <name evidence="3" type="ORF">EI377_09255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02459"/>
    <dbReference type="EnsemblBacteria" id="AYE35516">
        <property type="protein sequence ID" value="AYE35516"/>
        <property type="gene ID" value="CP523_14345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60901">
        <property type="protein sequence ID" value="QAS60901"/>
        <property type="gene ID" value="EI377_09255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="247" mass="26349" checksum="95208D72BCA5B84D" modified="2018-12-05" version="1">MINLQGKVALVTGASRGIGKEIALQLAKSGASVIVNYSKDDNGAELTLAEIIANGGYGKLSKGDISSFETCKNIIDDIIKNFGKIDIIINNAGISKIGLFMDSSCEEINNLIGINMLGAMYLSKFALPHMISKGQGNIINISSMWGEVGASCEVMYSTSKGGINLFTKSLAKEVAPMGIRVNAIAPGVIDTEMNSFLEDDDVRQLEEEIPAGRFGKTSEIAKAVLFLCNDECKYLTGQIIRIDGGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLI2</accession>
    <name>A0A386PLI2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage III sporulation protein AA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIIAA</name>
        <name evidence="4" type="ORF">CP523_15010</name>
        <name evidence="5" type="ORF">EI377_09965</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676040.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01282"/>
    <dbReference type="EnsemblBacteria" id="AYE35636">
        <property type="protein sequence ID" value="AYE35636"/>
        <property type="gene ID" value="CP523_15010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61023">
        <property type="protein sequence ID" value="QAS61023"/>
        <property type="gene ID" value="EI377_09965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014217">
        <property type="entry name" value="Spore_III_AA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02858">
        <property type="entry name" value="spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="137"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="34483" checksum="EEBB200EA13B8021" modified="2018-12-05" version="1">MTGEEEVFKVLPLKIGNILRDSTLKNSIQEIRIKIGKPVIVYTFKGEEVLSYVATTEDIKQTLVKISNYSLYAYEEEIKQGYITIRGGHRIGIAGECVFVSGTIRTIKNISSLNFRICREVKGCSNEVMRYITEKDRVFNTLIVSPPKCGKTTILRDIARNISSGMYIRDLKGKKVCIIDERSEIAGSFNGVPQMDVGIRSDVLDNCLKREGMIMAIRSLSPEVLICDEIGTKGDIEALQMAFNSGVNVVVTLHGYCIEDIYRRKVFKEMLECSILDRIIILSNRKGVGTLENIYEVGMEGNLKCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLL5</accession>
    <name>A0A386PLL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674082.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35802">
        <property type="protein sequence ID" value="AYE35802"/>
        <property type="gene ID" value="CP523_02415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="59" mass="5773" checksum="702C56E994472F0B" modified="2018-12-05" version="1">MFDKNGSVSPCLPCCNDCGCGCGGCGGCGGCGGCGGGFGNGFGGCGGWFWIILLLCFCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLM2</accession>
    <name>A0A386PLM2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0291 protein CP523_13495</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13495</name>
        <name evidence="3" type="ORF">EI377_08395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0291 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677580.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35359">
        <property type="protein sequence ID" value="AYE35359"/>
        <property type="gene ID" value="CP523_13495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60750">
        <property type="protein sequence ID" value="QAS60750"/>
        <property type="gene ID" value="EI377_08395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01103">
        <property type="entry name" value="UPF0291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009242">
        <property type="entry name" value="DUF896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37300">
        <property type="entry name" value="PTHR37300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05979">
        <property type="entry name" value="DUF896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="67" mass="8116" checksum="B51CD8E3B70F01E7" modified="2018-12-05" version="1">MDYNDMKIDDIIKRINELYKKSKEEGLNEEEKEEQQKLRRVYIDRVKSNFKVQLEGIEPKNPTSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM10</accession>
    <name>A0A386PM10_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LacI family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14740</name>
        <name evidence="3" type="ORF">EI377_09700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676156.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01336"/>
    <dbReference type="EnsemblBacteria" id="AYE35886">
        <property type="protein sequence ID" value="AYE35886"/>
        <property type="gene ID" value="CP523_14740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60972">
        <property type="protein sequence ID" value="QAS60972"/>
        <property type="gene ID" value="EI377_09700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="39"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="325" mass="36909" checksum="1EE2720C1B4807AE" modified="2018-12-05" version="1">MKKKKKQILIIIFLLLILSFLFLISELLISGEKREVYNISIIVRGGNSESWMIMKQGAEQAASEMNVNISFITLSNENNVKDQKDLIEREIISGADAIVISPVDYEEMREPIEEAMKKVPVVLIESTINTKKDIHYISCNNYELGENLAEELMKMGNTRSKIAIMGRNLNSSSIKDRYKGFTDAIKKSKNTYDLLDISGNEEVIYNEAKNIIENNLSDVIVTFDPDVLEIVGKVKRDFMYAKKRNIGIEIYGSGITSKGISFLEENIINSIAVQNDFNIGYLGIKTAVDEIKGNNVKNKTIYSTIINTRTMYSDENQRLLFPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMF9</accession>
    <name>A0A386PMF9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>unnamed1</name>
    </geneLocation>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
            <plasmid evidence="3">unnamed1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023672">
        <property type="protein sequence ID" value="AYE35899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35899">
        <property type="protein sequence ID" value="AYE35899"/>
        <property type="gene ID" value="CP523_15810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Plasmid unnamed1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017348834" evidence="1">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="106" mass="11728" checksum="4DB9DE1FEC0BD93F" modified="2018-12-05" version="1">MNTKLKKLTVCALTLATFSSSTVSTFAWFWNKVDASDHWVTKTSYGSAYASGFTTSDKEHYTNVQLYAGNQMRESGRVWGSGQVDASTDSAPYVENQTHSAVFYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB65</accession>
    <name>A0A386PB65_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00195</name>
        <name evidence="2" type="ORF">EI377_10695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677389.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01193"/>
    <dbReference type="EnsemblBacteria" id="AYE32980">
        <property type="protein sequence ID" value="AYE32980"/>
        <property type="gene ID" value="CP523_00195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61152">
        <property type="protein sequence ID" value="QAS61152"/>
        <property type="gene ID" value="EI377_10695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="7130" checksum="200BD4ECA947C035" modified="2018-12-05" version="1">MELNIFIKGKKEPLIYIGDRIDLLDFILNGVKYKQIRVFKNGFSKSELIKSSLINKTQEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBF4</accession>
    <name>A0A386PBF4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridylate kinase</fullName>
            <shortName evidence="10">UK</shortName>
            <ecNumber evidence="10">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Uridine monophosphate kinase</fullName>
            <shortName evidence="10">UMP kinase</shortName>
            <shortName evidence="10">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pyrH</name>
        <name evidence="12" type="ORF">CP523_00735</name>
        <name evidence="13" type="ORF">EI377_11230</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674642.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02373"/>
    <dbReference type="EnsemblBacteria" id="AYE33080">
        <property type="protein sequence ID" value="AYE33080"/>
        <property type="gene ID" value="CP523_00735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61249">
        <property type="protein sequence ID" value="QAS61249"/>
        <property type="gene ID" value="EI377_11230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00735"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="11">
        <location>
            <begin position="7"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="10">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="238" mass="25989" checksum="D1E8C2E50C165395" modified="2018-12-05" version="1">MDKCAYKRVILKVSGEALAGQNGFGFDFDIIKRIALEVKALVDMNVEVGLVVGGGNIWRGRSGEGMDRSQADYMGMMATCINALALQDSLEQIGVMTRVQTAIEMKEIAEPFIRRRAVRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILLAKKVDGVYDKDPHKYSDAKKYDTLTYIEVLEQGLQVMDSTATSLCMDNNIPILVFGLEQSGNIKKAISGEKIGTLVSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBG3</accession>
    <name>A0A386PBG3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">CP523_00785</name>
        <name evidence="9" type="ORF">EI377_11280</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674614.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02363"/>
    <dbReference type="EnsemblBacteria" id="AYE33090">
        <property type="protein sequence ID" value="AYE33090"/>
        <property type="gene ID" value="CP523_00785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61259">
        <property type="protein sequence ID" value="QAS61259"/>
        <property type="gene ID" value="EI377_11280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="116" mass="13391" checksum="F20BE626AAF58825" modified="2018-12-05" version="1">MNEILRAIEAEQIRNDLPNFMVGDTVKVYVKIKEGTRERVQMFEGTVIKKQNGGLRETFTVRRVALGTGVERTFPVNSPIIEKMEIVRKGKVRRAKLFYLRDRVGKAAKVKELKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBK1</accession>
    <name>A0A386PBK1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01925</name>
        <name evidence="2" type="ORF">EI377_12445</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678279.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01163"/>
    <dbReference type="EnsemblBacteria" id="AYE33305">
        <property type="protein sequence ID" value="AYE33305"/>
        <property type="gene ID" value="CP523_01925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61475">
        <property type="protein sequence ID" value="QAS61475"/>
        <property type="gene ID" value="EI377_12445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="166" mass="17845" checksum="92720619E306CA6C" modified="2018-12-05" version="1">MIKNFQGKEPKIHKTCYISESVDIIGEVVIGENSNIWFGTRARGDMNKISIGENTNIQENSVVHVDTDFPTIIGDNVTVGHGAIIHGCEISDNVLIGMGSIILNGAKISKNTIVAAGSLVSQGKTFKEGVLLMGSPAKVVRDLTKEEINSIQTSANNYVALSKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBQ5</accession>
    <name>A0A386PBQ5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02245</name>
        <name evidence="8" type="ORF">EI377_12765</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674024.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00518"/>
    <dbReference type="EnsemblBacteria" id="AYE33365">
        <property type="protein sequence ID" value="AYE33365"/>
        <property type="gene ID" value="CP523_02245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61535">
        <property type="protein sequence ID" value="QAS61535"/>
        <property type="gene ID" value="EI377_12765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="28528" checksum="E203C3393EC7F495" modified="2018-12-05" version="1">MHKFFTPRENFSENECTILGDDVKHIYKVLRLAEGEKVILNNCNGEEFLGAIKSVGKQEVVVSILEKLDIDNESEVKIYLFQGLPKSQKMDLIVQKGTELGICEFIPTLTSRVDIKLKGDFKKLDRLNRIALEAAKQSKRSIVPRVTEPVSFESAISEIKLMDLMIVPYENAENFGVKTLMEELKNKDYDLRKIKKIGILVGPEGGFEEDEIAILKENGAYIITLGSRILRTETAGFVATSLIQYELGDLGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC54</accession>
    <name>A0A386PC54_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678408.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01754"/>
    <dbReference type="EnsemblBacteria" id="AYE33525">
        <property type="protein sequence ID" value="AYE33525"/>
        <property type="gene ID" value="CP523_03110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="280" mass="32074" checksum="DB15E4D845795D11" modified="2018-12-05" version="1">MGYYVNVDSGVKVYVEDINEKGDKTIVFLHGWPGSHELFEYQYDYLIQKGFRCIGLDQRGFGKSDRPAYGYDYDTLSDDVKAVVDQLGLSNFTLLGHSTGGAIAIRYMARHWGRGVDKLILCAAAAPSLIRRQYFPYGLKKEDVEEIIKGTYSDRPKMLKNFGDTFFYKKPSKWFMEWFLQLGFQAAGWATAEVANTWLDEEKLFEDIKKIKVPTLIAHGIHDKVCLFPLAEEQKKLIKNSKLIKFQNSGHGVFYDERDKFNKVIVSFIGGSEENTTHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCA9</accession>
    <name>A0A386PCA9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03440</name>
        <name evidence="6" type="ORF">EI377_13965</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677893.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02239"/>
    <dbReference type="EnsemblBacteria" id="AYE33585">
        <property type="protein sequence ID" value="AYE33585"/>
        <property type="gene ID" value="CP523_03440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61749">
        <property type="protein sequence ID" value="QAS61749"/>
        <property type="gene ID" value="EI377_13965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="34712" checksum="BA379B470BB093F5" modified="2018-12-05" version="1">MKILDVKNLYKEYENNVAVDDISFSISKGEIYGLLGPNGAGKSTTISMITGLSKVNSGKVIFEENETNINKWKNNIGLVPQDFALYWELSAEENIKFFCSLYGFKGKELKNRVYKALEFVGLTQFRKKKAKEFSGGMKRRLNMACAIAHTPKLIIMDEPTVGIDPQSRNHILESVKQLRSDGATIIYTSHYMEEVDEICDRISIMDHGNIIAEGSSEHLKNLVSDKNIFSVSLVNKVKGIEENLKTITGIEKVIVEGNEIKCYYLKESNVIEQLVSTISKENGIIKNIKNETPSLETVFLALTGKNLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCF1</accession>
    <name>A0A386PCF1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03695</name>
        <name evidence="9" type="ORF">EI377_14225</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33633">
        <property type="protein sequence ID" value="AYE33633"/>
        <property type="gene ID" value="CP523_03695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61797">
        <property type="protein sequence ID" value="QAS61797"/>
        <property type="gene ID" value="EI377_14225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="268"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="365" mass="42198" checksum="48DE90FB97AE4BA7" modified="2018-12-05" version="1">MINLKKYMKMIFIIIIFSLIVFTFSIVSSILISDYKMNVEINNAQNIDTSYLQFDDSNKVSFNDVINILNDYQKSKIYMEYDPIPKYISNNTLFGKGIYCNYNINNNIPILEGRDFTLKEMNSNDRKVLVGNKLRSYIVKENDKNYFTIGKEKFEVIGILGSIERETGYDYTFIINLKSSDDFSDLRARWRLNVSDENDLKSILNNYKDLAIEHGMNVNISNENYSKVNLIDIFGIHPEFTGVFIMVFGFGLINLIIVVYYWMNKNIKEIGIRKAYGGNDFKISLHIIVQYEIGVIISVIVGILAHLCLKPILIVMFPMFTFKLYYENIIFATVFFMIIGVIVAIIPLIKAKKVQPVTIMKGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCF3</accession>
    <name>A0A386PCF3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01179"/>
    <dbReference type="EnsemblBacteria" id="AYE32994">
        <property type="protein sequence ID" value="AYE32994"/>
        <property type="gene ID" value="CP523_00270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="419" mass="49560" checksum="884EBEA5F6D7F242" modified="2018-12-05" version="1">MSNLNIDKEDIFYVSLLNLNEQIALNLVNKDNNMVIYTEDYYKYKIIKNLVIDRLIKEKKVLIISDNIDNNLFQELNLIKNKVINISNNDIDSIIKNQLKNISKTTGKTTISKLNVLSRNIIKSLKSLEDINNILNIKGYCGLTLLEMYNLSIKVEKGQLSNEYKRYRIKKPLVSYSYDMLKENVNNILKKDIIKDYIKYKRFNKNKIFDIINKPIDKNKINNSIKKLNGLINNPFSIELPVIKSIYTKYFLEYLTKNTFPTEQDISILSKEVNIKVNSSILNYKNIKSKINPLYWVNIKKYKSDLEESKKNFNIHENIIYLEYIENQKNISIYLHAFNFLKDIITDEEFKKFLKKLLDTNDTIEYLKSLRDTLVIVRNFNIILEKIESLNNVEKEILEYCYNNIENKNQFESLLTNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCF8</accession>
    <name>A0A386PCF8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="5" type="ORF">CP523_02760</name>
        <name evidence="6" type="ORF">EI377_13285</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676968.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00958"/>
    <dbReference type="EnsemblBacteria" id="AYE33460">
        <property type="protein sequence ID" value="AYE33460"/>
        <property type="gene ID" value="CP523_02760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61631">
        <property type="protein sequence ID" value="QAS61631"/>
        <property type="gene ID" value="EI377_13285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="163" mass="17496" checksum="6B3C8DF33ED9870A" modified="2018-12-05" version="1">MHAKNEVRVGIADYSIVFAPGSVITMGLGSCVGIAFYDRIKKVAGLVHIMLPDSTQFKNITNPMKYADLAVPALLDKMMKLGCSKRNIVVKIAGGASMFNFTDKKIVSDIGKRNIEATKNIINLLGLTLISEDVGGDKGRTMIVEAENGTVKIRVVGAGIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCI6</accession>
    <name>A0A386PCI6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_01345</name>
        <name evidence="8" type="ORF">EI377_11845</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675574.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00820"/>
    <dbReference type="EnsemblBacteria" id="AYE33197">
        <property type="protein sequence ID" value="AYE33197"/>
        <property type="gene ID" value="CP523_01345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61367">
        <property type="protein sequence ID" value="QAS61367"/>
        <property type="gene ID" value="EI377_11845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="6">
        <location>
            <begin position="58"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="5">
        <location>
            <begin position="410"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="5">
        <location>
            <begin position="769"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="662"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="961" mass="107934" checksum="30D7703DE42CFB3A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCL6</accession>
    <name>A0A386PCL6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">truB</name>
        <name evidence="7" type="ORF">CP523_00655</name>
        <name evidence="8" type="ORF">EI377_11145</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676368.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00662"/>
    <dbReference type="EnsemblBacteria" id="AYE33064">
        <property type="protein sequence ID" value="AYE33064"/>
        <property type="gene ID" value="CP523_00655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61233">
        <property type="protein sequence ID" value="QAS61233"/>
        <property type="gene ID" value="EI377_11145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="292" mass="33064" checksum="C5AFB84D099C2DCB" modified="2018-12-05" version="1">MNGVINIFKNKGMTSFDVVRKIKKITGTGKVGHTGTLDPEATGVLPVCIGKATKIIDYIMNTEKGYEVEFKLGVKTTTYDLEGDIIEEKDINHLNDDEILKAIYSFVGEYSQVPPMYSALKQNGVRLYELARRGIEVHREGRLITIYNIENVVIKGAYIRMKVTCSKGTYIRSLCFDIGEALGVGACMTDLKRFKTSVFLEEDSINIDDLTEDNISNYIISMEEALKTYEKITVGNKYGKLLINGVRVFDNRISKDKIEIDKLYRVYNEDEIFIGLGRKNNQGFKMEKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD80</accession>
    <name>A0A386PD80_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05380</name>
        <name evidence="2" type="ORF">EI377_15945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677983.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33945">
        <property type="protein sequence ID" value="AYE33945"/>
        <property type="gene ID" value="CP523_05380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62097">
        <property type="protein sequence ID" value="QAS62097"/>
        <property type="gene ID" value="EI377_15945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="144" mass="16583" checksum="5F7CC6A64A86122C" modified="2018-12-05" version="1">MKNELKALQNEENKIIIKCYREVKNTEVVLSFLTSFVMASEIFSPSGEVISDYVLTATNKNLYIEEIYHAPYGGVADVANSYKIPFESIEEFKVEKKDELEYITIVAEKKPAFLSRKKRMLSLIHKDPLNENKAMKMKELIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDF2</accession>
    <name>A0A386PDF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33820">
        <property type="protein sequence ID" value="AYE33820"/>
        <property type="gene ID" value="CP523_04700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="310" mass="37735" checksum="AA793C685BAD2186" modified="2018-12-05" version="1">MIHTAEFYINFHEKQRDFLEKKYKKELFKVESLINKIYKDTGITIHSIKRVYGIYRLNFTIDFIKLLKKAEIVEEDIIQIEDKIYGFIYDITGSNFIEPYMKRLDYRYDAIVNEDQRKVLFHIYKKTMDRYGFKKKYNGFDTTIYYNSRSIVSKVYDKERERIVKNKEIMAYEKNILRFEISLNNDHLNYNKRRYNLNKDISLYLNESMYIIYFKRHLEVFTYSGDYYNIYNARKMINSSKINEKDKNELIEFLKYISKKGVTEAKEKYSSYYFKKYITYLKELKINPILIPKNLKGASSYIKNPFNICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDN3</accession>
    <name>A0A386PDN3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliS</name>
        <name evidence="7" type="ORF">CP523_02675</name>
        <name evidence="8" type="ORF">EI377_13200</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676943.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00941"/>
    <dbReference type="EnsemblBacteria" id="AYE33444">
        <property type="protein sequence ID" value="AYE33444"/>
        <property type="gene ID" value="CP523_02675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61615">
        <property type="protein sequence ID" value="QAS61615"/>
        <property type="gene ID" value="EI377_13200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="126" mass="14394" checksum="A8B03D193741909D" modified="2018-12-05" version="1">MYGNAYNIYKNNSVNYASKEQLLLMLVDGAVKFAKIAREGLANKDVNKSHDNLVKVQNIFTELIVSLDKDSGEWADQLLGVYIFIKDKLVQANITKNVEYLDEVLPLIDEVKNIWHEAYEVSKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDV9</accession>
    <name>A0A386PDV9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione biosynthesis bifunctional protein GshAB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Gamma-GCS-GS</fullName>
            <shortName evidence="10">GCS-GS</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate--cysteine ligase</fullName>
                <ecNumber evidence="10">6.3.2.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Gamma-ECS</fullName>
                <shortName evidence="10">GCS</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Gamma-glutamylcysteine synthetase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutathione synthetase</fullName>
                <ecNumber evidence="10">6.3.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">GSH synthetase</fullName>
                <shortName evidence="10">GS</shortName>
                <shortName evidence="10">GSH-S</shortName>
                <shortName evidence="10">GSHase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Glutathione synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">gshB</name>
        <name evidence="10" type="synonym">gshAB</name>
        <name evidence="10" type="synonym">gshF</name>
        <name evidence="13" type="ORF">CP523_01365</name>
        <name evidence="14" type="ORF">EI377_11875</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-cysteine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + glutathione + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="10"/>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675580.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00824"/>
    <dbReference type="EnsemblBacteria" id="AYE33201">
        <property type="protein sequence ID" value="AYE33201"/>
        <property type="gene ID" value="CP523_01365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61373">
        <property type="protein sequence ID" value="QAS61373"/>
        <property type="gene ID" value="EI377_11875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01365"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00782">
        <property type="entry name" value="Glut_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007370">
        <property type="entry name" value="Glu_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006335">
        <property type="entry name" value="Glut_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006334">
        <property type="entry name" value="Glut_cys_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040657">
        <property type="entry name" value="GshAB_ATP-grasp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38761">
        <property type="entry name" value="PTHR38761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18419">
        <property type="entry name" value="ATP-grasp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04262">
        <property type="entry name" value="Glu_cys_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01435">
        <property type="entry name" value="glu_cys_lig_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="512"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate--cysteine ligase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="773" mass="89554" checksum="A3117C6EE3970CF5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDX3</accession>
    <name>A0A386PDX3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05670</name>
        <name evidence="2" type="ORF">EI377_00105</name>
        <name evidence="3" type="ORF">EI377_16180</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33990">
        <property type="protein sequence ID" value="AYE33990"/>
        <property type="gene ID" value="CP523_05670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59354">
        <property type="protein sequence ID" value="QAS59354"/>
        <property type="gene ID" value="EI377_00105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62131">
        <property type="protein sequence ID" value="QAS62131"/>
        <property type="gene ID" value="EI377_16180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="134" mass="16099" checksum="82DF897D672BD1F9" modified="2018-12-05" version="1">MNFSVEYESIKDSIVYSFEEYVEEDGFTAPQAAAKTFEEEWRRLNYNMFTKTTYYICTAIECFKLKEIPDFIYDKLDMYINCTDFEDDIKKQDIEQLLQDIRECKELMELKNYKIIESSYGAKSRIEYILSLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE60</accession>
    <name>A0A386PE60_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00070</name>
        <name evidence="2" type="ORF">EI377_10550</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678949.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00299"/>
    <dbReference type="EnsemblBacteria" id="AYE32956">
        <property type="protein sequence ID" value="AYE32956"/>
        <property type="gene ID" value="CP523_00070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61128">
        <property type="protein sequence ID" value="QAS61128"/>
        <property type="gene ID" value="EI377_10550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="406" mass="45001" checksum="4927B96D788E30CE" modified="2018-12-05" version="1">MKKVIVIGAGPAGMMAAIAASNENEVILLDGNERIGKKLFITGKGRCNVTNSKDISEFFEFIPGNPYFLYSSLYTFTNEDTIKFFEDQGIKLKVERGGRVFPESDKSSDIIRGLSNALSKAHVKIKLNSKVTNIISENNIIKEVEINNKEKIKGDYFIICTGGASYPLTGSTGEGQKFSKKLGHNIIDLKPSLVPIEINDIWVKDLMGLSLKNIEISIFEEGKKKAIYKNQGEMIFTHFGISGPLILSGSRFIKENKKFNIKLDLKPALSENELDKRIQKDFKKFINKDFKNSLDELLPKKLIPLIITLSKIPENKKVNEITKEERKALVNLLKGFNMEVKGLRPITEAIVTAGGVDTKEIDPSTMKSKIIKNLSFAGEVIDVDAFTGGYNVQIALATGFVAGTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC6</accession>
    <name>A0A386PEC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33807">
        <property type="protein sequence ID" value="AYE33807"/>
        <property type="gene ID" value="CP523_04630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025935">
        <property type="entry name" value="AbiH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14253">
        <property type="entry name" value="AbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="155" mass="18691" checksum="D1E66DC7F29BC829" modified="2018-12-05" version="1">MRYLNLNIIGNGFDLYHGLPSSYYYFGCYLIMNNTEFYEEVGKMYNFRYMKPIGPPIAHDYEYVVEDIFWKDFERHLGEVDEFFIIDTHEDDLGLEYNDPVDIEMNEDKVAESLKRYFVQWVINTLDKDENYDIIARMIKKIDSVILFNSDDYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED3</accession>
    <name>A0A386PED3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Six-cysteine peptide SCIFF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">scfA</name>
        <name evidence="1" type="ORF">CP523_00405</name>
        <name evidence="2" type="ORF">EI377_10895</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678151.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00592"/>
    <dbReference type="EnsemblBacteria" id="AYE33016">
        <property type="protein sequence ID" value="AYE33016"/>
        <property type="gene ID" value="CP523_00405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61185">
        <property type="protein sequence ID" value="QAS61185"/>
        <property type="gene ID" value="EI377_10895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023975">
        <property type="entry name" value="Six-Cys_pep_SCIFF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13165">
        <property type="entry name" value="SCIFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03973">
        <property type="entry name" value="six_Cys_in_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="45" mass="4845" checksum="E82F3EEB9B6C8CD6" modified="2018-12-05" version="1">MKHIKTVNKTNIKNSLAKPGCKECANSCQSACKTSCTVANLECEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEF6</accession>
    <name>A0A386PEF6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04790</name>
        <name evidence="3" type="ORF">EI377_15300</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33837">
        <property type="protein sequence ID" value="AYE33837"/>
        <property type="gene ID" value="CP523_04790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61983">
        <property type="protein sequence ID" value="QAS61983"/>
        <property type="gene ID" value="EI377_15300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="24637" checksum="75F3316C9C2CB2A4" modified="2018-12-05" version="1">MYLMKNIKQIFDYKIKEFLALSGGLTLIFLLTRLDTPDFIDGYMLAILITISMMGRYNFVSEHIVKEDSIYLKKHKATLKYIISKNLVTLFLVMILVFIVFLLEFIITKATLSYEFYFKSLILSILTMAFNNIIFMFNNKPEKSSSAEFDEWTSIVLGFKSLINSLPSILIVFIILYFNKYLYNINMYDALIVEIMSIILLNFKLKSEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEG8</accession>
    <name>A0A386PEG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Energy-coupled thiamine transporter ThiT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiT</name>
        <name evidence="2" type="ORF">CP523_08340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01609"/>
    <dbReference type="EnsemblBacteria" id="AYE34435">
        <property type="protein sequence ID" value="AYE34435"/>
        <property type="gene ID" value="CP523_08340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012651">
        <property type="entry name" value="Thia_Transptr_ThiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09515">
        <property type="entry name" value="Thia_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02357">
        <property type="entry name" value="ECF_ThiT_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="213" mass="23216" checksum="2CD30315C5D16438" modified="2018-12-05" version="1">MSNLKESFSTLMDNPLSLITIIGGVLLLLAIIKFKNIKLNAKIMTRIGIDLALATILNMIKLYVLPNGGGSISLGSMVPIILIAYMYGPQIGLLTGFLFGIISLILNPYILHPIQVLFDYPLPYMAVGFAGYFKNNRMLGTTVGMSLKFVFHFISGYVFFGEFAPAGWSPAIYSLAVNGFAVGGELVICLIIISLLPFNRIINNISNKSQSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH2</accession>
    <name>A0A386PEH2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="8">S12 MTTase</shortName>
            <shortName evidence="8">S12 methylthiotransferase</shortName>
            <ecNumber evidence="8">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rimO</name>
        <name evidence="12" type="ORF">CP523_00610</name>
        <name evidence="13" type="ORF">EI377_11100</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676358.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00653"/>
    <dbReference type="EnsemblBacteria" id="AYE33056">
        <property type="protein sequence ID" value="AYE33056"/>
        <property type="gene ID" value="CP523_00610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61225">
        <property type="protein sequence ID" value="QAS61225"/>
        <property type="gene ID" value="EI377_11100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="142"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="375"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="445" mass="51286" checksum="0AA1F5B732C1698E" modified="2018-12-05" version="1">MQKYKVGMVSLGCDKNRVDSELILGSINKYYEITNNPKEADIIIVNTCGFIEKAKQESIDTILEMAEYKNKYKCKMLIATGCLTQRYGDELLELMPEIDILMGVNDYMKLHKLIMQFIKDEKQISSAEYSDNNINEGIRLLTTDKHTAYVRIAEGCNNFCTYCIIPKIRGKFRSRKMENILEEVKSLSNQGVKEIILIAQDLTCYGIDIYQGKKLHKLISEISKVEGIEWIRLLYCYPEEITEELIEEIATNKKVVKYLDLPIQHISNNILRLMARKTNKQTIIEKIEKLKKKVPGIVLRTSLIVGFPGETDEDFEELKEFLKEYKLDNVGVFKYSREEGTPAANMENQITEEIKDVREKELMNVQKMVSKSLNELKVSKVYDTIIEGQKGKYFLGRSAEMAPEIDGVIYIDSNKNLSKGDIIKVKIKEALEYDLIGEVYNEFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI9</accession>
    <name>A0A386PEI9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04945</name>
        <name evidence="2" type="ORF">EI377_15445</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675729.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33867">
        <property type="protein sequence ID" value="AYE33867"/>
        <property type="gene ID" value="CP523_04945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62010">
        <property type="protein sequence ID" value="QAS62010"/>
        <property type="gene ID" value="EI377_15445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="16433" checksum="A80CF5D798CFAC55" modified="2018-12-05" version="1">MIKLKEDCITNILKEYIKDNKEYIKKEAGEFIINKASINDYDFMRCKYKLEKLKIEEKLDLINFAFKYSYILFKIIEEDIIDKKDLISVKFAFFETKFAIIEYLAMRESEEDLKSKIKRSFNDLKISNDVIKAIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN6</accession>
    <name>A0A386PEN6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673759.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34270">
        <property type="protein sequence ID" value="AYE34270"/>
        <property type="gene ID" value="CP523_07305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="150" mass="17904" checksum="54299581C1AD1B5C" modified="2018-12-05" version="1">MDFLRDQGLIYTSKKYEEIYIFLKERYDISYDQLFTLCAVVGFKNNRALERESRGREFRGSYLKRDNKASLYSIILNDEDLGKQIDSFEKSEYQKECIKKLEKYAEGGMEILVEEVFRGKLGTNKLDERYDEYIIDIISYVYENSIELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP2</accession>
    <name>A0A386PEP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transketolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05215</name>
        <name evidence="3" type="ORF">EI377_15775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676241.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01832"/>
    <dbReference type="EnsemblBacteria" id="AYE33917">
        <property type="protein sequence ID" value="AYE33917"/>
        <property type="gene ID" value="CP523_05215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62068">
        <property type="protein sequence ID" value="QAS62068"/>
        <property type="gene ID" value="EI377_15775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="308" mass="32740" checksum="ABE6E21337168F83" modified="2018-12-05" version="1">MGKATRESYGMALVELGKENENVVVLDADLSKSTKTADFKKEFSDRFFNAGIAEQNLMGMAAGLANVGKVPFASTFAVFASGRAFEVIRNSICYPKVNVKIAATHAGITVGEDGGSHQSVEDIALMTSLPNMTVIVPADHREAMAAVKAAAEMNGPVYLRFGRCATEDIYDENYKFEIGKGSQLTEGNDVAIIATGMLVAKALEAAKELEAEGIKARVINIATIKPIDRELIIKAAKETKGIVTAEEHSVIGGLGAMVSSVVCEECPTKVKKVGIQDTFGESGTPNELMEKYGLTAAEIVKAAKEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX5</accession>
    <name>A0A386PEX5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09235</name>
        <name evidence="9" type="ORF">EI377_03980</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678324.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03051"/>
    <dbReference type="EnsemblBacteria" id="AYE34593">
        <property type="protein sequence ID" value="AYE34593"/>
        <property type="gene ID" value="CP523_09235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59993">
        <property type="protein sequence ID" value="QAS59993"/>
        <property type="gene ID" value="EI377_03980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="174" mass="18819" checksum="DF99D9682C209B55" modified="2018-12-05" version="1">MSLLFKLFFSFLKIGTFSFGGGYAMLPFIEREIVTKNQWINMNEFMDIIGISQMTPGPVAINSATFVGYKVIGVSGSIAATLGVVLTSFILVSIASKALTSFKNSVIVKSALLGMRPVLIALIISAFLRLAKESYLDLKSLVITTIIGIVLLSKKVHPILVIVLAAILGIIFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY9</accession>
    <name>A0A386PEY9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00590</name>
        <name evidence="2" type="ORF">EI377_11080</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016206312.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00649"/>
    <dbReference type="EnsemblBacteria" id="AYE33052">
        <property type="protein sequence ID" value="AYE33052"/>
        <property type="gene ID" value="CP523_00590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61221">
        <property type="protein sequence ID" value="QAS61221"/>
        <property type="gene ID" value="EI377_11080"/>
    </dbReference>
    <dbReference type="GeneID" id="66301600"/>
    <dbReference type="KEGG" id="csep:CP523_00590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007347">
        <property type="entry name" value="SpoVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35331">
        <property type="entry name" value="PTHR35331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04232">
        <property type="entry name" value="SpoVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="86" mass="8939" checksum="2813E0CE83329CCC" modified="2018-12-05" version="1">MEVLKVSTKSNPNSVAGALAAIIKEKNIVEIQAVGAGAINQAVKAIAIARGFVAPSGKDIVCVPAFTDIEIDGEERTAIKLIVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF00</accession>
    <name>A0A386PF00_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04720</name>
        <name evidence="5" type="ORF">EI377_15230</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33824">
        <property type="protein sequence ID" value="AYE33824"/>
        <property type="gene ID" value="CP523_04720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61970">
        <property type="protein sequence ID" value="QAS61970"/>
        <property type="gene ID" value="EI377_15230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="124" mass="13665" checksum="D17669FF21E3D046" modified="2018-12-05" version="1">MEFSKLYEIAKATLNPRELSRSAYAASVAAAILTEKGNVYKGVCIDTPSSMGFCAEHATIATMITAGESCIVKMVAVYRSGEIVAPCGRCREFINQIDYNNYKCEVMLKDKILTISDLLPEPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF02</accession>
    <name>A0A386PF02_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08050</name>
        <name evidence="2" type="ORF">EI377_02810</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675940.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34380">
        <property type="protein sequence ID" value="AYE34380"/>
        <property type="gene ID" value="CP523_08050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59786">
        <property type="protein sequence ID" value="QAS59786"/>
        <property type="gene ID" value="EI377_02810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="10583" checksum="5BAFADE75A3250B5" modified="2018-12-05" version="1">MGNCLKDELINIYTTLVESGTIFYYGNESISYGEVTSFAIGENEKLEIELNGFETYNIELEDFEKNHSKEGVNYHSWGMVREFDNVLGKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF04</accession>
    <name>A0A386PF04_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 14">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
        <name evidence="16" type="ORF">CP523_01595</name>
        <name evidence="17" type="ORF">EI377_12115</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12 14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675679.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00872"/>
    <dbReference type="EnsemblBacteria" id="AYE33246">
        <property type="protein sequence ID" value="AYE33246"/>
        <property type="gene ID" value="CP523_01595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61418">
        <property type="protein sequence ID" value="QAS61418"/>
        <property type="gene ID" value="EI377_12115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="75"/>
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        </location>
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        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <begin position="240"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <begin position="277"/>
            <end position="284"/>
        </location>
        <ligand>
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        <location>
            <position position="368"/>
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        <ligand>
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            <position position="410"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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        <location>
            <begin position="140"/>
            <end position="145"/>
        </location>
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    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="563" mass="61314" checksum="E13CEA19E35804C2" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF06</accession>
    <name>A0A386PF06_CLOSE</name>
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        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
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        <name type="scientific">Clostridium septicum</name>
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                <person name="Leendertz F.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
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        </reaction>
    </comment>
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        <property type="gene ID" value="EI377_13275"/>
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    <dbReference type="GO" id="GO:0008983">
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        <property type="project" value="UniProtKB-EC"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS61629.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="255" mass="29960" checksum="4A3E0F00D755390B" modified="2018-12-05" version="1">MDFNDFHQWVFKELGVNLNAYKPEQLNRRIGSLMSRVGVKSLEEYKIILSKDKEQRERFLDFITINVTEFFRNPEIFKQLEEAIKNELLTSNSKIKVWSAACSIGCEPYSLGILLKELNPLGRNTILATDIDKGILEKAKLGEYTLAEMKNVREEYINKYFKNVDNKYIIDSNIKSMITFKRHDLILDTYERDFDLIVCRNVVIYFKNDVKNEIFNKFSNSLKKGGLLFIGATESIYNYKDYNLEKVSTFIYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF58</accession>
    <name>A0A386PF58_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03020</name>
        <name evidence="3" type="ORF">EI377_13520</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01773"/>
    <dbReference type="EnsemblBacteria" id="AYE33508">
        <property type="protein sequence ID" value="AYE33508"/>
        <property type="gene ID" value="CP523_03020"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61674"/>
        <property type="gene ID" value="EI377_13520"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="342" mass="39614" checksum="84C7E787113342B5" modified="2018-12-05" version="1">MIIYEDSYRNENFYNHDENFYNHDENLNEYSTDSNRIPPFGNFPQPPNNPGINNPSMKLGKPPSYIPSKNDPGVQSFNSSKSKGVSTKAVSPNAISFCLYKFTYIWEVSGRSYWIYLITVDKVSISGFRWMGFNWGYFGIDLKKIDSFICYRSNSSNEDCTGYCYKNPNDTFRENIKTEFSNEGVKNIYSRVLSVVDIPEYKEDVFIENIGSIDGRTIESKIPCTKTRTVSYKITLEVSYPENISDSLKEQINLAARDSSIDAYEMLTSIRSQERYIYPLAIENSSSDLISKSLSYFSKKFSSQIRSLPNWKELSRRIHYSIRHEQVPGNWNIQNMSNINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF76</accession>
    <name>A0A386PF76_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_08470</name>
        <name evidence="11" type="ORF">EI377_03220</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674831.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34460">
        <property type="protein sequence ID" value="AYE34460"/>
        <property type="gene ID" value="CP523_08470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59863">
        <property type="protein sequence ID" value="QAS59863"/>
        <property type="gene ID" value="EI377_03220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="9">
        <location>
            <begin position="94"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="196"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="407" mass="42465" checksum="F14CD3F5D44612EB" modified="2018-12-05" version="1">MNRFIGIIGIIAIFGIAFLFSENKKKINWRLVATGLGLQIVLALLILKVPAGRKVFEGASAAITKLLDFTKEGTNFLFGSLADSSSSVGFVWVVQILPTIVFFSSLMGVLYYLGVMQAIVKFIAKFICKLLGTSGSETLSAVGNIFLGQTEAPLLVKPFVKTMTRSEIMAIMIGGMATVAGGVMAGYVAMGVPAGHLLTASIMAAPAGLILAKILVPETEESETKNSADIEVEITASNVVEAAANGASDGLGLALNVGAMLLAFIALLALLNFIIGSIGGIFGFPGLSFQWIIGKIFSPLVFIMGVPTQDISVAGSLLGQKIILNEFVAYSELSNYIVAGTLHEKTVMMLTYALCGFANFSSIAIQIAGIGGLAPEKKKTIASLGFKSLLGGVLATCLTATIAGVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF84</accession>
    <name>A0A386PF84_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cro/Cl family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02040</name>
        <name evidence="3" type="ORF">EI377_12560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678874.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00124"/>
    <dbReference type="EnsemblBacteria" id="AYE33326">
        <property type="protein sequence ID" value="AYE33326"/>
        <property type="gene ID" value="CP523_02040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61496">
        <property type="protein sequence ID" value="QAS61496"/>
        <property type="gene ID" value="EI377_12560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="179" mass="20840" checksum="D83506063BF0F14B" modified="2018-12-05" version="1">MQIGEKIRRLRIEKQLTQEELANRCELSKGFISQVENDLTSPSIATLVDILEILGTNLTEFFSEDSEERVTYTYEDMFETDNEDLKYKLMWLVPNAQKNEMEPIMITLEPKGQYIEEEPHEGEEFGYVLSGTIVLHLGEKKFKVKKGESFYYKPKVNHYISNPHKTPAKVIWISTPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF95</accession>
    <name>A0A386PF95_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Beta-galactosidase</fullName>
            <ecNumber evidence="3 9">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_04000</name>
        <name evidence="12" type="ORF">EI377_14520</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02786"/>
    <dbReference type="EnsemblBacteria" id="AYE33691">
        <property type="protein sequence ID" value="AYE33691"/>
        <property type="gene ID" value="CP523_04000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61846">
        <property type="protein sequence ID" value="QAS61846"/>
        <property type="gene ID" value="EI377_14520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011081">
        <property type="entry name" value="Big_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013222">
        <property type="entry name" value="Glyco_hyd_98_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038637">
        <property type="entry name" value="NPCBM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07532">
        <property type="entry name" value="Big_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08305">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00776">
        <property type="entry name" value="NPCBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Dockerin" evidence="10">
        <location>
            <begin position="1604"/>
            <end position="1667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1667" mass="188647" checksum="B3BA4A496ABDA68E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD2</accession>
    <name>A0A386PFD2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01425</name>
        <name evidence="4" type="ORF">EI377_11945</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675601.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33212">
        <property type="protein sequence ID" value="AYE33212"/>
        <property type="gene ID" value="CP523_01425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61384">
        <property type="protein sequence ID" value="QAS61384"/>
        <property type="gene ID" value="EI377_11945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="26135" checksum="6BD9A49760CD77CE" modified="2018-12-05" version="1">MSNLYSMRNENIKISKNLTGENQKIFTDIVCYLRVSKLNEIEQEEVINDILTIFFDCEKDKKDIQSVIGNDFKKFTDEIISAVNPKTSIFNKIKEFLIILIQSLGIILTLDFIVFYLPKIINGNFALTYTFTLSMVIHFLILLIIAIFLINYVGKNSFKLSETKYSIFKRFIIGASTGAIFVLLIFLNKIFNDINLLSLNIGWILGIIIVFWCCMLTKRIKNRLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI0</accession>
    <name>A0A386PFI0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal-body rod modification protein FlgD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_02585</name>
        <name evidence="5" type="ORF">EI377_13120</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for flagellar hook formation. May act as a scaffolding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673919.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00450"/>
    <dbReference type="EnsemblBacteria" id="AYE33426">
        <property type="protein sequence ID" value="AYE33426"/>
        <property type="gene ID" value="CP523_02585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61600">
        <property type="protein sequence ID" value="QAS61600"/>
        <property type="gene ID" value="EI377_13120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="24210" checksum="E90FAE9B17D8BFE6" modified="2018-12-05" version="1">MSNVINNNYGARATERGTKIMKPGEDMDKNAFLKILSAELSNMDPMGNNDSTQYITQMAQFASMEQMSNLNNTMSSYASHSLVGKGVTMKSVDSDGKPYTGVVKAVTIQNGKTTLSVEVNENGQNSYKDFSLDDVITVLDVPDYSIPPLNNMNGNMSFLLASSFIGKHVELNEQDDNKKNIEGEVLSVIKESGLIKVKVKLQGSEEIKDFDYDKVIKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ4</accession>
    <name>A0A386PFQ4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MurNAc-LAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34895">
        <property type="protein sequence ID" value="AYE34895"/>
        <property type="gene ID" value="CP523_11010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017192855" description="MurNAc-LAA domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1333" mass="145087" checksum="8AF7670BBEBE36D8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS5</accession>
    <name>A0A386PFS5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoVAE</name>
        <name evidence="2" type="ORF">CP523_02340</name>
        <name evidence="3" type="ORF">EI377_12860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673991.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00499"/>
    <dbReference type="EnsemblBacteria" id="AYE33382">
        <property type="protein sequence ID" value="AYE33382"/>
        <property type="gene ID" value="CP523_02340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61553">
        <property type="protein sequence ID" value="QAS61553"/>
        <property type="gene ID" value="EI377_12860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014204">
        <property type="entry name" value="Spore_V_AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02839">
        <property type="entry name" value="spore_V_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="118" mass="11954" checksum="0319113F695D550A" modified="2018-12-05" version="1">MQFVNAFIIGGLICVVGQILMDTTKLTPARILVIFVTLGAILGAFGLYDKLIDIGGAGASVPLPGFGNSLAKGAIKAVNEKGLIGAFTGGISGTAAGITAAIFFGYIMACIFNPKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG22</accession>
    <name>A0A386PG22_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YicC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00990</name>
        <name evidence="4" type="ORF">EI377_11485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674516.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02321"/>
    <dbReference type="EnsemblBacteria" id="AYE33129">
        <property type="protein sequence ID" value="AYE33129"/>
        <property type="gene ID" value="CP523_00990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61299">
        <property type="protein sequence ID" value="QAS61299"/>
        <property type="gene ID" value="EI377_11485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="293" mass="33518" checksum="E057DD49C2CD5E89" modified="2018-12-05" version="1">MVKSMTSFGRASSSEGSKHLFSIEMKSVNSRYLDINVRMPKSIIALEEDIRKIVSETLSRGKVDIFINQKSYSKGDGVAKVNLKLAESYLNSLKELESTFGIKNDITISQLARFQDIITVVEEEDSIEEIATTIKPLIKESLLMMDKMRSIEGEKLKEDILNKVNDIELLVKKIEEISETVPKAYRKKLENRLKELTQGLEIDESRIAQEIAIFSDKACVDEEITRLYSHLNQMRKTFEEEGTIGRKLDFIIQEMNREANTIASKSSDMDMTNLVINIKNLIEKIREQGQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG65</accession>
    <name>A0A386PG65_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">lon</name>
        <name evidence="13" type="ORF">CP523_11875</name>
        <name evidence="14" type="ORF">EI377_06695</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02933"/>
    <dbReference type="EnsemblBacteria" id="AYE35055">
        <property type="protein sequence ID" value="AYE35055"/>
        <property type="gene ID" value="CP523_11875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60449">
        <property type="protein sequence ID" value="QAS60449"/>
        <property type="gene ID" value="EI377_06695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="589"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="777" mass="87677" checksum="04FF363073C799D6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG88</accession>
    <name>A0A386PG88_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05890</name>
        <name evidence="9" type="ORF">EI377_00380</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675022.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34031">
        <property type="protein sequence ID" value="AYE34031"/>
        <property type="gene ID" value="CP523_05890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59404">
        <property type="protein sequence ID" value="QAS59404"/>
        <property type="gene ID" value="EI377_00380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="299"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="46130" checksum="75DE80842B69CF5E" modified="2018-12-05" version="1">MYLGYIKSSIRNKKLFTLLSIVQITITMVLVIDVLINLSTINYKEREFKNNLNVNLNNTYKFSVYGNGSGKVDLKKKLSNYFDIGSYKYESLGNMYYTEVQEPTNRVNILKADKNIFNLLDINITDGRNLNEDDFNLDKDKIPIIFSEEYKGRLNIGDTITNKVLTKENYEVVGFYNKDIKWFPRNDIQFFALEDLGKMGITIPSKKERELLFYEMEINSATYITSDKLNKSEIQNIIDDVNKEYGLNVEILSIKDILNRFKQGIYPFILQTVFFSIFMLVSSCLGLASNMSFTIINRKKEFGIRLANGFRKKDIKLLVISEMLFLSLISTIIAMIFKFTELYKNRQFSIAEKIIVPQFSIIDFVVAIVLVVIIIVISSIIPLRNIDKLQPKEMIGGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB5</accession>
    <name>A0A386PGB5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK</name>
        <name evidence="13" type="ORF">CP523_04075</name>
        <name evidence="14" type="ORF">EI377_14595</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02771"/>
    <dbReference type="EnsemblBacteria" id="AYE33706">
        <property type="protein sequence ID" value="AYE33706"/>
        <property type="gene ID" value="CP523_04075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61861">
        <property type="protein sequence ID" value="QAS61861"/>
        <property type="gene ID" value="EI377_14595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04075"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="8"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="174"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="301" mass="32245" checksum="5DA7D0AD4661B316" modified="2018-12-05" version="1">MIYNGVLELIGKTPILKVSNLEENSADVYVKLEKFNPGGSVKDRAALGMIEKAEKLGLIKPGDTIVEPTSGNTGIGLAMIGRLKGYKVVIIMPETMSKERRDLIKAYGASLVLTEGAEGMKGAIEKANELVKQHGYFMPQQFENLANPEKHYETTAEEIYNYLSDLDVFVAGVGTAGTVTGISKNLKNKIKKLEVVAVEPEKSPVISGGKAGAHKIQGIGAGFVPKIYNSEYIDKVMTVSDEDALRTTKEFAINEGILVGISSGAAIYAAMKIAKILGKGKKVLAIAPDGGEKYISMGIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG6</accession>
    <name>A0A386PGG6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2304 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10885</name>
        <name evidence="3" type="ORF">EI377_05680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677633.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34870">
        <property type="protein sequence ID" value="AYE34870"/>
        <property type="gene ID" value="CP523_10885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60265">
        <property type="protein sequence ID" value="QAS60265"/>
        <property type="gene ID" value="EI377_05680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019277">
        <property type="entry name" value="DUF2304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10066">
        <property type="entry name" value="DUF2304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="122" mass="14127" checksum="F8F6B422BA3C4A12" modified="2018-12-05" version="1">MNSRAFFAVVGILFMIIILVSVRKKKFFVKDSFYWFLLSVGILLLSIFPSIIRVVANVVEVEYAPSLLFFIAIIFILYIVFNLSQQVSLLREQNKDLAQRVAVLKKIINDIEKDKEKNNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH2</accession>
    <name>A0A386PGH2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ORF">CP523_01780</name>
        <name evidence="12" type="ORF">EI377_12300</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677315.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02395"/>
    <dbReference type="EnsemblBacteria" id="AYE33279">
        <property type="protein sequence ID" value="AYE33279"/>
        <property type="gene ID" value="CP523_01780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61450">
        <property type="protein sequence ID" value="QAS61450"/>
        <property type="gene ID" value="EI377_12300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01780"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="475" mass="51867" checksum="0F374E57F5893666" modified="2018-12-05" version="1">MNSSLELILDPSNDKFKDECGVFGVYANREMDVASMTYYGLYALQHRGQESAGIAVANGDVVNIHKGMGLITEAFSQSDLNKLQGNAAIGHVRYSTSGDTRIENAQPLLSKTKLGSIAMAHNGTLVNAEVIRELLEDGGHVFHTSIDSEVIANLIARGAKKGIERAVLDAIQAVRGSFAMVILTENKLIGVRDPHGIRPLCLGKFEDGYVLSSESCALDAIGAELVRDIDPGEIVVIDECGINSYRYSENTQCQTCAFEYIYFARPDSTIDGLDVHESRVKAGQELFKQYPIEADIVVAVPDSGIPAAIGYAKASGIPYDTGFVKNRYVGRTFITPSQEIRERAVAVKLNPLKVNIKDKKVVLIDDSIVRGTTSKHLVDSLKRAGAKEVHFLVASPIVKFPCYFGIDTPYRSELIGTKGSVDEIREMIGCDTLGYLDIENMYKCFKENSGYCVGCFNGVYPVATPIETAKDHIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH7</accession>
    <name>A0A386PGH7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06420</name>
        <name evidence="4" type="ORF">EI377_00895</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02160"/>
    <dbReference type="EnsemblBacteria" id="AYE34131">
        <property type="protein sequence ID" value="AYE34131"/>
        <property type="gene ID" value="CP523_06420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59498">
        <property type="protein sequence ID" value="QAS59498"/>
        <property type="gene ID" value="EI377_00895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="491" mass="53685" checksum="0ACBC1D356FEC241" modified="2018-12-05" version="1">MNDLAKSVRNVMVVFLFCFIGLISYMAYFQLFKGPDIAEDPKNVRLWAKRNEVLRGTIYDRQGNPLTKSERQDTLTQKREYLQGDLYVHALGYVDERYGLTGLEEEFDSELSTYNTFTTGFRNLFKDFDLKKAFSERDKEEDKKVGNGLVTTLDYNIQKVAYDALGDMKGSVVALNPKTGEILAMVSKPTYDPANLEQVINDANSGANTDNKLINRAVNGVYPPGSVFKTITLSSAIENNPSVTGRIFNDTGKITFADGSTLNNYMYQAHGNIDLRTAYRVSSNVVFGTLAMELGNDKLKATAEKFGFNSRIPAEGVSISVSEFPTLESYEEGNIAQSGIGQGSVVVTPMQMAIMAATVANDGVLMQPKLVNKIVDKDGNLIREISNKVLKDNVISKDTAETVKSYMGYLVSNNIYRWPAFDGTNAGAKTGTADYKLPDGTDAVPHGWFITAAPLDDPKIAVAVIVENGENGAGTAAEIASKVVRMAVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL0</accession>
    <name>A0A386PGL0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-dependent thiol peroxidase</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_06625</name>
        <name evidence="6" type="ORF">EI377_01110</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34171">
        <property type="protein sequence ID" value="AYE34171"/>
        <property type="gene ID" value="CP523_06625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59538">
        <property type="protein sequence ID" value="QAS59538"/>
        <property type="gene ID" value="EI377_01110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="152" mass="17252" checksum="BAEDAB101595265A" modified="2018-12-05" version="1">MIELGKLAPDFTLIGSDGNEHSLSDYRGKKVILYFYPKDNTPGCSTEACDFRDNNNEINNLNAIVIGISKDSLSSHNKFIEKFHLPFILLSDEEKAVCALYDVIKEKNMYGKKVLGIERSTFIINEEGILIKEFRKVKVKGHVEAVIEELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL2</accession>
    <name>A0A386PGL2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02005</name>
        <name evidence="6" type="ORF">EI377_12525</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678894.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33319">
        <property type="protein sequence ID" value="AYE33319"/>
        <property type="gene ID" value="CP523_02005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61489">
        <property type="protein sequence ID" value="QAS61489"/>
        <property type="gene ID" value="EI377_12525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="91"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="478" mass="53302" checksum="FA00CC07AA73D53D" modified="2018-12-05" version="1">MSENNTSSEMKNTNKKKTSKKKKSLIILLSIIAVIAILSATVVGYYYKLRNQVYTKYTPEPTAGTDYKEVDGVTNVLLIGTDGRTLDEAARSDTIMIATLDNNNKVIKLTSIMRDTLVNIPGYGEGKINAAFAVGAVEGGAQGGAKLLIETIRETFKIDLKKYIIVNFWGFESIIDEIGGIEADIKDYEIEELNNYIGETTETESALIEKTGVQKLNGAQALSYSRIRKVGNGSYERTERQRKVLTQIATKLKDVSPLRYVSIANSIAKHVNTNIDIPEALDLAYTIYKLPDLKIEQLQMPQTELIVRDGEFKNLGWVLLIDKEQNSKVLHDFIFENKLPDSKEYDYYAIESLKSTYDAEHERYTSLYGTVSEENNDKNLDDDLPLIREPKPETNTNTNTDSGNNTDKNPPVTEQEKPSEKPPTTEGNKPQITPPTTEGNKPQITPPTTEENPSVSENEKPSSSGVENSRNAVTKVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN1</accession>
    <name>A0A386PGN1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12760</name>
        <name evidence="3" type="ORF">EI377_07635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678179.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35223">
        <property type="protein sequence ID" value="AYE35223"/>
        <property type="gene ID" value="CP523_12760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60618">
        <property type="protein sequence ID" value="QAS60618"/>
        <property type="gene ID" value="EI377_07635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12760"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="67" mass="7548" checksum="77E34AE8C988F872" modified="2018-12-05" version="1">MKIVVNLDVMMAKRKISLNELAERVGITNANLSILKNNKAKAIRFSTLEAICRELNCQPGDILEYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN2</accession>
    <name>A0A386PGN2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endonuclease III</fullName>
            <ecNumber evidence="6">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nth</name>
        <name evidence="8" type="ORF">CP523_04055</name>
        <name evidence="9" type="ORF">EI377_14575</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676913.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02775"/>
    <dbReference type="EnsemblBacteria" id="AYE33702">
        <property type="protein sequence ID" value="AYE33702"/>
        <property type="gene ID" value="CP523_04055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61857">
        <property type="protein sequence ID" value="QAS61857"/>
        <property type="gene ID" value="EI377_14575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="37"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="24663" checksum="1DFB7EB8C3F25DA4" modified="2018-12-05" version="1">MKQRTKTILQVLKEEYPDARCELNHESPFQLLVATILSAQTTDKKVNEVTETLFRDYRDLDAFLTLSIDELEARIKQIGLYRSKAKNIVMMCNQLKENFNGEVPKTMEEITSLAGAGRKTANVVLSNAFGVPSIAVDTHVFRVSNRLGLADSDNVLEVEKQLQKELPKKEWSDTHHLLIFHGRRCCTARNPKCDMCRLTKQCKYYKQNKKIATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS2</accession>
    <name>A0A386PGS2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07135</name>
        <name evidence="2" type="ORF">EI377_01880</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673711.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01042"/>
    <dbReference type="EnsemblBacteria" id="AYE34241">
        <property type="protein sequence ID" value="AYE34241"/>
        <property type="gene ID" value="CP523_07135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59646">
        <property type="protein sequence ID" value="QAS59646"/>
        <property type="gene ID" value="EI377_01880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07135"/>
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        <property type="component" value="Chromosome"/>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="Fido-like_dom_sf"/>
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        <property type="entry name" value="Fido_containing"/>
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    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="364" mass="43406" checksum="27DD18F949A27238" modified="2018-12-05" version="1">MDRQIINEFNRLYFSKKQLERRIYDKEELEYIWKIIEKERGENSVEILFKEIKNVKLWFNITDDIKQNIEFIKRVNESELLDYLPNRSKSKFLEANIKIDINSNLELNKTNLIDGNLDSKILSNIYDVLQNIESYGVQLNINSIKQIYLDIFKEDNAINEAQIKDILEFLEVKDRISPIIKIAIVYFYIIRFKPFSKYSDIMAGILTYMYLIRQGYGIFKYCSQSHIILGEQKKYYNAIENSRCSNGDITYFIRYYINSMKLAIDLLNKDVNCKYGKKIIKELLERNNVFLENRQIDFINKSISTNNKIVTIEDYKRESKVSYETARTDLNNLITLGFFKINKAGKKYEYYFNDIPTIIESFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT3</accession>
    <name>A0A386PGT3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class B sortase</fullName>
            <ecNumber evidence="3">3.4.22.71</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SrtB family sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srtB</name>
        <name evidence="2" type="ORF">CP523_04375</name>
        <name evidence="3" type="ORF">EI377_14910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.22.71" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676453.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33762">
        <property type="protein sequence ID" value="AYE33762"/>
        <property type="gene ID" value="CP523_04375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61919">
        <property type="protein sequence ID" value="QAS61919"/>
        <property type="gene ID" value="EI377_14910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
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    <dbReference type="Pfam" id="PF04203">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="228" mass="27023" checksum="B2AE115572A43C15" modified="2018-12-05" version="1">MKKIINLILISIVAFSSFKIVDKQIKYSKDIKVYSEINEIASDNSHMLDKSMLEVNNEYRFWIKVENTNIDYPVAQGKDNDYYINHDFNKNENISGAIFLDYRNNFINDLNTIVYGHHMRNETMFNNLVKFKDSNFFNENNKIKIIYDGKELEYKVFSVYVIDDKNNYLITNFNNNNEYNNYIKEIRDRSLYKNDVEVTDKDKIITLSTCSFEFEGARTVVHGKLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU3</accession>
    <name>A0A386PGU3_CLOSE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04425</name>
        <name evidence="2" type="ORF">EI377_14970</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676438.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33772">
        <property type="protein sequence ID" value="AYE33772"/>
        <property type="gene ID" value="CP523_04425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61930">
        <property type="protein sequence ID" value="QAS61930"/>
        <property type="gene ID" value="EI377_14970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="83" mass="9827" checksum="12F5A9D766CD076B" modified="2018-12-05" version="1">MTRNEKVINLYKETYADENLEELSIDEMEEALMEYYLATGFEINSVDELFENRDVNPDFDKEMEKKIQVVLKELAEKEAKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU9</accession>
    <name>A0A386PGU9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA_23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673764.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34271">
        <property type="protein sequence ID" value="AYE34271"/>
        <property type="gene ID" value="CP523_07310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13476">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="675" mass="78067" checksum="FDA121C966DB873E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH21</accession>
    <name>A0A386PH21_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04920</name>
        <name evidence="3" type="ORF">EI377_15420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675736.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33862">
        <property type="protein sequence ID" value="AYE33862"/>
        <property type="gene ID" value="CP523_04920"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62005"/>
        <property type="gene ID" value="EI377_15420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="17469" checksum="DEA10FF2D6F3A01A" modified="2018-12-05" version="1">MIKKRSLHVIFGGLTICILFCFNSIYCSMKCSSKLKLNWGIKLPDGYIEIYEKKKEKNFISVEGRYHIYEYDDISEVKEALEWRAGKNEDFEDSMLQSLEELNISKRYFPDFTGNYKYYVAEKTNLSKLYIIFAEKFKIINIVEKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH43</accession>
    <name>A0A386PH43_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02970</name>
        <name evidence="4" type="ORF">EI377_13485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679184.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00026"/>
    <dbReference type="EnsemblBacteria" id="AYE33499">
        <property type="protein sequence ID" value="AYE33499"/>
        <property type="gene ID" value="CP523_02970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61668">
        <property type="protein sequence ID" value="QAS61668"/>
        <property type="gene ID" value="EI377_13485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="41"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="245" mass="28234" checksum="F708077660C99FF4" modified="2018-12-05" version="1">MKNKLNIFIFSLVFILFISYNICPNALTIHNENDNTESEEKIVYLTFDDGPGGKTTLKILDTLKEENVPATFFIIGEQIQGQENTILRMKNEGHSIGLHSFSHEKAKLYRGNEGFLKEMLEDQESLYKVTGEKYHILRFPFGCNNNTYKLNQSMIDLLHENNLRVYDWNTDSGDGANPNSSPETIIKKACSNKNQNKVILLMHCSYMHKNSAKALPNIIKYYKSEGYKFKAIDENTPELYKIMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH66</accession>
    <name>A0A386PH66_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug resistance efflux transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03075</name>
        <name evidence="3" type="ORF">EI377_13575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01762"/>
    <dbReference type="EnsemblBacteria" id="AYE33519">
        <property type="protein sequence ID" value="AYE33519"/>
        <property type="gene ID" value="CP523_03075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61685">
        <property type="protein sequence ID" value="QAS61685"/>
        <property type="gene ID" value="EI377_13575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032713">
        <property type="entry name" value="EmrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13536">
        <property type="entry name" value="EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="34610" checksum="FA824385237EE7BE" modified="2018-12-05" version="1">MKKAILFGIGASLFFSLTFILNRQINIEGGSWIWSSSLRYIFMLPILFIIMILNNQLNPVIKDIFKRPIQWIIWSTVGFGLFYAPLSFASEYGASWLVAGTWQITIVAGAIMTPLFTKKIEVGKNVVYVRNSIPKKSLMMSSIILLGIFIMMFEEAKDISIGRTFLIIMPVVIAAFAYPLGNRKMMEVCKNEFTTFQRVFGMTLCSIPFWLFISIWGTIIVGLPSKGQVVQSFIVAMFSGVIATILFFKATDMVSNNAHKIAIIESTQAGEVIFTLLGGIFILNDKIPTTIGIVGIILVVIGMVLNSIIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK8</accession>
    <name>A0A386PHK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1836 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07990</name>
        <name evidence="2" type="ORF">EI377_02750</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675920.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00713"/>
    <dbReference type="EnsemblBacteria" id="AYE34368">
        <property type="protein sequence ID" value="AYE34368"/>
        <property type="gene ID" value="CP523_07990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59774">
        <property type="protein sequence ID" value="QAS59774"/>
        <property type="gene ID" value="EI377_02750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014975">
        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40056">
        <property type="entry name" value="PTHR40056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="193" mass="22651" checksum="CCBD0B55D8A0E2B9" modified="2018-12-05" version="1">MDLNILKEKFQDLKLENQISLEEIPDIDLYMDQVIQLFENKLGDTKRSEDDKTLTKTMINNYAKGKLLMSIKNKRYSKEHIILMSMIYNLKGTLSINDIKSSLDKIVSSLDEEGNYPLKNLYKNYLEQYNNDLIDAEISISEKNSIIDEKLSKDEEISGEFEKNFLLLCSLVNMSNMYRRMSEKLIDDYFNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL1</accession>
    <name>A0A386PHL1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10870</name>
        <name evidence="5" type="ORF">EI377_05665</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
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                <person name="Sriranganathan N."/>
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    <sequence length="580" mass="62417" checksum="64CD5A0CACA6CB37" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
    <sequence length="280" mass="30636" checksum="1B108506FCBE3276" modified="2018-12-05" version="1">MKMKLKEFSIITLGVLLVAVALEYFFIPNKIAAGGLTGLAIVINHYIPFISTGPLVLIMDLILYAVGFMFLGRNFGVKTIYASLSLSIIMSFIETFLNPQAITNDLIIATIFGTIITALGMSLVFHMDSGTGGTDTIAKILNKFFHIDIGKSLLIVDFIVTSLGAITFGINIGLYALLAVIINGIAIDNVIAGFHLCKEVTIISTENQKISRFIMEELERGCTFLKGVGGFTGKDTEVLYAVLERKEFIKLKQYITEVDKKAFISVGEVHEVMGEGFKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS8</accession>
    <name>A0A386PHS8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08355</name>
        <name evidence="4" type="ORF">EI377_03100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674772.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01612"/>
    <dbReference type="EnsemblBacteria" id="AYE34438">
        <property type="protein sequence ID" value="AYE34438"/>
        <property type="gene ID" value="CP523_08355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59841">
        <property type="protein sequence ID" value="QAS59841"/>
        <property type="gene ID" value="EI377_03100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="2">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="151" mass="17596" checksum="A226EDBF6E2F806E" modified="2018-12-05" version="1">MNNLSFSNIEDIKAEEQRIHEEYKRKLAELKKIQKEKESVGQVFTKGLLPIYVLHILTLGPINGNEIAHKIGENTKGLWVPSTGGIYPLLKKLEKEGYVIGKWDDPHKKFQKFYSLTPKGLEEYNHRKSLLKPKIEESLKVFKIIYKDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV6</accession>
    <name>A0A386PHV6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbgT family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Aminobenzoyl-glutamate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06730</name>
        <name evidence="3" type="ORF">EI377_01205</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679142.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01566"/>
    <dbReference type="EnsemblBacteria" id="AYE34186">
        <property type="protein sequence ID" value="AYE34186"/>
        <property type="gene ID" value="CP523_06730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59550">
        <property type="protein sequence ID" value="QAS59550"/>
        <property type="gene ID" value="EI377_01205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015558">
        <property type="term" value="F:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902604">
        <property type="term" value="P:p-aminobenzoyl-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004697">
        <property type="entry name" value="AbgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30282">
        <property type="entry name" value="PTHR30282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03806">
        <property type="entry name" value="ABG_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="515" mass="54765" checksum="29ED025B8DE8500F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY0</accession>
    <name>A0A386PHY0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_06790</name>
        <name evidence="12" type="ORF">EI377_01265</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01457"/>
    <dbReference type="EnsemblBacteria" id="AYE34192">
        <property type="protein sequence ID" value="AYE34192"/>
        <property type="gene ID" value="CP523_06790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59556">
        <property type="protein sequence ID" value="QAS59556"/>
        <property type="gene ID" value="EI377_01265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="811" mass="93134" checksum="7336DCDA8CF2C22B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY1</accession>
    <name>A0A386PHY1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15500</name>
        <name evidence="2" type="ORF">EI377_10205</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678713.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35725">
        <property type="protein sequence ID" value="AYE35725"/>
        <property type="gene ID" value="CP523_15500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61064">
        <property type="protein sequence ID" value="QAS61064"/>
        <property type="gene ID" value="EI377_10205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="194" mass="22816" checksum="C88B2AE9D901645F" modified="2018-12-05" version="1">MFKFDLMNIFEGLIRNYIKFNLNKDSDKFSILKKEIDYLVSVGEVLGYSSIVTGIDKDNEFINNKIEIIWHDYDDKKAMPKDEVFYYSIEEDLVNDIKSLDNLFNNMNKETNNTSFMQVIEVVSKERILYLNRYMQMAKGLSGKDSLIVYRIKNILEGKTYLYAYLFNGNKIVKERVAVSYTDVFGFLKAKFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI91</accession>
    <name>A0A386PI91_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05005</name>
        <name evidence="4" type="ORF">EI377_15520</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01792"/>
    <dbReference type="EnsemblBacteria" id="AYE33879">
        <property type="protein sequence ID" value="AYE33879"/>
        <property type="gene ID" value="CP523_05005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62024">
        <property type="protein sequence ID" value="QAS62024"/>
        <property type="gene ID" value="EI377_15520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="843" mass="94390" checksum="F2510DB3F9B80093" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI93</accession>
    <name>A0A386PI93_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Peptidase M20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11935</name>
        <name evidence="3" type="ORF">EI377_06755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02945"/>
    <dbReference type="EnsemblBacteria" id="AYE35067">
        <property type="protein sequence ID" value="AYE35067"/>
        <property type="gene ID" value="CP523_11935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60460">
        <property type="protein sequence ID" value="QAS60460"/>
        <property type="gene ID" value="EI377_06755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="190"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="401" mass="44836" checksum="0B26023B907BABC1" modified="2018-12-05" version="1">MDYFKEQVLSIKNELISIRRDIHENPELGMEEYRTSSKIKEFLKAEGIDFREVSKTGVCGIIKGNKKGENLKTIALRADIDALPILDKKTCSYASKVKGKMHGCGHDAHTTILLGCAKILNRNRHLFNGNVKFLFEPAEETVGGARFMIDEGVLENPRVDAILGLHVEETLECGKVMVKKGVVNAASNPFKILIKGSGGHGAYPHTTVDPIVIASTVIMSLQTIVSREIDANHQAVVTIGSIHGGTAQNVIPEEVIIKGIIRTMYKEDREYIKRRIQEIVEGICNSSRSTCNIEIEDSYPSLWNNDYMVNLFQDTSNKVLGEENIVVQKNPKMGVESFAYFANERPSVFYFLGSLNKEKNIIYPAHSSLFDIDEDCLTIGVTMQCELVLQYLTRSEFNINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA7</accession>
    <name>A0A386PIA7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="6" type="ORF">CP523_06150</name>
        <name evidence="7" type="ORF">EI377_00630</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675167.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01931"/>
    <dbReference type="EnsemblBacteria" id="AYE35833">
        <property type="protein sequence ID" value="AYE35833"/>
        <property type="gene ID" value="CP523_06150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62141">
        <property type="protein sequence ID" value="QAS62141"/>
        <property type="gene ID" value="EI377_00630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06150"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine binding" evidence="3">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="32871" checksum="C851B4E4FA9A4948" modified="2018-12-05" version="1">MELWYTENQTENVNFSMKVKRHLYSNQSPFQKIDVLDTYEFGRVLVIDNWTMVTEKDEFIYHEMITHVAMATNPEIKNVLVIGAGDGGTVRELTRYETIENIDMVEIDEDVVKASKEFLPFTANKLDDKRVNLLFKDGIKFIKDKENLYDLIIVDSTDPIGPGEGLFTTEFYSDCFKALTEKGILINQCESPYYPNNQREMIRSFNKLKSLFNICEAYQYHMPTYPSGHWMFCFASKELHPIKDFDAERWTSLGLETKYYNTDLHVGSFMLPNYVKELLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF6</accession>
    <name>A0A386PIF6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Class D sortase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sortase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09500</name>
        <name evidence="4" type="ORF">EI377_04245</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34638">
        <property type="protein sequence ID" value="AYE34638"/>
        <property type="gene ID" value="CP523_09500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60037">
        <property type="protein sequence ID" value="QAS60037"/>
        <property type="gene ID" value="EI377_04245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06166">
        <property type="entry name" value="Sortase_D_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042000">
        <property type="entry name" value="Sortase_D_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01076">
        <property type="entry name" value="sortase_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="195" mass="21622" checksum="35DBD4577B822A1C" modified="2018-12-05" version="1">MKEKFRRGIGLILICVGIFLISFTVYNKIQTNKKQQQLQQILQDVIKDEGSEGKENEPTTIDGYKPVALVEIPSINLSQGLVEGITDDVLQYYLGHFEGTAEPGEKGNFAVAGHRVSNYSEAFINLYKVKKGDDIIVKSKGKEFIYKVDDGFVVAPDRVDVLENTKDATITLVTCTVGAKERYIVKGTLVSSKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG9</accession>
    <name>A0A386PIG9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_05400</name>
        <name evidence="7" type="ORF">EI377_15960</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677977.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02589"/>
    <dbReference type="EnsemblBacteria" id="AYE33949">
        <property type="protein sequence ID" value="AYE33949"/>
        <property type="gene ID" value="CP523_05400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62100">
        <property type="protein sequence ID" value="QAS62100"/>
        <property type="gene ID" value="EI377_15960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="312" mass="35266" checksum="03A60CE430CE5DF8" modified="2018-12-05" version="1">MYPIRFENLYYEKIWGGRDLESFRDNLPDGNIGESWDIACHPNGTGIVENGEFKGIKFDTLIKEQGHNLVGTKVSLEKLPLLIKLINSGEKLSVQVHPGDEYAAKYEGDYGKTEAWYVIDAKPGASLIVGTKDCTKEEFKAAIENDEVEKYLNKIEVKKGDCFLINSGLVHAICEGTIIAEIQQNSDVTYRVYDYGRPREIHVKKALDVINFDLQCENLQGELKSFDGYKKALLCENEYFGIEKMVIESSLKEESDKERFFMFTCVEGEGTIEGEGFNEKIKMGDSYLIPATLGNYEIKGKLTVLKSYPVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ4</accession>
    <name>A0A386PIJ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11425</name>
        <name evidence="4" type="ORF">EI377_06240</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673281.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02842"/>
    <dbReference type="EnsemblBacteria" id="AYE34974">
        <property type="protein sequence ID" value="AYE34974"/>
        <property type="gene ID" value="CP523_11425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60367">
        <property type="protein sequence ID" value="QAS60367"/>
        <property type="gene ID" value="EI377_06240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="471" mass="53462" checksum="08447C0B0136CB9C" modified="2018-12-05" version="1">MNLSSNLYENVSKLRQGLNLGKTFDVIERIIDVHNTKFYLYYLDGFVKDTNMEYVRRDMYNLKKEDFEGIKTATDLIEKALSSIETSTEKDIEKIISAVLSGQTALLGPNYTEAVLLDFRTYPSRGVEEPEKEKVLRGSHDGFVETIVFNTALIRRRIRSSELTFEMHSIGSVSKTDVVVGYLGNKVDNKKLEKIKELIDELNIKSLTLGDQSFVEVVNSKSWLNPFPKVRYTERPDVAAAQIMEGSIVILIDNTPSALILPSNIFDFLQSIDDYYMPVLTGNYLKFVRFIVLFANLFLTPLYVLLTDNPSWISGNFQFLLPKDPYILPIFIQFLIAEIAIDGIKLASLDTPSTLGTSLSIIGGLILGDYTVQTGWFTPQTILYMAIVALSSFTQPSIELGFAFKFIRIILLLLTGIFGTWGFILGIIINFIIIASTKTVLGDPYLYPLIPFKWRELKKLLFRWKKQIAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ6</accession>
    <name>A0A386PIJ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_08425</name>
        <name evidence="10" type="ORF">EI377_03170</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01626"/>
    <dbReference type="EnsemblBacteria" id="AYE34452">
        <property type="protein sequence ID" value="AYE34452"/>
        <property type="gene ID" value="CP523_08425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59855">
        <property type="protein sequence ID" value="QAS59855"/>
        <property type="gene ID" value="EI377_03170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="420" mass="45714" checksum="637641BB6F18340B" modified="2018-12-05" version="1">MINKNFIIIVIGQIISLFGNAIQRFSMSLYLLEFTGSTAAFANILAISTIPYIIFAPIAGRIVDNVNRKKIMVYLDLFCTILIGAYAFILLNGSDNELIVAVVMFILSICSTLYGPAVTSSIPQIVNEDKLTTANGIINQVGSVVNFVGPILAGVLYGLLGIKLIVIINAISFLVSAIMELFLDIPDVRKKEEICCNNKENLLSVDFLRKSFVDMKNSFGYLKKEKKVVLGIIVSYALCNIFLVPILSIVAPYFINILLGLPSQIYGIVEGICVIGMILGGILISIKPNMFSMKKIHYTYFPMILGVMLMSILGFININSYALAGIFAISGMAIMLSLALSNILTLTFIQKEVPADMLGRVSAFSTAVATISVAPGQLLFGQVIDSGIPIGLILGITTIINIGLILFVKWNVRELDIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT0</accession>
    <name>A0A386PIT0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription antiterminator LicT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01410"/>
    <dbReference type="EnsemblBacteria" id="AYE34788">
        <property type="protein sequence ID" value="AYE34788"/>
        <property type="gene ID" value="CP523_10450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001550">
        <property type="entry name" value="Transcrpt_antitermin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00654">
        <property type="entry name" value="PRD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="66"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="172"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="282" mass="32969" checksum="522EA61E9BCA31BB" modified="2018-12-05" version="1">MIVEKILNNNVVVSIDPKTKKEVILMGCGIAFRKKVGQEVDESKIEKVFMVDDKRLGNKLKKLINQIPDGVFELSHEIICHASKELDRKLDKQICISLSDHIAFALKRYRNKIQIKNDLLDEIRRIHKEEYKVAHWAVDYLNKKLKINLPEDEAGFIALHLVNASYNETAKESLIATNVIKGVLNIIRYYYSVEFNEDDLNYDRLLTHLKYFAKRVITNNQHKESDSTFIELASQTYPEAFDCALKIRYYIENNYDYEVNNDEIVYLTMHIHRVISVLKDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ06</accession>
    <name>A0A386PJ06_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12660</name>
        <name evidence="6" type="ORF">EI377_07560</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675212.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01979"/>
    <dbReference type="EnsemblBacteria" id="AYE35204">
        <property type="protein sequence ID" value="AYE35204"/>
        <property type="gene ID" value="CP523_12660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60606">
        <property type="protein sequence ID" value="QAS60606"/>
        <property type="gene ID" value="EI377_07560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="27739" checksum="43F552FF4C7A5302" modified="2018-12-05" version="1">MSFLTFKNIFKVYGEGEGQVYALNDISFNINKGEMLAIMGPSGSGKSTLLNIIGCLDNPSKGEYIINNKISNKLKEKQLSKLRNELFGFVVQFFALIEDLNIEKNISIPLEYSKKRYSKKEKKEKIESLAERLKIKEKLKRYPKELSGGQCQRAAIARALINNPDIILADEPTGALDKKTGEEVVNILRELANKEKTIIIVTHDINVAMKCDRVLILEDGKIKSERMNYEEENNIIYNNSNFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ22</accession>
    <name>A0A386PJ22_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06510</name>
        <name evidence="5" type="ORF">EI377_00995</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677451.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02179"/>
    <dbReference type="EnsemblBacteria" id="AYE34149">
        <property type="protein sequence ID" value="AYE34149"/>
        <property type="gene ID" value="CP523_06510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59517">
        <property type="protein sequence ID" value="QAS59517"/>
        <property type="gene ID" value="EI377_00995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="117" mass="12993" checksum="41A1D355D2F470B0" modified="2018-12-05" version="1">MTTMVVKRGDIFYADLSPVIGSEQGGIRPVIIVQNDIGNKYSPTVIVAAITSQINKAKLPTHVEISSEEYGLNRDSVVLLEQIRTLDKRRLKEKIGHMTDVDMKKVNKSLLISLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ36</accession>
    <name>A0A386PJ36_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="12">DHBP synthase</shortName>
                <ecNumber evidence="12">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="12">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">ribBA</name>
        <name evidence="14" type="ORF">CP523_14090</name>
        <name evidence="15" type="ORF">EI377_08995</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="12"/>
    <dbReference type="EC" id="3.5.4.25" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678462.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03094"/>
    <dbReference type="EnsemblBacteria" id="AYE35467">
        <property type="protein sequence ID" value="AYE35467"/>
        <property type="gene ID" value="CP523_14090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62190">
        <property type="protein sequence ID" value="QAS62190"/>
        <property type="gene ID" value="EI377_08995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14090"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="13">
        <location>
            <begin position="208"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="12">
        <location>
            <begin position="202"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS62190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="44463" checksum="7A0A0F7980B31E62" modified="2018-12-05" version="1">MSKFMTIEKAIKNIKLGKMIIVIDDEDRENEGDLVMAGEMVTGADINFMATHGKGLICMPISQEIASNLELTPMVENNTDNHETAFTVSIDYKETSTGISAFERATTIQNIVKNNSKPNDFRRPGHIFPLIGKQGGVLKRAGHTEASLDLAKLAGLKEVGVICEIIKDDGTMARTSELLEFSKEHGIGVITIKDLIAYRSKREILVEKMVETKMPTKYGEFLAIGFVNRLNGEHHVALVKGDIKENDSVLLRVHSECLTGDVFGSKRCDCGEQFDRAMKQISNEGSGILLYMRQEGRGIGLINKLKAYKLQDEGFDTVEANLKLGFPEDLRDYGIGAQILKLLGVKKIRLMTNNPKKISGLEGYGLNIVERVPIEIESNKDNIFYLKTKKEKMEHLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ38</accession>
    <name>A0A386PJ38_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Aminopyrimidine aminohydrolase</fullName>
            <ecNumber evidence="6 8">3.5.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tenA</name>
        <name evidence="10" type="ORF">CP523_12875</name>
        <name evidence="11" type="ORF">EI377_07755</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:31799"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:63416"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17509"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="EC" id="3.5.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the TenA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.2" evidence="6 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678236.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03036"/>
    <dbReference type="EnsemblBacteria" id="AYE35244">
        <property type="protein sequence ID" value="AYE35244"/>
        <property type="gene ID" value="CP523_12875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60639">
        <property type="protein sequence ID" value="QAS60639"/>
        <property type="gene ID" value="EI377_07755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12875"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="9">
        <location>
            <begin position="12"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="219" mass="26109" checksum="FBB6D935E51684A2" modified="2018-12-05" version="1">MSFTDYLFKENKKLWDEILQKPFVKEMGEGTLDKNKFRDYLIQDYLYLKEYSKIFCMGVIKATTMGEMKFYYNSIKGTMEDETAVHIKYLKGFGMSPEDTEKCDVKLANESYTSYMKGIALTGNLKEIAMAIMPCTWSYQYIGKCMKETYKDTLEGNFYKPWIDLYNSKEFQDFTKEWIDYINEICKDVTSEDEKKKLLEIFTKSTIYEMKFWDMAYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ47</accession>
    <name>A0A386PJ47_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02740"/>
    <dbReference type="EnsemblBacteria" id="AYE34626">
        <property type="protein sequence ID" value="AYE34626"/>
        <property type="gene ID" value="CP523_09405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="277" mass="31749" checksum="BC4F8D7316912185" modified="2018-12-05" version="1">MDLYVSDLDGTLLNSDKEISNFSKDKLNRLINKGLQFTVATARTPATAVDILKGIHITLPVAMMNGVLIYDINENKYIDIKKIKDSSVIKVLDIFKEHKKNCFVYAIKDNHLWVYHKDFTCSMEENFYDERCNKPLKTFIKVADYYKASEGSEIINFIIFDKLEIVKPIYDKLKIIEGITVDYYRDIYGDGYFLEAYSSEASKANAINLLSNYVDSDRLITFGDNVNDIPMFKISDECYATENATESLKKIATAVISSNNDDGVAKFILEKNKRFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ77</accession>
    <name>A0A386PJ77_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ethanolamine utilization protein EutH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eutH</name>
        <name evidence="2" type="ORF">CP523_09970</name>
        <name evidence="3" type="ORF">EI377_04755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676550.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00323"/>
    <dbReference type="EnsemblBacteria" id="AYE34702">
        <property type="protein sequence ID" value="AYE34702"/>
        <property type="gene ID" value="CP523_09970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60103">
        <property type="protein sequence ID" value="QAS60103"/>
        <property type="gene ID" value="EI377_04755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034228">
        <property type="term" value="F:ethanolamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007441">
        <property type="entry name" value="EutH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40089">
        <property type="entry name" value="PTHR40089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04346">
        <property type="entry name" value="EutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019466">
        <property type="entry name" value="EutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="359" mass="37961" checksum="D500E004A922457D" modified="2018-12-05" version="1">MEKIVLYIVASFFVIGCLDYILGNKLKLGVNFEAGINNMGPLALSMIGILSITPIISDIIIRYIAPLTSSIGIDSSIISSSFIAIDMGAFNIARNVGGSNELVYFSGVLIASILGCTISFTLPLALGMIKDKNIHALCKGILCGIVTLPIGLFIGGMMLGLPIRIILINLMPIIIFSVVVSIGLSIGIDKVIIIFSYMGKSIVILGFLGLGIQGFTSISGIIIFKSLMPIEEALITVGKIAIFLGGAYVMLEIVKKILSTQINKITEKIGVNASSVAALIGSLASAIVVFSTFEELDERGKVICSAFSVAGAYVLGGQLGYVATEAREIVLIYIITKLICGVLAIILAFLITKEVNTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJD8</accession>
    <name>A0A386PJD8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">CP523_10100</name>
        <name evidence="9" type="ORF">EI377_04900</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676590.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00349"/>
    <dbReference type="EnsemblBacteria" id="AYE34726">
        <property type="protein sequence ID" value="AYE34726"/>
        <property type="gene ID" value="CP523_10100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60127">
        <property type="protein sequence ID" value="QAS60127"/>
        <property type="gene ID" value="EI377_04900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="68" mass="7677" checksum="82497D6C88C1F3A4" modified="2018-12-05" version="1">MREGIHPKYNNEAVVKCACGNTFTTGSVKDELKVEICSKCHPFFTGKQKIVDVGGRVDKFNKRFNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI3</accession>
    <name>A0A386PJI3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="10" type="ORF">CP523_15065</name>
        <name evidence="11" type="ORF">EI377_10020</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676017.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01271"/>
    <dbReference type="EnsemblBacteria" id="AYE35647">
        <property type="protein sequence ID" value="AYE35647"/>
        <property type="gene ID" value="CP523_15065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61034">
        <property type="protein sequence ID" value="QAS61034"/>
        <property type="gene ID" value="EI377_10020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="9">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="8">
        <location>
            <begin position="124"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="45220" checksum="3F44BAFDF3001C0F" modified="2018-12-05" version="1">MKIKTLSVSEVNNYIKKTLDNDFILNNLSVKGEISNLKYHTSGHIYFSLKDSNGKLNCIMFRNRAIDLHFELEEGMEVTVKCRCSIYPGNGSLQLYIEDIEKDGVGELYIKFEKLKEKLLKEGYFDEEYKKPMPSMPLRVGVITSETGAVIKDIINVTRRRNKMIDIVLFPANVQGIDAYKSIIKGLKFFNNKKNVDVIILGRGGGSLEELWNFNEEELAIEIFKSNIPVVSAVGHEVDYTISDFVSDLRAATPSQAAEIVVPIESEIKNSLNNIKNRLDELIEINILQEKNRMKNLSKILNLNSPISRVANSYLEVDTLKNRLNQSIVNKINNEKIRIESLNNILKAHNPINVLQKGYSIVEDNEGNILSSKDDLMEEKEISMLFKNGSVTGIFAPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ2</accession>
    <name>A0A386PJJ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">spo0A</name>
        <name evidence="12" type="ORF">CP523_15125</name>
        <name evidence="13" type="ORF">EI377_10080</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8 9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679010.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00103"/>
    <dbReference type="EnsemblBacteria" id="AYE35657">
        <property type="protein sequence ID" value="AYE35657"/>
        <property type="gene ID" value="CP523_15125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61043">
        <property type="protein sequence ID" value="QAS61043"/>
        <property type="gene ID" value="EI377_10080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012052">
        <property type="entry name" value="Spore_0_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002937">
        <property type="entry name" value="Res_reg_Spo0A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02875">
        <property type="entry name" value="spore_0_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 8" id="KW-0749">Sporulation</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="29978" checksum="788212834B638E53" modified="2018-12-05" version="1">MNGTKISVLIADDNKEFCSILNDYLLNQRDIVVTGVAKDGREALALIEEKKPDLVVLDIIMPHLDGLGVLEKLNTMNLEKMPRIIVLSAVGQDKITQRAITLGADYYVVKPFDMDVFTKRIREMFNGVPTEAVRRATTVVETEAPMQAKGPVDLETEITNIIHEIGVPAHIKGYMYLREAITMVVNDMELLSAVTKELYPSIAKKYNTTASRVERAIRHAIEVAWGRGQIEAINKLFGYTIHNDKGKPTNSEFIAIIADKLRLKNKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP4</accession>
    <name>A0A386PJP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aminopeptidase P family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08260</name>
        <name evidence="6" type="ORF">EI377_03010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674727.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01594"/>
    <dbReference type="EnsemblBacteria" id="AYE34419">
        <property type="protein sequence ID" value="AYE34419"/>
        <property type="gene ID" value="CP523_08260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59824">
        <property type="protein sequence ID" value="QAS59824"/>
        <property type="gene ID" value="EI377_03010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="313"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="528"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="588" mass="67094" checksum="2863549AF01678D3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJQ0</accession>
    <name>A0A386PJQ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nanE</name>
        <name evidence="7" type="ORF">CP523_10765</name>
        <name evidence="8" type="ORF">EI377_05550</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674098.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01349"/>
    <dbReference type="EnsemblBacteria" id="AYE34846">
        <property type="protein sequence ID" value="AYE34846"/>
        <property type="gene ID" value="CP523_10765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60240">
        <property type="protein sequence ID" value="QAS60240"/>
        <property type="gene ID" value="EI377_05550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10765"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="25484" checksum="DD8CC9513AA8DF13" modified="2018-12-05" version="1">MRKEEMINKIKSGLIVSCQALEGEPLYIENDSIMPLMARAAKKAGACAIRTNGVRDVIGIKKETQLPVIGIIKKSYEGYEQYITVTMDEIDKLVEAGADIIALDCTLRERKDGKTVAEHIKSIKEKYPDILLMADISNLEEGINAWKSGVDLVGTTLSGYTDYTPKLDGPDYELVKSLVEAIDIPVIAEGRVHYPNQAVEMLKLGATAVVVGGAITRPLEITSRFMDAINKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS5</accession>
    <name>A0A386PJS5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">moaC</name>
        <name evidence="7" type="ORF">CP523_15670</name>
        <name evidence="8" type="ORF">EI377_10385</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678610.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00557"/>
    <dbReference type="EnsemblBacteria" id="AYE35757">
        <property type="protein sequence ID" value="AYE35757"/>
        <property type="gene ID" value="CP523_15670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61096">
        <property type="protein sequence ID" value="QAS61096"/>
        <property type="gene ID" value="EI377_10385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15670"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="158" mass="17229" checksum="66DC02381433F889" modified="2018-12-05" version="1">MKNNLTHFDESGNARMVDVSDKDKTKRVAIAVSKIKTSKETLNLIEQGKIGKGDVLGVARVAGIMASKQTSNLIPMCHPLMISSCDIEFKINKDESCIDIKASVKIFDKTGVEMEALTAAMVSALTIYDMCKAVDKRMVIEGTHLLKKTGGKSGEFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU6</accession>
    <name>A0A386PJU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12785</name>
        <name evidence="6" type="ORF">EI377_07660</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678184.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02794"/>
    <dbReference type="EnsemblBacteria" id="AYE35228">
        <property type="protein sequence ID" value="AYE35228"/>
        <property type="gene ID" value="CP523_12785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60623">
        <property type="protein sequence ID" value="QAS60623"/>
        <property type="gene ID" value="EI377_07660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="376" mass="39393" checksum="59453A3BEE98DC9A" modified="2018-12-05" version="1">MKFILAPDSFKESMTSKEACDAMELGIKKVIKDAECIKVPMADGGEGTVEALVEATNGTIHKVKVTAPLGNEVEAIFGVLGNKTTAVIEMASASGIHLVKREERNPLITTTYGTGELIRAALDLGVKHIVIGIGGSATNDGGAGMIQALGGKILDKDGNQIAFGGGELSKVEKIDLTELDKRIKEVTIEVACDVTNPLVGETGASAIFGPQKGATEEMVKILDKNLSNYAKVIKKELGKDVANVEGAGAAGGLGAALLAFLDAKLEKGIELVIKHTELKEKVKGAAFVFTGEGAIDNQTIYGKTPMGVAKTAKEEGIKTIAFAGKVSEGVENLYPIGIESIFSIMQGVDTLDDALKNGRENLAKTVENVVRLISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK01</accession>
    <name>A0A386PK01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2975 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11520</name>
        <name evidence="3" type="ORF">EI377_06335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673323.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34992">
        <property type="protein sequence ID" value="AYE34992"/>
        <property type="gene ID" value="CP523_11520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60385">
        <property type="protein sequence ID" value="QAS60385"/>
        <property type="gene ID" value="EI377_06335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="159" mass="18328" checksum="DB2C2B1669CB48C7" modified="2018-12-05" version="1">MELTKWINPVINLLLLLVGFMIIGGVFSIIFLLDFSDSSKIKDLTIIISNTIMYILIFLPIFQLKKIIKSISENKIFTLENVKRFRFISYPIFLIAFLSCFGGYSNIEIMSIKGFSIKGYTLIILILALFALIMSHIFHEAMLVKTESEKLKEENKYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK18</accession>
    <name>A0A386PK18_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail tape measure protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679044.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
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    <dbReference type="STRING" id="1504.GCA_900092375_01950"/>
    <dbReference type="EnsemblBacteria" id="AYE35318">
        <property type="protein sequence ID" value="AYE35318"/>
        <property type="gene ID" value="CP523_13275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMin_Tail" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="718" mass="75844" checksum="EF09E503E200CB4E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKJ7</accession>
    <name>A0A386PKJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03475</name>
        <name evidence="8" type="ORF">EI377_14000</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02246"/>
    <dbReference type="EnsemblBacteria" id="AYE35811">
        <property type="protein sequence ID" value="AYE35811"/>
        <property type="gene ID" value="CP523_03475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62229">
        <property type="protein sequence ID" value="QAS62229"/>
        <property type="gene ID" value="EI377_14000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
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            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="33076" checksum="CAFC0B21F927E7DC" modified="2018-12-05" version="1">MKKHSKLAKKEWLSAYIFLLPAAIFFLSFVIIPMVGGIVISFFNYTPRSSEFIGLKNYVQIFNDPVFRKSLWNTLFLVIGNVPIVLVFSMFVAVTIYKRSSKVRSFFRSVFYLPAIASVVSITVVWGWIFHPNYGILNYVLSFFGVEAQSWLGNPSIAKWAILMVLVTLSVGQPIVLYMASLGNIPKDYLEAAEIDGASARQVFWNITWPLLKPTTLYIVIITTINSFQCFSIIQLLTAGGPNYATTTIMYQVYERSFTLGQYGLASSMGVVLAIIVMAISVVQYKYLGSDVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKL2</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">CP523_12620</name>
        <name evidence="8" type="ORF">EI377_07525</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01987"/>
    <dbReference type="EnsemblBacteria" id="AYE35196">
        <property type="protein sequence ID" value="AYE35196"/>
        <property type="gene ID" value="CP523_12620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60599">
        <property type="protein sequence ID" value="QAS60599"/>
        <property type="gene ID" value="EI377_07525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
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    </dbReference>
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        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
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        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
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    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
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        <location>
            <position position="12"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="671" mass="77148" checksum="3C46104D19090EB6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKL3</accession>
    <name>A0A386PKL3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00434"/>
    <dbReference type="EnsemblBacteria" id="AYE35814">
        <property type="protein sequence ID" value="AYE35814"/>
        <property type="gene ID" value="CP523_04210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="1">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="178" mass="20814" checksum="09B6193F630A2D3F" modified="2018-12-05" version="1">MGGGLYFLHYSKASKGKVGKEIDSYKNVPVYYNGLNYTKTYGESYSEDGYYYGYKWQCVEYIKRFYKEAKNHKMPDVYGNAKDFFDNSVPQGELNKSRDLIQYRNEGNVKPEPDDLIVFSGNIFGHVAIVTEVTEDYVEVIQQNVYSKTREKYDLTEKDGKYIVGKYKKIVGWLRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKV4</accession>
    <name>A0A386PKV4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14970</name>
        <name evidence="3" type="ORF">EI377_09925</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676054.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35628">
        <property type="protein sequence ID" value="AYE35628"/>
        <property type="gene ID" value="CP523_14970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61015">
        <property type="protein sequence ID" value="QAS61015"/>
        <property type="gene ID" value="EI377_09925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="150" mass="17649" checksum="171B238BDDDD950D" modified="2018-12-05" version="1">MRKKGSLIIETLVAMMFLIISGSIVLSSVISAEKSLKIRKVKEELSRVSYNIMNEIKYNYTLEEINEILDKGSFKLKYYENFMLDLLKINLIDMEIGDEIEITRVNDNKEDNINKDVSFLYKYRVNITVDVGGFEVNENREFYKSFWMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL85</accession>
    <name>A0A386PL85_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03325</name>
        <name evidence="8" type="ORF">EI377_13840</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02119"/>
    <dbReference type="EnsemblBacteria" id="AYE35808">
        <property type="protein sequence ID" value="AYE35808"/>
        <property type="gene ID" value="CP523_03325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62226">
        <property type="protein sequence ID" value="QAS62226"/>
        <property type="gene ID" value="EI377_13840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="61"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="342"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="549" mass="60460" checksum="83FA3E9AFA27248A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLC7</accession>
    <name>A0A386PLC7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ORF">CP523_14580</name>
        <name evidence="8" type="ORF">EI377_09550</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021875897.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00196"/>
    <dbReference type="EnsemblBacteria" id="AYE35556">
        <property type="protein sequence ID" value="AYE35556"/>
        <property type="gene ID" value="CP523_14580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60943">
        <property type="protein sequence ID" value="QAS60943"/>
        <property type="gene ID" value="EI377_09550"/>
    </dbReference>
    <dbReference type="GeneID" id="66301908"/>
    <dbReference type="KEGG" id="csep:CP523_14580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="13593" checksum="69B592601AA9146E" modified="2018-12-05" version="1">MARVKRAVNARKNHKKVLKLAKGYYGGKSRLFKTANESVIRALRNAYVGRRLKKRDFRRLWIARINAATRMNGLSYSKFINGIKLAGIDMNRKMLSEIAINDPKAFADLVEVAKSQLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLD9</accession>
    <name>A0A386PLD9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent aminotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12740</name>
        <name evidence="5" type="ORF">EI377_07615</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE35219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675169.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01963"/>
    <dbReference type="EnsemblBacteria" id="AYE35219">
        <property type="protein sequence ID" value="AYE35219"/>
        <property type="gene ID" value="CP523_12740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60615">
        <property type="protein sequence ID" value="QAS60615"/>
        <property type="gene ID" value="EI377_07615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="466" mass="53870" checksum="8D4AD089B10BCB62" modified="2018-12-05" version="1">MDVITINLSNNDNIPLYEQLYNYIKNEIQQGKIVSNTKLPSKRKLAKHLQISLNTIESAYEQLMAEGYIYSKPKKGFFVSELDGVIQIKNSKAYINIDSNKEKVNYKYEFLSSRVDLDSFPYEVWRKISKDIIDIESREFLQIGHSQGELNLREAIAKYLYFSRGVACHPNQIVIGAGTEYLLQVLINIIGRDNSYGMENPGYFKIKRILNTYGIWANGIELDNYGVNIEKLNESSVNIMHITPSHQFPLGIVMPIKRRMQLLTWANEGENRYIIEDDYDSEFRFGGKPIPALQSLDNNGRVIYLGTFSKCLAPSMRIGYMVLPESLLEKYKKQFSFYACTVSRLDQQILFKFIEKDYFEKHLNKMRNIYKKKREKLVSLIKNHLNYTEIIGTNAGLHLLLKVNNGMVESELIKNAKNKGVKVLGLSNSYMNREECEKKATIFLGYASLREEELEDAILLLKSAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLJ2</accession>
    <name>A0A386PLJ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15695</name>
        <name evidence="3" type="ORF">EI377_10415</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678601.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35762">
        <property type="protein sequence ID" value="AYE35762"/>
        <property type="gene ID" value="CP523_15695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61101">
        <property type="protein sequence ID" value="QAS61101"/>
        <property type="gene ID" value="EI377_10415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="530" mass="61883" checksum="7DBD4BCA3E488C1C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLM8</accession>
    <name>A0A386PLM8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13595</name>
        <name evidence="3" type="ORF">EI377_08490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679028.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00087"/>
    <dbReference type="EnsemblBacteria" id="AYE35379">
        <property type="protein sequence ID" value="AYE35379"/>
        <property type="gene ID" value="CP523_13595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60769">
        <property type="protein sequence ID" value="QAS60769"/>
        <property type="gene ID" value="EI377_08490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="105" mass="11477" checksum="3CB72877947F994D" modified="2018-12-05" version="1">MQKINCDVNNCSYNKSGICFSDRIDVGGKAVDHKEDTCCGSFLDKSHYSDLTNATNEEGPCNCIVCQVENCVHNCNKLCDLSSINVAGYGAKIYTETNCNSFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLV6</accession>
    <name>A0A386PLV6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14360</name>
        <name evidence="2" type="ORF">EI377_09270</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35519">
        <property type="protein sequence ID" value="AYE35519"/>
        <property type="gene ID" value="CP523_14360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60904">
        <property type="protein sequence ID" value="QAS60904"/>
        <property type="gene ID" value="EI377_09270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="116" mass="13172" checksum="95128D20F34BF37C" modified="2018-12-05" version="1">MKNGLIALLLGAIIIGGGVVGVNALSNEKNNSELNKNYIEDLEDEIEYKIEIKILEQAKNKLGIKDNEWKTYDELEDIIEEKLGIDDIDDKVDIEDLIEKKLGLDDDVTDYIYNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM64</accession>
    <name>A0A386PM64_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15520</name>
        <name evidence="3" type="ORF">EI377_10225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678706.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35729">
        <property type="protein sequence ID" value="AYE35729"/>
        <property type="gene ID" value="CP523_15520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61068">
        <property type="protein sequence ID" value="QAS61068"/>
        <property type="gene ID" value="EI377_10225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="25707" checksum="4CCC31D750D229D1" modified="2018-12-05" version="1">MKGGLLVTDNVITTLISASAIVTGSLIGAIFSYYISKKTTSKSIKEQYRIQEANREYEEKYKIKEKCTYANVVRLDICTAIFQSIRTLQNKEEISYLYILPISTEYQKAVASLSDKYSLKELSYIYQLYGIIEKVNKDIYNWNYNDLEGDKIIKRGFLDILKKIYGDNYKKILNTDIDKLSYEDLYNNDLIKEGYKEVLMILDNLCYTENLIKERKEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAT8</accession>
    <name>A0A386PAT8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rny</name>
        <name evidence="8" type="ORF">CP523_00595</name>
        <name evidence="9" type="ORF">EI377_11085</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676349.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00650"/>
    <dbReference type="EnsemblBacteria" id="AYE33053">
        <property type="protein sequence ID" value="AYE33053"/>
        <property type="gene ID" value="CP523_00595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61222">
        <property type="protein sequence ID" value="QAS61222"/>
        <property type="gene ID" value="EI377_11085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="329"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="26"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="513" mass="57940" checksum="1C0F4E7AF6D0FE27" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB40</accession>
    <name>A0A386PB40_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ORF">CP523_01020</name>
        <name evidence="12" type="ORF">EI377_11515</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674500.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02315"/>
    <dbReference type="EnsemblBacteria" id="AYE33135">
        <property type="protein sequence ID" value="AYE33135"/>
        <property type="gene ID" value="CP523_01020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61305">
        <property type="protein sequence ID" value="QAS61305"/>
        <property type="gene ID" value="EI377_11515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="4"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="177"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="295"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="438" mass="49696" checksum="D7F1006F124EC6C5" modified="2018-12-05" version="1">MGKPIVAIVGRPNVGKSTLFNRLAGQRISIVQDTPGVTRDRVYAQAEWLNYNFTMIDTGGIEPEREDIIVKQMRRQANIAIETADVIVFIVDGKEGLTPADHEVANMLRKSKKPVVLVVNKVDSLKEEDNAWEFYNLGIGDPITISASQGLGLGDMLDRVVEHFDRVDGEEEEEDIVKIAMMGKPNVGKSSLINRLLGEERLIVSEVAGTTRDAIDSNLETKEGKFTLIDTAGLRRKSKVKEEIERYSVIRTYAAIERADVCILMIDATEGVTEQDEKIVGFAHEMNKAIMVIVNKWDLIEKDDKTMQKYKEDLQMKLKFLKYAKYLFISAKTGQRAHKVLEVAKECYDNYCKRVSTGVLNDVISKAVLMKEPPIVGLKRMKIYYATQVATKPPKFVFFVNDSSASHFSYQRYLENQLRESFNFEGTGIQIEYRERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB91</accession>
    <name>A0A386PB91_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_00375</name>
        <name evidence="5" type="ORF">EI377_10865</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678143.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00586"/>
    <dbReference type="EnsemblBacteria" id="AYE33010">
        <property type="protein sequence ID" value="AYE33010"/>
        <property type="gene ID" value="CP523_00375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61179">
        <property type="protein sequence ID" value="QAS61179"/>
        <property type="gene ID" value="EI377_10865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="108" mass="12518" checksum="D8F1FEA87ADC88BB" modified="2018-12-05" version="1">MKIINSYYELKEFINNNSLSIIYFSTNTCTACNALKPKLISLINEFKDIKIAEVKADKSIELVAQLNMFMVPAILFFVNGKETLRESKYISISELKNKLERVVNLYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBB9</accession>
    <name>A0A386PBB9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00530</name>
        <name evidence="2" type="ORF">EI377_11020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676325.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33040">
        <property type="protein sequence ID" value="AYE33040"/>
        <property type="gene ID" value="CP523_00530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61209">
        <property type="protein sequence ID" value="QAS61209"/>
        <property type="gene ID" value="EI377_11020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="16100" checksum="7E62CACC2BC365E2" modified="2018-12-05" version="1">MIRIKIDKNKKEQPIFKIYIKDIEGYKFLKRSLIEGKKISGKYNYEIPLRFFVPIFNNINKNEINLDSNSKLEFLEFWDEFEEKYYSTLEATPKFMKLWREEGCPDIFKVKINRETLELKKEVVFKKINPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBM6</accession>
    <name>A0A386PBM6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Hydroxyacid dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.272</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02090</name>
        <name evidence="7" type="ORF">EI377_12610</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.272" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674081.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00548"/>
    <dbReference type="EnsemblBacteria" id="AYE33335">
        <property type="protein sequence ID" value="AYE33335"/>
        <property type="gene ID" value="CP523_02090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61505">
        <property type="protein sequence ID" value="QAS61505"/>
        <property type="gene ID" value="EI377_12610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050578">
        <property type="term" value="F:(R)-2-hydroxyacid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="35920" checksum="B5CBBB3E50ABD4C8" modified="2018-12-05" version="1">MKKIVVLDGKTLGNVDYEKLKEFGEVKYFDTTNKDEVIERIKDANIILTNKVVLNESNLKYAKNLELICETATGFNNIDVVYAKENKIAVTNVAGYSTNTVAQHTFATVLSLYDKISYYDGFVKSGNYSKSGLFTDLTKPFYELEGKTWGIIGLGSIGKRVAKIAEAFGVKVIYYSTSGKNYNSEYKRVSFEELLKESDIISIHAPLNKSTNRLMNYNSIKQMKKSALLINMGRGPIVVEEDLAKAIDEKIIAGAALDVFEIEPIKEDNPLVNVKNKENLILTPHIAWASVEARERLFKEIIENIRAFYNGEIRGRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBU6</accession>
    <name>A0A386PBU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein PilZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00464"/>
    <dbReference type="EnsemblBacteria" id="AYE33413">
        <property type="protein sequence ID" value="AYE33413"/>
        <property type="gene ID" value="CP523_02515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009926">
        <property type="entry name" value="T3SS_YcgR_PilZN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12945">
        <property type="entry name" value="YcgR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T3SS_YcgR_PilZN" evidence="2">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="116"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="233" mass="27443" checksum="AEBEC53C42A74CEB" modified="2018-12-05" version="1">MELEQKGYLKGYLIFFLRGEGMAKLELKVNNRLDVIKGKWRYKSIVQDIKDNCLQISVPVIKGRYLTLQNKEDIKIIYYDNNSNLFNFNCKVIERGKDGNIIYYKLSLPYDIKKIQRRDFVRVKIFEFIEYKKVGEILEDKEYENTSYRAILLDLSGGGMKIKSKENLNIGELLLIDINYDDTAVKVKGNVVRGKKKEDSYFYGISFLNIDSKTREKIIKVVFSIMRKQRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBW9</accession>
    <name>A0A386PBW9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS2 family permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00515</name>
        <name evidence="8" type="ORF">EI377_11005</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00632"/>
    <dbReference type="EnsemblBacteria" id="AYE33037">
        <property type="protein sequence ID" value="AYE33037"/>
        <property type="gene ID" value="CP523_00515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61206">
        <property type="protein sequence ID" value="QAS61206"/>
        <property type="gene ID" value="EI377_11005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="430" mass="45681" checksum="D6193425A2581788" modified="2018-12-05" version="1">MEKLFKLKENGVTVKTEAIAAFTSFFAAVYIIVVNASILSDGGVPMEPLIIATVLASLFGCLLVAFISNTPLIIMPGMGINALFTYTIVNTLGLTFYQALGSVFVSGLLFVIIALTPLAKILTEAIPASLKEAITVGIGLFITFIGLQKAGIVVASDSTLVKLGDITSPEVLAFIIIMIITLILFLKNVPGAFLISIIAGTIISIGFGIVDLSNVSFSLPDFNAYKDIFFGMDFSAIATPTFWVATFSLTLVLVFENIGLLHGQVSGMLKRPEETPKALHSVAYSVIGCGIFGTSPNVSTVEGAAGIAAGGKTGLTSAITGLLFLLSLFFIPFIKIIPNAAISPILIIIGCLMSQNLKNLNFDDLTELFPAFATIVLIPLTYSIVDGIAFGFILYPICKLCTKKGKDVSVAMYVVSAIFLIYFILHGMQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCG5</accession>
    <name>A0A386PCG5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NupC/NupG family nucleoside CNT transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_03755</name>
        <name evidence="10" type="ORF">EI377_14285</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675391.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33645">
        <property type="protein sequence ID" value="AYE33645"/>
        <property type="gene ID" value="CP523_03755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61809">
        <property type="protein sequence ID" value="QAS61809"/>
        <property type="gene ID" value="EI377_14285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="PTHR10590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleos_tra2_C" evidence="8">
        <location>
            <begin position="192"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="393" mass="42404" checksum="500553B7B171B4D8" modified="2018-12-05" version="1">MKYIIGIIGLVVVLALAWIGSSDKKKIKYKPIIVMLVLQFIFAFLLLNTQLGNCLVSSIANGFDVLLKCAGEGVDFVFGGLVNNEQFSFFIGVLLPIVVISALIGILQHLKILPFIMKYIGLVLSKVNGMGKLESYNAVASAILGQSEVFISVKKQLGLLPKHRLYTLCASAMSTVSMSIVGSYMVLLEPRYVVTALVLNLFGGFIISSVINPYTVTEEEDILVVREEKKQTFFEVLGEYILDGFKVAVIVAAMLVGFVAIIAMINILFKGVLGISFQDILGYAFSPFAFLMGVPFNESIQAASVMATKLVSNEFVAMNLLASESMNLSVRSIGIVSVFLVSFANFSSIGIISGAVKGLNEEQGNVVARFGLKLLYGATLVSMLTAIIVGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCJ4</accession>
    <name>A0A386PCJ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yajC</name>
        <name evidence="9" type="ORF">CP523_03920</name>
        <name evidence="10" type="ORF">EI377_14445</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01554"/>
    <dbReference type="EnsemblBacteria" id="AYE33675">
        <property type="protein sequence ID" value="AYE33675"/>
        <property type="gene ID" value="CP523_03920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61833">
        <property type="protein sequence ID" value="QAS61833"/>
        <property type="gene ID" value="EI377_14445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="91" mass="10286" checksum="A07FC0E1D280A10D" modified="2018-12-05" version="1">MSNGLLGVIIFLAAYPIIISMIMPIINKKKIRQQEEKRDEYLNTLKIKDKVVTISGIYGTIKGIQNNIVRLEVAKNVEIEIDKASIMVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCQ9</accession>
    <name>A0A386PCQ9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-cone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03345</name>
        <name evidence="6" type="ORF">EI377_13860</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677205.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33570">
        <property type="protein sequence ID" value="AYE33570"/>
        <property type="gene ID" value="CP523_03345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61733">
        <property type="protein sequence ID" value="QAS61733"/>
        <property type="gene ID" value="EI377_13860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="10420" checksum="C900DB5E6BD9287E" modified="2018-12-05" version="1">MKIIKKDGRIEEFDSKKIITSIENAADDIGEMMNESDLKILAQDIERKILEIRKDSLLTSSYEVVGVVFYILKRDEFSDILKAYIEYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCW3</accession>
    <name>A0A386PCW3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33815">
        <property type="protein sequence ID" value="AYE33815"/>
        <property type="gene ID" value="CP523_04670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="66" mass="7554" checksum="7E01BAAC4C002713" modified="2018-12-05" version="1">MNKDTDLFGVIVKKRLIELKMTQRDLAKKLNMNENYLTDILAGRKSGAKYRNNILSEIGLIEELGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCY1</accession>
    <name>A0A386PCY1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01472"/>
    <dbReference type="EnsemblBacteria" id="AYE33650">
        <property type="protein sequence ID" value="AYE33650"/>
        <property type="gene ID" value="CP523_03785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="84" mass="9433" checksum="32E3F22233D836DC" modified="2018-12-05" version="1">MNLLIKNCNNIDLANIEINEYELNIKYGINGTGKSTISKAIKYCIENKEKLIELKPFKYLNGGEEVAPIVEGLEGINTVNIFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD52</accession>
    <name>A0A386PD52_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">cas2</name>
        <name evidence="10" type="ORF">CP523_01645</name>
        <name evidence="11" type="ORF">EI377_12165</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675688.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00880"/>
    <dbReference type="EnsemblBacteria" id="AYE33254">
        <property type="protein sequence ID" value="AYE33254"/>
        <property type="gene ID" value="CP523_01645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61425">
        <property type="protein sequence ID" value="QAS61425"/>
        <property type="gene ID" value="EI377_12165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="10166" checksum="6E21E274CF4B02DC" modified="2018-12-05" version="1">MFVIITYDVNEKRVNRVRKILKKYVTWTQNSVFEGEITEGKLTKCLAEVKKNLVSAEDSLYIYRVSYSKNITKDVVGVEKNLDELFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDJ3</accession>
    <name>A0A386PDJ3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsf</name>
        <name evidence="10" type="ORF">CP523_00740</name>
        <name evidence="11" type="ORF">EI377_11235</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674640.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02372"/>
    <dbReference type="EnsemblBacteria" id="AYE33081">
        <property type="protein sequence ID" value="AYE33081"/>
        <property type="gene ID" value="CP523_00740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61250">
        <property type="protein sequence ID" value="QAS61250"/>
        <property type="gene ID" value="EI377_11235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="72"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="302" mass="33176" checksum="F1AFE246E80073CB" modified="2018-12-05" version="1">MITAQSVKELREKTGAGMMDCKKALTEAQGDMEKAVEILREKGLAAAAKKAGRVAAEGIVKTYISEDKKAAGIVELNCETDFVAANEEFVTFATRLAEMASTTKSTTVEEFVAEKYDAENTVSEALTALIAKLGENMTVRRFEKFAVENGVVQSYIHGGGRIGVVVELACDTASDVLAEVAKDVCMQVAAANPTFLSKEDVDQVALEKEKEIYRVQALNEGKPEKIVEKMVIGRIQKYYKEVCLLDQAWVKDGDKSITKYLQEKSKEVGSPITVTRFVRFERGEGIEKAEDNFAEEVAKMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDM9</accession>
    <name>A0A386PDM9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05120</name>
        <name evidence="3" type="ORF">EI377_15680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01814"/>
    <dbReference type="EnsemblBacteria" id="AYE33900">
        <property type="protein sequence ID" value="AYE33900"/>
        <property type="gene ID" value="CP523_05120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62051">
        <property type="protein sequence ID" value="QAS62051"/>
        <property type="gene ID" value="EI377_15680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="73"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="28780" checksum="CF2DCDF4BECFA28B" modified="2018-12-05" version="1">MQLIIFLRFFLIKNIFKFFIIFSKKLLFTAYLLCRGVFKFYLNNKLGGYIMCFCELLSTAQKGNTSSVEEIINLFYPLVLKEAKKVYLKSYTFEDLIQLGVLNVIKAIYMFDINKNINSFSSYVFWSVKNGFGYLCRKEVRYNEICSLDFNSTEDLSLIDFLPAANNIENEVVEKSDILELNLALSKLNKEELELITFIYLGKDKRTLTSYCKEMKKDYYYATRIKKQSLDKLRNFLSFNIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDP2</accession>
    <name>A0A386PDP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677897.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02241"/>
    <dbReference type="EnsemblBacteria" id="AYE33587">
        <property type="protein sequence ID" value="AYE33587"/>
        <property type="gene ID" value="CP523_03450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="370" mass="39505" checksum="CBD9B650546F1DCE" modified="2018-12-05" version="1">MKNKGLKSILAVVLGLLAGAILMAIIGSNPIEGYSYLFQGGLKNIERIANTVATATPLILTGLSVAFAFRTGLFNIGAAGQMLFGGLCATAVGLTVNLPRPLLLITMILAGFLGGALCAAIPGIFKARYNVNEVVSTIMMNWIAYWVVYYTIPAYFKGAFLETESAKLSPEASLQAPWISELFQGSFINYGFLIAIIAVLLIAFILNKTVLGYELKAVGFNRYAAEYSGMPVKRNIVLSMMISGGLAGLAGVAQYAGNIANMQIGVTPSQGFDGIAVALLGSNSPIGVLFAALFFGLLYTGKGFMSAMTSIPPEIADTIMATIIYFAATSAVMDRVFDKFRRRKVQMNTNKLATDGTSERNDKKERKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDQ8</accession>
    <name>A0A386PDQ8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_01050</name>
        <name evidence="14" type="ORF">EI377_11545</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the system for phosphate transport across the cytoplasmic membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674486.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02309"/>
    <dbReference type="EnsemblBacteria" id="AYE33141">
        <property type="protein sequence ID" value="AYE33141"/>
        <property type="gene ID" value="CP523_01050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61311">
        <property type="protein sequence ID" value="QAS61311"/>
        <property type="gene ID" value="EI377_11545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011862">
        <property type="entry name" value="Phos-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02136">
        <property type="entry name" value="ptsS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7 11" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034114062" description="Phosphate-binding protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="12">
        <location>
            <begin position="36"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="29897" checksum="F61C9836EE405B99" modified="2018-12-05" version="1">MKKKSLKLLCTSLIISMMGGVFVGCSGKGESNGSSAGENIRVSISGSTSVGPLMEKVAEKYEAENSNVSIEINQVGSSAGIKDAINGVSEIGMSSRKLKDEEEAEVKGSVIAYDGIALITNKNNKVTNITMGQIKDIYTGKITNWKDIGGVDAPIVVVSREDGSGTRDAFQEIVGYKSENLISNATISDGNGNVKTIVEGNENAIGFVSFEYLDDKVGQLTVDGVKPEANLVKSGEYKLSRPFILATKEGNITENGKKIVEYILSDAGQKIVEENKLITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDV4</accession>
    <name>A0A386PDV4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycyl-radical enzyme activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_00470</name>
        <name evidence="13" type="ORF">EI377_10960</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676304.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00623"/>
    <dbReference type="EnsemblBacteria" id="AYE33028">
        <property type="protein sequence ID" value="AYE33028"/>
        <property type="gene ID" value="CP523_00470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61197">
        <property type="protein sequence ID" value="QAS61197"/>
        <property type="gene ID" value="EI377_10960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="35050" checksum="116CE2DDE3DADA0F" modified="2018-12-05" version="1">MENKIDYDKRGIIFNIQRFSVNDGPGVRTIVFLKGCPLSCLWCSNPESQNSFKELMFNIKNCVGCENCKDICKENAIDFNNVNRIDRDKCINCIDCSEVCYPGALVISGEEKSVEEVISELKKDSTHFRHSNGGITLSGGEPLMQPEFTLELLKGCKANGWHTTIETTGFASKEVVDKIIPWVDLILLDIKHMDSDIHLQNTGQRNEIILENAKRISELGVDTIIRTPVIPGFNSEKKTIEKIAKFANTLKMVKEIHILPYHRLGLNKYNCLDRKYKIKDYIVTPSKEYMDELKETIENIGIKCNIGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE45</accession>
    <name>A0A386PE45_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01756"/>
    <dbReference type="EnsemblBacteria" id="AYE33524">
        <property type="protein sequence ID" value="AYE33524"/>
        <property type="gene ID" value="CP523_03100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="755" mass="84636" checksum="E6D39B210E348772" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ0</accession>
    <name>A0A386PEJ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33076">
        <property type="protein sequence ID" value="AYE33076"/>
        <property type="gene ID" value="CP523_00715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="325" mass="37588" checksum="27412F9D162D4DF4" modified="2018-12-05" version="1">MKIDYKYTKVIKLMVLFITFVLITFLIKEYFTPFFIIAFMLLINHPIYKFINKRNINKNISAIFSLIIVNITLFFIIFYFGNTLITLFQKFYVENTLAVDNFFNNIKVLLNFDLNKVIENLSKILNSSIILQGASITGEGLISYFIGNIATYFVLVDKDKVYKLLSMILPKEVVRNIYIKKSNLKEVFKIEIILVFFTALITIIGFKILGMNNSLFLGIICGILDILPYVGTIIVFIPIIIYNIIMKRYLLVIGFIGLYFLIQVIREVLEAKFLSNKLDIHPLVVMISIYVGVKMFGFVGIIAGPIYCIIAKDIIYNEQEETIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK6</accession>
    <name>A0A386PEK6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HU family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08550</name>
        <name evidence="6" type="ORF">EI377_03300</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016206851.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01651"/>
    <dbReference type="EnsemblBacteria" id="AYE34475">
        <property type="protein sequence ID" value="AYE34475"/>
        <property type="gene ID" value="CP523_08550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59877">
        <property type="protein sequence ID" value="QAS59877"/>
        <property type="gene ID" value="EI377_03300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="91" mass="10185" checksum="F33D66BE3EC0CCFD" modified="2018-12-05" version="1">MNKAELITSMSEKSKLTKKDAELALKAFIESVEEALEKGEKVQLVGFGTFETRERAAREGRNPRTKETINIPASTVPVFKAGKEFKEKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEL8</accession>
    <name>A0A386PEL8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Site-2 protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CP523_02000</name>
        <name evidence="17" type="ORF">EI377_12520</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678896.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00132"/>
    <dbReference type="EnsemblBacteria" id="AYE33318">
        <property type="protein sequence ID" value="AYE33318"/>
        <property type="gene ID" value="CP523_02000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61488">
        <property type="protein sequence ID" value="QAS61488"/>
        <property type="gene ID" value="EI377_12520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="23702" checksum="8BDD8B366E5CF4C7" modified="2018-12-05" version="1">MRNYLLNIILTVPAILVAFTVQGYSRALVADKLGDKTPRFQGRLTLNPAAHIDPIGFIMILLVHFGWTKPVDTNPNAYKRGYKDAIKVSIAAPLGNLIIGLIFTFIYAFWAALAKSLPTNFYLTGLSMLLYIAVINVNLFVFNLIPLPGLAGFDILRDLWPKTFYKVADTIYQYQILILMGVLLIGSKLISIPSSLIFNLFTKIAFSVVGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES2</accession>
    <name>A0A386PES2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">thrS</name>
        <name evidence="13" type="ORF">CP523_04280</name>
        <name evidence="14" type="ORF">EI377_14805</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676487.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00422"/>
    <dbReference type="EnsemblBacteria" id="AYE33744">
        <property type="protein sequence ID" value="AYE33744"/>
        <property type="gene ID" value="CP523_04280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61900">
        <property type="protein sequence ID" value="QAS61900"/>
        <property type="gene ID" value="EI377_14805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="268"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="636" mass="73686" checksum="FF6A1D9FF56A5C17" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX3</accession>
    <name>A0A386PEX3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04555</name>
        <name evidence="2" type="ORF">EI377_15110</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33794">
        <property type="protein sequence ID" value="AYE33794"/>
        <property type="gene ID" value="CP523_04555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61952">
        <property type="protein sequence ID" value="QAS61952"/>
        <property type="gene ID" value="EI377_15110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="14917" checksum="66469FB945805FFC" modified="2018-12-05" version="1">MKINDGFILLSKDKELLNGGNVEFSGDSIPNINYYSKSIFIDKHGERDTILLNSISHEGDYKVDSLRDELLANKTIGTISSETLFSNTDIDSIKDNLYFCFEYKTTNNEKKEIVVKLDVNEVNLNSVNLVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF07</accession>
    <name>A0A386PF07_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BglG family transcription antiterminator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_05820</name>
        <name evidence="8" type="ORF">EI377_00305</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674996.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01865"/>
    <dbReference type="EnsemblBacteria" id="AYE34017">
        <property type="protein sequence ID" value="AYE34017"/>
        <property type="gene ID" value="CP523_05820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59389">
        <property type="protein sequence ID" value="QAS59389"/>
        <property type="gene ID" value="EI377_00305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="189"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="303"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="5">
        <location>
            <begin position="416"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="4">
        <location>
            <begin position="510"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="649" mass="74508" checksum="D7C58E03C133DB6B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF29</accession>
    <name>A0A386PF29_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08215</name>
        <name evidence="4" type="ORF">EI377_02965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674703.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01585"/>
    <dbReference type="EnsemblBacteria" id="AYE34410">
        <property type="protein sequence ID" value="AYE34410"/>
        <property type="gene ID" value="CP523_08215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59815">
        <property type="protein sequence ID" value="QAS59815"/>
        <property type="gene ID" value="EI377_02965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08215"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Gate_dom"/>
    </dbReference>
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        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="191" mass="20286" checksum="8D45166581831463" modified="2018-12-05" version="1">MINYIWFVMIFLGIIVGLFTGNGDGISKAIIGSVDSTVSLIIGLVGLMCFWCGVMKVAEKSGLTNKLAKLLRPILRLLFKDAAKDEKALGAIVMNITANMMGLGNAATPFGIKAMQEMDRLNKEKGTASNDMVLFLVLNAACIQLVPSTIISIRAACGSTNPGSIILPAILASTIAAIVGVICCKILQRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF88</accession>
    <name>A0A386PF88_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylglucosamine--LPS N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_10095</name>
        <name evidence="8" type="ORF">EI377_04895</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676588.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00348"/>
    <dbReference type="EnsemblBacteria" id="AYE34725">
        <property type="protein sequence ID" value="AYE34725"/>
        <property type="gene ID" value="CP523_10095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60126">
        <property type="protein sequence ID" value="QAS60126"/>
        <property type="gene ID" value="EI377_04895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="198"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="366" mass="41457" checksum="961BB4952289D35C" modified="2018-12-05" version="1">MKKILIFSTSTGEGHNQAANSISSTLEKNGYEVVRNDFLVSNSKILTKFFVGGYEISASIFQKTYGFFYKLTDTFLTNKILSFICFLLRKKVFKYINTIQPDIILLTHPFAVNILGSLKRKGLEIPVISIVTDFKAHSTYIDKDIDAYITASEFTKKDLSKRGISSDKIFPFGIPVKDEFLESNPLIRTTKNDEYFNILLMSGSMGLKNISYVLKELLNNSHKLRITVVCGNNTKLKENLLKEYKHVIKDKKLHILGFSRDVDSLMEYSDLIISKPGGLTITEAINKNLPILIPFAIPGQETQNVEFLTSHGYALYTDNLLELNLIVDDLINNPNKLYSIRNKLNILASTYSKINIVKLADKLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA6</accession>
    <name>A0A386PFA6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01270</name>
        <name evidence="3" type="ORF">EI377_11770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674345.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02264"/>
    <dbReference type="EnsemblBacteria" id="AYE33182">
        <property type="protein sequence ID" value="AYE33182"/>
        <property type="gene ID" value="CP523_01270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61352">
        <property type="protein sequence ID" value="QAS61352"/>
        <property type="gene ID" value="EI377_11770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="17329" checksum="ACF3DC083376948D" modified="2018-12-05" version="1">MKRSEKVVNELLVKIFDDILEIEEKTLKQGHLSDLSVTEMHTIEAIGMYSYRTMSEVAQDLDITVGTLTTAINKLIKKGYVERKRIEEDRRVVLVGLTKKGKLAYRLHEKFHNEMVQSTIEGLTEEEEEILIASLERLSEYFKTKRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF5</accession>
    <name>A0A386PFF5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04320</name>
        <name evidence="2" type="ORF">EI377_14855</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33751">
        <property type="protein sequence ID" value="AYE33751"/>
        <property type="gene ID" value="CP523_04320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61908">
        <property type="protein sequence ID" value="QAS61908"/>
        <property type="gene ID" value="EI377_14855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="7033" checksum="F9956CAC3FF3CBB9" modified="2018-12-05" version="1">MSSLREESLKKLREDNVYKNLVELRKSLKPGEIVEGYFETLNYTSEKQRKSPISGESVLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN2</accession>
    <name>A0A386PFN2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2828 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF2828 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00190</name>
        <name evidence="2" type="ORF">EI377_10705</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677390.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01194"/>
    <dbReference type="EnsemblBacteria" id="AYE32979">
        <property type="protein sequence ID" value="AYE32979"/>
        <property type="gene ID" value="CP523_00190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61153">
        <property type="protein sequence ID" value="QAS61153"/>
        <property type="gene ID" value="EI377_10705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="PTHR31373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="489" mass="57339" checksum="A806F3B58090B79F" modified="2018-12-05" version="1">MANKFINKFREELYKVSSIDDLQSDNNQSAVLEFLQEVPNLRNEGDDKIIELFRRVLYSNKILAIKSLFYVRDKKCGEGERRIFNILIKYLALSNPDLLKKNLHLIPKYGRWDDFYSLFDTPLESNVICIFKRQITLDLNCKSPTTLGKWLKSENTSSKASKLLGKKTRELLGYTPKEYRKILSTLRKKIGIIEHNLSSKNYSNINYSKLSLSTIIRYRKALIKNDKIEFQKHLKSLKQREKKRSIKLDKNILTETPFNVVDNILNDNNRENIDVYSNLWNVVCNNYISDIKDTLITLAISGSGCNKHSISYKLAISNILLYKKFNNNRFKNHYIYFDKNPKFMKIEPLSLYEQIESIKANNLFSEINISTALDMILFTSLKEGLTYKEIPQNILIISNNSLDEDYFTEELLKEIKEKWKLAGFLLPNIKLWIIDEDDNNKSIFNKNNCIIIKGYSKELFKLSIKGECISEKLLMIRKLEDNRYEDIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR4</accession>
    <name>A0A386PFR4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4318 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06220</name>
        <name evidence="2" type="ORF">EI377_00695</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679192.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34094">
        <property type="protein sequence ID" value="AYE34094"/>
        <property type="gene ID" value="CP523_06220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59461">
        <property type="protein sequence ID" value="QAS59461"/>
        <property type="gene ID" value="EI377_00695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025467">
        <property type="entry name" value="DUF4318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14201">
        <property type="entry name" value="DUF4318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="74" mass="9164" checksum="16B1C06CF98653EA" modified="2018-12-05" version="1">MKKCFVINLNEKPNNSQEICEYISKYCNKQNQYFEFTSRKTPISFYLENTLYRVKLGKSFKNFYYRWILYCNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG03</accession>
    <name>A0A386PG03_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TerD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TerD family tellurium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05340</name>
        <name evidence="4" type="ORF">EI377_15905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677992.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02600"/>
    <dbReference type="EnsemblBacteria" id="AYE33941">
        <property type="protein sequence ID" value="AYE33941"/>
        <property type="gene ID" value="CP523_05340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62092">
        <property type="protein sequence ID" value="QAS62092"/>
        <property type="gene ID" value="EI377_15905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="209" mass="23034" checksum="293796AD9EA2DE08" modified="2018-12-05" version="1">MGINLGSLMGSSNSEVLSNNGVNALNLKKNDVLNLTKRNPGLQKVILGAGWDVANNGQDFDLDIAAFLVNSNNKVQNIPEDVIFFNNMKGQGIALEGDNRTGAGEGDDERIRIDLSQIPSYVQKIVFVVTIHEAQVKRQTFGMVENSFVRLLDEKNNEREICRFNLKENGSTSTSVIFAEINKVQGEWEFRAIGEGKIADLNGILGLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG24</accession>
    <name>A0A386PG24_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02875"/>
    <dbReference type="EnsemblBacteria" id="AYE35005">
        <property type="protein sequence ID" value="AYE35005"/>
        <property type="gene ID" value="CP523_11585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="295" mass="34617" checksum="B2230C75EC73F773" modified="2018-12-05" version="1">MIFNLHFAKFSIMQFFYIIIKFRLEVDSMKNKYMVGEVSKFLNISKDTLRYYDQIGIVTPKKSGKNGYRYYTMDNIVLLTYVLVLKDLDVPLNEIKNILSNNSLESMIKLIGNQKRVVEKKIKELQGIKSTINSLEKAFIQAYNYNNKFEVIESPKFIYKEIGEEIDSTMSTVMDEFRSINGLSEIVYTVIIKNICDIKKIVDNNIFYTVSARIEKFENEFYIGKTNIFEKSKCIHTVIRSSDDIKEIDLMELKKYLKENSFTINGDIIARAIAFEHIDEKPIDYYEVWVPIKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG49</accession>
    <name>A0A386PG49_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04900</name>
        <name evidence="2" type="ORF">EI377_15410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675746.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33858">
        <property type="protein sequence ID" value="AYE33858"/>
        <property type="gene ID" value="CP523_04900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62003">
        <property type="protein sequence ID" value="QAS62003"/>
        <property type="gene ID" value="EI377_15410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="16016" checksum="41A9F97A46CE7D41" modified="2018-12-05" version="1">MEALMKINNIKEACSKYVLNFDGEIYETNDEKSIIQGMDNTYLESNDNNLLLEKRIYLAKKILLYSIMLNLKVEIHNGSEKLEENYKVDKDNSGNEVYYEEPDIILNVEDEISMFKGINSTSFASVYKKNDCGEYELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG84</accession>
    <name>A0A386PG84_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">clpP</name>
        <name evidence="11" type="ORF">CP523_11860</name>
        <name evidence="12" type="ORF">EI377_06680</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673431.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02930"/>
    <dbReference type="EnsemblBacteria" id="AYE35053">
        <property type="protein sequence ID" value="AYE35053"/>
        <property type="gene ID" value="CP523_11860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60446">
        <property type="protein sequence ID" value="QAS60446"/>
        <property type="gene ID" value="EI377_06680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="200" mass="22227" checksum="44C0F20DA423125E" modified="2018-12-05" version="1">MSLVPMVVEQTSRGERSYDIFSRLLKDRIIMLSGEINDTTANLVVSQLLFLESEDPDKDIYIYINSPGGSITAGMAIYDTMQYIKPDVSTICIGMAASMGSFLLSSGAKGKRFALPNSEIMIHQPLGGFQGQATDFDIHAKRILKIKDSLNRILSENTNQPIEKIKADVERDYFMSAEEAMNYGLVDKVITKKEKGSDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA4</accession>
    <name>A0A386PGA4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10575</name>
        <name evidence="4" type="ORF">EI377_05360</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674180.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01386"/>
    <dbReference type="EnsemblBacteria" id="AYE34810">
        <property type="protein sequence ID" value="AYE34810"/>
        <property type="gene ID" value="CP523_10575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60204">
        <property type="protein sequence ID" value="QAS60204"/>
        <property type="gene ID" value="EI377_05360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="189" mass="21289" checksum="284AFEDA05440ECD" modified="2018-12-05" version="1">MKYILASASARREELLHRIIDDFEIKVSDFNEDSISFDGYNIPEYVIKLAQGKVFNVEKTTNDKAIIIGADTIVTLDNKILGKPKDEKDAFYMLRLLSGKTHRVYSAVVVLNTDNSKIEKECIYTEVKFSELTDEDIKKYIKTKEPLDKAGSYGIQGVGGVFVESINGCYYNVVGLPLNVLNKMIKSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC3</accession>
    <name>A0A386PGC3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06095</name>
        <name evidence="2" type="ORF">EI377_00575</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675120.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01920"/>
    <dbReference type="EnsemblBacteria" id="AYE34071">
        <property type="protein sequence ID" value="AYE34071"/>
        <property type="gene ID" value="CP523_06095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59442">
        <property type="protein sequence ID" value="QAS59442"/>
        <property type="gene ID" value="EI377_00575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="114" mass="13449" checksum="AB5C02AEFD864CA7" modified="2018-12-05" version="1">MKFKLEKNLRIVSELITYFHKLGTDDVHLDIKSEDDKSYFYISGEVLNLPQEELNNLNLILNTQRQHEIEHYYWNLGGESELDCELSLIGMMVDDVIITYENNILTLKILRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD1</accession>
    <name>A0A386PGD1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08745</name>
        <name evidence="2" type="ORF">EI377_03495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678061.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34497">
        <property type="protein sequence ID" value="AYE34497"/>
        <property type="gene ID" value="CP523_08745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59899">
        <property type="protein sequence ID" value="QAS59899"/>
        <property type="gene ID" value="EI377_03495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019700">
        <property type="entry name" value="Sigma-G_inhibitor_Gin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10764">
        <property type="entry name" value="Gin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="8556" checksum="AB82A5B770D5CD23" modified="2018-12-05" version="1">MKIKFKDIQKGRNEKVCFVCRNQEENGIIIARKLICKSCQSKILNANINSKQYDFYKDKIKEALTSKYNFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD4</accession>
    <name>A0A386PGD4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01560</name>
        <name evidence="2" type="ORF">EI377_12080</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675664.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33239">
        <property type="protein sequence ID" value="AYE33239"/>
        <property type="gene ID" value="CP523_01560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61411">
        <property type="protein sequence ID" value="QAS61411"/>
        <property type="gene ID" value="EI377_12080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="315" mass="36604" checksum="50B1E44F9E17EB61" modified="2018-12-05" version="1">MNIINLNDNMFEFKSNFSFMLENTYELLDTNIKVSKSFSKILNNTSIFLYGEYEVITLIMEKSNGYTDYKTKNFKVSFINSFKYEKLSFINDLYINSIKITCEFLDTPNIDIIIDFDKYNKKIIKGTIYYKIKFKFNSKDNLNYLSNKKSTNFSNIEALVVVGFGNENILFSDYIDLFENSPPIFKIISSYNEVKIETSSCKGEIAYVNGYVDLSFQYISLENYTNNSSSGAIYFFNKKLPFSSLINLKAEKGKKLLKTDICSLIKVSSDKEIINLEDPIKVSENLFVYKKIYLKLPININLTIVRNENININTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE4</accession>
    <name>A0A386PGE4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01615</name>
        <name evidence="2" type="ORF">EI377_12140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675684.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33249">
        <property type="protein sequence ID" value="AYE33249"/>
        <property type="gene ID" value="CP523_01615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61421">
        <property type="protein sequence ID" value="QAS61421"/>
        <property type="gene ID" value="EI377_12140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="15312" checksum="EA89D1FA85A13E2F" modified="2018-12-05" version="1">MKYELTIYELGKLLKNIDSKYNISLLSKIKLSGGWMTMTGEISVIDVPTEAILLKGNNIITLKLKNNNENGSEIKITGLKDSKFVIDISATKYKEIKPGMLNLDVIKVNNNQCKLRIDEDMIFTIDTSVDKVIKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGK0</accession>
    <name>A0A386PGK0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_07905</name>
        <name evidence="9" type="ORF">EI377_02600</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675872.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00684"/>
    <dbReference type="EnsemblBacteria" id="AYE34354">
        <property type="protein sequence ID" value="AYE34354"/>
        <property type="gene ID" value="CP523_07905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59751">
        <property type="protein sequence ID" value="QAS59751"/>
        <property type="gene ID" value="EI377_02600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="46"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="33674" checksum="A22A8A3D713EF63B" modified="2018-12-05" version="1">MGEKGLFLKYEDILKDSISNTSYNKIIELLAELQEKNTKQEELLLNISHDMRAHLNVILSIMQCIECGNVDIEDKKAIEYMKIVKRNSLKMLKLINNLIDTTRLENNYYVLNKKNIDIVSMIEGTISCIDRYAKQKNIQLIFDTNEEECIIAADPEVIDRIVMNLISNAIKFSSEDKNVYIDLYISEKEVEIIVTDEGVGISKEDQKKIFDRFYQISKKKSNENSGSGIGLDLVNYLVKTHDGKIDIVSEEGEGSSFIVKLPITIVKENNIITERGNSDKIQMLEIEFSDIYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL8</accession>
    <name>A0A386PGL8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12770</name>
        <name evidence="2" type="ORF">EI377_07645</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678180.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35225">
        <property type="protein sequence ID" value="AYE35225"/>
        <property type="gene ID" value="CP523_12770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60620">
        <property type="protein sequence ID" value="QAS60620"/>
        <property type="gene ID" value="EI377_07645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="106" mass="12194" checksum="AA05A4EDE450562D" modified="2018-12-05" version="1">MRIDFRNVGKSKIYISTDNKEYIEVCDILGNVYKVNRENITEVSFIPDNVAITIMGLPTSRFKSTLKISFKDIEGKGEEKLVIYNDASKLLIEDAYKEVKAWINLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN3</accession>
    <name>A0A386PGN3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ORF">CP523_11240</name>
        <name evidence="6" type="ORF">EI377_06035</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677031.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00892"/>
    <dbReference type="EnsemblBacteria" id="AYE34940">
        <property type="protein sequence ID" value="AYE34940"/>
        <property type="gene ID" value="CP523_11240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60334">
        <property type="protein sequence ID" value="QAS60334"/>
        <property type="gene ID" value="EI377_06035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="52"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="31929" checksum="43BDED7BA707DB64" modified="2018-12-05" version="1">MNCDRNEKCWCGSGLKYKKCHMEIEEKIHALQAKGFIVPSRDIIKNKQQIDGIRESAKINNAVLDLVSKNIKLGMSTEEINKIVHDYTVSQGAIPAPLNYGGFPKSVCTSINDEICHGIPSEDIILKDGDIINVDVSTIYNGYYSDASRMFMIGNVSEEDKRLVKVAKECLIKGVEAVKPWGFLGDIGATIQEHAEKNGYSVVRDFGGHGVGINFHEDPFVSHVGKKGEGMVLVPGMVFTIEPMINQGSYELFVDEDNDWTAITEDGGYSAQWEHTVLVTEDGVEILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN6</accession>
    <name>A0A386PGN6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">glgA</name>
        <name evidence="10" type="ORF">CP523_06885</name>
        <name evidence="11" type="ORF">EI377_01370</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679175.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00042"/>
    <dbReference type="EnsemblBacteria" id="AYE34201">
        <property type="protein sequence ID" value="AYE34201"/>
        <property type="gene ID" value="CP523_06885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59566">
        <property type="protein sequence ID" value="QAS59566"/>
        <property type="gene ID" value="EI377_01370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06885"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="290"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="477" mass="55446" checksum="D5C8EC62F43E31B7" modified="2018-12-05" version="1">MKILMVASEAHPFIKTGGLGDVMGALPQALKNQGIDIRVIIPKYQYINENFVKSLKFIKAFRVKVGWRNQYCGVFQCEYKGVIYYFLDNEYYFKRKELYGHYDDGERFAFFNRAVLETINQLNWKPDVIHCNDWQTGMIPVLYKLEYQKREFYKNIKIFFSIHNLLFKGVMSPKILPELFGYDYEPFLNGSLELDGGVSFLKGGINYSDQILTVSETYAWEIQTREYGEGLEGLLKERSYALKGIINGIDYEEYNPKNDKFICKTYSESEIDNKVINKEKLQRQLGLPVNRDIPMIGMVTRLTHQKGCDLIINILDRLLQRDIQVVILGTGDYLYEETFRNFNYRYHDKVSVNINFDNSLAHKIYAGSDLFLMPSLFEPCGLGQLIALRYGTLPIVRETGGLRDTIKPYNKYNGVGNGFGFVNYLGNELMEVTEYALEIYKDKNTWNSLIAQAMRSDNSWEKSANEYRRLYGEVIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT7</accession>
    <name>A0A386PGT7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02445</name>
        <name evidence="2" type="ORF">EI377_12970</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00478"/>
    <dbReference type="EnsemblBacteria" id="AYE33399">
        <property type="protein sequence ID" value="AYE33399"/>
        <property type="gene ID" value="CP523_02445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61573">
        <property type="protein sequence ID" value="QAS61573"/>
        <property type="gene ID" value="EI377_12970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="188" mass="22016" checksum="CCE0411EDC1D21E9" modified="2018-12-05" version="1">MNLDVKFSNRNEKKINYFLDKIHLSYGEEILDVGTGDGILIPFIMEKCGDCKIDAVDISDVMLEFAKSKYGNLPQVVFKKINVENNKITKKYNKIILYSVFQYIQRKVETIYNLVNENLKIDGKLIIAYPNSRKYLNNLHNSKRKYLNEDRLIDVNLQKNLFKLAGLDVVEAFENDDMYYLIIKRVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV2</accession>
    <name>A0A386PGV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679050.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01953"/>
    <dbReference type="EnsemblBacteria" id="AYE35315">
        <property type="protein sequence ID" value="AYE35315"/>
        <property type="gene ID" value="CP523_13255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009660">
        <property type="entry name" value="Phage_A500_Gp15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06854">
        <property type="entry name" value="Phage_Gp15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="200" mass="23582" checksum="3B913F6B12BB94C4" modified="2018-12-05" version="1">MNLLIDLAPITVDIDGIEYGINSDFRTSILFELLMQDNEINEEYKIINALELYYPVVPTNINEAVEKILWFYRCGKDISYQKRNAKCKGGTQIYSFEHDDDYIYSAFLDQYGVDLQDIDYLHWWKFKAMFKSLKEDNEIVKIMGYRSIDLSKIKAKEEKMHYRKMKELYKIPKNISASEEAKLKNIEEALLSGKDLMNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW1</accession>
    <name>A0A386PGW1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_04540</name>
        <name evidence="10" type="ORF">EI377_15100</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676399.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00369"/>
    <dbReference type="EnsemblBacteria" id="AYE33792">
        <property type="protein sequence ID" value="AYE33792"/>
        <property type="gene ID" value="CP523_04540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61950">
        <property type="protein sequence ID" value="QAS61950"/>
        <property type="gene ID" value="EI377_15100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="253"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="348" mass="39951" checksum="C3484B2DB14B3CCA" modified="2018-12-05" version="1">MNRKTKHRQVEICLIITFIISIFSFSFIISASETTFKMVTSRNSFKDKLKYVQIEGKNSGKDLIELLNEREVKQIMTPEIVEKIEAESVNYVGKVVGVTSGADIEKYCKITGRILTNNEIDEGKKVAVVGSKLKKCIINVDNKDYIKLFKENFEVVGIIENEEWLTGEIFIPIKTHPDYEFVTENNVVVVDKTEVNKVKNIKDIGIKVSDIPKEKVSEFVLTRIPEIKENMFMVLVAFLNLVIFSIFYCQYIKRDLAIMRLVGAKPKDIVKYMFSKVSKIYLKALPIGFLTSFITIKVANSFYTKVMFDPISIYNVIITIGLTILIFIVANFIVLFNVLRFNILEDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGW9</accession>
    <name>A0A386PGW9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRAM_POS_ANCHORING domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33866">
        <property type="protein sequence ID" value="AYE33866"/>
        <property type="gene ID" value="CP523_04940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017410115" description="GRAM_POS_ANCHORING domain-containing protein" evidence="5">
        <location>
            <begin position="31"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="6">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="337"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="428" mass="47928" checksum="ECCF46871D3DBA5C" modified="2018-12-05" version="1">MIKIKVKKIICAALASGVLIGVTPALNIVATTNEVIEDSNLTEEQLEQLNYAIEEMKIAIDLVDNADFTDGTSYERMVAFATASLDRVRGLEINNEHVEWIEESGDEVRDLTYRINRVLHAIKNVEIVFSEDRQDTVENKENVINTLNLVLTQEMEVGILNNATLRSAVNILHMYNGKIDSPDVEKPGLTEEQLEQLNYAIEEMKIAIDLVDNADFTDGTSYERMVAFATASLDRVRGLEINNEHVVWIEESGDEVRDLTYRINRVLHAIKNVEVVFSEERQDTVENKQNVLDTLKLIISQEETSEILNEYTIESAKNIYKHYYAILNFGDGSSDDDMLYPGIGEKPEEGQKPEEGEKPEEGETPEGGDKSESGIYTPTDLGNNDAKVSSNKQENSTELPKTGAETTSLALGFFTTLLGLITIKNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX6</accession>
    <name>A0A386PGX6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33439">
        <property type="protein sequence ID" value="AYE33439"/>
        <property type="gene ID" value="CP523_02650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="300"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="386" mass="42038" checksum="76D281DC33C50FBA" modified="2018-12-05" version="1">MIINHNMNAMNAHRNMASNTVATGKSMEKLSSGLRINRAGDDAAGLSISEKMRGQIRGLEQASRNSQDGISLIQTTEGALNETHSILQRMRELSVQASNDTNTAEDRGQLTKELDQLRSEIDRISSQTQFNKMDVLNGDGDKSFKANIQVGANSNQAIEIAIDKMDYSSLFKAHKVTSAEEVKGDITVKATKDIKVTIDTKEITIKADKTDKTLTKEELVAEINKGIEAEATLKGKVSASFEGNKLTISRIDGEDKEVTVKVEDNNGAGNTKLGLDGDNKSKMEVFNVDLTSHAAATGSISAIDRAIEKVSTQRSQLGAYQNRLEHTIKNVDNAAENLQAAESRVRDVDMANEMMTFSKNNILTQAAQAMLAQANQQPQGVLQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ6</accession>
    <name>A0A386PGZ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sporulation membrane protein YtaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ytaF</name>
        <name evidence="6" type="ORF">CP523_13460</name>
        <name evidence="7" type="ORF">EI377_08360</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677570.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00789"/>
    <dbReference type="EnsemblBacteria" id="AYE35353">
        <property type="protein sequence ID" value="AYE35353"/>
        <property type="gene ID" value="CP523_13460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60744">
        <property type="protein sequence ID" value="QAS60744"/>
        <property type="gene ID" value="EI377_08360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014205">
        <property type="entry name" value="Spore_YtaF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02840">
        <property type="entry name" value="spore_YtaF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="207" mass="22795" checksum="37C03822B8E8CD1B" modified="2018-12-05" version="1">MLETLLLVLSVSIDSFVASIAYGTDKIKIPILSALIIDIVCSAMLGVSLLLGSLIKDYIPSTVAISISFLILFGLGVYRLFESIFKNYIKNKSNALKPLTFKMFDFNFVLQVYADETKADFDKSKILTSKEAFYLAFALSLDSLAVGFGSSLISVNYLQAIIFCLILGMMAILTGVYIGRKFIEKVDIDLSWLSGALLILLAIMRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH10</accession>
    <name>A0A386PH10_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13515</name>
        <name evidence="3" type="ORF">EI377_08415</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677587.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00799"/>
    <dbReference type="EnsemblBacteria" id="AYE35363">
        <property type="protein sequence ID" value="AYE35363"/>
        <property type="gene ID" value="CP523_13515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60754">
        <property type="protein sequence ID" value="QAS60754"/>
        <property type="gene ID" value="EI377_08415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="275" mass="31217" checksum="8B66EAC90C0A6DF0" modified="2018-12-05" version="1">MIKYDLHTHSTSSDGRYSPRDVVKLAKENGVEYLALTDHDTLSGINDALLEAKKLNINFIPGIELSTEFNHESIHVLGFFKGDDYKNPELKGFLESLKEKRIKRAYEIVERLKKYNNIEIDINNVLKNGKDTIARPHIAKAIIEAGYPHDHEYIFKNILGDNCPAYVPSAKITTEEGIKLLKKYNALVFLAHPVLVKHTPIKELLKLGFDGLEAIYFRNKSKKTKEFLHLAEELNLLVSCGSDCHGIPNDCSHGTVGEIPFPDDIDVDKYMNWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH13</accession>
    <name>A0A386PH13_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cutC</name>
        <name evidence="3" type="ORF">CP523_09860</name>
        <name evidence="4" type="ORF">EI377_04645</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676755.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02678"/>
    <dbReference type="EnsemblBacteria" id="AYE34687">
        <property type="protein sequence ID" value="AYE34687"/>
        <property type="gene ID" value="CP523_09860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60088">
        <property type="protein sequence ID" value="QAS60088"/>
        <property type="gene ID" value="EI377_04645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="22880" checksum="4E8BB1CDAAB8E2D9" modified="2018-12-05" version="1">MIFECCVGCYEDAKIAEKRGANRIELCDNLLEGGTTPSYGTIRAAVENINIPINVIIRPRGGNFTYTQDEKNIMYNDIKLCKDLGVNAIVIGSLTNDNKIDKEFVKKAKELAGILNITYHMAFDEISDKKTAIDELVELGIDRILTKGGNNSALENLDNLKELIVYAGDRITIIPGAGINSKNRDMVISYTGAKEVHGTKIVGELKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH77</accession>
    <name>A0A386PH77_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore maturation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08220</name>
        <name evidence="4" type="ORF">EI377_02970</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674705.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01586"/>
    <dbReference type="EnsemblBacteria" id="AYE34411">
        <property type="protein sequence ID" value="AYE34411"/>
        <property type="gene ID" value="CP523_08220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59816">
        <property type="protein sequence ID" value="QAS59816"/>
        <property type="gene ID" value="EI377_02970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="174" mass="19250" checksum="99C5EE3990C5EA55" modified="2018-12-05" version="1">MFNYLTQSVIPIIVIIIITYGMFKGRKVYEWFIEGAKEGLQVCLNIFPYLLAMIVAVHIFRESNLLDMLNNLIAPFSELIGLPKEVTPLVLVKPLSGSGAMGILTDILKTYGPDTSIGYIASVIMGTTETIFYTITVYFGAIQIKKIRHTIWASLFAEITAIIAAIFLVGALIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH78</accession>
    <name>A0A386PH78_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ORF">CP523_13910</name>
        <name evidence="16" type="ORF">EI377_08805</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678799.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00149"/>
    <dbReference type="EnsemblBacteria" id="AYE35433">
        <property type="protein sequence ID" value="AYE35433"/>
        <property type="gene ID" value="CP523_13910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60821">
        <property type="protein sequence ID" value="QAS60821"/>
        <property type="gene ID" value="EI377_08805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE35433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS60821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="32093" checksum="9894F47CC94212B3" modified="2018-12-05" version="1">MGLDLIYILKAIFIAIIEGLTEFVPVSSTGHMILFGSLIGFNSGNHVEFAKMFEVVIQLGAILAVVVLYWGKLWYSIVEFFTYIFTLGKKGEKGFRFGINVIIASIPAGVVGLLLHDKIKALFKPSAVVVAFIVGGVLLLVIENRFRNKVSKKGNISTTDVFDLTPMQSLKVGLFQVLSMWPGMSRSASTIMGGWIAGLSTPVAAEFSFFLAIPAMVGSTGLDLLKFDFSIMNKTYIIALIVGFVVAFIVSLVVMEMFVSYLKKKPMRVFAIYRIIAGIVLLILSVLGIVSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH80</accession>
    <name>A0A386PH80_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplB</name>
        <name evidence="8" type="ORF">CP523_08990</name>
        <name evidence="9" type="ORF">EI377_03735</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00238"/>
    <dbReference type="EnsemblBacteria" id="AYE34544">
        <property type="protein sequence ID" value="AYE34544"/>
        <property type="gene ID" value="CP523_08990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59944">
        <property type="protein sequence ID" value="QAS59944"/>
        <property type="gene ID" value="EI377_03735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="7">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="277" mass="30362" checksum="43EB322DD054F61C" modified="2018-12-05" version="1">MAVKKFRPTTPSRREMTMATFEEVTTSSPEKSLLVSLKKSGGRNAQGKITVRHHGGGAKRKYRIIDFKRNKDGIPAKVASVEYDPNRTAYIALVVYADGEKRYIIAPVGLKVGDVVVSGPEADIKAGNALPLRNIPVGTFVHNIELQAGKGAQMVRSAGTTAQLMAKEGNYATLRLPSGEMRYVRIECRATIGTVSNTTNDIINIGKAGRKRHMGWRPTVRGSVMNPCDHPHGGGEGRSPIGRPSPVTPWGKPALGYKTRKNKKYSDRFIIKRRNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH97</accession>
    <name>A0A386PH97_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33976">
        <property type="protein sequence ID" value="AYE33976"/>
        <property type="gene ID" value="CP523_05570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="77" mass="8705" checksum="9E036E54E076CF3F" modified="2018-12-05" version="1">MLLTLFRNKIPFAAPTTPSIGWLTNSKISFATPTSVSPIPNKKLIVTLFIVINSLFLFILSFQFFLFLSETLNFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB5</accession>
    <name>A0A386PHB5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34278">
        <property type="protein sequence ID" value="AYE34278"/>
        <property type="gene ID" value="CP523_07350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="102" mass="12357" checksum="700ED8867174C55A" modified="2018-12-05" version="1">MDNNRTKIIEFLQWNDRNGCYTDENCDLEDIPRMTYENAVKYFFGVMNDDFYYSITDNIFELSYDEVIKYAKDNNFYDSTYEKLNLLINNDKPTIEFYKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC4</accession>
    <name>A0A386PHC4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_03410</name>
        <name evidence="5" type="ORF">EI377_13935</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679090.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00057"/>
    <dbReference type="EnsemblBacteria" id="AYE33579">
        <property type="protein sequence ID" value="AYE33579"/>
        <property type="gene ID" value="CP523_03410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61743">
        <property type="protein sequence ID" value="QAS61743"/>
        <property type="gene ID" value="EI377_13935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="314" mass="35813" checksum="FAE82C8CB6A74668" modified="2018-12-05" version="1">MRIGLVLSGGGGKGAYELGVWKALKELEIDKYIDVFSGTSIGAFNAVLFAQDDMYAAEELWDEVTMDKLVPIGKFELFKKGFELAIGGKYLNIAKKYMLQKLEEGAVPKDGAKEIIDKYLDISRVKERKKICYAACTELPDFTAKYFKINDYDDKLAKEMVVASASLPLIYDCTEILGHKYIDGGVADNTPIQPVYGEGCDIIIVVLLSKESRIDRSLYPNTEIIELAPKKLDENVIKGTLNLDEESKRIRIREGYYDTIELLKPIMLMTELKVKIEEEKNYPILFKLYNWIKKKTKHWSKKTNYNNNKNTIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC7</accession>
    <name>A0A386PHC7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine/serine exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14280</name>
        <name evidence="8" type="ORF">EI377_09190</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676767.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02445"/>
    <dbReference type="EnsemblBacteria" id="AYE35505">
        <property type="protein sequence ID" value="AYE35505"/>
        <property type="gene ID" value="CP523_14280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60891">
        <property type="protein sequence ID" value="QAS60891"/>
        <property type="gene ID" value="EI377_09190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="153" mass="16917" checksum="1851B368CCE138DA" modified="2018-12-05" version="1">MISETLITFIATLGFGILFNIKGKKLFFAALGGAISWFTYLLGLHFYLTPLSALFISSIVFSLYSEIFARFLKTPVTTLVICSLIPLVPGGGMYYTMYEAITGNIMKSLETGLSTLARSGTLALGVIFVSTLTRLFVSAKRKREIKEYSRNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI7</accession>
    <name>A0A386PHI7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Signal peptidase I</fullName>
            <ecNumber evidence="4 7">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lepB</name>
        <name evidence="10" type="ORF">CP523_06070</name>
        <name evidence="11" type="ORF">EI377_00550</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675108.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01915"/>
    <dbReference type="EnsemblBacteria" id="AYE34066">
        <property type="protein sequence ID" value="AYE34066"/>
        <property type="gene ID" value="CP523_06070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59437">
        <property type="protein sequence ID" value="QAS59437"/>
        <property type="gene ID" value="EI377_00550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="9">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="176" mass="20305" checksum="5765DCC43AA68044" modified="2018-12-05" version="1">MENSSDKNKSRGFFYEWGIPIIVAVILALAINKYVVFKAYIPSESMVPTLNVDDRLFVTRVYNLDKLKRGDIVVFHSEELQEDLIKRLIGLPGDEVKIVEGEVFVNGEKLSEDYIGAHDKFNGEYKVPEGKYFFLGDNRLWSKDSRYWINPYIDGSEIKGKAQLKVYPFDQIGRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW3</accession>
    <name>A0A386PHW3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="12" type="ORF">CP523_06840</name>
        <name evidence="13" type="ORF">EI377_01315</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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                <person name="Seyboldt C."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="28909" checksum="3DE9218295F721D4" modified="2018-12-05" version="1">MSKEHEKYLKNVKRDKIKLAVVRMAILVIFIVLWEVAANLKWIDPFLTSSPSRIVRSFISFVNDGILPRHIWVTCYETILGFTLGTVLGAIIAVVLWACPFTSKVLDPYLVVLNALPKVALAPIVIFWVGNGTTAIIVIALLISIVTTIISVLTGFNEVDKGKLTLMKTLGATKIQTLRRLIFPSNLPVLISALKINVGLSWVGVIMGEFLVAREGLGFLIVYGGQISQLDMVMMSIVILSVIAFLMYKIVAVIENKLISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI11</accession>
    <name>A0A386PI11_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10025</name>
        <name evidence="3" type="ORF">EI377_04825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676561.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00334"/>
    <dbReference type="EnsemblBacteria" id="AYE34711">
        <property type="protein sequence ID" value="AYE34711"/>
        <property type="gene ID" value="CP523_10025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60112">
        <property type="protein sequence ID" value="QAS60112"/>
        <property type="gene ID" value="EI377_04825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="373" mass="41959" checksum="2FED564B42B556B0" modified="2018-12-05" version="1">MKIGIDGRAAKWYRGTGIGTYTYQLINNLSKIDAENNYSIFLPEGSPLNLGDNFKIESLKSASNDNFWEEVKVPNILKDNNMNLYHVPQNGVGLSNNISCLKTITLHDIIPLKMPETVSDRYLNIFNNQLPNIINNSQGILTVSEFSKQDIAKEFNFPKDKIFVTHLAAEDIYKPLNKNNCKKIIAKKYGIDKDFILYVGGFSPRKNIIGIIEAFSLLKINFKKDLKLVITGKKGISYERYKKRADDLGLNDSVIFTGFIPLNDLPIFYNASKLLVYPSFYEGFGLPPLEAMACGTPVIASDVTSLPEICGDSAILIDPYNIYDISYYIENILSDSDLKNNLIKKGLLKSSHYSWKNTAIDTITAYNDIIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI12</accession>
    <name>A0A386PI12_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation:dicarboxylase symporter family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Sodium:dicarboxylate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_07160</name>
        <name evidence="9" type="ORF">EI377_01915</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01047"/>
    <dbReference type="EnsemblBacteria" id="AYE34246">
        <property type="protein sequence ID" value="AYE34246"/>
        <property type="gene ID" value="CP523_07160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59652">
        <property type="protein sequence ID" value="QAS59652"/>
        <property type="gene ID" value="EI377_01915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="459" mass="49336" checksum="327CD304F42B8D15" modified="2018-12-05" version="1">MNTTFLSEFLMITNFKTILLMLLLIGVFFIVRKVEKKNTQFSTRMILATILGLGLGTLIQVLAGFPDNPTKVQWINEVIKWYGLIGNGFMDLLKMLVVPLVFISIIRVIINMKKGENLGKLTIRSVLVLLGTTTIAAIIGIIIGNLFKLGVGLEIVEAKTDIKEIKSIVDTLRGLIPSNPVQAMAEGNVVAVVIFAGFIGFAMQRLKNNFHQEIKPAIDLVEASYKIITKVALTVIRFMPYAVIPLLSNTIAGRGLSSIISVINFILALYVSVAIMFVIHLIIITLNGLNPIKYIKNVSEPLILAFTSRSSVGTLPVTIETLSDKVGLEKGIASFVASLGANAGMNGCAAIYPALMVVTIANISGTEMNFSFYIMLVVIIAISSLGIAGLPGTATMSVSVVISGMGMGGYFPLIGGILAIDPILDMGRTMLNVNGSMVTAATVANSFNEIDREVFNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI31</accession>
    <name>A0A386PI31_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07205</name>
        <name evidence="3" type="ORF">EI377_01960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673732.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01058"/>
    <dbReference type="EnsemblBacteria" id="AYE34252">
        <property type="protein sequence ID" value="AYE34252"/>
        <property type="gene ID" value="CP523_07205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59658">
        <property type="protein sequence ID" value="QAS59658"/>
        <property type="gene ID" value="EI377_01960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="495" mass="57749" checksum="478A86D35B749B95" modified="2018-12-05" version="1">MARKIKILTNEGLKSDNQKIDRRKLGYYYTPKFVGEYIALRMTSFHIGNRVLDPCCGKEELLSVFISNKMDIDGMDIIKYKEKYNCNFYNDNFIDYYCNRKKSNKLELNYDYYIANPPYNCHEVDFIKKNKSVLKPYFNDVGVHNMYSMFISAIIDFAKPNSVIGLITHDSFLTAKYHESLRKKIIAECAIHEITMCPTDLFLNQDADVRTSIIILQKGKENQGKIIVNNRPKNTEELRKILKSNLNKKYEKKYLLKDIVLQDLKDNSEFIIECPDDIRRLFNGKRLGDFYKCITGISTGNDKVYLSRDKKDPYTIPFYKNPGKDKFYTNKNIYLHKNFLKFDKEIKNFIVRNKDFLYEPGIICSSMGVDFTACKFPKNSTFGVNTNIICTENDSWWLLAYLNCKLVTYIVRGILIRSNMITSGYVSRIPMIKFSVKEKEQLSYLAKEAYYGVLNKKDIKNITDEIDSIVNKAAKISSKTINFIGLFKDDLIRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL5</accession>
    <name>A0A386PIL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIM</name>
        <name evidence="2" type="ORF">CP523_15140</name>
        <name evidence="3" type="ORF">EI377_10095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679005.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00100"/>
    <dbReference type="EnsemblBacteria" id="AYE35660">
        <property type="protein sequence ID" value="AYE35660"/>
        <property type="gene ID" value="CP523_15140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61046">
        <property type="protein sequence ID" value="QAS61046"/>
        <property type="gene ID" value="EI377_10095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014196">
        <property type="entry name" value="SpoIIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038973">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02831">
        <property type="entry name" value="spo_II_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="23693" checksum="CCDA626DD5249648" modified="2018-12-05" version="1">MNIISRLNSNLKENKVLYILVLIFFFVGIILGSYVVRYMSGGDAKDLSSYFTSFITSLGEKPIDKATLIFDILKKNLLLIIIILALGFTVFGTPFILIIDLIKGFTLGYTFSFLLTTFEGKGIWIALASTLPQNILYIPFFIGISIISLEISSRKLKEHFFNGNKVNRIVTNQLLMKLSIFISIFVIGAIVETYISPSLIKIIVAKVYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL8</accession>
    <name>A0A386PIL8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ORF">CP523_11580</name>
        <name evidence="9" type="ORF">EI377_06395</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02874"/>
    <dbReference type="EnsemblBacteria" id="AYE35004">
        <property type="protein sequence ID" value="AYE35004"/>
        <property type="gene ID" value="CP523_11580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60397">
        <property type="protein sequence ID" value="QAS60397"/>
        <property type="gene ID" value="EI377_06395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="490" mass="57282" checksum="8C83FB2F8DE2B095" modified="2018-12-05" version="1">MKRSSGILMHISSLPGDYGIGTLGVEAYKFVDFLKKSGQRYWQILPLGQTGYGDSPYQCVSAFAGNPYFIDFDLLKEDGLLKEEDYKNEYFGKDNNCIDYGTLFINKTKVLKKAYKNYNLISEKINEFRNSNKYWLENYTLYMAVKEHFNLISWQNWDENIRLRKDESIEKYKKELKDDIKYWEFIQYIFFKQWNSLKKYANDSGIKIIGDIPIYVAVDSADIWSNPKYFKVDKNMIPTKVAGCPPDLFSETGQLWGNPIYNWELMEQDGYKWWIKRIEDSFKIYDVVRIDHFRGFESYWEVPYGEKTAINGRWVKGPGIKLFHTIKRELGEVNIIAEDLGLLTDEVVKFRNQTGFPGMKVLQFAFGGGDVYLPHNYEKNCVVYTGTHDNDTICGWYNETATEEEVEFANKYLALNYKEGIAFGFIRGIFSSVGNLAIATMQDFLSLGNEARMNFPSTLGGNWKWRIRKYELTDELSQKILELTKRYGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP2</accession>
    <name>A0A386PIP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08875</name>
        <name evidence="2" type="ORF">EI377_03630</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678117.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02715"/>
    <dbReference type="EnsemblBacteria" id="AYE34522">
        <property type="protein sequence ID" value="AYE34522"/>
        <property type="gene ID" value="CP523_08875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59924">
        <property type="protein sequence ID" value="QAS59924"/>
        <property type="gene ID" value="EI377_03630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34547">
        <property type="entry name" value="PTHR34547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="170" mass="19721" checksum="46A63602F05E290E" modified="2018-12-05" version="1">MKIIFVDGYNVVNSWPNLKSEKEHNFQGTRQNLIDILHNYGVYNDCKIVIVFDAHKVSGSIEKKEFINKNISVVFTKDGETADAYIEREVHSLGRKFEVYVVTSDWLEQQTIFQRGAIRISALEFYNDIIQTELRINNKAKKNITDNKNHLGDNVNSEVLIKLEAMRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ3</accession>
    <name>A0A386PIQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10290</name>
        <name evidence="2" type="ORF">EI377_05070</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674301.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01437"/>
    <dbReference type="EnsemblBacteria" id="AYE34758">
        <property type="protein sequence ID" value="AYE34758"/>
        <property type="gene ID" value="CP523_10290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60158">
        <property type="protein sequence ID" value="QAS60158"/>
        <property type="gene ID" value="EI377_05070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="338" mass="39651" checksum="0466FB18D132CF8F" modified="2018-12-05" version="1">MGYEKIINYKEFNDCLTRINKWYLKKSKILNIVTSPYNSTLIYSSIIIEVIRKGGNVLYIWENNSSNNELIKDIKLKNSNITYSYIEKGESKSNIVFSSFKNMIDIRGKYDLCIIDDISNFSLMNSDELIELIEAMYIYSNRIIIYSIERIVSMGEKIEICSLVSNKPHIEPRILNTRIKLEEDIPYSLYDYLLWFRDTKRKVIIYAPTEEKAKNVYKQYTDKLKISGAKFILLLRNDSLKELESSLKTKEKSLFLITSHFGEYLKRLQDVSVVVLFADNVYYSYKKLIYLCGKVGENDKNPGEILLVSREISNDMEEAKNFSRGLNKKIWEKGLLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ07</accession>
    <name>A0A386PJ07_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00001"/>
    <dbReference type="EnsemblBacteria" id="AYE35427">
        <property type="protein sequence ID" value="AYE35427"/>
        <property type="gene ID" value="CP523_13880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011202">
        <property type="entry name" value="UCP014677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014677">
        <property type="entry name" value="UCP014677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="2">
        <location>
            <begin position="159"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="536" mass="63760" checksum="3605283E73AA63B1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ10</accession>
    <name>A0A386PJ10_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12380</name>
        <name evidence="3" type="ORF">EI377_07265</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675351.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35151">
        <property type="protein sequence ID" value="AYE35151"/>
        <property type="gene ID" value="CP523_12380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60554">
        <property type="protein sequence ID" value="QAS60554"/>
        <property type="gene ID" value="EI377_07265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="162" mass="18567" checksum="B676F27131711D0D" modified="2018-12-05" version="1">MKFISKIISNIITVAYGVVCMPLLVLIAIFLPVFTIVEAFKIISTGYTVSTEYISMILAMSIIMYFSLRFRALRRIYKVFPSLFEALKYLVIAGIFIGVGAELLNWSYITLTPGRKIFGIASFIASLILWRVFASIYYRKKPLSKIMLESTEKMQNYNEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ19</accession>
    <name>A0A386PJ19_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09250</name>
        <name evidence="4" type="ORF">EI377_03995</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678318.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03048"/>
    <dbReference type="EnsemblBacteria" id="AYE34596">
        <property type="protein sequence ID" value="AYE34596"/>
        <property type="gene ID" value="CP523_09250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59996">
        <property type="protein sequence ID" value="QAS59996"/>
        <property type="gene ID" value="EI377_03995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788415" evidence="1">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_2" evidence="2">
        <location>
            <begin position="92"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="195" mass="22059" checksum="76DC259BF1894EE7" modified="2018-12-05" version="1">MKYLKHLFIFFLTLSFSVNIITSTLACKMLDDTTSSINTLAKDENLKQDNNNTFIDAPNNVVEVFNHNNNLIYLTEEDLNLMAKIVYAESKGEPYEGKVAVASVILNRVLDQSFPNTVKEVIFQPYAFSCVVNGEIPGDPNKECFNAVYDAIKGNDPTNEALFFYNPTISTCTWMENIQKNDSKTIGQHLFFKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ92</accession>
    <name>A0A386PJ92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678225.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03029"/>
    <dbReference type="EnsemblBacteria" id="AYE35251">
        <property type="protein sequence ID" value="AYE35251"/>
        <property type="gene ID" value="CP523_12915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="231" mass="26512" checksum="7944DFFB904185CE" modified="2018-12-05" version="1">MYTKGDFHLHTTKSDGDHTPTEIVKMAKKQGLDIISITDHNTTAGIAEAKKIGTALGVKIIPGLELSTRYKGRKIHVLGYFLDDKYKNKNFQKGLKYIKSHNTQALQKLMKGKILVSKDDEKNRIDVRTGVDFLRFFGATIVLAHPVKIKPVMFREIINLDFNGIEAIYFKNKPEETEYFKKIAEDRDMFYTAGSDFHTNKTLDKRHGLIGDVYLNKEEIERFLKALEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJA4</accession>
    <name>A0A386PJA4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DMT family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">EamA family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07175</name>
        <name evidence="5" type="ORF">EI377_01930</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01050"/>
    <dbReference type="EnsemblBacteria" id="AYE34249">
        <property type="protein sequence ID" value="AYE34249"/>
        <property type="gene ID" value="CP523_07175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59655">
        <property type="protein sequence ID" value="QAS59655"/>
        <property type="gene ID" value="EI377_01930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="167"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="325" mass="34654" checksum="2ADB2E6F465D56FB" modified="2018-12-05" version="1">MKNKKNKFALGIIFGIIVGIAWGLDGVLMGQLGGNSIFEGFELSPLVTALFHDGFCFFWIALALIFSKQLKGAFSLLKTKKGMVTIVAAIVGAPIGMSAYLLAIKYAGAPYASSISVIYPGVGAVLSYFILREKLSLRSVVEIAISLFGSFMLGFNPSADMPEKFFTGVLFALVAVAGWALEGVIIGFAMRKVKGEDHIKATPQQFLCVRYLTSLLAYALIVVPVIGGYKVAGDIVSNGLVFKYAGIAILGAITYLAWYKAVDLIGAAMGTALNSTASLWSIIFSAVLFGVNITPKLAFWGTIIVVGVFVFAIDPKKLSTKKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJC5</accession>
    <name>A0A386PJC5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0237 protein CP523_13410</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13410</name>
        <name evidence="4" type="ORF">EI377_08300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0237 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677545.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00777"/>
    <dbReference type="EnsemblBacteria" id="AYE35344">
        <property type="protein sequence ID" value="AYE35344"/>
        <property type="gene ID" value="CP523_13410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60735">
        <property type="protein sequence ID" value="QAS60735"/>
        <property type="gene ID" value="EI377_08300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04872">
        <property type="entry name" value="ACT_1ZPV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01054">
        <property type="entry name" value="UPF0237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022986">
        <property type="entry name" value="UPF0237_ACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="9856" checksum="4CC983EC3F31C966" modified="2018-12-05" version="1">MKAILTVIGKDRVGIVAGISNELLNQNINILDVNQTIMEEYFTMIMMLDLGKANGTFDDAKKALLSKGEELGVDVKIQRAEIFNSMHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE8</accession>
    <name>A0A386PJE8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11835</name>
        <name evidence="3" type="ORF">EI377_06655</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02925"/>
    <dbReference type="EnsemblBacteria" id="AYE35048">
        <property type="protein sequence ID" value="AYE35048"/>
        <property type="gene ID" value="CP523_11835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60441">
        <property type="protein sequence ID" value="QAS60441"/>
        <property type="gene ID" value="EI377_06655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="415" mass="48492" checksum="559F42823D4D0535" modified="2018-12-05" version="1">MRNINKIGIKVEKYIISLKEDLSNLNKEKLGEFFLKRRFLLISIFTIALFGIFSFNFFMTSKNELINDLEISLKEGKVYRISRKIRVLEERPSKKELTPLVNYYNYDLTKIDGVIKDLRNTNKGGVFTLKENNFLFFENYYLEIIPVSIKVNTDFDSTKIYLNDNLLKDNNSKKGVIPGMYKVKGELETPYGKVSKEEEVSLMQNEEISLKLDAMNITLSSNFDDAKVYINDKDTGKIVKDIKDFGPIPTNLDTYISLEKNFPWGIIKSDKLKVSDLPNINIKINMVNDTLEKNIQEVVKRFYESVFLALNSRDKSLIVLTNDDIKERIYENIEKKTLILKNNYEISELKTNIESSEFKYQDDVYTAKIVVKVEYDVSKKFIPVYTKKHEDMFLTTMKYTGNEWIIEGVQKFNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJH9</accession>
    <name>A0A386PJH9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">CP523_10585</name>
        <name evidence="4" type="ORF">EI377_05370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674177.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01384"/>
    <dbReference type="EnsemblBacteria" id="AYE34812">
        <property type="protein sequence ID" value="AYE34812"/>
        <property type="gene ID" value="CP523_10585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60206">
        <property type="protein sequence ID" value="QAS60206"/>
        <property type="gene ID" value="EI377_05370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="339" mass="36040" checksum="B32E81AE7BEEC56F" modified="2018-12-05" version="1">MGFFSSNKDMGIDLGTANTLVYVKGKGIVLSEPSVVAINSATRKPLAVGAEAKLMIGRTPGNIVAIRPLKDGVIADFDVAQTMLKKLIEKVISKSAFTSPRIIVCYPSGVTEVERRAIEEATKNAGARDVVLMEEPMAAAIGAGLPVGEPTGSMIVDIGGGTTEVAIISLGGIVTSKSLRVAGDELDQSIIAYIKKEFNLMIGERTAEQVKMELGSAYKIDDEVKEMDIKGRDMVTGLPKTVTVSEDQIREALKEPVYAIIESIKTTLEKTPPELAADIMEKGIMLAGGGALLKGLDMLINHETNMPVHIAETPLDCVVLGAGKALDNFDELSKTQRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI6</accession>
    <name>A0A386PJI6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2344 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10640</name>
        <name evidence="3" type="ORF">EI377_05425</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674157.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01374"/>
    <dbReference type="EnsemblBacteria" id="AYE34822">
        <property type="protein sequence ID" value="AYE34822"/>
        <property type="gene ID" value="CP523_10640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60217">
        <property type="protein sequence ID" value="QAS60217"/>
        <property type="gene ID" value="EI377_05425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="26720" checksum="9B4F59F809B7551D" modified="2018-12-05" version="1">MRYVIKFTKESSIKFISHLDLMRTIQKVIRRADLPMQYSKGFNPHMALSIAQPLSVGVYSEAEYMDIVLVEELDENEIIDRLNEKTAQGIKFISAHKVINVDGEKKLPQSMALVDAARFTVKMLCDKSEEVSSKMESLLGEEKWITIKKSKKGEKEVDLKTMIKGFKYWVKDNEIIINMLISSGSREHLSPDLVASYIKGKISNIIEDAFVDIKREEMYVLKGKNYVALYKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJK2</accession>
    <name>A0A386PJK2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfkA</name>
        <name evidence="12" type="ORF">CP523_13915</name>
        <name evidence="13" type="ORF">EI377_08810</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678801.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00150"/>
    <dbReference type="EnsemblBacteria" id="AYE35434">
        <property type="protein sequence ID" value="AYE35434"/>
        <property type="gene ID" value="CP523_13915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60822">
        <property type="protein sequence ID" value="QAS60822"/>
        <property type="gene ID" value="EI377_08810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13915"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="7"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="366" mass="39365" checksum="E9365E33BFB47890" modified="2018-12-05" version="1">MAQQVKKIALLTGGGDCPGLNAVIRAVTRTAILNYGIEVIGYKFGYRGLYNNDYVPLTLDSVSGILHRGGTILYSSNKDNLFDYQIEEDGIIVKKDVSDVAVENLKKEGVDVLVVIGGDGTLTSARDFARKGINVIGVPKTIDNDLASTDVTFGFNTAIDVATEALDRLHTTAESHHRIMICEVMGRGAGWIALESGIAGSADVILLPELPYDINKIVEKIEERESQGKRFSIIVVAEGAKPKNGDVVVSKIVKDSPDPIRLGGIGNKLADDLEKLVPDKEVRCTVLGHIQRGGNTSTFDRILSTRYGVAAVELINQGKFGEMVCLKGNKISSDSLENVIGQKSKLVNPEGELVQIAKKIGISFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJM2</accession>
    <name>A0A386PJM2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03075"/>
    <dbReference type="EnsemblBacteria" id="AYE35697">
        <property type="protein sequence ID" value="AYE35697"/>
        <property type="gene ID" value="CP523_15355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1363" mass="148923" checksum="5F14876427172FB8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP7</accession>
    <name>A0A386PJP7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ethanolamine utilization protein EutN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12465</name>
        <name evidence="2" type="ORF">EI377_07350</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675322.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02020"/>
    <dbReference type="EnsemblBacteria" id="AYE35168">
        <property type="protein sequence ID" value="AYE35168"/>
        <property type="gene ID" value="CP523_12465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60571">
        <property type="protein sequence ID" value="QAS60571"/>
        <property type="gene ID" value="EI377_07350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01614">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036677">
        <property type="entry name" value="EutN_CcmL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36539">
        <property type="entry name" value="PTHR36539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="9304" checksum="BF766CC24B6D2C85" modified="2018-12-05" version="1">MLVARLVHNVWATRKADSLTGLKFMLAEEISDKGEGNRFVVVDIIGAGVGDRVIISTGSSARKMLGDDNIPVDAVVVGIIDNDCTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJQ9</accession>
    <name>A0A386PJQ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14225</name>
        <name evidence="3" type="ORF">EI377_09130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678499.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00277"/>
    <dbReference type="EnsemblBacteria" id="AYE35494">
        <property type="protein sequence ID" value="AYE35494"/>
        <property type="gene ID" value="CP523_14225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60880">
        <property type="protein sequence ID" value="QAS60880"/>
        <property type="gene ID" value="EI377_09130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="199" mass="22181" checksum="F5BB09EA358F2DD0" modified="2018-12-05" version="1">MIIKTIPAGSLQANCYIVMDEDTKEAVVMDPGGDSDWIIKTIESIGAKIKYILLTHAHADHDGGVVDLKKKYDVPVYMNKAEEEYMEKDNFVFGRIPKFYSFINDGDILKIGSLEIKCLHTPGHTKGGMCFLIEDKVFTGDTLFQGSIGRTDFSGGDFNEIIKSINDKLLVLPNNVEVYPGHGPKSTIIFEKMRNPFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJY1</accession>
    <name>A0A386PJY1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactose/methyl galactoside ABC transporter permease MglC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mglC</name>
        <name evidence="7" type="ORF">CP523_14725</name>
        <name evidence="8" type="ORF">EI377_09685</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676142.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01340"/>
    <dbReference type="EnsemblBacteria" id="AYE35584">
        <property type="protein sequence ID" value="AYE35584"/>
        <property type="gene ID" value="CP523_14725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60969">
        <property type="protein sequence ID" value="QAS60969"/>
        <property type="gene ID" value="EI377_09685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030158">
        <property type="entry name" value="MglC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF18">
        <property type="entry name" value="PTHR32196:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="36423" checksum="2C446E1F9FB04E6C" modified="2018-12-05" version="1">MENTKFDKKKLENFLLNYALYIVLFMMIIFFVYKEPGFLSLKNFTNILSQASTRGILALGVAGLIVLQGTDLSAGRILGLTAIVSASLLQSTTYAARMYPDLPQLPLILPLIAAIIIGAIFGAINGFGVAKLKVHAFIITLGTQLIAYGASCLYIDRPPLGAQPVANLDARYTNFVTGSLNLGAVEIPYLIFYLAIVALIMWFIWNKTKLGKNMFAIGGNPEAAAVSGVNLVKNIMIIFVISGVLYGLAGFLEAARAGSTTTATGFNYELDAISACVVGGVSFTGGVGTIPGVLIGTVLLQVINYGLNFIGVNAYWQYIIRGLIIIVAVSLDVRKYIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK25</accession>
    <name>A0A386PK25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class II aldolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11675</name>
        <name evidence="5" type="ORF">EI377_06495</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02894"/>
    <dbReference type="EnsemblBacteria" id="AYE35022">
        <property type="protein sequence ID" value="AYE35022"/>
        <property type="gene ID" value="CP523_11675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60416">
        <property type="protein sequence ID" value="QAS60416"/>
        <property type="gene ID" value="EI377_06495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="30726" checksum="2B10754474D038C3" modified="2018-12-05" version="1">MSLVKITDLLSKAKEENYAVGSFSVSNMEMIIGALKAAEETNSPIIFQIAESRLLNSPLDLIGPLMISAAKNAKVPVAVHFDHGTTVVNIKKALELGFTSVMIDGSHLSFDENVKITKIVKNLANRYGADVEAEIGQVGGSEDGSEDIQMKVTSIKDAKRFVEETKVDALAVAIGNSHGVYKGTPKLRFDVLEELSKNIEIPLVLHGGSGITNGDFKKCKNKGIRKINIATATFNSVEESVRELYLNNEKKNYFILQEAEVQGAYKNIKNHIEIFESINKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK95</accession>
    <name>A0A386PK95_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnQ</name>
        <name evidence="9" type="ORF">CP523_12230</name>
        <name evidence="10" type="ORF">EI377_07050</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673578.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35122">
        <property type="protein sequence ID" value="AYE35122"/>
        <property type="gene ID" value="CP523_12230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60513">
        <property type="protein sequence ID" value="QAS60513"/>
        <property type="gene ID" value="EI377_07050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="449" mass="47950" checksum="F548CB5D7E605197" modified="2018-12-05" version="1">MKNLSKKDLLLVSLMLFSLFFGAGNLIFPPFLGQSAGGSTIVAMLGFFVTAVGFPVLGVVVIAKAGGLYALAKRVNKIFAGIFTVLIYLSIGPGLGIPRAGSLPFEMAVAPYLPSSISKVFALFMFTLVFFTVAYWLSLSPSKLVDRMGKVLTPTLLVLVALIFIAAIFKPLGGYGEATGEYMTSPLIKGFLEGYLTMDTIAALNFGIVISLAIKSRGIDDEKVVISTSVKAGLIAGFLLILIYSMLAHLGATSGARFGATENGAQTLTNVMTYIFGKPGAVLLAVVFTLACLTTCVGLITSCSQYFTTLTNKVKYKTWVTILSLSSMILANMGLTKILSISVPVLNAIYPVAIMLIVLGTIHNFFRGSTIVYFTTILFTAVVSVVDALEQVGITMGVVNKLFDKLPFYSQGLGWMIPALVGLLLGIVLKEVKGKVGENKNIQTTNNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKB3</accession>
    <name>A0A386PKB3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12385</name>
        <name evidence="4" type="ORF">EI377_07270</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675350.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35152">
        <property type="protein sequence ID" value="AYE35152"/>
        <property type="gene ID" value="CP523_12385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60555">
        <property type="protein sequence ID" value="QAS60555"/>
        <property type="gene ID" value="EI377_07270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="236" mass="26869" checksum="7501997FDFE5F207" modified="2018-12-05" version="1">MKKFRENELTDFEELNDVRVNSEKEEEEINLDKMVESKNEDIQVNKVSEPKEENSYKRFDEEKEEKEEKDDYITPSMKRFRTSIGIICLVLVVAVGIFHKKVNEAYRDNLTSGYLENVNAGDILSKEALKLDAKDESIEVANGYGNLEISIWNFSKVEDNDYVQVFIDGVAQGGPFSIRHKPIKISVPDKAVIQVQGVRDGSNNGITYAVHFNKTGETYLNTVSLNAKNSYTIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKJ9</accession>
    <name>A0A386PKJ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein FlgN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02710</name>
        <name evidence="2" type="ORF">EI377_13235</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677027.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00948"/>
    <dbReference type="EnsemblBacteria" id="AYE35804">
        <property type="protein sequence ID" value="AYE35804"/>
        <property type="gene ID" value="CP523_02710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62221">
        <property type="protein sequence ID" value="QAS62221"/>
        <property type="gene ID" value="EI377_13235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036679">
        <property type="entry name" value="FlgN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140566">
        <property type="entry name" value="SSF140566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="16088" checksum="6167801D15BE74F7" modified="2018-12-05" version="1">MVDLLIEVLVKEKESLNQLLGLLDKQYKLIMDKDIFGLEQIVEDIQYCNKEVAVLEIERRKVLNENTISEILENIENENLENIYREIQKMLNEVILQKNTNELLIKQQLSFTNKLLAILNPRREVPIYNSYGNIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKN4</accession>
    <name>A0A386PKN4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11770</name>
        <name evidence="3" type="ORF">EI377_06590</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02913"/>
    <dbReference type="EnsemblBacteria" id="AYE35861">
        <property type="protein sequence ID" value="AYE35861"/>
        <property type="gene ID" value="CP523_11770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62168">
        <property type="protein sequence ID" value="QAS62168"/>
        <property type="gene ID" value="EI377_06590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="193" mass="20650" checksum="C349A0140F0733F5" modified="2018-12-05" version="1">MGKSKSHVRKMVMIAMLSGISIFLGVSGLGFITLPIFRLTIMHVPVIIGAILEGPIVGATVGLMFGLFSMYQNFTAPTLTSFVFYNPIIALVPRILIGIVAYYIYKLLKNIIKNQSISIGISAVLATLTNTIGVLGLTYILYLEQYAAAREISTSAVSGTLLAIGISNGIPEAIVSSLITIPVVIGILKIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKQ2</accession>
    <name>A0A386PKQ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_09975</name>
        <name evidence="12" type="ORF">EI377_04760</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676653.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00324"/>
    <dbReference type="EnsemblBacteria" id="AYE35854">
        <property type="protein sequence ID" value="AYE35854"/>
        <property type="gene ID" value="CP523_09975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62161">
        <property type="protein sequence ID" value="QAS62161"/>
        <property type="gene ID" value="EI377_04760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033869294" description="FAD:protein FMN transferase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS62161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="337" mass="36844" checksum="23BA27416164AC53" modified="2018-12-05" version="1">MSLSILIVFTLLSITGCSKKTSSPISRSEILMGTIIKVTIFDSSNEKVLDEVFNKIKELESTLSINANGTLIDKINESAGVAPVKVDDDTYNLISKGIEYSNLSNGLFDISIGPLVKLWSIGLPEAKVPSKEEINEKLPLIDFNNIELNDTNKTIFLKKSGMLLDLGGIAKGYTADKISDILAENNIKNALIDLGGNIYTHGTKITGDDWKVGIQDPFSERGEIIGSITISNKSIVTSGIYERFIEKDGIKYHHILSPETGYPYDNDLAGITIISNKSIDGDALSTSVFAMGLKDGINFVEKLENIEAIFVTKDKRVHITSGLKDNFVITNESFVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKQ5</accession>
    <name>A0A386PKQ5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdaAB</name>
        <name evidence="11" type="ORF">CP523_10830</name>
        <name evidence="12" type="ORF">EI377_05615</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02500"/>
    <dbReference type="EnsemblBacteria" id="AYE34859">
        <property type="protein sequence ID" value="AYE34859"/>
        <property type="gene ID" value="CP523_10830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60253">
        <property type="protein sequence ID" value="QAS60253"/>
        <property type="gene ID" value="EI377_05615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10830"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="149"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="24471" checksum="1822C6489A080F1F" modified="2018-12-05" version="1">MKDVGVFDIMGPIMIGPSSSHTAGAARLGKVARAVSEGDIKEVRFLLHGSFGKTYKGHGTDRALVAGILGMEPSDIRLRDAIEIAEKQGIKVSFEEADLGDAHPNTVKILIKGKKEEKYEIIGSSIGGGSIQISEVNGNNVEFTGAYPTLIISHMDIPGAVSKVTAILYKDDINIAFMKVFRSQKGKEATMVFEVDHSMPKEMIEEIKKIDSIKKVIMINPAKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL76</accession>
    <name>A0A386PL76_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02050</name>
        <name evidence="8" type="ORF">EI377_12570</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678898.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00122"/>
    <dbReference type="EnsemblBacteria" id="AYE35798">
        <property type="protein sequence ID" value="AYE35798"/>
        <property type="gene ID" value="CP523_02050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62218">
        <property type="protein sequence ID" value="QAS62218"/>
        <property type="gene ID" value="EI377_12570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="283" mass="31803" checksum="0EAFAB8A1B5A315F" modified="2018-12-05" version="1">MNKIKNQNNGLEASPFAIWSALFIVIPLFIVLFFGFTIKTPEDGYTFSIENFTRLLQPQYIKVFTRSLSLALSATIGCLVLGYPVAYIISKMTPSKRNILIMLFIVPMWMNFLLRTYAWLPILGKNGFINNILSHFGIGPFTFLYNDGAVILGMIYNFLPFMVLPIYTVLTKMDQNLINAASDLGANKKQIFRKIVLPLSMPGVISGITMVFMPAVSTFVISRLLGGGQYMLIGNLIEQQFTTMGDWNFGSSISIFMMIIILISMAIMNKFDSSNKEEGGQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL78</accession>
    <name>A0A386PL78_CLOSE</name>
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        <submittedName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12215</name>
        <name evidence="6" type="ORF">EI377_07035</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02998"/>
    <dbReference type="EnsemblBacteria" id="AYE35119">
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        <property type="gene ID" value="CP523_12215"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60510"/>
        <property type="gene ID" value="EI377_07035"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="69" mass="7735" checksum="2C22258C25916E71" modified="2018-12-05" version="1">MSSRTGIVKWFNTEKGYGFISCDDGNDVFVHHSQIKEKGPEKDLQESQNVSFDVEEGPKGPMATNVQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLE6</accession>
    <name>A0A386PLE6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II/IV secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14955</name>
        <name evidence="4" type="ORF">EI377_09910</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01293"/>
    <dbReference type="EnsemblBacteria" id="AYE35888">
        <property type="protein sequence ID" value="AYE35888"/>
        <property type="gene ID" value="CP523_14955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61012">
        <property type="protein sequence ID" value="QAS61012"/>
        <property type="gene ID" value="EI377_09910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="465" mass="53719" checksum="3100B2398B0855CA" modified="2018-12-05" version="1">MNVKENNMFINKLNLNISRKINKQFALENKVIPLYREENLIVALAKKESEEIKRELNFIFNSEIKFILIEEKIIYSIIEKTFSGENDDLELDILKKAIDLSASDIHMEPRGSEVVIRFRVDGILFMERKIKNNEYNILLSKIKIKANVDITEKRRPQDGKYSITLNEKEYSLRISTIPIIYGEKLVIRILYGKVLNYSMDSLNLNIKQLEKLKKIMSLKNGLFIATGPTGSGKSTTLYAMLQYINNDEINITTLEDPIETIIPGINQMNLNRKANINFANGLRNVLRQDPDTIMVGEIRDEETAEIAISAALTGHKVYSTIHSKTPREVYLRLEDMGVKSYLIRDSLVGIISQRLIRILCNKCKVISEKKIVNNEEINLYESCGCIECNNTGYKGRKMVASICIIDDDIKRVYSNIFQEINYLNNDEMLDSLEELLKLGDITKVDFKNFIMMEGLNESKYRRYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLH9</accession>
    <name>A0A386PLH9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15585</name>
        <name evidence="2" type="ORF">EI377_10300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678688.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35742">
        <property type="protein sequence ID" value="AYE35742"/>
        <property type="gene ID" value="CP523_15585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61081">
        <property type="protein sequence ID" value="QAS61081"/>
        <property type="gene ID" value="EI377_10300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="313" mass="35627" checksum="2CF067A0ACB74B72" modified="2018-12-05" version="1">MDNNLLDLFIYMDESLIKNMNALALNGYIDIKTVTNIKDRTLSGNINISNREACGNGEKQGKDKTDGYKVRHHFLDNNYQNTKGIDGGVEGKEYDRIQEQFQRINTTFLLHNELVSSLYDNNNIKLIESENIVEEDLTEGEIIEVQGEITTLSIVPYLNTLINTLICYNTEFLDSLLKDSKLKGLNYTVIVKLLECMKNCITENGTEEMVLSNGKSYIILVVNNTYFLNSKACMYDFTSCPCRVIGKTMKICCSNEKLSLFRKSSQEEYYEKLLKSMDPYFDILEKNGILLPNKPDISIKGKATVMLPISICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLK6</accession>
    <name>A0A386PLK6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2953 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15185</name>
        <name evidence="3" type="ORF">EI377_10140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678589.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35666">
        <property type="protein sequence ID" value="AYE35666"/>
        <property type="gene ID" value="CP523_15185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61053">
        <property type="protein sequence ID" value="QAS61053"/>
        <property type="gene ID" value="EI377_10140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021338">
        <property type="entry name" value="DUF2953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11167">
        <property type="entry name" value="DUF2953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="192" mass="22509" checksum="DF43C7F13385481D" modified="2018-12-05" version="1">MVISIIILLIILIFLLPIPLKITLYRNKKYFHIKIFNIVLLSPEKGVLNDLLKKSNKKNSKTSFNENNRNKNILFKRKNKKLSLISLYHSIVNNRFKPWFKLNGKIDFALDDAAYTAIGYGLLCNLHPILYGILKQAFLVKKFKLEINPHFNEDKILNFTIYSIIYFNLAHAIYILYLIYNSFENVEEVAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLQ1</accession>
    <name>A0A386PLQ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_09335</name>
        <name evidence="6" type="ORF">EI377_04080</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678053.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02724"/>
    <dbReference type="EnsemblBacteria" id="AYE35852">
        <property type="protein sequence ID" value="AYE35852"/>
        <property type="gene ID" value="CP523_09335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62159">
        <property type="protein sequence ID" value="QAS62159"/>
        <property type="gene ID" value="EI377_04080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="24544" checksum="7D2A69D0BD4E7262" modified="2018-12-05" version="1">MVSCSNVRKIFNVGDLQTEILKGITLSINEGEFVAVVGESGSGKSTFLNILGGLMSADKGEININGVKVDKLNENQLALFRRDNMGFIFQSYNLMPQLSALENVEMPLIFSGVCKIERIKRAKEMLERVGLKDRINHKPSELSGGQQQRVSIARALINNPKLILADEPTGNLDSKTSIEILDLLKGLNKKYNMTFVVVTHSHVVYEYANKIIKMEDGLLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLU1</accession>
    <name>A0A386PLU1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ORF">CP523_14200</name>
        <name evidence="11" type="ORF">EI377_09105</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678511.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00282"/>
    <dbReference type="EnsemblBacteria" id="AYE35489">
        <property type="protein sequence ID" value="AYE35489"/>
        <property type="gene ID" value="CP523_14200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60875">
        <property type="protein sequence ID" value="QAS60875"/>
        <property type="gene ID" value="EI377_09105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="32486" checksum="4FB2CB7AD13C6284" modified="2018-12-05" version="1">MLKIIEKSKIWFSISLIIILIGLGFIFTRGLNFGIDFKGGTKVVIELGENFNKSEVDEIVKKYADDAVTNEVDKTQYEIKSRDLDTSKVAELFKELKEKYNLEDKALLSQEEIGASIGKELTRNSIVALIIACGAMLIYIAFRFKMNYGIAALLALLHDVLITLSIFAIFNIPVNTPFIASILTIIGYSINDTIVIFDRIRENSKNMRRAPAIEIANKSLTQTLARSINTTLTTLFVIASVNVFVPTVREFSFPLLIGIAFGAYSSLFIASPIWVILKNREEKKKEMKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PME3</accession>
    <name>A0A386PME3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12885</name>
        <name evidence="2" type="ORF">EI377_07765</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35869">
        <property type="protein sequence ID" value="AYE35869"/>
        <property type="gene ID" value="CP523_12885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62179">
        <property type="protein sequence ID" value="QAS62179"/>
        <property type="gene ID" value="EI377_07765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="41" mass="4577" checksum="FE06142531155849" modified="2018-12-05" version="1">MDTSKNIVSTSYCATRLRLVLYICSNYTSYCCSGLTYGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMF5</accession>
    <name>A0A386PMF5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15075</name>
        <name evidence="4" type="ORF">EI377_10030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676150.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01269"/>
    <dbReference type="EnsemblBacteria" id="AYE35889">
        <property type="protein sequence ID" value="AYE35889"/>
        <property type="gene ID" value="CP523_15075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62200">
        <property type="protein sequence ID" value="QAS62200"/>
        <property type="gene ID" value="EI377_10030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="32219" checksum="7808AEE7120AD871" modified="2018-12-05" version="1">MRISECRKEINEYLSSYFNNKGSYNKIIYDSASYSLNVGGKRIRPILLLLTYGLYNGSYKDVIEMAAALEMIHTYSLIHDDLPCMDNDDLRRGMPTNHKKFGEDIAVLAGDTLLNEAMILMMNYSLNNGERALIAAKEIAEAAGAEGMIGGQVVDIINEGKEISKEELEYMHLKKTGELIRVSLVSGAILAEAPKKDIDILNEFGKKLGLAFQIKDDILDEVGDVKKLGKNTKSDKNNDKSNFLSIFGIDYCKNKCKSLTDECISLLDSLSVNAKIVKELTLELLNREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB63</accession>
    <name>A0A386PB63_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem reaction center subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01170</name>
        <name evidence="3" type="ORF">EI377_11670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674396.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02284"/>
    <dbReference type="EnsemblBacteria" id="AYE33163">
        <property type="protein sequence ID" value="AYE33163"/>
        <property type="gene ID" value="CP523_01170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61333">
        <property type="protein sequence ID" value="QAS61333"/>
        <property type="gene ID" value="EI377_11670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="162" mass="18603" checksum="6B853F504478AB17" modified="2018-12-05" version="1">MLKTKDFYLMKVYDIKGKYLGVIDDLCIDFYNAKVKGFFISNFLLLSNKNFIEIDDIISLDEVIIVKKIKHYKGLSFGDIKDMDIIDTENIMKGVLEDLIIEKADFSIKGLVMSSGIFDKMIKGKEILLVSECILGEDFILYHGSESIRLKSIPHKKYSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB87</accession>
    <name>A0A386PB87_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnfB</name>
        <name evidence="8" type="ORF">CP523_01285</name>
        <name evidence="9" type="ORF">EI377_11785</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675555.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00808"/>
    <dbReference type="EnsemblBacteria" id="AYE33185">
        <property type="protein sequence ID" value="AYE33185"/>
        <property type="gene ID" value="CP523_01285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61355">
        <property type="protein sequence ID" value="QAS61355"/>
        <property type="gene ID" value="EI377_11785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00463">
        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010207">
        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="27447" checksum="C25F1AD013922190" modified="2018-12-05" version="1">MNILFSALSLGILGLIFGILLGFASKAFEVKVDPKIPKIRECLPGANCGGCGYAGCDAYAEAVVNSGAKANLCSVGGAKVAEELGNILGVSVESTEKMTAFVKCNGNCSVAKENYDLEGVTDCLTASLMVDGGSKACSYGCLGLGSCVSVCEFGALEIVNGIAKVNSDKCTNCGACINICPKGLIESVPISKKVRVECNNKEIGKHVKENCSAACIGCKICERNCPKDAVHVVNNVAKVDYDKCVNCQICTKKCPTGAIKNIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC06</accession>
    <name>A0A386PC06_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02825</name>
        <name evidence="3" type="ORF">EI377_13350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676994.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00971"/>
    <dbReference type="EnsemblBacteria" id="AYE33473">
        <property type="protein sequence ID" value="AYE33473"/>
        <property type="gene ID" value="CP523_02825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61644">
        <property type="protein sequence ID" value="QAS61644"/>
        <property type="gene ID" value="EI377_13350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="19605" checksum="82AC78C14AC0798E" modified="2018-12-05" version="1">MKKVAVLLANGFETLEALTVVDILRRAEVGCDTFGVNGLEITTSHKIKIIADKVLDVNEVNKYDVLVLPGGMPGSINLRDDERVVSLIKEFNNNGKYVCAICAAPIALGKAEITTGKNITCYPGFEKELEGCNYKEDLVVIDNNIITGKGPAAAIEFAFEILSKINLEKVDEIKKGMLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC75</accession>
    <name>A0A386PC75_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">dnaK</name>
        <name evidence="13" type="ORF">CP523_02270</name>
        <name evidence="14" type="ORF">EI377_12790</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674015.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00513"/>
    <dbReference type="EnsemblBacteria" id="AYE33370">
        <property type="protein sequence ID" value="AYE33370"/>
        <property type="gene ID" value="CP523_02270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61540">
        <property type="protein sequence ID" value="QAS61540"/>
        <property type="gene ID" value="EI377_12790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="617" mass="66166" checksum="57AB2C67808E223A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCC3</accession>
    <name>A0A386PCC3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">CP523_00980</name>
        <name evidence="12" type="ORF">EI377_11475</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674519.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02323"/>
    <dbReference type="EnsemblBacteria" id="AYE33127">
        <property type="protein sequence ID" value="AYE33127"/>
        <property type="gene ID" value="CP523_00980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61297">
        <property type="protein sequence ID" value="QAS61297"/>
        <property type="gene ID" value="EI377_11475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="24262" checksum="1F8F824A2921C9D1" modified="2018-12-05" version="1">MHKKNRGVLIVISGPSGAGKGTICKELLKNNDNLYLSVSATTRNPREGEIDGVNYYFLTRENFLKRVEENDFLEYAEVYGNCYGTPKSNVEKMLEEGKDVILEIDIQGALKVKENFSEGVFIFVLPPSMEELKQRIIKRGSETEESLMRRFKSAYKEINYVSKYNYAVVNDTLEVAVSKVEGIIAAEKCRVDRIKDNTILDSKEGLIHEQLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCL4</accession>
    <name>A0A386PCL4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03080</name>
        <name evidence="3" type="ORF">EI377_13580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678417.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33520">
        <property type="protein sequence ID" value="AYE33520"/>
        <property type="gene ID" value="CP523_03080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61686">
        <property type="protein sequence ID" value="QAS61686"/>
        <property type="gene ID" value="EI377_13580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="21050" checksum="7491B0AC8E6FEA4B" modified="2018-12-05" version="1">MKDLNLIIGNKLKIIRNTRNLTLDEVSKITGVSKAMLGQIERGQSNPTVSTLWKIANGLKVSFSLFIEENQNDLQIIHQNEVTPIIEDNKKMSLYPIFPFDVNKGFEIFTIELNPGCNHISNPHNDGVEEYIIVTEGEIVIDIDSKSFELKKGDSIRFIANKSHTYKNIKENKAVFQNIINYSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCR4</accession>
    <name>A0A386PCR4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmB</name>
        <name evidence="5" type="ORF">CP523_00910</name>
        <name evidence="6" type="ORF">EI377_11405</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008678335.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02337"/>
    <dbReference type="EnsemblBacteria" id="AYE33114">
        <property type="protein sequence ID" value="AYE33114"/>
        <property type="gene ID" value="CP523_00910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61284">
        <property type="protein sequence ID" value="QAS61284"/>
        <property type="gene ID" value="EI377_11405"/>
    </dbReference>
    <dbReference type="GeneID" id="66301534"/>
    <dbReference type="KEGG" id="csep:CP523_00910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="63" mass="7090" checksum="49BC48F99521F4C1" modified="2018-12-05" version="1">MARRCEVCNKGVVSGTQYSHSHRQSKRTWAPNIKRVKALVNGTPKTVHVCTRCLRSGKVQRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCT4</accession>
    <name>A0A386PCT4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">CP523_01015</name>
        <name evidence="17" type="ORF">EI377_11510</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674503.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02316"/>
    <dbReference type="EnsemblBacteria" id="AYE33134">
        <property type="protein sequence ID" value="AYE33134"/>
        <property type="gene ID" value="CP523_01015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61304">
        <property type="protein sequence ID" value="QAS61304"/>
        <property type="gene ID" value="EI377_11510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01015"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="178"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="332" mass="36198" checksum="1E57C1CDCA5A2D64" modified="2018-12-05" version="1">MRNVTFLGGGSFGTSLAILLADKGNKIKIYDRDEHVVNDINYNRRNDKYIKNLKIPKNVTAYNDIDLALNEAEFIVLAIPSHVIRSISKELKGKIKENVTIISIAKGIEQGTNLRLSEVIKEELPSNPVVILSGPSHAEEVALNIPTTVVVSSTDMEKAAEVQDIFINSNFRVYTNDDLVGVEIGGAVKNIIALAAGVCDGIGYGDNSKAALMTRGMAEIVRIGMKLGGKPETFLGLTGMGDLIVTCTSLHSRNRRAGYLIGTGKTSNEAIEEVGMIVEGIKACKAFYELKEKLGIEMPITDVAYKVLFKGKDPKEAVKELMGRSKKDEIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDA7</accession>
    <name>A0A386PDA7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05565</name>
        <name evidence="2" type="ORF">EI377_00210</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33975">
        <property type="protein sequence ID" value="AYE33975"/>
        <property type="gene ID" value="CP523_05565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59372">
        <property type="protein sequence ID" value="QAS59372"/>
        <property type="gene ID" value="EI377_00210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032871">
        <property type="entry name" value="AHH_dom_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14412">
        <property type="entry name" value="AHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="29434" checksum="DE7002EA0B948EDD" modified="2018-12-05" version="1">MGYLPEIANKIKNGERVEKIVDSIRGAKGAAEAVSKIRTVSSDFLNYVKDSIIDLGDRIAYKPALAGASDDAFYYMSKSEISDINKLESTARSAGRLEESACEIAKDTSRVISMTERIAEYDKVMHNTTLKVSHTASESHADILRKELYAEGITPPPYGNACHHIVAWDAEKASVSRGILSKYGIDVDSASNGVLLPYEKNAYVTTEAMHNGGHSAEYYLQVENRLKEADKFIVSKNLSVNDAKMIMSETLNNIRKDLLNGILKVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDC6</accession>
    <name>A0A386PDC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01742"/>
    <dbReference type="EnsemblBacteria" id="AYE33800">
        <property type="protein sequence ID" value="AYE33800"/>
        <property type="gene ID" value="CP523_04595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="112" mass="12817" checksum="006DCE67D11C9AD1" modified="2018-12-05" version="1">MQNRMEAVLRKYMPNNISIINFAAYTAKVIIKDGNLAYETDIEGMWDMERYITLLMGEIPRLSEDIYGYGPKEKGFIAHVDIPNEVVEAFSELKEEYSELIGEANPLYASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDM0</accession>
    <name>A0A386PDM0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Iron ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03330</name>
        <name evidence="4" type="ORF">EI377_13845</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677214.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02118"/>
    <dbReference type="EnsemblBacteria" id="AYE33567">
        <property type="protein sequence ID" value="AYE33567"/>
        <property type="gene ID" value="CP523_03330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61730">
        <property type="protein sequence ID" value="QAS61730"/>
        <property type="gene ID" value="EI377_13845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362743" evidence="2">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="37357" checksum="40B8FE42C19C6345" modified="2018-12-05" version="1">MKRKRLLALSVATLLTAGLFTACGSKETSKNDMKLTIYCGLMEDHMVKIVEEFKNETGIQAEAVRMSSGEVLGRLRAEKDNPKASVWYGGPADAFVQAKEDGLLEKYVSDNAKDIPDKYKDKDGSWTGIYVGYLGFASNKKLLEEKGVKAPESWEDLLKPEFKGQISIANPGSSGTAYTALATMVQLKGEEKGLEYMKELNKNVKSYEKSGTAPARLAGQGEVMIGVSYLHDGIKYREEGMKDIVLTSPKEGTGYEIGATAIVKNGPDQETAKMFIDFVLSKKGQEVGQTVGSYQFLTNETAKAPAIADEIKDTKLIDYDLEWAGKVRSELVEKWNNAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE62</accession>
    <name>A0A386PE62_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04300</name>
        <name evidence="2" type="ORF">EI377_14830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676479.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33747">
        <property type="protein sequence ID" value="AYE33747"/>
        <property type="gene ID" value="CP523_04300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61903">
        <property type="protein sequence ID" value="QAS61903"/>
        <property type="gene ID" value="EI377_14830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="152" mass="17468" checksum="9BBCFFF6BAA5A6C0" modified="2018-12-05" version="1">MKLAEALILRSDLQKKVASLRSRIIRNAKVQEGEKPGESPNELIVELNSTIKELEELVNKINRTNSRTVVEGSIVISDLISKREFLGKQNQILRELTDAATIKFDRYSKSEVKFYSTVNVSEIQKEIDRISKEYRLTDTKLQGLNWTVDLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE65</accession>
    <name>A0A386PE65_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06250</name>
        <name evidence="4" type="ORF">EI377_00725</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00020"/>
    <dbReference type="EnsemblBacteria" id="AYE34100">
        <property type="protein sequence ID" value="AYE34100"/>
        <property type="gene ID" value="CP523_06250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59467">
        <property type="protein sequence ID" value="QAS59467"/>
        <property type="gene ID" value="EI377_00725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="37"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="27172" checksum="5F9025AA087A48EE" modified="2018-12-05" version="1">MHLILILIIIIISYSILPTMILKIYWYIKSYKMGKEKVVFLTFDDGPSSEYTPELLDLLKEFNIKASFFVVTDFAKENINLIKRMKLEGHDIGVHSCSHENSIYRGWKYTSRDLSESVKVMEEMNVRILGYRPPWGHLNIFTLYMIKKLKLKLILWGAMAQDWKANTTVEEISRKIINKIDKGNLILCLHDGRGEKKAPERTIEALRKTIPILIKKGYKFKSLGEYYESIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE70</accession>
    <name>A0A386PE70_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02070</name>
        <name evidence="9" type="ORF">EI377_12590</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33331">
        <property type="protein sequence ID" value="AYE33331"/>
        <property type="gene ID" value="CP523_02070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61501">
        <property type="protein sequence ID" value="QAS61501"/>
        <property type="gene ID" value="EI377_12590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="10350" checksum="AD040FCBEE0A2ADA" modified="2018-12-05" version="1">MIRYYITVEGRVQGVGFRFFCQSHANLMNLTGFVHNMNNGMVELQIQGSKEVIDEFISIVKKGNFFIKVKDMYTKKIPLIEKEKGFKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE88</accession>
    <name>A0A386PE88_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_03310</name>
        <name evidence="12" type="ORF">EI377_13825</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677221.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02122"/>
    <dbReference type="EnsemblBacteria" id="AYE33564">
        <property type="protein sequence ID" value="AYE33564"/>
        <property type="gene ID" value="CP523_03310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61727">
        <property type="protein sequence ID" value="QAS61727"/>
        <property type="gene ID" value="EI377_13825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="321"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="580" mass="67470" checksum="22D0D8A7F077A44C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA3</accession>
    <name>A0A386PEA3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_07965</name>
        <name evidence="10" type="ORF">EI377_02725</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675911.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00708"/>
    <dbReference type="EnsemblBacteria" id="AYE34363">
        <property type="protein sequence ID" value="AYE34363"/>
        <property type="gene ID" value="CP523_07965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59769">
        <property type="protein sequence ID" value="QAS59769"/>
        <property type="gene ID" value="EI377_02725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="574" mass="63636" checksum="14E83D36F93535C1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC2</accession>
    <name>A0A386PEC2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">CP523_08065</name>
        <name evidence="5" type="ORF">EI377_02825</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675946.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00728"/>
    <dbReference type="EnsemblBacteria" id="AYE34383">
        <property type="protein sequence ID" value="AYE34383"/>
        <property type="gene ID" value="CP523_08065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59789">
        <property type="protein sequence ID" value="QAS59789"/>
        <property type="gene ID" value="EI377_02825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08065"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="38843" checksum="BA590BC3CA14B122" modified="2018-12-05" version="1">MKAKLILENGMIFEGKAFGYLKDSVGEVVFTTGMTGYQEVLTDPSYYGQIVTMTYPLIGNYGINLEDMESDSLKVKGFIVREKCSFPNNFRCEMGLEDFLKQNKIIGLEGIDTRALTKVLRNYGTMKGIISLESHSIEEVEERIKAFSNKEAVSIVSTKNAYTIEGQGKHVAIMDFGIKQNIIRNFKNRGCKITVFPMTTTAEEILEVNPDLVFLSNGPGDPEDLTDVIENIKKIVGKKPIVGICLGHQLLGLTLGGKTTKLKFGHRGCNHPVKDLEENKVHITSQNHGYVVEILPKDVVATHININDGTIEGMKHTKLPIFSVQFHPEAAAGPKDSEYIFDKFMNYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEE8</accession>
    <name>A0A386PEE8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00510</name>
        <name evidence="3" type="ORF">EI377_11000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676317.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00631"/>
    <dbReference type="EnsemblBacteria" id="AYE33036">
        <property type="protein sequence ID" value="AYE33036"/>
        <property type="gene ID" value="CP523_00510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61205">
        <property type="protein sequence ID" value="QAS61205"/>
        <property type="gene ID" value="EI377_11000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="100" mass="11052" checksum="8432501B4A2B4420" modified="2018-12-05" version="1">MKKNIKILKWIAGGIEAFLSIPILGASIILSLLWIPLAIMLALHITILVFCKKEDLPITGNILGIIASALGWVPFVGWIMHILTAIFVMIEASKIKFIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH0</accession>
    <name>A0A386PEH0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fliG</name>
        <name evidence="13" type="ORF">CP523_02610</name>
        <name evidence="14" type="ORF">EI377_13145</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673910.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00445"/>
    <dbReference type="EnsemblBacteria" id="AYE33431">
        <property type="protein sequence ID" value="AYE33431"/>
        <property type="gene ID" value="CP523_02610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61605">
        <property type="protein sequence ID" value="QAS61605"/>
        <property type="gene ID" value="EI377_13145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="120"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="221"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="338" mass="37976" checksum="7C08EBADCFBFF1C0" modified="2018-12-05" version="1">MAREKNKLSGLQKAAILFITLGPEVSSPIFKKLPDHEIQKITYEIANISTVSVEERQEILDEFLEMNRARDYIIEGGIEYARTLLSKALGPQRASDILSKVTEATQQYRPFSIARKADAHQLLNVISYEHPQTIALILCYLQLDKAAQVMAELPEDTQSEVAYRIATMSDTSPMVIREIEKVLENKLSMVVRSEMTSLGGVDTLVGILNQVDRTTEKNITESLEREDADLADRVKSSMFVFEDIITLDDVSIQRVLREVDIKDLSLALKGCSDEVSNAIYRNQSKRAAASLKEDMEYLGPVRLMDVEKAQQKVVSIIRRLDDAQEIVISRGGEDAIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM6</accession>
    <name>A0A386PEM6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02688"/>
    <dbReference type="EnsemblBacteria" id="AYE34495">
        <property type="protein sequence ID" value="AYE34495"/>
        <property type="gene ID" value="CP523_08735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="167" mass="19063" checksum="9E2C50EAACE94402" modified="2018-12-05" version="1">MMHREVIARKKVSVISISVVLITVVLYISQAIKIAGLDNHKVGYLIKSLLVVFTVVILLKELKSCGLAYKHSIIAGKLIINKISLKEEKNLESIKIQDILYIGKKCEIPKEYSSIRSYKKYLCNRIGNDIYCCVYKSGNKIKKFNFQPSRSFIERIIKHGALSCKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN0</accession>
    <name>A0A386PEN0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA epoxyqueuosine(34) reductase QueG</fullName>
            <ecNumber evidence="10">1.17.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">queG</name>
        <name evidence="9" type="ORF">CP523_04065</name>
        <name evidence="10" type="ORF">EI377_14585</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 12">VAT12</strain>
        </source>
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        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
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    <dbReference type="STRING" id="1504.GCA_900092375_02773"/>
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        <property type="protein sequence ID" value="AYE33704"/>
        <property type="gene ID" value="CP523_04065"/>
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        <property type="gene ID" value="EI377_14585"/>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
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        <property type="entry name" value="QueG_DUF1730"/>
    </dbReference>
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        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08331">
        <property type="entry name" value="DUF1730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00276">
        <property type="entry name" value="TIGR00276"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="330" mass="38571" checksum="81F2A39C774E8A1C" modified="2018-12-05" version="1">MGIKEDILEYCSSLGLDTVGFIKCRKFEELKDFYEDRKLKGLENEFEEESIENRINPNIYMKEGKTIISIAFPYLHNIDYIENGFSMYTRGLDYHKVVKEYLEKISNYINSLGGNAITFVDSNTLPERYIAYLSGIGFIGKNNMIITKKYGSYVFLGEIITDLEIQCEDIRTFSEISSFKECGNCEICYSECPTKAINRIRKNSNICVSYLTQKKDLEDKFIKLLDGRVFGCDSCQKKCPYNLEVEYSTIKDFYPLNFMNEENSDFLINMGNKEFKETFQITSCGWRGKNVLKRNAIIRKKYNGENIDGFKTDSPYLKDYIHRLFFRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU4</accession>
    <name>A0A386PEU4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VWA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04385</name>
        <name evidence="4" type="ORF">EI377_14925</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00401"/>
    <dbReference type="EnsemblBacteria" id="AYE33764">
        <property type="protein sequence ID" value="AYE33764"/>
        <property type="gene ID" value="CP523_04385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61921">
        <property type="protein sequence ID" value="QAS61921"/>
        <property type="gene ID" value="EI377_14925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
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        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362736" evidence="1">
        <location>
            <begin position="25"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="71"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="574" mass="63568" checksum="9EF5E2682544FCC6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX1</accession>
    <name>A0A386PEX1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03420</name>
        <name evidence="3" type="ORF">EI377_13945</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02235"/>
    <dbReference type="EnsemblBacteria" id="AYE33581">
        <property type="protein sequence ID" value="AYE33581"/>
        <property type="gene ID" value="CP523_03420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61745">
        <property type="protein sequence ID" value="QAS61745"/>
        <property type="gene ID" value="EI377_13945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03420"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
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    </dbReference>
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        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="105" mass="12164" checksum="C8A85016354D1D95" modified="2018-12-05" version="1">MQFTKSISNIQAENLIKEDKELLILDVRRFTEFKENRIPNAINIPVDDLEWEMETLENHKDNPILVYCKVGMRSSVACDILENEGFTKLYNLRGGILDYTGAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF43</accession>
    <name>A0A386PF43_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09625</name>
        <name evidence="4" type="ORF">EI377_04400</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676698.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02631"/>
    <dbReference type="EnsemblBacteria" id="AYE34663">
        <property type="protein sequence ID" value="AYE34663"/>
        <property type="gene ID" value="CP523_09625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60063">
        <property type="protein sequence ID" value="QAS60063"/>
        <property type="gene ID" value="EI377_04400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="237" mass="27215" checksum="592A36F50E3A21F1" modified="2018-12-05" version="1">MGCFMEKIKIFLHKNKYKIIGSILLIILLICFYEYYAKYSMLFRNPENIKKLILSYGKYSFIAYIALQFLQIVVFFIPGELVQIAGGYIFGAWEGFLLSFIGILIGSVFSFLLARLLGKSYVEKIVFKEDKWLFKKIEEIKRDKKKFKELVFIMYLIPGIPKDILGYICGVTTLTLKEFTIISMLGRAPALFISCFFGNKMSVDNIGMLILIAIIVGVIFIVSIIKGKKFISNYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF55</accession>
    <name>A0A386PF55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04980</name>
        <name evidence="4" type="ORF">EI377_15480</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33874">
        <property type="protein sequence ID" value="AYE33874"/>
        <property type="gene ID" value="CP523_04980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62016">
        <property type="protein sequence ID" value="QAS62016"/>
        <property type="gene ID" value="EI377_15480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362707" evidence="1">
        <location>
            <begin position="26"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="339"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="641" mass="71682" checksum="C34C97245E925091" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG7</accession>
    <name>A0A386PFG7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VanZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06740</name>
        <name evidence="4" type="ORF">EI377_01215</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679144.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01568"/>
    <dbReference type="EnsemblBacteria" id="AYE34187">
        <property type="protein sequence ID" value="AYE34187"/>
        <property type="gene ID" value="CP523_06740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59551">
        <property type="protein sequence ID" value="QAS59551"/>
        <property type="gene ID" value="EI377_01215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="148" mass="17408" checksum="DA0FA87592BA9222" modified="2018-12-05" version="1">MKNNRKVISWIMLIIWMCIIFFMSNQPGDVSSRQSELVLKIFAFIGINLNEYLGELATFIVRKTAHFSEYLILFMLEYNVLRFYMDRSKARMYSVLGVFLYACSDEIHQYFIPGRAMAFKDVLIDTSGGIVGFVIRYIHDNKYNIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI9</accession>
    <name>A0A386PFI9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">bioA</name>
        <name evidence="6" type="ORF">CP523_06930</name>
        <name evidence="7" type="ORF">EI377_01415</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01000"/>
    <dbReference type="EnsemblBacteria" id="AYE34207">
        <property type="protein sequence ID" value="AYE34207"/>
        <property type="gene ID" value="CP523_06930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59572">
        <property type="protein sequence ID" value="QAS59572"/>
        <property type="gene ID" value="EI377_01415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06930"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="316"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="448" mass="51409" checksum="741A852E3A44D8D2" modified="2018-12-05" version="1">MNLIDKDFKYIWHPCSQMKDYEELKIIVIERGEGIYLYDTYGNRYLDAISSWWCNLFGHANKRINNAIINQINKIEHVIFANFSNIPAIELSERLVKITPERLEKVFFADNGSAAVEIALKMSFHYHQQIGKTKKQKFVAITDAYHGETLGALSVGDIDIYNKVYRPLMVDTYRVQGPDCYRCNYEKNRDSCNAECFKYMEELLANNHHEISAVIIEPMVQGAAGMKIYSPKYLKSLRALCDKYDINLIADEIAVGYGRTGKMFACEHAEISPDIMCLSKGLTAGYMPMSVVMTSNKLYNVFYGDYSEYKAFLHSHTYSGNAMGCAVALEVLKIFEEENILNMINKKGKMLNEILLSELNSHQLIGEIRNIGLINAIELVSNKETKESFPSEKRVGYEIYKIALKKGVVLRPIGNCLYFNPPYIIEEEEMKEMVRVCKESLDEYILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN4</accession>
    <name>A0A386PFN4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10910</name>
        <name evidence="2" type="ORF">EI377_05705</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02516"/>
    <dbReference type="EnsemblBacteria" id="AYE34875">
        <property type="protein sequence ID" value="AYE34875"/>
        <property type="gene ID" value="CP523_10910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60270">
        <property type="protein sequence ID" value="QAS60270"/>
        <property type="gene ID" value="EI377_05705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="337" mass="38999" checksum="161E1CCDE5223766" modified="2018-12-05" version="1">MIILHAAGNEKIGLGNLTRVKALVKYLCSIKYNNFKVILEAREDIAKMFIVDDVDYFIAENRKIAQKFLEDNMFNKSSEKLVLISDLVDMNYSDNEFYRRCGFDVLIQINDENVNKFNPDIYINSDIFYQEFNVNSQTKIYSGSKFLVVRDEILKQRPLECWNKDKIENILVCFGGSDPARYTEDIVKLIRNNMVYDNYNFNVVLGPGVSDERKRELIKNANNNIKFLVNEKHMERKIIENDLIITLGGLTTYEALALGRPVCCIGWEYMNYYVDNLSKNNWIYKLGNKSKDLEGLEKCLLDIDRLKAIASKGFKNINHRGAENMVNIAIKAEKGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP4</accession>
    <name>A0A386PFP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10960</name>
        <name evidence="3" type="ORF">EI377_05755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677658.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02526"/>
    <dbReference type="EnsemblBacteria" id="AYE34885">
        <property type="protein sequence ID" value="AYE34885"/>
        <property type="gene ID" value="CP523_10960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60280">
        <property type="protein sequence ID" value="QAS60280"/>
        <property type="gene ID" value="EI377_05755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="352" mass="40462" checksum="E8BA03E50848D4A5" modified="2018-12-05" version="1">MLCAVIMAGGRGTRFWPLSTDNKPKQFLSLIDEETMIQKTINRILPIIPLERIFVCTGKKYVNLVKEQLPNLPERNIIVEPEGKNTAPCIALSALTIKRYYGDSTMVVLPSDHLIREENKFREILIKADNFLKKHNKGLMTLGMHPDRPETGYGYINCGKEIDDDINKVEAFVEKPNKEKAEEYLKLGGYLWNGGMFLWKVNTILDEIKKYIPNTYEALQAMQNIDEEDIERFVNQQYQKVDEISIDYAVLEKSDDIYVIKSDIGWDDIGTWRAIERYREKDGYNNIYFNNTVSIDSSNNMVIGNHNNNVVMIGVSNVATIVSDEGIYVINRELLDDVKDFKEGIKNNNNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS6</accession>
    <name>A0A386PFS6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11110</name>
        <name evidence="2" type="ORF">EI377_05900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677074.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00918"/>
    <dbReference type="EnsemblBacteria" id="AYE34915">
        <property type="protein sequence ID" value="AYE34915"/>
        <property type="gene ID" value="CP523_11110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60309">
        <property type="protein sequence ID" value="QAS60309"/>
        <property type="gene ID" value="EI377_05900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="9650" checksum="410722FF0967EA72" modified="2018-12-05" version="1">MSQRKKAVALKYEENFIAPSVTASGMGIIADNIIEKAEENDVPIVYNKELTDLLCNVDVGSDIPPELYEAVAHIIAYVTDLDRIVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT3</accession>
    <name>A0A386PFT3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02405</name>
        <name evidence="2" type="ORF">EI377_12925</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673972.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00486"/>
    <dbReference type="EnsemblBacteria" id="AYE33392">
        <property type="protein sequence ID" value="AYE33392"/>
        <property type="gene ID" value="CP523_02405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61564">
        <property type="protein sequence ID" value="QAS61564"/>
        <property type="gene ID" value="EI377_12925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="15892" checksum="904C466C8A5B325D" modified="2018-12-05" version="1">MYIAFGRRVVDSEEVRNTIVDNSEFRIVKDMSKGSKREDIVAFNLSIDIGILREVLEDDYDLNQLSEDELFEEYLSLAEELATDIEEFCPDESLIDIKAYKLDESDNDIKLVMVIAHEELGEPKLRDVMKRLLTQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW9</accession>
    <name>A0A386PFW9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-type HAD-IIB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05125</name>
        <name evidence="2" type="ORF">EI377_15685</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676212.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01815"/>
    <dbReference type="EnsemblBacteria" id="AYE33901">
        <property type="protein sequence ID" value="AYE33901"/>
        <property type="gene ID" value="CP523_05125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62052">
        <property type="protein sequence ID" value="QAS62052"/>
        <property type="gene ID" value="EI377_15685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="277" mass="30695" checksum="1708BCDD06D6AC4B" modified="2018-12-05" version="1">MSNYKLICIDMDGTLLDDNHKVSNENKLALKAATEKGVKVAITTGRIFCSAKYYSDLIGVDAPVIASNGAYVREKNSDKPIFENPLPAKILHEVYSIIRKYGLHVNLNTSDTVLRETEVPKDHAYAIMNKNLPDDQKIKFIISEDLTKYIDDFNGQILKAITIEEENIDALFKAKEELKEKFKDELHIVSSSPKNFEVMLGTSSKGNAVKKLAENFGLSPENVICIGDSENDLSMLRYAGLGVAMGNGLDIVKEEADFITDTNLNSGVAKVIEKFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG07</accession>
    <name>A0A386PG07_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">feoB</name>
        <name evidence="12" type="ORF">CP523_08035</name>
        <name evidence="13" type="ORF">EI377_02795</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00722"/>
    <dbReference type="EnsemblBacteria" id="AYE34377">
        <property type="protein sequence ID" value="AYE34377"/>
        <property type="gene ID" value="CP523_08035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59783">
        <property type="protein sequence ID" value="QAS59783"/>
        <property type="gene ID" value="EI377_02795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="394"/>
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            <begin position="463"/>
            <end position="482"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="508"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="570"/>
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            <end position="619"/>
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            <end position="662"/>
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            <begin position="682"/>
            <end position="706"/>
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            <end position="187"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="707" mass="78318" checksum="2A251EF51D93B91B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA0</accession>
    <name>A0A386PGA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic lactone autoinducer peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12090</name>
        <name evidence="3" type="ORF">EI377_06920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02975"/>
    <dbReference type="EnsemblBacteria" id="AYE35095">
        <property type="protein sequence ID" value="AYE35095"/>
        <property type="gene ID" value="CP523_12090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60488">
        <property type="protein sequence ID" value="QAS60488"/>
        <property type="gene ID" value="EI377_06920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12090"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009229">
        <property type="entry name" value="AgrD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04223">
        <property type="entry name" value="quorum_AgrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362947" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="44" mass="4951" checksum="A879F6124D44FB0E" modified="2018-12-05" version="1">MRKLNKKVLVGVATFATVFASVIATSACFWCTYQPKEPKCLRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC4</accession>
    <name>A0A386PGC4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">feoB</name>
        <name evidence="12" type="ORF">CP523_01510</name>
        <name evidence="13" type="ORF">EI377_12030</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00854"/>
    <dbReference type="EnsemblBacteria" id="AYE33229">
        <property type="protein sequence ID" value="AYE33229"/>
        <property type="gene ID" value="CP523_01510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61401">
        <property type="protein sequence ID" value="QAS61401"/>
        <property type="gene ID" value="EI377_12030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="11">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="669" mass="73720" checksum="F8FFD0721632B608" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI6</accession>
    <name>A0A386PGI6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal protein PDZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06470</name>
        <name evidence="4" type="ORF">EI377_00950</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
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</entry>
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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    <sequence length="581" mass="67139" checksum="9DBCC3BFEF6BC7CA" modified="2018-12-05" version="1"> </sequence>
</entry>
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="protein sequence ID" value="QAS59997.1"/>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
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        <property type="protein sequence ID" value="AYE34597"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="329" mass="38142" checksum="7011F8768BE561B6" modified="2018-12-05" version="1">MNDKLKSLIQENRIFIIALISTAFFTTLIVIFIFQYTGLSKTMKEFNNIAKEINKINLSLEDCVDDLTIDTKKSIETLNNSSKKLKELSSKISEVEIKSDIDSKIKSNLSDSLATTITLYDFCFHIISDSSNIKSGDEINEFNTYKENCLNSYNSLAENNIYIRFSEKSLLFFDNANNYVNTIIKVNRDNDIKNIQKREFVLILDSFTSTIDKLCQDLTPAIQKVKEDKRDLKVILDDISEKEKLLEDLKNNVHSMSIPDGCMEFYNSLQEFLKIYDVYIKSMKEAVTFEKGCSDLNKYSKEIDRNYENAKSKFQDVLNSYDKYKNMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR8</accession>
    <name>A0A386PGR8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="8" type="ORF">CP523_02320</name>
        <name evidence="9" type="ORF">EI377_12840</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673998.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00503"/>
    <dbReference type="EnsemblBacteria" id="AYE33379">
        <property type="protein sequence ID" value="AYE33379"/>
        <property type="gene ID" value="CP523_02320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61549">
        <property type="protein sequence ID" value="QAS61549"/>
        <property type="gene ID" value="EI377_12840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="9397" checksum="0CB4EDAB11CF478A" modified="2018-12-05" version="1">MANIKSAKKRIKVTEAKTAQNRMIKSALKTAIKKFEAAVSANNADEANVLFPKAVKALDMAAQKGVCHKNMVARKKSRLAAKLNAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS4</accession>
    <name>A0A386PGS4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3784 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04325</name>
        <name evidence="3" type="ORF">EI377_14860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33752">
        <property type="protein sequence ID" value="AYE33752"/>
        <property type="gene ID" value="CP523_04325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61909">
        <property type="protein sequence ID" value="QAS61909"/>
        <property type="gene ID" value="EI377_14860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="107" mass="12185" checksum="9580D647340B8AA2" modified="2018-12-05" version="1">MMGTNLAVIFIFSLLAGTLFLVLGGIIKHFNAGDMINFFNEKKHDKDKFSRIVGNNFLIIGFSIMLISIISIFVDKSYYIYILNMQATVILFGIIITIYQVFKYGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ5</accession>
    <name>A0A386PGZ5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">glmU</name>
        <name evidence="17" type="ORF">CP523_08495</name>
        <name evidence="18" type="ORF">EI377_03245</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674845.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01640"/>
    <dbReference type="EnsemblBacteria" id="AYE34464">
        <property type="protein sequence ID" value="AYE34464"/>
        <property type="gene ID" value="CP523_08495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59867">
        <property type="protein sequence ID" value="QAS59867"/>
        <property type="gene ID" value="EI377_03245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08495"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
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        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="16">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="8"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="250"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
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        <location>
            <position position="349"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
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        <location>
            <position position="364"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
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        </ligand>
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        <location>
            <position position="375"/>
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        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
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        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE34464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS59867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="456" mass="50079" checksum="007D3C89FF20EC3B" modified="2018-12-05" version="1">MYKCAVILAAGQGTRIKSDLPKVLHKVAGKEMVNHVIDTMRKAEIQDVNVIIGKGAELVRKNTESRNISYSIQAEQLGTGHAVKCAIDFLKDKKGTVGIFCGDAPLIKSETVKRLFEEHEKNKNSATLLTSIIEDPTGYGRVIRENNEVLKIVEHKDCNEEELKVKEMNAALYCFDIEELLESLDKLSNNNNQGEYYLTDVIGILKEKGSKVGAVVIDYEETIGVNSRVQLAEAENILRDRINLRHMTNGVTLIDPSSTYIGDDVIIGKDTIIYPGNVVEGKSIIGERVMLYPNSRIKDSEIGNEVEIQSSVILNSKIGENTTVGPFAYIRPESVIGKSARIGDFVEIKKSSIGDNTKVSHLTYIGDAEVGSDCNFGCGTVVVNYDGKEKHKTIIGDNSFIGCNTNLISPIRVGDNTYIAAGSTITNEVKKGELAVARAKQRNIEGWVKKRGLTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH19</accession>
    <name>A0A386PH19_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsH</name>
        <name evidence="10" type="ORF">CP523_08630</name>
        <name evidence="11" type="ORF">EI377_03380</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674900.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01667"/>
    <dbReference type="EnsemblBacteria" id="AYE34484">
        <property type="protein sequence ID" value="AYE34484"/>
        <property type="gene ID" value="CP523_08630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59886">
        <property type="protein sequence ID" value="QAS59886"/>
        <property type="gene ID" value="EI377_03380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="190"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="600" mass="66041" checksum="D08F1A7BD6E17520" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH24</accession>
    <name>A0A386PH24_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RusA family crossover junction endodeoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09940</name>
        <name evidence="2" type="ORF">EI377_04725</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00317"/>
    <dbReference type="EnsemblBacteria" id="AYE34697">
        <property type="protein sequence ID" value="AYE34697"/>
        <property type="gene ID" value="CP523_09940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60098">
        <property type="protein sequence ID" value="QAS60098"/>
        <property type="gene ID" value="EI377_04725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036614">
        <property type="entry name" value="RusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05866">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103084">
        <property type="entry name" value="SSF103084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="23879" checksum="8FFC463BA6C2B91A" modified="2018-12-05" version="1">MNSYAKIIVPGSPISKSNFKLHNKSGRAILPYNTGKNHDRYALYEEEIAYYASIQNPGVVLEESLIAVLKVYYKSEKRHPDTANITKSIFDGIEKSGLIVNDAQIRRIITEEFYDKENPRFELEFFGESEFEVSYSIIPKNKKTDRILYSPIRKSVQISKSALSNTETTSNSSKYKCDICNREIKDDNYVKANSGKTLICRKCFNKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH63</accession>
    <name>A0A386PH63_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hyaluronoglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01816"/>
    <dbReference type="EnsemblBacteria" id="AYE33902">
        <property type="protein sequence ID" value="AYE33902"/>
        <property type="gene ID" value="CP523_05130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017196783" evidence="6">
        <location>
            <begin position="31"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1862"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="796"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1826"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1731"/>
            <end position="1758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1830"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1887" mass="209912" checksum="55D2A20CEEA66057" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH81</accession>
    <name>A0A386PH81_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable transcriptional regulatory protein CP523_14025</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14025</name>
        <name evidence="6" type="ORF">EI377_08930</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678645.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00222"/>
    <dbReference type="EnsemblBacteria" id="AYE35455">
        <property type="protein sequence ID" value="AYE35455"/>
        <property type="gene ID" value="CP523_14025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60843">
        <property type="protein sequence ID" value="QAS60843"/>
        <property type="gene ID" value="EI377_08930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
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        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
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        <property type="entry name" value="YebC-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="243" mass="26686" checksum="614829F6B3ACFBAD" modified="2018-12-05" version="1">MSGHSKWHNIQNKKGKADAKRGKIFTKIGKELVIAVKNGGPIPDNNPKLRDVIAKAKAANMPNDTIQRSIKKASGELASVNYEKIVYEGYGPSGVAVIVETLTDNKNRSAGNVRSAFTKGGGNMGAAGCVGFMFQEKGEIVIEREDQDEDELMMMALDAGAEDFAAEDEVFIITTSPEDFSSVREALESEGIEFLEAEVKMIPDTYTEIGEDDAKKFQKMLNLLDDDDDVQEVWHNAESEFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD7</accession>
    <name>A0A386PHD7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1858 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07505</name>
        <name evidence="3" type="ORF">EI377_02195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673800.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34298">
        <property type="protein sequence ID" value="AYE34298"/>
        <property type="gene ID" value="CP523_07505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59692">
        <property type="protein sequence ID" value="QAS59692"/>
        <property type="gene ID" value="EI377_02195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="6353" checksum="CA589ACDAE78BC3C" modified="2018-12-05" version="1">MITKEMTIGELIREKADAAEILMSFGMGCVGCPSAQAESLEEAAMVHGLSLEALLEALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE8</accession>
    <name>A0A386PHE8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_14270</name>
        <name evidence="13" type="ORF">EI377_09180</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02443"/>
    <dbReference type="EnsemblBacteria" id="AYE35503">
        <property type="protein sequence ID" value="AYE35503"/>
        <property type="gene ID" value="CP523_14270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60889">
        <property type="protein sequence ID" value="QAS60889"/>
        <property type="gene ID" value="EI377_09180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="PTHR13246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="689"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1214" mass="136569" checksum="8F7BD826C79C9917" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI1</accession>
    <name>A0A386PHI1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine nucleoside phosphorylase DeoD-type</fullName>
            <shortName evidence="4">PNP</shortName>
            <ecNumber evidence="4">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">deoD</name>
        <name evidence="6" type="ORF">CP523_14435</name>
        <name evidence="7" type="ORF">EI377_09410</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676820.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02480"/>
    <dbReference type="EnsemblBacteria" id="AYE35533">
        <property type="protein sequence ID" value="AYE35533"/>
        <property type="gene ID" value="CP523_14435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60920">
        <property type="protein sequence ID" value="QAS60920"/>
        <property type="gene ID" value="EI377_09410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="4">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="4">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="235" mass="25967" checksum="837DE3F057FA6287" modified="2018-12-05" version="1">MAKHLHIMAKEGDIAETVLLPGDPLRAKFIAETYLENPVCYNNVRGMYGYTGTYNGKRVSVQGTGMGLPSHSIYVNELIRFYGAKRLIRIGSAGSINENVNVRDIVLAQSVSTNSGINKRRFKGMDYAPTANFELLLEAYNKGIEKGVNIKVGNVLSSDLFYDDTDVGINLWADYGCLAVEMESAELYTVAAKYGVEALSILTISDHIFKGIETTPEERQESFTDMMEIALELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHL7</accession>
    <name>A0A386PHL7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14670</name>
        <name evidence="3" type="ORF">EI377_09635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678856.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00140"/>
    <dbReference type="EnsemblBacteria" id="AYE35573">
        <property type="protein sequence ID" value="AYE35573"/>
        <property type="gene ID" value="CP523_14670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60959">
        <property type="protein sequence ID" value="QAS60959"/>
        <property type="gene ID" value="EI377_09635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="365" mass="42331" checksum="A2E0F398661C8A78" modified="2018-12-05" version="1">MLDYNSVFKEKLGKMLFLEINEEGFKKSIGMPSYVNLKNRELYIPVSSEYITSNANNEIKMKNLPIYYFIEGMFFALGADKNLRFNDDYETILTYIKDAEICIKSMISKNIKDDKLVEAYLLLKGLYRYNKDLDVMKKLLLVGETIREKDSGFKEIILSDIDYCEEKLLKIPESYLYKTLILKDDGDFKAARVSINEYINLGGTVTEDIKIIINDINNISDYEQAIEYLKDDPAKSIEILLGLLEKFEDNPLIYYYLGVAYRKLENYEKAIYYLTESISKESGILEVVVELGVNYACINDFEAAIKYFKKAFEATKEVEICTNIVMCYMNLNKFEEAKLHLDIAEKLNPEDEIVKELATILKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM6</accession>
    <name>A0A386PHM6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="4">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mglA</name>
        <name evidence="6" type="ORF">CP523_14720</name>
        <name evidence="7" type="ORF">EI377_09680</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676144.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01341"/>
    <dbReference type="EnsemblBacteria" id="AYE35583">
        <property type="protein sequence ID" value="AYE35583"/>
        <property type="gene ID" value="CP523_14720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60968">
        <property type="protein sequence ID" value="QAS60968"/>
        <property type="gene ID" value="EI377_09680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="253"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="499" mass="55575" checksum="47FFBAB5D08B0469" modified="2018-12-05" version="1">MGDSKYVLEMIDICKNFPGVKALDGAKLKVRPGTVHALMGENGAGKSTLMKCLFGVYIEDSGDIFIEGKKINFSNPKQAMENGVAMVHQELNQVLQRDVMDNIWLGRYPGNAGIVNSKKMFDETKKVFDELEIDVNPKIKMAKLSVSQRQMVEIAKAVSYNAKILVLDEPTSSLTQEEVTHLFKIINKLRDRGCGIIYISHKMEEILQISDDVTIMRDGKWIDTIEAKNLTTDKIIKLMVGRDLTNRFPPKTNKPDDVILKVNNLTGTYQPSIQNVSFELRKGEILGVAGLVGSKRTELLETIFGIAHHSEGEIYLHGKLVENTTSQKAIKNGFALLTEERRATGIFGQLSIKFNTIIANIDGYSKFGVLNNKKMTEDTKWTIDSMKVKTPSQKTAIRTLSGGNQQKVIIGRWLLTNPEILLLDEPTRGIDVGAKYEIYQLIIDLAKKGKGVIVVSSEMPELLGICDRILVMSNGRVAGCENTDELSQEDIMTMAAKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP7</accession>
    <name>A0A386PHP7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_08205</name>
        <name evidence="7" type="ORF">EI377_02955</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674698.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34408">
        <property type="protein sequence ID" value="AYE34408"/>
        <property type="gene ID" value="CP523_08205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59813">
        <property type="protein sequence ID" value="QAS59813"/>
        <property type="gene ID" value="EI377_02955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="451" mass="49335" checksum="ECE7666423350255" modified="2018-12-05" version="1">MNKQKRLGEESIPKLLISFSVPAIIGMLVNTFYNIVDRMFIGHIPDIGQLALTGVGVTMPIVSIILGFGLLLGVGTSARVSLNLGLGNKEDAEKLIGNSLTLSIILSVLITFIGLTFSTKLLRSFAASDSTIIYAKDYINIIYFGTIFNLMAFSLNHSIRSDGNPRIAMFSMLIGAITNIVLDPIFIFVLNLGVKGAAIATVISQLVSCIWVISYFTKGKSYIKLRKENLKLEKRIVMAIVTIGMSPFAMQIAQSLVQVIANNSLKMYGGDLAIGAMAIIASITMIFSMPIIGLNQGAQPIIGYNYGAKKYHRVKETVTYGTIIATIIMIIGFILVQLFPHILIRMFNKDPNLVDIATNGLRIFLCMIPFIGFQIVSSSYFQAVGKAKISMFLSLLRQVILLIPFMIILPKFITPSLNGIWIAGAASDLLSAIITGILFYNSVRKLKEVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU6</accession>
    <name>A0A386PHU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3298/DUF4163 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09515</name>
        <name evidence="4" type="ORF">EI377_04260</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676658.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34641">
        <property type="protein sequence ID" value="AYE34641"/>
        <property type="gene ID" value="CP523_09515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60040">
        <property type="protein sequence ID" value="QAS60040"/>
        <property type="gene ID" value="EI377_04260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
        <property type="entry name" value="PdaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PdaC" evidence="2">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="1">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="246" mass="28974" checksum="F78473BBFC9118ED" modified="2018-12-05" version="1">MKLFNRLIITFITILELVHICPQALLINFQPNIVESNCVVDKKITKDYKYLKINVKIPQINCLKNKEQEKVINNEISEWTEMWIMDVEKLAKDYFGAPKVEEPVFPYELTSNYIVKNKNEILSLYIDYYQYTGGAHGITTRKSYNIDMDKGNKIKLANLFKENYDYKCFINKIISEEISKNPNNYFQGKDGFKGISEEQGFYIEDGNLVVYFDYYEIAPYAFGMPEFKIPLKIFKDNLVYDKILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV1</accession>
    <name>A0A386PHV1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04310</name>
        <name evidence="2" type="ORF">EI377_14840</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33749">
        <property type="protein sequence ID" value="AYE33749"/>
        <property type="gene ID" value="CP523_04310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61905">
        <property type="protein sequence ID" value="QAS61905"/>
        <property type="gene ID" value="EI377_14840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="11024" checksum="B30DBDBD4E20083B" modified="2018-12-05" version="1">MEKLRLELINNRHKNQYLNMIEECEEDIKTTGFELYIPISNKDSFEEDMYKLKQRHEGVNLENGWVPESVFWLMNENSNEIIGVIAIRHKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI07</accession>
    <name>A0A386PI07_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">modB</name>
        <name evidence="10" type="ORF">CP523_15660</name>
        <name evidence="11" type="ORF">EI377_10375</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678615.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00559"/>
    <dbReference type="EnsemblBacteria" id="AYE35755">
        <property type="protein sequence ID" value="AYE35755"/>
        <property type="gene ID" value="CP523_15660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61094">
        <property type="protein sequence ID" value="QAS61094"/>
        <property type="gene ID" value="EI377_10375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="219" mass="23978" checksum="365B0FB0C4227756" modified="2018-12-05" version="1">MIKEATFISIKVVIISVIITLIMSLALIKFILDKDTKIRKMIEAFVILPMFIPPSATGYLILLVLGKSGWIGKLIKNLFNTSIIFTISAAIIAAVVVTLPIMYQSIKASIISVDKEVKEAAMICGANDIQIFTKIVLPLSKGGILTGILLSFARAFGEFGATILVAGNIKGKTQTLPMAMFYAIENNNNKEAIQILIIVFTVAIFLMSIYNYLIKNMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI21</accession>
    <name>A0A386PI21_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Argininosuccinate lyase</fullName>
            <shortName evidence="7">ASAL</shortName>
            <ecNumber evidence="3 7">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">argH</name>
        <name evidence="10" type="ORF">CP523_11545</name>
        <name evidence="11" type="ORF">EI377_06360</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02867"/>
    <dbReference type="EnsemblBacteria" id="AYE34997">
        <property type="protein sequence ID" value="AYE34997"/>
        <property type="gene ID" value="CP523_11545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60390">
        <property type="protein sequence ID" value="QAS60390"/>
        <property type="gene ID" value="EI377_06360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11545"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="9">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="466" mass="53011" checksum="AB89A94D555BA173" modified="2018-12-05" version="1">MKLWGGRFKKRVNELVNDFNSSIRIDSKMYKEDIKGSLAHVKMLAKQNIISKNDSEKIIQGLYSILEGLENEVIKIDETSEDIHSFIESTLTYCIGDEGKKLHTGRSRNDQVTLDTKLYLKNYLKSLSLDILDFQTIIYEKAKDNVKTIMPGYTHMQKAQPITLAHHLLAYSEMLKRDLGRILDCYKRLDEMPLGSGALATSTYPIDRNFVANELGFSKVTLNSLDSVSDRDYAIETLSTLSIIMMHLSRFSEEIILWCTNEFNFVELSDEYSTGSSIMPQKKNPDVAELVRGKTGRVYGDLITLLTVMNGIPLAYNKDMQEDKEALFDGLDTVTLSLKTFAAMIKTMKVNKNVMKKSAALGFTNATDVADYLVKKGIAFRNAHEIVGEIVLYCIKENKEIEELPLETLKNFSPIFSKDVYKTIDLITCVEDRKVFGGPSFISVTIQLNFLKDFIEKFQKEIKYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI30</accession>
    <name>A0A386PI30_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14055</name>
        <name evidence="6" type="ORF">EI377_08960</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03087"/>
    <dbReference type="EnsemblBacteria" id="AYE35460">
        <property type="protein sequence ID" value="AYE35460"/>
        <property type="gene ID" value="CP523_14055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60848">
        <property type="protein sequence ID" value="QAS60848"/>
        <property type="gene ID" value="EI377_08960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="126"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="4">
        <location>
            <begin position="432"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="680" mass="75403" checksum="FF715FC8A57BD54B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI47</accession>
    <name>A0A386PI47_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14155</name>
        <name evidence="3" type="ORF">EI377_09060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678533.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35480">
        <property type="protein sequence ID" value="AYE35480"/>
        <property type="gene ID" value="CP523_14155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60866">
        <property type="protein sequence ID" value="QAS60866"/>
        <property type="gene ID" value="EI377_09060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="202" mass="23560" checksum="0BE04873B96CABAF" modified="2018-12-05" version="1">MENKNNKKKIGIAISAITVLVICFCISYFVTDYMRNQEKARIKEEQEEEKTVYNQLSKVVKDSATVILKTEDKIDTEEQMSALKERLNLTGDVTKEMLSEVLGKQGYKIDEMSDMKYIFKRSEEDSNKVEPNKFFIGEKDGFLAVYKSDESGKLAITSEKDVFRDKKRLKDLPEREQNKIKNFEFMYDTREKAIEDITELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI49</accession>
    <name>A0A386PI49_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_01910</name>
        <name evidence="9" type="ORF">EI377_12420</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678304.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01166"/>
    <dbReference type="EnsemblBacteria" id="AYE35795">
        <property type="protein sequence ID" value="AYE35795"/>
        <property type="gene ID" value="CP523_01910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62215">
        <property type="protein sequence ID" value="QAS62215"/>
        <property type="gene ID" value="EI377_12420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="23615" checksum="AC8481D0359063D1" modified="2018-12-05" version="1">MNDIISLMPQIFEGFKMTLGVFALTLVLSIPLGIIIALGRISKIRFLKSITGAYVLILRGTPLLLQILFVFFGLPLIGVKVPRFTAAILAMVLNYGAYFAEIFRAGILSIDKGQFEAAEVLGLTPKDTFFRIILPQALKKIFPPVANEVVTLVKDTALVYVVGLDELLKVAKIASNRLSSIMPFVVVAVVYLVFNGILTKVLEKIEKRYNYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI83</accession>
    <name>A0A386PI83_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11885</name>
        <name evidence="3" type="ORF">EI377_06705</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673441.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35057">
        <property type="protein sequence ID" value="AYE35057"/>
        <property type="gene ID" value="CP523_11885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60450">
        <property type="protein sequence ID" value="QAS60450"/>
        <property type="gene ID" value="EI377_06705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="127" mass="12952" checksum="D7138B65D6528A20" modified="2018-12-05" version="1">MEMNEILNGLNSCGCNDGSTSQGSSQCIPSFDSCCGNGCGFGSWIWILLILFYSNGSCMWGNNGCGCGCGCESKKSCGCCCGNGYGNNNGSCSSYLFLLVILFLCAGCGFGGCGSDNGNLGNLFGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC7</accession>
    <name>A0A386PIC7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1622 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675909.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34362">
        <property type="protein sequence ID" value="AYE34362"/>
        <property type="gene ID" value="CP523_07960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07960"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38468">
        <property type="entry name" value="PTHR38468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="107" mass="11983" checksum="5FBD98C6AADE539A" modified="2018-12-05" version="1">MLENFVSTVVPIGIHLLEAMGIVIVIIGAIKAFYKYTLNLLAQKNYSIKIEFAKSLTLALEFKLGAEILKTVIVRSLDEMYILAAIILLRAILAFVIHLEIKADEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE4</accession>
    <name>A0A386PIE4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell shape-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13445</name>
        <name evidence="3" type="ORF">EI377_08340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    <reference evidence="4" key="1">
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            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
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    <reference evidence="2" key="2">
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00786"/>
    <dbReference type="EnsemblBacteria" id="AYE35873">
        <property type="protein sequence ID" value="AYE35873"/>
        <property type="gene ID" value="CP523_13445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62183">
        <property type="protein sequence ID" value="QAS62183"/>
        <property type="gene ID" value="EI377_08340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="524" mass="58967" checksum="5D4E9D9EE1F39231" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF3</accession>
    <name>A0A386PIF3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3783 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08110</name>
        <name evidence="2" type="ORF">EI377_02865</name>
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    <organism evidence="1 3">
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        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Clostridium</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675965.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00736"/>
    <dbReference type="EnsemblBacteria" id="AYE34392">
        <property type="protein sequence ID" value="AYE34392"/>
        <property type="gene ID" value="CP523_08110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59797">
        <property type="protein sequence ID" value="QAS59797"/>
        <property type="gene ID" value="EI377_02865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014543">
        <property type="entry name" value="UCP014543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="122" mass="14450" checksum="C7A23205D38957F7" modified="2018-12-05" version="1">MLDNNKCILTYRIPQKELNTLQIEEIKIIEISPEIVEMKIIDILEGFRFPTFNPYPIREKVILFNNFSDRELKSTIKDIRKNTKDGLLAVVTPTSIEWKFNDLVKHLVEEKEWFLNQQKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF7</accession>
    <name>A0A386PIF7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11205</name>
        <name evidence="4" type="ORF">EI377_05995</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677048.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00899"/>
    <dbReference type="EnsemblBacteria" id="AYE34934">
        <property type="protein sequence ID" value="AYE34934"/>
        <property type="gene ID" value="CP523_11205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60328">
        <property type="protein sequence ID" value="QAS60328"/>
        <property type="gene ID" value="EI377_05995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="74"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="293"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="444" mass="51981" checksum="1D8C561E2AFDBE52" modified="2018-12-05" version="1">MHFNDERDKLLKEAIKFEGKSDVTSEFKRSFFHLIEGIIVEMLEKEDNFFGQFMVKIKRDIRLDITYPLATIPQFDGFKMFFNPLLFLNYDKKEMCALFKHEIYHIMYNHYEEEKKLKNKYTTMAVNLALDISINQFIKDLPMESYKVDRVNREFGLNLKDDKVAEIYAKEIDKVLKSKLNNKIESKNSNIARVIDISKAHDIWSDSSLNKDAIRGMTKKTAISSFKGKIPKDIEKIIISYTEKPEISWQDILKKLIPSLRAGERKTITRRNRRQPERLDLRGVLPNSIPEILVAIDISASISDDEVQKIMIEILEITKMRRNKITIIECDNEIRRVYKIKSRNDIKKRLNNTGATKFSPIFRFIKENNLRNHILIYFTDGVGEKELDTKPINSNIIWVLTGHEELSLNCSYGQVKRISGKVNKSEGGNSGLEMYRELQHDWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG6</accession>
    <name>A0A386PIG6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 4,6-dehydratase (Inverting)</fullName>
            <ecNumber evidence="4">4.2.1.115</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pseB</name>
        <name evidence="3" type="ORF">CP523_10890</name>
        <name evidence="4" type="ORF">EI377_05685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.115" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677635.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02512"/>
    <dbReference type="EnsemblBacteria" id="AYE34871">
        <property type="protein sequence ID" value="AYE34871"/>
        <property type="gene ID" value="CP523_10890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60266">
        <property type="protein sequence ID" value="QAS60266"/>
        <property type="gene ID" value="EI377_05685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020025">
        <property type="entry name" value="PseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03589">
        <property type="entry name" value="PseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="342" mass="39202" checksum="243880C6C3FA0FC6" modified="2018-12-05" version="1">MLNNKVILITGGTGSFGKKFTKRILDSFNPKKIIIYSRDEFKQDLMKKEFMVKYPEKANKLRFFIGDIRDKDRLYRAFKGVDYVIHAAAMKQVPACEYNPFEAIKTNINGAQYIVDAAIDCNVKKVVALSTDKAVNPINLYGGTKLVSDKLFISANAYSGEEGTIFSVVRYGNVAGSRGSVIPFFKALIESGNKELPITDFNMTRFWITLDEGVDLVFKALKESKGGETYISKIPSFKITDLAKAMLQDVDMKEVGIREGEKLHEVMITKDDSRSTYEYDKHYIVYPHFDWWHFESHFTEGGKLIERGFEYNSGANTEWLSIEDLRVEMKKLNLYDFDKYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII3</accession>
    <name>A0A386PII3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ORF">CP523_10990</name>
        <name evidence="8" type="ORF">EI377_05785</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677669.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02532"/>
    <dbReference type="EnsemblBacteria" id="AYE34891">
        <property type="protein sequence ID" value="AYE34891"/>
        <property type="gene ID" value="CP523_10990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60286">
        <property type="protein sequence ID" value="QAS60286"/>
        <property type="gene ID" value="EI377_05785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="288" mass="32084" checksum="D82DC9E1001F015B" modified="2018-12-05" version="1">MKGIILAGGSGTRLYPVTKAMSKQMVPIYDKPMIYYPMSVLMLAGIRDILIISTPRDIINFKELFKDGSELGLNIEYAIQEAPNGLAEAFIIGEDFIGSDNVAMILGDNIFYGQSFSERLKEASELKEGAMVFGYYVQNPKAFGVVEFDSEGKVISLEEKPENPKSKYAVPGLYFYDNSVVKKAKELKPSARGELEITDLNRVYMEEGNLTVNLLGRGMAWLDTGTHASMLQASNFVEAVQNTQGTYIACLEEIAYRKGWISQDEVKELAKPLLKTGYGKYLMDIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP1</accession>
    <name>A0A386PIP1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05515</name>
        <name evidence="2" type="ORF">EI377_00135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679082.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33969">
        <property type="protein sequence ID" value="AYE33969"/>
        <property type="gene ID" value="CP523_05515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59360">
        <property type="protein sequence ID" value="QAS59360"/>
        <property type="gene ID" value="EI377_00135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="100" mass="12089" checksum="9067CD80A998FC75" modified="2018-12-05" version="1">MKERIKKVIEQRKKLNMNDDMGIQKCWEDITDILSENEEDTIAYLNNCDKDELYWISEVFEDISENLQSQEFIECLRRLDVKFPELDMTKDIDLAEEYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT4</accession>
    <name>A0A386PIT4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_15625</name>
        <name evidence="7" type="ORF">EI377_10340</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678623.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00566"/>
    <dbReference type="EnsemblBacteria" id="AYE35750">
        <property type="protein sequence ID" value="AYE35750"/>
        <property type="gene ID" value="CP523_15625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61087">
        <property type="protein sequence ID" value="QAS61087"/>
        <property type="gene ID" value="EI377_10340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="313"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="408" mass="45395" checksum="14A0F43A7A04E9D8" modified="2018-12-05" version="1">MKYVVIGASAAGISGAKTLRELDENAEITLVSKDEYVYSRCILHHYISNHRNIKELNFADENFFTNNNINWIKGVEVISLDEKNQKIVLSNNNILSYDKILIASGASSFIPPIVNLREANRVVGLRNLEDAILIKNEINNIKNVVVLGAGLVGIDAISGLLESGLNVSLVEMGDKILPLQLDKYTSKVYEEKFKEKGVNLKLNVKAEKLIIDENKNPKALLLNTGEEIPCELVIVATGVRANIGFINETEVATDRFGLIINEKGETNITNVYGAGDVTGRNPIWPTAVKEGIIAANNMLNNSLIMTDFFGSKNTMNFVGIATMSLGITEAPDDSYKVEIRRDKDNYKKIIHKDGKIYGSIIQGDLSYAGVLTQLIKEKIDISKVKKNIFDIDYSDFFNIEENFEYSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU5</accession>
    <name>A0A386PIU5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11850</name>
        <name evidence="3" type="ORF">EI377_06670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673428.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02928"/>
    <dbReference type="EnsemblBacteria" id="AYE35051">
        <property type="protein sequence ID" value="AYE35051"/>
        <property type="gene ID" value="CP523_11850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60444">
        <property type="protein sequence ID" value="QAS60444"/>
        <property type="gene ID" value="EI377_06670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="31306" checksum="DD8266B27F86D6B2" modified="2018-12-05" version="1">MAKPSIFSKEYNSHMKKRKRNRNILISSIILLVIIGLGVFKFNEKLISFSDIKMKIQSLFNKGEETLDEKNKDTEVIHPNIDEQVKEESKKDEKKILELSINGDRKLKMEYEEKDNKRTFKDIVEMPQGIYYDISPLKEFLLIIDENQNINLFNTKGEAKNITSPTYVAPNGEKFEKDTILKIYKEHIWNKDAKFISNTKVAYISNIPYFGYNLNKYIWIVDIQNNTHTTLWNSKAKDIEFLGHSDKGLEVTINGNKKYINDNGQLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW3</accession>
    <name>A0A386PIW3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Arginine ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_06035</name>
        <name evidence="9" type="ORF">EI377_00515</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01908"/>
    <dbReference type="EnsemblBacteria" id="AYE34059">
        <property type="protein sequence ID" value="AYE34059"/>
        <property type="gene ID" value="CP523_06035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59430">
        <property type="protein sequence ID" value="QAS59430"/>
        <property type="gene ID" value="EI377_00515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="227" mass="24848" checksum="A7B2AE2FA310FE5F" modified="2018-12-05" version="1">MLNLDFSFVSKYLPVFIDGAKITLVISFITVLFGVLFGSVLFFMKSSNIHIGKFKPLKIIASIYIEIVRGTPMLLQILMVYSGSKMIFDIDISAFASAIIAISLNSAAYVSEIVRAGIEAVDKGQLEAARSLGMTQAMAMRLVVIPQAIRNILPAIGNEFVTIIKESSMASVIGVGELMFSAKVVTGATYLGFEPLIIAAVFYFIMTFSLGRLMSYIERRLKVSDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW9</accession>
    <name>A0A386PIW9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ComEC/Rec2 family competence protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02330</name>
        <name evidence="9" type="ORF">EI377_12850</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674085.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00501"/>
    <dbReference type="EnsemblBacteria" id="AYE35800">
        <property type="protein sequence ID" value="AYE35800"/>
        <property type="gene ID" value="CP523_02330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61551">
        <property type="protein sequence ID" value="QAS61551"/>
        <property type="gene ID" value="EI377_12850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="182"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="565" mass="65628" checksum="84BAF3808EFD6D30" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX3</accession>
    <name>A0A386PIX3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF454 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12065</name>
        <name evidence="3" type="ORF">EI377_06895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673489.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02970"/>
    <dbReference type="EnsemblBacteria" id="AYE35091">
        <property type="protein sequence ID" value="AYE35091"/>
        <property type="gene ID" value="CP523_12065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60484">
        <property type="protein sequence ID" value="QAS60484"/>
        <property type="gene ID" value="EI377_06895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007401">
        <property type="entry name" value="DUF454"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35813">
        <property type="entry name" value="PTHR35813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04304">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016789">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="129" mass="14699" checksum="D8C09D3BB351C0A3" modified="2018-12-05" version="1">MNKVKRGIYVAIGLICVVLGSIGVIIPILPTTPFLLLASFCFVRGSERFDKWFKGTKLYKKHLESFVNSRSMTLKTKITILLFADTMIAFPLIIVDSITVKVILSLVILFKFYYFIFRIKTIKPTTINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ12</accession>
    <name>A0A386PJ12_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09200</name>
        <name evidence="9" type="ORF">EI377_03945</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03058"/>
    <dbReference type="EnsemblBacteria" id="AYE34586">
        <property type="protein sequence ID" value="AYE34586"/>
        <property type="gene ID" value="CP523_09200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59986">
        <property type="protein sequence ID" value="QAS59986"/>
        <property type="gene ID" value="EI377_03945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HisKA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
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            <begin position="12"/>
            <end position="31"/>
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            <end position="223"/>
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            <end position="277"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="309"/>
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    </feature>
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        <location>
            <begin position="376"/>
            <end position="591"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="591" mass="67849" checksum="FDBE6A44C41BB817" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
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    <name>A0A386PJ65_CLOSE</name>
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        </submittedName>
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        <name type="scientific">Clostridium septicum</name>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 9">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="149"/>
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            <end position="353"/>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="359" mass="41899" checksum="04E5A35750CC8889" modified="2018-12-05" version="1">MDYNITYRQKDKGWQYIISYKVNGKWKQKSKQGFSTKKEAKPFAEKALKELKTAYENEKNIINENYDSITFKELTDIYIEHSKLYKEYNTIRSYINYAKAFKSLNDMKVISINKGTIQKAVDSLVTTKLSSSTIKEYLKRSTLFFKYYIENYNPNYSNPTRNIVLPKIEKAQNKKALTKKELDLLLKSLKKENYDFYIISLLAGTCGLRAGEILGLTWNDIDEINSTLNINKQWKRLDRKIYGFGRLKSNNSNRIVPLPQKTLKELKEYHLSLVVDINNRILPFNETKIYNLNTKLKQLSDISIHELRHTYATLLISNGIDFKTAADILGHDVEQLIKTYSHVTDDMMTKATNKIAKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ75</accession>
    <name>A0A386PJ75_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12805</name>
        <name evidence="3" type="ORF">EI377_07680</name>
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    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678193.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02798"/>
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        <property type="protein sequence ID" value="AYE35231"/>
        <property type="gene ID" value="CP523_12805"/>
    </dbReference>
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        <property type="gene ID" value="EI377_07680"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="34000" checksum="3E685A96243059EB" modified="2018-12-05" version="1">MLNKVTDRVYYMDYVEQGDRAVIGLVIGDNYSLVIDGGNSKEHAEKFLEYVSKLNIPKIKYLVLTHWHWDHVFGIKTINAINIVQKESNEKIKWLKTLKWTDEAIDERVKNGEEIDFCREHIKIEMPNSNRNIEIPSADIVFNEEIEIDLGGIIVKAIHIPCDHSNDSTIIWIPKEKVTFLGDALYLDMYHGEWSYSREKFYPLLEKLKNQKSNYYIPAHHPKYDNNSFNEFVSYQISIGDLVGEETSIENVKKAFEFKNKRNPNEQELEDLKVFVNGNRKNLIIDNWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJK5</accession>
    <name>A0A386PJK5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA_27 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10500</name>
        <name evidence="5" type="ORF">EI377_05285</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674209.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01400"/>
    <dbReference type="EnsemblBacteria" id="AYE34796">
        <property type="protein sequence ID" value="AYE34796"/>
        <property type="gene ID" value="CP523_10500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60191">
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        <property type="gene ID" value="EI377_05285"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038734">
        <property type="entry name" value="YhaN_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13514">
        <property type="entry name" value="AAA_27"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_27" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="709"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="917" mass="107429" checksum="3537140C5376D7C7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJM7</accession>
    <name>A0A386PJM7_CLOSE</name>
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        <submittedName>
            <fullName evidence="7">Tryptophan-rich sensory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_13765</name>
        <name evidence="8" type="ORF">EI377_08655</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
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        <property type="protein sequence ID" value="AYE35411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02069"/>
    <dbReference type="EnsemblBacteria" id="AYE35411">
        <property type="protein sequence ID" value="AYE35411"/>
        <property type="gene ID" value="CP523_13765"/>
    </dbReference>
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        <property type="gene ID" value="EI377_08655"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TspO/MBR-related_sf"/>
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        <property type="entry name" value="TspO_MBR"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="59"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="191" mass="22740" checksum="950CC929FBB9123F" modified="2018-12-05" version="1">MRGKEKKIKDNRKKVKKINKRKSNHNINIFKVNGEFKVIPLLMNILIPVLGGVIIGYLNKNTMNTYEMLKKPIFTPPNNVFPIVWTILYLLMGVAAYRVYMRNKQGADDKGAYFFYLVQLMFNFMWSFIFFTFRLYGIAFIWLVVLFILVLITFIKFIRVDKIAAILLIPYMIWLMFAGILNFFIWMFNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN9</accession>
    <name>A0A386PJN9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12415</name>
        <name evidence="4" type="ORF">EI377_07300</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE35158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675342.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02030"/>
    <dbReference type="EnsemblBacteria" id="AYE35158">
        <property type="protein sequence ID" value="AYE35158"/>
        <property type="gene ID" value="CP523_12415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60561">
        <property type="protein sequence ID" value="QAS60561"/>
        <property type="gene ID" value="EI377_07300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
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        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="98" mass="10153" checksum="A2F7F86C7CEBAB14" modified="2018-12-05" version="1">MRYYGNEALGLVETIGLVPALHAADQMLKAANVELISYENVGSTLVTVMVKGDVGAVKSAVEAGARAAASVGKLTAHNVMPRPIKPVGDIVSVHDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS8</accession>
    <name>A0A386PJS8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675196.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01972"/>
    <dbReference type="EnsemblBacteria" id="AYE35208">
        <property type="protein sequence ID" value="AYE35208"/>
        <property type="gene ID" value="CP523_12685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="365" mass="42038" checksum="13781D406228286B" modified="2018-12-05" version="1">MPMNIIIQEKRKEIGLTQEQIGQYLGVSTPAVNKWEKGYTYPDVSLLPALARLLKVDLNTLLCFNEGLTEQEIGNFSNEVIDIINTKGFEVGFNKSIEKIQEYPSCDMLIYSMAMLLDGALIIYGVGIEDKEYYKKQIKILYERVAKSDNDKVRDKAVYMLVSKYIDCMEYEKAQEMLDLLPERTVLDKTQLQANLFIKQEKLHEAARMLEGKLLNIVNEVQMILMSLAEIEIKEGDSQNASHLAELSQKVIKLFELGDMQALATPLQVAILQKNIEESISLLKAYFSATFKLWDVSKSSLYRHIAADMKTVKTVKEELVKEKKNTLGKQLRLTLLSELENNPEYIFLHSNTEFRQFIKKYRSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX0</accession>
    <name>A0A386PJX0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cardiolipin synthase</fullName>
            <shortName evidence="12">CL synthase</shortName>
            <ecNumber evidence="12">2.7.8.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls</name>
        <name evidence="14" type="ORF">CP523_11365</name>
        <name evidence="15" type="ORF">EI377_06185</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol</text>
            <dbReference type="Rhea" id="RHEA:31451"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phospholipase D family. Cardiolipin synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02830"/>
    <dbReference type="EnsemblBacteria" id="AYE34962">
        <property type="protein sequence ID" value="AYE34962"/>
        <property type="gene ID" value="CP523_11365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60356">
        <property type="protein sequence ID" value="QAS60356"/>
        <property type="gene ID" value="EI377_06185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01916">
        <property type="entry name" value="Cardiolipin_synth_Cls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030874">
        <property type="entry name" value="Cardiolipin_synth_Firmi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS60356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="480" mass="56037" checksum="7340B9B7586C0681" modified="2018-12-05" version="1">MSITIVGITILLTIIYIINIICSVSLIFIERKEPTTTWAWLLILAVLPGVGFIAYLTFGQNLSRQKIFREKKVIDERKAKELRDKFKEYNKAHKIREEYVDLIKMNYNHSGSLYTTGNKVKTYINGEDKFRDLLQDIKRAKKFIHIEYYIFRMDGLGKTILNELKKKIDEGVEVRLLVDGMGSKNIRTKHIKYIKNLGIKFAIFFPGILPYLNIRINYRNHRKIVVIDGEVGYVGGFNVGDEYINKGTQFEFWRDTHIRVQGEAVNELNKRFILDWDYADEEEFKDYEKYFPKQESYGDVGIQIVSSGPDHREEYIKNAYMKIINNAKERVYIQTPYLVPDEPMMEALKIAALSGVDVRIIVPGEPDHFFMEWMLSSNIGDLLEVGVKIYRYQRGFIHSKTIVADGKVSSIGTANLDIRSFKLNFEINTVIYDEEFSKKQEQIFFKDEQDCKLVTREEYESRSRGLKIKEAIIRLIAPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK14</accession>
    <name>A0A386PK14_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ORF">CP523_09065</name>
        <name evidence="8" type="ORF">EI377_03810</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008681171.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00252"/>
    <dbReference type="EnsemblBacteria" id="AYE34559">
        <property type="protein sequence ID" value="AYE34559"/>
        <property type="gene ID" value="CP523_09065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59959">
        <property type="protein sequence ID" value="QAS59959"/>
        <property type="gene ID" value="EI377_03810"/>
    </dbReference>
    <dbReference type="GeneID" id="66300472"/>
    <dbReference type="KEGG" id="csep:CP523_09065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="59" mass="6621" checksum="8C3C6190130B2DAD" modified="2018-12-05" version="1">MAKIKVTLVKSLIGRKKDHIATAHALGLKKIGKTVEHEETPQIRGMINKVDYLLKVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK24</accession>
    <name>A0A386PK24_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">CP523_09115</name>
        <name evidence="11" type="ORF">EI377_03860</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678382.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00261"/>
    <dbReference type="EnsemblBacteria" id="AYE34569">
        <property type="protein sequence ID" value="AYE34569"/>
        <property type="gene ID" value="CP523_09115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59969">
        <property type="protein sequence ID" value="QAS59969"/>
        <property type="gene ID" value="EI377_03860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="206" mass="23682" checksum="2CCEFE5CDF51DF75" modified="2018-12-05" version="1">MARYTGATCRLCRREGMKLFLKGDRCYTDKCAFVRRSYAPGQHGAAKKKMSNYGVQLREKQKARRIYGVLEGQFRTYYEKADHMRGITGENLLMLLEMRLDNVVYRLGYGASRNEARQLVTHGHFLVNGKKVDIPSFKVSVNDVITVCEKSRGTEKFKTFVENPKTLPKWLEANVDNYEGKVIAEPTREDIDVPVNETLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK44</accession>
    <name>A0A386PK44_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tig</name>
        <name evidence="14" type="ORF">CP523_11855</name>
        <name evidence="15" type="ORF">EI377_06675</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673430.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02929"/>
    <dbReference type="EnsemblBacteria" id="AYE35052">
        <property type="protein sequence ID" value="AYE35052"/>
        <property type="gene ID" value="CP523_11855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60445">
        <property type="protein sequence ID" value="QAS60445"/>
        <property type="gene ID" value="EI377_06675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS60445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="426" mass="48079" checksum="6E81259D488273B8" modified="2018-12-05" version="1">MEAKMEKIDTNVVKFEVTVEAKKFQEALNKAYNKNAKHFNVPGFRKGKVPMAIVKKYYGVGVLIEDAVNFAIESSYPEVLKENNIIPVDYPKVDILTAEEGKDFVYTAEVTIYPEVQLGEYKGLKVEKASYSVSEDEVNAKLKEMQEKNARIESKEDGAIEKGNLAVIDFKGYVDGEAFQGGEGSDYTLEIGSGTFIDNFEDQLVGAKTGDKVEVNVTFPENYGKEELNGKPAKFEVTVKDIKVKELPELDDEFAKEVSEFDTLAEVKEDITKKLEEANKAREEKEYEEAIISAVVANAKIDVPEVMINKEIDSMVKNLEQRLQYQGLTLEQYFQFTGTDASKMRDYMKENAEKKVRTDLVLEAVEKAENIEVTEEELRTRAEEVAKMYSAGDEKMINLLLENQKEALTTDVKAGKTVKFLVENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK64</accession>
    <name>A0A386PK64_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glmS</name>
        <name evidence="11" type="ORF">CP523_09370</name>
        <name evidence="12" type="ORF">EI377_04115</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02731"/>
    <dbReference type="EnsemblBacteria" id="AYE34619">
        <property type="protein sequence ID" value="AYE34619"/>
        <property type="gene ID" value="CP523_09370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60019">
        <property type="protein sequence ID" value="QAS60019"/>
        <property type="gene ID" value="EI377_04115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 12" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="453"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="608" mass="67351" checksum="DA6D37D543AC42AF" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKE7</accession>
    <name>A0A386PKE7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12200</name>
        <name evidence="7" type="ORF">EI377_07020</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673567.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02995"/>
    <dbReference type="EnsemblBacteria" id="AYE35116">
        <property type="protein sequence ID" value="AYE35116"/>
        <property type="gene ID" value="CP523_12200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60507">
        <property type="protein sequence ID" value="QAS60507"/>
        <property type="gene ID" value="EI377_07020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="6215" checksum="DFA19497B754ED99" modified="2018-12-05" version="1">MKAFVDENVCISCGLCEGTCSEVFSLDTGVAVAGEVVEGTEDLVREACDGCPVQAISVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKH8</accession>
    <name>A0A386PKH8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674262.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34769">
        <property type="protein sequence ID" value="AYE34769"/>
        <property type="gene ID" value="CP523_10345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="509" mass="59725" checksum="5D2B240C5911A7FE" modified="2018-12-05" version="1">MFSLWYKLAFLDGDIISKIKKIIKSICIYILPTIVAIIVSDKVLIRVQYNLFGTVTNIIVFNLLYSSIIHIYIQKKTLSSLQGDVIVKFVPQKFNVYIILRVLMVFIKTYLPIITLSILTFKDIFINPVYIFYICSLAFIISIIFLNVIIAILYRYLLNIVNKLIYKLINFITFIYITSLVIYQSTVTPIWYLESLERYLKKEDLILNKIDINFFQIMLILIIFILSIMSINFLKNFLKIRGRNLIFIKNISVNEKSNKITKVIEDYCEKVYSIYFSNIEKSFFVKDIKEAVRTNKYSLFFICLYHIINICFILFFFFADNINSIEISIISVKISLSITIVQILISYFLGKASFEKNINIDTDYKVLKNYNIRVAMNGIIKVKTKVLSAIVFPKVVSVFCIIIISSLIIYSNTYLALIYFILMLQLLFLKEIIGLWLIKSINKFNSNKMIIKILNFILIGITLVILINLYFYTQIIQFIYGQLVLLVILIVLYLFNLFINKERINVRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI1</accession>
    <name>A0A386PKI1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12920</name>
        <name evidence="7" type="ORF">EI377_07800</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678223.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35252">
        <property type="protein sequence ID" value="AYE35252"/>
        <property type="gene ID" value="CP523_12920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60647">
        <property type="protein sequence ID" value="QAS60647"/>
        <property type="gene ID" value="EI377_07800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="458" mass="50009" checksum="22F261D8AD466AB2" modified="2018-12-05" version="1">MSRGTTNLGKDPVGNLLFKLALPAIIAQLVNVLYNIVDRIFIGRIPNGDLAMAGVGVVFPIIMIISAVSALVGMGGAPLAAIKMGEEDNEGAERIISNSFTMLIVLGVLLTIGFLIFKEPILWTFGASEATIGFSNDYLTLYLIGTVFVQIALGMNPFINTQGFAKTGMVTVMIGAVINIILDPIFIFGLDMGVKGAALATILAQIISAIWVLVFLFGKKSIIKIRKKYLVPNIKIIGSIIALGISPFIMQATESLVLITLNNKLFMYGRDLAVGAMTIMSSVMQIVILPLMGLSQGAQPIISYNYGSKNSKRVKKTFKLLLISCLAYTGVMWALLMLFPQVFVNIFNNKPELVEITSWSIRIYFAGIFMFGAQIACQQTFLALGQAKISLMLALLRKIILLIPFIFILPTFFNNKLMGVLMAEPFADVIAALITIISFIIFYKKTFNTKNLEKLIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM4</accession>
    <name>A0A386PKM4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chloramphenicol resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679056.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01956"/>
    <dbReference type="EnsemblBacteria" id="AYE35312">
        <property type="protein sequence ID" value="AYE35312"/>
        <property type="gene ID" value="CP523_13240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="144" mass="16762" checksum="5307A5DF3DFF838C" modified="2018-12-05" version="1">MIIDSLRNYIKKCPCLDTFNNAIKVNVNYLEPYADTYSIEEVPIEPIVKKYVNGDSIRQYAFIFTSRKPYGVDVLQNIDNSGFYEKFADWIEDNNNNNYIFPLLDNKLEPLEVKVTSTGYAFAVTEDTAQFQIQLKLKYFKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKT4</accession>
    <name>A0A386PKT4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.187</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">N-acetylmannosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmannosamine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14805</name>
        <name evidence="4" type="ORF">EI377_09765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-beta-D-mannosaminyl-(1-&gt;4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:16053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:62959"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:132210"/>
            <dbReference type="EC" id="2.4.1.187"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; teichoic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 26 family. TagA/TarA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.187" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676110.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01322"/>
    <dbReference type="EnsemblBacteria" id="AYE35598">
        <property type="protein sequence ID" value="AYE35598"/>
        <property type="gene ID" value="CP523_14805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60984">
        <property type="protein sequence ID" value="QAS60984"/>
        <property type="gene ID" value="EI377_09765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14805"/>
    <dbReference type="UniPathway" id="UPA00632"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02070">
        <property type="entry name" value="TagA_TarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034714">
        <property type="entry name" value="TagA_TarA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="243" mass="27837" checksum="26BFE515E2F55C78" modified="2018-12-05" version="1">MKQKDFVDILGYRIYKKTLKECLRYIETFPKVHIVSGNPEVLYTGLNNEALLNNFKSNNSLIIPDGVGTQLAAKILKKDIAEKIAGIELMKAIIKNCEKNKRGIYLLGASEESLNACVANLVTNYPALNIVGYRNGFFDMNNAKEVLEEINKNKPYAIFVAMGCPRQEEFITKYMNYLDVKVFMGVGGSFDVIGEKVKRAPKWMIKIGLEWFYRVAKEPWRIKRLGSIPKFLWLVIKEKKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKU1</accession>
    <name>A0A386PKU1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="8">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murE</name>
        <name evidence="13" type="ORF">CP523_14865</name>
        <name evidence="14" type="ORF">EI377_09820</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01310"/>
    <dbReference type="EnsemblBacteria" id="AYE35608">
        <property type="protein sequence ID" value="AYE35608"/>
        <property type="gene ID" value="CP523_14865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60995">
        <property type="protein sequence ID" value="QAS60995"/>
        <property type="gene ID" value="EI377_09820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14865"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="109"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="325"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="8">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="8">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="8">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="480" mass="54119" checksum="EE7985B57CB496A5" modified="2018-12-05" version="1">MKLIELLNGVKYELLKGTLDKKISHLQYDSRKIVEDDIFVCLKGFEVDGHNYANKAIELGAKVIICERDIEVNKDDVTVIKVKEGRKALSIMSANYYDNPSKKLKLIGVTGTNGKTTSVYLLKSILEKAGKKVGLVGTVANYIGDKKLKSERTTPESLELQKLFKDMVEAGCEYCVMETSSHSLELNRVYGCHYEVGIFTNLTRDHLDFHKSFDNYYNAKFKLFENSKSVVINVDDNYGYRVLNDVKELNDKNIITYSIENDSDIKASDIKLKEGDIHFKVNGIEFNSVLPGEYNIYNALGVIGAMKAEGIDDKYIKEGLMDVVVPGRCERVGYKYNIPYEIIIDFAHTPDGLKNILETLRNFTKNRLIAVYGCGGDRDKVKRAELGRIGTEIADLAIITSDNPRNEDPMAIIRDIVCGINKTNYLAIENRIEAIKLAISMAEEGDVIVLAGKGHESYQITNEGYIHFDEREIVDEILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKW7</accession>
    <name>A0A386PKW7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">trmB</name>
        <name evidence="2" type="ORF">CP523_13370</name>
        <name evidence="3" type="ORF">EI377_08260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677521.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00769"/>
    <dbReference type="EnsemblBacteria" id="AYE35336">
        <property type="protein sequence ID" value="AYE35336"/>
        <property type="gene ID" value="CP523_13370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60727">
        <property type="protein sequence ID" value="QAS60727"/>
        <property type="gene ID" value="EI377_08260"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13370"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="25853" checksum="03D8A3BBC80AC47B" modified="2018-12-05" version="1">MRLRKKPWARPELESCPFFIINPSENRGKWKEIFGNNKPIYLELGCGKGTFIAVHGSENKDINYIAIDIKDEVLVLAKRNIEKAYSEKNEELDNIKLMAQEILIIDKILDSKDEISRIYINFCNPWPKDRHKKRRLTHTRQLEHYKTFLKDNGEIYFKTDDDELFDESLEYFKESGFNIEYITYDLHNSDFEGNVETEHEKMFTEMGIKTKFLIAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKX0</accession>
    <name>A0A386PKX0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11350</name>
        <name evidence="3" type="ORF">EI377_06170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673253.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34959">
        <property type="protein sequence ID" value="AYE34959"/>
        <property type="gene ID" value="CP523_11350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60354">
        <property type="protein sequence ID" value="QAS60354"/>
        <property type="gene ID" value="EI377_06170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="87" mass="9790" checksum="FB3EEB39B1F6D916" modified="2018-12-05" version="1">MFNNIFKNKNKLIKIMHTILFIITGLYILESIFLMGLFTNPILACINIIVGIITLVIAIIKNENKLALIDLAILLGTSAIFIYLIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKY8</accession>
    <name>A0A386PKY8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11455</name>
        <name evidence="3" type="ORF">EI377_06270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02848"/>
    <dbReference type="EnsemblBacteria" id="AYE34979">
        <property type="protein sequence ID" value="AYE34979"/>
        <property type="gene ID" value="CP523_11455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60372">
        <property type="protein sequence ID" value="QAS60372"/>
        <property type="gene ID" value="EI377_06270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="186" mass="21798" checksum="43F7C142EB280C9E" modified="2018-12-05" version="1">MKELETRIIDIDVDSIRKKLNSLKAKKVKEEYQINDIYDFQDRRLLNSKGYARIRTVDDKLNNKEVIYMTTKKMLSQDTFKVMEENETIVLDKYMARKIFLSLGLVLQESIKKYRESYLINDSLVEIDINDKDFCPFPYLEIETSSEEKLKEILNLLGYSIKDTTSKTIYEILSEKGINPSNGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKZ0</accession>
    <name>A0A386PKZ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_14215</name>
        <name evidence="9" type="ORF">EI377_09120</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
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        <property type="protein sequence ID" value="AYE35492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_066678505.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00279"/>
    <dbReference type="EnsemblBacteria" id="AYE35492">
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        <property type="gene ID" value="CP523_14215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60878">
        <property type="protein sequence ID" value="QAS60878"/>
        <property type="gene ID" value="EI377_09120"/>
    </dbReference>
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    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NT_Rel-Spo_like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="386"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="653"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="727" mass="83247" checksum="AC72D03E952DB0F9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL69</accession>
    <name>A0A386PL69_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Antibiotic ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_14135</name>
        <name evidence="9" type="ORF">EI377_09040</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03103"/>
    <dbReference type="EnsemblBacteria" id="AYE35476">
        <property type="protein sequence ID" value="AYE35476"/>
        <property type="gene ID" value="CP523_14135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60863">
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        <property type="gene ID" value="EI377_09040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="541"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
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            <begin position="123"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
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            <begin position="470"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="697" mass="77199" checksum="600AA76386F17952" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLA2</accession>
    <name>A0A386PLA2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05530</name>
        <name evidence="2" type="ORF">EI377_00150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35828">
        <property type="protein sequence ID" value="AYE35828"/>
        <property type="gene ID" value="CP523_05530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59361">
        <property type="protein sequence ID" value="QAS59361"/>
        <property type="gene ID" value="EI377_00150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032869">
        <property type="entry name" value="WHH_dom_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14414">
        <property type="entry name" value="WHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="148" mass="16315" checksum="93D57B232DE4494F" modified="2018-12-05" version="1">MGYLPEIANKIKNGERVERIVDSIRGSKGAAKADLDGIRIINKKYAGKTYELTGDLAKKYPNGVKFSEEGFPNFEPYSIKKVTVNNLEGDAYYDFIKANEAAGFTSTPKGYTWHHVEDGRTLILVPSDLHGTVRHTGGASLIKKGIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLB5</accession>
    <name>A0A386PLB5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argR</name>
        <name evidence="10" type="ORF">CP523_15095</name>
        <name evidence="11" type="ORF">EI377_10050</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676006.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01265"/>
    <dbReference type="EnsemblBacteria" id="AYE35652">
        <property type="protein sequence ID" value="AYE35652"/>
        <property type="gene ID" value="CP523_15095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61039">
        <property type="protein sequence ID" value="QAS61039"/>
        <property type="gene ID" value="EI377_10050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15095"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="9">
        <location>
            <begin position="80"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="16442" checksum="148D2D72F7052EF8" modified="2018-12-05" version="1">MKSKRHNKILEIINGKDIETQEELAEELKMAGFDVTQATVSRDIKILKLIKMQSASGKYRYVASSKEQKDINDKLASILSNAAVSVENVDKFVVVKTLTGSANAVAEAIDTLFDTDVAGTIAGDNTIFILVRNIEKAEELVTRVRKMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLN0</accession>
    <name>A0A386PLN0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05155</name>
        <name evidence="9" type="ORF">EI377_15715</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01820"/>
    <dbReference type="EnsemblBacteria" id="AYE35822">
        <property type="protein sequence ID" value="AYE35822"/>
        <property type="gene ID" value="CP523_05155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62057">
        <property type="protein sequence ID" value="QAS62057"/>
        <property type="gene ID" value="EI377_15715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="129"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="345" mass="39495" checksum="5DE29E92F282F0CA" modified="2018-12-05" version="1">MKILVNKKIKLLFCWILLFIIAFGLLSVVFISLNVKNTALYVLVSSLSMGILILAVVYQYFKEQNKIMENAVTQIKEYISGNENARIECNDEGQLYRLFHEVNSLVSILNAHAENEKKAKKFLKDTISDISHQLKTPLAALNIYNGIIQEESKDLPTIKEFNNLSEQELDRIETLVQNLLKITKLDAGTILIEKNIENVSEMMSSIERHFLYRAEQEEKKLYLSGNDTHTLLCDRNWMIEAISNIVKNAFDHTEKGNTISIEWKQFASIIQITIKDNGYGIYPEDLHHIFKRFYRSRFSKDTQGIGLGLSLTKAIVEAHRGTIEVNSELGIGTVFTMNFLIPTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PME9</accession>
    <name>A0A386PME9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14305</name>
        <name evidence="8" type="ORF">EI377_09215</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE35879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676848.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35879">
        <property type="protein sequence ID" value="AYE35879"/>
        <property type="gene ID" value="CP523_14305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62191">
        <property type="protein sequence ID" value="QAS62191"/>
        <property type="gene ID" value="EI377_09215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="56"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
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        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="298" mass="33985" checksum="0C0B3E028EC17DC0" modified="2018-12-05" version="1">MKILNNCNLCIRNCSIDRNSGKVGFCNSSNKLRVAKAYLHLWEEPCISGKNGSGTVFFSNCNLKCVFCQNHIISNDGLGKEISIERLSEIFLELQEKGAHNINLVTPTHYVPQIIEALNIAKNKGLYLPIIYNTNGIDSLDTIKRLNGYIDVYLPDFKYFNDKYSLKYSKIKGYSKNLLTILEEMFNQVDEPIFNENGIIQKGVIIRHLMLPGLLFDSKKVIDTIYNKFGNKVYISLMNQYTPMYDSIKYPEINKPLNPKHYDSLIDYSIELGVKNGFIQDTGTNSKSFIPDFNNEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">EI377_10785</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 7534</strain>
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32965">
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        <property type="gene ID" value="CP523_00115"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07875">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="83" mass="9653" checksum="DA00A1D10A819554" modified="2018-12-05" version="1">MKEKDIMNDYLSMINSSLTGYASIIAQTDNQELRQTIQQMRNEDEIRQYKVYQTAKEKGYYKPAQPANQTEINTVKSELTANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB47</accession>
    <name>A0A386PB47_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00140</name>
        <name evidence="3" type="ORF">EI377_10760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    <reference evidence="2" key="1">
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677404.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01204"/>
    <dbReference type="EnsemblBacteria" id="AYE32970">
        <property type="protein sequence ID" value="AYE32970"/>
        <property type="gene ID" value="CP523_00140"/>
    </dbReference>
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        <property type="gene ID" value="EI377_10760"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="30513" checksum="15FC1B4FB593C26B" modified="2018-12-05" version="1">MSYSDIYKSIGLNTEISRLRKQAYIGWDKEVKMLKNLGLEDGMRILEVGSGPGFVTELLLREFQNSIVTSLDMDNDLMEIARNRLEGTFKNRLNFVNESILNTSFKDNTFDFVLVRFVYQHINNPLKATKEIYRVLKPGGKVVIVDIDNGIWGVTNPELKLIPYLNNSLARFQNNSGGDRNIGRKLIKILKYSGFKNLDFQIVVKHSDLIGMDKFKDLSSIKNMQNTIFSKNPEISRIISSYNKFYNLESSTIIMLVIMAYGEKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBC9</accession>
    <name>A0A386PBC9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00266 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01530</name>
        <name evidence="2" type="ORF">EI377_12050</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675652.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33233">
        <property type="protein sequence ID" value="AYE33233"/>
        <property type="gene ID" value="CP523_01530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61405">
        <property type="protein sequence ID" value="QAS61405"/>
        <property type="gene ID" value="EI377_12050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="28421" checksum="62B143CD31D531CF" modified="2018-12-05" version="1">MNSHEIDFKLYGDDMQFVEIELDPRETVIAEAGAMMMMDNNISMETIFGDGSNKNNNGGFFGKLGSAAKRVITGESLFLTAFTNLGSSKEKVAFASPYPGKIIPVDLSKYGGKVICQKDAFLCAAKGVSIGIDFKRKLSTGFFGGEGFILQKLEGDGLAFIHAGGTIVKKTLLPGQMLKIDTGCLVAMTKDVNYDIQFVGGVKNTLFGGEGLFFATLTGPGEVWVQSLPFSRLASRVFAAAPVTGTSSKDEGSILGPISNIFESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBD6</accession>
    <name>A0A386PBD6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspD</name>
        <name evidence="4" type="ORF">CP523_01580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00869"/>
    <dbReference type="EnsemblBacteria" id="AYE33243">
        <property type="protein sequence ID" value="AYE33243"/>
        <property type="gene ID" value="CP523_01580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022518">
        <property type="entry name" value="Aspartate_4-decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03801">
        <property type="entry name" value="asp_4_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="198"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="542" mass="62081" checksum="6758D39B64C13826" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBD7</accession>
    <name>A0A386PBD7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Insulinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00635</name>
        <name evidence="6" type="ORF">EI377_11125</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676362.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00658"/>
    <dbReference type="EnsemblBacteria" id="AYE33060">
        <property type="protein sequence ID" value="AYE33060"/>
        <property type="gene ID" value="CP523_00635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61229">
        <property type="protein sequence ID" value="QAS61229"/>
        <property type="gene ID" value="EI377_11125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="3">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="4">
        <location>
            <begin position="165"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="435" mass="49485" checksum="61628757295E59B7" modified="2018-12-05" version="1">MYNLYTLKNGLRVVTEYIEHVNSVSVGVMVQNGSRNENKDVNGISHFIEHMFFKGTEKRISKDIVQEIENVGGQINAYTSKEATCYYIKALNTHLELSIDILSDMILNSKFDEEEIEKEKGVVIEEINMSEDTPEDVLDNNQSEAIFGDNSLSYPILGTIDSVKSFNREKIMKFIHSKYTPYNSVISICGKFDENELKKILEDYFGEWKSDNIYVPEYKNPILLNDSKYTDKQIEQLHINLAFNGLPYAHEKAYSLVLLNNILGGGASSILFQKVREELGLCYTIYSYGQPYLGTGIVNIYTGLSKQYADKALSIISKELERFSKEGITKNILEINKEKIKANYILGLESTSSRMFANAKTVLLQNKINTQEDVIKRINNINNDDINYVLEKCFKPGIISSAYVGQDVDYENLNNFICKDTKAYDNSGQNGKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBM7</accession>
    <name>A0A386PBM7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01105</name>
        <name evidence="4" type="ORF">EI377_11605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674443.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02297"/>
    <dbReference type="EnsemblBacteria" id="AYE33150">
        <property type="protein sequence ID" value="AYE33150"/>
        <property type="gene ID" value="CP523_01105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61320">
        <property type="protein sequence ID" value="QAS61320"/>
        <property type="gene ID" value="EI377_11605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="537" mass="60368" checksum="7778C072373D63D2" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC78</accession>
    <name>A0A386PC78_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03305</name>
        <name evidence="7" type="ORF">EI377_13820</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677222.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02123"/>
    <dbReference type="EnsemblBacteria" id="AYE33563">
        <property type="protein sequence ID" value="AYE33563"/>
        <property type="gene ID" value="CP523_03305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61726">
        <property type="protein sequence ID" value="QAS61726"/>
        <property type="gene ID" value="EI377_13820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="397"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="495" mass="57446" checksum="7FB9528113E65F2F" modified="2018-12-05" version="1">MIKVLIVDDEYYSRKGLKCIIPWEEMKCNVLGEASNAYEAIDLAEKINPDIIVTDINMPEIDGIEMAKRIKKFLPDVKFVVITGYDNFQYARGAVKINALDFILKPIQVGEFTEAITNAVKLIEKERLTTTISTEKQILRILRGQTPIEFVHSYFNNEDSVKIVLINNDSYDYFVNNNKSNINTKISYIIKEWIKINLGKVYIVEPHANRIALIITEEYNLNFKELIKKVIEEVEGVLTISITNVESPLKLEELYKRAKNLYSKCFYEGYGKVFNENKEENIKPNYEKLDDLVNEIVNNILNIDIKKSEKNVNKLFEIFSNNEIKKSKIIKLVFELILRVKQGFQELDISVESLEAIELENDYDQMLYLKKDLETFIVVAIENIREYRGELEDSSIKRAIKFINSNFNKNISLKIVASSVYLNESYLSRELKQTLGMGFSEYIRKLRIEKAMDLLKKGYSISNIAKEVGYSDYRQFSSNFKKYTGDVPSNYKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCJ2</accession>
    <name>A0A386PCJ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gpmI</name>
        <name evidence="14" type="ORF">CP523_03960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675535.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01562"/>
    <dbReference type="EnsemblBacteria" id="AYE33683">
        <property type="protein sequence ID" value="AYE33683"/>
        <property type="gene ID" value="CP523_03960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03960"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="4"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="82"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="260"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="512" mass="56499" checksum="0C2616128C57043C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCL0</accession>
    <name>A0A386PCL0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-3B C(17)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobJ</name>
        <name evidence="6" type="ORF">CP523_01450</name>
        <name evidence="7" type="ORF">EI377_11970</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.131" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675616.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00842"/>
    <dbReference type="EnsemblBacteria" id="AYE33217">
        <property type="protein sequence ID" value="AYE33217"/>
        <property type="gene ID" value="CP523_01450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61389">
        <property type="protein sequence ID" value="QAS61389"/>
        <property type="gene ID" value="EI377_11970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01450"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="238" mass="26227" checksum="1F1E5EEC3A6EAC19" modified="2018-12-05" version="1">MGKLYVIGIGPGGLDHITMKALKAIEESNIIVGYTKYVSMIKPLIGEKEVFQTGMRGEEDRCREALKLSKDNTVALISTGDSGIYGMAGLILELKNDENVEIIPGITASSAAGSVVGAPLMHDNCNISLSDLMTPYEDIKKRVKLAAEGDFVISLYNPRSKGRPHYLKECIEIIKEYRDLNTPIAVIRNALRDEESYNLFKLGEFDETVVDMLSIVIIGNSKSYIKDGKFVTPRGYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCM1</accession>
    <name>A0A386PCM1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spermidine/putrescine ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_03135</name>
        <name evidence="5" type="ORF">EI377_13650</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33530">
        <property type="protein sequence ID" value="AYE33530"/>
        <property type="gene ID" value="CP523_03135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61693">
        <property type="protein sequence ID" value="QAS61693"/>
        <property type="gene ID" value="EI377_13650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019574">
        <property type="entry name" value="Periplasmic_polyamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362742" evidence="3">
        <location>
            <begin position="28"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR019574-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="355" mass="40735" checksum="6C3AC263E1C5B66C" modified="2018-12-05" version="1">MRKTIKITSFMCVFVLMVSLFTGCSSKEKKKTINILNYGENIADGLLKEFEQQYNIKVNEVTFDTMEKMYIELTSGKTKWDAVLVSDYMADRVIQEGLIQKINKNNIPNLKSMNEGDMGRSYDPNNEYTVPYMNGTIGIIYNKDIVTEQVDSWDIMWNPEYKNEIFVLDSPRDAIGMALKKLGYSLNSTNPKELEEAKKLLIEQKELGTIYGADEVQDLMISGERAVAMIWSGEGLNLADEHENLEYVVPKEGANYWLDSWAIPVDANDKEAAEIFINFVSEKDNALKIADQIGYTTPQKQAMEAQPEEVRNNPGAYMPKEVTDKCEVYKYFSQEDLKLYENIWLEVMTHKVDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCP7</accession>
    <name>A0A386PCP7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_04275</name>
        <name evidence="7" type="ORF">EI377_14800</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676488.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00423"/>
    <dbReference type="EnsemblBacteria" id="AYE33743">
        <property type="protein sequence ID" value="AYE33743"/>
        <property type="gene ID" value="CP523_04275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61899">
        <property type="protein sequence ID" value="QAS61899"/>
        <property type="gene ID" value="EI377_14800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="106" mass="12450" checksum="759608CCA6DD7DD1" modified="2018-12-05" version="1">MEFYLGKEVKVIIDRKLGSKHPKHNLIYILNYGYIPNTISGDGEEIDAYIIGGFETLEKFHRYVVGIVKREDDIEDTLVVCKELSKYNKEQIQSLVEFQERFLIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD01</accession>
    <name>A0A386PD01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33204">
        <property type="protein sequence ID" value="AYE33204"/>
        <property type="gene ID" value="CP523_01385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="181" mass="21060" checksum="EB2144A4B28A6AB1" modified="2018-12-05" version="1">MLNKLEKVAKELNKNNIRWAIGASILLKEYGIVNEVNDIDIIVDCKDIGKVDKALKEIGIKRDENKNSNYSTKYFYEYLVDGVDIDVMADFAINYENGVYTVVLDEKSIASYKTLNGIKIPFMALEDWYIIYQLIKGREVKVMLIEKYLMENGIRHRELIDRALKNDLPKDVLKRSKKLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD55</accession>
    <name>A0A386PD55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS ascorbate transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05245</name>
        <name evidence="9" type="ORF">EI377_15805</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676257.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01838"/>
    <dbReference type="EnsemblBacteria" id="AYE33923">
        <property type="protein sequence ID" value="AYE33923"/>
        <property type="gene ID" value="CP523_05245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62074">
        <property type="protein sequence ID" value="QAS62074"/>
        <property type="gene ID" value="EI377_15805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="484" mass="53901" checksum="EB22D725F2C2E054" modified="2018-12-05" version="1">MDFFIKIWEFFQVNILTQPAFFIGFIVLLGYLLLRRPIYEAFAGFVKATVGYLILNVAASGLVNNFRPILAGLKDRFNLTAAVIDPYFGQTAAQSAIEGIGRSFSLMMLVLLVAFLFNLVLVFFRKWTKIRTVFITGHIMVQQSSTALWILLFCFPQLQDTKIVIMLGLLLGTYWSVSANLTVEACQELTEGGGFAIGHQQMFGVWLTDKVAGKFGKNNKKIEDLELPGFLSIFNDNVVATGVLMLLFFGIIMAILGPELLQEIDKSFKPERNFFFYIMEKSFNFAVYLSILQLGVRMFVSELTESFQGISNKLLPGSMPAVDCAAVYGFGHPNAITIGFLFGALGQFIAILGLIVFKSPVLIITGFVPVFFDNATFAVFANRKGGLKAAITIPFVAGMIQVLGGAFSAHFFQLSQYGGWHGNFDWDTLWPLFGVVMKYGQYFGVAAVIIFMLAIPQIQYRKNKENYFKIAEDYESVVNGETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD96</accession>
    <name>A0A386PD96_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05495</name>
        <name evidence="2" type="ORF">EI377_00115</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33965">
        <property type="protein sequence ID" value="AYE33965"/>
        <property type="gene ID" value="CP523_05495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59356">
        <property type="protein sequence ID" value="QAS59356"/>
        <property type="gene ID" value="EI377_00115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="111" mass="13033" checksum="3727727BEF34762D" modified="2018-12-05" version="1">MINYYELKYLVTETFYENILQEKYTIGQSAGRCFVEFYNEITLNNIESLIVYSTVLARIAKHEKNVLDSFKKEVKSMNDLANEKDIFNVVKTDEVEALKEDVDYINSKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDB0</accession>
    <name>A0A386PDB0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycyl-radical enzyme activating protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Pyruvate formate lyase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_00255</name>
        <name evidence="13" type="ORF">EI377_10630</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01181"/>
    <dbReference type="EnsemblBacteria" id="AYE32991">
        <property type="protein sequence ID" value="AYE32991"/>
        <property type="gene ID" value="CP523_00255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61141">
        <property type="protein sequence ID" value="QAS61141"/>
        <property type="gene ID" value="EI377_10630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE32991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="306" mass="34398" checksum="03E21AEA0035117C" modified="2018-12-05" version="1">MTCEKGIIFNIQRFSIHDGPGIRTVVFLKGCPLHCPWCSNPESQNNNIQITWDKNKCINCEKCIDICPTKSLSNIIKDGNKIISVNEKTCVGCLKCKNECPQSAISYEGEFKDVDEIINEVMKDDVFYDESGGGVTISGGEVLQQAEFAMQLLKKAHENGLHTASETTCYTDFETFKRFIENLDLLLCDIKHYDSNKHRDVVGVSLENIQKNIKYAIDCGLDVIGRIPIIPGFNFSIKDAIGLSDALINLGINKVNLLPFHQFGENKYTLLNKTYNMSDVDALKKDDPKFLEFVSIFKEKGLDVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDB9</accession>
    <name>A0A386PDB9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Formate acetyltransferase</fullName>
            <ecNumber evidence="5 14">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pflB</name>
        <name evidence="17" type="ORF">CP523_02030</name>
        <name evidence="18" type="ORF">EI377_12550</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5 14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678881.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00126"/>
    <dbReference type="EnsemblBacteria" id="AYE33324">
        <property type="protein sequence ID" value="AYE33324"/>
        <property type="gene ID" value="CP523_02030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61494">
        <property type="protein sequence ID" value="QAS61494"/>
        <property type="gene ID" value="EI377_12550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02030"/>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0556">Organic radical</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="16">
        <location>
            <begin position="1"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="15">
        <location>
            <begin position="618"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="13">
        <location>
            <position position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS61494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="742" mass="82598" checksum="DEE9DA6DBF45C9DB" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDE3</accession>
    <name>A0A386PDE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe(3+) ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00430</name>
        <name evidence="4" type="ORF">EI377_10920</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00597"/>
    <dbReference type="EnsemblBacteria" id="AYE33021">
        <property type="protein sequence ID" value="AYE33021"/>
        <property type="gene ID" value="CP523_00430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61190">
        <property type="protein sequence ID" value="QAS61190"/>
        <property type="gene ID" value="EI377_10920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR002825-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="37823" checksum="5678741A68F3AB1B" modified="2018-12-05" version="1">MIGVISLGILAGCGKEELSDKSNSGVLNLYTSRHYDTDDALYEEFTKETGVKINVVKGEPDALLERLEREGKDTEADLLITADAGRLYAAKEKKLLQPVESKVVDENIPSNLRDKDNEWFGLAVRARVLVYSKERVNPEELSTYEELIDSKWSGKILTRSSTNIYNQSLVASMIAINGEEATEKWAKELVKNFARDPKGSDRDQAKAVAAGEGDIAIMNTYYVGKLIDSKDSEEVKVGEKVGVFFPNQNTTGTHVNVSAIGLTKYSKNKENAIKFIEFLTSEKAQKQFAETNFEYPANPKVESAELLKSWGEFKPQDINLSALGEYNAKAVEIMNKVGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDK5</accession>
    <name>A0A386PDK5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_06170</name>
        <name evidence="9" type="ORF">EI377_00650</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675153.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01935"/>
    <dbReference type="EnsemblBacteria" id="AYE34085">
        <property type="protein sequence ID" value="AYE34085"/>
        <property type="gene ID" value="CP523_06170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59455">
        <property type="protein sequence ID" value="QAS59455"/>
        <property type="gene ID" value="EI377_00650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="27014" checksum="281937BA5564BF47" modified="2018-12-05" version="1">MYSIAICEDNSIQLDSLNNILKKFSIDENIKINIDMFSTGEDLLEHGFNSYDIIILDIKMGNLTGIEVAKIIREVNKSIKIIFLTALESHWSDGYTVNAFRYILKPLNADSFYNEIKELINELNKSKIFIPIDSNGTIKKISISDILYLEILDRKVLIHTNSDIYTSTNKLKYWNDMLSPLGFSNPHNSFLVNLNYVKELNKNNVVLCNGDTIYASQRKFKSFKKDFMNFLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDU9</accession>
    <name>A0A386PDU9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01315</name>
        <name evidence="4" type="ORF">EI377_11815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675564.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00814"/>
    <dbReference type="EnsemblBacteria" id="AYE33191">
        <property type="protein sequence ID" value="AYE33191"/>
        <property type="gene ID" value="CP523_01315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61361">
        <property type="protein sequence ID" value="QAS61361"/>
        <property type="gene ID" value="EI377_11815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="36752" checksum="E6F93A0165C1A60D" modified="2018-12-05" version="1">MVNEKHLFNNYINIARNFVSEKNYFKALKFYNKAYKFDEGKKDIELILDMALLYDKILRKDLAEEKYKEVLELDKNEARAYYGLGVLYDEECLYDKAIEYYNKAIEKDENYDRAYFFVANAYDEIGEKNKAIENYRKVLKLIPNDLWANANLACIYDELENLDYALKYMNKALEISPNHFRILFNMGVFTKKVGDIEKSIEYYEKSIKENPKYPYSFLNLAIIYRENNNFNKAIEVISRGIEENNEEGFLYYNRACFYSNIGRIQDSLEDLIKSTELNDFFYEYMKNDIELDNIRHLTLYKTKFDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE03</accession>
    <name>A0A386PE03_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_07145</name>
        <name evidence="12" type="ORF">EI377_01890</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673714.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01044"/>
    <dbReference type="EnsemblBacteria" id="AYE34243">
        <property type="protein sequence ID" value="AYE34243"/>
        <property type="gene ID" value="CP523_07145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59648">
        <property type="protein sequence ID" value="QAS59648"/>
        <property type="gene ID" value="EI377_01890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="216"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="525" mass="58666" checksum="6DC932463EB804D9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB8</accession>
    <name>A0A386PEB8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1858 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01405</name>
        <name evidence="3" type="ORF">EI377_11920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675593.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33208">
        <property type="protein sequence ID" value="AYE33208"/>
        <property type="gene ID" value="CP523_01405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61380">
        <property type="protein sequence ID" value="QAS61380"/>
        <property type="gene ID" value="EI377_11920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="6539" checksum="8CBAE3ADD7B2D59E" modified="2018-12-05" version="1">MITKDMTIGEVIRVNEKAVDVFMRFGMGCVGCPSAQAETIEEAVSIHGLNLDELLEALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEE3</accession>
    <name>A0A386PEE3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">thiI</name>
        <name evidence="9" type="ORF">CP523_02455</name>
        <name evidence="10" type="ORF">EI377_12985</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673958.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00476"/>
    <dbReference type="EnsemblBacteria" id="AYE33401">
        <property type="protein sequence ID" value="AYE33401"/>
        <property type="gene ID" value="CP523_02455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61575">
        <property type="protein sequence ID" value="QAS61575"/>
        <property type="gene ID" value="EI377_12985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02455"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="384" mass="43686" checksum="C522B6F678F774C6" modified="2018-12-05" version="1">MNRLILVKYASEIFLKGLNRNKFEKKLRDNIKKKLKGLEYEIIIDQGRYFIKSDNIEEAVERVRKVFGISEVCIVTETKRDMQAIKEEALKKVREANPKTFKIETNRANKVFPKTSLETSKEVGGYVVHHIDGIEVNVKKPECLVNIEIREKAYIYTTNDKVKGVGGLPYGINGSTMLMLSGGIDSPVAGYLMARRGVELNCVYYHSHPYTSERAKDKVKNLAKILTTYTEKVNLYIVPFTEIQMSIINGCKEDELTIIMRRFMMRVACTIAEEKGIQSVSSGESIGQVASQTMEGLMVSNDCADRPVFRPLIAMDKTDIMDIAREIGTYETSILPYEDCCTIFVPKHPKTKPRVDLIRKSEESLDIDRLVKEAIENTELVIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEE7</accession>
    <name>A0A386PEE7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enolase</fullName>
            <ecNumber evidence="9">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">eno</name>
        <name evidence="14" type="ORF">CP523_03650</name>
        <name evidence="15" type="ORF">EI377_14180</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
        <text evidence="9">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677717.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02215"/>
    <dbReference type="EnsemblBacteria" id="AYE33624">
        <property type="protein sequence ID" value="AYE33624"/>
        <property type="gene ID" value="CP523_03650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61788">
        <property type="protein sequence ID" value="QAS61788"/>
        <property type="gene ID" value="EI377_14180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03650"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="13">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="12">
        <location>
            <begin position="142"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="367"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="430" mass="46863" checksum="187D5B7170AE3250" modified="2018-12-05" version="1">MKKDLKIVNVIGRQILDSRCFPTVEVEVYLEDGTVGRAAVPSGASTGIYEAVELRDGNKDLFQGKSVLNAVANVNDIIAKNLKGINVYNQPYIDKLLIDLDGTENKGKLGANAILGVSLACAKAAAESLSLPLYQYIGGANAKVLPVPMMNILNGGSHADNSVDLQEFMIMPAGAETFSLALEMCANVYHTLKKILLEKGYSTAIGDEGGFAPNLKSNEEALEVIIEAIEKAGYKAGEDMFIAIDAASSEYYKDGKYVLEHEGKSLNAEEMVSFFEEWVNKYPIISIEDGMAEEDWEGWKLLTERLGKKVQLVGDDLFVTNTERLSMGIEKGVANSILIKLNQIGTLTETLNSIEMANRAGYTAVVSHRSGETEDTTIADLVVAVNAGQIKTGAPARSERVAKYNQLLRIESELGEIAEYRKKKAFFNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEF7</accession>
    <name>A0A386PEF7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03700</name>
        <name evidence="3" type="ORF">EI377_14230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677693.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33634">
        <property type="protein sequence ID" value="AYE33634"/>
        <property type="gene ID" value="CP523_03700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61798">
        <property type="protein sequence ID" value="QAS61798"/>
        <property type="gene ID" value="EI377_14230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033787957" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="125" mass="13026" checksum="2E91D78EF5D5D3D2" modified="2018-12-05" version="1">MNKKVKSIAVMLGLFLSIGVVANASVGVPVEGQSGAGTRYSGYVQGSKNIFACWVATNTSRKSGYEDVYAYVEVVNSQGYVIGAGAENTGADYAYSGTVTRNGGKNAYGSVGTANETSRTFAHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEG0</accession>
    <name>A0A386PEG0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="5">2.7.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfkB</name>
        <name evidence="7" type="ORF">CP523_00560</name>
        <name evidence="8" type="ORF">EI377_11050</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:58695"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.144"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-fructose 1-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14213"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.56"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the carbohydrate kinase PfkB family. LacC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676337.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00642"/>
    <dbReference type="EnsemblBacteria" id="AYE33046">
        <property type="protein sequence ID" value="AYE33046"/>
        <property type="gene ID" value="CP523_00560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61215">
        <property type="protein sequence ID" value="QAS61215"/>
        <property type="gene ID" value="EI377_11050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00560"/>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005988">
        <property type="term" value="P:lactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="6">
        <location>
            <begin position="11"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="305" mass="33123" checksum="D8CF37CB574B3F2A" modified="2018-12-05" version="1">MIYTLTLNPSIDYIIEVDSLNLGLVNRTTKEVKFPGGKGINVSRVLSNLNIENKALGFLGGLTGKFIESSLKNLNVNCDFINVVEDSRINVKIKGIEETEINASGPKISNENFKELMTKLANLDENDILVLAGSVQNSLPNDIYMQIQTMLKNKNVKIIVDTSGPALLEAVKQKPFLIKPNNHEIEEIFNVTINCEKDLIKYGSELVKLGAENVIISMAGDGALLICNEGIFKGNAPKGVVKNSVGAGDSLVGGFLAEYSISNDIVKSFKMGIASGSASAFSMDLCTKDEVYDLLPKINITKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW4</accession>
    <name>A0A386PEW4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05575</name>
        <name evidence="2" type="ORF">EI377_16085</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33977">
        <property type="protein sequence ID" value="AYE33977"/>
        <property type="gene ID" value="CP523_05575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62119">
        <property type="protein sequence ID" value="QAS62119"/>
        <property type="gene ID" value="EI377_16085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="115" mass="13821" checksum="463228423B5D3628" modified="2018-12-05" version="1">MNIDFFELKYLITDSFYSEILKNKYSFEQSAGICYEAFDEYINSEAIESIISISEIIRLKIRHQVELTQYDIDNIKKVLILFKAMNVEKILNTSEYEYLEEDIQTIEYQYNKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX2</accession>
    <name>A0A386PEX2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalt-precorrin-6A reductase</fullName>
            <ecNumber evidence="5">1.3.1.106</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Precorrin-6A reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_01445</name>
        <name evidence="5" type="ORF">EI377_11965</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.106" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675613.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00841"/>
    <dbReference type="EnsemblBacteria" id="AYE33216">
        <property type="protein sequence ID" value="AYE33216"/>
        <property type="gene ID" value="CP523_01445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61388">
        <property type="protein sequence ID" value="QAS61388"/>
        <property type="gene ID" value="EI377_11965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01445"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="256" mass="28925" checksum="C02671DD5ADDE373" modified="2018-12-05" version="1">MIAFILGTSEGREILSLINEYTDKIVVSTATKYGGELLKNFKILHINDKPLNEEEFKELFKKFNIKVLVDASHPYAQEVSKTSIKICKYMNIDYIRYEREGYFNKVSEDKNIIKINGYEDLKEALKNIEGNVLNTTGSNNVGNIMKLNLKNRVIHRILPSVQVLQKLIDSGVDIGDIIAIKGPFGYEINSGIIKEFKIKALITKDSGIEGGIKEKVEACINNGAKIIVINKPKINYGQAFNNVHRMIDAIVKKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF10</accession>
    <name>A0A386PF10_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4325 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08100</name>
        <name evidence="3" type="ORF">EI377_02855</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34390">
        <property type="protein sequence ID" value="AYE34390"/>
        <property type="gene ID" value="CP523_08100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59795">
        <property type="protein sequence ID" value="QAS59795"/>
        <property type="gene ID" value="EI377_02855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025474">
        <property type="entry name" value="DUF4325"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14213">
        <property type="entry name" value="DUF4325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4325" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="10353" checksum="63248FC3DF4E57FB" modified="2018-12-05" version="1">MNIKVRDILGENIYIEDAILLREIIRNNINEGILLDFDGFERVPSTFLNCLLSDLIYKFGREFIFKQIGVKNLSNYSDYSRVVLGTTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF11</accession>
    <name>A0A386PF11_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09535</name>
        <name evidence="3" type="ORF">EI377_04280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676666.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02613"/>
    <dbReference type="EnsemblBacteria" id="AYE34645">
        <property type="protein sequence ID" value="AYE34645"/>
        <property type="gene ID" value="CP523_09535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60044">
        <property type="protein sequence ID" value="QAS60044"/>
        <property type="gene ID" value="EI377_04280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="197" mass="23443" checksum="4A77B66B46F08A0C" modified="2018-12-05" version="1">MLMNTHKMLANNFIENIDEDKIFLIKESHFVWGNIKPDCASKYKLKKHYFDESFDMIVKKIEFLSSLTVNDIYTKYSINKFNQELGVICHFLCDYFCVPHNQRWEFKNPNAMKDHIIYEKDLAKVAKEFKIKKDINSHLTSEEITIYILSLQNEYEGKIDFNHDLTFAYYVCDSIINMILGEVLLNEKIKEHFSMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF13</accession>
    <name>A0A386PF13_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">thrS</name>
        <name evidence="13" type="ORF">CP523_09455</name>
        <name evidence="14" type="ORF">EI377_04200</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679247.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00746"/>
    <dbReference type="EnsemblBacteria" id="AYE34633">
        <property type="protein sequence ID" value="AYE34633"/>
        <property type="gene ID" value="CP523_09455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60032">
        <property type="protein sequence ID" value="QAS60032"/>
        <property type="gene ID" value="EI377_04200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="268"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="645" mass="73318" checksum="E5D6E3F53246D0A6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF38</accession>
    <name>A0A386PF38_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02910</name>
        <name evidence="2" type="ORF">EI377_13435</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677016.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33488">
        <property type="protein sequence ID" value="AYE33488"/>
        <property type="gene ID" value="CP523_02910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61659">
        <property type="protein sequence ID" value="QAS61659"/>
        <property type="gene ID" value="EI377_13435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="235" mass="26519" checksum="9C788E716F89A3DC" modified="2018-12-05" version="1">MNYNNNNIIEVDDDLKFVPLNIREPFSCKDSKWIPFINFDVDPDRNITNNFLFGFGSPIDNNSINSGIVNIPQIPVMSPNTTNIPQNTLEPSLNPSIIPTLPQNNTTNPNNNEGAINLLYPSEVPSDELYSYNKTGSCKANRVVDIPSTLSENLNSKFNEDLTHMNILKDFDFSMDDSSDLRSSNCSNIDKIFKEIEDNHSGILGTFKAYRMPYPISSLIVKKVIKLSLEYSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF74</accession>
    <name>A0A386PF74_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">CP523_01990</name>
        <name evidence="14" type="ORF">EI377_12510</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678254.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01150"/>
    <dbReference type="EnsemblBacteria" id="AYE33316">
        <property type="protein sequence ID" value="AYE33316"/>
        <property type="gene ID" value="CP523_01990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61486">
        <property type="protein sequence ID" value="QAS61486"/>
        <property type="gene ID" value="EI377_12510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="448"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="563" mass="64227" checksum="148FE4959953BDDB" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF80</accession>
    <name>A0A386PF80_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase U32</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">U32 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01115</name>
        <name evidence="3" type="ORF">EI377_11615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674438.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02295"/>
    <dbReference type="EnsemblBacteria" id="AYE33152">
        <property type="protein sequence ID" value="AYE33152"/>
        <property type="gene ID" value="CP523_01115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61322">
        <property type="protein sequence ID" value="QAS61322"/>
        <property type="gene ID" value="EI377_11615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="320"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="411" mass="46887" checksum="536488C96B94BD29" modified="2018-12-05" version="1">MNKPEILAPAGSLEKLKIAVDFGADAVYIGGGKLNLRAFSDNFTNEEIAEGVKYCHERGRKLYVTMNVFPRNHDLTGVENYIRGLNDLGIDAIIVADPSIIIAAKEVAPNLEIHLSTQANTVNWKATKFWYDQGVKRVVLARELTFNEINGIKANIPEECELEVFVHGSMCIAYSGRCLISNYMLGRDANKGICSNACRYKYHLVEETRPGQYYPVVEDDNGTYIMNSKDLCMIHHIPELVKSGVHSLKIEGRMKSEFYVASVVKAYRDAVDSYMENPDRYEFKDEWMETLLKISHRPYHTGFFFGKSGEQNYEESSYVRDYDIVGIVKSYDPETKVATILQKNRVFEDDTVEVLRAYTPYFNIQLKEMFDVEKNVKTNVANRAHMVFTVKVDEPLKENDMLVKGKKALNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE4</accession>
    <name>A0A386PFE4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-xylose ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03510</name>
        <name evidence="6" type="ORF">EI377_14035</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02253"/>
    <dbReference type="EnsemblBacteria" id="AYE33598">
        <property type="protein sequence ID" value="AYE33598"/>
        <property type="gene ID" value="CP523_03510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61762">
        <property type="protein sequence ID" value="QAS61762"/>
        <property type="gene ID" value="EI377_14035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="255"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="500" mass="55813" checksum="4EA12BAEDEDAB9B9" modified="2018-12-05" version="1">MSAKNPMLKMVNVSKSFPGVKALDNVNVTAFGGEVTALMGENGAGKSTLMKILSGVYQKDQGQVFVEGKEVKIKGIKDAERHGITIIHQELSVIPNLTIAENIFLGNEKYNRFTGKINKSLLIERSKMFLEQIGCNLDPNMLVEDINVGERQMIEIAKALTKNAKIIIMDEPTTALTDVETKKLFEVIDNLKKKGIAIIYISHRMEEIFTICDRVEVLRDGKYAGEAKIADIDNDKLIAMMVGRKIEDQFPYRKIKLGSTILRVNDLNYKDIVKNASLEVKAGEILGVAGLMGSGRTELVKTIFGEYRKTSGEIFLEGNKVNIKCSKDAIENGICYLSEDRKKEGCILGMSVADNMTLCNLRKYERKNKSINRKEEQRDVEEYIKKINIKTPNSEQLIKNLSGGNQQKVILAKWLLLSPKVLIIDEPTRGIDVGAKKEIYELLNELKSMGKAIIMISSDLPEVLGISDRIMVMSEGKISGEISREEATQEKIMKLAVGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH3</accession>
    <name>A0A386PFH3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33994">
        <property type="protein sequence ID" value="AYE33994"/>
        <property type="gene ID" value="CP523_05690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="109"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="291" mass="33285" checksum="262159970A4D5B9E" modified="2018-12-05" version="1">MKEIVENFKVSLIEDGKSPKTIESYIGDIKAFIEFLGSKGVEFNGTLQRFYVVSYKNFLVESNYEVATINKKINSIHALNRYLVATGAMKEIVVENSKDRVKIAYGSEKQVEVYSDKEVDRILFYIQNESKVSKRNKVIVMLLLYTGVRVSELCSIKIKDIDFLNYSIKIYGKGGKFREVPLKFELADAIKEYIKDRDYNVKDSEYLIIGQRGALRRDAINTMLEKLTNEIGMVNKLKPHTFRHTFCTRLINRGVPISTVSKLAGHSSVDTTATFYINSSREEKLKAVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK5</accession>
    <name>A0A386PFK5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Butanol dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03830</name>
        <name evidence="4" type="ORF">EI377_14365</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675486.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01538"/>
    <dbReference type="EnsemblBacteria" id="AYE33658">
        <property type="protein sequence ID" value="AYE33658"/>
        <property type="gene ID" value="CP523_03830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61820">
        <property type="protein sequence ID" value="QAS61820"/>
        <property type="gene ID" value="EI377_14365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd08179">
        <property type="entry name" value="NADPH_BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034802">
        <property type="entry name" value="NADPH_BDH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="388" mass="42985" checksum="F1F504247503D80D" modified="2018-12-05" version="1">MARFTLPRDLYHGAGSLETLKTLKGKRAFVVVGGGSMKRFGFLQKVEDYLKEAGMEVKLFEGVEPDPSVETVMKGAEEMRDFKPDWIVAMGGGSPIDAAKAMWIFYEYPDFTFEQAVVPFGLPELRQKAKFVAIPSTSGTATEVTAFSVITDYKAKIKYPLADFNITPDIAIVDPDLAQTMPAKLVAHTGMDALTHAIEAYTASLRSNFSDPLAMKAIEMVRENLVKSYEGDKEARNLMHEAQCLAGMSFSNALLGIVHSMAHKVGAVFHIPHGCANAIFLPFVIQYNRVECEERYADIAKMLKLEGNTNAELTDSLIKLINEFNTALNIPHTMKEYGVTEEDFKNNVKFIAHNAVLDACTGSSPRAIDDETMEKLLTCTYYGNRVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM3</accession>
    <name>A0A386PFM3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03935</name>
        <name evidence="9" type="ORF">EI377_14460</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675522.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01557"/>
    <dbReference type="EnsemblBacteria" id="AYE33678">
        <property type="protein sequence ID" value="AYE33678"/>
        <property type="gene ID" value="CP523_03935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61835">
        <property type="protein sequence ID" value="QAS61835"/>
        <property type="gene ID" value="EI377_14460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004700">
        <property type="entry name" value="PTS_IIC_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03609">
        <property type="entry name" value="EII-Sor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51106">
        <property type="entry name" value="PTS_EIIC_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="265" mass="27986" checksum="7ADEE25EE5E3082B" modified="2018-12-05" version="1">MEITLLQCILIGLWTAFCLSGMLLGIYSNRCIILSFGVGIILGDIPTALAMGAVSEIAFMGFGVGAGGTVPPNPMGPGIIGTLMAITMKGQGMDPATALALSFPFAVAFQFLITATYTVVSGSSEFAKKSIQKGHFTQFRIAANSTVWVLALVGFIIGFAGAYSVDGLKAVVEMIPAWLITGLSVAGKMLPAIGFAMILSVMAKIELIPFVLLGYVCVAYLNLPVIGIAFVGTTFALLEYFRKNNKNNSNNESVEEEEVVFEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ0</accession>
    <name>A0A386PFQ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02955</name>
        <name evidence="3" type="ORF">EI377_13470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33496">
        <property type="protein sequence ID" value="AYE33496"/>
        <property type="gene ID" value="CP523_02955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61665">
        <property type="protein sequence ID" value="QAS61665"/>
        <property type="gene ID" value="EI377_13470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="240" mass="27018" checksum="82430F98C63467C3" modified="2018-12-05" version="1">MKIMIDDEFSTNENGEVQFNNNSKVKNQGNPNGGVSINGNENYNVFLEVREEGECDSAPENNNYANSNNIHQDYGNGINESYSNNTGDYCCNRNAANGHNFTNTDNAGQEYFNKLNNLDRNLDNNLNNSCAEELNQEKGHIIVCVKLGSKDGVELKSAKVNLYMLNGVSPRLCESKLTDSEGKVIFDNLDDGCYRVISIVDRRYFEKPCYINWNEVIIDSNVKEATVCVVNRIKACCYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ7</accession>
    <name>A0A386PFQ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04085</name>
        <name evidence="3" type="ORF">EI377_14605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02768"/>
    <dbReference type="EnsemblBacteria" id="AYE33708">
        <property type="protein sequence ID" value="AYE33708"/>
        <property type="gene ID" value="CP523_04085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61863">
        <property type="protein sequence ID" value="QAS61863"/>
        <property type="gene ID" value="EI377_14605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="24315" checksum="88FC139EA46DA69F" modified="2018-12-05" version="1">MIGFSYLCVLLFITILILYLIKKNIKSSPKKIKLFVTISLIPLVLRYLVLILGVVIEKHSVIYLLRHIIFLNYFSIPLIILAALFIFLRDEKIRFNVNFIFLAMLLVGYVLMIFSNKISVSINNAFGFVLILEQYLVPTLIYLIILASLSVFSLLYVDKPYSNKLGMKLLLLSLVICIVEFILFLGGIKLFPYPIIGELLVLISLSKGLSTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU5</accession>
    <name>A0A386PFU5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic-di-AMP phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_07550</name>
        <name evidence="6" type="ORF">EI377_02240</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-&gt;5')-adenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="ChEBI" id="CHEBI:138171"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GdpP/PdeA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673817.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01119"/>
    <dbReference type="EnsemblBacteria" id="AYE34307">
        <property type="protein sequence ID" value="AYE34307"/>
        <property type="gene ID" value="CP523_07550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59701">
        <property type="protein sequence ID" value="QAS59701"/>
        <property type="gene ID" value="EI377_02240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014528">
        <property type="entry name" value="GdpP/PdeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026583">
        <property type="entry name" value="YybT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="172"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR026583-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="648" mass="72366" checksum="8054D39CD23756D6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV4</accession>
    <name>A0A386PFV4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02510</name>
        <name evidence="9" type="ORF">EI377_13045</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673946.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00465"/>
    <dbReference type="EnsemblBacteria" id="AYE33412">
        <property type="protein sequence ID" value="AYE33412"/>
        <property type="gene ID" value="CP523_02510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61586">
        <property type="protein sequence ID" value="QAS61586"/>
        <property type="gene ID" value="EI377_13045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="241" mass="27665" checksum="FA00A3E34BA42B16" modified="2018-12-05" version="1">MENQSALGDKGKIIENYIPLVKHLASRVMLGKTKYIEYEDLVSYGIVGLMDAINKYDATKGMKFSSYATIRIRGAMIDEIRKNRPISKGAMDKLAKYNESVERLQNKFMREPTLEEIAIDLNVTKEDISEIENYINYMSVVSLENIIYSDDDEVTIMGIIEDKNSPSPEETLEDKEKVEILAECINKLKEKDKIVLTLYYYEGLTLKEIGSVLQVSESRVCQLHSRAIRNLRALMKKIDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW8</accession>
    <name>A0A386PFW8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34337">
        <property type="protein sequence ID" value="AYE34337"/>
        <property type="gene ID" value="CP523_07755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="104" mass="12076" checksum="4AD99AA08A689D73" modified="2018-12-05" version="1">MKIGLEESKKLYPNELSGGMKQKINIARALISKSKFLIMDEPFKSIDIKSKIKIINIIKEKIRKEKLTVIFVSHDKEEIDLLGEKIFILDGQPIKIIEEYDNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX5</accession>
    <name>A0A386PFX5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal transduction histidine-protein kinase ArlS</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_09905</name>
        <name evidence="12" type="ORF">EI377_04690</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676526.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00310"/>
    <dbReference type="EnsemblBacteria" id="AYE34690">
        <property type="protein sequence ID" value="AYE34690"/>
        <property type="gene ID" value="CP523_09905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60091">
        <property type="protein sequence ID" value="QAS60091"/>
        <property type="gene ID" value="EI377_04690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041610">
        <property type="entry name" value="ArlS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18719">
        <property type="entry name" value="ArlS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="253"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="468" mass="52730" checksum="ACF3EB5461B2E456" modified="2018-12-05" version="1">MESLKSKSIKIRLIRNFFIVIFSIIVFLNVLLLIFVRKYYYDNTEELLRNQIKVSTNFYNKYFSAASLVDVISDNVDAFWNQSNAQVEILDNKGKLLMDSIGVKDEELLKTPDIEKAINGHISRWIGNVDYYKNKIMVVSAPITSNGSVVGVIRLITSMEAVDGTIEVIVGFFLIISILVLVIGVILSILISNSIIEPINSLTLIAEKMASGDMAIRSKVKDEDEVGKLANTLNYMADELEKREQLKNEFISSVSHELRTPLTAIKGWAITLNDESTDKETLKVGFDIIEKETERLTSMVEELLDFSRLINDNISLKKANVDLDTFIIYIKNYMSPRANREGLNFKVNKLNNLGRVYIDGNRLKQILINLLDNSFKFTESGGKVSLTVSNESEYIKFIIEDNGIGISKEDLPRVKEKFFKGKTSKSQNGIGLSICDEIIKLHNGKFNINSTLGIGTVVEVIIPIEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX8</accession>
    <name>A0A386PFX8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fliF</name>
        <name evidence="14" type="ORF">CP523_02615</name>
        <name evidence="15" type="ORF">EI377_13150</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673908.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00444"/>
    <dbReference type="EnsemblBacteria" id="AYE33432">
        <property type="protein sequence ID" value="AYE33432"/>
        <property type="gene ID" value="CP523_02615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61606">
        <property type="protein sequence ID" value="QAS61606"/>
        <property type="gene ID" value="EI377_13150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="45"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="254"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="288"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="522" mass="58287" checksum="7C68DAEF918E9589" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG87</accession>
    <name>A0A386PG87_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="6">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asnS</name>
        <name evidence="8" type="ORF">CP523_08450</name>
        <name evidence="9" type="ORF">EI377_03195</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674816.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01631"/>
    <dbReference type="EnsemblBacteria" id="AYE34457">
        <property type="protein sequence ID" value="AYE34457"/>
        <property type="gene ID" value="CP523_08450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59860">
        <property type="protein sequence ID" value="QAS59860"/>
        <property type="gene ID" value="EI377_03195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="136"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="464" mass="53384" checksum="56E4F913E09520D2" modified="2018-12-05" version="1">MDKVVLIKSLYRNESEYLSKEVKISGWIRTLRASNAFGFIEVNDGTFFKNVQIVFDNKLENFKEVSKLPISSSISVVGTLVATPEAKQPFEIQAKEIVIEGMSQSDYPLQKKRHTFEYLRTIAHLRPRSNAFSAVFRVRSVAAYAIHKFFQERGFVYTHTPILTGSDCEGAGEMFRVTTLDLNNTPKTEDGAIDFSQDFFGKESNLTVSGQLNAECYALAFRNVYTFGPTFRAENSNTARHAAEFWMIEPEISFADLKDDMELAEDMLKYVIEYVMTECPEEMAFFNQFVDKGVIDRLNHVVSSDFGKVTYTEAIEILKKSNKKFDYPVEWGIDLQTEHERYLTEEHFKKPLFVTDYPKDIKAFYMRLNDDQKTVAAMDLLVPGIGEIIGGSQREERIDILTKRMAELGLKEEDYWWYLDLRKFGETKHAGFGLGFERLIMYVTGMSNIRDVIPFPRTTGQSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB4</accession>
    <name>A0A386PGB4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05220</name>
        <name evidence="4" type="ORF">EI377_15780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676243.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01833"/>
    <dbReference type="EnsemblBacteria" id="AYE33918">
        <property type="protein sequence ID" value="AYE33918"/>
        <property type="gene ID" value="CP523_05220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62069">
        <property type="protein sequence ID" value="QAS62069"/>
        <property type="gene ID" value="EI377_15780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="29209" checksum="FCAFADAD301D531E" modified="2018-12-05" version="1">MNKELLINKSKDVRKNIIEMIYEAKSGHPGGSLSCADIITYLYYEKMNVDVNNPKAENRDRFVLSKGHAAPALYSVLAEKGFFPKEELKHLRKMGALLQGHPDSKHVPGVDVSTGSLGQGISNAVGMALGLKTQKSDAKVYTVLGDGELQEGLVWEASMAAAHYKLDNLVAVVDFNGLQIDGKNEDVMTIAPVDEKFKSFGWNVIICDGNDFEDIDRAFNSLAEGKPNLILASTVKGKGVSFMENQAGWHGQAPTEEQKDQALAEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB6</accession>
    <name>A0A386PGB6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06045</name>
        <name evidence="2" type="ORF">EI377_00525</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675093.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34061">
        <property type="protein sequence ID" value="AYE34061"/>
        <property type="gene ID" value="CP523_06045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59432">
        <property type="protein sequence ID" value="QAS59432"/>
        <property type="gene ID" value="EI377_00525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="360" mass="40795" checksum="2349EC4DA5DCA4C3" modified="2018-12-05" version="1">MSNLKERHLFPGANTSRGFYSCFDYIINKETANRVFCIKGGPGTGKSHLMKEIGKYFQNKGYTIEYHHCSSDDASLDAVVIKDLKIALMDGTAPHIVDPVYPIAIDEVLNMGDAMNQDIISKNKQEIIELSKIISSKFKRAYSFFAAAKSIHEDWCKLNAEAMDSYKIDTITESLKEEIFINQKTGYGDERHIFGTSFTPNGIITFVKDLSSEFNNKFVLKGGPGFGKSHILKAIGKTAQKKGYFVEYLHDPFIPDRIEHVFIPELSTCILTENEISQTAFSGKVYNIEDFCKANVLAKNKSDIEYDSKVFYDLIKKGLSYLTEAHALHDDLEKFYIDAIDFDVCNTIYDNVISKIEKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE6</accession>
    <name>A0A386PGE6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatininase</fullName>
            <ecNumber evidence="6">3.5.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10785</name>
        <name evidence="6" type="ORF">EI377_05570</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.10" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674091.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01345"/>
    <dbReference type="EnsemblBacteria" id="AYE34850">
        <property type="protein sequence ID" value="AYE34850"/>
        <property type="gene ID" value="CP523_10785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60244">
        <property type="protein sequence ID" value="QAS60244"/>
        <property type="gene ID" value="EI377_05570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047789">
        <property type="term" value="F:creatininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006602">
        <property type="term" value="P:creatinine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031034">
        <property type="entry name" value="Creatininase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04448">
        <property type="entry name" value="creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="27865" checksum="38BC7B113EFDB6FB" modified="2018-12-05" version="1">MYENVKMTNMTWQEFAKKKDDVIILPIGSTEQHGPHLPTCVDTVLAEGFAYRIAEKVNGVVAPTLSYGYKSKPLSGGGPLFPGTIDLNGATLQALVMDIIDEFVRDGFKKIFLLSAHFENEAFIVEAMDLCSAKYGDKVEILLTNWWDPMSPDLIDKIFDEVPFPGWALEHAAVTETSLMMYFAPELVREDKILDTENATPGTYFKYPIEKGIVPETGILASAKSSSAKKGKMMVDDVVENIVKIINEAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE7</accession>
    <name>A0A386PGE7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02042"/>
    <dbReference type="EnsemblBacteria" id="AYE35145">
        <property type="protein sequence ID" value="AYE35145"/>
        <property type="gene ID" value="CP523_12350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017461357" description="Beta_helix domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1312"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="5">
        <location>
            <begin position="277"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1342" mass="148947" checksum="DF0A7A674918CA83" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT9</accession>
    <name>A0A386PGT9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-exporting P-type ATPase</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Copper-exporting P-type ATPase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cu(+)-exporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CP523_11510</name>
        <name evidence="18" type="ORF">EI377_06325</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673318.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02860"/>
    <dbReference type="EnsemblBacteria" id="AYE34990">
        <property type="protein sequence ID" value="AYE34990"/>
        <property type="gene ID" value="CP523_11510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60383">
        <property type="protein sequence ID" value="QAS60383"/>
        <property type="gene ID" value="EI377_06325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="73"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS60383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="812" mass="87198" checksum="8B16E3B602B0A1E1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU6</accession>
    <name>A0A386PGU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35293">
        <property type="protein sequence ID" value="AYE35293"/>
        <property type="gene ID" value="CP523_13140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="146" mass="16950" checksum="0DE5FC04B590388C" modified="2018-12-05" version="1">MKNKSKFIVSLIVGILLLSLGYNFYQQNKINNYKKELTQTVRDNIQNFAGYGGNIDNETVYAEQYASIIAARESYFALSDENGIPNDEWAYSLPRLFIEINRVMLNDKEKFKEVFQNENASELMFKISDNFDDKESINKVYSLLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV3</accession>
    <name>A0A386PGV3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04475</name>
        <name evidence="3" type="ORF">EI377_15015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676418.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00383"/>
    <dbReference type="EnsemblBacteria" id="AYE33782">
        <property type="protein sequence ID" value="AYE33782"/>
        <property type="gene ID" value="CP523_04475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61939">
        <property type="protein sequence ID" value="QAS61939"/>
        <property type="gene ID" value="EI377_15015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="31069" checksum="0CBC46DA84A3C377" modified="2018-12-05" version="1">MNYKDKKLSENEKFNIDIDFDNMVIPDLQGNIDEILDKGLKGKRNFFSFFKEVKNELGFKNIFHDKSELIFIGLILSIAVIMFGLYFNERENSNLDFTYKLKSYTFITAPIIYFFICSYNFINSRLNGTYEIQATCKYNFYTLTAIRMFIFSIISMVINTAIILIMFLVKRNFNVVEVVIVSITSLFIFSVIYILALVKLKERTYKYLVLIVWIGVSSIIMYGVNSKLAKYFLDSPIYINIGITCIVAVFYIKNLKKLIKVRRGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX1</accession>
    <name>A0A386PGX1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_07520</name>
        <name evidence="10" type="ORF">EI377_02210</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673806.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01113"/>
    <dbReference type="EnsemblBacteria" id="AYE34301">
        <property type="protein sequence ID" value="AYE34301"/>
        <property type="gene ID" value="CP523_07520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59695">
        <property type="protein sequence ID" value="QAS59695"/>
        <property type="gene ID" value="EI377_02210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="8">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="7">
        <location>
            <begin position="160"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="391" mass="42246" checksum="A10B20927A194166" modified="2018-12-05" version="1">MNIYEEALKYHGDLKGKFEIISRCKIKNEKDLSLAYTPGVAEPCKEIHKDPSKSYLYTRKWNTVAVISDGTAVLGLGDIGPLAALPVMEGKSILFKEFANVDAFPLVLDTKDTKEIIDTVIKIAPTFGGINLEDISAPRCFEIEKALKEKLDIPVFHDDQHGTAIVVLSGLLNGLKIVNKNLEDIKIVINGSGAAGSAICKLLLSSGAKNIIMCDKFGAIYNGMDFINESLEELSNITNPNKETGTLKDVIKNADVFIGVSAPNLVSKEMVKTMNKDSIIFAMANPIPEIFPDDAKEAGAKVIGTGRSDFPNQVNNVLAFPGIFRGALDVMASDINEDMKIAAAYAIANAISKDDLSPDFIIPKAFDINVQKLVAEAVKEAAIKSGVSRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX5</accession>
    <name>A0A386PGX5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13365</name>
        <name evidence="3" type="ORF">EI377_08255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677518.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35335">
        <property type="protein sequence ID" value="AYE35335"/>
        <property type="gene ID" value="CP523_13365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60726">
        <property type="protein sequence ID" value="QAS60726"/>
        <property type="gene ID" value="EI377_08255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362714" evidence="1">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="24072" checksum="BAA9F13D2DDD746D" modified="2018-12-05" version="1">MKMKKLSLLVATLALTVGLAGCMPGSNAKLPEGDVKVAKQEIQGVVDLLLKSADYGKDESTVASILLPQDSQYNINVVMEKYKDGKLVDTKEITNYTTEKIEKNSIVHMILNVGKASDGENSRSIYSIAEVDKEKTKDEKNPEYKLTKINEHSLDYDVKSEVAQIGKNLDEEVTLAGYVKFKEDDTEKPAINLDTYKDEVSKYKEVSIVKMKVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ7</accession>
    <name>A0A386PGZ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02755</name>
        <name evidence="4" type="ORF">EI377_13280</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676966.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00957"/>
    <dbReference type="EnsemblBacteria" id="AYE33459">
        <property type="protein sequence ID" value="AYE33459"/>
        <property type="gene ID" value="CP523_02755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61630">
        <property type="protein sequence ID" value="QAS61630"/>
        <property type="gene ID" value="EI377_13280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="195" mass="21265" checksum="F9504E6048B0A434" modified="2018-12-05" version="1">MCVVKKNTYEVIVIGASTGGPKAIEKVLKYLPYDLGVPVLIVQHMPRGFTKSFADRLNKCCNIRVLEATTGMKIEKNTAYIAPGGYHMEVESNNKIYLNEDPAIWGVRPAVDKLFESASKVYKKNVISVILTGMGRDGANGTKAIKEAGGTTISEDESTCTIYGMPKMAYETGAVDFVLPLHEISNKLKDLLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH06</accession>
    <name>A0A386PH06_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside triphosphate pyrophosphohydrolase</fullName>
            <ecNumber evidence="4">3.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08545</name>
        <name evidence="4" type="ORF">EI377_03295</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674875.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01650"/>
    <dbReference type="EnsemblBacteria" id="AYE34474">
        <property type="protein sequence ID" value="AYE34474"/>
        <property type="gene ID" value="CP523_08545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59876">
        <property type="protein sequence ID" value="QAS59876"/>
        <property type="gene ID" value="EI377_03295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11723">
        <property type="entry name" value="YabN_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024180">
        <property type="entry name" value="Tetrapyrrole_Mease/MazG_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035013">
        <property type="entry name" value="YabN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002845">
        <property type="entry name" value="Ttrprl_mtas_MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="251"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="392"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="486" mass="56187" checksum="5F95F010B66360F5" modified="2018-12-05" version="1">MIKIVGLGPGAPEALTVGTINVLEKSENIFFRTEKHPTVDYLRDKIKDFKTYDYFYEECSSFDDVYANIAKDIIEVYRDRGELVYAVPGHPLVAEKSVFNLIKLCEENDIEYKLVPAVSFVDAMMDSLKIDPIEGLKIIDAFDMKNQILDKRIGTIITQVYNQFIASEVKIQLLEYYNDDTEIYYVRAAGIEGEESVRKIPMYELDMQEDIDYLTSIYIPKDLNNKKDINDLIDIIDILRGENGCSWDREQTHESLKNQLLEEAYEVVDAINNDDIDAMIEELGDILLHVVFHASIGKEDGYFNMTDIVESISDKMIYRHPHVFKEKNKIDSETTIELWDELKKKEKNFKTITEDLQAIAKALPSLIRASKVQKKVSKVGFDWNNVEDASLKVEEELKEVLEVYKTENKEKIKEEVGDLLFACVNVARLLKVNEEEALNITIEKFIKRFSFIEEAAIKSNKILKDMSLEEMDELWNQAKKVEETIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD2</accession>
    <name>A0A386PHD2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33972">
        <property type="protein sequence ID" value="AYE33972"/>
        <property type="gene ID" value="CP523_05550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032871">
        <property type="entry name" value="AHH_dom_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14412">
        <property type="entry name" value="AHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="249" mass="27222" checksum="098259EF88144C2F" modified="2018-12-05" version="1">MGYLPEIANKIKNGERVEKIVDSIRGAKGAAEAVSKLKYTLKYSIDELAFQIKKVVSLGDVTVVELGNGITYAIRETDDVAEAARPAYREVIQGIWKYSGKTADEIADFYFSKVANKTKVSGKFSGSASDILRAELKDAGVITPPYKHQAHHIIPEGMDVPELNEVRAIMQRYGVDLNSASNGVFLPDAPDLPYAGSETVHRGSHTADYARYVAKAIIDVKPQSADDIVDVLNNLRKKLLNGTLKLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG8</accession>
    <name>A0A386PHG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05970</name>
        <name evidence="3" type="ORF">EI377_00450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01896"/>
    <dbReference type="EnsemblBacteria" id="AYE34046">
        <property type="protein sequence ID" value="AYE34046"/>
        <property type="gene ID" value="CP523_05970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59418">
        <property type="protein sequence ID" value="QAS59418"/>
        <property type="gene ID" value="EI377_00450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="315" mass="34435" checksum="9C934ED28E296CA0" modified="2018-12-05" version="1">MYFLGIDGGGTKTSFTLINEKGNVIHKTTMGTCHYNQIGFEKLEILLKEGLEKVLKVANISKGDIAQSFIGLAGYGRVEEVRIKIEEVVKKAFEGVNYILGNDVQVAIAGALKGQDGINIVSGTGSIALALKDKELIRVGGFGPAIGDEGSAYWIGKKALQLFSKEVDGRAKKGCLYNIFIKELSLKDDYEIISYVNDRIKCDRGEIAKLSKLCSLAALEGDEEASLIFKEAGKELAEMVKVLLKNYGDEKVLVSYTGGVFKSGKLILEPIRENLMKYNVKLIDPILSPDLGACLLAYMDLGYEVSNELIENMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR1</accession>
    <name>A0A386PHR1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate butyryltransferase</fullName>
            <ecNumber evidence="4">2.3.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptb</name>
        <name evidence="3" type="ORF">CP523_09275</name>
        <name evidence="4" type="ORF">EI377_04020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678309.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03043"/>
    <dbReference type="EnsemblBacteria" id="AYE34601">
        <property type="protein sequence ID" value="AYE34601"/>
        <property type="gene ID" value="CP523_09275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60001">
        <property type="protein sequence ID" value="QAS60001"/>
        <property type="gene ID" value="EI377_04020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050182">
        <property type="term" value="F:phosphate butyryltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014079">
        <property type="entry name" value="Phosphate_butyryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02706">
        <property type="entry name" value="P_butyryltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="78"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="301" mass="32363" checksum="68B8A81B1D73E2B3" modified="2018-12-05" version="1">MNKNFDDLLLKLKDCKKKRLAVAVAQDEPVLEAVKAAQERQIADAILVGDQEKISEISKKIDMDISKFEIVHEVDPKKATLQAVKLVSSGKADMVMKGLIDTATFLRSVLNKEVGLRTGKLMSHVSVFEIEGIDRLIFLTDAAFNTYPDLKAKVQILNNSVDVAHACGIENPKVALVCAVEVVNPDMQATVDASLLSKMNDRGQIKGCLVDGPLALDNAISEEAAHHKGITSPVAGKADVILLPNIETANVMYKTLTYTSKSKNGGLLVGTSAPVILTSRADSFETKVNSIALAALVAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS3</accession>
    <name>A0A386PHS3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YtfJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytfJ</name>
        <name evidence="2" type="ORF">CP523_15180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678591.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35665">
        <property type="protein sequence ID" value="AYE35665"/>
        <property type="gene ID" value="CP523_15180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014229">
        <property type="entry name" value="Spore_YtfJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39162">
        <property type="entry name" value="PTHR39162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09579">
        <property type="entry name" value="Spore_YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021377">
        <property type="entry name" value="YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02874">
        <property type="entry name" value="spore_ytfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="169" mass="18368" checksum="38D4883CA5EB9956" modified="2018-12-05" version="1">MTNEHPVENLMRSTMENLRDMIDVNTVIGEAVETRDGSYIIPISKVTFGFASGGSEFGAATKQSSPNESKHPFGGGSGAGVTVKPVAFLVVREDSVRLLPVNQDNACDRVVDSIPTVLDMFKNFFNDMSKNKNGKKNNDNLESTNCNTCNSKIDECVCDDSDSSSNNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT0</accession>
    <name>A0A386PHT0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium/sodium antiporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sodium:proton exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_13440</name>
        <name evidence="8" type="ORF">EI377_08335</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677563.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00783"/>
    <dbReference type="EnsemblBacteria" id="AYE35350">
        <property type="protein sequence ID" value="AYE35350"/>
        <property type="gene ID" value="CP523_13440"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60741">
        <property type="protein sequence ID" value="QAS60741"/>
        <property type="gene ID" value="EI377_08335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="177"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="320" mass="34115" checksum="6EC5F375954505B9" modified="2018-12-05" version="1">MNYIILIIGFVLLIKGADIFVDGAATIAKKLGIPAVIVGLTIVSLGTSAPELAISLISSIQGNNGITIGNVLGSNIFNTLMVLGVTAIIMPILIKKTTIIKDYIINVLISILLLILTFAPTLFSGEAIITRLDGIIFLIVCIAYIIYLIISAKRTNKNNEDKEEGKNINVISCILKVIIGVAGVIIGGKLVVDAATNIAYSFGMSEKLVGLTIVAVGTSLPELVTSMVAAIKGENDIAIGNVLGSNIFNILLILGMSAIINPIPVAINLSIDMIFLIIISIILGIFMFYGKDKETKLSKFEGIILVTMYIGYVIYIVMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV7</accession>
    <name>A0A386PHV7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_13600</name>
        <name evidence="7" type="ORF">EI377_08495</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679026.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35380">
        <property type="protein sequence ID" value="AYE35380"/>
        <property type="gene ID" value="CP523_13600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60770">
        <property type="protein sequence ID" value="QAS60770"/>
        <property type="gene ID" value="EI377_08495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01046">
        <property type="entry name" value="Rubrerythrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045236">
        <property type="entry name" value="Rubrerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="51"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="19985" checksum="BF36B83CECF1F330" modified="2018-12-05" version="1">MKKFVCTVCGYIHEGNTPPEICPVCKVGADKFIEMSDDLNWADEHRIGIAEGINPEVIDGLRANFIGECTEVGMYLAMSRQADREGYPEVGEAYKRIALEEAEHASRFAEMLGEVVAADTKANLKARVEAEYGACDGKKKLATLAKQNNLDAIHDSVHEMCKDEARHGRAFKGLLDRYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW4</accession>
    <name>A0A386PHW4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tagatose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09615</name>
        <name evidence="3" type="ORF">EI377_04390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676694.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02629"/>
    <dbReference type="EnsemblBacteria" id="AYE34661">
        <property type="protein sequence ID" value="AYE34661"/>
        <property type="gene ID" value="CP523_09615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60061">
        <property type="protein sequence ID" value="QAS60061"/>
        <property type="gene ID" value="EI377_04390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09615"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012062">
        <property type="entry name" value="GatZ/KbaZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08013">
        <property type="entry name" value="GatZ_KbaZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009264">
        <property type="entry name" value="TagBP_ald_AgaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="445" mass="50750" checksum="0B7592214A2F6C58" modified="2018-12-05" version="1">MVHPIKEIVTKYKQGENVGIFSVCSSNKYVIEAAMDRLRNMEMYLLVESTANQVDQFGGYTGMKPKDFVKYIHNLAEKNNFPIDRIILGGDHLGPLTWTKIEPREAMDNAKTLIREYVLAGFTKIHIDTSMPLRGDIEKGIFDDYLIANRASVLCKVAEEAYLELLEKEENAIHPVYVIGSEVPIPGGAQGEEEDEGEISVTKVESFVNTIDTFKNAFENFGVGEAWKYVIGVVVQPGVEFGSDHVWGYNREAAQRLTEAIQEHSQLVFEAHSTDYQTPKALKEMVEDGYIILKVGPALTFGFREGVFALNSIENELFKYNPDIDLSNFQEILEFSMVKEPKDWENHYLGTSEKIKIDRKYSLSDRCRYYMPKEDVNFALEKLLKNLNGVQIPITLVSQFMHNQYKKVRNGELELNAQSLLKDRIGEYIDDYIFATEESKVLQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI61</accession>
    <name>A0A386PI61_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminoacetone oxidase family FAD-binding enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NAD(P)/FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07495</name>
        <name evidence="2" type="ORF">EI377_02185</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01108"/>
    <dbReference type="EnsemblBacteria" id="AYE34296">
        <property type="protein sequence ID" value="AYE34296"/>
        <property type="gene ID" value="CP523_07495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59690">
        <property type="protein sequence ID" value="QAS59690"/>
        <property type="gene ID" value="EI377_02185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="415" mass="45736" checksum="069B9AEA2F98F7D6" modified="2018-12-05" version="1">MIHHDLIIVGGGASGLIAAIAAKDFGIDVAILEATDRIGKKILTTGNGRCNISNNTISFPFLSYHSENPNFFVNSLSNFMVEDTKSFFLSLGLPITELKGGKMYPQSLQASSVVDIFRFALEERGIPLYTNCKLKDIHRKKNFNLSTSNEEYKLFTCEKLILACGGKSAVKTGSDGSGHSLAKSLGHKIINPLPGIVQLKLEHPHLKALSGIKFDGYAILLINDKPIRKEFGEILFTDYGISGPPILQLSGHASKALHKGKKVEIIVDMMPNLSLEDVENFIERHLAMFSHRSVLDSLIGIVNKKLIPTLLKEAGITNLHCPCYDLDWKDRRRLIDLLKQWKFKCIGTNGFNQAQVTIGGVNTKEVDPITLESKLVPNLYFCGEILDVDGDCGGFNLQWAWSSGYCVAKNIANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA2</accession>
    <name>A0A386PIA2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 9">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_09210</name>
        <name evidence="12" type="ORF">EI377_03955</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678333.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03056"/>
    <dbReference type="EnsemblBacteria" id="AYE34588">
        <property type="protein sequence ID" value="AYE34588"/>
        <property type="gene ID" value="CP523_09210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59988">
        <property type="protein sequence ID" value="QAS59988"/>
        <property type="gene ID" value="EI377_03955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09210"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="10">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="743" mass="85565" checksum="FFD666A647E75744" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA4</accession>
    <name>A0A386PIA4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33889">
        <property type="protein sequence ID" value="AYE33889"/>
        <property type="gene ID" value="CP523_05065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="349" mass="39068" checksum="6AF19AA730C9E4CF" modified="2018-12-05" version="1">MNILMVGPSIKLQGGVATVVSNYLNSKLSESFNIKYIPTVDGDKKIGKAFAAVKAYIIILLNLIFNNIDIVHVHMASRGSFYRKSLIICLASLFNKKIVIHLHGAQFNEFYHMESNDNEKRKITNILNKADVIIALSNKWKEDLTKITKAKIVVIHNSVNCCKHNMYKVNSKNIIFLGRVDERKGAFDLIEVSKNIFKKYPRYNLLLCGDGDLKKVKSFIDGMDLAEHVKALGWISGKEKDDIMKDAVINILPSYNEGLPMSVLEAMGCGIPTIASNVGGIPDVIKDNINGFLIIPGDKINLEEKICKLLENEELRISMSDLAFKTVSGKFNINTNIAEVENLYNFLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC6</accession>
    <name>A0A386PIC6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pheS</name>
        <name evidence="15" type="ORF">CP523_14600</name>
        <name evidence="16" type="ORF">EI377_09570</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678666.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00192"/>
    <dbReference type="EnsemblBacteria" id="AYE35560">
        <property type="protein sequence ID" value="AYE35560"/>
        <property type="gene ID" value="CP523_14600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60947">
        <property type="protein sequence ID" value="QAS60947"/>
        <property type="gene ID" value="EI377_09570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="14">
        <location>
            <begin position="117"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE35560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="339" mass="38186" checksum="8BFD83DD0BB28D8F" modified="2018-12-05" version="1">MQEKLIAIKEAAFKELQEVNSSVVLEEIRVKYLGKKGELTTILRGMGALSAEERPVVGKLVNVIKKEVEDKIEETSKGIKEKEKNAKLASEVIDISLPGKKNVIGKRHPLDLTLESMKNIFISMGFTVEEGPEVELDHYNFEALNIPKNHPARSEQDTFYINDNLVLRTQTSPVQIRVMEDQQPPIKMIAPGKVYRSDAVDATHSPIFYQMEGLVIDKGVTFADLKGTLELFAKKMFGDKVKTKFRPHHFPFTEPSAEMDATCFVCQGEGCRVCKGSGWIELLGCGMVHPQVLRNCGIDPEVYSGFAFGFGVDRMVMLKYGIDDIRLLYESDMRFLNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID7</accession>
    <name>A0A386PID7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proB</name>
        <name evidence="9" type="ORF">CP523_08010</name>
        <name evidence="10" type="ORF">EI377_02770</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00717"/>
    <dbReference type="EnsemblBacteria" id="AYE34372">
        <property type="protein sequence ID" value="AYE34372"/>
        <property type="gene ID" value="CP523_08010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59778">
        <property type="protein sequence ID" value="QAS59778"/>
        <property type="gene ID" value="EI377_02770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08010"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="221"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="29087" checksum="2647AE46D1320CBB" modified="2018-12-05" version="1">MSYREKIKSAKRVVVKVGTSTLTYDNGNINLTRIEKLTRILSDMINSGKEVTLVTSGAIGVGVNKLKLKEKPTSIREKQAVASVGQCELMHIYSKFFGEYSHVVGQVLLTRDVVEDDHIRENVCNTFETLLEKGIIPIVNENDTVSIDEIENIVRFGDNDNLSAIVAKLVKADLLIILSDIDGFYDSDPRCNPNSKLLKEIDEITPELEECCGGAGSNLGTGGMVTKLTAAKTATEAGVNMILANGKEPEILLDILDGKEIGTLFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF1</accession>
    <name>A0A386PIF1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14535</name>
        <name evidence="3" type="ORF">EI377_09505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678686.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00205"/>
    <dbReference type="EnsemblBacteria" id="AYE35883">
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        <property type="gene ID" value="CP523_14535"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Methyltransf_25"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="247" mass="29207" checksum="3666316A65FAFC5D" modified="2018-12-05" version="1">MAYGEFAKIYDELINEDINYDEMVNRIIEVCSKYNVDFTNYLDIACGTGNVTVRLAKYFKDNYAVDLSEDMLREAFDKFKEKRVKCKVICQDMAELSLNRKFDLITSVLDSTNYIIEEESLINYFKGVKEHLSDEGIFIFDINSYYKLSEILGNNIYTYSEEEVFYTWENTFEDNLLSMFLTFFVKKGEFYERFEEEHLERAYKESYLESILSMVGLQVLEKCSGYSKENVSDKSERIMYVVKKVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG8</accession>
    <name>A0A386PIG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR01906 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11260</name>
        <name evidence="3" type="ORF">EI377_06070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34944">
        <property type="protein sequence ID" value="AYE34944"/>
        <property type="gene ID" value="CP523_11260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60338">
        <property type="protein sequence ID" value="QAS60338"/>
        <property type="gene ID" value="EI377_06070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010178">
        <property type="entry name" value="Integral_membrane_1906"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07314">
        <property type="entry name" value="DUF1461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01906">
        <property type="entry name" value="integ_TIGR01906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="27434" checksum="7FCA8CE05D61109E" modified="2018-12-05" version="1">MTLKRNKEKNLYKNFLNIFLGIITSFFSIGISVIATLNLTIVYRFAITKLNLDKLTGLSEENLMKNYNEMIKYLNNPFINELKFPDFTMSKTGEIHFMEVKYIFMKIYIIILISIIIFMLFKLIKMLYNAINVVKILNYASNMIISIFGFIIIMMLIDFKKAFIVFHKIFFNNNYWLFDPYTDPIINALPEELFLAYALIIVGILAVQVIAFKVVYYLDKKHNDELVPFNTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII2</accession>
    <name>A0A386PII2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">CP523_09655</name>
        <name evidence="13" type="ORF">EI377_04435</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02637"/>
    <dbReference type="EnsemblBacteria" id="AYE34668">
        <property type="protein sequence ID" value="AYE34668"/>
        <property type="gene ID" value="CP523_09655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60068">
        <property type="protein sequence ID" value="QAS60068"/>
        <property type="gene ID" value="EI377_04435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09655"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="196"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="510" mass="57075" checksum="3519E7BE8F7E2C40" modified="2018-12-05" version="1">MKKELVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYTIEKIKAKNPKGIIFTGGPNSVYGENTPKVADGIFDLGIPVLGICYGDQLMAHMLGGNVDTAPVREYGKTNVNLDNTSRLFEGIEKEEICWMSHTDYVKEAPAGFRIIGYTEVCPIAAMENEDRKLYGVQFHPEVEHTPFGQKMLSNFLHNICGLGNNWTMASFAEDKINEIKQLVGDKKVLCALSGGVDSSVAAMLVHKAIGHNLTCIFVDHGLLRKDEGDTVERVFKKEFDMNIIRVNAADRFLGKLKGVSDPETKRKIIGEEFIRVFEEEANKLGAIDYLVQGTIYPDIVESGTDTSATIKSHHNVGGLPEDMQFDLIEPLRELFKDEVRAVGEELGIPHKLVWRQPFPGPGLAIRVLGEITEEKLEIVREADAIFREEIANAELDESIWQYFACLPNIKSVGVMGDERTYSHTVALRAVTSSDAMTSEWARLPYELIDLVSRRIVNEVKGVNRIVYDVTSKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN5</accession>
    <name>A0A386PIN5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="7">3-dehydroquinase</shortName>
            <ecNumber evidence="5 7">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">aroQ</name>
        <name evidence="11" type="ORF">CP523_11410</name>
        <name evidence="12" type="ORF">EI377_06225</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673275.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02839"/>
    <dbReference type="EnsemblBacteria" id="AYE34971">
        <property type="protein sequence ID" value="AYE34971"/>
        <property type="gene ID" value="CP523_11410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60364">
        <property type="protein sequence ID" value="QAS60364"/>
        <property type="gene ID" value="EI377_06225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11410"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7 10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="142" mass="16102" checksum="DD4C5E27ECC6656F" modified="2018-12-05" version="1">MKIMVINGPNLNMVGVREKSIYGVRDFSDICKYIEEEGNKRGVEITFFQSNIEGEIVNNIHKAYFEKYDGIIINPGAYTHYSYAILDAIKAVDINTIEVHLSNIHAREEFRHKSVTASACIGQICGFKEYGYIMAMDALINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS2</accession>
    <name>A0A386PIS2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_05775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674960.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01855"/>
    <dbReference type="EnsemblBacteria" id="AYE34009">
        <property type="protein sequence ID" value="AYE34009"/>
        <property type="gene ID" value="CP523_05775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="403"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="504" mass="58883" checksum="FFA06DEDB1B06AB2" modified="2018-12-05" version="1">MYKVMLVDDEKLILQGLLNIIEWDKLDLEVIHLAEDGMEALEKFKDNPVDIIVTDINMPRLTGLELLKEIKALDSNVKFIILSGYDEFSYARTAIKLGVENYILKPIDEEELESSLKKLKKKIEEEKSKDIKVLEKNRLLIEFINGKINKDDLDYIRDVINLDFKEKSYTVSSIKISNKDVNENNNICEIIKGITNEKFEVLYKFDGHIVLINSWNENISKEEILNYYNNVNKKLAKDFNADVFIAIGDRVDSIENLKESYRVSNHLKKYILTEGSNICLCKDDVEKLEKDNRSFNMEIENINKLIIEKNKSELEKYILNIFEEHLTPRNIYDLSIKTILLIDKVSDEFKLELKYRRDSLRDTLVELCNESAIDNIKSFILGEIDELMELMTSNTIKYSPVVQQVVNNVNEKYYEELSLKTLAQQYNINSSYLGQIFTKEVGASFSDYLNKVKNMKAKELILNTNMKINDIAKAVGYFDTSYFYRKFKKYYGVCPSTLREMKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU4</accession>
    <name>A0A386PIU4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZupT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">zupT</name>
        <name evidence="6" type="ORF">CP523_13375</name>
        <name evidence="7" type="ORF">EI377_08265</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677523.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35337">
        <property type="protein sequence ID" value="AYE35337"/>
        <property type="gene ID" value="CP523_13375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60728">
        <property type="protein sequence ID" value="QAS60728"/>
        <property type="gene ID" value="EI377_08265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="28423" checksum="B72894753D28D488" modified="2018-12-05" version="1">MFSNHCLMPLILSSLAGMSTVIGAFIVFFSKSKNKKLICFSLAFSAGVMISVSFTDLFSTAEETLRKSQGNLKGICYTILFLVIGAFIAMLIDMFIPEEPRLIASQRGNKLYRVGFVSMIALMIHNFPEGVATFVSGYENTTLGITIALAIALHNIPEGISIAMPIYYSTGSKLKAFKYTFVSGLAEPIGALLALLFLRPFINEIILAIIFAIVSGIMLYISFEELIPTARKYGYDKLYIFSIFLGICIIPLSHVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIV7</accession>
    <name>A0A386PIV7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription antiterminator BglG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_12240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03003"/>
    <dbReference type="EnsemblBacteria" id="AYE35124">
        <property type="protein sequence ID" value="AYE35124"/>
        <property type="gene ID" value="CP523_12240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="91"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="444"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-4" evidence="3">
        <location>
            <begin position="552"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="797"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="896" mass="103052" checksum="BE06BCABB2F4A748" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ16</accession>
    <name>A0A386PJ16_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpC</name>
        <name evidence="6" type="ORF">CP523_11025</name>
        <name evidence="7" type="ORF">EI377_05820</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677111.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00934"/>
    <dbReference type="EnsemblBacteria" id="AYE34898">
        <property type="protein sequence ID" value="AYE34898"/>
        <property type="gene ID" value="CP523_11025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60293">
        <property type="protein sequence ID" value="QAS60293"/>
        <property type="gene ID" value="EI377_05820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="369" mass="41524" checksum="5923B726600AF9F5" modified="2018-12-05" version="1">MANLSLQHIYKIYPGDVTAVKDFNLEIADKEFIVFVGPSGCGKSTTLRMIAGLEEISKGELYIDDKLVNDVPPTDRDIAMVFQNYALYPHMTVYENMSFGLKLRKMPKAEIDVKVREAAKILDIEHLLDRKPKALSGGQRQRVALGRAIVREPKVFLMDEPLSNLDAKLRVQMRTEISKLHQKLQTTFIYVTHDQTEAMTMGTRIVVMKNGIVQQVDSPQEIYSHPANMFVAGFIGSPQMNFIDAEVKEVGEKLTLNFGKETILVPEDKAKIIREKGYIGKTVVLGIRPEDMYDDSNYINEHPDSIFDANVEVTELMGAESYIYINKDGVAMTVRVNGSTKLQNGQIAKFAMDTKAIHIFDKESELAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJH4</accession>
    <name>A0A386PJH4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpE</name>
        <name evidence="5" type="ORF">CP523_11995</name>
        <name evidence="6" type="ORF">EI377_06815</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673468.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02956"/>
    <dbReference type="EnsemblBacteria" id="AYE35078">
        <property type="protein sequence ID" value="AYE35078"/>
        <property type="gene ID" value="CP523_11995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60471">
        <property type="protein sequence ID" value="QAS60471"/>
        <property type="gene ID" value="EI377_06815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="21864" checksum="EA3F4801D1EDD5B1" modified="2018-12-05" version="1">MSNVNNLTSKILKDSEERKGKILASAEEEKNKILSKKVNKAKELEAEMIAKAKLEAKTRKERILSAAALKVRNNKLAAKQEVIQDVFKSSVDKLTKISKEQFLSFVRESILSLGEIGDQTLILNNDGIEMVDIAFIYELNEALGNNGNIKLSSKAGEFKGGFILEKNGIEINNTYEALVSSLRDELEFEVARVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP0</accession>
    <name>A0A386PJP0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13900</name>
        <name evidence="4" type="ORF">EI377_08795</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678795.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00147"/>
    <dbReference type="EnsemblBacteria" id="AYE35431">
        <property type="protein sequence ID" value="AYE35431"/>
        <property type="gene ID" value="CP523_13900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60819">
        <property type="protein sequence ID" value="QAS60819"/>
        <property type="gene ID" value="EI377_08795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="577" mass="67161" checksum="2E1C18DA41F0AFD5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP6</accession>
    <name>A0A386PJP6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">queA</name>
        <name evidence="6" type="ORF">CP523_14175</name>
        <name evidence="7" type="ORF">EI377_09080</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678521.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00287"/>
    <dbReference type="EnsemblBacteria" id="AYE35484">
        <property type="protein sequence ID" value="AYE35484"/>
        <property type="gene ID" value="CP523_14175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60870">
        <property type="protein sequence ID" value="QAS60870"/>
        <property type="gene ID" value="EI377_09080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14175"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="341" mass="38852" checksum="58D1B7B0AC607E24" modified="2018-12-05" version="1">MKVSDFDFYLPEELIAQHPLERRDSSRLMVLDRNTGDVEHKHFHDIIEYLNEGDTIVLNNTRVMPARLIGEKEGTGGKIEFLLLKRIEGDKWECLAKPGKKAKIGQKFVFGSGKLNCEVIDIIEEGNRIIEFSYEGIFEQVLDELGEMPLPPYITERLEDRERYQTVYSKEKGSAAAPTAGLHFTEELLNEIKAKGINIAYLTLHVGLGTFRPVKAETIDEHVMHSEYYSLDEKDAEIINDTKIRGNRVISVGTTSTRTLETIANEDGLVRPQSGWTNIFIYPGYKFKVVDNLITNFHLPESTLIMLVSALAGKENVMNAYKEAVEEKYRFFSFGDSMFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJT4</accession>
    <name>A0A386PJT4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">CP523_14210</name>
        <name evidence="13" type="ORF">EI377_09115</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678506.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00280"/>
    <dbReference type="EnsemblBacteria" id="AYE35491">
        <property type="protein sequence ID" value="AYE35491"/>
        <property type="gene ID" value="CP523_14210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60877">
        <property type="protein sequence ID" value="QAS60877"/>
        <property type="gene ID" value="EI377_09115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14210"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="36"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="172" mass="18787" checksum="D627EE602C3B4F71" modified="2018-12-05" version="1">MDLKEKIRIIDGFPKEGISFKDITTAIGDGEALKYSIDKMVEHLKDKNIDLIVGPEARGFIYGVPVAYAMGIGFVPVRKPGKLPGETVSVDYDLEYGKDTLQIHKDSIKKGQRVAIVDDLLATGGTIEAVAKLVEIAGGEVVSLEFAIELTDLKGRDKLKGYDVMSLVQYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK16</accession>
    <name>A0A386PK16_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_11620</name>
        <name evidence="8" type="ORF">EI377_06435</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673359.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02882"/>
    <dbReference type="EnsemblBacteria" id="AYE35012">
        <property type="protein sequence ID" value="AYE35012"/>
        <property type="gene ID" value="CP523_11620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60405">
        <property type="protein sequence ID" value="QAS60405"/>
        <property type="gene ID" value="EI377_06435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362732" description="Lipoprotein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="5">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002854-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="270" mass="29824" checksum="314ED21F74A08703" modified="2018-12-05" version="1">MKRKSIVSVLLAGVLAIGLIGCGNKGASEDKVIKIGVSPVPHKEIVEHIVPELEKEGYEVKIVEFTDYVTPNTALAEGELDANYFQHISYLNETNDSKKLDLAYTAEIHLEPIALYSKSIKNLNDLKNEATIAIPNDPSNEARALRLLEKQGLIKLKDGELITPKDIVENKKNFKFKELEAAQMPRVLEEVDAAIINGNYAIEAGLNPSKDALVIEDKDAEAARIYRNILAVKKGNEKLEKINALTKALTSDSVKKFINEKYNGAVIPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK21</accession>
    <name>A0A386PK21_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PRD domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">PTS fructose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_11435</name>
        <name evidence="8" type="ORF">EI377_06250</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02844"/>
    <dbReference type="EnsemblBacteria" id="AYE34976">
        <property type="protein sequence ID" value="AYE34976"/>
        <property type="gene ID" value="CP523_11435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60369">
        <property type="protein sequence ID" value="QAS60369"/>
        <property type="gene ID" value="EI377_06250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRD" evidence="6">
        <location>
            <begin position="270"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="5">
        <location>
            <begin position="381"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="4">
        <location>
            <begin position="489"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="625" mass="72268" checksum="506CCB56D9B5CB31" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK49</accession>
    <name>A0A386PK49_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13490</name>
        <name evidence="2" type="ORF">EI377_08390</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677579.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35358">
        <property type="protein sequence ID" value="AYE35358"/>
        <property type="gene ID" value="CP523_13490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60749">
        <property type="protein sequence ID" value="QAS60749"/>
        <property type="gene ID" value="EI377_08390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037208">
        <property type="entry name" value="Spo0E-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140500">
        <property type="entry name" value="SSF140500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="67" mass="7998" checksum="0E27BC7E6A0D399A" modified="2018-12-05" version="1">MFKISYNNKITYRKLLLNFLLKYLSPTNPIIIYVSQNLDKLIVDSQKTIYENHIKNTLFRKAYKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK65</accession>
    <name>A0A386PK65_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpB</name>
        <name evidence="7" type="ORF">CP523_12015</name>
        <name evidence="8" type="ORF">EI377_06835</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673475.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02960"/>
    <dbReference type="EnsemblBacteria" id="AYE35082">
        <property type="protein sequence ID" value="AYE35082"/>
        <property type="gene ID" value="CP523_12015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60475">
        <property type="protein sequence ID" value="QAS60475"/>
        <property type="gene ID" value="EI377_06835"/>
    </dbReference>
    <dbReference type="GeneID" id="66302297"/>
    <dbReference type="KEGG" id="csep:CP523_12015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="5">
        <location>
            <begin position="131"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="460" mass="51085" checksum="121862E8683D4CDD" modified="2018-12-05" version="1">MLKEYRTVTEVVGPLMVVEGVEGVKYDELVEVELQTGEKRRGKVLEIQGSKAMVQLFEGSSGINLKGTKAKFLGRPLELGVSEDMLGRIFDGMGNPIDNGPNIIPEQRLDINGEAINPVSRDFPSEFIQTGISAIDGLNTLVRGQKLPVFSGSGLPHKELAAQIARQARVLNSDSNFAVVFAAIGITFEESQFFVEEFQRTGAIDNAVLFMNLASDPAIERIATPRMALTCAEYLAYEKGMQVLVILTDITNYAEALREVSAARKEVPGRRGYPGYLYTDLSTLYERAGRIRGREGSITQIPILTMPEDDKTHPIPDLTGYITEGQIILSRELYKKGIMPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFSAYAQGKQAKELSAILGESALSDTDKQYAKFAEAFENEYVSQGFTTNRTIEETLQLGWKLLKILPKTELKRIRDEYLEKYMPKGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK74</accession>
    <name>A0A386PK74_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673402.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02914"/>
    <dbReference type="EnsemblBacteria" id="AYE35036">
        <property type="protein sequence ID" value="AYE35036"/>
        <property type="gene ID" value="CP523_11775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="237" mass="26270" checksum="7C97D2FB5DD018F1" modified="2018-12-05" version="1">MLKVVNYSKVYKGNKKAVNNISIEIESGDIFGFIGHNGAGKTTTIKSIVGILNFDEGEIIIDGISIKEEPIKCKKNIAYIPDNPDLYDSLTGIQYLNFISDIYNISKIDRENLIKKYGEAFEITKSLGDLISSYSHGMKQKLAIISALIHRPKLLILDEPFVGLDPKASHTLKEIMKRMCSEGGVIFFSTHVLEVAEKLCNKIAIIKDGAIVASGETKKVIGDNTLENVFMELIENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK82</accession>
    <name>A0A386PK82_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_11825</name>
        <name evidence="10" type="ORF">EI377_06645</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02923"/>
    <dbReference type="EnsemblBacteria" id="AYE35046">
        <property type="protein sequence ID" value="AYE35046"/>
        <property type="gene ID" value="CP523_11825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60439">
        <property type="protein sequence ID" value="QAS60439"/>
        <property type="gene ID" value="EI377_06645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11825"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="30117" checksum="4DBD0D55C99C1C35" modified="2018-12-05" version="1">MIFDSHMHSKFSTDSNMRIEDAIKISKNKNIGLIITEHMDLDYYNPNEFRCDVPAFFEEYNKFRCNTLGLGIELGLSESTLKSNENIAKNFEFDFILGSIHNINGSDIYSEYCKLSKNNYPKKDYFQKYLDSMLSCVKLYNNFDSLSHIDYLCRYSYYDDNEIDIEIYKDTIAEIVQTLLEKGKVMELNSSRLNNGKAQESLLKIYRLYNDLGGKYLTIGSDAHTANDIGRNFKIALDMCEFLKLKGVYFKKRKIELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKA3</accession>
    <name>A0A386PKA3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_11985</name>
        <name evidence="10" type="ORF">EI377_06805</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673466.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02954"/>
    <dbReference type="EnsemblBacteria" id="AYE35076">
        <property type="protein sequence ID" value="AYE35076"/>
        <property type="gene ID" value="CP523_11985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60469">
        <property type="protein sequence ID" value="QAS60469"/>
        <property type="gene ID" value="EI377_06805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="651" mass="73170" checksum="C8F5CA991C769E95" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKC8</accession>
    <name>A0A386PKC8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09950</name>
        <name evidence="3" type="ORF">EI377_04735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676547.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00319"/>
    <dbReference type="EnsemblBacteria" id="AYE34699">
        <property type="protein sequence ID" value="AYE34699"/>
        <property type="gene ID" value="CP523_09950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60100">
        <property type="protein sequence ID" value="QAS60100"/>
        <property type="gene ID" value="EI377_04735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="105"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="38546" checksum="F2CD5B000881E397" modified="2018-12-05" version="1">MKLLPHSNGLYKVNMKKPMKPKDIAKRTLIVIGILLLLGLVFQNISNFIAKETLKDRVDYTRVDDKRVDYIVKGEGKHTIIFDGAIGGNLNQWNDVCDKLLSEYDDITVFVYNRRGYGFSDGGQDRTPLEQAHDLKILLRKAALSPPYILVGEEYGSLVLGNFAKEYKETVAGVVLVNPIVEEKIKEKDFKRGFTLEKIRRKIEHLGSYIGLTTLLDQLNLDTKVYGFEDKLQGEKLEEFKVHRTKSNYTSAVYNELNNVSKGLSDSQETGVLSGIPYYVIAKEGQESLERLGDEDLTKVYKTNSNSNFISIEDPDAVVIGIRQVIKKVNDMERRNKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKT1</accession>
    <name>A0A386PKT1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677834.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35276">
        <property type="protein sequence ID" value="AYE35276"/>
        <property type="gene ID" value="CP523_13055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="66" mass="7930" checksum="59022F47D69D5C5C" modified="2018-12-05" version="1">MYNNLEAEIARKKLKKPIIAKEIRKTYNTLNLKISGKYPFTYDEALLIHEKFFPECDFKSLFKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKT5</accession>
    <name>A0A386PKT5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13720</name>
        <name evidence="2" type="ORF">EI377_08610</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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            <strain evidence="2 4">VAT12</strain>
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        <source>
            <dbReference type="EMBL" id="QAS60790.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="286" mass="32476" checksum="59A2D5043ED1B89B" modified="2018-12-05" version="1">MKILTYTILNSDLDSKIELLQINDIFNVFYDAPLEITKDNYGYGYLEKTDEPIKLKVAFDENEKDFEEFKNLVTSLLETKLESIEEVNYDYTNYDFPIIEINDEWVLASPDENINNKNKINFISQGAFGTGMHETTKDLLNLILTKLDLQDKNILDIGTGSGILSIASSIIGASSVTALDIRDVTDEVELNASLNGLYNVNILIGDVLSGEIKINDKFQWIYINIGGEETKLFMDFIKEHLAVNGNILVSGLVEWSFDEVRQAIESYGFNLKEKYQTNEWVTAVFN</sequence>
</entry>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
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            <dbReference type="EMBL" id="QAS60685.1"/>
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            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="64" mass="7522" checksum="AFF600B969394F04" modified="2018-12-05" version="1">MNKCMYCNNQVFVRNQYYCTRYKKKIYNNGTKLIPLDLCSLKSQNSNLYEFKTKSNGGILVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
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        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="AYE35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="107" mass="12107" checksum="A978A37063181C71" modified="2018-12-05" version="1">MTYLNDEIMLTSTDMYNFIKDELKPTTFYINPQKGSNIQGRAKIGFIAHDIQNTKIGQYLIGYDPDGYLCYDVGSRIGVVENALKVAINKIEALEREIENLKDKGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKX1</accession>
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        <submittedName>
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        <submittedName>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
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            <strain evidence="4 6">VAT12</strain>
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            <end position="164"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="177" mass="19378" checksum="8AB75659CE209746" modified="2018-12-05" version="1">MDPYKVLGVQPGASSDDIKNAYNNILANYNVNMNNLSINNSTEKALTDANIAYDLLINGNLYKEIRNLIEHNNFVLAESKLNLIDHRNSAEWNYLQGFISLKKGWFDTAVNHIKAATDLDPENPEYKDSLITLQSRANEIMNVYKQNNPKTNPPGGNNNMGGCPGGNTGGGGNGGMC</sequence>
</entry>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
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    </reference>
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        <property type="protein sequence ID" value="QAS60859.1"/>
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        <property type="protein sequence ID" value="AYE35472"/>
        <property type="gene ID" value="CP523_14115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60859">
        <property type="protein sequence ID" value="QAS60859"/>
        <property type="gene ID" value="EI377_09020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021598">
        <property type="entry name" value="DUF3221"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11518">
        <property type="entry name" value="DUF3221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="120" mass="13504" checksum="3E6ED42FBBD51373" modified="2018-12-05" version="1">MKIKRLILGFLLFMIIGVVPVYAKPPRSPVMIGEIIEVQKAEGENIIKILVDGYLKGGEILKEQVLVLINEETVVMDSSNDTKEKIEFEKGDKVYVRLNDAMTKSIPPQATAKRVYISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL99</accession>
    <name>A0A386PL99_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14990</name>
        <name evidence="3" type="ORF">EI377_09945</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676046.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35632">
        <property type="protein sequence ID" value="AYE35632"/>
        <property type="gene ID" value="CP523_14990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61019">
        <property type="protein sequence ID" value="QAS61019"/>
        <property type="gene ID" value="EI377_09945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="130" mass="15222" checksum="134CDB54D526DE05" modified="2018-12-05" version="1">MKSYVENKNFIPKSYFKEKELRLKRDRSKGLLLLIILNIIVFPLTINNFFVKEDLIIEESNIEEEFSSEKIKNIISEIDKDIKHLKIKNGSGEILVNGKEKLYSIESTESFIIENIKKLENNEFLVSIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLE3</accession>
    <name>A0A386PLE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12795</name>
        <name evidence="3" type="ORF">EI377_07670</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678185.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02796"/>
    <dbReference type="EnsemblBacteria" id="AYE35229">
        <property type="protein sequence ID" value="AYE35229"/>
        <property type="gene ID" value="CP523_12795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60624">
        <property type="protein sequence ID" value="QAS60624"/>
        <property type="gene ID" value="EI377_07670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="91"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="36142" checksum="A0AA3B206ACB11A1" modified="2018-12-05" version="1">MKKRNKIILSIVLVGLILFSTVTYIVGQMVYNGSVGSKTEVAKDEMIDFYSKKEDKRLETLNKYKHEKLFVKNPKNGYDIEVMNIKSNKETNDVIVIVHGIESNYYEVLNSAFNYLENGYNVVVYNQRHTGETGGENYTFGLYERFDLDEVVNYAASTYKDGILGVHGFSMGAATSTMHTELNEEKKKVDFYILDAPYHTMESAINLGITGKDVPLIPVKFAEWAGNLYTKTKAGFSYDDIEPYKAVKNITVPVMLIHGEDDTTTSPGSSKIIYDNIPHDKKELWLIPGLKHCKADDLIPEEYFNRIYNFIDKNVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLG7</accession>
    <name>A0A386PLG7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14855</name>
        <name evidence="4" type="ORF">EI377_09810</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676095.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01312"/>
    <dbReference type="EnsemblBacteria" id="AYE35606">
        <property type="protein sequence ID" value="AYE35606"/>
        <property type="gene ID" value="CP523_14855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60993">
        <property type="protein sequence ID" value="QAS60993"/>
        <property type="gene ID" value="EI377_09810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="166" mass="19065" checksum="FB8365866C452A72" modified="2018-12-05" version="1">MVEKEYDYIRGNTATNPKREYGNPSKDKRVKEKQKIQRQKNKHIQRLKNKRTRGVIQLSAVIFILGVATISRYGQIYKMQHKLTNLKTEIKTEISNGEATRVALLKYSSLEKIREVATGKLGMIAPDNSSTISIDISKNYFPNISEETESKKENKNIFSKLMDALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLJ3</accession>
    <name>A0A386PLJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13225</name>
        <name evidence="2" type="ORF">EI377_08070</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35309">
        <property type="protein sequence ID" value="AYE35309"/>
        <property type="gene ID" value="CP523_13225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60698">
        <property type="protein sequence ID" value="QAS60698"/>
        <property type="gene ID" value="EI377_08070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="90" mass="10332" checksum="E7A7AB6C02F5F798" modified="2018-12-05" version="1">MFTNEDRAVAKIRGYLNVIDNPKWTKEYILKNYGVAVELLIEKATEFKKMNGVKSISEGNQSMTFTDEGKWTITDDIKELLPDPFIKLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLN7</accession>
    <name>A0A386PLN7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">NCS2 family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_13655</name>
        <name evidence="9" type="ORF">EI377_08545</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02091"/>
    <dbReference type="EnsemblBacteria" id="AYE35389">
        <property type="protein sequence ID" value="AYE35389"/>
        <property type="gene ID" value="CP523_13655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60778">
        <property type="protein sequence ID" value="QAS60778"/>
        <property type="gene ID" value="EI377_08545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="437" mass="46247" checksum="F7EE8DE6C46B2684" modified="2018-12-05" version="1">MENTKKNNYLDNYFHLTKSGTNVKREMIAGITTFMTMAYILIVNPSILSAAEMDKGAVFTATAVSAVVSTLIMGLYAKLPFAQAPGMGLNAFFAFTVVLGMGYSFQFALTAVFLEGLIFIVLTIFNVREAVVDSIPNNIKKAISVGIGLFIALIGLEGAGVVVKGEGTLVALGDITKGSALLAIIGIVITGILIARNVKGALFLGMIITAIIGIPMGITPIPTDILSAPPSLSPIFMKFEWHNIFSLDMLVVLFTLLFMDMFDTIGTLVGVATKAKMLDENGKVPNIKKALFADAIGTTLGACLGTSTVSTFVESASGVAEGGRTGLTAVSTAVMFALALFFAPLFGVITPAVTCSALVLVGLFMLEPILEIDLTDWTEAIPAFLTIIMMPLAYSISDGIVFGVISYIIIKLFTGKVKDISITTVIVGIIFILKFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM25</accession>
    <name>A0A386PM25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAD</name>
        <name evidence="2" type="ORF">CP523_15025</name>
        <name evidence="3" type="ORF">EI377_09980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676034.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01279"/>
    <dbReference type="EnsemblBacteria" id="AYE35639">
        <property type="protein sequence ID" value="AYE35639"/>
        <property type="gene ID" value="CP523_15025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61026">
        <property type="protein sequence ID" value="QAS61026"/>
        <property type="gene ID" value="EI377_09980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014211">
        <property type="entry name" value="Spore_III_AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02849">
        <property type="entry name" value="spore_III_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="127" mass="13838" checksum="E0D2EE8589FF46D1" modified="2018-12-05" version="1">MEIIKIVSFAFIGLFLFMIFKDRRSDVAVLISVAVGVTIFLFIAGQLSNVIYFVNDIAEKANIDMIYIGIVLKILAIAYLTSFCSEICKDAGASSIASKVEFSGKILILALAIPILMAVLESILQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAV8</accession>
    <name>A0A386PAV8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pgsA</name>
        <name evidence="18" type="ORF">CP523_00605</name>
        <name evidence="19" type="ORF">EI377_11095</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676356.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00652"/>
    <dbReference type="EnsemblBacteria" id="AYE33055">
        <property type="protein sequence ID" value="AYE33055"/>
        <property type="gene ID" value="CP523_00605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61224">
        <property type="protein sequence ID" value="QAS61224"/>
        <property type="gene ID" value="EI377_11095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00605"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYE33055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QAS61224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="21837" checksum="480DA2B2CA8FA196" modified="2018-12-05" version="1">MNLANKLTMLRIFLVPLFLIFIAVKGIPYGTFIATFIFIVASLTDQLDGYIARRRNQITNFGKFMDPLADKLLVTAALISLVELRVVPSWAAVVIIAREFAVSGLRTIAASEGKVIAASWWGKIKTVTQIIAIIMLLLQVNVGSSIYLSNLAMKNEFFRGLITYAPKYLLLLAIITTILSGYDYFKKNKNIINSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB37</accession>
    <name>A0A386PB37_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage IV sporulation protein A</fullName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Coat morphogenetic protein SpoIVA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIVA</name>
        <name evidence="3" type="ORF">CP523_01010</name>
        <name evidence="4" type="ORF">EI377_11505</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase. Has a role at an early stage in the morphogenesis of the spore coat.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674505.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02317"/>
    <dbReference type="EnsemblBacteria" id="AYE33133">
        <property type="protein sequence ID" value="AYE33133"/>
        <property type="gene ID" value="CP523_01010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61303">
        <property type="protein sequence ID" value="QAS61303"/>
        <property type="gene ID" value="EI377_11505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014201">
        <property type="entry name" value="Spore_IV_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09547">
        <property type="entry name" value="Spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007466">
        <property type="entry name" value="SpoIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02836">
        <property type="entry name" value="spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="492" mass="56074" checksum="5FDA2929755EDF54" modified="2018-12-05" version="1">MDSFNIYKDIAERTQGDIYVGVVGPVRTGKSTFIKKFMDLMVIPKIDNTYKKERAKDELPQSGSGKSIHTTEPKFVPNEAVEITVDEDIKFKIRMVDCVGYIVKGALGYMDGDEAKMVNTPWYDYEIPFEDAAEIGTRKVITDHSTIGLVVTTDGSITGIERDEYLEAEERVINELKSINKPFIIVLNTKNINSPETRQLKKELEEKYNVTVQTMDIANMNEDDIEEILKHVLKEFPVKEINIDMPTWVEKLEPDHWLKKDFFNIVKEMCTNIFRVRDIKKTLSLLKDEEYLGATEITEVSLGEGTARLMMKPKDGIFYKILSEICDLDVESESDLLSLIKELNFAKKEYDKVKDALIDVRETGYGLVAPQLSEMKFEEPEMVKQGTKFGVKLKASAPSLHFIKANIKTEISPIMGSEKESEELVKSLMEQFDKDPSSLWQSNMFGKSLEVLVKEGLQNKLYKMPEDVQVKIQKTLQKIINEGNGGLICIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBH2</accession>
    <name>A0A386PBH2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01800</name>
        <name evidence="3" type="ORF">EI377_12320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02391"/>
    <dbReference type="EnsemblBacteria" id="AYE33283">
        <property type="protein sequence ID" value="AYE33283"/>
        <property type="gene ID" value="CP523_01800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61454">
        <property type="protein sequence ID" value="QAS61454"/>
        <property type="gene ID" value="EI377_12320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="169" mass="18657" checksum="BC6F6BD66BBA734D" modified="2018-12-05" version="1">MEINQLINYFSSYGMIFVFIIVFLEYLNLPGLPAGIILPLIGVLSSKGEGNLALVLIISVIAGAIGSWGLYCVGWFGGDFILNKYTNKFPKHKTYIDKSINVLKEKGNIGVFISMLIPMLRTMISVPAGVLKLNFIQYSIYSTLGIILWNSSLILSGYFFGDAVFKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBR4</accession>
    <name>A0A386PBR4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoVAD</name>
        <name evidence="1" type="ORF">CP523_02345</name>
        <name evidence="2" type="ORF">EI377_12865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673990.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00498"/>
    <dbReference type="EnsemblBacteria" id="AYE33383">
        <property type="protein sequence ID" value="AYE33383"/>
        <property type="gene ID" value="CP523_02345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61554">
        <property type="protein sequence ID" value="QAS61554"/>
        <property type="gene ID" value="EI377_12865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010894">
        <property type="entry name" value="SpoVAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038369">
        <property type="entry name" value="SpoVAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07451">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011570">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02845">
        <property type="entry name" value="spore_V_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="342" mass="36906" checksum="4CF7B5BFE0E8BEC7" modified="2018-12-05" version="1">MNNQNTKKVGKHTVKLSNPPKIIATYSIVGPKEGEGPLKDYFDEILNDDTCGKDSYEKAESDMMHTAIRGVLGRTNLKEEDIDYLFAGDLLNQITSSSFAARQLNIPFFGLYGACSTMAESLSVAAMMMDGGFANHVIASTSSHFSAAERQFRFPLEYGCQRCATCQWTVTGSGAMLLAKDGNFPEITYVTTGVVKDYGIKDANNMGAAMAPAAVDTLVRHFKDTGRQPGFYDVIATGDLGKVGKEITNKLMMEYGYDIRENYVDCGDMIFDDVVQNTDAGGSGCGCSAVVASGCFYKKLMRKEIKSVLLVSTGALMSTTSSLQGETIPGIAHAVAIEYKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC46</accession>
    <name>A0A386PC46_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-L-AF_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01757"/>
    <dbReference type="EnsemblBacteria" id="AYE33523">
        <property type="protein sequence ID" value="AYE33523"/>
        <property type="gene ID" value="CP523_03095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-AF_C" evidence="5">
        <location>
            <begin position="41"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="437" mass="48311" checksum="EBF052B589A7160E" modified="2018-12-05" version="1">MKFNTAFTNKHCLIDFPGGDVLGPGKQALIQSIKQPDGSYRFYGTPSLKVFSILNNMIANDLIETKIINNKKFYNNVDTIHAMTSKDKDSIYVLLINMDREENVKVKIDVNNSEIKDNKAEVMTLSGNGVYDVNSLEEPNKVDVVKSEVIIDPDNVEYEVPAHSVVGIKLSTNGEEVDKSALKEVIDYAEKLKSEGALEGVSPTVLEKFNKALEKANSVIADENTTQKEVDEALKGLQEVIGKLEISNVNKEVLQELVDKINGLNKYEYITSTWEVLEAELKNALNVLTNKEATQSEVDLAHNNLNKAYLNLILIPDKSKLEELINKAEGIDATKCTVDSYKTLEEALIKAREIFNDKNATLEQVNKSQKELEGALKVLVKNSNNDIVQDESNKGNNSNNINKGSLPETGKTPAVAVGLFGLLISSIGLDLLIRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC66</accession>
    <name>A0A386PC66_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YqfC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqfC</name>
        <name evidence="1" type="ORF">CP523_02220</name>
        <name evidence="2" type="ORF">EI377_12740</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674033.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00523"/>
    <dbReference type="EnsemblBacteria" id="AYE33360">
        <property type="protein sequence ID" value="AYE33360"/>
        <property type="gene ID" value="CP523_02220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61530">
        <property type="protein sequence ID" value="QAS61530"/>
        <property type="gene ID" value="EI377_12740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022477">
        <property type="entry name" value="Spore_YqfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02856">
        <property type="entry name" value="spore_yqfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="10312" checksum="033CE231CB1DCA5C" modified="2018-12-05" version="1">MQDKLNKSRNIIVEKLDLPKDIILDIPRITVLGDGEITIENHKGIVVFERNIIKVNTNVSPITINGENFEILYIGSSTITISGKFQSIIYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCB3</accession>
    <name>A0A386PCB3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rsgA</name>
        <name evidence="10" type="ORF">CP523_00925</name>
        <name evidence="11" type="ORF">EI377_11420</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674546.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02334"/>
    <dbReference type="EnsemblBacteria" id="AYE33117">
        <property type="protein sequence ID" value="AYE33117"/>
        <property type="gene ID" value="CP523_00925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61287">
        <property type="protein sequence ID" value="QAS61287"/>
        <property type="gene ID" value="EI377_11420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="61"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="70"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="161"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="33192" checksum="2C66ABFCA9630872" modified="2018-12-05" version="1">MKGKIIKGIGGFYYIKTEKGLIECKARGKFRHRDMKPIVGDNVIINVENGKGVIEDILERSSELIRPTIANVTQAFVVFAIKNPDINFDLLNRFLILCEHNNIKSIVCLNKVDLVSNEEREEIRKKINDIGYEVLYINAKKGEGIESLKEKLRGNETVLCGPSGAGKSTLINKLINRDHMETGKVSDKIGRGKHTTRHSELIEISDGYLVDTPGFSTLEVNFIDKEELRYCFPEFEEYNHNCKFRGCLHNKEPKCSVKQAVQEGKINEYRYKFYIRTLEEIMDGRNNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCB9</accession>
    <name>A0A386PCB9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4046 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677929.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33603">
        <property type="protein sequence ID" value="AYE33603"/>
        <property type="gene ID" value="CP523_03535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025119">
        <property type="entry name" value="DUF4046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13255">
        <property type="entry name" value="DUF4046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4046" evidence="1">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="247" mass="29558" checksum="0B5792346F468893" modified="2018-12-05" version="1">MKQINSRINDMDTLKIYRLILEGSVEKFPRGFWKRPEAKQDAAILTRYLIENILMWSDEELKENLRFIVLKKYKLSGMVEKVFNYSIFNLVDNAYPGKFKPWELSKVENNYWNEETCREALKWLFEEKLKWGLEDIKENLTGEVFIENKLNGMFSKIFNGSPYEVVNFIYPNKIKPWELKQVPNNYWNDNTTKEAINWLLKEKVDFNNRKKISRKVFVENRLDGMIQKMFSGSVKRANVKIKLDTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCT1</accession>
    <name>A0A386PCT1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02387"/>
    <dbReference type="EnsemblBacteria" id="AYE33287">
        <property type="protein sequence ID" value="AYE33287"/>
        <property type="gene ID" value="CP523_01820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="312" mass="34729" checksum="9A8BA985B35A8294" modified="2018-12-05" version="1">MGLIIGVVMLVFLLLLILSSIKIVNTGYLYVVERFGQYHRILEPGWHFLIPFVDFVRKKVSTKQQILDVPPQSVITKDNVKISVDNVIFYKLLNARDAVYNIEDFKSGIVYSATTNMRNIIGNMSLDEVLSGRDKINQDLLSIIDEVTDAYGIKILSVEIKNIIPPAEIQEAMEKQMKAERDKRAMILQAEGQRQSQIEKAEGEKQSQILRAEAEKQANIRRAEGLKESQLLEAEGKAKAIAKIAEADAEAIRKVNEAIIQSGTNETVIALKQVEALKEMANNPANKLILPNETLSSLGSIAAIGEMLKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCV9</accession>
    <name>A0A386PCV9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33813">
        <property type="protein sequence ID" value="AYE33813"/>
        <property type="gene ID" value="CP523_04660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017329491" evidence="2">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="206" mass="23367" checksum="24480014C37DB990" modified="2018-12-05" version="1">MFLKKAIVVKVIILALVCVGCTSNDINKTSYTKDPNKSDIELKDENSELEDDEKSNLDESMIKSDDGKKGTVEVINEDTNEITTEAEVEVMDLIPDKDFFFPDLEQLPSDIKEWVLANKDKKKEISAYVKTTANATYVLASVTNDTGGKIAMIHTPYMISDSDEWVVPYSFMLRDKWIDSNGNEYLIMQTSKPVKVRLEHATIYEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD13</accession>
    <name>A0A386PD13_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04985</name>
        <name evidence="5" type="ORF">EI377_15485</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33875">
        <property type="protein sequence ID" value="AYE33875"/>
        <property type="gene ID" value="CP523_04985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62017">
        <property type="protein sequence ID" value="QAS62017"/>
        <property type="gene ID" value="EI377_15485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362907" evidence="3">
        <location>
            <begin position="22"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="308" mass="34601" checksum="DDDD506806BAD007" modified="2018-12-05" version="1">MKKILTLMVMFLTISTIWVYAETNTDINFNIDGEVSKGKEVTININVDKADRLYGLSVDYTYNPEEIKVTSIQGAGLIKESKDNFFEAGGETAKDGNIANYQMTFTGEVDGISGSGTLVTIKAEVLKDTNLNLTEDNMKIKLIGINKDYKVSRMDFNLKEVKEDKKEETKEESKEENTEDSSKPKEENKNYKVDKASDNELKEDKPTIVKKILKFFGVNNTNTQLQEEKNDNIKEENSKKDTSDESKKESKDNTEDKNVDTKKQDKDKENNKNTSSMLPVGVGGAVIVLVAAIVIFKLKNKKGNKGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD20</accession>
    <name>A0A386PD20_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiC</name>
        <name evidence="6" type="ORF">CP523_01485</name>
        <name evidence="7" type="ORF">EI377_12005</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675627.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00849"/>
    <dbReference type="EnsemblBacteria" id="AYE33224">
        <property type="protein sequence ID" value="AYE33224"/>
        <property type="gene ID" value="CP523_01485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61396">
        <property type="protein sequence ID" value="QAS61396"/>
        <property type="gene ID" value="EI377_12005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01485"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="207" mass="22985" checksum="771C436D3A62DA5F" modified="2018-12-05" version="1">MSYIKNPMEIEETSFEIIGDEMGNHDFTEDELKVVKRVIHTTADFEYMELIEISKDAINVGKEILKNNPIIYTDTNMALSGINKKALEKLNGKVICYVNLEEVHKEAKEKGITRSMAAVEKASADSVDIFVFGNAPTALFKLKELIKEKKANPKLIIAVPVGFVGASESKENLEELNIPYITVKGRKGGSTVAASIINALMYMVVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD61</accession>
    <name>A0A386PD61_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_02535</name>
        <name evidence="16" type="ORF">EI377_13070</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673935.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00460"/>
    <dbReference type="EnsemblBacteria" id="AYE33417">
        <property type="protein sequence ID" value="AYE33417"/>
        <property type="gene ID" value="CP523_02535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61591">
        <property type="protein sequence ID" value="QAS61591"/>
        <property type="gene ID" value="EI377_13070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006136">
        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00328">
        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="13" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0969">Cilium</keyword>
    <keyword evidence="15" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="616" mass="68484" checksum="360B8A98D85B4EDC" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD74</accession>
    <name>A0A386PD74_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678958.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00304"/>
    <dbReference type="EnsemblBacteria" id="AYE32951">
        <property type="protein sequence ID" value="AYE32951"/>
        <property type="gene ID" value="CP523_00045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="290" mass="31331" checksum="BB66E2BE548FFE40" modified="2018-12-05" version="1">MSFEKILKIKIPGQHQDKQPGEESLMNPAPIYTLLNYTYPSGRLKDKVAIITGGDSGIGKAVALAYAKEGAKVAIVYLNEHDDAKKTKSLIEENGGKCILISGDIGEESFCKKVVDEVIQNFKTINILVNNSGEQHTANSIEDITAKQLERTFKTNFFGAFYLSKAVIPHLKQGDSIINTTSVTAYQGNETLIDYSSSKGALTSFTRSLAKNLATNGIRVNAVAPGPIWTPLIPSSFDNNRVSTFGENTAMKRAGQPVELAESYVFLASNGSSYITGETIHVNGGDMVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDC7</accession>
    <name>A0A386PDC7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mor transcription activator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33995">
        <property type="protein sequence ID" value="AYE33995"/>
        <property type="gene ID" value="CP523_05695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014875">
        <property type="entry name" value="Mor_transcription_activator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08765">
        <property type="entry name" value="Mor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mor" evidence="1">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="99" mass="11465" checksum="369139292D14958C" modified="2018-12-05" version="1">MSIDKSDFNGIYEELIELLGLEVTIKIHEYFKGQQVNFPIKLHSKAYVMKELQGKSVGDSKELAKKLGYTENWIRKLLKKIERGNDNEGDSRKFQSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDL0</accession>
    <name>A0A386PDL0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">[FeFe] hydrogenase H-cluster radical SAM maturase HydE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hydE</name>
        <name evidence="6" type="ORF">CP523_03275</name>
        <name evidence="7" type="ORF">EI377_13790</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02129"/>
    <dbReference type="EnsemblBacteria" id="AYE33557">
        <property type="protein sequence ID" value="AYE33557"/>
        <property type="gene ID" value="CP523_03275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61720">
        <property type="protein sequence ID" value="QAS61720"/>
        <property type="gene ID" value="EI377_13790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024021">
        <property type="entry name" value="FeFe-hyd_HydE_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034422">
        <property type="entry name" value="HydE/PylB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43726">
        <property type="entry name" value="PTHR43726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00348">
        <property type="entry name" value="FeFe_hydrogenase_maturase_(Hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03956">
        <property type="entry name" value="rSAM_HydE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="55"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="376" mass="42781" checksum="9D037370D374B6E6" modified="2018-12-05" version="1">MGVINIKVKLIIDKIYKENNATRDELLFLLNNLNDKDKEYLIEKAHETRMRTYGDKVYMRGLIEFTNFCKKDCIYCGIRRSNKKADRYRLTYEDIMECADIGDKLGYKTYVLQGGEDAYFTDEKMIEIIKGIKEKYPNNAITLSLGERSYESYKKMFEAGADRYLLRHETATKELYESLHPGASFENRRKCLKDLKKIGYQIGAGFMVEIPNQTNEDLVNDLIFVKELEPHMCGIGPFIPHKDTPLKNEVAGTVEKTTTMLALIRLLLPNVLLPSTTALGSIDPNGREKGIKAGGNVVMPNLSPTRVREKYSLYDGKICTGDEAAECRMCIEGRIKKAGFRVEVTRGDNILWAKSNNVNKGTGNKVKVENIRINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDX6</accession>
    <name>A0A386PDX6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2508 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF2508 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07030</name>
        <name evidence="2" type="ORF">EI377_01775</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673680.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34225">
        <property type="protein sequence ID" value="AYE34225"/>
        <property type="gene ID" value="CP523_07030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59630">
        <property type="protein sequence ID" value="QAS59630"/>
        <property type="gene ID" value="EI377_01775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019644">
        <property type="entry name" value="DUF2508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10704">
        <property type="entry name" value="DUF2508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="81" mass="9574" checksum="5893B2999491E865" modified="2018-12-05" version="1">MNKGIIMDLLMQKVDYSKEDQEIIDNIENARMEMEVAREMFNAVSDPKLIELAIHAEDVAKMRYDYLISIAKKREIRRNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDY4</accession>
    <name>A0A386PDY4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01520</name>
        <name evidence="4" type="ORF">EI377_12040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675647.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PDY4"/>
    <dbReference type="STRING" id="1504.GCA_900092375_00856"/>
    <dbReference type="EnsemblBacteria" id="AYE33231">
        <property type="protein sequence ID" value="AYE33231"/>
        <property type="gene ID" value="CP523_01520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61403">
        <property type="protein sequence ID" value="QAS61403"/>
        <property type="gene ID" value="EI377_12040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="73" mass="8001" checksum="451284595E77D16A" modified="2018-12-05" version="1">MNTLDNIGIGVEVKVKGLEKESLVRRRLLDMGITPGVTVKVTGKAPMGDPIEILIRGYKLTLRKNEAKAVIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE08</accession>
    <name>A0A386PE08_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04030</name>
        <name evidence="3" type="ORF">EI377_14550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676921.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02780"/>
    <dbReference type="EnsemblBacteria" id="AYE33697">
        <property type="protein sequence ID" value="AYE33697"/>
        <property type="gene ID" value="CP523_04030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61852">
        <property type="protein sequence ID" value="QAS61852"/>
        <property type="gene ID" value="EI377_14550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="313" mass="35559" checksum="2505D69901C503D5" modified="2018-12-05" version="1">MQNKNPNSLFGIDINEFTQGADFATLARTIDFLYLRSSGSGSGRFRVDKKFLEFARLSREYGIPVGAYHFGVPSYDLTTADSQCDDFIGILQDGFGNKNYGDLFPVLDVEAPTDKTISTKALIDWIDRFRKRFEKKTRRRLMLYTGLFFIDLYNNFTLPGGAQPLKNMPLWIAMYTKVPSNPAYPPDAGGWTKWRIWQYSEDQKVNGVQNPVDANWGPDNIALLMQPMNVRNFKAVKVGNNIKISWRKNTDVDLLGYNLFANGYWIGTVDKTDTNFEVSTRNLPFTPKGPITISIEAFDYDGETSPQRSKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE26</accession>
    <name>A0A386PE26_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pknB</name>
        <name evidence="11" type="ORF">CP523_00930</name>
        <name evidence="12" type="ORF">EI377_11425</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674544.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02333"/>
    <dbReference type="EnsemblBacteria" id="AYE33118">
        <property type="protein sequence ID" value="AYE33118"/>
        <property type="gene ID" value="CP523_00930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61288">
        <property type="protein sequence ID" value="QAS61288"/>
        <property type="gene ID" value="EI377_11425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="445"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="513"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="638"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="667" mass="74444" checksum="7288A33CE4DDFE9A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE36</accession>
    <name>A0A386PE36_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein CP523_00985</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00985</name>
        <name evidence="3" type="ORF">EI377_11480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008678315.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02322"/>
    <dbReference type="EnsemblBacteria" id="AYE33128">
        <property type="protein sequence ID" value="AYE33128"/>
        <property type="gene ID" value="CP523_00985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61298">
        <property type="protein sequence ID" value="QAS61298"/>
        <property type="gene ID" value="EI377_11480"/>
    </dbReference>
    <dbReference type="GeneID" id="66301519"/>
    <dbReference type="KEGG" id="csep:CP523_00985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="9720" checksum="B7DB791BF4BB031C" modified="2018-12-05" version="1">MGIKLINIGFGNIVSANRLVAIVSPESAPIKRIIQEARDRGMLIDATYGRRTRAVIITDSDHVILSAVQPETVAHRLVAKDEAVDEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE58</accession>
    <name>A0A386PE58_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pili twitching motility protein PilT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Type IV pilus twitching motility protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01095</name>
        <name evidence="4" type="ORF">EI377_11595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674448.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02299"/>
    <dbReference type="EnsemblBacteria" id="AYE33148">
        <property type="protein sequence ID" value="AYE33148"/>
        <property type="gene ID" value="CP523_01095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61318">
        <property type="protein sequence ID" value="QAS61318"/>
        <property type="gene ID" value="EI377_11595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="351" mass="38973" checksum="8E2AD3BAA216788A" modified="2018-12-05" version="1">MYILRDLLSKTIEAEASDLHLTVGVPPIIRNNGRLIKLGTNKLTPEDIEAFAKEILQAKYEEYNKIGELDISYSVPGVGRFRVNVFKQRNSDAIAIRVIALKIPTLDELKHPAVIKELVQKQRGLVLVTGPAGSGKSTTLAAMINEINSTREAHIITLEDPIEYLHKHNKCIINQREIGKDSSSYKSALKAILREDPDVILVGEMRDLETISIALTAAETGHLVFSTLHTIGAAKTIDRIIDVFPPHQQQQVRVQLSAMLKGVISQQLVPNADNTGRVVALETMITTPGIQNLIREGKTYQIESAIQTGSKYGMKTMDMSLAELYRRGTISIETAFSHSVDRETIKRIMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE76</accession>
    <name>A0A386PE76_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01200</name>
        <name evidence="3" type="ORF">EI377_11700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33168">
        <property type="protein sequence ID" value="AYE33168"/>
        <property type="gene ID" value="CP523_01200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61338">
        <property type="protein sequence ID" value="QAS61338"/>
        <property type="gene ID" value="EI377_11700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363034" evidence="1">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="161" mass="18586" checksum="F16E736CFD179291" modified="2018-12-05" version="1">MKRMVIKTVGVLMIISLLFTGCTSIVSNSENKKIKETIDLVLSYDKGYDDTVSKYISKVNFNIVNYVSFYSTYLGDASLEKYESTIRSIKKENEKYRVCMVLNMVAKAKEVHGHEEERDEAEGENVPVEIVLTKNSNKYYIESFKEYESLDKAIENNKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEG5</accession>
    <name>A0A386PEG5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_06880</name>
        <name evidence="12" type="ORF">EI377_01365</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679174.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00041"/>
    <dbReference type="EnsemblBacteria" id="AYE34200">
        <property type="protein sequence ID" value="AYE34200"/>
        <property type="gene ID" value="CP523_06880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59565">
        <property type="protein sequence ID" value="QAS59565"/>
        <property type="gene ID" value="EI377_01365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="811" mass="93511" checksum="E8F3775EF3A1359B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI1</accession>
    <name>A0A386PEI1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33441">
        <property type="protein sequence ID" value="AYE33441"/>
        <property type="gene ID" value="CP523_02660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="299"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="385" mass="41727" checksum="9AD9992A2727670B" modified="2018-12-05" version="1">MIINHNMNAMNAHRNMASNTVATGKSMEKLSSGLRINRAGDDAAGLSISEKMRGQIRGLEQASRNSQDGISLIQTTEGALNETHSILQRMRELSVQASNDTNTAEDRGQLTKELDQLRSEIDRISSQTQFNKMDVLNGDGDKSFKANIQVGANSNQAIEIAIDKMDYSSLFKAHKVASTDEVAGDITVKATKDIKVTIDGKDITIAADKAKDKVMTKEELVSAINKGIEAEATLKGKVSASFEDNKLTISRIDGVDKEVTVKVESDGTNTKLGLGTDAKSKMEVFNVDLTSHAAATGSISAIDRAIEKVSTQRSQLGAYQNRLEHTIKNVDNAAENLQAAESRVRDVDMANEMMTFSKNNILTQAAQAMLAQANQQPQGVLQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEI5</accession>
    <name>A0A386PEI5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_07005</name>
        <name evidence="6" type="ORF">EI377_01750</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01017"/>
    <dbReference type="EnsemblBacteria" id="AYE34220">
        <property type="protein sequence ID" value="AYE34220"/>
        <property type="gene ID" value="CP523_07005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59625">
        <property type="protein sequence ID" value="QAS59625"/>
        <property type="gene ID" value="EI377_01750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="27"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="107"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="304" mass="33711" checksum="88F9733C2B415C31" modified="2018-12-05" version="1">MYKVLASDGLEKSAIDNLVSFGFYVENNHYSDDVLIKRIKDFDVLIVRSATKVRKNILDEAIKGNLKLIIRAGVGTDNIDVDYACSKGVSVGNTPNSSSNAVAELVLGHMFALTRFIGISNYTMRNGQWNKKKYKGVELNDKTLGIIGMGRIGRSLAKKAEVLGMKVQYYTIEEKHKDLNYDFLSLEEVLKTSDFISLHVPYEKEKGALIGKRELNIIKDGAYIINCARGKVIDEEALLESLNSGKIAGAGIDVFEEEPTKNKDLVSHQNVSCTPHIGAATKEAQERIGEEVVSIIKDFFKIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP9</accession>
    <name>A0A386PEP9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GlcN6P deaminase</fullName>
            <shortName evidence="2">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">nagB</name>
        <name evidence="4" type="ORF">CP523_08825</name>
        <name evidence="5" type="ORF">EI377_03580</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678099.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02705"/>
    <dbReference type="EnsemblBacteria" id="AYE34513">
        <property type="protein sequence ID" value="AYE34513"/>
        <property type="gene ID" value="CP523_08825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59915">
        <property type="protein sequence ID" value="QAS59915"/>
        <property type="gene ID" value="EI377_03580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08825"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="3">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="243" mass="26699" checksum="5969D445D0DA50E5" modified="2018-12-05" version="1">MKLIVTKNYEELSKVAAKEMADIIKSNPKAVLGLATGGSPIGMYKELIRMNKESEIDFSQITTVNLDEYVGLSGEHNQSYRYFMNENLFNHININKENTFVPNGLAENIEEECQNYDKKIAELGGTDVQLLGIGNNGHIAFNEPDNFLVAGTHLTNLTQNTIEANARFFDSIDEVPTTALTMGLGGIMKSKKIIVIASGKGKAEAVKEMLSGKINTNMPASMLQMHKDVILIIDEDAASLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES4</accession>
    <name>A0A386PES4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4358 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00210</name>
        <name evidence="3" type="ORF">EI377_10680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677385.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32982">
        <property type="protein sequence ID" value="AYE32982"/>
        <property type="gene ID" value="CP523_00210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61150">
        <property type="protein sequence ID" value="QAS61150"/>
        <property type="gene ID" value="EI377_10680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025648">
        <property type="entry name" value="DUF4358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14270">
        <property type="entry name" value="DUF4358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788307" evidence="1">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="159" mass="17792" checksum="518773B5B544F8EC" modified="2018-12-05" version="1">MKKLVGILLSLFTFGAIFVGCSSSSSGNELKDNLTLKNVVEKIEEVAPMQMPMEADEEMAKNIYHLNLDDVEEYYIKSAMVMNSADNTVIVKAKDSKVDNVKKSLETRLTDVQKSFEQYLPDQKEKANKGKILTKGNYVILLINDDIKSAENAVNSCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX8</accession>
    <name>A0A386PEX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05640</name>
        <name evidence="2" type="ORF">EI377_00070</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33987">
        <property type="protein sequence ID" value="AYE33987"/>
        <property type="gene ID" value="CP523_05640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59350">
        <property type="protein sequence ID" value="QAS59350"/>
        <property type="gene ID" value="EI377_00070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="56" mass="6248" checksum="4AC8620AA9853BFA" modified="2018-12-05" version="1">MIMEAHMNKKLVPNTKGCYRGVANNGMTIEMYLYRNVDGSNIADIITAYPVHSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ1</accession>
    <name>A0A386PEZ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33814">
        <property type="protein sequence ID" value="AYE33814"/>
        <property type="gene ID" value="CP523_04665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="142" mass="16439" checksum="ECBB09174371929C" modified="2018-12-05" version="1">MRYIKYLFNYYNKEYLIKSYLVALFMAFLYISGILEADKVNVLISVEGMKYIIIAISFTILYPFSKGTYLSIKESLLSDIPIIFANIVVIFIAKLFMAMILWGFSVPLGIVNLIIIYTKYRKNTVKIIKKDITADIEGFKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF59</accession>
    <name>A0A386PF59_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rnr</name>
        <name evidence="9" type="ORF">CP523_03845</name>
        <name evidence="10" type="ORF">EI377_14380</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675496.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01541"/>
    <dbReference type="EnsemblBacteria" id="AYE33661">
        <property type="protein sequence ID" value="AYE33661"/>
        <property type="gene ID" value="CP523_03845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61823">
        <property type="protein sequence ID" value="QAS61823"/>
        <property type="gene ID" value="EI377_14380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03845"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="623"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="741" mass="86008" checksum="B7D6F69CCABE148C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF65</accession>
    <name>A0A386PF65_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06125</name>
        <name evidence="4" type="ORF">EI377_00595</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01925"/>
    <dbReference type="EnsemblBacteria" id="AYE34077">
        <property type="protein sequence ID" value="AYE34077"/>
        <property type="gene ID" value="CP523_06125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59446">
        <property type="protein sequence ID" value="QAS59446"/>
        <property type="gene ID" value="EI377_00595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362705" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="76"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="334" mass="36965" checksum="720F2CC7C7E1BC5E" modified="2018-12-05" version="1">MAKQKLISTKMKVFMLCLFAGSIISFSAAGVLLYNSDFTLANYFDVNDWNLNFFSNSSRLQGHESYLTNQDLNEIENLSIDFNGYNVYFETYEGNTLDLYLYDNFNRSSNSRNATSSNTVESPFSISREGNKLTVKPNTNILTELASHYEFMIKIPYSYNKGLSINSSSGEMKLDNLKLSNMNLKAINSTINLNSVSCESANISLTNGNIHGDSFSSKNLIASTVNGNLYFSPLSGEVKLTTVNGNIHSTITSYLTNLDINTTSGYVNLNIPDEGDFSFNYSTMNGEFLSELNNPNGSYLDIPTKVQGSTDFSTGNGTNKINVKTVSGNFKIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA0</accession>
    <name>A0A386PFA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic sulfite reductase subunit AsrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677244.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02138"/>
    <dbReference type="EnsemblBacteria" id="AYE33548">
        <property type="protein sequence ID" value="AYE33548"/>
        <property type="gene ID" value="CP523_03225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014259">
        <property type="entry name" value="Sulphite_reductase_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02910">
        <property type="entry name" value="sulfite_red_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="335" mass="39121" checksum="DB95DAAECC4B46C6" modified="2018-12-05" version="1">MGYKLNLENLNIALRELSKEYKIYAPKVLEGKGTFSDTDIVRYGEISKVEEIEFEKKSQFSYKEVILPITQTLFFFTEDEVKEASIEEKSLLIFLRSCDIHSLKRIDDIYLRNGFVDPYYEKLREKAKFVLIGCNKSFENCFCVNMGTNKTDEYDAYLKLDGQDAYIDLKDEKLEASFTNVDVEKLEVKPEFVSENEVKVNIPNNLELKVMDSKMWDEYSQRCIACGRCNFVCPTCTCFTMQDIFYKDNGKAGERRRVWASCQVDGYTDMAGGHSFRKAKGQRMRYKVLHKVYDYKKRWGYHMCVGCGRCDDICPEYISFSNCINKLENAMEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE5</accession>
    <name>A0A386PFE5_CLOSE</name>
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        <submittedName>
            <fullName evidence="13">DUF1533 domain-containing protein</fullName>
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        <name evidence="13" type="ORF">EI377_05095</name>
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    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Cell wall</location>
            <topology evidence="1">Peptidoglycan-anchor</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="QAS60162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01432"/>
    <dbReference type="EnsemblBacteria" id="AYE34763">
        <property type="protein sequence ID" value="AYE34763"/>
        <property type="gene ID" value="CP523_10315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60162">
        <property type="protein sequence ID" value="QAS60162"/>
        <property type="gene ID" value="EI377_05095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10315"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011432">
        <property type="entry name" value="DUF1533"/>
    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NEAT_dom"/>
    </dbReference>
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        <property type="entry name" value="NEAT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07550">
        <property type="entry name" value="DUF1533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0964">Secreted</keyword>
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    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362940" evidence="9">
        <location>
            <begin position="33"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1122"/>
        </location>
    </feature>
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        <location>
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            <end position="364"/>
        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="1090"/>
        </location>
    </feature>
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        <location>
            <begin position="1096"/>
            <end position="1128"/>
        </location>
    </feature>
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        <location>
            <begin position="175"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="908"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
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            <begin position="920"/>
            <end position="951"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1128" mass="127163" checksum="09CF4031575FEAA6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG5</accession>
    <name>A0A386PFG5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10495</name>
        <name evidence="4" type="ORF">EI377_05280</name>
    </gene>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 7534</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 6">VAT12</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="376" mass="43513" checksum="6591646C3C045884" modified="2018-12-05" version="1">MKEVKILQCGDLHFDTPFKELSNSLALVSKEELLEVFKRIIDICEKEYIDIFLLSGDIFDNFTVNKKTLNFIKSQLQRISNIRIFISPGNHDPYNEKSFYKMIEWPKNVHIFKGKLENIFIEELETVVWGAAFNSQYVKKSLIEGVQIKNDYINIALIHGDISNVEEGNEYNPITLKEIGESNIDYIALGHRHTYSGILRERNTCYAYSGCPQGRGFDELGDKGVIIGSISKGAVDLKFIKTSKRNYYVEEIDITNSIGYEEIKSVILDSIDRDKRESNLYKIILTGELDDSFNLREEIVLDKIKDDFYFVKVIDKTEIKVDYSEISKDFSVKGLFVKKLLEKLEQSNDEESEIIKMSLKLGMQCLSEEEVRRDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH9</accession>
    <name>A0A386PFH9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor domain-containing diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04420</name>
        <name evidence="4" type="ORF">EI377_14965</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00394"/>
    <dbReference type="EnsemblBacteria" id="AYE33771">
        <property type="protein sequence ID" value="AYE33771"/>
        <property type="gene ID" value="CP523_04420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61929">
        <property type="protein sequence ID" value="QAS61929"/>
        <property type="gene ID" value="EI377_14965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="221"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="672" mass="77956" checksum="B11F07831CA9520B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI7</accession>
    <name>A0A386PFI7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">CP523_09070</name>
        <name evidence="11" type="ORF">EI377_03815</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678371.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00253"/>
    <dbReference type="EnsemblBacteria" id="AYE34560">
        <property type="protein sequence ID" value="AYE34560"/>
        <property type="gene ID" value="CP523_09070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59960">
        <property type="protein sequence ID" value="QAS59960"/>
        <property type="gene ID" value="EI377_03815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="146" mass="15566" checksum="126F8099ABAE125A" modified="2018-12-05" version="1">MKLHELKPAAGSKKAPKRVGRGTGSGLGRNAGKGEKGQNARSGGGVRPGFEGGQMPLYRRLPKRGFTNIFAKKYVSINVDRLNIFENGTEVTPEVLLERRVVSKVMDGVKILGNGTIEKSLTVKGCKFSKSAAEKIEAAGGKVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS9</accession>
    <name>A0A386PFS9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Formate C-acetyltransferase/glycerol dehydratase family glycyl radical enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glycyl radical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00475</name>
        <name evidence="6" type="ORF">EI377_10965</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676306.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00624"/>
    <dbReference type="EnsemblBacteria" id="AYE33029">
        <property type="protein sequence ID" value="AYE33029"/>
        <property type="gene ID" value="CP523_00475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61198">
        <property type="protein sequence ID" value="QAS61198"/>
        <property type="gene ID" value="EI377_10965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010098">
        <property type="entry name" value="PFL2/GDeHydtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01774">
        <property type="entry name" value="PFL2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="13"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="683"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="803" mass="90492" checksum="BE156ED7E4AA1396" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU9</accession>
    <name>A0A386PFU9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11150</name>
        <name evidence="9" type="ORF">EI377_05940</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00910"/>
    <dbReference type="EnsemblBacteria" id="AYE34923">
        <property type="protein sequence ID" value="AYE34923"/>
        <property type="gene ID" value="CP523_11150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60317">
        <property type="protein sequence ID" value="QAS60317"/>
        <property type="gene ID" value="EI377_05940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008358">
        <property type="entry name" value="Sig_transdc_His_kin/Pase_MprB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01780">
        <property type="entry name" value="LANTIREGPROT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="90"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="299" mass="34514" checksum="A06CA11927B4932F" modified="2018-12-05" version="1">MIQNIIIGGLLVLLCIAITLLFLTNNKIKSITINLKEVNEVDTNKGIRILAFNKNLNILIKEVNELIRKNKEMQYRYKEADLEIRQAIANMSHDLRTPLTSVMGYIQLLENENISSDEKKQYISIIEKRSQSLKSLISSFYDLSRLQASEYEMNIEKINISSILCNIIASFYDDFENNNLNPIIKIDENSGVVNGDKNATERIFINIIQNILKHAKGDLEIYLSKSDKYIITQFINDAPDLKEEDVKRIFERFFTSDRMRTGRNTGLGLAITKILVEKQGHEIWAEKLKGKLIINIKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV7</accession>
    <name>A0A386PFV7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677791.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34124">
        <property type="protein sequence ID" value="AYE34124"/>
        <property type="gene ID" value="CP523_06385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017283731" evidence="2">
        <location>
            <begin position="31"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="297" mass="32798" checksum="3E3AEDE846CD8DA6" modified="2018-12-05" version="1">MNKKLFLKLLLLLLLSMSLVACRQKNNSAGEDTSSKSSTSNVQSSVKESVKTASSSAENTVESKQEDKDTSSDVKKNSNASKANDAPEQFIMAGGANKVPGLCEYIVSPEINPSIITQNPLFNDSVNNDINYIDVVLNIFNTSNEAKMSKDAITAKIKIKDKEYSSFSLIENIDGSNFDEATSVNPQETRMIHYIAKVPKFEAGLTNYEIILTIKGKDYSNKFIHEQGLTEEEYYKLIKEAKQLQQDYIDSISDPHVKQSVQSPLGAAVAESSSLYLQYPKDIDTIDAALKRVLNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY4</accession>
    <name>A0A386PFY4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03445</name>
        <name evidence="8" type="ORF">EI377_13970</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677895.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02240"/>
    <dbReference type="EnsemblBacteria" id="AYE33586">
        <property type="protein sequence ID" value="AYE33586"/>
        <property type="gene ID" value="CP523_03445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61750">
        <property type="protein sequence ID" value="QAS61750"/>
        <property type="gene ID" value="EI377_13970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="33629" checksum="D9707B7ADA39142B" modified="2018-12-05" version="1">MWDIMQQVFPNAIAFTIPLLIVALGALFCERSGIVNVGLDGLMIIGSFAGAFTIVKLQEKMPGSSLPLWIGLLVAMIIGMLFSLLHAFASINLNANQVISGTAINMIAGSLTIFLARTITGSGNIRIIKGFIPQDVPVLSKIPILGDLFFSDSYITTWLVLVILIISIFILYKTSFGLRLRACGEHPQAADAAGINVYKMRYIGVMISGAFSALGGVIILVTYSGEFNGSVAGLGFLALAALIFGQWRPLGILGATLFFGTAVTVANISQVTPELAAVPQVILKVFPYAITLLALVLFSKSSQAPKAAGEPFDSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG89</accession>
    <name>A0A386PG89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroorotate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Undecaprenyl diphosphate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03245</name>
        <name evidence="3" type="ORF">EI377_13760</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677236.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02134"/>
    <dbReference type="EnsemblBacteria" id="AYE33552">
        <property type="protein sequence ID" value="AYE33552"/>
        <property type="gene ID" value="CP523_03245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61715">
        <property type="protein sequence ID" value="QAS61715"/>
        <property type="gene ID" value="EI377_13760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="24445" checksum="851AF2CDD9CCAC01" modified="2018-12-05" version="1">MRVPKHIGIIPDGNRRFAVSKGLTKDKGYSLGIDPGLILFKLCQKEGIDEITYYGFTTDNTKRPSDQKEAFIDACIKAVNLLTHEDCEILVIGNTESHVFPKELSEFTTRKTFGKGGTKVNFLINYGWEWDLNSLKSADIKKRNITRNLKSNDISRIDLIIRWGGRRRLSGFLPVQSVYSDFYVVDDLWPDFKPQHFYDALDWYNKQDITLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE0</accession>
    <name>A0A386PGE0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA</name>
        <name evidence="7" type="ORF">CP523_04180</name>
        <name evidence="8" type="ORF">EI377_14705</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676857.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02749"/>
    <dbReference type="EnsemblBacteria" id="AYE33726">
        <property type="protein sequence ID" value="AYE33726"/>
        <property type="gene ID" value="CP523_04180"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61883">
        <property type="protein sequence ID" value="QAS61883"/>
        <property type="gene ID" value="EI377_14705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="11800" checksum="2EFEA978EFB8A393" modified="2018-12-05" version="1">MVKHINEQEFDLEVLKEKGVVVVDFFATWCGPCKMLAPVLEDVQSEMSDIKIVKINIDENQKAAETYGVTNIPTIKIFKEGKEVTTKVGFQHKDALIQMIKQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG4</accession>
    <name>A0A386PGG4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12450</name>
        <name evidence="2" type="ORF">EI377_07335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675328.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02023"/>
    <dbReference type="EnsemblBacteria" id="AYE35165">
        <property type="protein sequence ID" value="AYE35165"/>
        <property type="gene ID" value="CP523_12450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60568">
        <property type="protein sequence ID" value="QAS60568"/>
        <property type="gene ID" value="EI377_07335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="239" mass="27772" checksum="3F77FD0CB059C6AD" modified="2018-12-05" version="1">MMKFITEEYLRDLYRKEPFNTYKLQQGQRLTPGAAQYLSDKRIKISDNKPKNKNNASKNNMKFNEIEDKQIENNETEIVKKSEKSSLDLQKRFCYKLKAIESEILIISSEILKEDIFLAQNIINLGKKISNIRNFISGKGPLEVIICKECTGIKLSDFASELEDCFEITEFHIQLKNSNSILKMHTLRCKLQELKFELAEIYENDDTRNEIMRNLNSIINSLSQLICSAVGGKECQRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI5</accession>
    <name>A0A386PGI5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">CP523_10985</name>
        <name evidence="5" type="ORF">EI377_05780</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677667.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02531"/>
    <dbReference type="EnsemblBacteria" id="AYE34890">
        <property type="protein sequence ID" value="AYE34890"/>
        <property type="gene ID" value="CP523_10985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60285">
        <property type="protein sequence ID" value="QAS60285"/>
        <property type="gene ID" value="EI377_05780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10985"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="296" mass="33307" checksum="FDBF91362331D9A2" modified="2018-12-05" version="1">MKILLLGAKGQLGQQIIKIIKEKKSELGSLPKDIINAELVCMDIDDLDITNIDQVKSILNKEKPNIIINSAAFTNVDGCESNYDLAFKVNALGGRNLAIVSEEIGAKLVHISTDYVFDGKGSSPLKECDITVPISAYGKTKLLGENYVKDFCSRYFIVRTAWLYGYFGKNFVYTIMNAGRERGKLTVVNDQRGNPTNAEDLAYHVLKLAVTEEYGIYHCTGDGECTWYDFASKIIEYSGIDCEVLPVTSDEYKTPAKRPEYSSLDNMMLRNTIGDEMREWEEALKCFMNNKDKYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM7</accession>
    <name>A0A386PGM7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP pyrophosphokinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">GTP pyrophosphokinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11185</name>
        <name evidence="4" type="ORF">EI377_05975</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677054.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00903"/>
    <dbReference type="EnsemblBacteria" id="AYE34930">
        <property type="protein sequence ID" value="AYE34930"/>
        <property type="gene ID" value="CP523_11185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60324">
        <property type="protein sequence ID" value="QAS60324"/>
        <property type="gene ID" value="EI377_05975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11185"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="31030" checksum="CAB3ECC1F26117FE" modified="2018-12-05" version="1">MAIHDWKSFLMPYEQAVDELKVKLKSIRKEYRKKNEYSPIEFVTGRVKEVSSLLEKANKFQIPIDRLQYEIEDIAGLRIMCQFVDDIDTVVELLRARKDMQILYEKDYVRNVKTSGYRSYHMIIKYPINMAEGPTEILAEFQIRTLAMNFWATIEHSLNYKYKKQIPMEIQEKLKKAADAAFELDEQMLDIKDEIKDAQKLFEIKSDIVSNIMNSILTLISIGKVAEAGRYQVSLNKLIEEGEVWELNNLLASIKRDINKYRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT0</accession>
    <name>A0A386PGT0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04785</name>
        <name evidence="4" type="ORF">EI377_15295</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33836">
        <property type="protein sequence ID" value="AYE33836"/>
        <property type="gene ID" value="CP523_04785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61982">
        <property type="protein sequence ID" value="QAS61982"/>
        <property type="gene ID" value="EI377_15295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362716" evidence="2">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="168" mass="18796" checksum="44CAF24ACF7FF690" modified="2018-12-05" version="1">MNKKLFLKLGLLLLSLSLVSCGQKKNSSEEDNSSKSSTSQFVSSTQNSVKESVKTTNPSVENVVESKQEDVQKNTHPSVENAVESKQEDEDVQKDTHQEANEKDYYDLIKEAWQKQEDYIDSIDDSKVKQSVQTSHSAAIMKSTELLMNHPEDSEAIDESLKKVLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH00</accession>
    <name>A0A386PH00_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="1">2.6.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pabB</name>
        <name evidence="5" type="ORF">CP523_13525</name>
        <name evidence="6" type="ORF">EI377_08425</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677590.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00801"/>
    <dbReference type="EnsemblBacteria" id="AYE35365">
        <property type="protein sequence ID" value="AYE35365"/>
        <property type="gene ID" value="CP523_13525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60756">
        <property type="protein sequence ID" value="QAS60756"/>
        <property type="gene ID" value="EI377_08425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="3">
        <location>
            <begin position="190"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="451" mass="51994" checksum="93BAD0ABA996EFFB" modified="2018-12-05" version="1">MDLNIREIVTSLNPLEVYNIFKDKKNSILLDSSKDDRLLSKFSFIGINEFLKFESKGNKAFINDKEITGNPFNILESLISKYRIVEDKYDEIPFLSGCIGYISYDTCRILEDLPNTSKEDFIIPDMRFSFYDNLIIFDLINNKKYITSLGVVKNSEKSLDEIECKIKLGVRLNEEDIEGKNKNFNSNFTKKEYKNAISKLKDYIISGDVYIANMTQRFFCDCNDDAFKIYKRLRSINKAPFSAFMNYDDFQVISSSPERFIQVKDRKVHTRPIKGTRPRGNTKEEDYKNSQELLNSEKDKAELLMVVDLERNDLSKVCKNHSVKVTELFKLEEYATVFHLVSTVEGELKEEVSAVECIRECFPGGSITGTPKIRAMEIIEELEGVKRNLYTGSIGYFDLRGNSDFNIVIRTIVKKENKAYFGVGGGITYDSIEEDEYNETLDKAKALMRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH14</accession>
    <name>A0A386PH14_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpF</name>
        <name evidence="5" type="ORF">CP523_12005</name>
        <name evidence="6" type="ORF">EI377_06825</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673470.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02958"/>
    <dbReference type="EnsemblBacteria" id="AYE35080">
        <property type="protein sequence ID" value="AYE35080"/>
        <property type="gene ID" value="CP523_12005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60473">
        <property type="protein sequence ID" value="QAS60473"/>
        <property type="gene ID" value="EI377_06825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00312">
        <property type="entry name" value="ATP_synth_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022944">
        <property type="entry name" value="ATPase_V1-cplx_fsu_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="103" mass="11127" checksum="9F0FE9A2A5C62210" modified="2018-12-05" version="1">MYKKIGVVGDKDSVLAFKALGIDVFPVVGADEARIAVDKCARNDYAVIFVTEHVAQEIEDTIARYNEQVLPAVILIPSNQGSLNIGLKRISDSVEKAVGVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH22</accession>
    <name>A0A386PH22_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small, acid-soluble spore protein, alpha/beta type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13685</name>
        <name evidence="3" type="ORF">EI377_08575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677175.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35395">
        <property type="protein sequence ID" value="AYE35395"/>
        <property type="gene ID" value="CP523_13685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60784">
        <property type="protein sequence ID" value="QAS60784"/>
        <property type="gene ID" value="EI377_08575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="53" mass="6064" checksum="166D3457BF8C7927" modified="2018-12-05" version="1">MAHKNNKNSKANKKSNQKTKAELRKMQSETADEVGYSKESRKLGKNKPRSEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH69</accession>
    <name>A0A386PH69_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YafY family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12325</name>
        <name evidence="5" type="ORF">EI377_07215</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675375.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02047"/>
    <dbReference type="EnsemblBacteria" id="AYE35140">
        <property type="protein sequence ID" value="AYE35140"/>
        <property type="gene ID" value="CP523_12325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60545">
        <property type="protein sequence ID" value="QAS60545"/>
        <property type="gene ID" value="EI377_07215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="300" mass="35585" checksum="D0D5084497A56F25" modified="2018-12-05" version="1">MQANRLFEIIYILLEKNSVTAKELAERLEVSQRTIYRDIEALSTAGIPVYMSKGKGGGISILPEFILNKAILTEEEKTEILSSLRAVNAVNFNDVEMEKVLKKLNNILGENHTNWIEVDFSNWGNAEREKETFNNIKFAILNKRIVNFDYMSGKGESINRQVYPLKLYFKGQSWYMYGYCKIRNDYRFFKLRRIKDLYISKENFNIKMPINIMKEDNILKDEFITLKMKISSKMAYRVYDEFENFKQLDDGSFITIIEYPKGEWIFSYIFSFGEECEVLEPQEIREEIKNKIKKILFNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE4</accession>
    <name>A0A386PHE4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05615</name>
        <name evidence="2" type="ORF">EI377_00050</name>
        <name evidence="3" type="ORF">EI377_16130</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33982">
        <property type="protein sequence ID" value="AYE33982"/>
        <property type="gene ID" value="CP523_05615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59346">
        <property type="protein sequence ID" value="QAS59346"/>
        <property type="gene ID" value="EI377_00050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62124">
        <property type="protein sequence ID" value="QAS62124"/>
        <property type="gene ID" value="EI377_16130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="86" mass="10205" checksum="9AF4F96640601A7E" modified="2018-12-05" version="1">MEKYTCPVCGYPNLEEPPRDENGRPSFDICDCCGIEFGYEDCTEENIIRYRNKWIESDGEWFSKDSKPNNWSMEQQLKNIDIKLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG3</accession>
    <name>A0A386PHG3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09395</name>
        <name evidence="3" type="ORF">EI377_04140</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02738"/>
    <dbReference type="EnsemblBacteria" id="AYE34624">
        <property type="protein sequence ID" value="AYE34624"/>
        <property type="gene ID" value="CP523_09395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60024">
        <property type="protein sequence ID" value="QAS60024"/>
        <property type="gene ID" value="EI377_04140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="475"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="507" mass="57151" checksum="9048C6131FB4E257" modified="2018-12-05" version="1">MGDYKKLTPTNGFDFKDLLNARQNNYAWSMGELGEYIYVGTGRNIVVSIIKAMATNFGVDPNDINFPISIKPNSEDNLGEIWRYKKDGSLPWKRVFKAETGSGIQGFRFMISNRPFGGNPCLYAAAFGDEIKILKTTNGVDWEYVNNEGLEGTSSRAMVIHRRKVYVATINEFNLDETPLLYASREPEFYSWESVIGSGANNPKGAITNMEVFNNRVYVATSSEDGVQVWRSRNRDPKPNEWVCIVDKGFGDAANTFTLSIGVFGQHLYVSASKLLPLSWIIPFGCDIIRIDKRDNWRLVVGGPALIKTNPIGHRGKSLSGLGSGFDNPFNVYAWQIQEYKGKLLVSTFDSATNVELILDLILANRDLLEAELGIVIVEALIRIFELAVRILNEKNYPFGFNLYVSDDGIHFDLAIRKGLCNRYNYGGRILYVDKCNDLYIGTANPYQGCEVWRTDNVLPCYPCYSNQLYSSDPGEIYNEIYAEAEEDLAKVQEKMPEVIEILKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG4</accession>
    <name>A0A386PHG4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03620</name>
        <name evidence="4" type="ORF">EI377_14150</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02221"/>
    <dbReference type="EnsemblBacteria" id="AYE33619">
        <property type="protein sequence ID" value="AYE33619"/>
        <property type="gene ID" value="CP523_03620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61783">
        <property type="protein sequence ID" value="QAS61783"/>
        <property type="gene ID" value="EI377_14150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="230" mass="26490" checksum="BEB9B85E400C856A" modified="2018-12-05" version="1">MNLITLRETLIKDLKPFIENIITVKNKVSLLEQETERDKIIIKLNGTIKASHMLPNSKELLLGIYKSETIIFPAIFNMENNFSSLFKISTLTDCTFGLISINTLRTIINKDITILRNLCLYHDFLCQKIFLQMRDLSFYDKKLALFSILIRLCNTYGVKTNNGWKINTKLSNILLSEYIGTTPETISRLISKLKSKDLIEFKHGFLTIKDLCYLKKSLGCSKCNESLCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG9</accession>
    <name>A0A386PHG9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="6" type="ORF">CP523_14575</name>
        <name evidence="7" type="ORF">EI377_09545</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678671.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00197"/>
    <dbReference type="EnsemblBacteria" id="AYE35555">
        <property type="protein sequence ID" value="AYE35555"/>
        <property type="gene ID" value="CP523_14575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60942">
        <property type="protein sequence ID" value="QAS60942"/>
        <property type="gene ID" value="EI377_09545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="65" mass="7515" checksum="6F667979AE5D5056" modified="2018-12-05" version="1">MPKMKTHRGAAKRFKKTGTGRLKRAKAFKSHILTKKSAKRKRNLRKAAYVSTTQEKAMKKLLPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN3</accession>
    <name>A0A386PHN3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10970</name>
        <name evidence="4" type="ORF">EI377_05765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677662.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02528"/>
    <dbReference type="EnsemblBacteria" id="AYE34887">
        <property type="protein sequence ID" value="AYE34887"/>
        <property type="gene ID" value="CP523_10970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60282">
        <property type="protein sequence ID" value="QAS60282"/>
        <property type="gene ID" value="EI377_05765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="369" mass="42014" checksum="9322C8C749A2BA13" modified="2018-12-05" version="1">MNRVCILNALQTSLSGGIGRYSYELSKSLYEKEKSNIKIVIREEDRKDFLFAKDEDLIIVKNIKSGIHRNIYEQIILPFKARKINKNAILHYPDSMAPLLALNDVVITVHDLAFKTLKGAFTWKTALWKKIITPLSIIKAKKVVAITEFAKSEIYTHYRNIAKDKVVVVYNGFNNLNVEKNDRTEVIRNEKLKLNIDKPYILTVSTISPRKNIDGLIKAFNIIKDKTECNLIVGGKNGWLYESVYETVENLNLKERVIFTGSVTDYELSQMYKNCALFVYPSFYEGFGLPPLEAMSYNKKCAVSNSTSIPEVVGSAGIYFDPSKVEDIAEKLLLALNRDIDVNLIQSVLNKFSWKKCADGVIKKVYDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP3</accession>
    <name>A0A386PHP3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ychF</name>
        <name evidence="8" type="ORF">CP523_14835</name>
        <name evidence="9" type="ORF">EI377_09795</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676100.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01315"/>
    <dbReference type="EnsemblBacteria" id="AYE35603">
        <property type="protein sequence ID" value="AYE35603"/>
        <property type="gene ID" value="CP523_14835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60990">
        <property type="protein sequence ID" value="QAS60990"/>
        <property type="gene ID" value="EI377_09795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="365" mass="40902" checksum="5C4167C1950F228C" modified="2018-12-05" version="1">MNLGIVGLPNVGKSTLFNAITKAGAESANYPFCTIEPNVGVVSVPDKRLDVLEKIYNTKRKIYTSVEFYDIAGLVKGASKGEGLGNKFLSHIREVSAIVHAVRCFEDENVVHVEGSVDPIRDIETINLELIFADLEVLERRMERSMKQVRSGDKKAKQEYELMERVKAHLEKNLPIRTMEFNEDEEELVKGLFMITSKPVLYSCNISEDDMMSGNVNNEYVQKVREYAEAENSEVVVVCAKLEEELSGLEDEEKAEMLAEYGLTESGLDKLIRASYKLLGLMSYLTAGVQEVRAWTIKQGTKAPQAAGKIHSDIERGFIRAEVVAYDDLIECGSEAAAKEKGLYRLEGKDYIMKDGDVVNFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS4</accession>
    <name>A0A386PHS4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="5" type="ORF">CP523_06545</name>
        <name evidence="6" type="ORF">EI377_01030</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE34156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AYE34156">
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        <property type="gene ID" value="CP523_06545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59524">
        <property type="protein sequence ID" value="QAS59524"/>
        <property type="gene ID" value="EI377_01030"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Primosome_PriB/ssb"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="13735" checksum="000204009681BDB8" modified="2018-12-05" version="1">MNKIVLLGKLIRDPELKTLENNEKLFTRFIIAVDRNFKSQDGTRKADLIPVTLWGRKAEVVCKYMKKGSYISLSGRLRTGSYEDKDGNKKYIAEVVGEDFKFVGGRKWEKEEDSTEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW7</accession>
    <name>A0A386PHW7_CLOSE</name>
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        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_13660</name>
        <name evidence="7" type="ORF">EI377_08550</name>
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    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
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    <reference evidence="8" key="1">
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            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677185.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35390">
        <property type="protein sequence ID" value="AYE35390"/>
        <property type="gene ID" value="CP523_13660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60779">
        <property type="protein sequence ID" value="QAS60779"/>
        <property type="gene ID" value="EI377_08550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="38"/>
            <end position="61"/>
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            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="476" mass="52940" checksum="70DF224CD87E75A5" modified="2018-12-05" version="1">MTDNSKNIRWYNLALMAFVSVWGFGNVVNNYANQGLTVVVSWVLIIALYFVPYALMVGELGSTFKDAKGGVSTWIRETMGPTVAYFAGWTYWVVHIPYLAQKPQSVLIALGWTVKQDGSLIKNMPTLQAQAITLVVFLIFLWIASRGVTSLKRIGTIAGTSIFIMSLLYILLMVAAPAIRGVEPATTNITFKTIMPEFNFAYFTTLSMLVFAVGGCEKISPYVNNMKNSSKEFPRGMIILAVMVAVSAILGSVAMGMMFDSHNIPRDLMMNGQYYAFQKLGEYYGVGKLLLVIYALANMLAQISALVFSIDAPLKVLLSDSDSKYIPKALTKTNKHGAPINGYYMTAILVGVLIIIPALGIGDMNTLFDWLLKLNSVVMPLRYLWVFLAFIMLKKAKDKFQSDYKFVKNDKFALITGIWCFIFTAFACIMGMFPNGVETYSKQWWFQIVLNVLTPFVLLGLGLILPKIASKTNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW8</accession>
    <name>A0A386PHW8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triple tyrosine motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09670</name>
        <name evidence="3" type="ORF">EI377_04450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676716.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02640"/>
    <dbReference type="EnsemblBacteria" id="AYE34671">
        <property type="protein sequence ID" value="AYE34671"/>
        <property type="gene ID" value="CP523_09670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60071">
        <property type="protein sequence ID" value="QAS60071"/>
        <property type="gene ID" value="EI377_04450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="221"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="413"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Y_Y_Y" evidence="1">
        <location>
            <begin position="510"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="670" mass="78272" checksum="3FDF9CE8773BFD9C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY5</accession>
    <name>A0A386PHY5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitronate monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10425</name>
        <name evidence="3" type="ORF">EI377_05195</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01415"/>
    <dbReference type="EnsemblBacteria" id="AYE34784">
        <property type="protein sequence ID" value="AYE34784"/>
        <property type="gene ID" value="CP523_10425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60179">
        <property type="protein sequence ID" value="QAS60179"/>
        <property type="gene ID" value="EI377_05195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="12"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="355" mass="38162" checksum="10526E9CCE99046C" modified="2018-12-05" version="1">MNIKPLIIGDLIAKIPIVQGGMGIGVSLSNLASAVAKAGGIGIISGAQTGYKEDDFETNTLEANLRALKKHIKLAKEKSNNGIIGVNLMVAMNKYKEHVEAAIEAGVDLIISGAGLPTKLPKYTKGFKVKLAPIVSSCKAAKVILNIWDKHYGITADMVVIEGPKAGGHLGFNKEKLQEETEAFDETITNIIKVIKDFEIKYKKSIPVIVAGGVFNGYDIAKYLKLGASGVQMATRFVATNECDADIKFKEAYINCSEANIDIVKSPVGMPGRAIVNNFVKRTLNSNINVSKCYNCLIPCNPATTPYCITEALINAVKGNVENGLIFCGENASKIKKIVSVQDLMNELTEEIKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ7</accession>
    <name>A0A386PHZ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1,3-beta-galactosyl-N-acetylhexosamine phosphorylase</fullName>
            <ecNumber evidence="5">2.4.1.211</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gnpA</name>
        <name evidence="4" type="ORF">CP523_06955</name>
        <name evidence="5" type="ORF">EI377_01440</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.211" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01006"/>
    <dbReference type="EnsemblBacteria" id="AYE34212">
        <property type="protein sequence ID" value="AYE34212"/>
        <property type="gene ID" value="CP523_06955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59577">
        <property type="protein sequence ID" value="QAS59577"/>
        <property type="gene ID" value="EI377_01440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050500">
        <property type="term" value="F:1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035080">
        <property type="entry name" value="Lact_bio_phlase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012711">
        <property type="entry name" value="Lacto-N-biose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035356">
        <property type="entry name" value="LBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09508">
        <property type="entry name" value="Lact_bio_phlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17386">
        <property type="entry name" value="LBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02336">
        <property type="entry name" value="TIGR02336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lact_bio_phlase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_M" evidence="2">
        <location>
            <begin position="439"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_C" evidence="3">
        <location>
            <begin position="664"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="718" mass="82793" checksum="1130B3F42289C6CC" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI32</accession>
    <name>A0A386PI32_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF503 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11595</name>
        <name evidence="2" type="ORF">EI377_06410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673350.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02877"/>
    <dbReference type="EnsemblBacteria" id="AYE35007">
        <property type="protein sequence ID" value="AYE35007"/>
        <property type="gene ID" value="CP523_11595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60400">
        <property type="protein sequence ID" value="QAS60400"/>
        <property type="gene ID" value="EI377_06410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="95" mass="10928" checksum="02A19E27A29EA5F5" modified="2018-12-05" version="1">MKVLLMKVKLRASWVHSLKEKRMVVRRITERLKNKFNISVAEVEDQDIHQIIVIGISAICGSSAKVHSTLENIINFIECNTDAEIINIDTFEDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI37</accession>
    <name>A0A386PI37_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_00280</name>
        <name evidence="7" type="ORF">EI377_10605</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01177"/>
    <dbReference type="EnsemblBacteria" id="AYE35785">
        <property type="protein sequence ID" value="AYE35785"/>
        <property type="gene ID" value="CP523_00280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62203">
        <property type="protein sequence ID" value="QAS62203"/>
        <property type="gene ID" value="EI377_10605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="174" mass="20288" checksum="3592FC28024503A8" modified="2018-12-05" version="1">MKLYEFILWFYVYSFLGWICETIYCSIPAKNFIKRGMLKGPVCPIYGFGSLFAITLLNKCDYKIYTIFILGLLLASILEFITSFLLEKIFNRKWWDYSKNKFNINGRVCLLNSTLFGILSVCLIKFIHPIVIFILIKIPLCIIEKITRSIVIIFVLDAGTTFFNLYQSRKGLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI71</accession>
    <name>A0A386PI71_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="11" type="ORF">CP523_07545</name>
        <name evidence="12" type="ORF">EI377_02235</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673815.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01118"/>
    <dbReference type="EnsemblBacteria" id="AYE34306">
        <property type="protein sequence ID" value="AYE34306"/>
        <property type="gene ID" value="CP523_07545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59700">
        <property type="protein sequence ID" value="QAS59700"/>
        <property type="gene ID" value="EI377_02235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L9_C" evidence="10">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="148" mass="16437" checksum="A5C6BC7F69C25E6D" modified="2018-12-05" version="1">MKVILLQDVKKLGKKGDVIEVSDGYARNFLFPRNLVQEATGNNLHVLNTKKENERKKKLAELEAAQKLAAELKGKEVTLKAKGGDNGRLFGAITSKDVATLINKEFNLSIDKKKIVMDTIKVAGGYEIEIKLYPEVTTKMRVIIVPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA9</accession>
    <name>A0A386PIA9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="9" type="ORF">CP523_07815</name>
        <name evidence="10" type="ORF">EI377_02505</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679159.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02104"/>
    <dbReference type="EnsemblBacteria" id="AYE34342">
        <property type="protein sequence ID" value="AYE34342"/>
        <property type="gene ID" value="CP523_07815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59738">
        <property type="protein sequence ID" value="QAS59738"/>
        <property type="gene ID" value="EI377_02505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07815"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="174"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Serine binding" evidence="7">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="264"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="351"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="425" mass="48689" checksum="69CA7B7BA37CE838" modified="2018-12-05" version="1">MLDLKRIRNNPEEIKKALANRGEDFQESTIDEIIALDEQRRNILVDVEALKSKRNQVSAEIPKLKKAGEDVTAIMTEMRELGDKIKEDDAKISEIDEKLEYIMLRMPNIPNPQVPEGDTDEDNVEIKKWGEPTKFNYEPKAHWDLGTDLNIFDFERAGKVTGSRFTIYKGLGARLERAIINYFLDKHTFENGYEEVLPPYMVNRDSMTGTGQLPKFEEDAFKVENNGYFLIPTAEVPVTNMYRNETLKGTDLPVKHVAYSACFRAEAGSAGRDTRGLIRQHQFNKVELVKFCKPEQSYDELDKLVKDAESVLQGLGLPYRIVRICKGDLGFTAALKYDIEVWMPSYNRYVEISSCSNFEDFQARRANIKYKETPKDKPQFVHTLNGSGVAIGRTVAAILENYQREDGTVEIPEALRRFMNCDEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID9</accession>
    <name>A0A386PID9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14650</name>
        <name evidence="3" type="ORF">EI377_09615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678862.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35570">
        <property type="protein sequence ID" value="AYE35570"/>
        <property type="gene ID" value="CP523_14650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60956">
        <property type="protein sequence ID" value="QAS60956"/>
        <property type="gene ID" value="EI377_09615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="347" mass="40504" checksum="5132EA0AA5230810" modified="2018-12-05" version="1">MGFWNLFKKKINEEYEDSAENYEEEIDTGEHKVSSVDIEYEFSEGIKNEVLQEKSIQEKEERVRKLSPEEINELITNEILNVIENHDDFEKLKESASEAVKNIGDEYMYLMPQYLIDKLPRPKNLREQYDMLDEWPMVVENAVLMILFSYQEKGVEYLSKIAYRNSSVNISLRLKAINLLCKLAADGVDCEGIVNKTMNNLMAFDDENKIKIFGFMSQIKSNNQVIGLIQHFYKSFVKHGDIEYGYNTLLHLINAAEKYTPGHLNFLKMVALGKGTINLEEIMGLEENEEKVIYIKDINEKCKVRAAITYYSLEKTDSDINSKLYYWSEYSLDKYIREEIKQVISEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE5</accession>
    <name>A0A386PIE5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS lactose/cellobiose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_12255</name>
        <name evidence="9" type="ORF">EI377_07080</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per trimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673594.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03006"/>
    <dbReference type="EnsemblBacteria" id="AYE35127">
        <property type="protein sequence ID" value="AYE35127"/>
        <property type="gene ID" value="CP523_12255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60519">
        <property type="protein sequence ID" value="QAS60519"/>
        <property type="gene ID" value="EI377_07080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00215">
        <property type="entry name" value="PTS_IIA_lac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34382">
        <property type="entry name" value="PTHR34382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000699">
        <property type="entry name" value="PTS_IILac_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared between all trimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="6">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="12001" checksum="07D5FCEE4007CCE8" modified="2018-12-05" version="1">MNLEEIIMQIIISGGDSKSYVMEAIEEARNRNIEKARELIKKADTQLRNAHSIQTELIQNEARGEKITVELLMVHAQDHLMNAITVRDLGEQLVNMYEMFLKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF2</accession>
    <name>A0A386PIF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08080</name>
        <name evidence="3" type="ORF">EI377_02835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675949.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34386">
        <property type="protein sequence ID" value="AYE34386"/>
        <property type="gene ID" value="CP523_08080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59791">
        <property type="protein sequence ID" value="QAS59791"/>
        <property type="gene ID" value="EI377_02835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="217" mass="24291" checksum="C808D7A69C443416" modified="2018-12-05" version="1">MKEKALKLQNLLIAILIFALVSIFVIEGIKTNAEYKKVSDSTIQENSDKNKVDKEKEETKKETEKKKDAEKKKETEKKKDDSNKTPVAPTEETNKTNQQESIDTNTNTNEAESSSTESNDTTIWYPESSNDNSDYIPINDYVPNLDSDSSNQDNGQSNQGNDQTNQDNVQSNQGNEQPSEDHEQFNPDEHHPVSDADHNNATGDIYPAPPTVDGEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG1</accession>
    <name>A0A386PIG1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class I SAM-dependent rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08170</name>
        <name evidence="6" type="ORF">EI377_02925</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674686.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01577"/>
    <dbReference type="EnsemblBacteria" id="AYE34402">
        <property type="protein sequence ID" value="AYE34402"/>
        <property type="gene ID" value="CP523_08170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59808">
        <property type="protein sequence ID" value="QAS59808"/>
        <property type="gene ID" value="EI377_02925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="391" mass="44990" checksum="D257EEFF48CBF6C3" modified="2018-12-05" version="1">MACKFYLHKGKNKRAEQGRPWIYIDEINEYDGDYENGDIVEVYNHKNYFIGKGYINDRSKITIRIMTRDINEEIDETFFIKRFAMAWDYRKTVIDTSSCRFIFGEADFLPGLTVDKFEDYYVIQISTLGMDKYRDLIVKILVEQYGAKGVYERSDIKTREIEGLEQTKGFLTESFDTNIQIVENGVKYIVDLENGQKTGFFLDQKENREAIHKICKGKDVLDCFTHTGSFALNAAIAGANSVLGIDVSQHAVDCATRNAQLNGLQDIAKFECHNAFDILGDWSRDGKQFDVVILDPPAFTKSRNTIKAAIRGYKEINLRGLRMVKSGGYFATCSCSHYMSEEQLKKTVLEAAHDARKTLRQIECRTQSSDHPILWNSDESYYLKFFIFQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ1</accession>
    <name>A0A386PIJ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">trpS</name>
        <name evidence="10" type="ORF">CP523_11040</name>
        <name evidence="11" type="ORF">EI377_05830</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677106.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00932"/>
    <dbReference type="EnsemblBacteria" id="AYE34901">
        <property type="protein sequence ID" value="AYE34901"/>
        <property type="gene ID" value="CP523_11040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60295">
        <property type="protein sequence ID" value="QAS60295"/>
        <property type="gene ID" value="EI377_05830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="18"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="25"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="336" mass="37862" checksum="4F48F499B79B45C3" modified="2018-12-05" version="1">MENNTIEKKKVIFSGIQPSGDLTLGNYLGAIKNWVALQDEFDCYFCVVDLHAITVKQEPKDLRRRTLELLAIYISSGIIPEKNTLFIQSHVPAHSECAWLLTCNTYMGELSRMTQYKDKSKKYGDSIGAGLFNYPTLMAADILLYNTDLVPVGQDQKQHLELARDIANRFNNVYSPTFKVPDPYIPKVGAKVMSLQDPTKKMSKSDDNPNSYILIMDSPDVIRKKVSRAVTDSIGIINYCDEQPGVKNLINILCATKGSTPEELVKYYKGKGYADLKKDVAEAIIAELEPVQNKVKDILADKKYLEEIYKSGAEKASYNANKILRKMQKKIGFIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ3</accession>
    <name>A0A386PIJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12565</name>
        <name evidence="2" type="ORF">EI377_07455</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675260.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02000"/>
    <dbReference type="EnsemblBacteria" id="AYE35187">
        <property type="protein sequence ID" value="AYE35187"/>
        <property type="gene ID" value="CP523_12565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60590">
        <property type="protein sequence ID" value="QAS60590"/>
        <property type="gene ID" value="EI377_07455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="15001" checksum="4657C57E43CF9890" modified="2018-12-05" version="1">MEETLIYDINSIHTDKDLNIKIRYSNVSLENNEVKGPWEFEFKSSGEEFALATKELDLGYSFTLESGEKIILNKYKTNDIGQKIYYTAENKAESYDMVLRGNDDLGNPVEFYLSSGSKTEGVFKNSSIEGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN1</accession>
    <name>A0A386PIN1_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12895</name>
        <name evidence="3" type="ORF">EI377_07775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
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    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE35247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678234.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35247">
        <property type="protein sequence ID" value="AYE35247"/>
        <property type="gene ID" value="CP523_12895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60642">
        <property type="protein sequence ID" value="QAS60642"/>
        <property type="gene ID" value="EI377_07775"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="153" mass="17691" checksum="D8DA4CA8B116930A" modified="2018-12-05" version="1">MKETKILNDIGMVYHWMRKILKDCDTSGLNLPLNKTQERVIVMIYKHPRNTMSMICNCVGLEKGSFTGVVDTLMSLGYITRERSDNDRRKISLSLTKKGEDIAIAVEEEMYKELKKVIYQYGEDEGQILIDSISKIAEFARRKAGYDKEKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ2</accession>
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        <submittedName>
            <fullName evidence="2">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13060</name>
        <name evidence="3" type="ORF">EI377_07930</name>
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    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
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    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677835.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35277">
        <property type="protein sequence ID" value="AYE35277"/>
        <property type="gene ID" value="CP523_13060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60671">
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        <property type="gene ID" value="EI377_07930"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="95" mass="11177" checksum="4135B94B193CA618" modified="2018-12-05" version="1">MEQTLISRQKLAERWDFANPNSLIKYESEGIITRNPNFKAPKYYMEEILKIESLGKVNPLSPLERKRLEKRISELEIENKSIKERLNNGRIALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ41</accession>
    <name>A0A386PJ41_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkaline phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12585</name>
        <name evidence="2" type="ORF">EI377_07490</name>
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    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 7534</strain>
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="protein sequence ID" value="QAS60595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01996"/>
    <dbReference type="EnsemblBacteria" id="AYE35191">
        <property type="protein sequence ID" value="AYE35191"/>
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    </dbReference>
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        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
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        <property type="entry name" value="Phosphodiest"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AYE35191.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS60595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="434" mass="49330" checksum="1CBFB92FEBCACA78" modified="2018-12-05" version="1">MQTKHLIVISFDGVSSEDIEILGELPNFSKLIKGGALIKNVETIYPSLTYPAHATIVTGCYPNKHGIINNTLLEFGDENPNWYWYRKYIKKETIFDLAEKKGLKTCSILWPVTGRSKITYNMPEICCTKSWHNQIIMSALAGTISYQLPLNKKYGSLRKGISQPYLDNFSMEVAKDTIINRKPNLMLLHLVDVDSQRHYTGYKSKEVKEALIRHDKRLGEIIDTLKEANILEESTIVALGDHSQIDVDKIIRINSLFTEKNLITLDGRGKLKDYKAIAKNCDGSSYIYLKDKNDNKVKEEVKKILEEANSTYNNPFEFILDSNEAENLGADPNCDFMVEGNFGYSFIDEVTGDFIEKIKEEDIGEKPHRVKATHGYFPKKENYTTFFIAYGNSIKKGFTLENGSLINHGPTLARILGLELKDIDGNIEEKIFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ95</accession>
    <name>A0A386PJ95_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIGR03905 family TSCPD domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">TIGR03905 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14455</name>
        <name evidence="3" type="ORF">EI377_09430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF12637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="81" mass="8821" checksum="CF9EDD415BA61C25" modified="2018-12-05" version="1">MFVYKTKGVCSTEIHVDVEDNKIKNVEFVKGCPGNLFGISSLVKGMDIDSAIEKLKGIKCGNKDTSCPDQLAKALEEIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="QAS59693.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="64" mass="7204" checksum="696C5AF9998E2C88" modified="2018-12-05" version="1">MITEDMTLNDAILKNPGAQSILMSFGIGCGILNKNEEETLKEACIEHGVNLEVLLRELNFSRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">VAT12</strain>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35374">
        <property type="protein sequence ID" value="AYE35374"/>
        <property type="gene ID" value="CP523_13570"/>
    </dbReference>
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        <property type="gene ID" value="EI377_08465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13570"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="QAS60764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="144" mass="16818" checksum="A6F901341FE7C853" modified="2018-12-05" version="1">MKVGIDINNRKILLTVVEKMKERGHWVVDLSNEERGNKGQIVFRKTLLANVTKVDFYMGIEFVDNISKYELFYDENFLSEVCCNELKKVITRLNKELNCIGGSNLYLVKNTNSPAVYMKIPMEDRDIIEDYCLDEIIEILLKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI2</accession>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 6">VAT12</strain>
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        <location>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="AYE34349.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS59746.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00724"/>
    <dbReference type="EnsemblBacteria" id="AYE34379">
        <property type="protein sequence ID" value="AYE34379"/>
        <property type="gene ID" value="CP523_08045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59785">
        <property type="protein sequence ID" value="QAS59785"/>
        <property type="gene ID" value="EI377_02805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="273" mass="31329" checksum="2416F148EC03210D" modified="2018-12-05" version="1">MSKIFNGYLLVSDMDGTLLNSKGELSQENIRAIDYFVDNGGVFTLATGRMLASAGRFVPNLKIGLPVILYNGSKVYDYSNKKLLHENYLEEKRKEIVKKLQQEKPNLGIEVFSEEKNYIIQKCKYTDRLANSVCETIYDIPDELWKQKWTKILMIGEEEVVDELEENFHLICDNVEVLRSGDKFLEIVPEYTSKGSALKKLIEDFDIDPSKVIAVGDSMNDREMLKTAKFGFCTENGIKRLVEEAKFKAPKNDDNAVEYVVRWLEEKILKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK00</accession>
    <name>A0A386PK00_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">mraZ</name>
        <name evidence="10" type="ORF">CP523_14845</name>
        <name evidence="11" type="ORF">EI377_09800</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676098.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01314"/>
    <dbReference type="EnsemblBacteria" id="AYE35604">
        <property type="protein sequence ID" value="AYE35604"/>
        <property type="gene ID" value="CP523_14845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60991">
        <property type="protein sequence ID" value="QAS60991"/>
        <property type="gene ID" value="EI377_09800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14845"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="142" mass="16202" checksum="FD28E4EE2E14C8D5" modified="2018-12-05" version="1">MFIGEYQHALDTKNRMIVPAKLREGLGSKFVITKGLDGCLYAYPESEWKILEAKLKTLPLTNKDARSFVRFFFSGACEIETDKQGRGLIPQNLKEYAGIEKEIVSIGVLSRVEIWSKEKWQEYNESDVDFDSIAEKMSDLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK26</accession>
    <name>A0A386PK26_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 3">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpt</name>
        <name evidence="5" type="ORF">CP523_13995</name>
        <name evidence="6" type="ORF">EI377_08900</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678655.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00216"/>
    <dbReference type="EnsemblBacteria" id="AYE35877">
        <property type="protein sequence ID" value="AYE35877"/>
        <property type="gene ID" value="CP523_13995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62188">
        <property type="protein sequence ID" value="QAS62188"/>
        <property type="gene ID" value="EI377_08900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13995"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="174" mass="20044" checksum="A84E108E2877481C" modified="2018-12-05" version="1">MENKKRNILFTEEQIKTRISELGKIITEEYKNKKLYVLPLLRGSFVFGADLFRALDCKAKVGFMTTSSYGHGEHSTGEVKVVNDIPDNIEGWDVLIVDDIMDTGYTMDFVINYVKSRGANSVKTCVLLDKPSRRKVNLTPDYCCFEIEDLFVVGYGLDYESFYRNVPYVFNWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK78</accession>
    <name>A0A386PK78_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Recombinase XerD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_15145</name>
        <name evidence="9" type="ORF">EI377_10100</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679003.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00099"/>
    <dbReference type="EnsemblBacteria" id="AYE35661">
        <property type="protein sequence ID" value="AYE35661"/>
        <property type="gene ID" value="CP523_15145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61047">
        <property type="protein sequence ID" value="QAS61047"/>
        <property type="gene ID" value="EI377_10100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="292" mass="33779" checksum="4524DB5E25CB7970" modified="2018-12-05" version="1">MKEIVNEYRESLLKSHKSENTVYAYVTDVNLYVKYLNNKNIDINETDNVSVLGYIQYLLSQGKSERSINRIVISLRSFYNYLKDQKVVKEIPKIYYKSTATAKKLPEILTVEEIDRIIKIVDKDCNKGTRDNALLELMYATGMKVSEIIGLKVWDVNLDLSFVKCHDNKNYERLIPIGRSALEALKDYFKIRDQIASAGVDNLFVNLNGNQLTRQGVWRIVKEYSHKAGIKKEVNLNTFRHSFAVHLLQNGANVRAVQKLLGNQVLTYMDTYYEIINNDKINLVYKNSHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKC7</accession>
    <name>A0A386PKC7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta fold hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13750</name>
        <name evidence="3" type="ORF">EI377_08640</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677155.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02072"/>
    <dbReference type="EnsemblBacteria" id="AYE35408">
        <property type="protein sequence ID" value="AYE35408"/>
        <property type="gene ID" value="CP523_13750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60796">
        <property type="protein sequence ID" value="QAS60796"/>
        <property type="gene ID" value="EI377_08640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="25"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="35651" checksum="5E6ACCEE7231CB14" modified="2018-12-05" version="1">MENFIFRDKEGLDINYYKWSPDVDEVKGIIQIAHGMTETALRYDYFAKKLTKEGYIVYAHDHRGHGDTAKSKENLGYVADDEGFYWMVNDIKELNDIIKKENPNKKVVLFGHSMGSFLSQRYFQLYGDKIDGLILSGSNGRPKNITKLGILVAKLEMTIKGRKAKSRLMDKLSFGDFNNNFKPNRSNYDWLCSVEEEVDKYIQDEKCGFICSTSFYYDLIRGLWDIHKEENLNGVPKNKPVYIFSGDKDPVGYFGVGVKNLYETLKRNGVSDIEYKLYENGRHEMLNEKNKDEVILDIIDWIKCKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKG5</accession>
    <name>A0A386PKG5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">pyrB</name>
        <name evidence="9" type="ORF">CP523_13935</name>
        <name evidence="10" type="ORF">EI377_08825</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678807.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00154"/>
    <dbReference type="EnsemblBacteria" id="AYE35438">
        <property type="protein sequence ID" value="AYE35438"/>
        <property type="gene ID" value="CP523_13935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60825">
        <property type="protein sequence ID" value="QAS60825"/>
        <property type="gene ID" value="EI377_08825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13935"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
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        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="151"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="306" mass="34854" checksum="88605CC28EE74D9C" modified="2018-12-05" version="1">MKNKHLIDPSDFNLEELDEIFKLAHQIISNPKKFSNICDGKILATLFYEPSTRTRFSFEAAMMRLGGKILGFSEPNSSSASKGETLADTIKVVSIYSDIIAMRHPKEGSAKVASMYSSVPVINAGDGGHQHPTQTLTDLLTIESLKNGLENHTIGICGDLKNGRTVHSLIKAMSRYNGNRFILISPKELVIPEYIREEILKNNNIEFREVERLEDVISELDILYMTRIQKERFFNEDEYIRLKDSYILDNCKMNLAKKDMIVLHPLPRVNEVSMKVDKDERAAYFKQAEYGMYVRMALIAKLLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI9</accession>
    <name>A0A386PKI9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2',3'-cyclic-nucleotide 2'-phosphodiesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Multifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase/5'-nucleotidase</fullName>
            <ecNumber evidence="10">3.1.3.5</ecNumber>
            <ecNumber evidence="10">3.1.3.6</ecNumber>
            <ecNumber evidence="10">3.1.4.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12975</name>
        <name evidence="10" type="ORF">EI377_07850</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="10"/>
    <dbReference type="EC" id="3.1.3.6" evidence="10"/>
    <dbReference type="EC" id="3.1.4.16" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02535"/>
    <dbReference type="EnsemblBacteria" id="AYE35262">
        <property type="protein sequence ID" value="AYE35262"/>
        <property type="gene ID" value="CP523_12975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60657">
        <property type="protein sequence ID" value="QAS60657"/>
        <property type="gene ID" value="EI377_07850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788421" evidence="7">
        <location>
            <begin position="33"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1099"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128096" checksum="7FB7176ECF89EDED" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKQ7</accession>
    <name>A0A386PKQ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14590</name>
        <name evidence="4" type="ORF">EI377_09560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678669.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00194"/>
    <dbReference type="EnsemblBacteria" id="AYE35558">
        <property type="protein sequence ID" value="AYE35558"/>
        <property type="gene ID" value="CP523_14590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60945">
        <property type="protein sequence ID" value="QAS60945"/>
        <property type="gene ID" value="EI377_09560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="139"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="24014" checksum="BB5DCEFDF4FDBB52" modified="2018-12-05" version="1">MANKQFVVLGLGRFGHSVAKTLYALGNDVLAIDMDGDLVQEISDSVTHAVQLDATDENALRSLGLRNFDVAVVTIGSNIQASVMATLLVKELGVKYIIAKGHSDLHAKVLYKIGADRVVLPEKDMGVRVAHNLVSASIVDYIELSPDYSIMEIQALDEWDGKTLDELRLRSKYGINVMAIKNGDEINLTPSAQDKVNAKDVIVAIGSAEDLSKLEGVIVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKY6</accession>
    <name>A0A386PKY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678556.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03115"/>
    <dbReference type="EnsemblBacteria" id="AYE35678">
        <property type="protein sequence ID" value="AYE35678"/>
        <property type="gene ID" value="CP523_15255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="197" mass="22564" checksum="902B8448017A3CCF" modified="2018-12-05" version="1">MEVSKSKIHRWSEEEKKYLAEITPGKHYSEILELMNKKFKNTFTISQIKGAIGRYKLNTGFTGKFEKGNIPKNKGTKGLTGANKTSFKKGNRPVNYRAIGSERINVDGYLEVKVADPNKWRLKHRVIWEQYNGKIPKGYNVLFGDSNKLNLDINNLILVSKKQLLVMNKNKLIQDNFYLTKTGSIIAKLIIMVGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKY7</accession>
    <name>A0A386PKY7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="7" type="ORF">CP523_14570</name>
        <name evidence="8" type="ORF">EI377_09540</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678684.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00198"/>
    <dbReference type="EnsemblBacteria" id="AYE35884">
        <property type="protein sequence ID" value="AYE35884"/>
        <property type="gene ID" value="CP523_14570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60941">
        <property type="protein sequence ID" value="QAS60941"/>
        <property type="gene ID" value="EI377_09540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="6">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="5">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="19499" checksum="D5C45200047FF48B" modified="2018-12-05" version="1">MNNINKNYSVNENIREKEVRVIDSDGSQLGVIATTEALKIAEERELDLVMISPSAKPPVCKVMDLGKFIYEQSKKEKEAKKKQKITSVKEVRCSLNIEEHDIAIKAKNARKFLLDGDKVKVTVRFRGREAELGHLGKKILDNFASKLEDVCIVEKSAKQEGRNMTMILGPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL04</accession>
    <name>A0A386PL04_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13640</name>
        <name evidence="2" type="ORF">EI377_08530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677190.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02094"/>
    <dbReference type="EnsemblBacteria" id="AYE35386">
        <property type="protein sequence ID" value="AYE35386"/>
        <property type="gene ID" value="CP523_13640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60775">
        <property type="protein sequence ID" value="QAS60775"/>
        <property type="gene ID" value="EI377_08530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="230" mass="24653" checksum="098AAD2CA9CE3461" modified="2018-12-05" version="1">MMYSREVEEMCVVAKGPNHGPAPIPVEGRWVQSKEVKDISGLTHGVGWCAPQQGACKLTLNVKDGIIEEALVETIGCSGMTHSAAMASEILPGKTILEALNTDLVCDAINTAMRELFLQIVYGRTQTAFSEGGLPIGAGLEDLGKGLRSQVGTMYGTVAKGPRYLEMAEGYVTETALDADGEIIGYKFVHLGKMMEMIAKGMDANEALVKATGQYGRFDDAVTVIDPRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL47</accession>
    <name>A0A386PL47_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13975</name>
        <name evidence="3" type="ORF">EI377_08865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678824.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35446">
        <property type="protein sequence ID" value="AYE35446"/>
        <property type="gene ID" value="CP523_13975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60833">
        <property type="protein sequence ID" value="QAS60833"/>
        <property type="gene ID" value="EI377_08865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="32340" checksum="D63EFC9B76D2A91F" modified="2018-12-05" version="1">MKIKKTTIAFLLLSVILLFAIVVSVYFILGSTSREIKVTKEFIEVLQSENAIDNSVNANKMEYKPLKTELNNNSNIKYTVATGNYGVDLDKDYNVIGFSKKEIKQVNSRSIAIKEEMAITLAEKYIKSISNEEVKLKEIRKPDDDMVQFYTVVFYKFKDGYPYYDYEIVAKINKITGELDGYSNSFLNDIKHTSDINIKYDKANEIANEYFSKLNIKVNIKQEPLLAYVKTKDDNRSELAYIFTVEINSKEILGKKNKLFISANSGEVISIGNDEVEKKEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL53</accession>
    <name>A0A386PL53_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">V-type ATP synthase subunit C</fullName>
            <ecNumber evidence="5">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12000</name>
        <name evidence="5" type="ORF">EI377_06820</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673469.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02957"/>
    <dbReference type="EnsemblBacteria" id="AYE35079">
        <property type="protein sequence ID" value="AYE35079"/>
        <property type="gene ID" value="CP523_12000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60472">
        <property type="protein sequence ID" value="QAS60472"/>
        <property type="gene ID" value="EI377_06820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_suC/d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="333" mass="38554" checksum="62254E90C031BA9A" modified="2018-12-05" version="1">MDVMQFTQALSRIWVLETRLLDKSKIERMIDADSADEALKVLGETEYSNVMTNIKRATDYEEILTAELKRIYDLVKELCPVKDVVKLMSIKYDYHNLKVILKGKFLGKDLSHMLIHLGDLDLHEVKRKIDSENYKELEAKLEKAVVEAANDFESTKDPQKIDIIIDRYMFKEMVELKNELDYEFIDKFVKAIIDSTNVRTLLRIKKQNKNREFALEVLVPGGSIDPSTLVALINESPENIISKLNSTIYSEMIKEGIEAYINTDSVNLLEKLSDNYIMALMKDSKLVTFGPERILSYIYAKETEIKIIRIIMVGKLNNIAEEVIKERLRDIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL65</accession>
    <name>A0A386PL65_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein MutT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12110</name>
        <name evidence="5" type="ORF">EI377_06940</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02979"/>
    <dbReference type="EnsemblBacteria" id="AYE35099">
        <property type="protein sequence ID" value="AYE35099"/>
        <property type="gene ID" value="CP523_12110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60492">
        <property type="protein sequence ID" value="QAS60492"/>
        <property type="gene ID" value="EI377_06940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="22418" checksum="10EE123DE56680AB" modified="2018-12-05" version="1">MSKVKINKVDILSDTKYLKLYNAEYCNKNGDLRNWTIASRKDLETIRNQFFNGLEEKIDAVIILAKHIKEDKLVIIKQFRVPLNDYVYELPAGLVDAGEDFTETVKRELKEETGLDLIEIDYTKTKSKVYVSVGMTDESVAFVYCTCSGEISKDNLEADEDIEVMLVNKDEAKKVIESNEKIDIKALLAIQNFIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL68</accession>
    <name>A0A386PL68_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell division protein FtsK</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">DNA translocase FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_00615</name>
        <name evidence="12" type="ORF">EI377_11105</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00654"/>
    <dbReference type="EnsemblBacteria" id="AYE35788">
        <property type="protein sequence ID" value="AYE35788"/>
        <property type="gene ID" value="CP523_00615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62208">
        <property type="protein sequence ID" value="QAS62208"/>
        <property type="gene ID" value="EI377_11105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="10">
        <location>
            <begin position="478"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="495"/>
            <end position="502"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="817" mass="91095" checksum="3FE866324F5D6C8D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLC6</accession>
    <name>A0A386PLC6_CLOSE</name>
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        <submittedName>
            <fullName evidence="9">Aminopeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">M42 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12635</name>
        <name evidence="10" type="ORF">EI377_07540</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675222.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01984"/>
    <dbReference type="EnsemblBacteria" id="AYE35199">
        <property type="protein sequence ID" value="AYE35199"/>
        <property type="gene ID" value="CP523_12635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60602">
        <property type="protein sequence ID" value="QAS60602"/>
        <property type="gene ID" value="EI377_07540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
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    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="242"/>
        </location>
        <ligand>
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            <label>1</label>
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        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="345" mass="38123" checksum="0452A906C613F94E" modified="2018-12-05" version="1">MNLQINKEFVLKTAKELLEFDSPSGFCFDIMKVIEKLSRDFGYEFETTRKGCGIITIKGQSDKEVVGLSAHVDTLGAMVRSITSNGTLKFTLIGCPIPATLDSEYCKIRTRGGKIYTGTFLSTSPAAHVYEDSKDKKRDPKNMEIRIDEIVSTKEEVKLLGIESGDFIFIDPKTTITESGFIKSRFIDDKGSVAALMGLLELFNRGNIVPKFKTKILISTYEEVGHGASYIPQDITEMISVDMGCIGEDLNCTEYDVSICAKDSGGPYDYNMVTKLVNLSQENNLKYAVDIYPMYGSDVGAALRGGNNIRGALIGPGVHASHGMERTHYTALENTIKLLYLYLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLF1</accession>
    <name>A0A386PLF1_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12850</name>
        <name evidence="3" type="ORF">EI377_07720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03041"/>
    <dbReference type="EnsemblBacteria" id="AYE35239">
        <property type="protein sequence ID" value="AYE35239"/>
        <property type="gene ID" value="CP523_12850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60633">
        <property type="protein sequence ID" value="QAS60633"/>
        <property type="gene ID" value="EI377_07720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="16856" checksum="5C7D39EA68ACBEF3" modified="2018-12-05" version="1">MDTVDLTKLSDALFKMLFQLNKKVFNQDEIIKGFPMPPSHVKVIFHLAHTGPSSVSQIAKTLYISKPNMTPIIDKLISEDFVTRYEDPNDRRIIRVELTKKAKDLFKAQKQKIKDMLQVKVSTLPEEDLITLESSVQNLTKIISKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLG3</accession>
    <name>A0A386PLG3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12955</name>
        <name evidence="2" type="ORF">EI377_07835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678211.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03021"/>
    <dbReference type="EnsemblBacteria" id="AYE35259">
        <property type="protein sequence ID" value="AYE35259"/>
        <property type="gene ID" value="CP523_12955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60654">
        <property type="protein sequence ID" value="QAS60654"/>
        <property type="gene ID" value="EI377_07835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="200" mass="23423" checksum="3747D05ABB809014" modified="2018-12-05" version="1">MYKLELYMLRHGKTIFNEERLYCGTSNPSLSEEGRSELIKLLKDIKYPQCNEYFTSGATRANETFEILYPNEQYEVISGFSEYDFGDFEGKSYEMLKKEKAYIDWITDDLGDVHCPNGESKKIYINRIVNTFKNFIRNCKVKKLQSVMLVSHGGTIGTILELFYDKRKSFYQWQPECGKGYKLTILVSDEIKVEKVEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLQ5</accession>
    <name>A0A386PLQ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15555</name>
        <name evidence="3" type="ORF">EI377_10270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678695.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35736">
        <property type="protein sequence ID" value="AYE35736"/>
        <property type="gene ID" value="CP523_15555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61075">
        <property type="protein sequence ID" value="QAS61075"/>
        <property type="gene ID" value="EI377_10270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="172" mass="17903" checksum="21C034B53317B81F" modified="2018-12-05" version="1">MNFKTKRLVVIALLAAMCYVGTFINIRIPIGGSMSMVHLGTTAIFIAAVLIGKDAGLAGGIGCALFDLLSDFVAWTIPTLIVKGLTGYVAGKISFANGKEGNSFKYNIAGFIVGGLVSLIGYFISNLLIFGKTWAVAVTSLSTSLVTTTIGVIIAVPLATAVKKVVKKSNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLZ0</accession>
    <name>A0A386PLZ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14700</name>
        <name evidence="2" type="ORF">EI377_09665</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678846.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00134"/>
    <dbReference type="EnsemblBacteria" id="AYE35579">
        <property type="protein sequence ID" value="AYE35579"/>
        <property type="gene ID" value="CP523_14700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60965">
        <property type="protein sequence ID" value="QAS60965"/>
        <property type="gene ID" value="EI377_09665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="244" mass="28584" checksum="FBCB2DA393B8E4B0" modified="2018-12-05" version="1">MKKTIYDYIDSIKKLPIKDKYLKEDILIEDFLVNECDNIKVYYAPHNEYINYKAKIFIVGITPGFQQMSTSIKEARILLEENENIEVIQYKCKVKGRFSGSLRKNIINMLDYIKLNHALNLKSCSELFYEKDYLLHTFSLIPYSVFVKGKNYTGHTPKLINNKFLMSYVYENFLCELNELENVIIIPLGKAVEEVLNKLSEENTINGDNILRGFPHPSGANVNRLIQLEEKKENMMKFIKNKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM85</accession>
    <name>A0A386PM85_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Repressor LexA</fullName>
            <ecNumber evidence="15">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lexA</name>
        <name evidence="14" type="ORF">CP523_15730</name>
        <name evidence="15" type="ORF">EI377_10445</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="15"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678902.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00106"/>
    <dbReference type="EnsemblBacteria" id="AYE35769">
        <property type="protein sequence ID" value="AYE35769"/>
        <property type="gene ID" value="CP523_15730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61107">
        <property type="protein sequence ID" value="QAS61107"/>
        <property type="gene ID" value="EI377_10445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0742">SOS response</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="13">
        <location>
            <begin position="352"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="473" mass="54649" checksum="C69F273C92666A82" modified="2018-12-05" version="1">MEFSKVQSKFINQKSVGYKILKGKNGTGKSTTSIYKAINLENNYCIYEEDSILFISSDKFNRDKVISLYNIEKNKNHFYSLFSLDKGRFESNVLNDMILNYSKAYRMENSINETYIDNENILKIKNYLYPKIKDLSKKYKILRKMDYDFILDEILWIRACDFTLDEYLIIDRKGRGKRINKNSNSRKVIYSIKDAYVNILKDNNYSDRFNDVLYAKNYVKKHNIKYTHIILDDSEKLSRSEIDFVKSIYKNNPYSSLIFIVNSELCNEKYSWLVKGRKLKTLGEDFKGKTFLYKTIFNNKEIIMPKTIDTYRYLNIKNKTEANFDIDTSAVEKEILLKDGLSFKEDELLDIPIFNDIAAGSPIEMNGSVEGDFSLPKSWIGRGSDTFILKVKGDSMINKDICDGDFVVIRKQSTANNNDIVAASLDGEATLKILNTNGEEPVLTPANPLYTNITLRDKDVNILGIAIGVIKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAL6</accession>
    <name>A0A386PAL6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="6">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="6">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="6">IPP transferase</shortName>
            <shortName evidence="6">IPPT</shortName>
            <shortName evidence="6">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">miaA</name>
        <name evidence="10" type="ORF">CP523_00155</name>
        <name evidence="11" type="ORF">EI377_10740</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6 8">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6 9">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677400.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01201"/>
    <dbReference type="EnsemblBacteria" id="AYE32973">
        <property type="protein sequence ID" value="AYE32973"/>
        <property type="gene ID" value="CP523_00155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61159">
        <property type="protein sequence ID" value="QAS61159"/>
        <property type="gene ID" value="EI377_10740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE32973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="308" mass="35620" checksum="9204C433CDDF27F9" modified="2018-12-05" version="1">MKEKILVLAGPTAVGKTELSIKLAKKLNGEIISTDSMQIYKHMDIGSAKISENEMDGIKHHMIDIVEPDTEFSVSDYKEMASKCIDDIISRGKVPILTGGTGLYINALTCNMNFTEAGNDKEYREYLEKLADEKGNKFIHNNLKDIDPISFKEIHYNNRKRVIRALEVYKLTGKPFSSFNAGDDFYKSKYDVFYYVLNMNREKLYNRINKRVDIMMEKGLLEECIKLKEMGYNSSIQSMQGIGYKEILYHLEEGLSLEVAIDMVKQGSRNYAKRQITWFKRDPRAKFKDKDILSDDDIFSEIIREFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAR4</accession>
    <name>A0A386PAR4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore coat associated protein CotJA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00330</name>
        <name evidence="2" type="ORF">EI377_10820</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33005">
        <property type="protein sequence ID" value="AYE33005"/>
        <property type="gene ID" value="CP523_00330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61173">
        <property type="protein sequence ID" value="QAS61173"/>
        <property type="gene ID" value="EI377_10820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020256">
        <property type="entry name" value="Spore_coat_CotJA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11007">
        <property type="entry name" value="CotJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="51" mass="6065" checksum="586D5E78285880A3" modified="2018-12-05" version="1">MNIEENLIRNNEYAKAYIILQKYENLLTPATALNIGTIFRDLYRPYIESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBK8</accession>
    <name>A0A386PBK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FeoB-associated Cys-rich membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01980</name>
        <name evidence="2" type="ORF">EI377_12500</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33315">
        <property type="protein sequence ID" value="AYE33315"/>
        <property type="gene ID" value="CP523_01980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61485">
        <property type="protein sequence ID" value="QAS61485"/>
        <property type="gene ID" value="EI377_12500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="49" mass="5400" checksum="99B56B9902935AE6" modified="2018-12-05" version="1">MEIVITVAIIGFSAYIIYKNVRKSSKGGCNCGNCSSHCPMYNDKNKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBP2</accession>
    <name>A0A386PBP2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">miaB</name>
        <name evidence="13" type="ORF">CP523_00125</name>
        <name evidence="14" type="ORF">EI377_10775</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677408.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01207"/>
    <dbReference type="EnsemblBacteria" id="AYE32967">
        <property type="protein sequence ID" value="AYE32967"/>
        <property type="gene ID" value="CP523_00125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61165">
        <property type="protein sequence ID" value="QAS61165"/>
        <property type="gene ID" value="EI377_10775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="148"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="381"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="443" mass="50447" checksum="53CF9EC188F023DD" modified="2018-12-05" version="1">MLENKELKYYIETWGCQMNEEDSEKLSGMLKRSGYSETETQEEADIIIYNTCCVRENAENKVFGNLGQLKHLKKKKPNLIIAVCGCMMQQEGMADKILKTFPHVNIIFGTHNAYKFPEYLNRVKTEGVQVKEIFNKETEIIEGLPIDRKSDVKAFVTIMYGCNNFCTYCIVPYVRGRERSRKSEDIIKEIEDLVSSGYKEVTLLGQNVNSYGKGLEEEITFAGLLRKINEIPGLERLRFMTSHPKDLNKDVVLAIKECDKLCEQVHLPVQSGSNKILKKMNRNYTKESYLELINMIKAEIPDVTITTDIIVGFPGETEEDFLETLELAKEVEYSSAFTFIYSRRNNTPADMMLNQVPDEAKHERFNRLVEVINAGVIKGNKEYEGKVVEVLVEGPSKNDETKLTGRTRNGRLVNFEGKDVSAGDLVNVKIVRAQPFSLIGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBQ2</accession>
    <name>A0A386PBQ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">lexA</name>
        <name evidence="16" type="ORF">CP523_00175</name>
        <name evidence="17" type="ORF">EI377_10720</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677393.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01197"/>
    <dbReference type="EnsemblBacteria" id="AYE32977">
        <property type="protein sequence ID" value="AYE32977"/>
        <property type="gene ID" value="CP523_00175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61155">
        <property type="protein sequence ID" value="QAS61155"/>
        <property type="gene ID" value="EI377_10720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="85"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="204" mass="23014" checksum="450197E81F8E40FD" modified="2018-12-05" version="1">MSDSTKVKDKQLEIYEFLKLYIENKGYPPSVREICSAVSLKSTSTVHSYLKKLENNGLIRRDPTKPRALEILGDTLNKREMLNIPIIGRVTAGVPILATENIEDTFPIPIDYIKHNDELFILRVTGESMINAGINDKDLAIIEKASTAKDGDIVVALIDNEATIKRFFKEKDHIRLQPENDNMEPIIVDNCSILGKLIGLFRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBU4</accession>
    <name>A0A386PBU4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar biosynthesis protein FlhF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flagella-associated GTP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">flhF</name>
        <name evidence="13" type="ORF">CP523_02525</name>
        <name evidence="14" type="ORF">EI377_13060</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673939.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00462"/>
    <dbReference type="EnsemblBacteria" id="AYE33415">
        <property type="protein sequence ID" value="AYE33415"/>
        <property type="gene ID" value="CP523_02525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61589">
        <property type="protein sequence ID" value="QAS61589"/>
        <property type="gene ID" value="EI377_13060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020006">
        <property type="entry name" value="FlhF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF3">
        <property type="entry name" value="PTHR43134:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03499">
        <property type="entry name" value="FlhF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="190"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="12">
        <location>
            <begin position="191"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="387" mass="43752" checksum="2D513D747F8E48B1" modified="2018-12-05" version="1">MIIKKYLAKNMNEALIKIRSELGKDAIIISQRKVRAAGVKGYFSPKIIEITAAIENSKTPAKSEGRKYTKSSNDFNESLEDFKKLIQKGQDGLKAKNIEQQVHKPENKQENKLEKSELDSEVKEIKNLLSKVIKNTEKEEDLILKKLKDIDIDEVFFEEIREQCSDDVKNFEEDFNKVLSKDIHIWDGDLNGKVVLVGPTGVGKTTTIAKLAGRLSLIDKKKVGLITIDTYRIGAVEQLKTYAEIMGIPFRVVITLKEMEQAIKDLEDCDVVLIDTTGRSSKNYMQISELRAYVNKVNADHTALVVSSTTKNRDLDVIIKGYSEIGYDKIIITKLDETRAYGSIYNICKKSNSKIAYITTGQNVPDDIKRPKIEELKKIVLGEENLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBW4</accession>
    <name>A0A386PBW4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01620</name>
        <name evidence="2" type="ORF">EI377_12145</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675685.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00877"/>
    <dbReference type="EnsemblBacteria" id="AYE33250">
        <property type="protein sequence ID" value="AYE33250"/>
        <property type="gene ID" value="CP523_01620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61422">
        <property type="protein sequence ID" value="QAS61422"/>
        <property type="gene ID" value="EI377_12145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="376" mass="43065" checksum="9AFB2C877934F025" modified="2018-12-05" version="1">MFIKSCNNQNKELTLSIYNNNVALVNELRDLFKGKVINTIEYCDISKFIYENSVIIENVEVSQLNFNYKCCNNDKNKSENSSCNDCLSSFVNSIDIEVDSINSKNIRVYYLTAGVKWDSSYTLILNENKLSMQSWINISNKSGISYNHANLKCISGEVNFDSLSPIPYSKTSYANSEAVENPKLQPLDDYYIYNLSGKYILENNSTKRIKNFSAENIEYTKLYDFGYYNTNADILIKLNNTEDNNLGIPMPSGTVNIYASLNDSLQFLGSDSIKNTPINQELNLNIGKAFDITCERKIINYQKYDNYEFKEIELIINNSKDEDVPIKICYPIFAPWEITSTTDNYEKDSNGNPCFKVKVSANSKKRILFTYKTKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC62</accession>
    <name>A0A386PC62_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hemC</name>
        <name evidence="9" type="ORF">CP523_03200</name>
        <name evidence="10" type="ORF">EI377_13715</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677256.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02143"/>
    <dbReference type="EnsemblBacteria" id="AYE33543">
        <property type="protein sequence ID" value="AYE33543"/>
        <property type="gene ID" value="CP523_03200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61706">
        <property type="protein sequence ID" value="QAS61706"/>
        <property type="gene ID" value="EI377_13715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="222"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="32055" checksum="6E862FEB2559FFFD" modified="2018-12-05" version="1">MELIIATRKSKLAQVQADKVIDLIKEKQGVDSKKLLVVTEGDRRLDVSLNKIGGKGLFVKEIELAILNNEAHAAVHSMKDVPFELPEDFELIAMPEREDIRDAFISPNGIKINELKIGARVGTSSIRRAAQLKEIRPDLDIVSIRGNVQTRLLKMEQERLDGIILAGAGLKRLGMENIITDYFDPKVFLPAIGQGALGIECLKNGVYNKYFKALDSKDVRITVDAERSFMKALNGGCHTLIGAYTEVKGNDLYMIGTFSVGDKIVKKDILGNKEENILLGIKLAEKILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC93</accession>
    <name>A0A386PC93_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smc</name>
        <name evidence="5" type="ORF">CP523_00825</name>
        <name evidence="6" type="ORF">EI377_11320</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674594.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02355"/>
    <dbReference type="EnsemblBacteria" id="AYE33097">
        <property type="protein sequence ID" value="AYE33097"/>
        <property type="gene ID" value="CP523_00825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61267">
        <property type="protein sequence ID" value="QAS61267"/>
        <property type="gene ID" value="EI377_11320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="525"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="689"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="839"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1187" mass="136019" checksum="68F30657064353B3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCF7</accession>
    <name>A0A386PCF7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03745</name>
        <name evidence="8" type="ORF">EI377_14275</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675387.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01463"/>
    <dbReference type="EnsemblBacteria" id="AYE33643">
        <property type="protein sequence ID" value="AYE33643"/>
        <property type="gene ID" value="CP523_03745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61807">
        <property type="protein sequence ID" value="QAS61807"/>
        <property type="gene ID" value="EI377_14275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="345"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="416"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="659"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="702" mass="78358" checksum="4B5D99ABFDCDCD04" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCI3</accession>
    <name>A0A386PCI3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03865</name>
        <name evidence="6" type="ORF">EI377_14400</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675501.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01545"/>
    <dbReference type="EnsemblBacteria" id="AYE33665">
        <property type="protein sequence ID" value="AYE33665"/>
        <property type="gene ID" value="CP523_03865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61827">
        <property type="protein sequence ID" value="QAS61827"/>
        <property type="gene ID" value="EI377_14400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="24945" checksum="5A26FE9AA1F79E08" modified="2018-12-05" version="1">MIELKNISKIYGEKESITKALDNINLKIHNGDFISIMGPSGCGKSTLLNILGCLDTQSKGEYIFKNNNISDKTEKQLAFIRNREFSFIFQNFSLIKELNVIQNIILPLEFSGKRKVDYKKINEYMDDLGILELKERKIYTLSGGQQQRVAIARALVQESNVILADEPTGALDQSNSIVITQILKMLNEKYNKTIILVTHDKNVASCANKIIEMRDGKILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCK2</accession>
    <name>A0A386PCK2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04010</name>
        <name evidence="5" type="ORF">EI377_14530</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676933.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02784"/>
    <dbReference type="EnsemblBacteria" id="AYE33693">
        <property type="protein sequence ID" value="AYE33693"/>
        <property type="gene ID" value="CP523_04010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61848">
        <property type="protein sequence ID" value="QAS61848"/>
        <property type="gene ID" value="EI377_14530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="153" mass="17458" checksum="B2A92B69A18937B0" modified="2018-12-05" version="1">MNLNIVLYQPEIPQNTGNIARTCVLTNSTLHLIKPMSFSIDDKHVKRAGLDYWKDLKLEIHESYEDFMKKYGNERIFLATTHGGVHYDEASFQQGDFIMFGRESSGVPEDVHNKHNGIRVPMIKSSTRSLNISNTVAIVAYEALRQIGFPEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCL9</accession>
    <name>A0A386PCL9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01500</name>
        <name evidence="3" type="ORF">EI377_12020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675633.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00852"/>
    <dbReference type="EnsemblBacteria" id="AYE33227">
        <property type="protein sequence ID" value="AYE33227"/>
        <property type="gene ID" value="CP523_01500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61399">
        <property type="protein sequence ID" value="QAS61399"/>
        <property type="gene ID" value="EI377_12020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="19408" checksum="198D45043134E534" modified="2018-12-05" version="1">MKINVSLRQEVYRDDAINLVKWLRDKEVTKYLNEDKYASENIENLLNTINIPILTHLFNNNGKFQIINNNKEAIGFVRLVPKGNNAEIVIAIGEKELWGKGYGKAAIIESLKQAFFDWRVDEVIAKIRTKNIRSRRAFESIGFKENKILQNEIIYTMSIYEFLKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCQ6</accession>
    <name>A0A386PCQ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">CP523_00860</name>
        <name evidence="9" type="ORF">EI377_11355</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674572.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02347"/>
    <dbReference type="EnsemblBacteria" id="AYE33104">
        <property type="protein sequence ID" value="AYE33104"/>
        <property type="gene ID" value="CP523_00860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61274">
        <property type="protein sequence ID" value="QAS61274"/>
        <property type="gene ID" value="EI377_11355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00860"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="332"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="400" mass="44072" checksum="6FD845EA6E9FAEF7" modified="2018-12-05" version="1">MKILVINCGSSSLKYQLIDMNTEESLAQGVVERIGLDGSILTQKVEGRDKYKIEKQMKDHKDAIKLVLEVLVDKEHGVIASMDEISAVGHRVVHGGEKYSKSVLVDNEVIKNIEECFKLAPLHNPPNMIGINACKELMPNTPMVVVFDTAFHQTMKEEAYIYALPYELYVNHSIRKYGFHGTSHKYVSEKVADVLGKNVKDLKIITCHLGNGASLCAVKNGISIDTSMGFTPLEGIVMGTRSGSIDPAIATYLIKECNYTADEVNDLLNKKSGVLGISGVSSDFRDIEIAAFEKNNKRAQLALDIFHYKIRAQIGAYAAIMGGVDVIVFTAGVGENSPETREECLKGLEFLGIELDKEKNNVRGKIREISKEGCKVKAFVIPTNEELMIARDTAELTKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCS3</accession>
    <name>A0A386PCS3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33765">
        <property type="protein sequence ID" value="AYE33765"/>
        <property type="gene ID" value="CP523_04390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024008">
        <property type="entry name" value="CHP04090"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023833">
        <property type="entry name" value="Signal_peptide_camelysin"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04088">
        <property type="entry name" value="cognate_SipW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04090">
        <property type="entry name" value="exp_by_SipW_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017450422" evidence="1">
        <location>
            <begin position="27"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="222" mass="23530" checksum="52E2C208C20A91D3" modified="2018-12-05" version="1">MIRRKSINRTILAVGAAAVLVGGTLAWFTSTDTVTNKFKTGGNGTGQSKGVEIWENFASDKALEVLPGTIIDKEVQAQNTATYNSLIRVKLTPTIISGSTTADVSNIRLIFSENVIKRGKSTEGNTNGKWLQGTDGYYYYLGNVAPNGYTTMLLKDVQLDKTAGNEFKDVTFDVVVNAESIQSDNGAYADAWKGAGQPVLDKLAIVAGQTAGTASQIPGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD02</accession>
    <name>A0A386PD02_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ybeY</name>
        <name evidence="8" type="ORF">CP523_02205</name>
        <name evidence="9" type="ORF">EI377_12725</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674038.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00526"/>
    <dbReference type="EnsemblBacteria" id="AYE33357">
        <property type="protein sequence ID" value="AYE33357"/>
        <property type="gene ID" value="CP523_02205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61527">
        <property type="protein sequence ID" value="QAS61527"/>
        <property type="gene ID" value="EI377_12725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="19983" checksum="BEE2FC7FD1183608" modified="2018-12-05" version="1">MLYTDNRQNKLEVNEEFINRISKVCDFALNEEGVDFEYQISLLFVDNEEIKEINNETRNIDKTTDVLSFPMLDYEKGKVFKDMYIGYDFDETYMDGEELVLGDIVLSLERALEQSKEFNHSYEREVCYLVIHSILHLLGYDHMEDEEKIVMRKREEEILNKLNITRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD44</accession>
    <name>A0A386PD44_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe-S_biosyn domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02435</name>
        <name evidence="3" type="ORF">EI377_12960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33397">
        <property type="protein sequence ID" value="AYE33397"/>
        <property type="gene ID" value="CP523_02435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61571">
        <property type="protein sequence ID" value="QAS61571"/>
        <property type="gene ID" value="EI377_12960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="91" mass="10522" checksum="8AC9E74AAFC2F87C" modified="2018-12-05" version="1">MNILFDEKAKEGLLELVNNGSNDYVRVKVAAVGCGKPAYDIYCDYKSQNDIEVEINSIKFVIDKKDERLCDNIEIKYDKDIYNNGFYIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD70</accession>
    <name>A0A386PD70_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_01755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02400"/>
    <dbReference type="EnsemblBacteria" id="AYE33274">
        <property type="protein sequence ID" value="AYE33274"/>
        <property type="gene ID" value="CP523_01755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="PTHR12872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017406017" evidence="8">
        <location>
            <begin position="32"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2186"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="27"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="914"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="1345"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="1519"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="10">
        <location>
            <begin position="2181"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2135"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2100"/>
            <end position="2127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2136"/>
            <end position="2185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="2214" mass="247029" checksum="7AA26A69AE81921F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD88</accession>
    <name>A0A386PD88_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33963">
        <property type="protein sequence ID" value="AYE33963"/>
        <property type="gene ID" value="CP523_05485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="252" mass="27884" checksum="E6729801A0362D14" modified="2018-12-05" version="1">MEHLPQIANQVKNGGKVEKIVESIKASKGAAEAIANAKYTRTLLQSMRGFMDDVASVVAKQGITIEKFTELRLKPLEKLTESEKSIMKVIRESISMPDNTTIMQKVIPKGDIAKYIDGTYTQVGGYVTKAQDVKQLKNYNNIYQSLRLDYPGTVYNQATDDVLGVIRFKTPQASNIKIPYGKEMGGSVTDSFPFTGNGFTSATNGQTIPEFTCNSRLNLYDGAELYEVGKDGREVLRAIFDDEIGKFVSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDI6</accession>
    <name>A0A386PDI6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">CP523_06065</name>
        <name evidence="9" type="ORF">EI377_00545</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675105.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01914"/>
    <dbReference type="EnsemblBacteria" id="AYE34065">
        <property type="protein sequence ID" value="AYE34065"/>
        <property type="gene ID" value="CP523_06065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59436">
        <property type="protein sequence ID" value="QAS59436"/>
        <property type="gene ID" value="EI377_00545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="188" mass="21673" checksum="9AAAB33FF6F2B26B" modified="2018-12-05" version="1">MLEKFQELLKSKSKEKSEKGKKSSNLTDYFKIIGLSLIVALLINKFLIFKAQIPTSSMVPTLNVGDVLLVNKLYNLDSLKRGDIVVFFSNENNEYMVKRLIGLPGDYVSINNGKVYVNGEYLEENYVKFEDEYIGSYTVPEDKYFFLGDNRPISLDSRRWKETCIDKKDIVGLVNFRLYPIKDIGNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDM2</accession>
    <name>A0A386PDM2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06275</name>
        <name evidence="4" type="ORF">EI377_00750</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02414"/>
    <dbReference type="EnsemblBacteria" id="AYE34105">
        <property type="protein sequence ID" value="AYE34105"/>
        <property type="gene ID" value="CP523_06275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59472">
        <property type="protein sequence ID" value="QAS59472"/>
        <property type="gene ID" value="EI377_00750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="395" mass="45097" checksum="A9F1DA1B71D29192" modified="2018-12-05" version="1">MCNNFLKDAISEYKTPFYVFDTDVLVDRIKKIKSVLGSDVELCYAMKANPFLIKSMEKVIDSFEVCSPGEFHICERADVPMDKVIMSGVYKNAEDVEYALLNYGNKVIYTVESLLQWKIIKEYVQKHNLSVRALLRLTIGNQFGMDEEDIRQIISDRDSYPYIEIEGIQFFSGTQKKSAAKMEKELSMLDDFCSVLENCYGFSAKRLEYGPGLPVYYFQEEENCEEEILNALANKISSMNFSGKIVLEVGRFIAASCGTYVTSIVDMKSNKKQNYCIVDGGIHHINYFGQMLAMKKPPIIHWSEQKDGDTKEWTICGSLCTMNDVLVKKYPFVNLQLGDKLIFKMVGAYSVSEGISLFLSRELPQVFLYSKNSGLSLARNNFPTDTLNYIQYKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDU5</accession>
    <name>A0A386PDU5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putrescine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">potE</name>
        <name evidence="9" type="ORF">CP523_03715</name>
        <name evidence="10" type="ORF">EI377_14245</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677687.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02202"/>
    <dbReference type="EnsemblBacteria" id="AYE33637">
        <property type="protein sequence ID" value="AYE33637"/>
        <property type="gene ID" value="CP523_03715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61801">
        <property type="protein sequence ID" value="QAS61801"/>
        <property type="gene ID" value="EI377_14245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015496">
        <property type="term" value="F:putrescine:ornithine antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02073">
        <property type="entry name" value="Putrescine_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004754">
        <property type="entry name" value="Amino_acid_antiprt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027566">
        <property type="entry name" value="Symport/antiport_PotE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00905">
        <property type="entry name" value="2A0302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04299">
        <property type="entry name" value="antiport_PotE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="452" mass="48436" checksum="A6793B03C170945A" modified="2018-12-05" version="1">MKKQKNKMSVMQLTMITAINMMGSGIIMLPTKLAEVGTMSILSWVVTGVGSMALAYVFAQCGMFSRKPGGMGGYAEYSHGKSGNFMANYSYGISLIIANIAIAISAVGYATVLFDVELSPVAVGLCTIFTLWLATVLNFGGASITGKLGSFTVWGVIIPVLVMSTVGWFWFSGADYVSSWNPNNFSFFDGIGKSISITLWAFLGLESASANMDAVDNPKKNVPIACLGGTIGAAIIYIVSTNVIAGIVPNADLLSSNAPFGLAFATMFSPMVGKIVMGMMIISCFGSLLGWQFTIAGVFRTSAIEGYFPKIFGKVTKNETPIIGMVIITIIQSLLALMTVSPSLSKQFDVLVNLAVVTNVIPYLLSMGAVNVILKSENVPEKKVKITTFISIIASIYSLYALYSSGVESMFYGSIVTFAGWVLYGFVSYRFDLKKDSEAEKVEVQSLNTIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDV2</accession>
    <name>A0A386PDV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase A8</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Signal peptidase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06825</name>
        <name evidence="8" type="ORF">EI377_01300</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00007"/>
    <dbReference type="EnsemblBacteria" id="AYE34195">
        <property type="protein sequence ID" value="AYE34195"/>
        <property type="gene ID" value="CP523_06825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59559">
        <property type="protein sequence ID" value="QAS59559"/>
        <property type="gene ID" value="EI377_01300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="28954" checksum="21FA106CC9C35547" modified="2018-12-05" version="1">MKQKLNKDKLITISLLPAMWLIYFLFEIFTGRVKDLYTLTLNLSLIFVFAFTGWIIYYSFEKNSKGLSFKNLSILFIILMIIDQGGKIIIKFFFFHKYFEIIPNFLSFNPIINSEGSWLNARFGFGVSFPILILVNALALFLFVELYRYYLNKGNKGFWSDMCFIFIFTGALCSLIDKVFYGGSLDFIGISNLFVADIKDIYINIGILFFIMCIYTSGYLSDNEDTTLKEDIQGIKKFLSFVKKDIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDV7</accession>
    <name>A0A386PDV7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3883 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01469"/>
    <dbReference type="EnsemblBacteria" id="AYE33647">
        <property type="protein sequence ID" value="AYE33647"/>
        <property type="gene ID" value="CP523_03770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3883" evidence="1">
        <location>
            <begin position="152"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="281" mass="33062" checksum="355EDB1B69E3AEC3" modified="2018-12-05" version="1">MIDDIIQIFKDNQNKWMTYKEVFNALNERKFNWGSNIKGSIGHKNIVSRELSERHRDKFEIDKRFRPQKYRLKNFNNKEIENEISIDLDINDNDGEDEITEFVLDIDNLEFKEYDSPSGIEIREPSVKIKEKGRKINYDKKSRRNKKKGDIGEEAVVLLEKNKLMELGRVDLSEQVEWVSKEKGDGLGYDIISWNVKDGEWNKIYIEVKTTEDNINTPFDISDTEVRVSEMLAENYYIYRVLGIGSVISTIKYYTIKGSVKDNFNLIPILYKAYLKTNENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE89</accession>
    <name>A0A386PE89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02175</name>
        <name evidence="4" type="ORF">EI377_12695</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674052.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00532"/>
    <dbReference type="EnsemblBacteria" id="AYE33351">
        <property type="protein sequence ID" value="AYE33351"/>
        <property type="gene ID" value="CP523_02175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61521">
        <property type="protein sequence ID" value="QAS61521"/>
        <property type="gene ID" value="EI377_12695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016842">
        <property type="entry name" value="UCP026546_HTH-CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026546">
        <property type="entry name" value="UCP026546_CBS_YqzB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="212" mass="23163" checksum="F8F29AE0FC26C9E2" modified="2018-12-05" version="1">MKLSQRQEEIIKIVKEGQPVTSESLAEKLGVTRAALRADLAILTMIGVLDARPKVGYVYQGEPHNTSILENISKVVAGEIMSKPVTVNEETTVYDAIVFLFLNDVGTLFVENNGMLLGAVSRKDFLKIAIGGTDIYKVPIGVIMTRMPNIVCGYSEDSAYSLAKKIIEHEIDSIPIVEKVESLDGGKNQLRIIGKISKTNITKLFVKLGEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM9</accession>
    <name>A0A386PEM9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LD-carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_08725</name>
        <name evidence="7" type="ORF">EI377_03475</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678054.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02686"/>
    <dbReference type="EnsemblBacteria" id="AYE34493">
        <property type="protein sequence ID" value="AYE34493"/>
        <property type="gene ID" value="CP523_08725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59895">
        <property type="protein sequence ID" value="QAS59895"/>
        <property type="gene ID" value="EI377_03475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="PTHR30237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="SSF141986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S66" evidence="4">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S66C" evidence="5">
        <location>
            <begin position="176"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR028757-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="34937" checksum="E2F954A9232D035B" modified="2018-12-05" version="1">MLKLNPLSPSSTIGIVAPASAEDPNIIDKKILEFEELGFNVKKGKHIYDKYGYLAGTDSNRAEDLMDMFIDNSIDAILCLRGGYGSMRMIPYLNLKTIKQNPKPFCGYSDITLLLNYISKKCNFATFHAPMITSNFKDSVTQDYFINTLTNHNMNFYNLKKISNNKITYINKNNFNGKLVGGNLSIICSSIGTPYELNFKNSIVLIEEIDESPYAIDRMLTQLIYSGKLKHSSGIILGDFTNCTSKNKNSAEFNIDEVINQKLSQLKIPVIKGFPIGHSYPNVTLPIGSKLSFNYKNDLLNISENIFKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN5</accession>
    <name>A0A386PEN5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcriptional regulator CtsR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_08785</name>
        <name evidence="11" type="ORF">EI377_03545</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the CtsR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678081.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02698"/>
    <dbReference type="EnsemblBacteria" id="AYE34505">
        <property type="protein sequence ID" value="AYE34505"/>
        <property type="gene ID" value="CP523_08785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59908">
        <property type="protein sequence ID" value="QAS59908"/>
        <property type="gene ID" value="EI377_03545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008463">
        <property type="entry name" value="CtsR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041473">
        <property type="entry name" value="CtsR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041908">
        <property type="entry name" value="CtsR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040465">
        <property type="entry name" value="CtsR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041902">
        <property type="entry name" value="CtsR_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40028">
        <property type="entry name" value="PTHR40028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05848">
        <property type="entry name" value="CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17727">
        <property type="entry name" value="CtsR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010607">
        <property type="entry name" value="Txn_repr_CtsR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CtsR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CtsR_C" evidence="9">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="151" mass="17341" checksum="5DA81822082B826C" modified="2018-12-05" version="1">MARISDTIESFIKDMINDRKENKILIQRNELADKFSCAPSQINYVLTTRFTYEKGYLIESKRGGGGYIIITKITYDNKERRLDLINNSIGDSITYQGAISILDHLIESKTITRKEYEIMKISLNDRTLTSVIDKNRVRADILKGMITIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02751"/>
    <dbReference type="EnsemblBacteria" id="AYE33724">
        <property type="protein sequence ID" value="AYE33724"/>
        <property type="gene ID" value="CP523_04165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="161" mass="18192" checksum="EB1EED29D98C74D4" modified="2018-12-05" version="1">MKKRTIIIYTIIILIIGLGIGVTVNSKTNFLGLLSGKSEREVISGYSFEKIKNNVINKEFDGKYLDPFVTIALEQDEFSINLKGIKKESKVFLIDPNTGEMKEIKNDNELFSITTKLEKDINYGIIVDYNLVGSIRVVQDFNSIDEGKFYRDILINLGCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV0</accession>
    <name>A0A386PEV0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03295</name>
        <name evidence="3" type="ORF">EI377_13810</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677224.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33561">
        <property type="protein sequence ID" value="AYE33561"/>
        <property type="gene ID" value="CP523_03295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61724">
        <property type="protein sequence ID" value="QAS61724"/>
        <property type="gene ID" value="EI377_13810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="126" mass="14597" checksum="88F20A68381884B3" modified="2018-12-05" version="1">MGKIVGCSVVIKDDFNNILIVQKKVKRNEPKLWYLVGRTLRGKESTEKCITRAVKDDLKVNIFDLQIIDEYKINDDENILLYTGNVKESINMGKDITSYKWIGIDNLNSYEFAEGEKERLLSCFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF20</accession>
    <name>A0A386PF20_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08155</name>
        <name evidence="6" type="ORF">EI377_02910</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674660.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01574"/>
    <dbReference type="EnsemblBacteria" id="AYE34400">
        <property type="protein sequence ID" value="AYE34400"/>
        <property type="gene ID" value="CP523_08155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59805">
        <property type="protein sequence ID" value="QAS59805"/>
        <property type="gene ID" value="EI377_02910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="139" mass="15580" checksum="7C1A94924F4DF0B9" modified="2018-12-05" version="1">MKIIYWSGTGNTEEMANLIAKGIEKGDKVAELIKVEDATLNTIKDEELIILGCSAMGDEVLEEYEMEPFIESISQEISGKKVALFGSYGWGDGKWMRDWEERMAEYGAQVIEESLIVNNFPADDDAEKCVEFGIKISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF56</accession>
    <name>A0A386PF56_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Zinc metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00950</name>
        <name evidence="3" type="ORF">EI377_11445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674527.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02329"/>
    <dbReference type="EnsemblBacteria" id="AYE33122">
        <property type="protein sequence ID" value="AYE33122"/>
        <property type="gene ID" value="CP523_00950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61292">
        <property type="protein sequence ID" value="QAS61292"/>
        <property type="gene ID" value="EI377_11445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="25564" checksum="311178B55AEC5CB5" modified="2018-12-05" version="1">MFYPGFYFDTTYLILIPAVIIAFWAQMKIDSTYKKYKDVRTVNGNTGSEIARNILDSAGLFDVRLERVNTNLGDHYDPTARVVRLSPEVYDGATIAAAGIAAHECGHAIQHQTSYKPLVLRTKIAPVVNIGSQLSIILFMIGIFFSSPMLAKIGIIFFGAAVIYQIVTLPVEFNASTRALSILKSRGFLYADEVKGAQKVLDAAAMTYVAATLMAISQLIRLIALNNRYNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA3</accession>
    <name>A0A386PFA3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ORF">CP523_10085</name>
        <name evidence="13" type="ORF">EI377_04885</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676584.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00346"/>
    <dbReference type="EnsemblBacteria" id="AYE34723">
        <property type="protein sequence ID" value="AYE34723"/>
        <property type="gene ID" value="CP523_10085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60124">
        <property type="protein sequence ID" value="QAS60124"/>
        <property type="gene ID" value="EI377_04885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10085"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="535" mass="60439" checksum="C2F611B9F4817176" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG9</accession>
    <name>A0A386PFG9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10485</name>
        <name evidence="4" type="ORF">EI377_05265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674213.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01403"/>
    <dbReference type="EnsemblBacteria" id="AYE34793">
        <property type="protein sequence ID" value="AYE34793"/>
        <property type="gene ID" value="CP523_10485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60188">
        <property type="protein sequence ID" value="QAS60188"/>
        <property type="gene ID" value="EI377_05265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="2">
        <location>
            <begin position="209"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="308" mass="35178" checksum="9C802DE502907576" modified="2018-12-05" version="1">MIYFKKFVCTKQYNSKILKNTLIRISLLILPICLFPTFIISYASTEPIPLSTPYPFIADKFNILDTRSKNSLPNRFRDIKDLNISGSAQFVPSQLDDIKEAVGTDNITIVDLRQESHGFVDDTAISFYSLFKLINSGLSSKETLKSEKKDLSSIAKEESLNLYSKSGEFKKTIEVKNVLSEGKAVKNANLNYVRFAVRDAKIPTPSTVDDFIEFIVNLDSNEHLHFHCHQGQGRTTTFMVLYQMMKNKNKIPLEDILKEQVTNGGVVLTDNKSRAKFLEYFYNYTLENMDSNYKTSYSSWLSSNKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN6</accession>
    <name>A0A386PFN6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="10" type="ORF">CP523_03985</name>
        <name evidence="11" type="ORF">EI377_14505</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679262.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01946"/>
    <dbReference type="EnsemblBacteria" id="AYE33688">
        <property type="protein sequence ID" value="AYE33688"/>
        <property type="gene ID" value="CP523_03985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61843">
        <property type="protein sequence ID" value="QAS61843"/>
        <property type="gene ID" value="EI377_14505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="332" mass="35819" checksum="623EB051437C3895" modified="2018-12-05" version="1">MVNVAINGFGRIGRLALRLMIENPEFNVVAINDLTDAKTLAHLFKYDSAQGRFNGEIQVKEGAFVVNGKEIKVTAERNPADLPWKELNVDVVLECTGFFTSQEKAGLHLEAGAKKVVISAPASGDIKTVVYNVNQEILDGSETVISGASCTTNCLAPMAKVLNDKFGIEKGFMTTIHAYTNDQNTLDGPHAKGDLRRARAAAASIVPNSTGAAKAIGLVIPELKGKLDGGAQRVPVITGSLTELVCNLEKKVTAEEINEAMKAAANESFGYTEEPLVSSDIIGISFGSLFDATQTKVMEVNGQQLVKVASWYDNEMSYTNQLIRTLKYFVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP0</accession>
    <name>A0A386PFP0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pfp</name>
        <name evidence="10" type="ORF">CP523_02900</name>
        <name evidence="11" type="ORF">EI377_13425</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677014.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00986"/>
    <dbReference type="EnsemblBacteria" id="AYE33486">
        <property type="protein sequence ID" value="AYE33486"/>
        <property type="gene ID" value="CP523_02900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61657">
        <property type="protein sequence ID" value="QAS61657"/>
        <property type="gene ID" value="EI377_13425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02900"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="6"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="405" mass="44776" checksum="B9470584218DCAC0" modified="2018-12-05" version="1">MANCIIAQSGGPTSVINSSVVGLLQANKDLKTFDKVYGGLNGIEGVLNGSLIELSSLNDDQIQSFRYTPSSGLGSCRYKMKKLEDSTEEYDRLLEILKFHNIKAFFYVGGNDSMDTTAKLGRYAKENGIDIKFIGIPKTIDNDLMFTDHTPGFGSAAKFIATSTLETYLDSSVYINNGIFILETMGRDTGWLAASACLAKIDGKQVADFIYLPEVAFDAIKFLNDVREKFKKQNKVFIVVSEGIRNKDGKFVTEAKDEVHDKFGHAQLGGVGSYLKHLIIDAGITKRVKSLELGVLQRCSIHCASDTDLTEAFDAGYAALKFAIEGNSGYMVAIKRDSNSPYSTSHFLIEADKVANNVKYFPIEWINHDGNNIKEEALNYFTPLVNGLPNLIFENTMPKFKTFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR0</accession>
    <name>A0A386PFR0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10950</name>
        <name evidence="3" type="ORF">EI377_05745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677655.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02524"/>
    <dbReference type="EnsemblBacteria" id="AYE34883">
        <property type="protein sequence ID" value="AYE34883"/>
        <property type="gene ID" value="CP523_10950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60278">
        <property type="protein sequence ID" value="QAS60278"/>
        <property type="gene ID" value="EI377_05745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="354" mass="41177" checksum="BFC8F660F7E381E2" modified="2018-12-05" version="1">MKINFVVPFLSLTGGLKIIFEYATRIKKKGNEVKIYVPYKPYKVYYKENKTIWLKQYIKNIINGNNIQWADFDLEIIPIPSIKERYIDDGDIIIATAWPTAYDVNNLSENKGKKVYFIQDYEIWHGDIEKVEQTYKFDMEQIVIAQWLKELVEKKNGNKKAHLIYNGIDLNEMYNNDKNYNLNSKNVVMLYHNLPSKGTNDGIEIINKIRKEDNSINLIMFGAEKGDNIPDYAEFYLLPERREIREIYSRGDVFLFTSISEGWGLTPLEAMACKCAVVGRDVGAIKEIGDNNKNVLKSNVEDVDSLEKNLIKVLNDINLRKTLSEEGYKLIKQFDWSKSVEKFYNVLEGTLDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU3</accession>
    <name>A0A386PFU3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfite reductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">asrC</name>
        <name evidence="8" type="ORF">CP523_03215</name>
        <name evidence="9" type="ORF">EI377_13730</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677250.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02140"/>
    <dbReference type="EnsemblBacteria" id="AYE33546">
        <property type="protein sequence ID" value="AYE33546"/>
        <property type="gene ID" value="CP523_03215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61709">
        <property type="protein sequence ID" value="QAS61709"/>
        <property type="gene ID" value="EI377_13730"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
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        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
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        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014261">
        <property type="entry name" value="Sulphite_reductase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
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        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02912">
        <property type="entry name" value="sulfite_red_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
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    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="320" mass="36140" checksum="5259C43F587BE951" modified="2018-12-05" version="1">MDINTKKLKKNAFRVTKRRGITSSRIRVPGGFLKAEYLGLIQEIAEKYGNGSVHITTRQGFEIPGIDMNNMEKVNELIQPIIEGLEINQEIPGKGYTSAGTRNVSACIGNNVCPYANYNTTNFAKKIEKAIFPNDLHFKIALTGCPNDCIKARMHDFGILGMTEPQFDRDKCISCGACVRACKKKSTEALHAENYRPVRDHSKCIGCGECVINCPTGAWTRSKEKYYRLAIMGRTGKKNPRLAEDFIVWVDEESIIKIILNTYKYVEQYIDRAAPGGKEHVGYIVDRTGFMEFKKWALEGVELSDKAILKENVYWNGIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX6</accession>
    <name>A0A386PFX6_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">Glycerophosphodiester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03385</name>
        <name evidence="3" type="ORF">EI377_13910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000064.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE33576">
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        <property type="gene ID" value="CP523_03385"/>
    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="238" mass="27691" checksum="40E0F401A9ABA2E8" modified="2018-12-05" version="1">MILNISHRGYSGKYDENTMIAFKKAIEFGADGIETDVQLSKDGIPVIIHDETLERTMNGKGFVKDYSLNELKSFRSKNNHEIPTLEELIILFKDSSLKVLNIELKNSIIKYHGLEEIVLDLIRKYNIENRVIISSFNHYSLLKVKALNKNIITGALTETTLVNVHEYLKNIKCECYHPYYYSIFDENIMNELKENYIKVNPYTINNKIDMKKAIEFGVTSIITNEIELLNELKYELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG20</accession>
    <name>A0A386PG20_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05470</name>
        <name evidence="4" type="ORF">EI377_16035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33961">
        <property type="protein sequence ID" value="AYE33961"/>
        <property type="gene ID" value="CP523_05470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62112">
        <property type="protein sequence ID" value="QAS62112"/>
        <property type="gene ID" value="EI377_16035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05470"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="110"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="192" mass="23106" checksum="9B4254B8F1143E9C" modified="2018-12-05" version="1">MTIIEVLSMYTKDYLSSNEFEQWVYQNEEKLNKSFDDSLYYEIIATDYNNKKEVINLKNKLEEYLNCNYTNEFNNINDCYIDKVIDTSEIENPIIKSLKERYRRKQNVEFDCININSLKELHQNIKDKFGFSQYYGMNWDALRDFLRETELPKQIIFNGWSHLLEIMPKDSNVLKEILVEYGSNDCEVIYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG29</accession>
    <name>A0A386PG29_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02875</name>
        <name evidence="2" type="ORF">EI377_13400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677007.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33482">
        <property type="protein sequence ID" value="AYE33482"/>
        <property type="gene ID" value="CP523_02875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61653">
        <property type="protein sequence ID" value="QAS61653"/>
        <property type="gene ID" value="EI377_13400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="131" mass="15251" checksum="CF46295CD1C0ED51" modified="2018-12-05" version="1">MSKKVSRKVLKMKRKERLKHRRKKFFIAISIGIAILLSSTFLIYTLIINNKLKDLNYAIDYHFTSRNIKSDRLLRVQQYDLLFADGDNVIVEAHGLSHEEPHAESSVKAKLTKNKKGIWELNKETLVANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG81</accession>
    <name>A0A386PG81_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobA</name>
        <name evidence="9" type="ORF">CP523_03195</name>
        <name evidence="10" type="ORF">EI377_13710</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677258.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02144"/>
    <dbReference type="EnsemblBacteria" id="AYE33542">
        <property type="protein sequence ID" value="AYE33542"/>
        <property type="gene ID" value="CP523_03195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61705">
        <property type="protein sequence ID" value="QAS61705"/>
        <property type="gene ID" value="EI377_13710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="8">
        <location>
            <begin position="264"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="489" mass="54566" checksum="9406A7CA83D86120" modified="2018-12-05" version="1">MSKVYIIGTGPGNEELLTLKAVDVLKRCTAVLYDRLVSNNILNYLSEDCEIYYCGKEPGCHYKTQEEINDMLIELAKKGHIVGRIKGGDPYVFGRGGEEVIALAEENIDFEVVPGVTSPISVLNYAGIPITQRGIAQSFHIVTGMTAGVLNINWEALAKEKGTLVFMMGLSNLDKIVGNLISNGKDRKTPAAVVMRGTSSKQRKVIGTLDNIEEIAKEAGFRSPCIIVVGEVVTLNDKLSWYEEKPLFGSNICVTRSREQSSNLKCKLRDLGAEVTEINSIKIEGTKENLEGYLDKLDKYNHILLTSVNGVNMFFDYLIEKKYDIRNIDAKFSVVGKATKKALENRGIMAFVMAKEFVGEGLFRALKPYLNKGEKVLIPCSSSSREYLKDEIEKLGLEVDRVNTYNTKCGDVKNNKAFEEVDIVLYTSPSTVKNMINMFGIEKIKEKKNIAIGPQTFKTLEENNIKSHMCKKHSEDGFLKEITDIYKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF7</accession>
    <name>A0A386PGF7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_05445</name>
        <name evidence="7" type="ORF">EI377_16005</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02579"/>
    <dbReference type="EnsemblBacteria" id="AYE33958">
        <property type="protein sequence ID" value="AYE33958"/>
        <property type="gene ID" value="CP523_05445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62109">
        <property type="protein sequence ID" value="QAS62109"/>
        <property type="gene ID" value="EI377_16005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="515"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1043" mass="120476" checksum="0275D4FD9796BC2D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH6</accession>
    <name>A0A386PGH6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2142 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02521"/>
    <dbReference type="EnsemblBacteria" id="AYE34880">
        <property type="protein sequence ID" value="AYE34880"/>
        <property type="gene ID" value="CP523_10935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018674">
        <property type="entry name" value="DUF2142_membrane"/>
    </dbReference>
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        <property type="entry name" value="DUF2142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="506" mass="58030" checksum="FABDD5FBCC93933A" modified="2018-12-05" version="1">MLILMYKSIMHFKNLEAYKSKGFLLISVVLVGLMIISMITLTKFNSKSIEKQFLVVGLIWGMAFIFINPPYLVPDESVHIYRAYDIAKGRLFFKGSENNMMLPVGVKKYDKQLWDIINNGKGSKNYIQNINTPLEKDNLIKYDADATAAYNTIAYIPQSIGMFIGDLLNLSSYFIIILGRISNFLTWLALCYLALKYIPIKKDLLFLLMCIPMGMQQAASTSPDALLNSSSFLLIAYILYLKFEKEKVDYKDVGIIILLTIIIGSIKLPYIAIGGILILIPNNKMKFKSFGKIMLIILIAFSSLAVKSGWEKISAPKIENSVVMEDSSSQKNNVEEKKEVISLAGTAKNILKEPGLFINKIIYTFKQDRDFYKASFTAYFGWFKVLAPNWTINLILLMLFIFAIKGDEKFKFKIFDKIILILMSIGMYAALCGVSLQWKQVPVHQVDVLDGIQGRYFFPFIIGIYFVFQNTKLKLKLNEFWLNSYRNIYLCWTLMFSLAMMFQTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL7</accession>
    <name>A0A386PGL7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05825</name>
        <name evidence="3" type="ORF">EI377_00310</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE34018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34018">
        <property type="protein sequence ID" value="AYE34018"/>
        <property type="gene ID" value="CP523_05825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59390">
        <property type="protein sequence ID" value="QAS59390"/>
        <property type="gene ID" value="EI377_00310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="69" mass="7861" checksum="1468289154D5DFAE" modified="2018-12-05" version="1">MDKKYTTYLPTERTNYKPPKHALESHGKTSGVTKLPSNVEDPIVVNNIANMEFDYTEHVDVDKDLNVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM5</accession>
    <name>A0A386PGM5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12825</name>
        <name evidence="3" type="ORF">EI377_07700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678200.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35235">
        <property type="protein sequence ID" value="AYE35235"/>
        <property type="gene ID" value="CP523_12825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60630">
        <property type="protein sequence ID" value="QAS60630"/>
        <property type="gene ID" value="EI377_07700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="120"/>
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    </feature>
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            <end position="161"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="284" mass="31446" checksum="CD0FD32C3079ACB2" modified="2018-12-05" version="1">MKGRVKSFFAAVGYSFLCALLQGIVSIIIIIPIVLSSAPINNFSPDNITNLIAPFMNYILMASSIVTMLTLWIIFKCRKLNLKEEILLKKTKSCNIIGAIILGFFAWIFNSSWVGFLQTLDQFKEAFNVMDQMLSGVGSGNIFVAILVVGIIAPIAEEFIFRGVIYRALKKNMSIVSTIIIQAILFGIFHGNLIQGMYTIPLALVLGYVTYRTNSLLPAIMIHIVNNTAATVMPMFLTGVDITMPLVIILFILGLLGVILPLRFIIKKNPKKIDSYTNINTSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS9</accession>
    <name>A0A386PGS9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00266 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13035</name>
        <name evidence="2" type="ORF">EI377_07910</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677828.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35273">
        <property type="protein sequence ID" value="AYE35273"/>
        <property type="gene ID" value="CP523_13035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60668">
        <property type="protein sequence ID" value="QAS60668"/>
        <property type="gene ID" value="EI377_07910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13035"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="217" mass="23610" checksum="1C179655619F7347" modified="2018-12-05" version="1">MSTKFELLYGNTNKVLKINAKQGEKYIVESAAMVSMDDVFNTKAKTGGLSKTLGRIFSGESMFIQEFTAKENGELLLAPKFLGDIEIVELNGEKRYRLGKSSFLAATEGIDVNTKSGGINGMLSGEGLIQMEASGAGTLFISAYGAIHKKVVAENETYIVDSDHLVLWDSNMRYSTELISGLFGSIAGGEGLVCKFNGPGEIWIQTRNPKNMFKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH01</accession>
    <name>A0A386PH01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06610</name>
        <name evidence="2" type="ORF">EI377_01100</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677489.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02200"/>
    <dbReference type="EnsemblBacteria" id="AYE34168">
        <property type="protein sequence ID" value="AYE34168"/>
        <property type="gene ID" value="CP523_06610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59536">
        <property type="protein sequence ID" value="QAS59536"/>
        <property type="gene ID" value="EI377_01100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
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        <property type="entry name" value="HAD_2"/>
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    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
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        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="24392" checksum="C572F593226C4D09" modified="2018-12-05" version="1">MQNIKAAIFDLDGTLVDSMWVWEQIDIDYLSAIGHKVPNNLKDEITHLSFNETALYFKNRFKLENSVEEIINSWNTMALDYYSNKIKLKKGVSEYLNKLKDNNIKIALATSNSTPLLEATLRNNGIYHYFDAITTTDEVKRNKAYPDVYLLSANKLNISPKDCVVFEDIVQAINGAKLAGMKVIAVYDKSSENQKEELMKLSDKYINDYTELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH27</accession>
    <name>A0A386PH27_CLOSE</name>
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        <submittedName>
            <fullName evidence="10">FtsX-like permease family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Macrolide ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_02920</name>
        <name evidence="10" type="ORF">EI377_13445</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677020.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00990"/>
    <dbReference type="EnsemblBacteria" id="AYE33489">
        <property type="protein sequence ID" value="AYE33489"/>
        <property type="gene ID" value="CP523_02920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61660">
        <property type="protein sequence ID" value="QAS61660"/>
        <property type="gene ID" value="EI377_13445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="305"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="399" mass="43407" checksum="DF00FBFDBD54B05B" modified="2018-12-05" version="1">MRENFKMAIESIKSNKLRSFLTMLGIIIGVSSVITIISLGKGGKEVVTGKLEKIGSSTVQIKVDNSRAKKKDYIKLEDINEIKEKGEFVKAITPTVMRVGICKVDNKEKSIYVNGVTSDYKYIENAEIIQGRYFTEKECVEGKAVVVIDEFTAKSLFGCKEVVGENILIGTSNNLKKLIIIGVTKSPGYMDAAPVEHIPAIATVPKNSLDNIFGKSEIESIFLLAKSKEDIEAASNEAINIISARHNNREKELYIGEKIIKQVEEINKVIDIFSSFISAVAGISLLVGGIGVMNIMLVSVTERTKEIGIRKAVGATTKSILLQFLTEAMIVSLIGGIIGLIVGITSAFLVGSIMGVIPKVTFLHIFLVIIFSSAVGIFFGIYPAKKAAQLDPIDALREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH36</accession>
    <name>A0A386PH36_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10000</name>
        <name evidence="3" type="ORF">EI377_04785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00329"/>
    <dbReference type="EnsemblBacteria" id="AYE34707">
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    </dbReference>
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        <property type="protein sequence ID" value="QAS60108"/>
        <property type="gene ID" value="EI377_04785"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="375" mass="43454" checksum="990E57DD243CF73D" modified="2018-12-05" version="1">MKSKNKYIVGAITIVFIILILYSLQPISNEAIKGNIVVWANDYTYDYLFKVAKEFEENNKRTKIKVINISNDEYLNSIKNVEKEKLPNIANLNFIDIQNLHEKVEIISETNEIIETYRNNFNKNRVKQIEYNEKYMGVPLTSRPIAFFIRKDILNEYGYKVEDINTWENLFKIGIDIFNKTNGDIRIFSSKDIDNIKLLMSAEAIQESKSDIKAKLIVESNIKNIFNTELISYYGDNNYMARIGSIEIINELNNELLGGKWICKLPPSINIGANKFYDLDGENLVVLNSDESNIRLIKNFMIYAATNVDLLQKQLVESRMFPSSLYTYKDKSIENAVKNTNENKSSPFIIFSNISERAPVLKNYKLLKDIIENSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH39</accession>
    <name>A0A386PH39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YjiH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08005</name>
        <name evidence="4" type="ORF">EI377_02765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675930.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34371">
        <property type="protein sequence ID" value="AYE34371"/>
        <property type="gene ID" value="CP523_08005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59777">
        <property type="protein sequence ID" value="QAS59777"/>
        <property type="gene ID" value="EI377_02765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="139"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="453" mass="49767" checksum="67F30B399298E444" modified="2018-12-05" version="1">MQKSISIKPSFKSILTFIIPSLIGIILFMTPVKHNGEITISVAILSKILVNFLGSSLPFIITITVCFSAIISIFTKIAKPNWILNNEYLNTLFNIGPLWFISRILGAVFCVLVIFNVGPLPIIGDSTGTFVLNDLLTILFSIFLFAGFFLPLLLDFGLLEFFGAILTKIMRPIFRLPGRSSIDCITSWLGDGTLGIILTSKQYEEGFYSKREATIISTTFSAVSITFSLVVISQVGLSHLFIPFYLTVTLAGIVAAVIIPRIYPLCKIPDTYYNNKPQVDNETIPEGYTSLTWGYNLALEKASKNNDLKDFFINGIKNVLDMWLGVLPVVMALATIALIIAEFTPIFQILGMPFIPILKILQVPEAVAASQTLVVGFADMLLPSVLAAKTITSDMTKFIIACTSVSQLIYMSEVGGVLLGSKIPVSLKQLLIIFLERTLITLPIIVLVANIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH61</accession>
    <name>A0A386PH61_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls</name>
        <name evidence="14" type="ORF">CP523_07045</name>
        <name evidence="15" type="ORF">EI377_01790</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673686.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01025"/>
    <dbReference type="EnsemblBacteria" id="AYE34228">
        <property type="protein sequence ID" value="AYE34228"/>
        <property type="gene ID" value="CP523_07045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59633">
        <property type="protein sequence ID" value="QAS59633"/>
        <property type="gene ID" value="EI377_01790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="511" mass="59552" checksum="FBE3EDDAA7AFFFE1" modified="2018-12-05" version="1">MRKVLKLLFSRMVIVGLLILIQLGILAFAIWKLSESFIYLYTLFIILSLIVVIYIVSRKDNPSYKLAWTIPVLLFPVFGGLFYLIFGGNKTSKEFKEKMAKVHNKTAKFLPQDVEILNEIQKEDKSIVNQVKYIKDYSMYPIYKNTTTEYLSPGEVFFEKLKEELKKAEHYIFMEYFIIQEGLMWDSILEILSEKARQGVDVRVIYDDMGCLQTLPYKYNEKLESLGIKCFVFNPFVPFVSLIMNNRDHRKITVIDGHTAFTGGINLADEYINEIVRFGHWKDASIMIKGEAVWNLTMMFLQVWDFNTNIQEDYELFKPDKHFEGIFESDGYVQPYGDSPLDSETVGENVYLNIINKAKDYVYINTPYLIVDNELVTALTLAAKGGVDIRIVTPHIEDKWYAHIVTRAYYAQLIEAGVKVYEYTPGFIHSKTFVSDDEIGVIGTINMDYRSLYLHFECGVWLYKTKSVFEIKEDFLNTLKVCQRITLEDCNKVKWSNRFIRSILRVFAPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH64</accession>
    <name>A0A386PH64_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677982.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33946">
        <property type="protein sequence ID" value="AYE33946"/>
        <property type="gene ID" value="CP523_05385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="211" mass="24453" checksum="EFCDF264AF4F9E2B" modified="2018-12-05" version="1">MIKEYLKIYKSNSYGILTIRNFFCTVLIGILFYIQIRNNLITNDIILISFSILIIMFACDSINNKLFINANNLKFEKKTFYTKIISSNIVCTLNISSYVLIWLFINIYLFDYTYNLNLTIKLLTLIIFSLALGNLLLATNHNKITLNISNKTKDKLIESIIPMLKTTFLSITLAIVLYYLLYNCTFVILFPLSILIYILSLLINIKISSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH72</accession>
    <name>A0A386PH72_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide chain release factor 3</fullName>
            <shortName evidence="6">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prfC</name>
        <name evidence="8" type="ORF">CP523_05190</name>
        <name evidence="9" type="ORF">EI377_15750</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE33912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01827"/>
    <dbReference type="EnsemblBacteria" id="AYE33912">
        <property type="protein sequence ID" value="AYE33912"/>
        <property type="gene ID" value="CP523_05190"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62063"/>
        <property type="gene ID" value="EI377_15750"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:translation release factor activity, codon specific"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
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    <feature type="binding site" evidence="6">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="531" mass="60262" checksum="BCD0BBFCB9970C8A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA7</accession>
    <name>A0A386PHA7_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">DUF4184 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF4184 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12525</name>
        <name evidence="3" type="ORF">EI377_07415</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35180">
        <property type="protein sequence ID" value="AYE35180"/>
        <property type="gene ID" value="CP523_12525"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60583"/>
        <property type="gene ID" value="EI377_07415"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13803">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
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            <end position="120"/>
        </location>
    </feature>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="247" mass="28634" checksum="F7A6C3321B34FD4A" modified="2018-12-05" version="1">MPFTLSHPAAVIFFKNKYFNLMGLILGSMAPDFIYFLLFSPSSGIGHTLSGFIILNLPLCLILNYLFFTYIQEIFILTLPNFISKNYIYLLNKKNKLTTLKEYLVFIYSCIIGMITHIFWDAFTHNTGFFVENIDFLKNEVLLLNYNIPVYKILQHSSTLIGLLIVILFFFKIKNKGSITTNKINKKKFIFYIFIVQALTLIISYFFSIHIEGNFPLGRFVVTVVNGLFLGYLFSGIIYNKLNTTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB1</accession>
    <name>A0A386PHB1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05635</name>
        <name evidence="2" type="ORF">EI377_00065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33986">
        <property type="protein sequence ID" value="AYE33986"/>
        <property type="gene ID" value="CP523_05635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59349">
        <property type="protein sequence ID" value="QAS59349"/>
        <property type="gene ID" value="EI377_00065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="236" mass="27823" checksum="C4A2F8BB1F5D4AFC" modified="2018-12-05" version="1">MKQINFEKISLINDINKYNNEYFKCIDEKNSTSSLNFKSLIFKVMYYEHNFEIRMFIQENDNDINIEVLFENICKNVDVEDSIMDSIILEISKCAKVVENKLKTYDDIKDKLNNFNGKINLDSMFIYKNKHNLITELDSFQDEIKQLYLTLKPNNMEYNNYINELFVFGENGIKTALVLKELGIADFRKTRSGYLINFLDDTSNYSNSFIYNFSKEISNIGIPSMAIPIEILERSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF6</accession>
    <name>A0A386PHF6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">minE</name>
        <name evidence="4" type="ORF">CP523_10610</name>
        <name evidence="5" type="ORF">EI377_05395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674164.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01379"/>
    <dbReference type="EnsemblBacteria" id="AYE34817">
        <property type="protein sequence ID" value="AYE34817"/>
        <property type="gene ID" value="CP523_10610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60211">
        <property type="protein sequence ID" value="QAS60211"/>
        <property type="gene ID" value="EI377_05395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="88" mass="9944" checksum="10D9FD65C331CB21" modified="2018-12-05" version="1">MEFFKKFSSKPTPKEVAKDRLKLILIHDRGDLSQETLEQIRTEILAVLSKYIEIEAEDVEIAVSKPEAIEGNNPALIANIPIKNIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG6</accession>
    <name>A0A386PHG6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTPase Obg</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">obgE</name>
        <name evidence="7" type="synonym">obg</name>
        <name evidence="11" type="ORF">CP523_10665</name>
        <name evidence="12" type="ORF">EI377_05450</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674146.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01369"/>
    <dbReference type="EnsemblBacteria" id="AYE34827">
        <property type="protein sequence ID" value="AYE34827"/>
        <property type="gene ID" value="CP523_10665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60222">
        <property type="protein sequence ID" value="QAS60222"/>
        <property type="gene ID" value="EI377_05450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="159"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="345"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="429" mass="47574" checksum="A6CCFA3E79FC4E60" modified="2018-12-05" version="1">MFIDKAKVFVKSGDGGNGCVSFRREKYVPLGGPDGGDGGKGGSVIFKVDTGLTTLLDFKYKKKFIAQAGGKGEGSKCYGKDGEDLYINVPMGTIIRDFETNKVIADLSHKDDVFVLARGGKGGKGNCKFCTPTRQAPHFAEPGMPGEERWITLELKLLADVGLVGFPNVGKSTLLSTVTAAKPKIANYHFTTLKPNLGVVKVEGINAFVMADIPGIIEGASEGIGLGLEFLRHIERTRLLIHVVDISGIEGRDAIEDFIKINEELKKYSVKLWDRPQIVVANKADMLFDEEVFENFKKKVNELGFDKVFKMSAATKAGVEDVIKEAGRMLSEIPIIDLEIPEEERFIPEEKKFTYEISIEDGEDDNKVYVVTGSFVDRLLNSVNIHDADSLRYFHKVLRNKGVLDEIREMGIKDGDMVRLNDFEFEYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH9</accession>
    <name>A0A386PHH9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mini-ribonuclease 3</fullName>
            <shortName evidence="2">Mini-3</shortName>
            <shortName evidence="2">Mini-RNase 3</shortName>
            <ecNumber evidence="2">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mini-RNase III</fullName>
            <shortName evidence="2">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrnC</name>
        <name evidence="4" type="ORF">CP523_08865</name>
        <name evidence="5" type="ORF">EI377_03620</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MrnC RNase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678115.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02713"/>
    <dbReference type="EnsemblBacteria" id="AYE34521">
        <property type="protein sequence ID" value="AYE34521"/>
        <property type="gene ID" value="CP523_08865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59923">
        <property type="protein sequence ID" value="QAS59923"/>
        <property type="gene ID" value="EI377_03620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005520">
        <property type="entry name" value="UCP005520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="15741" checksum="7D170DAD63B589D2" modified="2018-12-05" version="1">MLDDLRIREFTKDEARQLNPLQLALIGDGVYEVYIRNYILAKNTGLSAHKMHVKAIGYVKAKSQSMIMHNIEDTLTEEELYIYKRGRNAKSATVPKNADVRDYRNATGFEALVGYLYLIGDKDKLTKILESSVTIELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK1</accession>
    <name>A0A386PHK1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">CP523_08975</name>
        <name evidence="9" type="ORF">EI377_03720</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678351.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00235"/>
    <dbReference type="EnsemblBacteria" id="AYE34541">
        <property type="protein sequence ID" value="AYE34541"/>
        <property type="gene ID" value="CP523_08975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59941">
        <property type="protein sequence ID" value="QAS59941"/>
        <property type="gene ID" value="EI377_03720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="209" mass="22587" checksum="1BA030232F41D833" modified="2018-12-05" version="1">MKKAILGKKIGMTQIFDENGKVIPVTVVEAGPCVVVQKKTIEKDGYEAIQVGFGDVREKLVNKPKKGHFAKAGVSLKRRLKEFRLEDCSTYEVGQEFKADIFAAGEKIDVSGVSKGKGFQGVIKRWNANRGPMTHGSKFHRAVGSMGASSDPSRTFKNKNMPGHMGAVNTTVINLEVVKVIAEKNLILIKGGIPGPNKGTVVIRNAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK4</accession>
    <name>A0A386PHK4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675155.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01936"/>
    <dbReference type="EnsemblBacteria" id="AYE34086">
        <property type="protein sequence ID" value="AYE34086"/>
        <property type="gene ID" value="CP523_06175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="dCache_2" evidence="2">
        <location>
            <begin position="166"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="3">
        <location>
            <begin position="446"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="561" mass="65388" checksum="645468778570C384" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN7</accession>
    <name>A0A386PHN7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cro/Cl family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Sugar-binding transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03990</name>
        <name evidence="4" type="ORF">EI377_14510</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679261.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01945"/>
    <dbReference type="EnsemblBacteria" id="AYE33689">
        <property type="protein sequence ID" value="AYE33689"/>
        <property type="gene ID" value="CP523_03990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61844">
        <property type="protein sequence ID" value="QAS61844"/>
        <property type="gene ID" value="EI377_14510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="90"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="346" mass="38380" checksum="7B27EB842AEFE7FA" modified="2018-12-05" version="1">MQEILSLQKKIVPELVEVLEKRYNVLRTIYYNQPIGRRVLANQLDLGERIVRTEISFLKSQNLIEINTPGMTVTKEGQEVVDKLKDFMHEIKGLSDIEGNVKSFLGLREVIIVPGDVEANPMVFKELGKAAANYLKSIIKDDNIIAITGGNTIREFVDAFPKVNNVNNILVVPARGGMGRKVEIQASTLAASLAKKLNGNYKMLHIPENLSLELLDTLLKEKEIKEVIDQIHKADILIYGIGNALVMAEKRGVSLKEFNKLKELDAVGEAFGCYFNEKSEVVSENTTIGIKINDAKKINTHIAVAAGKNKVESILATMMNNSNAVLVTDEAAGRKIVDFIKESHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS7</accession>
    <name>A0A386PHS7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06425</name>
        <name evidence="8" type="ORF">EI377_00900</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677421.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02161"/>
    <dbReference type="EnsemblBacteria" id="AYE34132">
        <property type="protein sequence ID" value="AYE34132"/>
        <property type="gene ID" value="CP523_06425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59499">
        <property type="protein sequence ID" value="QAS59499"/>
        <property type="gene ID" value="EI377_00900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="407" mass="45250" checksum="5BC337F35DF648F8" modified="2018-12-05" version="1">MKSTLKLEKRVLKLIYLLCLLLFTNLALLKKPFDYKALGMGVILCLIIGYSHYVIRKFYPDGDKFMLIFSSILAVVGIAVIYRINPSEAMKQLIWVVLGIISYIAIVVILPDLKSFAKYKRIYMILTLVLMPMALILGKEIYGAKNWVYVAGFGFQPSEFGKIALVLYLAAALMKYESKKNLKEEFKQLIEPALIAMYSLACMVLQTDLGSALIFFGISVTMLYIATSKKKYVFTCLGLSAIGAVGAYKMFGHVRNRVMIWLDPWKYANDQGMQIVQGLYAISSGGLFGVGLGKGYPEFIPVNTSDFIFAVVCEELGMIFAVGIMIIYFLLFYRGIRAAFVTNEKFSQLSAVGFSTMIACQTLVIIGGIFKVIPLTGITLPLISYGGSSMITIFFTLGILQKISEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX3</accession>
    <name>A0A386PHX3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore cortex biosynthesis protein YabQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yabQ</name>
        <name evidence="2" type="ORF">CP523_08565</name>
        <name evidence="3" type="ORF">EI377_03315</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674883.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01654"/>
    <dbReference type="EnsemblBacteria" id="AYE34478">
        <property type="protein sequence ID" value="AYE34478"/>
        <property type="gene ID" value="CP523_08565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59880">
        <property type="protein sequence ID" value="QAS59880"/>
        <property type="gene ID" value="EI377_03315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014242">
        <property type="entry name" value="Spore_cortex_biosyn_YabQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019074">
        <property type="entry name" value="YabQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09578">
        <property type="entry name" value="Spore_YabQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02893">
        <property type="entry name" value="spore_yabQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="129" mass="14953" checksum="44777635B456A03C" modified="2018-12-05" version="1">MPLPINIQFHIVIYAILAGLLTGIIFDLYKIIRGVKIPKIIIVIEDILFWGLTALIVFTFLLYTNYAFLGPYVYAFMLVTILIYLRFISNKIFKLEKNILRVCSKGVRIIFKNIIYPIKLMYSSISGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX5</accession>
    <name>A0A386PHX5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4230 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06925</name>
        <name evidence="2" type="ORF">EI377_01410</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673641.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34206">
        <property type="protein sequence ID" value="AYE34206"/>
        <property type="gene ID" value="CP523_06925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59571">
        <property type="protein sequence ID" value="QAS59571"/>
        <property type="gene ID" value="EI377_01410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025324">
        <property type="entry name" value="DUF4230"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14014">
        <property type="entry name" value="DUF4230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="19313" checksum="C37A249B1EB3A800" modified="2018-12-05" version="1">MSEESLIKEIRDVNKIIPLEIELSETIVVDKSWGDFEVFKKIKRIKFFANCSYTVDLSSIGDKDININKQTKEVELYLPKPQIFSIDIDENKTIYEEASNGLLRFGDIQLTSEEHGVIQRETSKIFESKMKDSQIYDKAISNTNVVLEKLLRQISGNDMKVKVNFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY8</accession>
    <name>A0A386PHY8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_06905</name>
        <name evidence="16" type="ORF">EI377_01390</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00994"/>
    <dbReference type="EnsemblBacteria" id="AYE34202">
        <property type="protein sequence ID" value="AYE34202"/>
        <property type="gene ID" value="CP523_06905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59567">
        <property type="protein sequence ID" value="QAS59567"/>
        <property type="gene ID" value="EI377_01390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019866">
        <property type="term" value="C:organelle inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015572">
        <property type="term" value="F:N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010974">
        <property type="entry name" value="PTS_IIBC_nag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01998">
        <property type="entry name" value="PTS-II-BC-nag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="6"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="403"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS59567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="479" mass="50865" checksum="D43123270D1867E7" modified="2018-12-05" version="1">MSKGNTSVLGFLQKLGKALMTPIAALPAAGLLLRLGQPDVLDISWMAAAGDAIMGNMAILFAIGIAVGLAEENNGVAGLAGAIGYFVLTKVAFAFAGELNPGIADGSIKFDMGVLAGFATGIIGGLLYNKFKDIKVPQFLGFFGGKRFVPIITSLVCLILGVAMGWIWPSIQDGINNFGNTMANSGPIGAFGFGFLNRLLIPIGLHHVLNTIFWFQFGTFTAASGEVFNGDIFRFLNGDPTAGAFQTGFFPIMMFALPAACFAMIAAAKKEKRKAVTGMLAGIAFTSFLTGVTEPIEFTFMFLAPVLYGAHALLTGVSLALTNFLGMRDGFSFSAGFIDYVLNFNIAENPIGLVFVGLAFAAIYFVIFYAVIKKFDLKTPGREDDEIDVIDSRDMKGKKSDLDVTAKGIIEAIGGKDNIKSLDACVTRIRLTLADSKKIDESKLKKLGATGVMKLSGNNVQVVVGTIADPLVSRMKKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI41</accession>
    <name>A0A386PI41_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10700</name>
        <name evidence="4" type="ORF">EI377_05485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674133.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01362"/>
    <dbReference type="EnsemblBacteria" id="AYE34834">
        <property type="protein sequence ID" value="AYE34834"/>
        <property type="gene ID" value="CP523_10700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60229">
        <property type="protein sequence ID" value="QAS60229"/>
        <property type="gene ID" value="EI377_05485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="235" mass="26572" checksum="35612C7C5D0CA2D6" modified="2018-12-05" version="1">MKKINIKYLKSFNLYNYKKFIGILILLIISITFIFLKYDDNKNKVFKDEYMKEIFVEENIDELEKEDIPSNSEVVSNNIKENNSTDVVVEIKGEVKKPDVYTLKDGSIIKDLIDIAGGITENGDISMINRADILKNHQLIIVPNINDKKEQGDGVKVIGAELQSNLNSSNTHSKVNINTADINELKTIKGIGDSKAENIIKYREVNGAFKSIDEIKQVTGIGDKIFENMKDQITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI48</accession>
    <name>A0A386PI48_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673765.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34272">
        <property type="protein sequence ID" value="AYE34272"/>
        <property type="gene ID" value="CP523_07315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="62" mass="7261" checksum="F0819BACD93644C3" modified="2018-12-05" version="1">MSREKTKLDINMDLKEKINSLDPNIAFLANEVLADIEKGKTENQIKEFIRDEITEIVKEEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI76</accession>
    <name>A0A386PI76_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tsaB</name>
        <name evidence="2" type="ORF">CP523_10405</name>
        <name evidence="3" type="ORF">EI377_05175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01419"/>
    <dbReference type="EnsemblBacteria" id="AYE34781">
        <property type="protein sequence ID" value="AYE34781"/>
        <property type="gene ID" value="CP523_10405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60176">
        <property type="protein sequence ID" value="QAS60176"/>
        <property type="gene ID" value="EI377_05175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="238" mass="26245" checksum="F2FF47AC3F3A07D4" modified="2018-12-05" version="1">MIVLSIDSSSQVATVALMKDDCLIGEYTLNHKREHSVLIMDMVEMLLKDNNLDINDIDGFVVSKGPGSFTGLRIGMATVKGLSFGSNKPYVSISSLDALAYSLINFDGIICPIMDALRNSVYTCLYKNENGNLTAITDYDALDLPYLVKLIKEKGDKVIFTGDGINKHKDYLKEHLPNAVFAPNHLSIVRASSLGELGIKMLIEGKYDSVNSSPLYLKKPQAERELEKRLALKNGNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI88</accession>
    <name>A0A386PI88_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional 2-keto-4-hydroxyglutarate aldolase/2-keto-3-deoxy-6-phosphogluconate aldolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
            <ecNumber evidence="3">4.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eda</name>
        <name evidence="2" type="ORF">CP523_03910</name>
        <name evidence="3" type="ORF">EI377_14435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01552"/>
    <dbReference type="EnsemblBacteria" id="AYE35813">
        <property type="protein sequence ID" value="AYE35813"/>
        <property type="gene ID" value="CP523_03910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62231">
        <property type="protein sequence ID" value="QAS62231"/>
        <property type="gene ID" value="EI377_14435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008700">
        <property type="term" value="F:4-hydroxy-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="209" mass="22731" checksum="30798D50A68552CF" modified="2018-12-05" version="1">MNKVKVLKGLEEEAFVLVLRTNTCEEGIDVAKAAIEGGCNIIEVTFTIPNASTVITELCKDKKEGVVIGAGTVLDSETARIAILAGAEFIVSPSFNKETATLCNRYGVPYIPGCFTVREIVEAREMGADVIKLFPGSAFKPSIVKDFKAPIKGLSIMVSGGVSFDNMEEWFKYGCDVVSIGSAIVNLKDPKVVKEETRKYIDRVKEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI92</accession>
    <name>A0A386PI92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na/Pi cotransporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sodium-dependent phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09160</name>
        <name evidence="10" type="ORF">EI377_03905</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678406.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00270"/>
    <dbReference type="EnsemblBacteria" id="AYE34578">
        <property type="protein sequence ID" value="AYE34578"/>
        <property type="gene ID" value="CP523_09160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59978">
        <property type="protein sequence ID" value="QAS59978"/>
        <property type="gene ID" value="EI377_03905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
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        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
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        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="345"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="450"/>
            <end position="534"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="538" mass="57805" checksum="4053F371658B0F48" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB4</accession>
    <name>A0A386PIB4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B12-binding domain-containing radical SAM protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TIGR03960 family B12-binding radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10635</name>
        <name evidence="4" type="ORF">EI377_05420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01375"/>
    <dbReference type="EnsemblBacteria" id="AYE34821">
        <property type="protein sequence ID" value="AYE34821"/>
        <property type="gene ID" value="CP523_10635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60216">
        <property type="protein sequence ID" value="QAS60216"/>
        <property type="gene ID" value="EI377_05420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10635"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
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    </dbReference>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="252"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="617" mass="71012" checksum="61A7B8E02066D875" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIE9</accession>
    <name>A0A386PIE9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35580">
        <property type="protein sequence ID" value="AYE35580"/>
        <property type="gene ID" value="CP523_14705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="152"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="337" mass="38444" checksum="0C24CF98D208083E" modified="2018-12-05" version="1">MSKTNIKCPRCNSDKLYKFGMNKQAKQKYQCKQCKRQFVLVDGDGRTKLNNPKCGKGTYLHHAYKHYNRYKCNNKKCNHIIVKHHTTNIDTASSELVSGSLSMKGMRFPLHVILTALTLYFLNNSSTRAISQFLMINAGIKVSHVTIASWTNKFAPFFKQKADKFKASLNLQSDDWHANETVVFINGERYYLWLAIDSETRFILAFHLTKSRSSDSAYTLVNEAKKIGEPANFITDRLPSYNEAVATLLPNTTHIPVAPMSSDTNNNLIESFNKTFKTWYKTKKGFNSFQKANNLIYLFIFHYNFIRPHGSLNNCTPAEVAGFASDSFAKNSWFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ9</accession>
    <name>A0A386PIJ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIIIAE</name>
        <name evidence="3" type="ORF">CP523_15030</name>
        <name evidence="4" type="ORF">EI377_09985</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676030.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01278"/>
    <dbReference type="EnsemblBacteria" id="AYE35640">
        <property type="protein sequence ID" value="AYE35640"/>
        <property type="gene ID" value="CP523_15030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61027">
        <property type="protein sequence ID" value="QAS61027"/>
        <property type="gene ID" value="EI377_09985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014194">
        <property type="entry name" value="Spore_III_AE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09546">
        <property type="entry name" value="Spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02829">
        <property type="entry name" value="spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788412" evidence="2">
        <location>
            <begin position="33"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="414" mass="45247" checksum="233D32A8B7985619" modified="2018-12-05" version="1">MEKIKKLTGKIIIIILLGLFLSSVPSFKTVYAQSEANLNEDTINKQYDENSQGEELLKDKEVEEKLSGLYSYINNMKSDVELINELDPVEYIKNYIKSGDGNLSLKKIAQAVTSFLFKEVKVVLSLTLSIIVISIICSLLKNLQRSFSNENISNIAFFACYALLIVILSKSFLISIELAKDVIIKISDFMAALLPILVMMLGTAGGFTQAVTMDPIILGATFIIPRIYLNIIIPLILMTFVLQFANNISTEYKIDNLCKLMKQTIIVLQGFILTVFIALLTIRGITSSTIDAVTLKTAKFAVDNFIPIVGKAFSDAIATVAGYSLIIKNAVSSIGLIIIVLLMIYPIIKLALISLVYKLTAALVEPIGEKRITDSIAAAGDALILIMSTVISVSIMFFILIAIMASAGKFVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR8</accession>
    <name>A0A386PIR8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15525</name>
        <name evidence="3" type="ORF">EI377_10235</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678705.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35730">
        <property type="protein sequence ID" value="AYE35730"/>
        <property type="gene ID" value="CP523_15525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61069">
        <property type="protein sequence ID" value="QAS61069"/>
        <property type="gene ID" value="EI377_10235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="25059" checksum="7DB0D334975DC144" modified="2018-12-05" version="1">MKKSTLLAIGILVSIIFIITIFTNKIDVYDKKIKHTKEIDAIQDFICYSNVLEEVKNNKRNYYKLVKTNEFYESISRRYRLYLGDNKHQSNLLGRNPFPAFIEYKIESPTDNEINYIKKIHDNSYSTIENYPIPKSIEYFKVTGKYINWDNLKRNDINENGTVKEEFLRKENLNEESIYNGSCIIVIVDEGEGYVVDYYEILNEFYGEVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIV2</accession>
    <name>A0A386PIV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11905</name>
        <name evidence="4" type="ORF">EI377_06725</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673447.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02939"/>
    <dbReference type="EnsemblBacteria" id="AYE35061">
        <property type="protein sequence ID" value="AYE35061"/>
        <property type="gene ID" value="CP523_11905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60454">
        <property type="protein sequence ID" value="QAS60454"/>
        <property type="gene ID" value="EI377_06725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="135" mass="15467" checksum="36F996373B91CE55" modified="2018-12-05" version="1">MDNITSIFREKKLKLTPQRLAVYKYLMSTKEHPSAETIYKALQPEYPTMSLATVYKALKTLVEVELVQEINVGEGNFRYDGNPCEHAHIQCINCSKVDDLENVSFNDLNKTAEDASDYKVISNKVFFYGICKECQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW7</accession>
    <name>A0A386PIW7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobB</name>
        <name evidence="6" type="ORF">CP523_09385</name>
        <name evidence="7" type="ORF">EI377_04130</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class U subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678033.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02735"/>
    <dbReference type="EnsemblBacteria" id="AYE34622">
        <property type="protein sequence ID" value="AYE34622"/>
        <property type="gene ID" value="CP523_09385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60022">
        <property type="protein sequence ID" value="QAS60022"/>
        <property type="gene ID" value="EI377_04130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09385"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01968">
        <property type="entry name" value="Sirtuin_ClassU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028628">
        <property type="entry name" value="Sirtuin_class_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="245" mass="26981" checksum="6398C4036482CC29" modified="2018-12-05" version="1">MNNKIEELSRILKESNNIVFFGGAGCSCESGIPDFRSSNGLFNEKLNTKFTPEQLVSHSFYIRYPKEFFNFYKSKLIYPTAKPNGTHFTLAKLEEMGKLKAVITQNIDGLHQMAGSKNVFELHGSVHRNYCTQCHAFYDSNFVLESKEIPTCTKCGGTVKPDVVLYEEGLDDDVITASIDAISKADTLIIGGTSLVVYPAAGLINYFRGKNLILINKSSTSADSKANLVINDSIGKVLTTAINNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ31</accession>
    <name>A0A386PJ31_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopentomutase</fullName>
            <ecNumber evidence="4">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">deoB</name>
        <name evidence="6" type="ORF">CP523_15150</name>
        <name evidence="7" type="ORF">EI377_10105</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphopentomutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679015.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00098"/>
    <dbReference type="EnsemblBacteria" id="AYE35890">
        <property type="protein sequence ID" value="AYE35890"/>
        <property type="gene ID" value="CP523_15150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61048">
        <property type="protein sequence ID" value="QAS61048"/>
        <property type="gene ID" value="EI377_10105"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15150"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="2"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="388" mass="42801" checksum="E2B4A01B00C58486" modified="2018-12-05" version="1">MKRAILVVMDSLGVGALPDADLYGDAGSHTLDHVYKACGGLNIPNLENLGFGNIEGVTELKKVDKTTGAYGRLMERSKGKDTVTGHWEIGGVILEKPLNTYPNGFSDEIINEFLAKVNKKGILGNCVASGTAIIEELGDEHVKTGYPIIYTSADSVFQIAAHEDVIPLEELYKMCQIAREMLVGEHAVGRVIARPFVGKSGEYKRTPNRRDYALDPFSKTMLEYLKENGKEVAAVGKIEDIYNQKGVTDAIHTKNNMDGVDVTLKYMDTVKEGLIFTNLVDFDMLYGHRNDPKGYGKAIEDLDGRLNEIYSKMTDEDILILTADHGCDPTTSSTDHSREYIPVLIYGKNIKPVNLGTKTGFTDIGKTILDYFNIENDIDGSSFLKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ46</accession>
    <name>A0A386PJ46_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14140</name>
        <name evidence="4" type="ORF">EI377_09045</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03104"/>
    <dbReference type="EnsemblBacteria" id="AYE35477">
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        <property type="gene ID" value="CP523_14140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60864">
        <property type="protein sequence ID" value="QAS60864"/>
        <property type="gene ID" value="EI377_09045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362749" evidence="2">
        <location>
            <begin position="30"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="568" mass="62303" checksum="D8B6DA5A0DE474E6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ55</accession>
    <name>A0A386PJ55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter NhaC family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Sodium:proton antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09490</name>
        <name evidence="9" type="ORF">EI377_04235</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AYE34636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679257.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00753"/>
    <dbReference type="EnsemblBacteria" id="AYE34636">
        <property type="protein sequence ID" value="AYE34636"/>
        <property type="gene ID" value="CP523_09490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60035">
        <property type="protein sequence ID" value="QAS60035"/>
        <property type="gene ID" value="EI377_04235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="229"/>
            <end position="419"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="425" mass="44888" checksum="3BFE601EBE80737D" modified="2018-12-05" version="1">MESKSSALALLPLGIFIVVYLGISLIAKDFYAVSVIVPFLAAALTAIIMNRKEKFETKVETFCKGAGNPNILLMVLIFILAGAFAQTARDMGAVDSTVNLGLSLLPSSLLIPGMFIIACFIALSVGTSMGTIVALVPIAVGIADRTGITAALAVGAVVSGSMFGDNLSIISDTTIAATRTQGCEMKDKFKMNFKIVLPAAIATALILWFLTKGANVTNVETVEYTFVKILPYIAVIASALAGVNVILVLLGGILISAIIGLAYGSFNLVGLFGSISNGISGMSELIIISLLIAGTIEIIKFNGGIEFILHKGLKNFKSKRGAEFGIATLVSLVDICTANNTVAIVTVGPIAKDISDEFDLEPKRVAGIMDMFSCVFQGIIPYGAQLISAAGLAVISPFGIMKYLFYPYLMGICAIIAIYWHWRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ76</accession>
    <name>A0A386PJ76_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13095</name>
        <name evidence="3" type="ORF">EI377_07965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02560"/>
    <dbReference type="EnsemblBacteria" id="AYE35284">
        <property type="protein sequence ID" value="AYE35284"/>
        <property type="gene ID" value="CP523_13095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60678">
        <property type="protein sequence ID" value="QAS60678"/>
        <property type="gene ID" value="EI377_07965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="10"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="26147" checksum="08B5E401F920414A" modified="2018-12-05" version="1">MIKILATGSKGNCYLIQAGDEKLLLECGITWNEILKGLDFNIKGILGCLISHEHKDHSKSYKKIIKNGIDVYTSKGTLAGIGNTPKGRRDKIIKASEKFKIGNFNILPFEIEHDAFEPLGFIIGHPKLGKILFATDTYYLKYKFKNIDHILIECNYSEKILHDLEPHRARVLKSHMSLETLVTALKTWDLSRTKDIILIHISDKNGDSEEFKKEIESITGIKTIIAAPGTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJD6</accession>
    <name>A0A386PJD6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07405</name>
        <name evidence="2" type="ORF">EI377_02095</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673782.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01090"/>
    <dbReference type="EnsemblBacteria" id="AYE34289">
        <property type="protein sequence ID" value="AYE34289"/>
        <property type="gene ID" value="CP523_07405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59683">
        <property type="protein sequence ID" value="QAS59683"/>
        <property type="gene ID" value="EI377_02095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014871">
        <property type="entry name" value="dUTPase/dCTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016947">
        <property type="entry name" value="UCP030140"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08761">
        <property type="entry name" value="dUTPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030140">
        <property type="entry name" value="UCP030140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="151" mass="17562" checksum="F97155E8CCC42408" modified="2018-12-05" version="1">MDAKSLFEAQLEKNQKININSKLNQYKLSVRKNLDLHIKIGSLADETKCYKYWIDEDSSINMNLIFEKYLDCLGQILTIGLDKNYSDITDIRVKPNDYCLSDQFLNLYIDINDLTISPSKDHFLTLLEDFISLGITLGYSEYKIKESFINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJF0</accession>
    <name>A0A386PJF0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaE</name>
        <name evidence="5" type="ORF">CP523_10410</name>
        <name evidence="6" type="ORF">EI377_05180</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674236.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01418"/>
    <dbReference type="EnsemblBacteria" id="AYE34782">
        <property type="protein sequence ID" value="AYE34782"/>
        <property type="gene ID" value="CP523_10410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60177">
        <property type="protein sequence ID" value="QAS60177"/>
        <property type="gene ID" value="EI377_05180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="153" mass="17357" checksum="303715580ED4F460" modified="2018-12-05" version="1">MHFNVDNVESTTAIGYALGKLLKSGDIVCLTGDLGTGKTHITKGIAKGLDINEHITSPTFTIVNEYDSGRLKLFHFDVYRVSDPDEIYAIGFDDYIFSDGVSIIEWANYIEDILPKDFIHILIEKDLDKGENFRKITITPYGDRYNYVKELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL4</accession>
    <name>A0A386PJL4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35687">
        <property type="protein sequence ID" value="AYE35687"/>
        <property type="gene ID" value="CP523_15305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046242">
        <property type="entry name" value="DUF6275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19791">
        <property type="entry name" value="DUF6275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="87" mass="10579" checksum="8B283C37706559CD" modified="2018-12-05" version="1">MNEKEFLEWCKQEVCNYTNKHLDKTDKKEITTDDVFMVWSCKTLQNNKALISTTLFDGMYYECTYNGDKKEMYVDAYKKWENYKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJV0</accession>
    <name>A0A386PJV0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="5">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xth</name>
        <name evidence="4" type="ORF">CP523_14315</name>
        <name evidence="5" type="ORF">EI377_09225</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676779.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02452"/>
    <dbReference type="EnsemblBacteria" id="AYE35511">
        <property type="protein sequence ID" value="AYE35511"/>
        <property type="gene ID" value="CP523_14315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60896">
        <property type="protein sequence ID" value="QAS60896"/>
        <property type="gene ID" value="EI377_09225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="250" mass="29278" checksum="C90F429D49149B9B" modified="2018-12-05" version="1">MKLISWNVNGIRACVTKGFLDFFNEVDADIFCIQESKLQEGQIDLDLKGYYQYWNYAKKKGYSGTAIFTKKRPLNVKYGLGIEEHDNEGRVITLEFEDFYMITVYTPNSQNELARLNYRMEWEDAFREYLKQLDLIKPVIVCGDLNVAHNEIDLKNPKNNRRNAGFTDEERSKLTELLNVGFIDSFRHFNPDVEGIYSWWSYRFNARKNNAGWRIDYFLVSNKLKDRLVGADIHTSVLGSDHCPVELQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK13</accession>
    <name>A0A386PK13_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ORF">CP523_14710</name>
        <name evidence="9" type="ORF">EI377_09670</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676148.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01343"/>
    <dbReference type="EnsemblBacteria" id="AYE35581">
        <property type="protein sequence ID" value="AYE35581"/>
        <property type="gene ID" value="CP523_14710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60966">
        <property type="protein sequence ID" value="QAS60966"/>
        <property type="gene ID" value="EI377_09670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14710"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="397" mass="43543" checksum="7054D17B5D462DD3" modified="2018-12-05" version="1">MKVLVINCGSSSLKYQLIDMATEEAMVQGLVERIGIEGSVLVQKVEGRDKYIINTEIKDHKAAIKLVLGAIIDKEHGVIKSMEEITAVGHRVVHGGEKYSESVIITDKVLESIRECIALAPLHNPPNIIGIEACMELMPNTPMVVVFDTAFHQTMPKEAYICPVPYELYEKYGIRKYGFHGTSHKYVANKAAEVMGKDIKDLKIITCHLGNGCSITAVKGGKSVDTSMGFTPLAGVMMGTRSGNIDPSVIGFLVKEQGYTMKEIDELLNKKSGILGVSGISSDFRDVREAYTEGNERAKLALDIFHYKIRSQIAAYAGIMGGVDAIVFTAGIGENSSLTRKESLKGLEFLGFTINEEKNEVRADVQEISDEGSKVKVYEIATNEELMIARDTKELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK81</accession>
    <name>A0A386PK81_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_12125</name>
        <name evidence="9" type="ORF">EI377_06955</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673532.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02982"/>
    <dbReference type="EnsemblBacteria" id="AYE35102">
        <property type="protein sequence ID" value="AYE35102"/>
        <property type="gene ID" value="CP523_12125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60495">
        <property type="protein sequence ID" value="QAS60495"/>
        <property type="gene ID" value="EI377_06955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="407"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="542"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="794" mass="92218" checksum="7C0B0051CA035AD9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK86</accession>
    <name>A0A386PK86_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35671">
        <property type="protein sequence ID" value="AYE35671"/>
        <property type="gene ID" value="CP523_15215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="140" mass="16293" checksum="D0CA5FD99D3E9E16" modified="2018-12-05" version="1">MISLFSRRFNMDIKERIKILRKDILKLTQTDFGNRIGVAKSTIAGYELGTRRPIDRAINSICREFNVSHAWLTEGIGDPFIQSDDDDIIELINKALSNENEFIRNVFKSFAKLDTKHWEALEEFMKISLGIDEKKQENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKH6</accession>
    <name>A0A386PKH6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="8">2.4.1.129</ecNumber>
            <ecNumber evidence="7">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CP523_13985</name>
        <name evidence="23" type="ORF">EI377_08890</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="23 25" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 25">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="8"/>
    <dbReference type="EC" id="3.4.16.4" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678632.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00214"/>
    <dbReference type="EnsemblBacteria" id="AYE35448">
        <property type="protein sequence ID" value="AYE35448"/>
        <property type="gene ID" value="CP523_13985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60836">
        <property type="protein sequence ID" value="QAS60836"/>
        <property type="gene ID" value="EI377_08890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13985"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="21">
        <location>
            <begin position="86"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="20">
        <location>
            <begin position="387"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="777"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="784"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AYE35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QAS60836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="868" mass="96780" checksum="AAAE4A941E060846" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKV8</accession>
    <name>A0A386PKV8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF386 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11230</name>
        <name evidence="2" type="ORF">EI377_06020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677036.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00894"/>
    <dbReference type="EnsemblBacteria" id="AYE34939">
        <property type="protein sequence ID" value="AYE34939"/>
        <property type="gene ID" value="CP523_11230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60333">
        <property type="protein sequence ID" value="QAS60333"/>
        <property type="gene ID" value="EI377_06020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="150" mass="17796" checksum="AF0AABB39CEECF95" modified="2018-12-05" version="1">MIYGSLKHMDRYNFLDRDIIDCFKYTIEKNLSNFEKGTYKIDGDNMFVNVVEYETQNKEDRFWEAHKKYIDIHLMIEGKEKIQVNSIENLEAKEYEEKNDFVSLEGLESGYVTLRKGDFLICYPEDAHMTAIKVDNTEKVKKAIFKVIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL72</accession>
    <name>A0A386PL72_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12165</name>
        <name evidence="3" type="ORF">EI377_06985</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35109">
        <property type="protein sequence ID" value="AYE35109"/>
        <property type="gene ID" value="CP523_12165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60500">
        <property type="protein sequence ID" value="QAS60500"/>
        <property type="gene ID" value="EI377_06985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="546" mass="63431" checksum="59069ED772EE8354" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL84</accession>
    <name>A0A386PL84_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbohydrate deacetylase</fullName>
            <ecNumber evidence="6">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_12265</name>
        <name evidence="8" type="ORF">EI377_07090</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the YdjC deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673597.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03008"/>
    <dbReference type="EnsemblBacteria" id="AYE35129">
        <property type="protein sequence ID" value="AYE35129"/>
        <property type="gene ID" value="CP523_12265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60521">
        <property type="protein sequence ID" value="QAS60521"/>
        <property type="gene ID" value="EI377_07090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10803">
        <property type="entry name" value="YdjC_EF3048_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01246">
        <property type="entry name" value="COD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022948">
        <property type="entry name" value="COD_ChbG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="245" mass="28012" checksum="98A4C66DB942A366" modified="2018-12-05" version="1">MKLIVNSDDFGISKSVTLGIIEAHKNGVVTSTTLMCNMENAKEAVELSREFKDLGVGIHLVLTAGYPLAKGVSSLIDESGKFLKIDKIREVAKIEDIRKEFKCQMEKFLSFGIKPTHIDTHHHVHSIPKVLEVVKELALEYNLPIRILENERESISREIKGVDKFVGSFYDNENITVENFIDILEKNKDVKVLEIMCHPGYLDDYILNNSSYSIQRTKELKTLTNNKIKEYINKNKIDLINYKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLA0</accession>
    <name>A0A386PLA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12420</name>
        <name evidence="4" type="ORF">EI377_07305</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675340.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02029"/>
    <dbReference type="EnsemblBacteria" id="AYE35159">
        <property type="protein sequence ID" value="AYE35159"/>
        <property type="gene ID" value="CP523_12420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60562">
        <property type="protein sequence ID" value="QAS60562"/>
        <property type="gene ID" value="EI377_07305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="102" mass="10838" checksum="408B6B4DCC5430CB" modified="2018-12-05" version="1">MARYEALGLIETFGLVFALEAADAMCKASNVELEGYANVASGYITVLVRGDVGACKAAVDAGVAAVEAMEGANLYSSMVIPRPHQDIEKIIKRYELVNLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLB4</accession>
    <name>A0A386PLB4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent helicase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_14450</name>
        <name evidence="12" type="ORF">EI377_09425</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676824.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02483"/>
    <dbReference type="EnsemblBacteria" id="AYE35536">
        <property type="protein sequence ID" value="AYE35536"/>
        <property type="gene ID" value="CP523_14450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60923">
        <property type="protein sequence ID" value="QAS60923"/>
        <property type="gene ID" value="EI377_09425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="33"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="233"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="380" mass="42779" checksum="8A43FB32DEB6B9AC" modified="2018-12-05" version="1">MNNFNELSLKPNIVEALKIQGITEPTEIQSKAIPELLKNKDLIGESHTGSGKTLAYLLPIFEKINSEKREMQSIILAPTHELVRQIEEEIKLLSKNSKSNITSLTVIGDVNIDRQIKKIKEVKPHIIVGSPGRVLDLIRKKKITAHTIKTIVIDEADNLLDKNNYKIILDIIKTTMRDRQLMVFSATISDNTMKISKELMKEPVVIKATGKPALNPKITHMYIEGDRRDKFEILRKLIAAINPNKSIVFVNNNTDIDIITQKLNYHGKPAFNISSHISKEARQKSLQDFRNGKINILVSSDLSARGLDVPDVTHIFNLDFPVNANDYLHRAGRTARGENSGVAISIATGKDLAGIRVYEREFNIKIHPMKVYNGKLMDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLC2</accession>
    <name>A0A386PLC2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">CP523_14515</name>
        <name evidence="13" type="ORF">EI377_09485</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00209"/>
    <dbReference type="EnsemblBacteria" id="AYE35546">
        <property type="protein sequence ID" value="AYE35546"/>
        <property type="gene ID" value="CP523_14515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60932">
        <property type="protein sequence ID" value="QAS60932"/>
        <property type="gene ID" value="EI377_09485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14515"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="114"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="250" mass="27685" checksum="BD5ED32C11A73C1C" modified="2018-12-05" version="1">MIEIILNGCCGKMGKVITECSKEFDNLKIIGGIDKYPSNAPYPIFKSVADVSLKYDVLLDFSRSDALRDLLEITKKTKKPLILCSTGYDEEDLKLINEKSKTLPIFRSANMSLGINLINCLLRKVTPLLYENYDIEIIEKHHNQKLDSPSGTAILLANTIKESIKEETSFINGRNGHKKREKNEVGIHAVRGGSIVGDHDVIFAGTGEVIEINHKAISREVFAIGALKACSYMGNISKPGLYNMDNLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLF2</accession>
    <name>A0A386PLF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_15380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678757.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03070"/>
    <dbReference type="EnsemblBacteria" id="AYE35702">
        <property type="protein sequence ID" value="AYE35702"/>
        <property type="gene ID" value="CP523_15380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006480">
        <property type="entry name" value="Phage_holin_4_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05105">
        <property type="entry name" value="Phage_holin_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01593">
        <property type="entry name" value="holin_tox_secr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="141" mass="15705" checksum="CDAB2DAB8437610F" modified="2018-12-05" version="1">MENLFKYFNLVVAALGTGFTWLFGTWDIALISLIAFMILDYVTGVLRAYVNKDVSSSVGLKGIARKAVIFIVLIVAVILDRLLNTGTWVFRTLICYFYIANEGISLLENCAGLGLPIPEKLKDALVQLKDGEKKDLKIEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLL1</accession>
    <name>A0A386PLL1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678559.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35676">
        <property type="protein sequence ID" value="AYE35676"/>
        <property type="gene ID" value="CP523_15245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017297581" evidence="1">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="104" mass="11829" checksum="0F915348263ABFA3" modified="2018-12-05" version="1">MKKFIFTIITIFFLSSSCSFKTVYASNLFKEGIYTISDFNPPISNKYTVQNSSSENSVIIQVFNNDLLLLQSIKLTPNSEKYNLIELLPDYKIIIVGNGEIFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLR6</accession>
    <name>A0A386PLR6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA adenine methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_13355</name>
        <name evidence="5" type="ORF">EI377_08245</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677597.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00766"/>
    <dbReference type="REBASE" id="297236">
        <property type="entry name" value="M.CseVAT12ORF8245P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35872">
        <property type="protein sequence ID" value="AYE35872"/>
        <property type="gene ID" value="CP523_13355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60724">
        <property type="protein sequence ID" value="QAS60724"/>
        <property type="gene ID" value="EI377_08245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="29661" checksum="A54FD0D31CE5D390" modified="2018-12-05" version="1">MLKPPICRVGGKSKLRKSIIEQIPEHTCYIEVFFGAGWVYFGKESSKVEVINDIDKELVNLFRTIKYHAPEVERLLEYEFSGRDIFEEYKNCTLEYMTEIHRAIKFLYVITQSFAGKGNNYGYSTTTKPGQQIFYKEILLELRDRLKNTYVENLSFEKIIDKYDRKHSFFFCDPPYIKTCGYGNKFGEEEHRILANKLKEIQGKFLLTINDHPLARELYKEFNIKEVKVNYSIARENSARGKYNELIITNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLW6</accession>
    <name>A0A386PLW6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4364 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF4364 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14465</name>
        <name evidence="2" type="ORF">EI377_09440</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676834.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02486"/>
    <dbReference type="EnsemblBacteria" id="AYE35539">
        <property type="protein sequence ID" value="AYE35539"/>
        <property type="gene ID" value="CP523_14465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60926">
        <property type="protein sequence ID" value="QAS60926"/>
        <property type="gene ID" value="EI377_09440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025374">
        <property type="entry name" value="DUF4364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14277">
        <property type="entry name" value="DUF4364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="177" mass="20538" checksum="68B0A2A48790080C" modified="2018-12-05" version="1">MYENSTELAENKLLVLYVIKSLKQPITNTQLTEIILENNFINYFTLQQYISELISSEFLKYVLVNDKNLIDITEKGINVLSFFTDRISPIKKKIIDDYLLTIIDSIKKELTIHSDYTLGKNDSFLVDLQALEDESLLMELKVSVPSKKQAVSLCNRWKENPSEIYTKIINTLFTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM39</accession>
    <name>A0A386PM39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_15205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678580.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35669">
        <property type="protein sequence ID" value="AYE35669"/>
        <property type="gene ID" value="CP523_15205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="569" mass="65718" checksum="266359881343297B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAK1</accession>
    <name>A0A386PAK1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00055</name>
        <name evidence="6" type="ORF">EI377_10535</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678956.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00302"/>
    <dbReference type="EnsemblBacteria" id="AYE32953">
        <property type="protein sequence ID" value="AYE32953"/>
        <property type="gene ID" value="CP523_00055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61125">
        <property type="protein sequence ID" value="QAS61125"/>
        <property type="gene ID" value="EI377_10535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="240" mass="27472" checksum="6BC0BAABD00120F1" modified="2018-12-05" version="1">MEERLQKYMANCGVASRRKCEELILQGKVKVNGIIVNELGTKVIENVDIVEYNNRIIKKEENKLYIMLNKPEGYITSLKDEKGRKTILDLVNVKERIFPIGRLDYDSSGLLLLTNDGDIYNKIIHPRVKIKKTYIVTCKGEFNKNELNKFKKGIDIGDYITAPADIRVISIENVKEGKVSIVEIAIHEGKNRQIRRMCAALNHPVISLKRIAVGNIKLGYLKKGEWRNITNEELSYINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB46</accession>
    <name>A0A386PB46_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_01060</name>
        <name evidence="13" type="ORF">EI377_11555</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674479.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02307"/>
    <dbReference type="EnsemblBacteria" id="AYE33143">
        <property type="protein sequence ID" value="AYE33143"/>
        <property type="gene ID" value="CP523_01060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61313">
        <property type="protein sequence ID" value="QAS61313"/>
        <property type="gene ID" value="EI377_11555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="11">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="26777" checksum="403E64381B79CFD0" modified="2018-12-05" version="1">MAHERVLVVDDESHIVELISYNLINAGYDVITANNGCDAIKIAKDEKPSLVLLDLMLPGMDGFDVCKEIKGNKELKNTSIIMLTAKGEELDKILGLELGADDYITKPFSIRELLARVKAVLRRVSPLKEEIETFTCENLYVNFERREVFIENKKIDLTLKEFELLDILIKNRGKILTRDTLLDKIWGYEYIGETRTVDVHIRYLRKKIELDDKKPKFIETIRGVGYRFNPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBJ7</accession>
    <name>A0A386PBJ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="12">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">rlmN</name>
        <name evidence="14" type="ORF">CP523_00940</name>
        <name evidence="15" type="ORF">EI377_11435</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674531.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02331"/>
    <dbReference type="EnsemblBacteria" id="AYE33120">
        <property type="protein sequence ID" value="AYE33120"/>
        <property type="gene ID" value="CP523_00940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61290">
        <property type="protein sequence ID" value="QAS61290"/>
        <property type="gene ID" value="EI377_11435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="96"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="343" mass="39088" checksum="2D9AC2A4F1973C9A" modified="2018-12-05" version="1">MKNILDYTLEELSIWMKENNENAFRAKQVISWLYKEVWDFSDMRNISKTLQDKLTSNFYIGIPKIVDMFESKIDDTKKLLLVFKDGNIIESVIMKYKHGYSICISTQVGCRMGCKFCASTLDGRVRDLTAGEILSQIMVAQKIIGERISNVVLMGSGEPLDNYENVLKFLELVNAEYGLNIGQRHITLSTCGLVPKIYDLADRKSSITLAISLHAFSDEKRREIMPIANKYSIKEILEACKYYIDKTGRRITFEYSLVSGVNDGLEDAKSLAKLLKGLLCHVNLIPVNEIKENTLKRPSKKTIINFEEILKNNGIEVTVRREMGSDINAACGQLRRKFLETQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBK9</accession>
    <name>A0A386PBK9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NCS2 family permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_00995</name>
        <name evidence="9" type="ORF">EI377_11490</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674513.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02320"/>
    <dbReference type="EnsemblBacteria" id="AYE33130">
        <property type="protein sequence ID" value="AYE33130"/>
        <property type="gene ID" value="CP523_00995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61300">
        <property type="protein sequence ID" value="QAS61300"/>
        <property type="gene ID" value="EI377_11490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="456" mass="48032" checksum="98764CBE9CE828F9" modified="2018-12-05" version="1">MENLSIKEQVLPILTNKNVNFKKEIVAGITTFLTMAYIIVVNPNILSETGMPAGPLVTATCLSAAFGCILMGLFANLPFALASGMGLNAFFAFSVVLGQGISWEMALTAVFVEGIIFILLSLFKVREAVVNAIPVNMKHSVTAGIGIFIAFIGLVGCGLVVNDDATLVAMGEFTPAVVIALVGVVVIAVLDKKQVRGSILFGILISTLLAWGFAFIKPEEAANLGMYLPSGVFKFESIAPIAGKLDFGFITSKETIGTFIAVVCTFLFVDFFDTVGTLVGVASRANMLDEEGKVPNVGKALLVDAVATTAGAAMGVSTVTTYVESSTGVAAGGKTGYTAIVTGILFLISMFFSPIFISIPACATAPALIYVGYLMLGAVKNINFDNITEGVPAFLTIITMALTYSIGDGLTVGILSYVIINVLYNVFFANKEEKVKISWVMISLAVIFILKIAFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBP7</accession>
    <name>A0A386PBP7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hut operon positive regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_01210</name>
        <name evidence="7" type="ORF">EI377_11710</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HutP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674374.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02276"/>
    <dbReference type="EnsemblBacteria" id="AYE33170">
        <property type="protein sequence ID" value="AYE33170"/>
        <property type="gene ID" value="CP523_01210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61340">
        <property type="protein sequence ID" value="QAS61340"/>
        <property type="gene ID" value="EI377_11710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006547">
        <property type="term" value="P:histidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015111">
        <property type="entry name" value="Regulatory_HutP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036482">
        <property type="entry name" value="Regulatory_HutP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09021">
        <property type="entry name" value="HutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="14784" checksum="4E93EC08016D5949" modified="2018-12-05" version="1">MGNNSLEVAKIATKMAISSREEEEILKIDFKKEGFLVTAVNIGGNINESTSKILERALVASKRNGVIREEHLHEGGIIGATRDALMQVWNRASGQNVGGKIGIARKGEHLSVCIFLSVGLLHLDEVVIGIGHRAISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBS2</accession>
    <name>A0A386PBS2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigF</name>
        <name evidence="9" type="ORF">CP523_02355</name>
        <name evidence="10" type="ORF">EI377_12875</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673988.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00496"/>
    <dbReference type="EnsemblBacteria" id="AYE33385">
        <property type="protein sequence ID" value="AYE33385"/>
        <property type="gene ID" value="CP523_02355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61556">
        <property type="protein sequence ID" value="QAS61556"/>
        <property type="gene ID" value="EI377_12875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014236">
        <property type="entry name" value="RNA_pol_sigma-F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02885">
        <property type="entry name" value="spore_sigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="29019" checksum="7B98BDAB08404D3C" modified="2018-12-05" version="1">MENGILRREEYNYDDNSQLIPLAKAGDKEAMDRVIEMNLPLVSSISKKFLNRGYDYEDIFQIGSIGLVKAIKNFDSKFNVKFSTYAVPMIIGEIKRFIRDDGMIKVSRNVKSLARKLHFDKEELTKKLDRDPTIEELSEFSGVDKEEILFAIESSNSLQYLYDTIHQDDGAPVLLIDKLSEKCEEDTDMIDKIALKEALRSLDNKARQIIMLRYFKDKTQVQVAKLLGISQVQVSRIEKKVLVQMRNRLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBT2</accession>
    <name>A0A386PBT2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00290</name>
        <name evidence="2" type="ORF">EI377_10595</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677358.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32997">
        <property type="protein sequence ID" value="AYE32997"/>
        <property type="gene ID" value="CP523_00290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61136">
        <property type="protein sequence ID" value="QAS61136"/>
        <property type="gene ID" value="EI377_10595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="24959" checksum="A1AA9CBF0D2842D6" modified="2018-12-05" version="1">MKKKSIILTTLLIILTFCFSIVAIYKHYFYPNIEVKSINSEAIIDNKKLLAKFFPNKLNLSLSEISLESKVNFTEEELTDLFISVVNEIPDLKNNVTGLKVNINNNKLYIFINFKYNNLPLQIKTIFMPYSENGEGIFHFQEGKIGFINIEKDTFFKYLEDTSIIQFDKKQGNVIISFVNTDILEITDISTNENNLDILFKAHLNLFKSKKDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC11</accession>
    <name>A0A386PC11_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF327 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF327 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01895</name>
        <name evidence="2" type="ORF">EI377_12400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678284.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01169"/>
    <dbReference type="EnsemblBacteria" id="AYE33300">
        <property type="protein sequence ID" value="AYE33300"/>
        <property type="gene ID" value="CP523_01895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61469">
        <property type="protein sequence ID" value="QAS61469"/>
        <property type="gene ID" value="EI377_12400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005585">
        <property type="entry name" value="DUF327"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024042">
        <property type="entry name" value="TM1646-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03885">
        <property type="entry name" value="DUF327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158397">
        <property type="entry name" value="SSF158397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="140" mass="16624" checksum="A502CAB3F3DAA2E2" modified="2018-12-05" version="1">MEIGRVNRKSLIKQDRKITSEKKDFSQSFNQARERKSEEQLKKMIEDIKKRGNKLVITKTYGDVVVYKKMIKEYLESILKFMYDTQKDISFWQTQYFITVDTIDLKLEELTQSLLSDEKENLNIAASIDEIQGLIVDIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCA5</accession>
    <name>A0A386PCA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677909.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02248"/>
    <dbReference type="EnsemblBacteria" id="AYE33593">
        <property type="protein sequence ID" value="AYE33593"/>
        <property type="gene ID" value="CP523_03485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="333" mass="38345" checksum="85AFFDA46DA69CED" modified="2018-12-05" version="1">MIRQEDIAKKLNISRTTVARALNGTGSVNEETKEKVLKACEELGYKRNPISSSLALKKKKNIYAFIVKAKNNYYTDDIKLGFQKAQGEFKFYKYQLNIIETDIDSPREQLDELKGVIDKGDIDGVIITPLLKEEIKLLKRNNPNIFFIALDLPLDNVTFNIYSNYYKSGRLTAELLQNVLNQGEEILLIDTEDDRISSKPYYYGFYEKITEDNICKIANIVYQSDLKNNIGKVIKDNLTDNVKAIYSSRFLVDIVEYVIKNTDRKLKIVANGLSDNTKKLIESNNIIATVKEKYKELGYISAKVMFEHLYKDIKPKHINIELESEIILKENLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCI4</accession>
    <name>A0A386PCI4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03905</name>
        <name evidence="3" type="ORF">EI377_14430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Seyboldt C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675514.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01551"/>
    <dbReference type="EnsemblBacteria" id="AYE33673">
        <property type="protein sequence ID" value="AYE33673"/>
        <property type="gene ID" value="CP523_03905"/>
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    <dbReference type="EnsemblBacteria" id="QAS61831">
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        <property type="gene ID" value="EI377_14430"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phosphorylation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="AYE33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61831.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="338" mass="37561" checksum="D08B72A4B15F786F" modified="2018-12-05" version="1">MSTVLVLGEVLLRLTPPNNLKISQANTLDICFGGAEANVAVGLSHLGVNTRILTCLPPNELGESAKGFLKSHSVDCDNIVIKGERLGLYYYEEGCSSRKANVIYDRKYSSITELKYEDINVDEVLKDVKLLHVSGITFGLNDEVREVAARIIEEAKSKNIKISVDLNYRSKLFKSYEEFVSIMKPIVKDSYLCFGWLSRDVKNFKVLDPSAVEVTDEMLIDQFKYMTEDLNVKNVATTLRTGTPYNYHSLTGVLFDGDKLYRSSKYEFSMISRIGGGDAFAAGAIKGLISEVNNMQEIIEFATATAVLKQTQIGDVSLSTITEVEELMNNKNLGSVNR</sequence>
</entry>
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 7534</strain>
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    </dbReference>
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        <property type="gene ID" value="CP523_04550"/>
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    </dbReference>
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            <dbReference type="EMBL" id="AYE33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="111" mass="13499" checksum="E0198DF2FB752973" modified="2018-12-05" version="1">MKISIEEKKLTALLKIFYSDYFDEYLNHMIDGDEEQSVVTLFKGMEFFLELVKELGIKFNYSDIKDYIVQEYENGEEIYNNLKKQYNLEFDEYMEKEKDFEDIFGCKLQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCW2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">EI377_14210</name>
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33630">
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        <property type="gene ID" value="CP523_03680"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61794"/>
        <property type="gene ID" value="EI377_14210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="108" mass="12446" checksum="687B870D6D11E07F" modified="2018-12-05" version="1">MGICNILYNVNEIVVKPGLECSYIEFSNKLNKYLICRYGKYYLGLQLYESKDNPCVFYVVASYRDIPCVYKAAPKIGNDISDIYDECWGDSVKRTSILNFVNCKRVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDF7</accession>
    <name>A0A386PDF7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF979 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03065</name>
        <name evidence="3" type="ORF">EI377_13565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01764"/>
    <dbReference type="EnsemblBacteria" id="AYE33517">
        <property type="protein sequence ID" value="AYE33517"/>
        <property type="gene ID" value="CP523_03065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61683">
        <property type="protein sequence ID" value="QAS61683"/>
        <property type="gene ID" value="EI377_13565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03065"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR009323">
        <property type="entry name" value="DUF979"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06166">
        <property type="entry name" value="DUF979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="234"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="32451" checksum="E19041769A786F72" modified="2018-12-05" version="1">MDIAKLSNLLLNIFYIMIGIMMIITMVYTLKDTNHKTRLGTATFWGILATIFIFGEFIPSIVVGGLIVIIGVLGAFNQINVGTIAQLNETFARVKAEKIGIKIFLPSLIIAFVALGIAQFTKLSGVTAIGISAVVAIIITFFITGAKPKEAIVDSDRMLQAIGSTAILPQLLASLGALFAAAGVGDIISNMISGVIPEGNVWIGITAYCVGMALFTAIMGNAFAAFTVITAGIGAPFVFAQGGDPIIASAIAMTAGFCGTLLTPMAANFNILPAVLLDIEDNNGVIKAQSIYAIVLLLIHIPLMYFLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDI9</accession>
    <name>A0A386PDI9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33860">
        <property type="protein sequence ID" value="AYE33860"/>
        <property type="gene ID" value="CP523_04910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04910"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="101" mass="11854" checksum="93516225BF15B214" modified="2018-12-05" version="1">MYYIPYLVIFLGLIFSLLILINHYEKQKSLPSKFIDKQKYFHYMNILFLFVGSIYIILGLLSLFNILSINILTTLTSITTISYLIKMLSITKKYGQQKNNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDK8</accession>
    <name>A0A386PDK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33880">
        <property type="protein sequence ID" value="AYE33880"/>
        <property type="gene ID" value="CP523_05010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017443714" evidence="1">
        <location>
            <begin position="35"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="188"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="290"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="390"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="490"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="588"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="677" mass="74281" checksum="4F67337AC50A33FE" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDR9</accession>
    <name>A0A386PDR9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="9">Holo-ACP synthase</shortName>
            <ecNumber evidence="9">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">acpS</name>
        <name evidence="11" type="ORF">CP523_06530</name>
        <name evidence="12" type="ORF">EI377_01015</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677459.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02183"/>
    <dbReference type="EnsemblBacteria" id="AYE34153">
        <property type="protein sequence ID" value="AYE34153"/>
        <property type="gene ID" value="CP523_06530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59521">
        <property type="protein sequence ID" value="QAS59521"/>
        <property type="gene ID" value="EI377_01015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="10">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="123" mass="13689" checksum="D9900FF9E2EDB8FB" modified="2018-12-05" version="1">MIIGIGTDIIEIERIERAVNKTKNFLEKIFTEKEIKLFQSKNMRAEVMAGNFAAKEAISKAIGTGIRGFSLKDIEILRDELGKPIATLNENIVKILGVNSFRLNITISHNNTSAIAFAILEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDV6</accession>
    <name>A0A386PDV6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CP523_03050</name>
        <name evidence="17" type="ORF">EI377_13550</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678430.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01767"/>
    <dbReference type="EnsemblBacteria" id="AYE33514">
        <property type="protein sequence ID" value="AYE33514"/>
        <property type="gene ID" value="CP523_03050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61680">
        <property type="protein sequence ID" value="QAS61680"/>
        <property type="gene ID" value="EI377_13550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
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            <end position="61"/>
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            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
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            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
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            <end position="186"/>
        </location>
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            <begin position="28"/>
            <end position="188"/>
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    </feature>
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            <begin position="360"/>
            <end position="438"/>
        </location>
    </feature>
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            <begin position="459"/>
            <end position="550"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07694"/>
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        <source>
            <dbReference type="EMBL" id="AYE33514.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61680.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="551" mass="62345" checksum="E825E4ECAA63343E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE30</accession>
    <name>A0A386PE30_CLOSE</name>
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        <recommendedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
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        <name evidence="15" type="ORF">CP523_04130</name>
        <name evidence="16" type="ORF">EI377_14650</name>
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        <name type="scientific">Clostridium septicum</name>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <reaction evidence="1">
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        </reaction>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362698" description="Beta-galactosidase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="2049"/>
            <end position="2068"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
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            <end position="318"/>
        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="13">
        <location>
            <begin position="661"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="14">
        <location>
            <begin position="756"/>
            <end position="857"/>
        </location>
    </feature>
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        <location>
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            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="Big_4" evidence="12">
        <location>
            <begin position="955"/>
            <end position="1007"/>
        </location>
    </feature>
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        <location>
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            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="Big_4" evidence="12">
        <location>
            <begin position="1439"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1993"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2006"/>
            <end position="2046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="2074" mass="230363" checksum="0E5E2B7AEDCAFF89" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE63</accession>
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        <submittedName>
            <fullName evidence="4">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
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        <submittedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Clostridium septicum</name>
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            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673834.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01127"/>
    <dbReference type="EnsemblBacteria" id="AYE34315">
        <property type="protein sequence ID" value="AYE34315"/>
        <property type="gene ID" value="CP523_07590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59709">
        <property type="protein sequence ID" value="QAS59709"/>
        <property type="gene ID" value="EI377_02280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010969">
        <property type="entry name" value="Cys_dSase-rel_unknwn_funct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01977">
        <property type="entry name" value="am_tr_V_EF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="3"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="389" mass="42861" checksum="0A4765AC184B2CFA" modified="2018-12-05" version="1">MSIYLDNASTTFPKPKAVADAIYNFITHIGGNAGRSNHSNSLETNRILFETRSALAEFFNYSFIENVIFTNNITTSLNILIQGSLSKGDHVITSSMEHNSVIRPLYYMKENNNIELDIVNANSQGFINPLDIEKLIKPNTKLIIISQASNVTGSIQPIKEIGLLCKKHNVFFILDTAQGAGVLKTDFSELNLNALAFTGHKSLLGPQGIGGFIIDNKLNKICKPLYLGGTGSLSHDLNQPDFLPDKFESGTLNTPGIIGLLEAIKFINSEGLNTIYEYNNSLHSYFINNLLNINKIKYYGDITGDKSTTCVSFNIDGMDTAEVSYILDNIFEIKNRSGLHCSPLAHKTIGTYPTGTIRLSTSYFTKKEDIDFALSSINKISKKGVETFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE93</accession>
    <name>A0A386PE93_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03375</name>
        <name evidence="4" type="ORF">EI377_13890</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679107.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00065"/>
    <dbReference type="EnsemblBacteria" id="AYE33574">
        <property type="protein sequence ID" value="AYE33574"/>
        <property type="gene ID" value="CP523_03375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61737">
        <property type="protein sequence ID" value="QAS61737"/>
        <property type="gene ID" value="EI377_13890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="31936" checksum="2618FA7E9C786FA2" modified="2018-12-05" version="1">MKEYYKIGEISKIYGIGRDSLMYYEEIGILKPIRDTNDYRLYSISDIWKLNLIKELRELNFSMAKIKEYINNRNITSTKEMLNEEIRLLNKKIIDLNKQKANISKRLKDIEEVIENSLINKVEVVYIKERKALKLNGDISRDVEVDFLVKKLQKEYEEKFYLLGNNHIGAIYNSNKLDKGIYNQYKSVFCLLEDLDEGYNLVLKEGKYVTYSYKGAYSKNKIYLKEMFEFIERNSYEILDDPIEIYKLDVHETSIENEFITEIQIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEE1</accession>
    <name>A0A386PEE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08175</name>
        <name evidence="3" type="ORF">EI377_02930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34403">
        <property type="protein sequence ID" value="AYE34403"/>
        <property type="gene ID" value="CP523_08175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59809">
        <property type="protein sequence ID" value="QAS59809"/>
        <property type="gene ID" value="EI377_02930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="96" mass="10942" checksum="F32DB6A03E82E331" modified="2018-12-05" version="1">MIFKAITVPTPKRIKRYFRKYATKERLLIYSIVGTGIGIIGLNDILAKKLVIGVLIYYGVAYEVIERSDVILSDPIFIEAIIKNQYIGYGMPIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN3</accession>
    <name>A0A386PEN3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02055</name>
        <name evidence="8" type="ORF">EI377_12575</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678871.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00121"/>
    <dbReference type="EnsemblBacteria" id="AYE33328">
        <property type="protein sequence ID" value="AYE33328"/>
        <property type="gene ID" value="CP523_02055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61498">
        <property type="protein sequence ID" value="QAS61498"/>
        <property type="gene ID" value="EI377_12575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="63"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="270" mass="30340" checksum="695DD6A83C7B9C2A" modified="2018-12-05" version="1">MVKRLENFIKKFYLFIIFLFLYAPIFTLIIFSFNDSKSMGKWSGFTLKWYQELFKNERILEALFYTIIIAIISSIVATIIGTLAAIGINKLSGPKKKFLLNINYLPILNPDIVTGIALMSLFIFIRPLTKLDFGFTTMLLAHITFNIPYVVLAVLPKLKQLPANVTDAALDLGATPSYALRKVILPQIKPGIFAGMLMAFTMSIDDFVISFFTTGPGVTNLSIEIFSMARRGIKPEINALSTLMFITVLILLLIANRKDFTSRGDKVEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES8</accession>
    <name>A0A386PES8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssb</name>
        <name evidence="6" type="ORF">CP523_07565</name>
        <name evidence="7" type="ORF">EI377_02255</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673824.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01122"/>
    <dbReference type="EnsemblBacteria" id="AYE34310">
        <property type="protein sequence ID" value="AYE34310"/>
        <property type="gene ID" value="CP523_07565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59704">
        <property type="protein sequence ID" value="QAS59704"/>
        <property type="gene ID" value="EI377_02255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="151" mass="16213" checksum="DE5ADBBA6E876DFE" modified="2018-12-05" version="1">MNKVILIGRLTRDPELNFAANSGTAVTRFSLAVNRPFKKDETDFINCIAFGKTGETIAQYLTKGRQLAVTGSIRTGSYDAKDGTKRYTTDVVVDSFEFIGSGNGGRDQGSSNGGYGYSNPNSDNSSSSNDAFGGMNFDEDMTPVDDGDMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW0</accession>
    <name>A0A386PEW0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase DbpA</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dbpA</name>
        <name evidence="12" type="ORF">CP523_03350</name>
        <name evidence="13" type="ORF">EI377_13865</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DbpA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677204.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02113"/>
    <dbReference type="EnsemblBacteria" id="AYE33571">
        <property type="protein sequence ID" value="AYE33571"/>
        <property type="gene ID" value="CP523_03350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61734">
        <property type="protein sequence ID" value="QAS61734"/>
        <property type="gene ID" value="EI377_13865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00965">
        <property type="entry name" value="DEAD_helicase_DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028619">
        <property type="entry name" value="DEAD_helicase_DbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="216"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in 23S rRNA binding" evidence="6">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="481" mass="54507" checksum="68A5DAE7BA75E2CC" modified="2018-12-05" version="1">MNNKTFKNMGLSEEILKALNNLGFSNPSEVQKEAIPNMLNKEDIIVKSQTGSGKTASFGIPLCEMAIVEETKVQGLILVPTRELAIQVKDDISNIGRLKKVRCAAVFGKQPFNEQIRELKQRVHIVAGTPGRINDHINRGNLNLEHIKYVVIDEADKMLNMGFIDQIGEILDRLPKERNTALFSATLPEEIENLCSKYMKNPKSLTVQSKVFNREKIKESYINIDSNNKDEELCRCLYAHAPEAAIVFCNTKDKVKSLYNELKRDGIKVEQLHGDMEQKDRLNTMERFKNKEFKILVATDIAARGIHVDHITHVFNYEIPMERESYVHRIGRTGRAGKEGFAISFVSNYENKLLEGIEEYIGYKIPMGNLPSQEKVIEGRKVFRESQKELSKNIGNNKKSIHKDVTKLHLTAGKKKKIRPIDIVGCLSNLKELTGEDIGIIDVQDICSFVDILNGKGNEIIKKYKEVSIKGKNVKISKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY0</accession>
    <name>A0A386PEY0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chemotaxis protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_04615</name>
        <name evidence="13" type="ORF">EI377_15170</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01738"/>
    <dbReference type="EnsemblBacteria" id="AYE33804">
        <property type="protein sequence ID" value="AYE33804"/>
        <property type="gene ID" value="CP523_04615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61961">
        <property type="protein sequence ID" value="QAS61961"/>
        <property type="gene ID" value="EI377_15170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="10">
        <location>
            <begin position="415"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="500"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="668"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="702" mass="77798" checksum="65F24BC90361CCF5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF39</accession>
    <name>A0A386PF39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08265</name>
        <name evidence="3" type="ORF">EI377_03015</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674729.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34420">
        <property type="protein sequence ID" value="AYE34420"/>
        <property type="gene ID" value="CP523_08265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59825">
        <property type="protein sequence ID" value="QAS59825"/>
        <property type="gene ID" value="EI377_03015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="19021" checksum="2F6317EBCC97A2EA" modified="2018-12-05" version="1">MQFAIPKVGFRTIKSAISVFLCLVLLPNEPFFACLTAIICLQDTVSSSIKMGINRALGTIMGAIIGLVFMILCRFIHFNTSSSFISKLLIYLIIALGIIVVISTCNIVKKPGAINVACIAFLGVTTIHAFGDPLFYALNRTFETLCGVIISILVNKYITPPKEKHELSKKRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF42</accession>
    <name>A0A386PF42_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01815</name>
        <name evidence="3" type="ORF">EI377_12335</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677299.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33286">
        <property type="protein sequence ID" value="AYE33286"/>
        <property type="gene ID" value="CP523_01815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61457">
        <property type="protein sequence ID" value="QAS61457"/>
        <property type="gene ID" value="EI377_12335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="134" mass="15418" checksum="33055B464908E828" modified="2018-12-05" version="1">MGIMEILSYIFLGLSVLTYIFISIAMYNVAKKKGYNKEWLAWIPIVQDYVVIKYAKGIPWVLLLYIPYFFTTGLLASIISFIIGLYLVIMAVRICKEFNVDYTWLIVGLFIPGVAAISYYKLYKSTIKSEVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF66</accession>
    <name>A0A386PF66_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33884">
        <property type="protein sequence ID" value="AYE33884"/>
        <property type="gene ID" value="CP523_05040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="440" mass="51926" checksum="157F92099F7F1AA4" modified="2018-12-05" version="1">MKGKILKKLNEKTPDFLKKILSKSIRKKVIENSVFMKTLEEITNFEQLDESDKEKIHLEKLKNVLIYAYENTKYYNKVFDKIEFNPYEFKDVNEIKRIPTIDKQFVLDNFEDLISREEIDYYLAYTGGSTGKPLKILLDTDSIYKEKAFVYNYWSKFGYDYKNSRIITLRGLEFNGKIYKYNPIDNQIVLNPFILNENNVEDYIKIINKFKPEFMHGYASAIYNLCRILNKKSLKLNVNIKSVCFVSENVDSGEREYIEKTLNCKSNIFYGHSERIVFAEYEDSTYKFNSLYTHVDLLESNKENIYNIACTGLINKKMPLINYVPDDKVIISDENINIYGHWDKEMLVGKNNELVSMASINFHNEVFKKIKLYQFEQFKNGEVFLNIVEDEILTEKDKSEIINTINKKLKNVIDIKLKIVANIPLTNRGKYKKILQHISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFG6</accession>
    <name>A0A386PFG6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF3427 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03610</name>
        <name evidence="6" type="ORF">EI377_14140</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02223"/>
    <dbReference type="REBASE" id="297095">
        <property type="entry name" value="CseVAT12ORF14140P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33618">
        <property type="protein sequence ID" value="AYE33618"/>
        <property type="gene ID" value="CP523_03610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61782">
        <property type="protein sequence ID" value="QAS61782"/>
        <property type="gene ID" value="EI377_14140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="235"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="430"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="964" mass="112386" checksum="6966B16EAD223768" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFH0</accession>
    <name>A0A386PFH0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">flhA</name>
        <name evidence="9" type="ORF">CP523_02530</name>
        <name evidence="10" type="ORF">EI377_13065</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673937.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00461"/>
    <dbReference type="EnsemblBacteria" id="AYE33416">
        <property type="protein sequence ID" value="AYE33416"/>
        <property type="gene ID" value="CP523_02530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61590">
        <property type="protein sequence ID" value="QAS61590"/>
        <property type="gene ID" value="EI377_13065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="688" mass="75758" checksum="06C74C1C8E402331" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ2</accession>
    <name>A0A386PFJ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal-processing cysteine protease Prp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10655</name>
        <name evidence="2" type="ORF">EI377_05440</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674148.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01371"/>
    <dbReference type="EnsemblBacteria" id="AYE34825">
        <property type="protein sequence ID" value="AYE34825"/>
        <property type="gene ID" value="CP523_10655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60220">
        <property type="protein sequence ID" value="QAS60220"/>
        <property type="gene ID" value="EI377_05440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="128" mass="14490" checksum="DEBABD0879F40D46" modified="2018-12-05" version="1">MIKITIFKKDNLTLGFKIKGHALSREEMKRATGEVFDLVCNSVSVLSQSAVIGMEEVLKLPVKYEINDGFLNINLSNLDLEEIKSAQVILLTFEKSLESLMMTLKTSFGKNKDSEYIKLLKEEVQEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ9</accession>
    <name>A0A386PFQ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-type HAD-IIB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03010</name>
        <name evidence="2" type="ORF">EI377_13510</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678444.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01775"/>
    <dbReference type="EnsemblBacteria" id="AYE33506">
        <property type="protein sequence ID" value="AYE33506"/>
        <property type="gene ID" value="CP523_03010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61672">
        <property type="protein sequence ID" value="QAS61672"/>
        <property type="gene ID" value="EI377_13510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="32477" checksum="950AF4A34B1A56FC" modified="2018-12-05" version="1">MRLFITDLDGTLLDDCQNISYENAKALKDVQAKGIEVIPCTGRPFLDAYNILKSANLYPNYIISSNGAMVHKSTGEKLASYPIEKKDAKLVLDYMDKNNFPYSVFTEDIIFQKDDNSKRLKYDYNNTEELNSPLANMGFTTLLELFTVENKSIVRVSNYEEILSSNKELFYIAANSFNQERLDNGRKDLSHIKSLNISSSAFHNFDATNINASKGKALEFLANYLNIELKDVVAIGDNYNDISMLEKVKYSIAMGNANKEVKNICRYTTLENYKNGVAYAIRKYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW2</accession>
    <name>A0A386PFW2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnpA</name>
        <name evidence="6" type="ORF">CP523_07655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673859.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01140"/>
    <dbReference type="EnsemblBacteria" id="AYE34327">
        <property type="protein sequence ID" value="AYE34327"/>
        <property type="gene ID" value="CP523_07655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="116" mass="13705" checksum="30866DA6396C1282" modified="2018-12-05" version="1">MIYRIRKNNEFRTVYKRGKSLANGLLVLYIFNNRRNINEEGHYYNRIGVSVSKKVGNSVIRSRSKRLISESYRLNCENLKNGYDFVFIARTSIKDKTYFEVEDAMKKLFSKAGLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX4</accession>
    <name>A0A386PFX4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ORF">CP523_00730</name>
        <name evidence="6" type="ORF">EI377_11225</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674644.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02374"/>
    <dbReference type="EnsemblBacteria" id="AYE33079">
        <property type="protein sequence ID" value="AYE33079"/>
        <property type="gene ID" value="CP523_00730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61248">
        <property type="protein sequence ID" value="QAS61248"/>
        <property type="gene ID" value="EI377_11225"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="20626" checksum="6B242378878D9D6F" modified="2018-12-05" version="1">MIKGIIKTAEEKMQKTISVLQKDLSTMKAGRANPTMLDRIQVDYYGSLCPLNQVANISAPEPRVLVITPWEKNILKDIEKAILVSDLGINPSNDGSIIRLIVPELTEETRKNLVKNVKKTGEDAKIALRSIRRDANDKIKALKKDGDISEDEVKSAEENVQKVTDSFVKEIDAIIVAKEKEIMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY9</accession>
    <name>A0A386PFY9_CLOSE</name>
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        <submittedName>
            <fullName evidence="6">Restriction endonuclease subunit S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_04585</name>
        <name evidence="7" type="ORF">EI377_15140</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675831.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01744"/>
    <dbReference type="REBASE" id="297235">
        <property type="entry name" value="S.CseVAT12ORF15145P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33798">
        <property type="protein sequence ID" value="AYE33798"/>
        <property type="gene ID" value="CP523_04585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61956">
        <property type="protein sequence ID" value="QAS61956"/>
        <property type="gene ID" value="EI377_15140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="228"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="395" mass="45403" checksum="E9B0CFBC909A4B13" modified="2018-12-05" version="1">MKYKLSDIFQKPISGEWGSELEEGKKGVKVLRTTNFTNLGRLNLNDVVEREIDINKHRSKILKQGDIIIEKSGGSPTQPVGRVVIFEEGGNEIYFCNNFTSILRPQKLINSKYSLYLMKDLYNKRKVLKYQNKTTGIINLKLADYIANTEIILPTINVQIKIAKVLDKAQELIDKRKEQIQALDELTKSQFIEMFGTLKNEHKLPLEKCTTFIDYRGKTPTLSESGIRIINAKSVGNGFFKYIDEYISEETYDSWMKRGFPVAGDVLFVTEGHTFGNVCRIPNDLNKFAMGQRVITMQGKEKLLNNVFLAQYMQSMPFKIDIDKYKTGSSAQGIRSKELQKILIPIPNIELQNQFADFVKQTDRLKLKMEKSLKELEDNFNSLMQRAFNGELFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG39</accession>
    <name>A0A386PG39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03710</name>
        <name evidence="6" type="ORF">EI377_14240</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677689.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02203"/>
    <dbReference type="EnsemblBacteria" id="AYE33636">
        <property type="protein sequence ID" value="AYE33636"/>
        <property type="gene ID" value="CP523_03710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61800">
        <property type="protein sequence ID" value="QAS61800"/>
        <property type="gene ID" value="EI377_14240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="316" mass="36029" checksum="83B47920FFE3706D" modified="2018-12-05" version="1">MTNIYDIAKKSGFSPSTVSRALNNNSRISKETRTIICNIANEMNYVPNNKAISLSTGKSYTLGVIIPYITYNSYYDSIINSIIYESFKMNYRVTFLPTNYQKDIEIDYLKLLSTKEFDGIIISSAANSYDTIEKYLKYGHIVSCEYTDNSSIPSVIIEKTKTYKYILQILKDNNIENIGVTFSRNINSSLNSQNTYSTFCENLINFNEQNTFPNCRTFDDGIKAATYFHKFIPKLQCIFANSDEIASGIYWYFNTHEKKVPIIIGQDNSSISKVLNFSTIDFNLNLLGSEAVKLCISGVKEKKIITATFINRTIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG73</accession>
    <name>A0A386PG73_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative DNA modification/repair radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03145</name>
        <name evidence="6" type="ORF">EI377_13660</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677276.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02155"/>
    <dbReference type="EnsemblBacteria" id="AYE33532">
        <property type="protein sequence ID" value="AYE33532"/>
        <property type="gene ID" value="CP523_03145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61695">
        <property type="protein sequence ID" value="QAS61695"/>
        <property type="gene ID" value="EI377_13660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="445" mass="50835" checksum="A4D68AB995CE8858" modified="2018-12-05" version="1">MNINEKLRILSAAAKYDVSCSSSGSKRKNKNGIGNTSSNGICHSFTPDGRCISLLKILLTNICIYDCKYCINAVSKDIERAAFTPEEIIELTINFYKRNYIEGLFLSSAVFKSPNYTMELLLKIVKKLRINENFNGYIHLKVIPGADDILIKEAGKYVDRMSVNIELPSSSSLKLLAPQKKKENILKPMGLITSSITENTDLKRKFNYANSFVPGGQSTQLIIGATPESDFKILNLSENLYNKYKLKRVYYSAYVPVIKNNKFLPNITHPPLIREHRLYQADWLLRFYGFKANELLNNENDNFDLNFDPKTSWALNNINYFPIEINKASYEMLLRIPGIGVISAKRILLTRKVHSLSFDDLKKLGIVLKRAQYFITCRGKYYGDVNFDNEKIKNRLLYFDKPNIDKELSKQISFFDDISTNGILLNKSPKILLPKDTITSITGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG75</accession>
    <name>A0A386PG75_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11810</name>
        <name evidence="3" type="ORF">EI377_06630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673412.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02920"/>
    <dbReference type="EnsemblBacteria" id="AYE35043">
        <property type="protein sequence ID" value="AYE35043"/>
        <property type="gene ID" value="CP523_11810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60436">
        <property type="protein sequence ID" value="QAS60436"/>
        <property type="gene ID" value="EI377_06630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="166" mass="19287" checksum="23A1F5719766E4A0" modified="2018-12-05" version="1">MKYYNTNIENFVLRETSVEDIQIILSLIKDIAEYENMLDQVIATEDSLRESIFENNRAKVLLGELDGKVVGYALYFYNFSTFVGREGLYLEDIFINPKVRGKGLGKEIFKVLGKIAKKNGCKRMEWVCLDWNKPSINFYKSLGAKAMDEWTIYRLTDNEIEKLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG76</accession>
    <name>A0A386PG76_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-[acyl-carrier-protein] reductase FabK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fabK</name>
        <name evidence="2" type="ORF">CP523_01255</name>
        <name evidence="3" type="ORF">EI377_11755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674354.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02267"/>
    <dbReference type="EnsemblBacteria" id="AYE33179">
        <property type="protein sequence ID" value="AYE33179"/>
        <property type="gene ID" value="CP523_01255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61349">
        <property type="protein sequence ID" value="QAS61349"/>
        <property type="gene ID" value="EI377_11755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017569">
        <property type="entry name" value="Enoyl_ACP_red-II_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03151">
        <property type="entry name" value="enACPred_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="79"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="312" mass="33277" checksum="B465948BFC45255F" modified="2018-12-05" version="1">MKSTRINKLLGIKYPIFQGGMAWIADASLAAAVSEAGGLGIITGIAPVEWVRSEIRKAKELTNKPFGVNIMLMADNVEEIAKLVCEENVKVVTTGAGSPGKYMDMWKEAGITVIPVVASVALAKRMEKAGADAIIAEGTESGGHVGQLTTMALVPQIVDAVEIPVIAAGGIGDGRGVAASYMLGAEGVQLGTRFLVAKECTVHKNYKDKVLAAKDIDTDVTGRITGHPVRVLRTKLSREFIKLEKAGDIEKMEELGRGALARAAKDGDLDRGSVMAGQISGLINKEQSAKEIIDEIFLEADNVFRSFRRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG82</accession>
    <name>A0A386PG82_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07150</name>
        <name evidence="2" type="ORF">EI377_01905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673716.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34244">
        <property type="protein sequence ID" value="AYE34244"/>
        <property type="gene ID" value="CP523_07150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59650">
        <property type="protein sequence ID" value="QAS59650"/>
        <property type="gene ID" value="EI377_01905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="100" mass="11865" checksum="AA49809A7DC58D4A" modified="2018-12-05" version="1">MPKKTSKNNDLLNSVKRTTAPKIYSLLVELVNDEREDLAEMVLKIDYLLKYTSNCINHKDFEEAKESLQRAEERIKLLKEEHIDIDYLQYLYDGIKKKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA9</accession>
    <name>A0A386PGA9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_12145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673544.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02985"/>
    <dbReference type="EnsemblBacteria" id="AYE35105">
        <property type="protein sequence ID" value="AYE35105"/>
        <property type="gene ID" value="CP523_12145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="35"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="280" mass="32261" checksum="03049722A55D0BE7" modified="2018-12-05" version="1">MPSLILEGGTFRPIFSAGVMDALLDNDVMFPYCIGVSAGITNGFSYLSRQKRRNLDILESYRNDKRYLSVKNFFKCKSLFGLDFIFDEIPNKLSPFDMDTFLKYNGTALVGVTNAITGQTEYLDGKTIDEKCTILRATCAIPLFFPAIRINNNYYYDGGICDPIPIQKAISDGNEKHLIILTRPKGYRKQFSRKNLFASKILTKKYPELNNSLLNRHRLYNEQVEFCEKLEREGKALILRPRENQAIESFEKNVDKLREGYFNGYNLAIEKMDEIKNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD2</accession>
    <name>A0A386PGD2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_10730</name>
        <name evidence="8" type="ORF">EI377_05515</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674119.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01356"/>
    <dbReference type="EnsemblBacteria" id="AYE34840">
        <property type="protein sequence ID" value="AYE34840"/>
        <property type="gene ID" value="CP523_10730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60234">
        <property type="protein sequence ID" value="QAS60234"/>
        <property type="gene ID" value="EI377_05515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="34892" checksum="E940846072BE877E" modified="2018-12-05" version="1">MVKFIIKKLLGLIPMLLLITFIIYLGLELTPGDAVSHMISPELLANADPNKLDEIRAAYGLNDPFILRYFRWLGEILRGNFGYSVSSGVAIKDILKDLLPATLELAIAALLISTILGSLLGLFSAIRRGTLTENLLTVAGMIGVSIPQFFFGMVCILIFSLNLGWLPVGGRMMPGKTAFIDRYEYLILPALVLGISLTAGVMRYARSSMLDTMNKEYIRTARSKGLPEWKVNLIHGFRVALTPVIVLIGFRLPTLIGGAVIIETVFRWPGIGSAFATAVRAQNYPLVMIIALLTVTAVLVSSFLVDVLTALLDPRVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI9</accession>
    <name>A0A386PGI9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panC</name>
        <name evidence="6" type="ORF">CP523_07830</name>
        <name evidence="7" type="ORF">EI377_02520</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02101"/>
    <dbReference type="EnsemblBacteria" id="AYE34344">
        <property type="protein sequence ID" value="AYE34344"/>
        <property type="gene ID" value="CP523_07830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59740">
        <property type="protein sequence ID" value="QAS59740"/>
        <property type="gene ID" value="EI377_02520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07830"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="281" mass="31542" checksum="B2FB3450F33DCA0A" modified="2018-12-05" version="1">MRILKSIKEVREQIKLWKRDGLTVGLVPTMGYLHEGHESLIKRAAKENDKVVVSIFVNPMQFGPAEDLDNYPRDLDGDSCICEGAGADLIFNPDAKEMYFNDFSTFVDMNGLTQGLCGKSRPVHFRGVCTVVLKLFNIAPANRAYFGEKDAQQLAIIKRMVRDLNIDIEIIGCPTVRESDGLAKSSRNFYLSQEERKAANILNKSLELAKIKLCSGEKSAKAIRDIIIENIKKEPLAKVDYVEVVDSKSMERIEKIDRSILVAIAVNIGKARLIDNFTFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGK8</accession>
    <name>A0A386PGK8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dockerin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05770</name>
        <name evidence="4" type="ORF">EI377_00255</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674950.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34008">
        <property type="protein sequence ID" value="AYE34008"/>
        <property type="gene ID" value="CP523_05770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59380">
        <property type="protein sequence ID" value="QAS59380"/>
        <property type="gene ID" value="EI377_00255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016134">
        <property type="entry name" value="Dockerin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00047">
        <property type="entry name" value="LYZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51766">
        <property type="entry name" value="DOCKERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788368" description="Dockerin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Dockerin" evidence="2">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="584" mass="66531" checksum="7E541314534CCD73" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM8</accession>
    <name>A0A386PGM8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08020</name>
        <name evidence="3" type="ORF">EI377_02780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00719"/>
    <dbReference type="EnsemblBacteria" id="AYE34374">
        <property type="protein sequence ID" value="AYE34374"/>
        <property type="gene ID" value="CP523_08020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59780">
        <property type="protein sequence ID" value="QAS59780"/>
        <property type="gene ID" value="EI377_02780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="156" mass="18425" checksum="F37DD8BC769CC93E" modified="2018-12-05" version="1">MKINNNKIKYKVSSFYDLTRDDIYEVAKCRYEVFACEQKIVCENDFDDKDQEAYHLLAYYEEKLVGYCRILKSGATYDKPSIGRVLVLKEYRRNNIAQEMMMKAVEFIENEMGEKEIVLSAQLYVKDLYSSIGFKSISNVYDEAEIPHIKMSFKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS0</accession>
    <name>A0A386PGS0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676491.1">
        <property type="nucleotide sequence ID" value="NZ_CP023671.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33742">
        <property type="protein sequence ID" value="AYE33742"/>
        <property type="gene ID" value="CP523_04270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="143" mass="16744" checksum="72A33F4AB9623C8B" modified="2018-12-05" version="1">MVMLYDKKVLLYNIKDGKVEAVYEKRLGSRYGQSDVSYRLGINTKDEKISIINYDSKNAWQEELIEIITLENGKVVIKKLYAKAKKDNDIPVRDNLVEFFIDDKPITLDNYNSIYNSTVKHHVLQDLFMQLAVKLMQLFCILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGS1</accession>
    <name>A0A386PGS1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12980</name>
        <name evidence="4" type="ORF">EI377_07855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677804.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02536"/>
    <dbReference type="EnsemblBacteria" id="AYE35263">
        <property type="protein sequence ID" value="AYE35263"/>
        <property type="gene ID" value="CP523_12980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60658">
        <property type="protein sequence ID" value="QAS60658"/>
        <property type="gene ID" value="EI377_07855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362758" evidence="1">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="305" mass="33256" checksum="82E64AA03A3CF328" modified="2018-12-05" version="1">MKKRNRILSLVSTLLFAIMLLVGCGKTEVTMKDREGTEFKVPKKVNTIISTAPSNTEVLVELGLSDKLVAIDKYSADVEGVNQDLPKIDFRNPDAETIIALKPDLIIASGHNKAGDKDPFALIKEAGIPVAYIPSSYSIDGIYGDIEFISKLTGTEKKGNEIINNMKKEVADIKAIGDKITDKKKVYFEIGSGSKLSSFGKDTFLNEMIEIIGAENIFANEKSWISPSPESIIAANPDVILTNMPEVNGVKAVDDIKSRAGWENVKAVKDGAVYGIDKNTSARPSQNVIKALKEMAKAVYPNEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT2</accession>
    <name>A0A386PGT2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMPK1_CBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11460</name>
        <name evidence="3" type="ORF">EI377_06275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673296.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34980">
        <property type="protein sequence ID" value="AYE34980"/>
        <property type="gene ID" value="CP523_11460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60373">
        <property type="protein sequence ID" value="QAS60373"/>
        <property type="gene ID" value="EI377_06275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMPK1_CBM" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="230" mass="27081" checksum="CA5EC108A4662EB3" modified="2018-12-05" version="1">MNITFRYEENESLIINKISVIGSFNNYDVNSGKMEKKDGVWILEASLEPGEHYYKFVINDKLKLNDSTANIYLPHINDEIYSVIMINENDERLYNNTQYTANIEKYNMTGNIYEEYIPTNKKEFNRNIDKKVVTRFQFTNVTGIHAVTAVWVMPNGELFDDSENLLFTPKGEEDKPIDIWFWIDLTDSDRNYQSGRWLMKLFLDGEFILEDEFTLGKANTYSNYGQVKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGZ2</accession>
    <name>A0A386PGZ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YihY/virulence factor BrkB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677467.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02188"/>
    <dbReference type="EnsemblBacteria" id="AYE34158">
        <property type="protein sequence ID" value="AYE34158"/>
        <property type="gene ID" value="CP523_06555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="283" mass="32206" checksum="44DD5E33C05B781F" modified="2018-12-05" version="1">MKNEEPGKKRSTLDFLIYFIVKVKNDDIFALASQLAYYLILSFFPFLIFLMTLIGFSNLNSMEVLDGLRSILPSSVFELVSKIVIEVVDTQYTGLLGASIAITIWSASSGFRAVIKGINKAYNMEEDRSFFKRVIVAIFFTFTLALIIILTLAMLVFGDVIGDYLISVLPFKDIIETLWNLTRYVIIVFIMTWIFACIYRYTPATKRKWREVFPGAIISTLGWIGVSLGFSYYINNIANYSRFYGSLGAVFVLMTWLYITSMILILGAEINSVLALRKKQSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH54</accession>
    <name>A0A386PH54_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12220</name>
        <name evidence="3" type="ORF">EI377_07040</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673572.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35120">
        <property type="protein sequence ID" value="AYE35120"/>
        <property type="gene ID" value="CP523_12220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60511">
        <property type="protein sequence ID" value="QAS60511"/>
        <property type="gene ID" value="EI377_07040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="142" mass="16306" checksum="29A765291E4FE718" modified="2018-12-05" version="1">MNSAFDSFEIAMLIKEIYAKSIKVISDGLKDSGLTHQQIMVIKIIAHNGEVIISDICEEMSLAKGTVSGIVRRLEEAGYVEKVKHEGDKRNTYVRFSAKGREFAKEFRFTINKSFDEIFKNFTDEELLRVKNELKVLKEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH91</accession>
    <name>A0A386PH91_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ORF">CP523_14080</name>
        <name evidence="16" type="ORF">EI377_08985</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03092"/>
    <dbReference type="EnsemblBacteria" id="AYE35465">
        <property type="protein sequence ID" value="AYE35465"/>
        <property type="gene ID" value="CP523_14080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60853">
        <property type="protein sequence ID" value="QAS60853"/>
        <property type="gene ID" value="EI377_08985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14080"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="298"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE35465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS60853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="366" mass="41031" checksum="2F78C5F52509D06A" modified="2018-12-05" version="1">MDEIFMSRALELAKKGEGYVNPNPLVGAVIVKNGKVIGGGYHKIFGKEHAEINAINNTNEDLAGAIMYVTLEPCCHYGKTPPCVEAIKRHKIKKVVVGTLDFNPLVKGKGVKFLKEEGVEVVVGVLEEKCQRLNEIFNHYIINKQPFIALKWAMTIDGKIATAKHKSRWITNEKSREFVHSLRKKYKGIMVGINTILKDNPDLRYRGDDINEYLSNHFRVVLDSSLKIPIESLVLKNQSSSKTLIFTTRLADKNKKIVLKSNGIEVIEVNDKNGQVNLKEVMKKLGERNVDSILVEGGGNLNYSFLEEGLVNKVYTFIAPKIFGGEKALTPVEGLGIKEVKESYNLKFQEIRSFNEDLLVIGNFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH95</accession>
    <name>A0A386PH95_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Crp/Fnr family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_03230</name>
        <name evidence="5" type="ORF">EI377_13745</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02137"/>
    <dbReference type="EnsemblBacteria" id="AYE33549">
        <property type="protein sequence ID" value="AYE33549"/>
        <property type="gene ID" value="CP523_03230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61712">
        <property type="protein sequence ID" value="QAS61712"/>
        <property type="gene ID" value="EI377_13745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="26565" checksum="A03DE081D4D0C644" modified="2018-12-05" version="1">MKFIKEEQLRSMETFKDVSDRTIEKLCSLGEITCYLKGSHIFRDKDEVKKIYIVYSGKVALYKMNESAQKKVVFILGEDRIINAVVIDNLPASINCEIFENAEILSFDRNKFIEIMESDFELSKVVIRSLAIKVRRLYRQMKNSTPIKVEKRVAAKIWKLAKDYGIESEDGVLIDLNISITYLADMFGMPRETISRAVKILQKEGLIIHKNKKLVVRDREKLSNFFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA9</accession>
    <name>A0A386PHA9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14070</name>
        <name evidence="7" type="ORF">EI377_08975</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03090"/>
    <dbReference type="EnsemblBacteria" id="AYE35463">
        <property type="protein sequence ID" value="AYE35463"/>
        <property type="gene ID" value="CP523_14070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60851">
        <property type="protein sequence ID" value="QAS60851"/>
        <property type="gene ID" value="EI377_08975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="292" mass="34065" checksum="45CF7ABBF257CD25" modified="2018-12-05" version="1">MRFKKVYIETTNICNLSCNFCPKTKRKYKFMNENEFLHIIKEVKPYTNYIYLHLMGEPFLNSNLEKFLDISYKNDLKVNITTNGTLINNVKEILLKSKALRQVNISLHSFEANDQDVNFNEYLENIINFINEANEKSNIICSLRLWNMDTVEMKASNSLNNCIFRLLEEKLNLNISIKESLKDKLGIKLRKNLYLNTAEKFNWPNINLLEEEEEVFCYGLRDQIGILVDGTVVPCCLDSEGNIPLGNIFNSSMEKIINSDRAIKIYEGFSKRKAVEDLCKKCGYAKRYKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD4</accession>
    <name>A0A386PHD4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMP family ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03460</name>
        <name evidence="6" type="ORF">EI377_13985</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677901.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02243"/>
    <dbReference type="EnsemblBacteria" id="AYE33589">
        <property type="protein sequence ID" value="AYE33589"/>
        <property type="gene ID" value="CP523_03460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61753">
        <property type="protein sequence ID" value="QAS61753"/>
        <property type="gene ID" value="EI377_13985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362719" evidence="3">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="4">
        <location>
            <begin position="36"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="360" mass="38779" checksum="29B7122949F41582" modified="2018-12-05" version="1">MKKRVIALALSAFMVTGLVGCGKSENPETGDANLKVGMVTDSGTIDDKSFNEGTWTGVTKATDELKLEKKYLQPNGETHADYIKEITNLYDAGFKLIVTPGFKFETAIYEAQEKYKDAKFVLIDGAPKKDDKSEASVADNTVSIFFAEEQSGFIAGVATALQIKEGELGFIGGMEIPPVQKFNWGFQQGVKYANENLGTKASIKKENVVYQGTFNDVPAGQQIANKMYNSGVKAIFCSAGGTGVGAINAAKAKVEKGEEVWIIGVDVDQYSHGIYEGDKSVILTSAMKKIDHAAADMIKAEKEGKFPGGKTLTYDVNNDGVGLPEKNPNLSEDTIKKVNEVLEKIKSGEIKVSAEKGDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH1</accession>
    <name>A0A386PHH1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">CP523_07660</name>
        <name evidence="8" type="ORF">EI377_02350</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673861.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01141"/>
    <dbReference type="EnsemblBacteria" id="AYE34328">
        <property type="protein sequence ID" value="AYE34328"/>
        <property type="gene ID" value="CP523_07660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59723">
        <property type="protein sequence ID" value="QAS59723"/>
        <property type="gene ID" value="EI377_02350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="44" mass="5434" checksum="F03C55E05A17F4F1" modified="2018-12-05" version="1">MFMTYQPKKRQRKKEHGFRKRMSTQGGRNVLKRRRQKGRKKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI5</accession>
    <name>A0A386PHI5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">CP523_12960</name>
        <name evidence="12" type="ORF">EI377_07840</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678210.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03020"/>
    <dbReference type="EnsemblBacteria" id="AYE35260">
        <property type="protein sequence ID" value="AYE35260"/>
        <property type="gene ID" value="CP523_12960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60655">
        <property type="protein sequence ID" value="QAS60655"/>
        <property type="gene ID" value="EI377_07840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12960"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="314" mass="35098" checksum="7ED805EB549F99BE" modified="2018-12-05" version="1">MIDLTIGFLLDLIIGDPQNPIHPVRIIGNLCRVLENFFRSIMKKYLKLAGLITWIIVVLAVYFINYIIIKFILNINIVAGVIFSGILIYFCISAKGLKVEGLKVYNYLIKNDIECARKQLSYIVGRDTKSLDKKGIIRAVVETIAENMSDGVIAPLFYAGIGGAPLAMAYKAVNTMDSMFGYKNDKYMEFGFFPAKLDDVFNYIPARITGLLTVLTAFILKLNWKNSFKIYNRDKYNHTSPNSAHPEAAVAGALGIKLGGANYYFGKLVEKPTIGDKLKEIELSDIDSTNKILYGVAILGYILGILINLIWRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ0</accession>
    <name>A0A386PHJ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14490</name>
        <name evidence="7" type="ORF">EI377_09465</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676842.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02491"/>
    <dbReference type="EnsemblBacteria" id="AYE35543">
        <property type="protein sequence ID" value="AYE35543"/>
        <property type="gene ID" value="CP523_14490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60929">
        <property type="protein sequence ID" value="QAS60929"/>
        <property type="gene ID" value="EI377_09465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="335" mass="37265" checksum="0308929F5D8F6E0E" modified="2018-12-05" version="1">MSKLLEVKDLRTSFSTHAGEVQAVRGVTFHLDRGEALGIVGESGCGKSVTMMSIMRLLSDNGKLVSGEIYFNGKDLSTAKEKEMESIRGNDIGMIFQDPMTSLNPVFTVGDQLVEPLMKHRKVSKKEAWNQAIKMLELVGIPSPENRMKQYPHEFSGGMRQRVMIAMSLICEPKLIIADEPTTALDVTIQAQILDLMKDLKEKLNTSIILITHDLGVVADLCTRINVMYGGIVVETGTTEDIFYRGRHPYTWGLLNSVPNPKSDVKEKLQPIEGQPPDLLKPPVGCPFAARCKYAMKVCLQKQPPLFDIAEGHKAACWLCHENAPKVESSIRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ8</accession>
    <name>A0A386PHQ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677511.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35330">
        <property type="protein sequence ID" value="AYE35330"/>
        <property type="gene ID" value="CP523_13335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="203" mass="23696" checksum="364BD44CE273A994" modified="2018-12-05" version="1">MVVLSEDEKNIPICDTNILISFGLSDFIGEFIDFNKKIFVADNVLLELERKFNRNTEYSYLLQNVKNNENINVINKDEYFTEDRILVMNASLNQYKLIEDCLLTGDLCPDSGEFISAIYAANLEIRKFITNDLKFINKYKDEFIFKGLSFINMTQVLDKIIGKEKRKGVVLDINRKSKEMEDTLTKEKVLEKFEKWSLKLSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHS2</accession>
    <name>A0A386PHS2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_11120</name>
        <name evidence="10" type="ORF">EI377_05910</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677070.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00916"/>
    <dbReference type="EnsemblBacteria" id="AYE34917">
        <property type="protein sequence ID" value="AYE34917"/>
        <property type="gene ID" value="CP523_11120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60311">
        <property type="protein sequence ID" value="QAS60311"/>
        <property type="gene ID" value="EI377_05910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11120"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="5"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="30311" checksum="8C77D6BEDEFF0153" modified="2018-12-05" version="1">MHMMDYHIHSDNSFDGKDSVVSICESAIMAGLNEICFTDHFSLKEDLKTYGTLNMKKYSDEISHCKEIFKNNLIIKAGLEICEPHETENELKETISNIPFDFILGSIHNFDHTGLSTYMRAHDKETSYEDYFRDVDKISTSPFIDVVAHIDLMKRYAFVKHGKYDFNTHKEIIEQILKNIIKRGKGIEVNTSTLRSEINETMPSIDTLKMYKDLGGEIITIGSDAHCTKDVAAGIKESLELLKEVGFENIYTFDERKPIIHKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT6</accession>
    <name>A0A386PHT6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678560.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03120"/>
    <dbReference type="EnsemblBacteria" id="AYE35675">
        <property type="protein sequence ID" value="AYE35675"/>
        <property type="gene ID" value="CP523_15235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="267" mass="32431" checksum="AB332F31DA3FFB4B" modified="2018-12-05" version="1">MFYRQKVYKLIKKMNVKTKESQEVLDISMFPITMFEKKKSRKRKKRESRVVQKNLNDKNAKKYFYRKVQCNFDTSDYIWCISYDKKPKNDEEANRDFENLIRRINNYRKKKGLERTRYMAVKEGGEGTKKRIHYHIIIDGDIDRNTLESFWKKGYSNTRTLRAREDGFKDLTQYMTKEGNSKKRWKCSRGNLVEPQAMINDNRFSRKKMREMLTQHPSREEIEALYPGYTLTDYSIKYNEENGGVYMNILMRRTVKNYLDKRRKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW5</accession>
    <name>A0A386PHW5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04360</name>
        <name evidence="3" type="ORF">EI377_14895</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676459.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00406"/>
    <dbReference type="EnsemblBacteria" id="AYE33759">
        <property type="protein sequence ID" value="AYE33759"/>
        <property type="gene ID" value="CP523_04360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61916">
        <property type="protein sequence ID" value="QAS61916"/>
        <property type="gene ID" value="EI377_14895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="26289" checksum="76AB34E3CC307B49" modified="2018-12-05" version="1">MDINRRSITIKISIIIILILAIIFIPNKYNSEKVQVYLEGEAIVYDGILSNEGNKEAFRLYTKNINRLIINSEGGEINTSLELAEWVYDRNLDIEIKNKAFSTVASYVFVAGNNKYLHKDSVIRWDNNLNDKKNIISNIFFKEYLKEIDEREEEFFEKINVDKRSVTYGSNLDFEKYEDSGKYVGWTYGLSALEKLGIKNVKLIDGVWNPNDNMKEKKIFTITDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI03</accession>
    <name>A0A386PI03_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04590</name>
        <name evidence="6" type="ORF">EI377_15145</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01743"/>
    <dbReference type="REBASE" id="297234">
        <property type="entry name" value="M.CseVAT12ORF15145P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33799">
        <property type="protein sequence ID" value="AYE33799"/>
        <property type="gene ID" value="CP523_04590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61957">
        <property type="protein sequence ID" value="QAS61957"/>
        <property type="gene ID" value="EI377_15145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="3">
        <location>
            <begin position="139"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="487" mass="55444" checksum="BE1C133B5E061364" modified="2018-12-05" version="1">MITGELKSKVDKIWETFWTGGITNPLEVIEQFTYLLFIKGLDDVETTKEAEASILSIDFERTFPEDKQHLRWSKFSNEGDPEKMYLIVQNEVFPFIKNLHGNKESAYAKYMGDAIFKIPTPLMLSKIVDGINNIKFEKDKDTKGDLYEYLLSKVATAGTNGQFRTPRHIIDMMVNLMKPTPEDIIIDPAAGSAGFLVSSQQYLRQNHADLFLVQGLKEHFNNNMFYGFDMDRTMLRIGAMNMMLHGVDNPNIEYKDSLSEVNTDNDKFTLVLANPPFKGSLDYEAVSADLLKVTKTKKTELLFLALFLRILKAGGRCASIVPDGVLFGSTGGHKSIRKEIVENHKLEAIISMPSGVFKPYAGVSTAIMIFTKTGTGGTDKVWFYDMKADGYSLDDKRNPIEDNDINDIIERFNNLDKEEERKRTEQSFFVPVEEIRDNGYDLSINKYKEIEYEEVHYDAPSVILDRVKSLEKEITQGLEELERMLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI28</accession>
    <name>A0A386PI28_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_10125</name>
        <name evidence="11" type="ORF">EI377_04925</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676604.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00354"/>
    <dbReference type="EnsemblBacteria" id="AYE34731">
        <property type="protein sequence ID" value="AYE34731"/>
        <property type="gene ID" value="CP523_10125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60132">
        <property type="protein sequence ID" value="QAS60132"/>
        <property type="gene ID" value="EI377_04925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="349" mass="38346" checksum="E1504056941EA84E" modified="2018-12-05" version="1">METRVAVIKDIDKDKKYIEEAAKIIKNSGVVAFPTETVYGLGANALNTDAVDKIFKAKGRPQDNPLIVHVASKDISDIVFDIPKVAQKLIDKFWPGPLTIILNKKSIIPDVTSAGLNTIGVRMPNSKIALKLIELSECPIAAPSANISGRPSPTEMERCVEDLSGKVDYILGGEKSDIGVESTIVDCTVEPPVVLRPGGITLEMLREFHEGIKLDPAIQGKPSKDLRPKAPGMKYRHYAPKANLKIIKGNNEKTIEKISEMVHNYIENHKRVAILATDENLSRFKSGEIISLGSELNLNEIARNIFETLRKCDDLGVDIILCQAFEEKEVGVAIMNRLNKAAGFDIIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI98</accession>
    <name>A0A386PI98_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07860</name>
        <name evidence="3" type="ORF">EI377_02550</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675987.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00675"/>
    <dbReference type="EnsemblBacteria" id="AYE35845">
        <property type="protein sequence ID" value="AYE35845"/>
        <property type="gene ID" value="CP523_07860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59743">
        <property type="protein sequence ID" value="QAS59743"/>
        <property type="gene ID" value="EI377_02550"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="172" mass="20215" checksum="B788230B5F23229F" modified="2018-12-05" version="1">MLFGEQIYLRDVVKEDIDILYDICVDVEVLKYNCGSVGIPSKDRIIERFHHLNRPNRKELSVVNKDSDVIGYVYYKENSYTIDTYSIGITIGKSYWGLGYGRDVVNQLCKYLFLKKKAHRIELEVVKDNERAIKCYKNCGFKEEGIRRSKYYLNGEYIDTVLMGMLKSEFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIB2</accession>
    <name>A0A386PIB2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ORF">CP523_09260</name>
        <name evidence="13" type="ORF">EI377_04005</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678314.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03046"/>
    <dbReference type="EnsemblBacteria" id="AYE34598">
        <property type="protein sequence ID" value="AYE34598"/>
        <property type="gene ID" value="CP523_09260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59998">
        <property type="protein sequence ID" value="QAS59998"/>
        <property type="gene ID" value="EI377_04005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="87"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="285" mass="31790" checksum="4AB56E0A2968D788" modified="2018-12-05" version="1">MNEIILLVVNSIKNISIYSVLDILVVAYIFYKGYVLIKETRAEQLLKGIILIIVLIPISYILKLDMLYFILNKTLTIGVLSVIIIFQPEIRRALEHIGRSAFEEFHNIQDQEKRNIAINEIVTAVANLAESKTGALIAIEQATGLGEVLNSGTILEARITSNLLENIFVVNTPLHDGATIIRKDKILAAGCVLPLTNNININKKLGTRHRAAIGLSETSDALVIIVSEETGVISLAINGRLTRNYDKEKLRIILLRIMENRESKRVKSAGEKVKTWIKGIKTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC3</accession>
    <name>A0A386PIC3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lytic transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09675</name>
        <name evidence="3" type="ORF">EI377_04455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02641"/>
    <dbReference type="EnsemblBacteria" id="AYE35853">
        <property type="protein sequence ID" value="AYE35853"/>
        <property type="gene ID" value="CP523_09675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62160">
        <property type="protein sequence ID" value="QAS62160"/>
        <property type="gene ID" value="EI377_04455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09675"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="237" mass="26822" checksum="E872EE159043D888" modified="2018-12-05" version="1">MSFNKEVLKKTIGDGPEFDLVYQALLDNMKDEAASEGNESNSSQDYLVKSTNAGVRLDKIPMRIKRENENIINNLYNKLDNEVSLQSLDNKVTSQDVDISNLDNGERINRAVDKYSQEFGVDKNLILAIIKQESNFDPNVESEAGAKGLMQLMDFNVEEYGVTDPFNIEENIRGGVNHIKEYLDMFDGNIEMALMAYNGGPGNMERRGVTSVNDIYKMPLETQAYVPKVMNYYRNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="CP523_07980"/>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="437" mass="47225" checksum="9A8AE3722BADC6FF" modified="2018-12-05" version="1">MKKRENFTSRAGFVLSCIGAAVGLGNIWMFPYRLGQNGGSVFLIPYFIFVLILGSTGLITEFAFGRAAQGGSLTGIKNSFRNKGLKGGVLVGAIPAIGLAGVFMFYNVVVGWIIKYFTLSVDGGINKIDISTFFDGFSGSPETIIWNFLAIAIALAIVCIGITNGIEKINKIIMPLLFVIFIILAIRSLTLPGAMEGVKYLLTPQWEYLFKINTWVMALGQAFFTVSLNGCGMVVYGSYMKRDMDIPRSAISTAIFDTISALLASFVIMPAVFAFGFDPAAGPPLLFITIPTIFKSMAGGQLLCILFFLSIIFAAISSSINMLEGPVEALMSQSKISRKKATIFIAMALFVLSIPLNVNMNLFNGFADLMTVILSPVGALIVFISFYFLNNKDIVLEEINTGASKCLGNKFILFAKYGFTITTILVIILGIIYGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG4</accession>
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        <lineage>
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                <person name="Seyboldt C."/>
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                <person name="Leendertz F.H."/>
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            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE35147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
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            <dbReference type="EMBL" id="QAS60550.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="790" mass="88568" checksum="213A6F421D972C50" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
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                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34911">
        <property type="protein sequence ID" value="AYE34911"/>
        <property type="gene ID" value="CP523_11090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60305">
        <property type="protein sequence ID" value="QAS60305"/>
        <property type="gene ID" value="EI377_05880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="351" mass="40232" checksum="D214D24CFC23B385" modified="2018-12-05" version="1">MRKSITKKSGIILLVILLFTTLVSCGRVDKETVISSDVSEDIKVEEKMEENKLKSTIEEGNKYLSEGKFTDAKVAYEKAISMAKDNKDLYLQIKNKYIEANRLDDAYYIIRLAINNNTDVDNMKQILNDIQSKFEIITFSPIVYQEDNYELPTKVSTLINNEEIPITINWNGALANTSTPGEFNFQGFNEQYGKTFNLNLTVKPNIFDKEIGSIKSIYKSNGKTYIDIDLAEFFIDKEALDAALADGIDLPTRDDGSPYVLNRYYIRNNSPSIKTYELSDNTSFTLCECDKIFFGYDREPGNLSNTEFPVTLEEFEYYINKESSSYFSRTTLCWINIKNGIVYSIDKQYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL0</accession>
    <name>A0A386PIL0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11190</name>
        <name evidence="3" type="ORF">EI377_05980</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00902"/>
    <dbReference type="EnsemblBacteria" id="AYE34931">
        <property type="protein sequence ID" value="AYE34931"/>
        <property type="gene ID" value="CP523_11190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60325">
        <property type="protein sequence ID" value="QAS60325"/>
        <property type="gene ID" value="EI377_05980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="496" mass="56744" checksum="DD6820C87BE1FFFB" modified="2018-12-05" version="1">MTFNKLSRKKTVKKLKNNSSLSNYIIFAIIVLLSSYLIYTLVLTPVIGKADNGDFGRMYNSLGIGPLGNSYDEIYTGYFQQTWKISSPGFFIPWCNDWVFGCWLLKIPSLFALMFGVKYFDIRAVGIFYSLIFLLGVYLILKYSKINSLGKLFGGIFILIFFTDSSYISYFNSFFGEATTISFLFLFIGSILNLIDKDNPKKLDLLFLFFASFGFLTSKTQQLPLLIFMILIYIALYKFYPTYRKLILSSSLIVITMCIITFFSIGTYTNRNNIYQAVFTGVLKGSETPKEDLIDLGLDPKFAPLANSGFYDKGLAFDPLGDEMMKDFYPNIGLSKILKFYAKHPNRAFEKFIASAENAYDFHKSSERDFNKGEYTTNKLINNFRVSLINKYPGILRNFTVFFTFSLIYLLVLIYHFFKFKNREYKILTLTLLFLLAAGASQLVLPVIGSGEADFGKHLFLINLAYDSLLCSCLIFLGVKAQNLFSKIYHNKKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ8</accession>
    <name>A0A386PIQ8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplD</name>
        <name evidence="8" type="ORF">CP523_08980</name>
        <name evidence="9" type="ORF">EI377_03725</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678352.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00236"/>
    <dbReference type="EnsemblBacteria" id="AYE34542">
        <property type="protein sequence ID" value="AYE34542"/>
        <property type="gene ID" value="CP523_08980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59942">
        <property type="protein sequence ID" value="QAS59942"/>
        <property type="gene ID" value="EI377_03725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="206" mass="22861" checksum="978CE4BDDF4B8134" modified="2018-12-05" version="1">MPTVGLFNQEGKQVGDIQLNDNVFGVEVNQDAMHQMVVALLANKRQGTQSAKTRAEVRGGGIKPWRQKGTGRARQGSIRAPQWIKGGIVFAPKPRDYRMSVPKSMRRVAMKSALTSKVQEGEMIVLENLTFEAPKTKNMVEVLKAFEAKKTLIVTAESNEAVYKSARNIAGVEVMPVNNINVYDLLKFQKLIITKDAVSKIEEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIV4</accession>
    <name>A0A386PIV4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">buk</name>
        <name evidence="10" type="ORF">CP523_09280</name>
        <name evidence="11" type="ORF">EI377_04025</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678306.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03042"/>
    <dbReference type="EnsemblBacteria" id="AYE34602">
        <property type="protein sequence ID" value="AYE34602"/>
        <property type="gene ID" value="CP523_09280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60002">
        <property type="protein sequence ID" value="QAS60002"/>
        <property type="gene ID" value="EI377_04025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="356" mass="38849" checksum="A03B3D4B5163D05F" modified="2018-12-05" version="1">MSYKLLIVNPGSTSTKIGVYNGEKEVLEETLRHSAEEIGKYATIYDQFKFRKDVILNVLKEKNFDIKTLDAVVGRGGMLKPMEGGTYKVNEAMLEDLKVGVQGEHASNLGGIISNEIGKELGIPAFIVDPVVVDELNDIARISGVPELPRISKFHALNQKAVAKRYGEEFGKGYENLNLIVVHLGGGASVGAHKNGKVIDVNNALDGDGPFSPERAGSVPVGDLIKMCYSGKYTEKEVFSKIVGKGGFVAYLGTNDLRDVLKLLEEGDKKAELVYDAFIYQVSKWIGEMSTVLCGKVDAILVTGGIAYSQKVIDDIKSRVEWISKIVAYPGEDELLALAQGAIRVLDEKEEAKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX8</accession>
    <name>A0A386PIX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PucR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10775</name>
        <name evidence="6" type="ORF">EI377_05560</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674094.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01347"/>
    <dbReference type="EnsemblBacteria" id="AYE34848">
        <property type="protein sequence ID" value="AYE34848"/>
        <property type="gene ID" value="CP523_10775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60242">
        <property type="protein sequence ID" value="QAS60242"/>
        <property type="gene ID" value="EI377_05560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF_2" evidence="4">
        <location>
            <begin position="152"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="3">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="403" mass="47253" checksum="B58299CE7014C9A4" modified="2018-12-05" version="1">MTLCCKDLFQLKYFSEAKLLAGKGGLNREISLPYVRNTESISNWLYGGELLFVTYEESKKDDNDLLLLFEECINKRLSGVVILIDNKNIDNIPNKIIEMSNKEKLPLFIMPWDIKLVDIIQEIFLKIEQNREESKNAKHFLESIIFSQNNFSDDINTLAEFYNIKIRPFHCISLFKIKKLNNNCYDTGNINRTIVNSLEETLNTEIYTLLPMEYADHLLLLIFSNSNDDMKKVVQAIEAVLNITRSKYPDIEINLSFSRIRKEYSEIKASYKEAFKALSIINIYSKDSNIIRYDDLGIIRLFMELTDTKEVEQYCYENIGPILEYDNKHGMNLIGTLKCYFQNNRHLIKTSQELFIHRNTLLYRLSTIKELLQKDLDDAIINLELFNSILIYEFINLRNEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ0</accession>
    <name>A0A386PIZ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA 2'-phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kptA</name>
        <name evidence="6" type="ORF">CP523_05645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR&gt;P). May function as an ADP-ribosylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35830">
        <property type="protein sequence ID" value="AYE35830"/>
        <property type="gene ID" value="CP523_05645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00299">
        <property type="entry name" value="KptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022928">
        <property type="entry name" value="RNA_2'-PTrans_KptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PTHR12684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="175" mass="20340" checksum="973FAF7296D47AEA" modified="2018-12-05" version="1">MNHINYLGLSKEISYALRHAPWEYELELDENGWVSAEQLLTALNESDKWENVTLEDLEHMIENSDKKRHELVEGRIRAIYGHSIPKKIVKESTEPPAILYHGTVRRFIKSIEDKGLLPKGRQYVHLSNDIKTALQVGKRHDNKPIILEISKKYINNLLNNINNAVKRRNEPAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ21</accession>
    <name>A0A386PJ21_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alanine:cation symporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Sodium:alanine symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_13980</name>
        <name evidence="11" type="ORF">EI377_08880</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00163"/>
    <dbReference type="EnsemblBacteria" id="AYE35447">
        <property type="protein sequence ID" value="AYE35447"/>
        <property type="gene ID" value="CP523_13980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60835">
        <property type="protein sequence ID" value="QAS60835"/>
        <property type="gene ID" value="EI377_08880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="475" mass="51288" checksum="76F4E522D131F00B" modified="2018-12-05" version="1">MELINKLILNINDFLWTYILIAMLIVSGIYFTFKTKFVQFTNIKEMFKLLGEGSSKEHEHSVSSFQAFCISTASRVGTGNLAGIATALAIGGPGAIFWMWLIALIGASSSFIESTLAQIYKVKDGNSFRGGPAYYMEKGLKKRWMGVLFAILITITFGLVFNSVQANTITLALNESFGFNRSVLGIILTLLTVIIIFGGVNRIANVSSILVPIMAVAYIAVALFIVVINFSELPGVLKMIFDNAFGINQAVGGSLGAALLQIIKKGNPVLLQGVKRGLFSNEAGMGSAPNAAATATVSHPVKQGLIQTLGVFTDTIIICSCTAFIILLSGVPLDGSVKGIQLTQMALTSQLGPFGGIFVSICILLFAFSSIVGNYYYGEANISFITDKKIYVLVYRLSVGLMVFFGSLVSMDIVWNLADVFMGLMAIINLIAILLLGKIAFKALADYNKQRKEGKDPIFKSSSIPELGDEVEEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ50</accession>
    <name>A0A386PJ50_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_09680</name>
        <name evidence="6" type="ORF">EI377_04460</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676717.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02642"/>
    <dbReference type="EnsemblBacteria" id="AYE34672">
        <property type="protein sequence ID" value="AYE34672"/>
        <property type="gene ID" value="CP523_09680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60072">
        <property type="protein sequence ID" value="QAS60072"/>
        <property type="gene ID" value="EI377_04460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="238" mass="27340" checksum="CC826BCD3C0E6A5A" modified="2018-12-05" version="1">MERLDKVLSNLGYGTRKEIKQAVRKGFIEVNGEIVKDNGMQIDPENDKIFVNGEEIFYRKYIYLMMNKPAGVISATHDGRDETVVDLLEIEHQVFNPFPVGRLDKDTVGLLLLTNDGELNHRLISPKWKVDKVYFAKIDKKVTEEDIHKFNKGITLDDGYVCKEAKLEILNSSEDGSEILVTIQEGKYHQVKRMFEAVGKSVVYLKRIEFGTLPLDEDLEEGEYRELTHEELSVLKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ57</accession>
    <name>A0A386PJ57_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">btuC</name>
        <name evidence="8" type="ORF">CP523_12985</name>
        <name evidence="9" type="ORF">EI377_07860</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677806.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02537"/>
    <dbReference type="EnsemblBacteria" id="AYE35264">
        <property type="protein sequence ID" value="AYE35264"/>
        <property type="gene ID" value="CP523_12985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60659">
        <property type="protein sequence ID" value="QAS60659"/>
        <property type="gene ID" value="EI377_07860"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="342" mass="36474" checksum="3A90C5D270516B15" modified="2018-12-05" version="1">MNINKKNNTLMILSIPVVFLIICIGTSIGSSNISIMDIISIIGNKVFNIPLSSGIDPKDVSIIWSIRLPRVLLAFVVGGALAASGAVVQSVLKNPLASPYTLGVSSGASLGVGLIIVLGVSIPFLGNFTLPLVGFLCSLLTMIIVLTFASKVDKGLSNNTIILSGMVFSLFFNALLTTITALFTEKIEAITMWQMGSFSMRGWSYLKGGFPFFILGIIGIMMYCKEMDVLTFGEEQAKSIGVEAEKVKKRLFLFTAVLTGAAVAISGTIGFVDLIAPHMVRKIFGSKHSNVIPMSVVFGGGLMVITDLVARTIIIPSELPVGAITAIIGAPFFAYLYFKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ86</accession>
    <name>A0A386PJ86_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS ascorbate transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11450</name>
        <name evidence="9" type="ORF">EI377_06265</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673290.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02847"/>
    <dbReference type="EnsemblBacteria" id="AYE34978">
        <property type="protein sequence ID" value="AYE34978"/>
        <property type="gene ID" value="CP523_11450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60371">
        <property type="protein sequence ID" value="QAS60371"/>
        <property type="gene ID" value="EI377_06265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11450"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="451" mass="47399" checksum="894B99F99B723C80" modified="2018-12-05" version="1">MNGILKVFVDFLSEPSVLIGIIVLIGLILQKKSTDVIIKAVLKAMVGFVVISAAAGVIVSSLQPFGVMFEHGFNISGVIPNNEAVVAMAMDKFGTNTALIMTFGMIVNIIIARITKYKYIFLTGHHTLFISCMIAVILASAGMGGVHLIFTGSLALGIIMVIFPAMLQPFMKKITGNNSVALGHFSSTGYVISAIIGKLVGKNSKSTEEMKVPKSLSFLRDSVVSISITMLILYVGVAIVAGPQFVESELSGGKNFIVYAMIQALTFAAGFILIQNGVRLVLNEIVPAFKGISNKLVPNSKPALDCPIVFPYAQNAVLIGFICSFLGGIVSMIGLSILGLVIIIPGVVPHFFTGATAAVFGNATGGRRGAIIGSFVNGIIISLLPVALLPVLGNLGFANSTFSDADFGVVGIFLGKLQQYIGGIGLTITLIGIVVIMVILTVIDNKKEVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ98</accession>
    <name>A0A386PJ98_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679052.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35314">
        <property type="protein sequence ID" value="AYE35314"/>
        <property type="gene ID" value="CP523_13250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="117" mass="13494" checksum="892BBAD250E891B7" modified="2018-12-05" version="1">MKINGVELEDLDIYDLEVAERYEKALENLTGIEEKVANKKNSESIRIMCNAVFNIFNTMFGEGTDKKVFGKKVNLLTCMSAIDELVEKTNEKKKEINKFTSKYSPNRAQKRVQKHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL8</accession>
    <name>A0A386PJL8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lytic transglycosylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13715</name>
        <name evidence="4" type="ORF">EI377_08605</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677162.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02079"/>
    <dbReference type="EnsemblBacteria" id="AYE35401">
        <property type="protein sequence ID" value="AYE35401"/>
        <property type="gene ID" value="CP523_13715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60789">
        <property type="protein sequence ID" value="QAS60789"/>
        <property type="gene ID" value="EI377_08605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="36"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="181" mass="21301" checksum="1EB372FC9DED1F8B" modified="2018-12-05" version="1">MKFKRIIIFLLTIVIIYIAVIFSMKQYIFPYKYTEYVDKYSKEYDLDPLLVMAVIKAESDFDEKAVSNRGAKGLMQVMDNTGEWACKEIGINYFMPSMLMDPEFNIRIGCWYLNNLRNEFGDLDLIIAAYNGGSGNVNKWLNDDEYSKDGETLTYIPFKETKKYVDKVKINYSVYKYLYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR0</accession>
    <name>A0A386PJR0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4363 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF4363 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10815</name>
        <name evidence="2" type="ORF">EI377_05600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677603.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02497"/>
    <dbReference type="EnsemblBacteria" id="AYE34856">
        <property type="protein sequence ID" value="AYE34856"/>
        <property type="gene ID" value="CP523_10815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60250">
        <property type="protein sequence ID" value="QAS60250"/>
        <property type="gene ID" value="EI377_05600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025373">
        <property type="entry name" value="DUF4363"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14276">
        <property type="entry name" value="DUF4363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="126" mass="14460" checksum="74099FDE2F02749E" modified="2018-12-05" version="1">MKNTIISIMLFLLLIGALFYLDTDFISLCDEIIIKCEKIEDSLDNNDKSFAYDQAVELLGLIKEKSTIPAIYLNHVDYDTLMNESLKLSLYIKGNDRAESLSSVHLLRYSAEHLKDLQKPNFKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR7</accession>
    <name>A0A386PJR7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12630</name>
        <name evidence="4" type="ORF">EI377_07535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675224.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01985"/>
    <dbReference type="EnsemblBacteria" id="AYE35198">
        <property type="protein sequence ID" value="AYE35198"/>
        <property type="gene ID" value="CP523_12630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60601">
        <property type="protein sequence ID" value="QAS60601"/>
        <property type="gene ID" value="EI377_07535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="95" mass="11119" checksum="09D7C734023464A7" modified="2018-12-05" version="1">MFGIEERVYNNLLKYFRESSYIKRVLIFGSRAKGSYKYNSDIDLGILCEKSYRGIIVEEIDEIIGVYSCDIVFLDNMNEEIKLQIDRDGIEIYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU4</accession>
    <name>A0A386PJU4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NADH-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14260</name>
        <name evidence="5" type="ORF">EI377_09170</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676760.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02441"/>
    <dbReference type="EnsemblBacteria" id="AYE35501">
        <property type="protein sequence ID" value="AYE35501"/>
        <property type="gene ID" value="CP523_14260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60887">
        <property type="protein sequence ID" value="QAS60887"/>
        <property type="gene ID" value="EI377_09170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="10"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="388" mass="43462" checksum="F66B1FAEB55FCED6" modified="2018-12-05" version="1">MKNFNYKNGTKLIFGKDTELKIGKEIKKYSNKILLHYGGGSIKTTGLYEKIVNSLNEEGIEFIELSGVKPNPRVSLVRKGINICRDNNLDFILAVGGGSVIDSAKAIAAGVNYSKDVWDLFMDTPINHKCLNLATILTIPAAGSETSSGTVITNEEGWYKKSTGHPTLRPIFSIMNPELTFTLSKYQTACGIADMLAHVMERYFTNEPNVDLTDRLCEATMKSIIDNGLRVINNLNDYNSRAEIMLSGMIAHNDSLSMGRIGDWASHDIEHELSGIYDIPHGAGLAIIFPAWMKYVYKHDINRFAQFANRVFNIDINLNNPEETVLLGIKKLEDFFKELGLKTTLKEININNEHFSEMAKKLVELNGHVGNFVEIKYEDAIEIYKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJV6</accession>
    <name>A0A386PJV6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sporulation protein YtxC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ytxC</name>
        <name evidence="1" type="ORF">CP523_14565</name>
        <name evidence="2" type="ORF">EI377_09535</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678672.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00199"/>
    <dbReference type="EnsemblBacteria" id="AYE35554">
        <property type="protein sequence ID" value="AYE35554"/>
        <property type="gene ID" value="CP523_14565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60940">
        <property type="protein sequence ID" value="QAS60940"/>
        <property type="gene ID" value="EI377_09535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014199">
        <property type="entry name" value="Spore_YtxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08812">
        <property type="entry name" value="YtxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02834">
        <property type="entry name" value="spo_ytxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="296" mass="34879" checksum="1100E9370978027E" modified="2018-12-05" version="1">MIVLKLVYNDDLDFIREIQDLRTILKKKDVTIGVVESVELNTHIVKVLCDDDDYNEKIKNIINLYISNILYKIVIEKYKDKEMFDFLIDNYFFLKQEEVLEVEDQIMKVLLCEEAVNDENLVYCMNKMNSVIEKIKECLEENFEINIDGFITFRMKELRGDIENIIDKVIENYMVEKEYKEFVKLLKYFVEIQESKLEEVDIFIKDGGGYLITDHLGNNIFQEFLKELAECKIDNDAKMEDVIISGLITNAPKKIIIHGKENCINNEFLDTIVNVFTDRVKYCEGCNLCSIEKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJW2</accession>
    <name>A0A386PJW2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12900</name>
        <name evidence="7" type="ORF">EI377_07780</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35248">
        <property type="protein sequence ID" value="AYE35248"/>
        <property type="gene ID" value="CP523_12900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60643">
        <property type="protein sequence ID" value="QAS60643"/>
        <property type="gene ID" value="EI377_07780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="461" mass="49991" checksum="0A7B3EA877721D0B" modified="2018-12-05" version="1">MIRRKKMNEKRLNTLANEKVSKAIFKMSIPMVMGMMVQVLYNLVDTYFIGRLNDTNQLAAANISFPIFIVFMALAGVMGIGASSYISRALGKNEKGEADKTATIALVLCLGLGLIITILGLIFIKSIVIVLGSSNETFIYTYRYVAIMLIGGVFIMGNFALGQLLRAEGGAMQSMMGLLIGTVANIVLDPIFIFTFNMQITGAALATIVGNFLGFAYYAYVFLSNKTVTKINFKLFSFDKKIIGEILKIGLPASLNQMLMSVAITVSNNIAVYYGAVVVAGMGVASKIMTIGTFIFMGFSSGCQPLVGYNYGAKNVERVKEVIKKGIIITSTIGVVLAIIFGVFANNLINIFINDGEVVKYGTIILRALILSLPFVGAQMVSTTSVQSMGKALPALILSISRQGILYIPLILILNLVGGFTGFIYAQPITDLIMLILCIIVLLIILNRDAIMLVREKEIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK11</accession>
    <name>A0A386PK11_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11570</name>
        <name evidence="3" type="ORF">EI377_06385</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673342.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35002">
        <property type="protein sequence ID" value="AYE35002"/>
        <property type="gene ID" value="CP523_11570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60395">
        <property type="protein sequence ID" value="QAS60395"/>
        <property type="gene ID" value="EI377_06385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="122" mass="14852" checksum="107D94E65DFAE8B9" modified="2018-12-05" version="1">MYETRIGFQLYVVGSKSWSFYDDDWIDNKDYIPKCRKSNIRLINRIKSYYDKDEYIKMFFSIIVIITYYILKYVKENKYRVLKNKNINISLGLDDGDIINLYRIYNSKIEVYKKSISLSIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK15</accession>
    <name>A0A386PK15_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12600</name>
        <name evidence="3" type="ORF">EI377_07505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35867">
        <property type="protein sequence ID" value="AYE35867"/>
        <property type="gene ID" value="CP523_12600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62176">
        <property type="protein sequence ID" value="QAS62176"/>
        <property type="gene ID" value="EI377_07505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="174" mass="17626" checksum="D17A073874EC73A2" modified="2018-12-05" version="1">MGGMPGGMPGGGMGMGGNPLMSMLMGGNPMGGMGNMGGNPMANMGGMGNNPLGMMMSMLMGGNPMGGMGNMGGNPMGNQMGNNPLGMLFNGLGGNGMSNQGNNQGNRNNFDMSQVLNMLMGGNNGGQMGNPMGNQMGSNQMGNNPLGMLFNGMGGMNNNSKPNTMSNSRSRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK59</accession>
    <name>A0A386PK59_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1232 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_11640</name>
        <name evidence="7" type="ORF">EI377_06455</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AYE35016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02886"/>
    <dbReference type="EnsemblBacteria" id="AYE35016">
        <property type="protein sequence ID" value="AYE35016"/>
        <property type="gene ID" value="CP523_11640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60409">
        <property type="protein sequence ID" value="QAS60409"/>
        <property type="gene ID" value="EI377_06455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="DUF1232" evidence="5">
        <location>
            <begin position="225"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
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    </evidence>
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            <dbReference type="EMBL" id="AYE35016.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS60409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="318" mass="35978" checksum="ED3468B99C1BA49F" modified="2018-12-05" version="1">MNISDVKVGLTGEDLLSIANEFLNIDGLEISEINLKDEINITGSFNKGFKIDFIAGIKLVRIENGIIHAELSSFKLLKIGIVSLIRKLALKYAIKAFEDKGIHYEKGKIVINIKKILKDVPYVDFNIKDIYIYRSILNVELKDINISIKGNLIKGIEDPKEEDMEQDTALMVINKVKDNYSLGRECTLDKLPDKVKKISDYLFIIPDMVALIYRLLKDKRVAIKTKLVISAAVAYIALPTDIIPDNIPFIGKIDELAVTFFALDRIISDVPVYIILENWEGKNDIILVIKNMIEYVTNFTGAKNVEKLYSLLNELISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK63</accession>
    <name>A0A386PK63_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13590</name>
        <name evidence="3" type="ORF">EI377_08485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Eubacteriales</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="QAS60768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1504.GCA_900092375_00088"/>
    <dbReference type="EnsemblBacteria" id="AYE35378">
        <property type="protein sequence ID" value="AYE35378"/>
        <property type="gene ID" value="CP523_13590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60768">
        <property type="protein sequence ID" value="QAS60768"/>
        <property type="gene ID" value="EI377_08485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13590"/>
    <dbReference type="Proteomes" id="UP000280586">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="201"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="361"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="449"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="515"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="551" mass="63335" checksum="75BA10B01FC28CD7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKJ2</accession>
    <name>A0A386PKJ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytidine deaminase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">dCMP deaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_01840</name>
        <name evidence="9" type="ORF">EI377_12360</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677288.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02383"/>
    <dbReference type="EnsemblBacteria" id="AYE35794">
        <property type="protein sequence ID" value="AYE35794"/>
        <property type="gene ID" value="CP523_01840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62214">
        <property type="protein sequence ID" value="QAS62214"/>
        <property type="gene ID" value="EI377_12360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS62214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18188" checksum="2104838A7A96994C" modified="2018-12-05" version="1">MKRKDYISWDEYFMGVAVLAGKRSKDPATQVGACIVDCENKILSQGYNGLPVGCSDDEFPWDREGELLETKYPYVVHAELNAILNARGSNLYGAKIYVALFPCNECAKAIIQSGIKEVIYLSDKYSDTDIVKASKKLLNSAGIKLTKLEAKNKNINISLDLNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM8</accession>
    <name>A0A386PKM8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35322">
        <property type="protein sequence ID" value="AYE35322"/>
        <property type="gene ID" value="CP523_13295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1210" mass="137229" checksum="09D980AA695F4CDD" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKP9</accession>
    <name>A0A386PKP9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ORF">CP523_14525</name>
        <name evidence="15" type="ORF">EI377_09495</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678680.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00207"/>
    <dbReference type="EnsemblBacteria" id="AYE35548">
        <property type="protein sequence ID" value="AYE35548"/>
        <property type="gene ID" value="CP523_14525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60934">
        <property type="protein sequence ID" value="QAS60934"/>
        <property type="gene ID" value="EI377_09495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14525"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="38"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE35548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS60934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="329" mass="36589" checksum="F54A8D62F481A0E5" modified="2018-12-05" version="1">MYNVAIVGATGNVGRKFLEILEERNFPIKNLYLFASKKSAGSTLKFKDKNLLVEETCDENIKNKKVDFALFSAGGSVSLEFAPKFASYGAIVIDNSSAWRMDNDVPLVVPEVNPEDVKWHKGIIANPNCSTIQAMVPLKVLLDNYGIKRIIYSTYQAVSGAGVQGIADLQDGLKGTPPKKFPYTIAGNCLPHIDVFLDNGYTKEEIKMIEETRKIFHNPNLKITATTVRVPVLNSHSESINIELDKEYQLKDVFKLFKNTKGLTVYDDAKNLKYPTPIMVSGKDEVFVGRIRRDFSVNNGINLWVVADNIRKGAALNAVQIAELLIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKS8</accession>
    <name>A0A386PKS8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_10980</name>
        <name evidence="10" type="ORF">EI377_05775</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677665.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02530"/>
    <dbReference type="EnsemblBacteria" id="AYE34889">
        <property type="protein sequence ID" value="AYE34889"/>
        <property type="gene ID" value="CP523_10980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60284">
        <property type="protein sequence ID" value="QAS60284"/>
        <property type="gene ID" value="EI377_05775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="212" mass="24674" checksum="13559A43697394FF" modified="2018-12-05" version="1">MINVNGQERKQSVLYPIIKRVTDIIISLSALILLSPLLLIVSFLILIDSKGPIIFKQDRVGKNGKIFKMYKFRSMVVNAEELKKKLENKNEMTGPMFKIKEDPRITKIGKFIRKTSIDELPQLINIIKGEMSLVGPRPSLPSEVEKFEPWMMERLDVLPGLTCYWQVMGRNSIGFKEWMELDIKYVRERNCWIDIKLIFKTFFVIFGDENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKT0</accession>
    <name>A0A386PKT0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13670</name>
        <name evidence="4" type="ORF">EI377_08560</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02088"/>
    <dbReference type="EnsemblBacteria" id="AYE35392">
        <property type="protein sequence ID" value="AYE35392"/>
        <property type="gene ID" value="CP523_13670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60781">
        <property type="protein sequence ID" value="QAS60781"/>
        <property type="gene ID" value="EI377_08560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="33837" checksum="C6314B8A4AD8432C" modified="2018-12-05" version="1">MNFRKLKIFYETATCLNMTKVAKNMYISQPSISQSINELEIELEVKLFDRIGKKIYLTHEGEVFLNYTRRILNLYDEGTKTLKDFNSNIKGKITIGASTTIGIYILPEIIKEFSSEFKDIEISLIIENTEHIEKLILENKIDFAYIEGSIESDEISAEKIWEDELVFICGKNHKFKGRKVVLGKELADEKFIMREKGSGTRENVENFLKNKRVPCKIFLELGNTEAIKRTVEANLGIGGISLITIQEKLKTGDLNAFRLKEGVIKRDLLFIMHKDKFISNNMKKFIEFAGESNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL12</accession>
    <name>A0A386PL12_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13690</name>
        <name evidence="3" type="ORF">EI377_08580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677174.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02084"/>
    <dbReference type="EnsemblBacteria" id="AYE35396">
        <property type="protein sequence ID" value="AYE35396"/>
        <property type="gene ID" value="CP523_13690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60785">
        <property type="protein sequence ID" value="QAS60785"/>
        <property type="gene ID" value="EI377_08580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="300" mass="34734" checksum="4138CEC487FDE8F8" modified="2018-12-05" version="1">MFNILVLGDTLFVCDALVKHLINKGHEVDLLTSENITLNYMGYRTHIICNRRSEEDLRKVLKNKHYDIVFDISAYNKDDIEILFNCLDSKSLKKYIFFSSAAVYIPSKEITFENSPKGENSILGEYGLNKLNAEEYINDLINNNSVKAIIFRTSYIYGKGNNLYRENYFFDKIMNNEIIYIPNNDVKIQFIHIDDLVKICECALYNDNLNRAYNVTSPNQISWRELVETCGNILKIKPTIKEVDINSPLLRDFPFKNVDLNLNITDLRENGFHLPVIYLDQGLKLTFNSDLKNKKTNGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL86</accession>
    <name>A0A386PL86_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division protein FtsQ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">FtsQ-type POTRA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_14885</name>
        <name evidence="10" type="ORF">EI377_09840</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676087.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01306"/>
    <dbReference type="EnsemblBacteria" id="AYE35612">
        <property type="protein sequence ID" value="AYE35612"/>
        <property type="gene ID" value="CP523_14885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60999">
        <property type="protein sequence ID" value="QAS60999"/>
        <property type="gene ID" value="EI377_09840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="28196" checksum="1CA26AEBE84129D7" modified="2018-12-05" version="1">MNKKAQEFIRKKKKRKAVKRFALAIFIIIVAMIIFAYKSSIFNIKSISVEGIVTLNKDELEESLSTFKGKNIFTVNYNEIKDEVKKNPYVSDVVVKKKGINALNIIIKENKIAFYIEEGDTKKIVNNNLTLVEKVSSVEGRNLVKLIGVKDNGKDIGETIVENKHLNKILSDFYPIIENMPPEHKIESLNVEDITNIKINIKDVKVFLGNTDKLVEKMNLVLNAIDQGVITKGYIDLSFDGPPVIKQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLG5</accession>
    <name>A0A386PLG5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15485</name>
        <name evidence="3" type="ORF">EI377_10190</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678719.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35722">
        <property type="protein sequence ID" value="AYE35722"/>
        <property type="gene ID" value="CP523_15485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61061">
        <property type="protein sequence ID" value="QAS61061"/>
        <property type="gene ID" value="EI377_10190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362734" evidence="1">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="13370" checksum="90E6E000F915F73F" modified="2018-12-05" version="1">MKKKFFVLSLVSLLFYSFLSLPTLAVNKFNNLNTVPVSDVYKKGFYNFNITYTSCEAIAKLVSTDKNAVIMVVNSDNTLRLFKKCTPNDPTILIGNLTKNDTVIIIGEGEFSIKFIKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLU6</accession>
    <name>A0A386PLU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1294 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14250</name>
        <name evidence="3" type="ORF">EI377_09155</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678485.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00272"/>
    <dbReference type="EnsemblBacteria" id="AYE35499">
        <property type="protein sequence ID" value="AYE35499"/>
        <property type="gene ID" value="CP523_14250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60885">
        <property type="protein sequence ID" value="QAS60885"/>
        <property type="gene ID" value="EI377_09155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010718">
        <property type="entry name" value="DUF1294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06961">
        <property type="entry name" value="DUF1294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="88" mass="10505" checksum="A34ADD4BFF59A584" modified="2018-12-05" version="1">MYNILKIYFITINLFAFIIMFIDKQKAIKKQWRISENNLVLIAILGGSVGEYISMHIFRHKTHHIKFTFGIPFIIFLQLLIVFLYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAQ4</accession>
    <name>A0A386PAQ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00275</name>
        <name evidence="4" type="ORF">EI377_10615</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677361.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01178"/>
    <dbReference type="EnsemblBacteria" id="AYE32995">
        <property type="protein sequence ID" value="AYE32995"/>
        <property type="gene ID" value="CP523_00275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61138">
        <property type="protein sequence ID" value="QAS61138"/>
        <property type="gene ID" value="EI377_10615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="95"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="327" mass="37064" checksum="E0A41A5CE41CFB36" modified="2018-12-05" version="1">MRKFLKTLLVVFFICVFGIGIFTYVFRNRINLYLNIAKNYLQIEEDMKSIEDLTCYTPLNSMDYKDIVYKNQNGVELTLDLFGPTKKLNGGSPVVLFVHGGSWIYGDKTIPKSISPLLESFRESGYTVISTSYEFLKEDINMDKPISDVKDTIRWVYKNKDIYNFNTDEIGILGFSAGAHLSLISAYSNKDEFIGDINLKDYPSNVKYVIDIFGPTDLSTLNINNANTTIASELSELPNLNELEKKYSPINYVKEGVPETLIIHSKTDKLVPYENSTLLYNRLLKASVETKLVSLETSNHDLSNINVKELAPVALEVLKFVIKNSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBA0</accession>
    <name>A0A386PBA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Iron ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00425</name>
        <name evidence="8" type="ORF">EI377_10915</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00596"/>
    <dbReference type="EnsemblBacteria" id="AYE33020">
        <property type="protein sequence ID" value="AYE33020"/>
        <property type="gene ID" value="CP523_00425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61189">
        <property type="protein sequence ID" value="QAS61189"/>
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            <begin position="14"/>
            <end position="33"/>
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            <end position="87"/>
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    <sequence length="554" mass="62553" checksum="61A01DCCF1C9BF8B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000288332"/>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
            </authorList>
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        </source>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="AYE33343.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS61513.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="82" mass="9502" checksum="851283D0F491A62A" modified="2018-12-05" version="1">MGNNKYYHKKKGNDWGKFFQKTIRDFSDNVSKNIGNAFNCRNCCIQARLCIFGLIILTLLFSGIGFYSWLILAMLLIILQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
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    </protein>
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        <name evidence="2" type="ORF">EI377_12665</name>
    </gene>
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                <person name="Leendertz F.H."/>
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                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="CP523_02145"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="TrmK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04816">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="230" mass="26244" checksum="019629BA174EC5AE" modified="2018-12-05" version="1">MELSKRLNFIVEKVEKVIALADVGTDHGYIPLYALKNNICSEAIASDINKEPLDKARLNAILEGVGDELEFRLGNGLSVLKENEVQAVIIAGMGGNLIRDILEADTNIVNELEYLILQPAQNPEVLREYLYTNDYEIIDEDLCLDDGKYYELFKVRRKIGENTVLDSIYYEISPKLLMEKHPLMKEYINSKLDKYNKILSLITDETESATLRKEELLEKISILSNIVNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC71</accession>
    <name>A0A386PC71_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03250</name>
        <name evidence="2" type="ORF">EI377_13765</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677234.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33553">
        <property type="protein sequence ID" value="AYE33553"/>
        <property type="gene ID" value="CP523_03250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61716">
        <property type="protein sequence ID" value="QAS61716"/>
        <property type="gene ID" value="EI377_13765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="20547" checksum="EDBC1D48171DBA53" modified="2018-12-05" version="1">MRKRIVLLGAIDDFMVYFSKYLILNDTELYIIIRKEQTKKVLDELGNNITIIRYDGNTEHLKLFFKSIDADIVYNLSYFCKDRCNIKEFIDKNYTFITDILEGLKSSPRTRFINLKEKYKLDDENEPLEVNSAILKSMEIIIKYYTKKCNINIVELEKFNDPKIDMENILSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC99</accession>
    <name>A0A386PC99_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679102.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33575">
        <property type="protein sequence ID" value="AYE33575"/>
        <property type="gene ID" value="CP523_03380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="444" mass="49425" checksum="D2CFEB0541F5983C" modified="2018-12-05" version="1">MKEKKENINDNLTLRKKFIKYLLPSVAAMWVFSLYTMIDGIFVSRGVGPVALAAVNISMPFVNFIFALSMLFSTGVSTVIAIYLGQKKLDKAREAFSFNVLCIIVVSISITIISLINIDKITLFLGATDATFQLVKDYLKIIMIFNAFFIISYCLEVLSKTDGFPHLSIIGMIISAVTNIVLDFIFVILLGFGIKGAAFATIISQGVSCLFFLIHFLSSRGKLKFVKFKINFEMLKRILYIGFPDAITELTSGVVILLFNQTILKYIGEDGIITYSIISYVNTLVIMTMIAITQGMQPLSSYHYGKNENNVVKKLLKMSIKTIAFSSIFIFMLCIVFASPIVSIFLKGQSPELFAYSVSSFRIFSITFLVLGFNVLTSGYFASIEKTFDATIISLSRGLVLITIVLIAMTSLFGEKGIWISTLISELLCLIISITLLYKNKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCF5</accession>
    <name>A0A386PCF5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">PEP phosphonomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03705</name>
        <name evidence="2" type="ORF">EI377_14235</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677691.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02204"/>
    <dbReference type="EnsemblBacteria" id="AYE33635">
        <property type="protein sequence ID" value="AYE33635"/>
        <property type="gene ID" value="CP523_03705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61799">
        <property type="protein sequence ID" value="QAS61799"/>
        <property type="gene ID" value="EI377_14235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="297" mass="32117" checksum="9B2244F90E09DC6C" modified="2018-12-05" version="1">MKRLLSCYASDIKNMSSKDLKQAILASEGRIILGETVVTSAPLLEGVTNAEVMCAFGADMVLLNEFDVFEKKINGMKYEDNPIKKIKELVGRPVGINLEPVDYDASLLEEKINLSSGRLATVNTFCEAENLGVDFICLTGNPATGVSNESINNSIEIAKKHYSGLIFAGKMHGAGVSEKLLDEKIILSFIENGADGILIPAASTVPGVNETLLTDIINKIKEKNALVMCAIGTSQESSDEETIKLIGLSNKRVGADIHHIGDGGYGRMPIPENIMALSIAVRGKRHTYFKMTQSVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCG8</accession>
    <name>A0A386PCG8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03805</name>
        <name evidence="4" type="ORF">EI377_14340</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675475.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01533"/>
    <dbReference type="EnsemblBacteria" id="AYE33653">
        <property type="protein sequence ID" value="AYE33653"/>
        <property type="gene ID" value="CP523_03805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61815">
        <property type="protein sequence ID" value="QAS61815"/>
        <property type="gene ID" value="EI377_14340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018476">
        <property type="entry name" value="GlyceroP-diester-Pdiesterase_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10110">
        <property type="entry name" value="GPDPase_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="366"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="624" mass="71145" checksum="4D2618B330902BC7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCI9</accession>
    <name>A0A386PCI9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_00500</name>
        <name evidence="7" type="ORF">EI377_10990</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676315.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00629"/>
    <dbReference type="EnsemblBacteria" id="AYE33034">
        <property type="protein sequence ID" value="AYE33034"/>
        <property type="gene ID" value="CP523_00500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61203">
        <property type="protein sequence ID" value="QAS61203"/>
        <property type="gene ID" value="EI377_10990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="102"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="567" mass="63078" checksum="2AE794DAF452A716" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCJ8</accession>
    <name>A0A386PCJ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00550</name>
        <name evidence="2" type="ORF">EI377_11040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00639"/>
    <dbReference type="EnsemblBacteria" id="AYE33044">
        <property type="protein sequence ID" value="AYE33044"/>
        <property type="gene ID" value="CP523_00550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61213">
        <property type="protein sequence ID" value="QAS61213"/>
        <property type="gene ID" value="EI377_11040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="422" mass="48537" checksum="691C21975C8E47B3" modified="2018-12-05" version="1">MILDDDNILGKTIIKSIGGDVKGSKKEDIVYLVGEKDIMLKKAYYKNLEIIVLDGGTGKYTVIKLENNHGYNPYIQLDNFSGDSNNEILFVSDMGKSDGEINVEIYGFIGDKEIQLFSGKQFYTSSNYEVIYNDCYKVTILNYENNKKYILDISEKNKVYLDELYLNDKLKKQRKGKVSPINNIYTLKSNGNKAEILIIQNIIGLNDEDKLGVMLTRLKYTGGESFKNINTFVAEKGVPIEPNIEYRHIKEEIEINNLSIDFTSVDFFESERNRNYKIERCLEKEYNLIPGVDKFSYYYNKIDLNDDNRSEVIIYLEGPEFCEKNGGSVIVLSDFNEEYRVISKIKNVQTPIIISNESTNGYKNIIVKTKEKNKISFRILKFNGNSYPANPTDGYRFKKGSKIKGISLISDDLFYTTGIEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCR8</accession>
    <name>A0A386PCR8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04340</name>
        <name evidence="8" type="ORF">EI377_14875</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00410"/>
    <dbReference type="EnsemblBacteria" id="AYE33755">
        <property type="protein sequence ID" value="AYE33755"/>
        <property type="gene ID" value="CP523_04340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61912">
        <property type="protein sequence ID" value="QAS61912"/>
        <property type="gene ID" value="EI377_14875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="6">
        <location>
            <begin position="26"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="312" mass="36583" checksum="72EA52EECECA8F34" modified="2018-12-05" version="1">MEELFRHIEIGGVEQYILVRGNKDKPILLFIHGGPGTTNSGYIYKYQQSLENEFLVVNWDQRGAGKSFNNMLDFDDVSLEIIVDDAVELIKILMKEYSKDSIYLVGHSFGALVGVKVAEKEPNLVKAYLSISQVVNIEKEDKICYEQLLKLSKKMLRFRDLDKLKSIGKPPYNRENSVNVFNKYVSKYKMNINSMSYFSFMIKSFSFKYYNLYDWINFLRGIGFSKKAIYKEIEKIDLLKELKSIKVPVYFFVGFNDYITPLNVIGEFYDSLEAPEKKIYIFKNSSHLPHIEEEHKFFTICKSIKDKYEKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCY5</accession>
    <name>A0A386PCY5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">CP523_04830</name>
        <name evidence="11" type="ORF">EI377_15340</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675776.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01708"/>
    <dbReference type="EnsemblBacteria" id="AYE33845">
        <property type="protein sequence ID" value="AYE33845"/>
        <property type="gene ID" value="CP523_04830"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61991">
        <property type="protein sequence ID" value="QAS61991"/>
        <property type="gene ID" value="EI377_15340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04830"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="198" mass="22983" checksum="F9A9C9D8466C4125" modified="2018-12-05" version="1">MAKDRRPRFKMCRRLGLNVVGHPKAMDRAIKGTSRADKKLSDYGVRLLEKQRLRAYYGVLEKQFEKYVYDAFNEKGVTTGEALLIRLESRLDNMVYRMGFANSIRAARQMVTHGHLLVNGKKIDIPSYKLVPGDEISLREKSRKIPNFVEAAQTNKSNILPYINKDLDNFKGSYTRLPQREEIPIQINENLIVEFYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD67</accession>
    <name>A0A386PD67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05310</name>
        <name evidence="6" type="ORF">EI377_15870</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01850"/>
    <dbReference type="EnsemblBacteria" id="AYE33935">
        <property type="protein sequence ID" value="AYE33935"/>
        <property type="gene ID" value="CP523_05310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62086">
        <property type="protein sequence ID" value="QAS62086"/>
        <property type="gene ID" value="EI377_15870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362729" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="381"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="474"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="4">
        <location>
            <begin position="823"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1694" mass="189662" checksum="F954678C449A21B5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDG0</accession>
    <name>A0A386PDG0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00535</name>
        <name evidence="3" type="ORF">EI377_11025</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676327.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33041">
        <property type="protein sequence ID" value="AYE33041"/>
        <property type="gene ID" value="CP523_00535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61210">
        <property type="protein sequence ID" value="QAS61210"/>
        <property type="gene ID" value="EI377_11025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="336" mass="40109" checksum="F8D5F7FAA721206B" modified="2018-12-05" version="1">MFYLIMFLKVIILEYLLIFFHEIVHFITSLILGFKCTFYYVIPFTLYKKDNKLKFKLNEGFENVSTSRMHFKSVKITSDKEYNLLIKKLQILLWIGPIFDFTIFVILFSIGLCIPKYFFLTLTSLFHFTISTLNFFNSDGKYAIGSKEDYRIAFNLVRDITLCGSGNIDYDTKKFMTNKHLQISQSISLSEFDVHNLWNFLNNIYFYTNSLLSYINKDLLFLDDSTESFLDSLIDDFDKIKSLDYRQTKKTSISIILYFIYTKIKYKNFIPEKNILDKVYIGCNSEYYRKLIRYYFYGEYMYKNYLLNEKNMTDINLNCDGYNKLLITVVNKNLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDG3</accession>
    <name>A0A386PDG3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05910</name>
        <name evidence="9" type="ORF">EI377_00400</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675033.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34035">
        <property type="protein sequence ID" value="AYE34035"/>
        <property type="gene ID" value="CP523_05910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59408">
        <property type="protein sequence ID" value="QAS59408"/>
        <property type="gene ID" value="EI377_00400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="392" mass="43252" checksum="816B9305B89C6AEA" modified="2018-12-05" version="1">MISNFLVKTFVKDNENTRNPKVRNSYGTLGGVIGIIINSLLFLIKFSIGTLVGSIAVSADAFNNLSDAASSIITIIGFKMANKPADAEHPFGHGRIEYLSALIVAFMVMLVGIQFIKSSIERILNPQPIVFESIPFILLIVSIGFKIWLSTFNKFLGNKINSSALKAAATDALGDVFTSSTVAISFLIAKFTSFPIDGYIGILVALAILYAGFSLVKETLNPLLGEAPDPELVNSICEMVLSYENITGVHDLIVHNYGPGRVIASIHAEIPSDVDIMEIHNVIDKAEREVSKELDLHLVIHMDPICVITDEVQEAWDYVAKTLRKYPEIKSMHDFRVVGEGNIKNLIFDIVLSPSDKTSQTKIDIMVEEIKKSIKEEHPQYNCVITTDYDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDJ2</accession>
    <name>A0A386PDJ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02420</name>
        <name evidence="2" type="ORF">EI377_12945</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673969.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33394">
        <property type="protein sequence ID" value="AYE33394"/>
        <property type="gene ID" value="CP523_02420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61568">
        <property type="protein sequence ID" value="QAS61568"/>
        <property type="gene ID" value="EI377_12945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="26243" checksum="4CDA38478D3FD2E3" modified="2018-12-05" version="1">MSNKKFSFLKYSNENIEAEKKGDYPIIDPTVIEFLSKEFPHLTENIIDSLMNIQKTLESSIDSIEDKSNEIIKSDRNFSLSGKYRSSAIRLHEISMSIDKYIKWAKEEIKDSNIIKDENSNFKDSLNNISNNEDKLYIHDDFTGKHPKSFELDKFNILVEGWEDLIMNTADILIKNYKHNKDLNTIISEIKTEGKKSIENDFRDTLIEMLTEYKIDPKKYIIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDN6</accession>
    <name>A0A386PDN6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pyk</name>
        <name evidence="16" type="ORF">CP523_06330</name>
        <name evidence="17" type="ORF">EI377_00800</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677770.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02425"/>
    <dbReference type="EnsemblBacteria" id="AYE34113">
        <property type="protein sequence ID" value="AYE34113"/>
        <property type="gene ID" value="CP523_06330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59479">
        <property type="protein sequence ID" value="QAS59479"/>
        <property type="gene ID" value="EI377_00800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06330"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="14">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="15">
        <location>
            <begin position="358"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE34113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS59479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="472" mass="50132" checksum="4722183C77205335" modified="2018-12-05" version="1">MRKTKMICTIGPASEKPEILSKIIEAGMNASRHNFSHGDHEEHKARILLVKELAKKYNREIAVMLDTKGPEIRTGKFEPKKIELQAGAEFTVYAGGDVIGDATKCSVTYEGLANDVKPGNVILIDDGLVGLEVKSIEGNKIHCVVKNTGFVGTHKGVNVPGVSIKLPALTEKDIADLKFGCEIGVNLVAASFIRKASDVETIRKILAENGGEHIQILSKIENQEGVDNIDSIIEASDGIMVARGDLGVEIPMEKLPAVQKMIIEKCNIAGKPVVTATQMLDSMIRNPRPTRAEVSDVANAIYDGTDAIMLSGESANGDWPVEAVETMAKIAAEAEKQLSYKVAVSNAKSHIPAIGGVISRAAANAASELKASAIISSTQSGATAKRLSQCRPDCPIVAVTPDEKVAKKLAICFGVNPIVGEKMQSTDHMMERSVEIAKENGYVAAGDTVVVAAGVPVHTVGSTNLLKISIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDP5</accession>
    <name>A0A386PDP5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00130</name>
        <name evidence="2" type="ORF">EI377_10770</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677407.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32968">
        <property type="protein sequence ID" value="AYE32968"/>
        <property type="gene ID" value="CP523_00130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61164">
        <property type="protein sequence ID" value="QAS61164"/>
        <property type="gene ID" value="EI377_10770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="19865" checksum="30E0D363259C96F0" modified="2018-12-05" version="1">MVYEKLKDIEAGNLTNYICNFKDDITFSTFFLKETDINIKKIKDNLIIDIKDISYFSNRQAALLILFKFADSDKLIYGRWYNYSNDTDRKNLELLLFQNEIPITIVDKNNCSVFTAWCHNIFKNNIREYIKKVNRLKISSMEFDKYVSSIEDGFSNIVDVWKKTKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDQ4</accession>
    <name>A0A386PDQ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06430</name>
        <name evidence="4" type="ORF">EI377_00905</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677424.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02162"/>
    <dbReference type="EnsemblBacteria" id="AYE34133">
        <property type="protein sequence ID" value="AYE34133"/>
        <property type="gene ID" value="CP523_06430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59500">
        <property type="protein sequence ID" value="QAS59500"/>
        <property type="gene ID" value="EI377_00905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="150" mass="16994" checksum="444C34F3563DF3F8" modified="2018-12-05" version="1">MSFSRLMTFVFGIVFIIILYFIIYYALKIMYKDVKSGGKRKQASGKKNYGIEVLRSGDNPNLEEGTLLLLRAPLTIGRREDNTIQLSEPYVSGNHAKLIVKNNEVFIEDLNSTNGVFVNEEKINGSFKLKPNDKIKIGSAIFKVIRSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDQ7</accession>
    <name>A0A386PDQ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-IB family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02780</name>
        <name evidence="2" type="ORF">EI377_13305</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676976.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00962"/>
    <dbReference type="EnsemblBacteria" id="AYE33464">
        <property type="protein sequence ID" value="AYE33464"/>
        <property type="gene ID" value="CP523_02780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61635">
        <property type="protein sequence ID" value="QAS61635"/>
        <property type="gene ID" value="EI377_13305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006385">
        <property type="entry name" value="HAD_hydro_SerB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01490">
        <property type="entry name" value="HAD-SF-IB-hyp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="212" mass="25306" checksum="2E3F541BD702E297" modified="2018-12-05" version="1">MDKLAIFDVDYTITRKETLMELFKYMVYRDKKNIKFLPRAIYSGAMYALKVYDEKKVKEKFLKFIDGIDEGDLALLVKDFYKDRLTKIIYKDAINMMNNLKSEGYKIYLISASPEFYLKELYNIDSVDMIIGTKFLFKNGKFIRKMDGANCKGEEKIRRLMEVLKREKLEIDFKNSYMFSDSLSDKPLLDLVGKPYLINYKKKHNFEILRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDS6</accession>
    <name>A0A386PDS6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_06590</name>
        <name evidence="7" type="ORF">EI377_01080</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02195"/>
    <dbReference type="EnsemblBacteria" id="AYE34165">
        <property type="protein sequence ID" value="AYE34165"/>
        <property type="gene ID" value="CP523_06590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59533">
        <property type="protein sequence ID" value="QAS59533"/>
        <property type="gene ID" value="EI377_01080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788295" evidence="4">
        <location>
            <begin position="25"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="304"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="418" mass="46092" checksum="47EBAF9D84AF8560" modified="2018-12-05" version="1">MRKKILSAVIAGVLVLTSGVPAFATPNQEVTENQKKYEEITNKINGIQGEIYKLNMEIDPLAEKVENNKKEMQIIKEEIQNTTKEIETSKIEMKEKEEVLGKRLRELYKSGGQSSYLSILFSAESFSDFISKLDSTTRLVNIDKKVVKDILDKQEKMNAKVASLEEKNSEIVKVNEETEKALVEFESKRKEQEVLINSAKEEQSKFDEEFLSVAERKLVEPQLAVLNSSSSVDEIQSAIEQLRSIRDNQLKSPIVVEEIDEAIEAAKIKVDDLKAQAEAQAQAQAQIQASKPSTPNRGDNPTVSGSASGIVGYAYGLLGRPYVWGATGPDSFDCSGFTSYVYRNAAGIEITRTTYSQLGQGRAVSQGELEPGDLVFTYGGDHVGIYVGGGSYIHAPQPGDTVKVSPITSFHAARRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDU3</accession>
    <name>A0A386PDU3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_06725</name>
        <name evidence="11" type="ORF">EI377_01195</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679140.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01565"/>
    <dbReference type="EnsemblBacteria" id="AYE34185">
        <property type="protein sequence ID" value="AYE34185"/>
        <property type="gene ID" value="CP523_06725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59549">
        <property type="protein sequence ID" value="QAS59549"/>
        <property type="gene ID" value="EI377_01195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="134"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="479" mass="54894" checksum="810F9E19F37E5DD8" modified="2018-12-05" version="1">MKNFKRLFSGFVTNALKVIMLVIVIGAILLAKYLKFPINMATLIQVLFLGISGIIFYKLIKSKKFNSRNVLLYVLAIGFILRLLWLLNANTVPVSDFKTMYNSGIDVLNGDFKSLHGSGYIARFPHLTMMVLYFAFMIKTFSNSILVIKMINLILSVLTIYLIYKICKEVFEKEKYALTGAFIAAIFPPMISYIGVFCTENIAIPFYLGSIYLFIKFIKKEKGLWILALSGILLSLGNLFRMVAAVTLVAYIMYIFIYYGDKVLNKIKASIVIIASFAIILLGTSFSLRATGITEFQLWRGSEPAITNVLKGINIEHNGRWNEEDAAIPELCNYDYEKMEKMSKEIIMKRLTTTPPLDLFKFYVKKFGAQWSNGDLEGVFWTIISKEDRKMIVDLENGNIPIMPTFQWIYVVIMLLAYLSLFNRKRIKNETINLFYIIFCGYGLSYLVTESQGRYAYIVSWLFIIFAVSGIEKIKTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDX5</accession>
    <name>A0A386PDX5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6Y C5,15-methyltransferase (Decarboxylating) subunit CbiT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbiT</name>
        <name evidence="4" type="ORF">CP523_01470</name>
        <name evidence="5" type="ORF">EI377_11990</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675623.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00846"/>
    <dbReference type="EnsemblBacteria" id="AYE33221">
        <property type="protein sequence ID" value="AYE33221"/>
        <property type="gene ID" value="CP523_01470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61393">
        <property type="protein sequence ID" value="QAS61393"/>
        <property type="gene ID" value="EI377_11990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01470"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="3">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="192" mass="21545" checksum="B455373E0480E4F5" modified="2018-12-05" version="1">MILIKDEEFIRGNCPMTKEDIRALSIWKMDLNEDSKVLDIGSGTGSITIQASKIAFKGQVYAIEKALDAIEVTKKNIEKFKGENIKLFEGEAVDILDNFKKENLNFNSIFIGGSSGSLEKIILGSNELIKNNGTIVMNFITLDNAYKAIDLMKTLNYKVDISMVNISKNKGDSYMMIANNPIYIVKCTRREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE11</accession>
    <name>A0A386PE11_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_07280</name>
        <name evidence="12" type="ORF">EI377_02030</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673750.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01073"/>
    <dbReference type="EnsemblBacteria" id="AYE34265">
        <property type="protein sequence ID" value="AYE34265"/>
        <property type="gene ID" value="CP523_07280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59671">
        <property type="protein sequence ID" value="QAS59671"/>
        <property type="gene ID" value="EI377_02030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="224" mass="25782" checksum="22C56232C99F7178" modified="2018-12-05" version="1">MAKILVVDDEEKLRGVIKKYAEFDGYEVIEAADGMEAVLRCEKEDFDIIIMDVMMPELDGFSAVKEIRKSSDVPVIMLSARGEEYDKLHGFDLGIDDYVVKPFSSKEIMRRVSAILRRVGTNVQKINHDLFKKDGLVVDITAHKVTIDGEDIDMSPKVYELLFYMIRNKNIALSRERLITEVWGYDYFGDDRTLDTHIKLLRQALGKYSKLVVTLRNIGYRFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE72</accession>
    <name>A0A386PE72_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_04350</name>
        <name evidence="9" type="ORF">EI377_14885</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00408"/>
    <dbReference type="EnsemblBacteria" id="AYE33757">
        <property type="protein sequence ID" value="AYE33757"/>
        <property type="gene ID" value="CP523_04350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61914">
        <property type="protein sequence ID" value="QAS61914"/>
        <property type="gene ID" value="EI377_14885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="242" mass="28177" checksum="019CCC2A780BB4AB" modified="2018-12-05" version="1">MGNHMIKIAICDDNRYERKNLISILKKIALSNNIEIDIEEFEKGHVLIDTYIKDLPRYNIIFLDILLGDINGLEVARVIREKDILAKVILLSSSKEYILDGYDVAAMSYLIKPATEEKIEKNLLRAIEESKINSIDSYEANKSGKTIIFDLKDIFYFEARLGKVILHKKDSNFEFYEKINSIDKKLNKKGFERCHRSYIINISKIKEFKNTEVILANEKSIPIGRKYKGNIKEAFMQYLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH3</accession>
    <name>A0A386PEH3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coproporphyrinogen III oxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_01720</name>
        <name evidence="7" type="ORF">EI377_12240</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02407"/>
    <dbReference type="EnsemblBacteria" id="AYE33268">
        <property type="protein sequence ID" value="AYE33268"/>
        <property type="gene ID" value="CP523_01720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61439">
        <property type="protein sequence ID" value="QAS61439"/>
        <property type="gene ID" value="EI377_12240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="413" mass="47662" checksum="1716B4B00BA2F015" modified="2018-12-05" version="1">MVTNIFRIIATRSFKAISFTNKIEEMDSNMKELGLYVHIPFCEKLCPFCPYNKVEFDKNLANEYKDALIKEIENMGVFYGEKNITSVYFGGGTPALMIDSLGEIIKALKYNFNIKANIGIELHPRDINEIMLRSLIDIGFDMVSIGIQSFNKDNLKTLGREYINGAEKINLVKNAGFKVIDVDLIFGIKGQTKENLIEDFEIAIKNGATQVSTYPFIDFSYAKNKSKPMGKYEKKELLQSLESISENLGLKRTSVWTFGKEGISKYSSITRDSYIGFGPSAATLTNNYFKINTFSVPEYIKVMDTKLTATSLTMDFTKRVRALYWGFWNAYTLEFNSKSFKDLFNEDLDKFFKIELFLARVLGMIEKIDSGYKLTKRGTYIYHLLEQHYTHQYIDKTWRICSNEPWPKEIKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ2</accession>
    <name>A0A386PEJ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08430</name>
        <name evidence="3" type="ORF">EI377_03175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674804.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34453">
        <property type="protein sequence ID" value="AYE34453"/>
        <property type="gene ID" value="CP523_08430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59856">
        <property type="protein sequence ID" value="QAS59856"/>
        <property type="gene ID" value="EI377_03175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="274" mass="31097" checksum="719B95C02350CE3C" modified="2018-12-05" version="1">MILNELKRVITSKKFIIVIFIGLLIASISVYIDIKQYIFFNYDAPDIQTPELQEKAKIMVENGLNKYSVFFSSFLMSIVTMPILSVLPFGLSYIEDKEYGIIKQIDMRINHRKYILSKLLVNGIAGGLAIIIPTIILSILIFTFLKGNITSFYGYGKIGGPFAKLLTENFGIYIMMHMFINFILGFAYANIGLAISAFIKNKIAIILSPFLFWILGSMFCSILNIYNYSPSSISQFYRSADMTVSNIFVEIIVIIVLFSTLFISKTKKGDIYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK5</accession>
    <name>A0A386PEK5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_07125</name>
        <name evidence="6" type="ORF">EI377_01870</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673709.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01040"/>
    <dbReference type="EnsemblBacteria" id="AYE34240">
        <property type="protein sequence ID" value="AYE34240"/>
        <property type="gene ID" value="CP523_07125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59645">
        <property type="protein sequence ID" value="QAS59645"/>
        <property type="gene ID" value="EI377_01870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="74"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="241" mass="27353" checksum="D076F0256DF13935" modified="2018-12-05" version="1">MIRSIIWYIYFFLSLIMSIPAIFKVKRLEKNGLLQEKKEYVHKYTSGWARGLLKVAGVKVTIYGAENLPKDRTVLFVGNHQGNFDIPIYMSQIDVPKGFIAKTEIKKMAGVRTWMEFMNCVFMDRSNIRKAGEAIIHGIKNLKNGDSMVIFPEGTRSKGDKMADFKAGSFKLATKSKAPIVPITMNGSYKIMEGSKGPWIRPAEVELYIHPLIETAHLTKEEQDELPKTVQNIIKSKLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEL3</accession>
    <name>A0A386PEL3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid-soluble spore protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Alpha/beta-type small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_02815</name>
        <name evidence="5" type="ORF">EI377_13340</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676988.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00969"/>
    <dbReference type="EnsemblBacteria" id="AYE33471">
        <property type="protein sequence ID" value="AYE33471"/>
        <property type="gene ID" value="CP523_02815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61642">
        <property type="protein sequence ID" value="QAS61642"/>
        <property type="gene ID" value="EI377_13340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="6530" checksum="64AF641AF4DB6381" modified="2018-12-05" version="1">MAKTLVPEAKNGLAKFKNEVASEMGVPFTDYNGDLSSKQCGSVGGEMVKRMVQQYENGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN7</accession>
    <name>A0A386PEN7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AP endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00303"/>
    <dbReference type="EnsemblBacteria" id="AYE32952">
        <property type="protein sequence ID" value="AYE32952"/>
        <property type="gene ID" value="CP523_00050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="270" mass="30582" checksum="EDF2BAC13FC62BF4" modified="2018-12-05" version="1">MGNLLFGISGLPIGEDDKFTYPTGIEYLHSIGLDAMELPFVRSVNVTPKNRPSILEAKEKFDFYLSAHGSYFINLNAEVEEKRKKSIERILQGSEALRSIGGKSLVFHPGFYLKSSKEEALEEIKKNILTLPNNIDYRLETTGKPTQFGDIDELINICSEIPYCKLCIDFSHIHARENGKLKEYSDFARILDKVGEGLGKDTLSDLHIHLSGIEYSPKGEKYNLPFEESDFNYKDCLKALINYNIKGCLICESPILEHDALLLKNTYESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PET9</accession>
    <name>A0A386PET9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">CP523_09095</name>
        <name evidence="6" type="ORF">EI377_03840</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008681165.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00258"/>
    <dbReference type="EnsemblBacteria" id="AYE34565">
        <property type="protein sequence ID" value="AYE34565"/>
        <property type="gene ID" value="CP523_09095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59965">
        <property type="protein sequence ID" value="QAS59965"/>
        <property type="gene ID" value="EI377_03840"/>
    </dbReference>
    <dbReference type="GeneID" id="66300478"/>
    <dbReference type="KEGG" id="csep:CP523_09095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="8197" checksum="00A884A2E35718B6" modified="2018-12-05" version="1">MSKDDVIEMQGTVLESLPNAMFQVELESGHKILAHISGKLRMNFIRILPGDKVTIELSPYDLTRGRITWRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY4</accession>
    <name>A0A386PEY4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIM24 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09285</name>
        <name evidence="2" type="ORF">EI377_04030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34603">
        <property type="protein sequence ID" value="AYE34603"/>
        <property type="gene ID" value="CP523_09285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60003">
        <property type="protein sequence ID" value="QAS60003"/>
        <property type="gene ID" value="EI377_04030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="277" mass="30714" checksum="613BD8114DA1A2D3" modified="2018-12-05" version="1">MRTSMNISNKLAMISEMRNDTIFQVLEYDDLEGASNLNTAIQLDFMRKSNIKLRQVRIILDESAVKLEAGALSYMKGDIEIINKTGGIIGLGKKFFASKVTNESAFKPLFQGKGEIFLEPSFAHYALIELEDEEIIVDDGLFYACEESIEVGVAMQKNASSIVFGNEGIYQTKLKGSGIVLLEIPVPEKEILRCKMYRDTLKVDGNFALLRSANIEFTVEKSGTTLIGTALNGEGLLNVYRGTGEVWLAPTKSVYNDLEDKGLKELTVSSKNRDTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA5</accession>
    <name>A0A386PFA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DMT family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">EamA/RhaT family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04050</name>
        <name evidence="6" type="ORF">EI377_14570</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676915.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02776"/>
    <dbReference type="EnsemblBacteria" id="AYE33701">
        <property type="protein sequence ID" value="AYE33701"/>
        <property type="gene ID" value="CP523_04050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61856">
        <property type="protein sequence ID" value="QAS61856"/>
        <property type="gene ID" value="EI377_14570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362708" evidence="3">
        <location>
            <begin position="28"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="4">
        <location>
            <begin position="146"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="32033" checksum="D5B02FBBD1BC899A" modified="2018-12-05" version="1">MKNKNKAIVLMLISALGFALMSTFVKLAGDLPSIEKSFFRNFISLIVATYIIIRSKASFVGKSENRRALIFRSLFGTLGIIANFYAIDHLILADANMLNKLSPFFVIIFSFIFLKEKISNKQIFALVIAFSGSLFIIKPTFSVEMLPAIIGISSAIFAGAAYTFVRYLGGKEKGATIVFMFSAFSCITTLPLVILNFKIPSLTQLIYLLLAGVCASSSQFALTEAYKNAPAKEVSIYDYSQIIFSAIIGFIIFNQIPDYLSIIGYIFIIGASIYMFFYNKKSASSVTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF6</accession>
    <name>A0A386PFF6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03560</name>
        <name evidence="9" type="ORF">EI377_14085</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02233"/>
    <dbReference type="EnsemblBacteria" id="AYE33608">
        <property type="protein sequence ID" value="AYE33608"/>
        <property type="gene ID" value="CP523_03560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61772">
        <property type="protein sequence ID" value="QAS61772"/>
        <property type="gene ID" value="EI377_14085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="662" mass="74781" checksum="8BEC86CCFB83C6E6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL0</accession>
    <name>A0A386PFL0_CLOSE</name>
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        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA polymerase subunit sigma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04600</name>
        <name evidence="5" type="ORF">EI377_15155</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE33801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33801">
        <property type="protein sequence ID" value="AYE33801"/>
        <property type="gene ID" value="CP523_04600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61958">
        <property type="protein sequence ID" value="QAS61958"/>
        <property type="gene ID" value="EI377_15155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="172" mass="20766" checksum="1AF508B7D0B3B22B" modified="2018-12-05" version="1">MNIENMIDIYKDDVYKICLKLTSNKTDADDLFQETWLKIYNNLYKIDKQKSIRNWIYTICINTYKDSYSKKKRWLRVITDFFDSKVKHEIMEQQTSSIDETELIVFNNIEKERIQKLVKTLDEKYKLPIIMYYYLDYSYSDIATTLNIPVGTVKYRLNHGKKLLKTKLKNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG30</accession>
    <name>A0A386PG30_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05545</name>
        <name evidence="2" type="ORF">EI377_00180</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33971">
        <property type="protein sequence ID" value="AYE33971"/>
        <property type="gene ID" value="CP523_05545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59367">
        <property type="protein sequence ID" value="QAS59367"/>
        <property type="gene ID" value="EI377_00180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="184" mass="21551" checksum="4CDD47A6F608A272" modified="2018-12-05" version="1">MKIWSLEEDVNHYEHITLDDRNNLNWIDFGDMFNGKSLKDNWTPIRVCLIEHGGKLKKGDMPYLSPGKPIFSKSAVTILKDLLEGYAEILPIEYDLQELFIINVTNHIEAINYEKSDVEYMRDGKRILSVNKYYFKIEVVKKQHIFKIVNQLNGTVFVSDDFRNRVIEGGLQGFKFVEVWDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG44</accession>
    <name>A0A386PG44_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11625</name>
        <name evidence="3" type="ORF">EI377_06440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673361.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02883"/>
    <dbReference type="EnsemblBacteria" id="AYE35013">
        <property type="protein sequence ID" value="AYE35013"/>
        <property type="gene ID" value="CP523_11625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60406">
        <property type="protein sequence ID" value="QAS60406"/>
        <property type="gene ID" value="EI377_06440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="1">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="227" mass="25495" checksum="5E4317111C19EB56" modified="2018-12-05" version="1">MAKWIIDAGHGGNDSGAIGLNERRESDIVLEAAYEAKRLLEKNGETVLLTRAADISLDLDTRAEIANKWDADYFVSLHMNSFVNKSITGSEVLISENEYTGEELAKLIRDELISNLKSNDRGIKKSNDEILKLTNMPTIIVNAEFISNEEVEKSFDSQKYGYMIAKACLAKVDKVLIDLPVLKPKTPWKSSWRVCIGHFKNYDDVEAAVKKAKKQGYEDAYIIPYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG50</accession>
    <name>A0A386PG50_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid-soluble spore protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Alpha/beta-type small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11760</name>
        <name evidence="5" type="ORF">CP523_11765</name>
        <name evidence="6" type="ORF">EI377_06580</name>
        <name evidence="7" type="ORF">EI377_06585</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673400.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02911"/>
    <dbReference type="EnsemblBacteria" id="AYE35034">
        <property type="protein sequence ID" value="AYE35034"/>
        <property type="gene ID" value="CP523_11760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35035">
        <property type="protein sequence ID" value="AYE35035"/>
        <property type="gene ID" value="CP523_11765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60428">
        <property type="protein sequence ID" value="QAS60428"/>
        <property type="gene ID" value="EI377_06580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60429">
        <property type="protein sequence ID" value="QAS60429"/>
        <property type="gene ID" value="EI377_06585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11760"/>
    <dbReference type="KEGG" id="csep:CP523_11765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="6484" checksum="64A9AEABAEDB6381" modified="2018-12-05" version="1">MAKTLVPEAKNGLAKFKNEVASEMGVPFTDYNGNLSSKQCGSVGGEMVKRMVQQYESGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGB3</accession>
    <name>A0A386PGB3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_10630</name>
        <name evidence="10" type="ORF">EI377_05415</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674161.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01376"/>
    <dbReference type="EnsemblBacteria" id="AYE34820">
        <property type="protein sequence ID" value="AYE34820"/>
        <property type="gene ID" value="CP523_10630"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60215">
        <property type="protein sequence ID" value="QAS60215"/>
        <property type="gene ID" value="EI377_05415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10630"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="8">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="286" mass="33345" checksum="E65B036BE8B43345" modified="2018-12-05" version="1">MKKEAKIFLAEIVLIMLICTSSEVFLSAFLWVILHEISHITLACMFGCKFYNIELHIFGVRAELGDLEILTDIKRMLIYLAGPLFNFIMFIIFSIISLRYSSPWIIASLNLNLGLAIFNLLPAYPLDGSRIYEILISKKILYKQAQKIIRLTSYCIAISFVCISLLLFISIHKLNLSMFIAACIIIYITRSEQRSTMYITMGNMVKKRKKLIKNKYIENKTVSVYYKNYLVNVLGLVDRNKFNTFYVLDDDMNLLYILQENELIDALKFYGNITLEEYKDIRLQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR2</accession>
    <name>A0A386PGR2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">CP523_02265</name>
        <name evidence="11" type="ORF">EI377_12785</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674017.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00514"/>
    <dbReference type="EnsemblBacteria" id="AYE33369">
        <property type="protein sequence ID" value="AYE33369"/>
        <property type="gene ID" value="CP523_02265"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61539">
        <property type="protein sequence ID" value="QAS61539"/>
        <property type="gene ID" value="EI377_12785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02265"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="DnaJ_domain_CS"/>
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        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
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        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
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        <property type="entry name" value="J_dom_sf"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="134"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="376" mass="40757" checksum="D66EE43DEDC33928" modified="2018-12-05" version="1">MANKDYYASLGLEKGASDEEIKRAFRKLAIKYHPDKNQGNKEAEDKFKEINEAYQVLSDPEKKARYDQFGTADFDGSGFGSGGFGGFDFSDMGGFGDIFDSFFGGSGGRRRNGPQRGDDLEYTLNLTFEEAVFGVEKEISINRSENCDSCRGTGAKAGTTPKTCPTCNGSGQVRVQRQTPLGSFVSTSTCDRCGGKGKIVEEPCQKCSGKGKVRKNRKIKINIPAGVDTGNVMPLRGQGEHGTNDGPPGDLYIRINVAPSKKFVRKGNDIYVDAHISMAKAALGTEITVATVDGDVKYTIPQGTQSGTLFRLKGKGVPRVNSSGRGDQYVKVIVDIPKSLNEKQKEALKMFMEASGESVDEVVTHKKGFKDLFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX3</accession>
    <name>A0A386PGX3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02902"/>
    <dbReference type="EnsemblBacteria" id="AYE35030">
        <property type="protein sequence ID" value="AYE35030"/>
        <property type="gene ID" value="CP523_11715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11715"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="692" mass="82043" checksum="2E1A3365DE4CE7C9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH12</accession>
    <name>A0A386PH12_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06685</name>
        <name evidence="2" type="ORF">EI377_01150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679214.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34178">
        <property type="protein sequence ID" value="AYE34178"/>
        <property type="gene ID" value="CP523_06685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59541">
        <property type="protein sequence ID" value="QAS59541"/>
        <property type="gene ID" value="EI377_01150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="69" mass="7483" checksum="FA1B5FEBD47C407D" modified="2018-12-05" version="1">MIDLFSLSSDQLIVVAAFIAADIAQSLTSEEQEIVAWLFEAIGQNLSVFGAVEALRQKNNKNDDSGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH26</accession>
    <name>A0A386PH26_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06745</name>
        <name evidence="2" type="ORF">EI377_01220</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34188">
        <property type="protein sequence ID" value="AYE34188"/>
        <property type="gene ID" value="CP523_06745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59552">
        <property type="protein sequence ID" value="QAS59552"/>
        <property type="gene ID" value="EI377_01220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="17018" checksum="8635B80BB2608D14" modified="2018-12-05" version="1">MIRTMVCQKEGCSGNRFRIQADDGKIQLTCDQCKSKYYIETSSDDVIMLPNCSKCNNETFKIFRDVNKKAVYAKCTECGSEPEMMYIDSDGTQVSYEAKLLNDIKEVMSLVEQRMCNLERNVQDLEQGQDMLEQSLAYINRYIVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH28</accession>
    <name>A0A386PH28_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35383">
        <property type="protein sequence ID" value="AYE35383"/>
        <property type="gene ID" value="CP523_13620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="66" mass="7691" checksum="25C900CAF373244A" modified="2018-12-05" version="1">MIIFLLCINVRRGFSYSYNNIAINYIVMIVVILKLVEIIISIIIKTILKFKAKIEKICEDSNEKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH48</accession>
    <name>A0A386PH48_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06985</name>
        <name evidence="8" type="ORF">EI377_01470</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673663.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01012"/>
    <dbReference type="EnsemblBacteria" id="AYE34218">
        <property type="protein sequence ID" value="AYE34218"/>
        <property type="gene ID" value="CP523_06985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59583">
        <property type="protein sequence ID" value="QAS59583"/>
        <property type="gene ID" value="EI377_01470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06985"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="24937" checksum="E067B0E14E8D40D8" modified="2018-12-05" version="1">MVLGIISAMSEELEILLKDMTLEEKVEKANMTFNKGKLGNTSIIAVVSGIGKVNAAVCAQILISEYKVDSIINVGVAGGIGKDIYPGDVVVATDLVQHDIDTTVFGDPHGQVPRLNTFAFKCDEGLVKAAMDACEEITEINTFSGRIVSGDQFISSVEKIQWFEKEFGAISCEMEGASIAHVCYLNNIPCVVIRSISDNANNGAHMDYEKFIPLGVRNSTAILKTMINKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH51</accession>
    <name>A0A386PH51_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08055</name>
        <name evidence="3" type="ORF">EI377_02815</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675942.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00726"/>
    <dbReference type="EnsemblBacteria" id="AYE34381">
        <property type="protein sequence ID" value="AYE34381"/>
        <property type="gene ID" value="CP523_08055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59787">
        <property type="protein sequence ID" value="QAS59787"/>
        <property type="gene ID" value="EI377_02815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="395" mass="44191" checksum="C9C5329E0AE0E39F" modified="2018-12-05" version="1">MSNFFTVLKKELLDIFRDKKTLVFTLILPILLYPLMFKFMSSSIEKTQKDAEKEINIVIEGDSNSLMAKTLTSLENIKTHTVDSPTESLKKGDIQLIVKIPENFDKDMLEGKQSSIELLIDEESNKSMIASNMVNSIYDKYKDNIVQARLSENGIDPSILKPFEVEIKSGINVDNNEVNGMASMLLTMIPTLIVILMISSTVGMAADLGAGEKERFTFEPLLSTSAKRNSLLWGKIAALCTVSFISLSANLVVMILSMQKFMSFGSTELSFNLDPITVIGILVICILLLITLCSMQISVSLYARSTKEANSYLVATTMPTMLLAFIPYMMDAKSINPVFFNIPITNSICLMKEFVVGIFDIKHIVIVLAWHIVYIVAAIIFAKFMFSREEVIFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH57</accession>
    <name>A0A386PH57_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LrgB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_13775</name>
        <name evidence="7" type="ORF">EI377_08665</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677149.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02067"/>
    <dbReference type="EnsemblBacteria" id="AYE35413">
        <property type="protein sequence ID" value="AYE35413"/>
        <property type="gene ID" value="CP523_13775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60801">
        <property type="protein sequence ID" value="QAS60801"/>
        <property type="gene ID" value="EI377_08665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="24720" checksum="D402FB57BF2A873A" modified="2018-12-05" version="1">MNILTSNILFGIVLSLLSFEIGLLIYKKTKMPIFNPLLIAIAIIIAVLVIFNIDFNSYNNGGQFINMFLGPATVVLAVPLYKQFHLLKENFVPIIIGIFVGCLVGIFSVIALCISFGIENVLTKSLLAKSVTTPIGIEITNQLGGLVPVTVLAIILSGIIGAVAGPTLCKLFKIKNELAIGIAIGTASHAVGTTKALELGETQGAMSSLSIGIAGIMTVFLAPICFKLITLFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH86</accession>
    <name>A0A386PH86_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08270</name>
        <name evidence="4" type="ORF">EI377_03020</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674731.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34421">
        <property type="protein sequence ID" value="AYE34421"/>
        <property type="gene ID" value="CP523_08270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59826">
        <property type="protein sequence ID" value="QAS59826"/>
        <property type="gene ID" value="EI377_03020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010343">
        <property type="entry name" value="ArAE_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06081">
        <property type="entry name" value="ArAE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="177" mass="19343" checksum="32CE0151338C3F84" modified="2018-12-05" version="1">MKNLELPRIGSRNLKTAISVCICLILFRADPFYSAIASVICMQGTVENSVKSGINRLIGTLLGGVTGVILLSFTRYFNFEVIIPLITAFGIIFVIYTCNLIKKPASCTISCIVLIAIMIAPETSNPLFYASRRTIETALGILVAVLVNKYINPPEKKLVDTNNKNNPSNEGENNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC6</accession>
    <name>A0A386PHC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_10505</name>
        <name evidence="7" type="ORF">EI377_05290</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674207.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01399"/>
    <dbReference type="EnsemblBacteria" id="AYE34797">
        <property type="protein sequence ID" value="AYE34797"/>
        <property type="gene ID" value="CP523_10505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60192">
        <property type="protein sequence ID" value="QAS60192"/>
        <property type="gene ID" value="EI377_05290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NeuB" evidence="5">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="292" mass="32770" checksum="5140E2FF134D2EF5" modified="2018-12-05" version="1">MKKKLIATGLIILGIISSVGCTTKEKQDNTSKLRVQVTISPLKEFAESIGGDKIEVSSIIPNGSEPHDFEPKPKDLEALTNSDVFIYNGLDMEHWLEPVLGTIKDKNVEVVNSSDGVNVIKTDGKEDPHAWLSLKEATKQAENIKDALVKKDSVNKEFYEENFKKLKNEFDSLYSEYEVKFQEIKNKDFVTGHAAFGYLCRDFGLTQKSIADIYGEGELTPKTLEELVNYCKDNNVKTIFSESTASSKESETLAKEAGAKVEKIYSLETKEDNKTYLDGMKYNLEKILEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD9</accession>
    <name>A0A386PHD9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-IIB family hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05810</name>
        <name evidence="2" type="ORF">EI377_00295</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01862"/>
    <dbReference type="EnsemblBacteria" id="AYE34016">
        <property type="protein sequence ID" value="AYE34016"/>
        <property type="gene ID" value="CP523_05810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59388">
        <property type="protein sequence ID" value="QAS59388"/>
        <property type="gene ID" value="EI377_00295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="253" mass="28946" checksum="AA6274C879D96DC3" modified="2018-12-05" version="1">MKKLLATDLDGTLINNNRISDNNKQAINNLKNNNHILVVSTGRPYNGITFLKEEDNVVADYYVLLNGALIIDKEGKTVKHEVIKYNDIVSILKNFQKENMAISVETGYTTYVLTKWDNLPYADKTNLNSIEELKDKEISLISMYCKDIDKVVIEEMKNEINKKYGDKIIAYRNDVYIDIVPVGCSKGHGVEYVAKVENLDKKSIYTIGDSWNDLTMFNITDNSFTFNNVEEELKKYVNNLVDSVAECIIEYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF5</accession>
    <name>A0A386PHF5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14445</name>
        <name evidence="6" type="ORF">EI377_09420</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676822.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02482"/>
    <dbReference type="EnsemblBacteria" id="AYE35535">
        <property type="protein sequence ID" value="AYE35535"/>
        <property type="gene ID" value="CP523_14445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60922">
        <property type="protein sequence ID" value="QAS60922"/>
        <property type="gene ID" value="EI377_09420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PTHR11022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PGRP" evidence="4">
        <location>
            <begin position="75"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="27075" checksum="06CF693CA0FB8E7C" modified="2018-12-05" version="1">MAKKKRNLLVKDKIWLYLFIAMIITCVTCSITYFKYDIMNFYKVSYRNIYGKKLDEKKLNEIRDELNIKEIDYNWDGELEYINNPRKIIYHHSANNGWTSENIHEAHKNKGWNGIGYHYYIRKDGVIYKGRPEKAEGAHTKGQNKESIGICLEGNFEEDRLTLEQVESLYELSVYISLKYDIYKIIGHKDAWNTLCPGENFPIESMARKVIKGIKEFNIEENRITPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ0</accession>
    <name>A0A386PHQ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="6 14">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ptsP</name>
        <name evidence="22" type="ORF">CP523_09225</name>
        <name evidence="23" type="ORF">EI377_03970</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="23 25" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 25">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="6 14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678327.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03053"/>
    <dbReference type="EnsemblBacteria" id="AYE34591">
        <property type="protein sequence ID" value="AYE34591"/>
        <property type="gene ID" value="CP523_09225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59991">
        <property type="protein sequence ID" value="QAS59991"/>
        <property type="gene ID" value="EI377_03970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="22" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="14 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="21">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="19">
        <location>
            <begin position="151"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="20">
        <location>
            <begin position="249"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="16">
        <location>
            <begin position="452"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="15">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AYE34591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QAS59991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="539" mass="59594" checksum="CC162FF2EDD0663B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR0</accession>
    <name>A0A386PHR0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">nusB</name>
        <name evidence="8" type="ORF">CP523_15055</name>
        <name evidence="9" type="ORF">EI377_10010</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676021.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01273"/>
    <dbReference type="EnsemblBacteria" id="AYE35645">
        <property type="protein sequence ID" value="AYE35645"/>
        <property type="gene ID" value="CP523_15055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61032">
        <property type="protein sequence ID" value="QAS61032"/>
        <property type="gene ID" value="EI377_10010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="7">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="134" mass="15586" checksum="AD714F47896BADE4" modified="2018-12-05" version="1">MNRKRSREIAMELLFGMTLSKNTLEETIETFKEDYEMKLKTIDLEYIKGILEKVEKNLEVIDEKIEKSLTNWKIERISKVNLTILRIAIAEMMFLEDVPNKVAINEAIEVTKKYSDEKSVAFINGVLDKALKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX9</accession>
    <name>A0A386PHX9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678782.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35693">
        <property type="protein sequence ID" value="AYE35693"/>
        <property type="gene ID" value="CP523_15335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="118" mass="13870" checksum="63671CB9FAA612B9" modified="2018-12-05" version="1">MINVKDQVYKSIKDICINVSDSYPSEWAKLPAIQYIEEDNKVYEYTDGREDKSYVRYKIDIWHNRSTSQYALAVDKNISKLGLQRTMCQDVSDPSGLKHKVMRYEGVIDNETEFVYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ8</accession>
    <name>A0A386PHZ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid-soluble spore protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Alpha/beta-type small acid-soluble spore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_10490</name>
        <name evidence="5" type="ORF">EI377_05270</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674211.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01402"/>
    <dbReference type="EnsemblBacteria" id="AYE34794">
        <property type="protein sequence ID" value="AYE34794"/>
        <property type="gene ID" value="CP523_10490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60189">
        <property type="protein sequence ID" value="QAS60189"/>
        <property type="gene ID" value="EI377_05270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="60" mass="6512" checksum="5BAB3A606CFD2D6C" modified="2018-12-05" version="1">MSKALVPEAKNGLNAFKNEVASEIGILFSDYNGDLTARQCGSVGGEMVKRMVEQYESSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI15</accession>
    <name>A0A386PI15_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33809">
        <property type="protein sequence ID" value="AYE33809"/>
        <property type="gene ID" value="CP523_04640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="112" mass="13125" checksum="AA1DB6840517DA09" modified="2018-12-05" version="1">MINIKSIVDEIPSIKKMKDEIKGMKLLGFLGGEDVKRQIREAENNLNKFISQIELFNERFSDKGWIVYDKLSSTLIEEVNKVYDENGEEMAEKVLITYYSSKVEESLFFFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI45</accession>
    <name>A0A386PI45_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_15700</name>
        <name evidence="5" type="ORF">EI377_10420</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678599.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00551"/>
    <dbReference type="EnsemblBacteria" id="AYE35763">
        <property type="protein sequence ID" value="AYE35763"/>
        <property type="gene ID" value="CP523_15700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61102">
        <property type="protein sequence ID" value="QAS61102"/>
        <property type="gene ID" value="EI377_10420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="4"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="242" mass="27835" checksum="EBB244426DA6152D" modified="2018-12-05" version="1">MREKIAIISDVHGNLNALNTVFNDINKRGITRIICLGDLVGKGPNTEEVVDKVKNNCEIVIKGNWDYLVSEVNNKYFVKWHKEKLRNDQLEYLKNLPIYSEFYISGNLVRIFHSSIKDLFFRVAVESTKEDKLKLFIPPQLNGKEADIVIYGHLHYAFIEYFAGKTLINVGSVGNPLEISEAAYAIIEGEYNSKKKDVISTSIIRIPYDVNKSIEDAEKSDMPDKEEYIYELKYAIYRGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI51</accession>
    <name>A0A386PI51_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07390</name>
        <name evidence="3" type="ORF">EI377_02080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673776.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01087"/>
    <dbReference type="EnsemblBacteria" id="AYE34286">
        <property type="protein sequence ID" value="AYE34286"/>
        <property type="gene ID" value="CP523_07390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59680">
        <property type="protein sequence ID" value="QAS59680"/>
        <property type="gene ID" value="EI377_02080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="263" mass="29084" checksum="D2BC8FD3796A5885" modified="2018-12-05" version="1">MKFCSLYSGSSGNSIFIASNEAKVLIDAGLPGKKIDEALKKIGENPSDIDGIFITHEHSDHIKGVGVVSRKYNVPIYANANTWSAMESSIGKIKEHNIKIIDRRSTISIKDLDIKSFNIPHDAIAPCGYTLHSKGKYVSVATDFGIYTQEIKDNIKDSEVILLESNHDVSMLKFGPYPYTLKRRILSEVGHLSNEDCGKAIVDLLKHQVGKKIILGHLSGTNNHPDLAFQTVIDVLNENKIVQGKDIMLSMASRHEPSNIIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH0</accession>
    <name>A0A386PIH0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08225</name>
        <name evidence="3" type="ORF">EI377_02975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674707.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34412">
        <property type="protein sequence ID" value="AYE34412"/>
        <property type="gene ID" value="CP523_08225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59817">
        <property type="protein sequence ID" value="QAS59817"/>
        <property type="gene ID" value="EI377_02975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="8052" checksum="8362D6E8680F86E5" modified="2018-12-05" version="1">MKYNSDMIYLSDEEIKRLTIYLAYGVGLGVLSGIFMDNIIFGFSLGGVISIIIALLICFINKVSKNTLDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII0</accession>
    <name>A0A386PII0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BMC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12460</name>
        <name evidence="4" type="ORF">EI377_07345</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675324.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02021"/>
    <dbReference type="EnsemblBacteria" id="AYE35167">
        <property type="protein sequence ID" value="AYE35167"/>
        <property type="gene ID" value="CP523_12460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60570">
        <property type="protein sequence ID" value="QAS60570"/>
        <property type="gene ID" value="EI377_07345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="101" mass="10992" checksum="307AC2B7C3816692" modified="2018-12-05" version="1">MDFRIIKSPSKNTKDILRRRMGGEGIKELDSADAIGLVQGKLIDMIYVADIAEKAVGVTVSDIRGTCPQHMVLLGIFGDTASVESAIKEIQLKMKEGKKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII4</accession>
    <name>A0A386PII4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08325</name>
        <name evidence="3" type="ORF">EI377_03070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674762.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01606"/>
    <dbReference type="EnsemblBacteria" id="AYE34432">
        <property type="protein sequence ID" value="AYE34432"/>
        <property type="gene ID" value="CP523_08325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59835">
        <property type="protein sequence ID" value="QAS59835"/>
        <property type="gene ID" value="EI377_03070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362727" evidence="1">
        <location>
            <begin position="27"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="279" mass="32380" checksum="A2D7EE53D0BF88F6" modified="2018-12-05" version="1">MLNRKISVCILLIILISLNFVGCDSIDNLKTKFGGKNEYFEYLNTAKSDKISIQSIRDPGFKFIVTDPKAIKDMYELLSSAKIADKKAELDPDYIFEINVGDEVKKFYYVVGAYEGNFYDGNTNFTVSKRLDEGIIQNLSIIRKPRDFEYVYYRSILDVLEMKKSGLNNGEYKIGINIQGDIDCLKYVFSTDLKDFLKNARKINPNVDLVKNNSNEFDVVITIKNRGYNNTTYKTNITFENKKDKIKEEFYVMATNEFKEWAIDIYEEENLPKAIKAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK8</accession>
    <name>A0A386PIK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoVT</name>
        <name evidence="3" type="ORF">CP523_08535</name>
        <name evidence="4" type="ORF">EI377_03285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674869.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01648"/>
    <dbReference type="EnsemblBacteria" id="AYE34472">
        <property type="protein sequence ID" value="AYE34472"/>
        <property type="gene ID" value="CP523_08535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59874">
        <property type="protein sequence ID" value="QAS59874"/>
        <property type="gene ID" value="EI377_03285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014213">
        <property type="entry name" value="SpoVT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026579">
        <property type="entry name" value="Spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02851">
        <property type="entry name" value="spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="182" mass="20187" checksum="3CEF7B09374DEE13" modified="2018-12-05" version="1">MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFTDREGGVILKKYSPIGELTDFSKEYAESLQQSIGHIVLIADKDAFISASGAPKKDYIERKVSSELEKIMDDRKAVLINDEGKTILLHNDEEQGKYSSQVIAPIIAEGDAIGAVIILSKQSGEKFSEIELKLAETAASFLGKQMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN2</accession>
    <name>A0A386PIN2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaX</name>
        <name evidence="7" type="ORF">CP523_08640</name>
        <name evidence="8" type="ORF">EI377_03390</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674905.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01669"/>
    <dbReference type="EnsemblBacteria" id="AYE34486">
        <property type="protein sequence ID" value="AYE34486"/>
        <property type="gene ID" value="CP523_08640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59888">
        <property type="protein sequence ID" value="QAS59888"/>
        <property type="gene ID" value="EI377_03390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08640"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="259" mass="28346" checksum="D385F910AE8253B8" modified="2018-12-05" version="1">MVLLVDVGNTNIVLGVYKERENIVSWRISTDSKKTSDEYGIQVMQLFTQSELNPKEVKGIIISSVVPNIMHSLENMIKKSFGINPLVVGPGVKTGINIKYDNPKEVGADRIVNAVAAHDIYKKDVILIDFGTATTFCSVTKSGNYLGGCIVPGVKISSDALFDRAAKLPRVELEVPQNIICKNTISSMQAGIIYGYIGQVEYIVKKTKKEMMDLGSEEPFVIATGGLANLVANETDVIDKVDSSLTLEGLRIIYEKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN4</accession>
    <name>A0A386PIN4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08820</name>
        <name evidence="3" type="ORF">EI377_03575</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678096.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02704"/>
    <dbReference type="EnsemblBacteria" id="AYE34512">
        <property type="protein sequence ID" value="AYE34512"/>
        <property type="gene ID" value="CP523_08820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59914">
        <property type="protein sequence ID" value="QAS59914"/>
        <property type="gene ID" value="EI377_03575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="240" mass="27513" checksum="9BD96FF1AB1EE944" modified="2018-12-05" version="1">MIDKNSPIPVYYQLKNDLISKIAEGVWKPGECIASERELCEIYGVSRMTIRQAIGELVQEGILLRIKGKGTFVCEPTVKQQDMMSFTEIIKQTGRKLKTEIIEFKKVNTPENLTDTFELDELYKINRKRIVDGECIAIETVYIPVDYCGYIDENMLEGSLYKILEDFGYSVDYSTSSIASIIINEELKSLFCVKNDVPLLKVIGKTFTQSGKILFVEEAIYRSDKFLLQVNISRREGKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS5</accession>
    <name>A0A386PIS5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13215</name>
        <name evidence="2" type="ORF">EI377_08060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35307">
        <property type="protein sequence ID" value="AYE35307"/>
        <property type="gene ID" value="CP523_13215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60696">
        <property type="protein sequence ID" value="QAS60696"/>
        <property type="gene ID" value="EI377_08060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="123" mass="13475" checksum="2753B62ECB148018" modified="2018-12-05" version="1">MYFKKQTYENDMEILVTQSNLITFTSTVKSTSIKPNENGRKLVKAGTLIDAEGTVVTQTGGEGSETLTTTPAGVLYKTVDVTNGDMPCSLVVEGYLRKDRVLDGFSEKAIETIKSTLVKITFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIW4</accession>
    <name>A0A386PIW4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_12295</name>
        <name evidence="9" type="ORF">EI377_07120</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
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    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AYE35134">
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        <property type="gene ID" value="CP523_12295"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
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    <dbReference type="InterPro" id="IPR001789">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
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        <location>
            <begin position="144"/>
            <end position="209"/>
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        <location>
            <position position="56"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="212" mass="24073" checksum="A8186D20946C69FC" modified="2018-12-05" version="1">MEKIKLLIVDDEKLIREGLKVMLSIFDDIEVVGLAENGYKALEICKNTDVDIVLMDIRMKECNGVMGTRLIKEQFSKIKVIILTTFKDKEYIQEALKYGAFGYMLKDSSHDVIYEGIKTAYKGNMVVHPDVAIEMLGCSVSIKKDIDKYELLEKEINIIKLIAKGLSNKEISEKLFLSEGTIKNNITNILSKLELRDRTQIAIFAFKNGIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
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    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02189"/>
    <dbReference type="EnsemblBacteria" id="AYE34159">
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        <property type="gene ID" value="CP523_06560"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AYE34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="292" mass="33896" checksum="523C421CF20ED924" modified="2018-12-05" version="1">MIYTLENDSIKITASTFGGELNSITSKKDNTEFLWNGDAKYWKYHAPILFPIVGKVKDGKYKVDGETFELPQHGLARTREFNMIEKDENHIIFELTWSEDTLKVYPYKFSLKITYTLVDNGVVTTYTVNNIDNKTIYFSIGAHPAFMCPIDSNEKFDDYYFEFNKKETSSTMQLDPLTGYLIHDKKEYLKDTNVIPLSFEIFKKDALIFDDLKSNIITLKSKNHNKTLSMDFTGFPYMALWTKSTGAPFVCIEPWYGHSDFNDFNGELKDKPGIEKLNINEIFNSNYTIYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ51</accession>
    <name>A0A386PJ51_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11225</name>
        <name evidence="4" type="ORF">EI377_06015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677037.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00895"/>
    <dbReference type="EnsemblBacteria" id="AYE34938">
        <property type="protein sequence ID" value="AYE34938"/>
        <property type="gene ID" value="CP523_11225"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60332"/>
        <property type="gene ID" value="EI377_06015"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
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        <property type="entry name" value="HTH_RpiR"/>
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        <property type="entry name" value="RpiR-like_SIS"/>
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        <property type="entry name" value="SIS_dom"/>
    </dbReference>
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        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="111"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="265" mass="30148" checksum="7DB31D79E21B0968" modified="2018-12-05" version="1">MDVLYEIQKKYNSFSDKEKNIADYILKESETINNINITDLAKITLTSGSTITRFCKKICCDSFVDMKINLSSLKRNDELEQKGVLADVYSYYTEVIEKTRKLISKEQIKKVVNEIKKANKIYIYGVGSSGLTAKEMMQRLLRMGFNVYSISDPHMMIINSSIVSESDLVIGISISGETEEVINSLKISKKNGAKIVSITSFEDSHITEIGELNFIVYNALFVDKKRFINSQFSAMYLMDLISMLLLEDELLGQNMQRTIDAITKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJA9</accession>
    <name>A0A386PJA9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL family lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09935</name>
        <name evidence="3" type="ORF">EI377_04720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676537.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00316"/>
    <dbReference type="EnsemblBacteria" id="AYE34696">
        <property type="protein sequence ID" value="AYE34696"/>
        <property type="gene ID" value="CP523_09935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60097">
        <property type="protein sequence ID" value="QAS60097"/>
        <property type="gene ID" value="EI377_04720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="190" mass="21823" checksum="B66E38221E287ACD" modified="2018-12-05" version="1">MNNKNFIFIGDSLTFGYGIPKKENWVNKLNEYLNFNIVNKGINGNTTTDMLMRFSEDVIKNNPSNIFIMGGTNDLLSNRDIEFITKNLQLMIEESLNYGANVTIGIPPTLIPKDAYRLFSPSDTYEKTKELLPILRNKLINICINYNLKFIDFYNLSLDNLDKNIFFDGIHFNSKGQELAYAEALKVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB7</accession>
    <name>A0A386PJB7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_09995</name>
        <name evidence="4" type="ORF">EI377_04780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676554.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00328"/>
    <dbReference type="EnsemblBacteria" id="AYE34706">
        <property type="protein sequence ID" value="AYE34706"/>
        <property type="gene ID" value="CP523_09995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60107">
        <property type="protein sequence ID" value="QAS60107"/>
        <property type="gene ID" value="EI377_04780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="292" mass="33330" checksum="481493A4FCCD66D2" modified="2018-12-05" version="1">MNIDSLKYFLEVAKSKSITTVAKNSHISQSALSQQLFKLESKLNVKLLNRSNKGVSLTPEGEILFKHSKNILNIYNKMLEEIYTCALEKNYISIEAVDSLNSTILPNVICNLKSTFSQYSINLTSIENSTNSNLSNNICDIYINYEKPNSKIGLSIKDLGCDELIVISNNDFPKNKISKSELINLPIILNLKDNYFNNKIQEILLCNIKDLNIVYNTSSYLSLLKGLCCSNSISFIPRILFNSYKNEFNIKEIKIDDFNLNANLYLCYLDSFYKNHSDFIKTLINMIKGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG4</accession>
    <name>A0A386PJG4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11940</name>
        <name evidence="6" type="ORF">EI377_06760</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673457.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02946"/>
    <dbReference type="EnsemblBacteria" id="AYE35068">
        <property type="protein sequence ID" value="AYE35068"/>
        <property type="gene ID" value="CP523_11940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60461">
        <property type="protein sequence ID" value="QAS60461"/>
        <property type="gene ID" value="EI377_06760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="322" mass="36773" checksum="513334B09F3D8152" modified="2018-12-05" version="1">MIIGIGTNEAGQRLDKFLRKLLKDVPLSKIFKALRKGDIRVNGKKQKENYSLQLDDIVEIRYIQSNKEKSKPKFIKVESGGLKITYEDENLLVVEKWPGVLVHPDQKGHEATLTDYVLSYLNEKGDYLPESEVTFTPASCNRLDRNTSGIVIFGKTFEGLRELNEIIREGKVDKYYNALVKGKIKDGLYKGYILKNEEVNISKVYDDNVPNSKEIAMEVKTVQTNGAYSLLEINLITGRSHQIRAHLAQLGTPIIGDNKYGDRKLNSFFSNKFGLECQFLYAYKLIFRNTDGKLSYLKNKTIAESLPPIFKKIKKDVFKFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI1</accession>
    <name>A0A386PJI1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12050</name>
        <name evidence="4" type="ORF">EI377_06875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02967"/>
    <dbReference type="EnsemblBacteria" id="AYE35088">
        <property type="protein sequence ID" value="AYE35088"/>
        <property type="gene ID" value="CP523_12050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60481">
        <property type="protein sequence ID" value="QAS60481"/>
        <property type="gene ID" value="EI377_06875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="295" mass="33667" checksum="BE3CB5B18D8DABDD" modified="2018-12-05" version="1">MEGSLILNIEQVKYFLEVEKYKSFTLASEELCISQSSLSKQIKSLEKELNTELFIRNPRNILLSYSGEKFLEYAKSYVTLHNKILKEMMDISNRELNIGITPLLSQYGIISLINTFNKSFSKINLNLIENDSSNLFKLFNSKSINLAFTNLNDIDTENYNAISLFKDELVLVISKNNPLAKVESINICSLSKQTFILSESNNSLYNLCTKECLKSGFYPKISYSSCRIDTILELVSQGFGVTLLPQKVINKFNTENLRSIPLQNTIINEIVLTFPKNLPLSTETKLFIEFIISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP3</accession>
    <name>A0A386PJP3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10710</name>
        <name evidence="3" type="ORF">EI377_05495</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674129.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34836">
        <property type="protein sequence ID" value="AYE34836"/>
        <property type="gene ID" value="CP523_10710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60231">
        <property type="protein sequence ID" value="QAS60231"/>
        <property type="gene ID" value="EI377_05495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="116" mass="13302" checksum="43DD33DF16C92966" modified="2018-12-05" version="1">MLDKENSNINEEIINVENNEEITVEEILVENIVKKESKNMTIIKKLLVGVIDQIIIFAASLLTLIVFDFLLKLIGLFVAEREPVFLIIYALLNVIYIPICEGTRLRKTIGKKILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJT9</accession>
    <name>A0A386PJT9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">CP523_12735</name>
        <name evidence="8" type="ORF">EI377_07610</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675171.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A386PJT9"/>
    <dbReference type="STRING" id="1504.GCA_900092375_01964"/>
    <dbReference type="EnsemblBacteria" id="AYE35218">
        <property type="protein sequence ID" value="AYE35218"/>
        <property type="gene ID" value="CP523_12735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60614">
        <property type="protein sequence ID" value="QAS60614"/>
        <property type="gene ID" value="EI377_07610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12735"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="245"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="385" mass="42828" checksum="25B4701BB89BF354" modified="2018-12-05" version="1">MNLLHPFWAEINLDNFIYNLNKIKSHIGNSKLIGIVKANAYGHGAVEISKALIENGASSLAVANIVEGIELREANIDAPIMILGVSEELAIEAIINYNMEPTVSSLDFAYTLNNKAKESNKIINIHIALDTGMGRIGFLPSSKSIEEIALISKLPNLKIKSTFSHFSTSDYKDKSYSNFQLENYKNFIKELEKNNITIGDKNLSNSAAIIDMPNAHFDNVRPGIIQYGYYPSDEVIKDAFDLKPVLTWKTNIVHIKEVDKGTFIGYGKTFETKRKSIIATIPVGYADGYSRELSNKGKVIINGQFAPIIGNVCMDQCMVDITDLKDVNLNDEVILLGSDKNIKFDADDMANLLGTINYEVLCLIGRRAPRVYIKNNTVVTIKHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU5</accession>
    <name>A0A386PJU5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14495</name>
        <name evidence="7" type="ORF">EI377_09470</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676844.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02492"/>
    <dbReference type="EnsemblBacteria" id="AYE35544">
        <property type="protein sequence ID" value="AYE35544"/>
        <property type="gene ID" value="CP523_14495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60930">
        <property type="protein sequence ID" value="QAS60930"/>
        <property type="gene ID" value="EI377_09470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14495"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="325" mass="36229" checksum="48B2B340F78D86E2" modified="2018-12-05" version="1">MEDKKVLLEVKDLCKYFPANKGLLGKKSYVKAVDRVSFTINKGETLGLVGESGCGKTTTGRTVLNLYEATAGQIIFEGKDITKYSPKEMLPLRKRMQMIFQDPYASLNPRMTVGDIIGEAIDIHGIMKGKERTERIRYLLNKVGLNGDHINRYAHEFSGGQRQRIGIARALAVEPDFIVCDEPISALDVSIQAQVINMLEELQEEFGLTYLFIAHDLSMVKHISTHIGVMYLGRMVEKGPSNDVYTNPQHPYTKALLSAVPIPDPDVAKSNKRIVLEGDIPSPIDPPPGCRFKGRCRYAKPICGEVDPELKEVEPGHFVACHLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJV1</accession>
    <name>A0A386PJV1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HesB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11250</name>
        <name evidence="2" type="ORF">EI377_06060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673226.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02807"/>
    <dbReference type="EnsemblBacteria" id="AYE34942">
        <property type="protein sequence ID" value="AYE34942"/>
        <property type="gene ID" value="CP523_11250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60336">
        <property type="protein sequence ID" value="QAS60336"/>
        <property type="gene ID" value="EI377_06060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010965">
        <property type="entry name" value="HesB-rel_seleno"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01911">
        <property type="entry name" value="HesB_rel_seleno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="110" mass="12038" checksum="DC9B84062FEA6D4E" modified="2018-12-05" version="1">MDKIIISEEAYKEFKAFLDENEIEKYSIRINLAGFGCSGPAFNITVDEAKEGDVTHQVHDITFIVEEKLVDEFGGFKLLSTEENEGRGLSLKPVIEVEGGCGSCGGGCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK29</accession>
    <name>A0A386PK29_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor P</fullName>
            <shortName evidence="8">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">efp</name>
        <name evidence="12" type="ORF">CP523_15000</name>
        <name evidence="13" type="ORF">EI377_09955</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021875815.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01284"/>
    <dbReference type="EnsemblBacteria" id="AYE35634">
        <property type="protein sequence ID" value="AYE35634"/>
        <property type="gene ID" value="CP523_15000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61021">
        <property type="protein sequence ID" value="QAS61021"/>
        <property type="gene ID" value="EI377_09955"/>
    </dbReference>
    <dbReference type="GeneID" id="66301828"/>
    <dbReference type="KEGG" id="csep:CP523_15000"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="11">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="10">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="20814" checksum="E4E3A6B259B6F008" modified="2018-12-05" version="1">MISAGDLRKGTTFEHEGQVYTVIDFLHVKPGKGAAFVRTKLRNVISGGVTDTTFNPTAKLQEAVIERKEMQYLYSDGELYYFMDQETFEQIPLNYEKVEDAIKFLKENMFAIIKFYKGEAFSVEAPNFVELLITQADPGIKGNTATNAMKPATLETGAVVNVPMFVNEGDTIRVDTRTGEYMERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK68</accession>
    <name>A0A386PK68_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35674">
        <property type="protein sequence ID" value="AYE35674"/>
        <property type="gene ID" value="CP523_15230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="79" mass="9484" checksum="8BA3C684D2880B28" modified="2018-12-05" version="1">MKREEAIIKLKDLLYNFKEFTSIETMEEDVQALEYAIKELERTVQEQYVTLKIDSTEIARVVIDEINRQQKRSHRILIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK93</accession>
    <name>A0A386PK93_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_15275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35681">
        <property type="protein sequence ID" value="AYE35681"/>
        <property type="gene ID" value="CP523_15275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="204" mass="24461" checksum="71F20C8B85DA05B4" modified="2018-12-05" version="1">MIFGYVRVSSKEQNENRQVKALKDFCNELKYENIYIDKESGKDFNREKYQELKKILRKGDTLIVKELDRFGRNKEDVKNELDYYKEKKIRVKILNIPTTLMDFPEGSEWVFEMINNILIEVLGAIAEEERNKIRSRQREGIEIAKKEGKYKGRPKSELPQGFEKLYRQWKDNNITAIQFTKLLGLKSRTTLYKYIKRYEEIKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKH4</accession>
    <name>A0A386PKH4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12405</name>
        <name evidence="3" type="ORF">EI377_07290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675345.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02032"/>
    <dbReference type="EnsemblBacteria" id="AYE35156">
        <property type="protein sequence ID" value="AYE35156"/>
        <property type="gene ID" value="CP523_12405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60559">
        <property type="protein sequence ID" value="QAS60559"/>
        <property type="gene ID" value="EI377_07290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="364" mass="37994" checksum="7D397D590C31EAB7" modified="2018-12-05" version="1">MCEVSKGVSTEALVAKKKLASNFFKKGISLALFSGLAYGLYTAFLTMGMTKGVWGDWYGVNTAGLSAFVIAYLLAALGNAINDTCSAIWALGYAVVKGKFGDFLRCINTSPGRIMIIAALIGGPIAGTAYVIALQMAGSIVVPISALCPAIAAILGRVLYKQELNKRMAFGIGICVFASFLIGSTGFSGGASASTFIGIAIACIAALGWGFEGCVAGYGTAMIDPEIGICIRQVTSGIANLFILVPIFGIMAGGVNISVDLAVQAFTSAPAMFWFVLSGLLSFITFMTWYAGNSMCGAGLGTACNGTYSFFGPLFCLLLLGVYGGMDGWSLPSVAWIGAIVMMFGILTISMNPLDLFRRKKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKK4</accession>
    <name>A0A386PKK4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ORF">CP523_14195</name>
        <name evidence="11" type="ORF">EI377_09100</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678515.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00283"/>
    <dbReference type="EnsemblBacteria" id="AYE35488">
        <property type="protein sequence ID" value="AYE35488"/>
        <property type="gene ID" value="CP523_14195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60874">
        <property type="protein sequence ID" value="QAS60874"/>
        <property type="gene ID" value="EI377_09100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="422" mass="44914" checksum="C84A406D3290F86C" modified="2018-12-05" version="1">MKAKGKGKGKSLIIFLLCVIAIFSLAFAGFKGFKIAGWEFKSFDKVITKGLDLQGGVSVLMEIQDENSSRDDLEKTRQLLELRVNKLGVAETTVATEGEKRIRVDIPGKFDSNEIVDSLGKTGNLTFKDPSGNVVLTGKDVKEATAMLDHQTNKPVVSLKLNEEGQKKFADATSKNIGKQISISMDEEVISSPTVQNAITDGNAIITGSSTIDEAKNLSGLINSGALPVSIKAVSVNNVGAQLGSEALPNAMKAGVVGIALIFIFMIIYYRVPGILSCIALVLYTTLVLLIFAEVGATLTLPGIAGFLLTIGMAVDANVLIFERIREELAKGISIKSAVKKGFENALSSIVDSNVTTIIAALVLYFIGSGAVKGFAVTLMIGILVSMFTALIVTKLLVNLSVEIGLLKDIRQFRVKRGAKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKM2</accession>
    <name>A0A386PKM2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YceG_bac domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05350</name>
        <name evidence="3" type="ORF">EI377_15915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02598"/>
    <dbReference type="EnsemblBacteria" id="AYE35824">
        <property type="protein sequence ID" value="AYE35824"/>
        <property type="gene ID" value="CP523_05350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62093">
        <property type="protein sequence ID" value="QAS62093"/>
        <property type="gene ID" value="EI377_15915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025647">
        <property type="entry name" value="YceG_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14266">
        <property type="entry name" value="YceG_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceG_bac" evidence="1">
        <location>
            <begin position="28"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="514" mass="60308" checksum="FBC4F9ED06DB7BE4" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKN1</accession>
    <name>A0A386PKN1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_12725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675180.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01966"/>
    <dbReference type="EnsemblBacteria" id="AYE35216">
        <property type="protein sequence ID" value="AYE35216"/>
        <property type="gene ID" value="CP523_12725"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="87"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="660" mass="74029" checksum="2ABC77E8635F5E34" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKN5</accession>
    <name>A0A386PKN5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadD</name>
        <name evidence="8" type="ORF">CP523_10675</name>
        <name evidence="9" type="ORF">EI377_05460</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674143.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01367"/>
    <dbReference type="EnsemblBacteria" id="AYE34829">
        <property type="protein sequence ID" value="AYE34829"/>
        <property type="gene ID" value="CP523_10675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60224">
        <property type="protein sequence ID" value="QAS60224"/>
        <property type="gene ID" value="EI377_05460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10675"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="199" mass="23395" checksum="DA1814EA4D78E4A2" modified="2018-12-05" version="1">MKRIGIIGGTFNPIHLAHLYIAYEAKHQLNLDKVIFMPAGSPPHKDTNGILMAPLRYDMVKLAIASYKDFQISDYEIKKQGYSYTFETLQYLSSPDNRLFFITGADCLMDIEKWKEPEKIFLNCKFIVFNRSGYNKKLLLEQKNKIEKKYDTKISFLDTIDLEISSSMIRQRIKEDKRVDFFLPKEVLDFIKRNQLYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKR4</accession>
    <name>A0A386PKR4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="10" type="ORF">CP523_14640</name>
        <name evidence="11" type="ORF">EI377_09605</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678864.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00146"/>
    <dbReference type="EnsemblBacteria" id="AYE35568">
        <property type="protein sequence ID" value="AYE35568"/>
        <property type="gene ID" value="CP523_14640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60954">
        <property type="protein sequence ID" value="QAS60954"/>
        <property type="gene ID" value="EI377_09605"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="710"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="502"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="332"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="785" mass="88476" checksum="F38310967B5B93A8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKR5</accession>
    <name>A0A386PKR5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>unnamed1</name>
    </geneLocation>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
            <plasmid evidence="4">unnamed1</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023672">
        <property type="protein sequence ID" value="AYE35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35901">
        <property type="protein sequence ID" value="AYE35901"/>
        <property type="gene ID" value="CP523_15820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Plasmid unnamed1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="51"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="221" mass="25343" checksum="9A0D12218D1A5A48" modified="2018-12-05" version="1">MNIISTAIFGAIPFYISAIPIILLNMLLISEKRALLNIRFELKEKIAILGFILSIIFVLGITIGNNSSASFDMVRLRSINIIPFKGMNVQYLFALKGDMYSIVNLFGNILIFIPFGFFLSIYYKDDAKERFKIIITAMIISFFIEFLQLFIGRAVDINDIILNTTGVLLGRIIFRYFNIIFGNILNTINLRYINISNNKGVNRIRVLQLFLLITFLIFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKT3</accession>
    <name>A0A386PKT3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11030</name>
        <name evidence="3" type="ORF">EI377_05825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677109.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00933"/>
    <dbReference type="EnsemblBacteria" id="AYE34899">
        <property type="protein sequence ID" value="AYE34899"/>
        <property type="gene ID" value="CP523_11030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60294">
        <property type="protein sequence ID" value="QAS60294"/>
        <property type="gene ID" value="EI377_05825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006423">
        <property type="entry name" value="Lipo_e_P4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01125">
        <property type="entry name" value="C1.1:_Acid_Phosphatase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="312" mass="35770" checksum="4F1EDE6730A96638" modified="2018-12-05" version="1">MLKKYGNVFKFLFATFLIISISAFGIGCRTKLSYEKEKIIGTEDSITNDWRKESYINGILYQLSAEVKGLQYQSYKLATVQLDKRIAERESGMYKKPLAIISDIDDTLASDCNYIAGIILQDEKWDNGPWNGYYDSIASTSNVAIPGAVEFMNYASKNGIEIFYVTNREHTQLNLSVAQLQHLGFPNADKEHVKVCDESGSSDKTERRENILKDYDVVMYLGDNIGDFTEDFSKELGTINRNELASDPKYKDLWGDKYILLPNSTYGNYVESVWNNKKGLTEDEKVQAIKEILDNYSYKNTDKFEQWYKSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKX5</accession>
    <name>A0A386PKX5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Potassium transporter TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13420</name>
        <name evidence="4" type="ORF">EI377_08315</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677553.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35346">
        <property type="protein sequence ID" value="AYE35346"/>
        <property type="gene ID" value="CP523_13420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60737">
        <property type="protein sequence ID" value="QAS60737"/>
        <property type="gene ID" value="EI377_08315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="23436" checksum="30BC0D30CD7244D6" modified="2018-12-05" version="1">MSKQTKTPNYIKIAVDIAHRIVNNDFVEGSKITGRTTLVSLYNVSPETIRRSLALLKDMDVVTVNEKSGIIINNKSHAKEFLNKFKTKSDFTTLNNETFDLIKQRKDLDSKLIKNLNSIIEFATQLRNVGSIIPFESIVEEGSIAVNKSIGELNFWHNTKATIIAVKRNGDLFLSPGPYFKIQNDDILVYVGEDEVLENVKNYISAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL55</accession>
    <name>A0A386PL55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14030</name>
        <name evidence="2" type="ORF">EI377_08935</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678647.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35456">
        <property type="protein sequence ID" value="AYE35456"/>
        <property type="gene ID" value="CP523_14030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60844">
        <property type="protein sequence ID" value="QAS60844"/>
        <property type="gene ID" value="EI377_08935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="153" mass="17806" checksum="24281C54F0E840CD" modified="2018-12-05" version="1">MVVSEVNQIILNIRRGNYRYIGSGSSRQVFDLRNGYVIKVARNKAGTAQNRAEYIISSSDYSELFAKVIYASDNFYFIIMEKANTVNTFSWVLKYFNASCNKDLVNSTKLQYIHQKYNLLWADLFKKSSWGVINGRPVIIDYGFTRMVAKRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL87</accession>
    <name>A0A386PL87_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="9">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hisS</name>
        <name evidence="11" type="ORF">CP523_14235</name>
        <name evidence="12" type="ORF">EI377_09140</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678495.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00275"/>
    <dbReference type="EnsemblBacteria" id="AYE35496">
        <property type="protein sequence ID" value="AYE35496"/>
        <property type="gene ID" value="CP523_14235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60882">
        <property type="protein sequence ID" value="QAS60882"/>
        <property type="gene ID" value="EI377_09140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="415" mass="47560" checksum="617E7F95F2D6D7BD" modified="2018-12-05" version="1">MEIKAPKGTKDMLPQDAYKWHFVEETFKNTAKFYGMREIRTPIFEHTELFLRGVGDTTDIVQKEMYTFNDKGNRSITLKPEGTAPIVRAFIENRLFNEAQPTKLYYSIPCFRYENVQKGRLRQFHQVGTEVFGSKEPSMDAEVIAFAMNVLKNLGLNSLSLNINNLGCPKCRPNYNEALKKYLKENYDSLCPLCKTRFEKNPMRILDCKEKKCNEITKNAPIILDYMCEECNTHFTDVKKYLDALEVSYTVDPGIVRGLDYYTKTIFEILNDDFTVCGGGRYDRLIEELGGPEMPSVGFAMGVERLIMTLENEGIDIPNENLFDLYIGARGDEAKLAAFTIANKLRNFNIKTEVNHMGRSVKAEMKYANKIGALFTTILGEDELQNKTIKLKRMSDGEQFEVDLDNIEEIAKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLD0</accession>
    <name>A0A386PLD0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltX</name>
        <name evidence="12" type="ORF">CP523_12790</name>
        <name evidence="13" type="ORF">EI377_07665</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678206.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02795"/>
    <dbReference type="EnsemblBacteria" id="AYE35868">
        <property type="protein sequence ID" value="AYE35868"/>
        <property type="gene ID" value="CP523_12790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62178">
        <property type="protein sequence ID" value="QAS62178"/>
        <property type="gene ID" value="EI377_07665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="35"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="512"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="293"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS62178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="553" mass="63543" checksum="4D01AF48821A9C93" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLS2</accession>
    <name>A0A386PLS2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14470</name>
        <name evidence="3" type="ORF">EI377_09445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676851.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02487"/>
    <dbReference type="EnsemblBacteria" id="AYE35882">
        <property type="protein sequence ID" value="AYE35882"/>
        <property type="gene ID" value="CP523_14470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62195">
        <property type="protein sequence ID" value="QAS62195"/>
        <property type="gene ID" value="EI377_09445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="39"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="242" mass="28123" checksum="EDFC6DC01CC1C77E" modified="2018-12-05" version="1">MGLLVVSMITSIFFRNNEKLVFSYMTKEQPIFRVDREDKAISITFDVNWAEEEHLIDILNVLDKYNVKATFFIMGKWVNYPEGNKEKLIKIKEGGHEIGNHSYVHPMFSKINDGRIKEELEKTDKIVEGTVGVKPKVFRFPSGDFNEKAYNTVSSLGYVPIQWDVDSVDWKESGAEIEYNRVMKKVKPGSIILFHNNAKYTSDNLDRIIPELQKAGYTFMPVGELIYNEDYYINEQGEQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLS7</accession>
    <name>A0A386PLS7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03132"/>
    <dbReference type="EnsemblBacteria" id="AYE35892">
        <property type="protein sequence ID" value="AYE35892"/>
        <property type="gene ID" value="CP523_15200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15200"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIDA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="263" mass="28515" checksum="AD8D64F15E7718FB" modified="2018-12-05" version="1">MKVIVVGGGWAGCAAAITAKKAGADVYLYEKTDLLLGLGNVGGIMRNNGRWTASEELKELGAGDLIDVIDNSARHKNIDFPGHKHATLYDVNIIEGNVREYIEEMGIKVFTENRVTDVEVENKKIKGIYLSDGSYIKGDVFIETTGTTGPMGNCLRYGNGCSMCVLRCPAFGPRLSISERCGVSDIQGERDDDILGAFSGSCKLAKESLSPEILDELNSTGKVILQVPREDVNYGKLSTKVCQQYALKEFAENIILLDTGHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLY9</accession>
    <name>A0A386PLY9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS glucose transporter subunit IICBA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CP523_10460</name>
        <name evidence="17" type="ORF">EI377_05235</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674342.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01408"/>
    <dbReference type="EnsemblBacteria" id="AYE35856">
        <property type="protein sequence ID" value="AYE35856"/>
        <property type="gene ID" value="CP523_10460"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62163">
        <property type="protein sequence ID" value="QAS62163"/>
        <property type="gene ID" value="EI377_05235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005355">
        <property type="term" value="F:glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011299">
        <property type="entry name" value="PTS_IIBC_glc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02002">
        <property type="entry name" value="PTS-II-BC-glcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="2"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="424"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="541"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE35856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS62163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="676" mass="74289" checksum="D4AB08A590C0C033" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM48</accession>
    <name>A0A386PM48_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsid protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">CP523_15315</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03085"/>
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        <property type="gene ID" value="CP523_15315"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="302" mass="33849" checksum="A682E04589FDD23E" modified="2018-12-05" version="1">MMAVNYAQQYSKELANAYPYVLYSGRLWSTENDKKYKVVDAKTIKIPKLSTTGRVNGDRSKIGDFSQNFSNDWETKELKNHRIWQTLVHPQDVNQTNQVASITNITQTMNETQKFPELDAMMFSTLYKLKNEKKAIVQEKTDLDSKSALVKFDAMMDEMDEGLVPATGRVLYVDTFTKTLLDNAVAIVRTNGDKTLTRTVSRLDEVDIVGVPTALMKTAYTFNDGKTGGQESGGITAKGEAKNMAMILVHPSAILPIVSYSFAQLQSPSALSQGKYVYFEESFEDVFILEERAAAIQICIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMB7</accession>
    <name>A0A386PMB7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35819">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="105" mass="12400" checksum="6FF26EFDFF7A53D9" modified="2018-12-05" version="1">METLGEKLAYLRKKAGVTQRELMDTLQFENLHKYEKDKREPNIEILSKLSKYFNVSSDWLLGLDTANFDLSEEEINFITNFRKLPEKEKLKIEGMVELKLAEMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAX0</accession>
    <name>A0A386PAX0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">CP523_00710</name>
        <name evidence="12" type="ORF">EI377_11200</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676394.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00673"/>
    <dbReference type="EnsemblBacteria" id="AYE33075">
        <property type="protein sequence ID" value="AYE33075"/>
        <property type="gene ID" value="CP523_00710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61244">
        <property type="protein sequence ID" value="QAS61244"/>
        <property type="gene ID" value="EI377_11200"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00710"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="261"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="386" mass="43134" checksum="D60BA203FF4200C3" modified="2018-12-05" version="1">MKNISILGATGSIGTQTLDVIRESNGDIKLIGVTANSSVDKMKEIIEEFKPKYVAMMDKASAKKIKEYTLKNFLDIIVLEGMEGLEEIASLEEIDMVVTSVVGMIGLKPTIKAIEARKDIALANKETLVVAGEIVMKKAKEMGVEILPVDSEHSAIFQALSGYTEKDINKIILTASGGPFRGKKIDDLKNVTVNDALKHPKWNMGKKISIDSATLMNKGLEVIEAHFLFNCPYENIEVVVHKQSIIHSMVEYKDASIIAQLGSADMRLPIQYAINKRERKAQIAKTISFSKIKELTFEEPDIETFKCLKLAYEAGKEGGLATTILNGANEEAVALLLEEKIQFLQIADIIEECMQYFEKEKYKELNLDNIIILDKKVREYIRGKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB08</accession>
    <name>A0A386PB08_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF177 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00855</name>
        <name evidence="2" type="ORF">EI377_11350</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674574.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02348"/>
    <dbReference type="EnsemblBacteria" id="AYE33103">
        <property type="protein sequence ID" value="AYE33103"/>
        <property type="gene ID" value="CP523_00855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61273">
        <property type="protein sequence ID" value="QAS61273"/>
        <property type="gene ID" value="EI377_11350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="170" mass="19455" checksum="46D4F13FD4FF2EA5" modified="2018-12-05" version="1">MIIQFSDLISQKNRKKEINVTYDLSPVYYDGDKIQAVEAVNVEGEVRAFEDILVFKASIKTKLELHCSRCLEAFIYPIDIDIEERFTNNSELLEEDEEVVFVEGDSIDITEIVENIIISTLPIKRLCVDNCKGLCHQCGKNLNIDTCQCETNDVDLRMAKLQELFGNKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBA7</accession>
    <name>A0A386PBA7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01390</name>
        <name evidence="3" type="ORF">EI377_11905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675585.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33205">
        <property type="protein sequence ID" value="AYE33205"/>
        <property type="gene ID" value="CP523_01390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61377">
        <property type="protein sequence ID" value="QAS61377"/>
        <property type="gene ID" value="EI377_11905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="19061" checksum="83FAEAB86DEF8D49" modified="2018-12-05" version="1">MIETTKRNRTISLIKMAVMAALVCFATFSFKVPTLNGYTHLGDSMIFISVVLLGGRKGAFAGAMGAALADLIGGYMIWIIPTFIIKYAMAVIMSFFIMKFKNEKSYNWIIGAVLGAIVQIMGYTFTNYILFGLSYAVAEFWGLIVQSIAGLICAIVIITMLVKSNLLNRLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC00</accession>
    <name>A0A386PC00_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">infB</name>
        <name evidence="12" type="ORF">CP523_00670</name>
        <name evidence="13" type="ORF">EI377_11160</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676377.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00665"/>
    <dbReference type="EnsemblBacteria" id="AYE33067">
        <property type="protein sequence ID" value="AYE33067"/>
        <property type="gene ID" value="CP523_00670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61236">
        <property type="protein sequence ID" value="QAS61236"/>
        <property type="gene ID" value="EI377_11160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="182"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="8">
        <location>
            <begin position="185"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="191"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="683" mass="74467" checksum="63427011CE634237" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC37</accession>
    <name>A0A386PC37_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ORF">CP523_02065</name>
        <name evidence="6" type="ORF">EI377_12585</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678867.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00119"/>
    <dbReference type="EnsemblBacteria" id="AYE33330">
        <property type="protein sequence ID" value="AYE33330"/>
        <property type="gene ID" value="CP523_02065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61500">
        <property type="protein sequence ID" value="QAS61500"/>
        <property type="gene ID" value="EI377_12585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="15477" checksum="64A32BFE012300D6" modified="2018-12-05" version="1">MERSLVLIKPDAVERNLIGKIISFYENDGLKITALKMESISKDLASKHYYEHKEKDFYEGLIDYITRSPLCALVIEGEDAISRIRKINGSTNPEKAGDGTIRKLFGINGRENCVHASDSIESAKREINLWFPKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC64</accession>
    <name>A0A386PC64_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="15">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CP523_03160</name>
        <name evidence="18" type="ORF">EI377_13675</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 15">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 13">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="15"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677270.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02151"/>
    <dbReference type="EnsemblBacteria" id="AYE33535">
        <property type="protein sequence ID" value="AYE33535"/>
        <property type="gene ID" value="CP523_03160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61698">
        <property type="protein sequence ID" value="QAS61698"/>
        <property type="gene ID" value="EI377_13675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03160"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 15 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15 17" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS61698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="37957" checksum="E332D16D8B53C380" modified="2018-12-05" version="1">MEKNVDIDWNNLGFSYIKTDYRYVSIWKDGKWDEGKLVEDNMLTISEASTALHYGQQCFEGLKAYRRKDGKVQLFRVDRNAERLNVSNKRLLMPEVPVEKFIDACKQVVKANEHFVPPYGTGATLYLRPFMIGVGNNIGVKPAPEYIFCVFAVPVGPYFKEGLAPCNFMIADYDRAAPLGTGGQKVGGNYAASLHPHQIAADRGFADCIYLDPATHTKIEEVGAANFFGITKNNEFVTPNSPSILPSITKYSLMDIAKNYLNMPVFERDVLIDNLDEFKEAGACGTAAVITPIGGIEYKNNLHVFYSETEVGPTTKELYRILCGIQFGDIEAPEGWIFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCD2</accession>
    <name>A0A386PCD2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ORF">CP523_01030</name>
        <name evidence="4" type="ORF">EI377_11525</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674495.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02313"/>
    <dbReference type="EnsemblBacteria" id="AYE33137">
        <property type="protein sequence ID" value="AYE33137"/>
        <property type="gene ID" value="CP523_01030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61307">
        <property type="protein sequence ID" value="QAS61307"/>
        <property type="gene ID" value="EI377_11525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="122"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="24986" checksum="EE91EF47E743AA90" modified="2018-12-05" version="1">MMRELLSNKIKVLNSDLIEMASLVEKQIYDSIIAFKNQDADLASTVIKNDDKVDELQKDIEEKCIKFMATESPLAGDLRKIYTTSKIVTDLERMADHAVDLSKIVERIKEENLVNEISPVWEMGDLVIKMIKASIEAYIDGDIQSAYEICNMDDKVDEIYQGMFKIILKKMSKDESIINQGTQILFASKYIERIGDHVTNVCEWIIFSEKGNYVDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCP1</accession>
    <name>A0A386PCP1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_04175</name>
        <name evidence="7" type="ORF">EI377_14700</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676858.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02750"/>
    <dbReference type="EnsemblBacteria" id="AYE33725">
        <property type="protein sequence ID" value="AYE33725"/>
        <property type="gene ID" value="CP523_04175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61882">
        <property type="protein sequence ID" value="QAS61882"/>
        <property type="gene ID" value="EI377_14700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008953">
        <property type="entry name" value="Fe_hydrogenase_HydB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48674">
        <property type="entry name" value="SSF48674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="521" mass="57677" checksum="04017A84E4DADAE3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCP2</accession>
    <name>A0A386PCP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2871 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03235</name>
        <name evidence="3" type="ORF">EI377_13750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677240.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33550">
        <property type="protein sequence ID" value="AYE33550"/>
        <property type="gene ID" value="CP523_03235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61713">
        <property type="protein sequence ID" value="QAS61713"/>
        <property type="gene ID" value="EI377_13750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021299">
        <property type="entry name" value="DUF2871"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11070">
        <property type="entry name" value="DUF2871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="133" mass="15081" checksum="51C17C760B798AAC" modified="2018-12-05" version="1">MKKYLNLSTFYLILGLAFGVFYREFTKMNSFEGVTVLDGIHSHILILGFIFFLVILLLEKSFKISSVKSFNKWLIFYNVSFIYMIISLTIRGIMQVNGSDFAGLSHIAGLSHVMLGGALIWFIVIANKALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCQ7</accession>
    <name>A0A386PCQ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PadR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04330</name>
        <name evidence="3" type="ORF">EI377_14865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00412"/>
    <dbReference type="EnsemblBacteria" id="AYE33753">
        <property type="protein sequence ID" value="AYE33753"/>
        <property type="gene ID" value="CP523_04330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61910">
        <property type="protein sequence ID" value="QAS61910"/>
        <property type="gene ID" value="EI377_14865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="113" mass="13313" checksum="2A4568E12D345A9C" modified="2018-12-05" version="1">MKINKELLKGSTTILILSLLNRKDMYGYEMIKEMEIRSKGIFAFKEGTLYPILHALENENFIESYWDSGEGRRKRKYYKITDDGKNILKEKQEDWELFSSTVNHVLKEGALCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCX4</accession>
    <name>A0A386PCX4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="9">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="9">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">fabZ</name>
        <name evidence="10" type="ORF">CP523_01230</name>
        <name evidence="11" type="ORF">EI377_11730</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674366.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02272"/>
    <dbReference type="EnsemblBacteria" id="AYE33174">
        <property type="protein sequence ID" value="AYE33174"/>
        <property type="gene ID" value="CP523_01230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61344">
        <property type="protein sequence ID" value="QAS61344"/>
        <property type="gene ID" value="EI377_11730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="140" mass="15358" checksum="7ADD42378763B7C7" modified="2018-12-05" version="1">MLGPKEIKEIIPHRYPFLLLDRVEEIVDGISAKGYKNVSINEPFFQGHYPDYPVMPGVLILEAMAQLGAVAVLSKEENKGKIPLFAGTNKVRWKKQVVPGDKLDLYVEIIKLKGPIGIGKGIATVDGVKTCEAELLFAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD08</accession>
    <name>A0A386PD08_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">CP523_04975</name>
        <name evidence="11" type="ORF">EI377_15475</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675718.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01682"/>
    <dbReference type="EnsemblBacteria" id="AYE33873">
        <property type="protein sequence ID" value="AYE33873"/>
        <property type="gene ID" value="CP523_04975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62015">
        <property type="protein sequence ID" value="QAS62015"/>
        <property type="gene ID" value="EI377_15475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04975"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS62015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="332" mass="36886" checksum="9903C55A9EA37B22" modified="2018-12-05" version="1">MAILVSGGMGYIGSHTTIELLNEGHKVIIVDNLYNSNIMVKDKIKEITGKEPKFYKIDLLNEDDVEVVFKENNIDAVIHFAALKAVGESVSMPLEYYNNNLTSTLVLLKLMKKYDVKNFVFSSSATVYGESEIIPIPENAPLSATNPYGRTKLMVEDILRDLYKADNSFNIAILRYFNPVGAHKSGLIGEDPKGIPNNLMPYITKVAVGELKELNIFGDDYDTVDGTGVRDYIHVVDLAKGHLKALEKLNENPGLVTYNLGTGKGYSVLELVKAFSEASGVEIPYKIVGRRPGDIATCYANPSKANRELNWVAEKGIKEICEDSWRWQSKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD12</accession>
    <name>A0A386PD12_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipid hydroperoxide peroxidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Thiol peroxidase</fullName>
            <ecNumber evidence="6">1.11.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02255</name>
        <name evidence="6" type="ORF">EI377_12775</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674019.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00516"/>
    <dbReference type="EnsemblBacteria" id="AYE33367">
        <property type="protein sequence ID" value="AYE33367"/>
        <property type="gene ID" value="CP523_02255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61537">
        <property type="protein sequence ID" value="QAS61537"/>
        <property type="gene ID" value="EI377_12775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="18268" checksum="07DE2860AF4C716D" modified="2018-12-05" version="1">MKKVTFQGDPLTLQGSTVKVGEKLRDFVVVGNDLNPVTLKDTRGVRVFLSVPSIDTGVCDMEVRKFNEEVAKLQGVTCYTVSMDLPFAQVRWCGAAGVEVVKTVSDYKDRSFGEATGTYIKELGLLTRASFVVDSQDNVTFVEYLEEITNEPSYNKVLEAVKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD39</accession>
    <name>A0A386PD39_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pssA</name>
        <name evidence="9" type="ORF">CP523_04095</name>
        <name evidence="10" type="ORF">EI377_14615</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676894.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02766"/>
    <dbReference type="EnsemblBacteria" id="AYE33710">
        <property type="protein sequence ID" value="AYE33710"/>
        <property type="gene ID" value="CP523_04095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61865">
        <property type="protein sequence ID" value="QAS61865"/>
        <property type="gene ID" value="EI377_14615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="18949" checksum="780E397E4F95337F" modified="2018-12-05" version="1">MRKSCIPNLFTFINLSCGIISILCTFDKNYLLACVFILVAGLVDRYDGRVARWLDVSSDLGKELDSLADLVSFGVAPSILVFILYNLREVGPGGIIGLVVLLTFPICGAFRLARYNATDFDGSFRGVPITIAGAFMALFVLLTLNFSISVWILIALMLSGSYLMVSTFEIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD72</accession>
    <name>A0A386PD72_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook-length control protein FliK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02590</name>
        <name evidence="4" type="ORF">EI377_13125</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673917.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00449"/>
    <dbReference type="EnsemblBacteria" id="AYE33427">
        <property type="protein sequence ID" value="AYE33427"/>
        <property type="gene ID" value="CP523_02590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61601">
        <property type="protein sequence ID" value="QAS61601"/>
        <property type="gene ID" value="EI377_13125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="343"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="472" mass="53907" checksum="329D024FA2B6EF05" modified="2018-12-05" version="1">MIDTNAFINFKTNEVDVKKISTRKDSFSRKRDFKETLNNEVGTKLKSNVNLDNNKEPIKNEVVTVKETTKKIEKAFEELKDFQGNKEDTDCLENITLLLGELMQSKEFQDVTLDNPEIKDEINLILKDILKSDENSVLGKDVLRLDLEEFRSKQDILNEAVNLTNNILEMINSNDFKKVLSDEDSKKLNAILEMLNEKLFSEDANNLNLANEIKNEENSIISKKHLKDFDSKLEKSDEEVNSVNNKSQNNTSINKFNKSDLEKEASKDNANFGETLKKEVIDSKSNSKSLSKEDKILSKILNDDKNLGLNKLLNNRFSLNDLEIIKEPAVVNKQTMDLDIIKNVKFMVKNAMSELKVKIYPKELGEMTIKILSEEGIMKAEIKATSKETYNLLNSNINDIKKGLEQQNIKIHDVNIGLYQEDATFYNGENFSNSQNQNKSKRSKSNLSEITSLDSVQDDEIVKDDNNVNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDE7</accession>
    <name>A0A386PDE7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA 2-thiocytidine biosynthesis protein TtcA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">tRNA 2-thiocytidine(32) synthetase TtcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03015</name>
        <name evidence="4" type="ORF">EI377_13515</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678442.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01774"/>
    <dbReference type="EnsemblBacteria" id="AYE33507">
        <property type="protein sequence ID" value="AYE33507"/>
        <property type="gene ID" value="CP523_03015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61673">
        <property type="protein sequence ID" value="QAS61673"/>
        <property type="gene ID" value="EI377_13515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="55"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="288" mass="33247" checksum="BCCD0813182B3AF7" modified="2018-12-05" version="1">MSSISGKGCERMIPTEEKKSLEEIERSIVKKYRKHIWSKFIKAVKDYKLVEDGDKIAVAISGGKDSLLMAKCFQELKRHGQMNFELEFIAMDPGYHPQIKELLIENCEHLGIPVYIYEGGIFEVVDKMAKDYPCYLCARMRRGSLYSKAKELGCNKLALGHHYNDVIETTLLNVLYAGNFKTMLPKFKSSNFKNMELIRPLYYVEEDYIKRFTNYAGIWPLNCACMVAAEKIGNKRYEIKDLIKELKKNFDGVEKSIFKSAENVSMDAILGWEKGGKKTKYLDVYDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDJ5</accession>
    <name>A0A386PDJ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34075">
        <property type="protein sequence ID" value="AYE34075"/>
        <property type="gene ID" value="CP523_06115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="85" mass="10352" checksum="91274F14B5778AA1" modified="2018-12-05" version="1">MFKEIIKYLKKKLRSLLVIHNIYCFYKKKMKYGEKYVENVKSYPQNVDNFEKLLTTFKKGIDTTYKGGMCVCNYIVTFDEIYRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDT1</accession>
    <name>A0A386PDT1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucokinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05405</name>
        <name evidence="2" type="ORF">EI377_15965</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02588"/>
    <dbReference type="EnsemblBacteria" id="AYE33950">
        <property type="protein sequence ID" value="AYE33950"/>
        <property type="gene ID" value="CP523_05405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62101">
        <property type="protein sequence ID" value="QAS62101"/>
        <property type="gene ID" value="EI377_15965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="318" mass="33358" checksum="FABB937A4B676185" modified="2018-12-05" version="1">MDKNFVVAVDLGGTKIYTALVDLEGNIVKEKVVKTEAEKGDLAIVSNIKSTIDFVLDGIDMKNVKAIGIGSPGPLDVKKGLIVAPPNLPFKNFNIVENLNDKYGIPVFLDNDANAATLAEFMFGVGKGTENMVYVTVSTGIGGGAILNGKIYRGSTSNAVEVGHTTVKGDGPRCGCGNKGCGERMASGTAIMKRAEEAVNSNVETSLKKYEKVTAKEVFEEAKNGDIVSQDILDEALSYLGIIVANVANTFDPDMIVLGGGVISAGEVVMEAVKKVVKARCLGIVAENCKIERSNLEGKSGVLGAAALAISEVNKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDW5</accession>
    <name>A0A386PDW5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-binding oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03825</name>
        <name evidence="6" type="ORF">EI377_14360</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675484.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01537"/>
    <dbReference type="EnsemblBacteria" id="AYE33657">
        <property type="protein sequence ID" value="AYE33657"/>
        <property type="gene ID" value="CP523_03825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61819">
        <property type="protein sequence ID" value="QAS61819"/>
        <property type="gene ID" value="EI377_14360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="295" mass="32504" checksum="314302DD6F3204BE" modified="2018-12-05" version="1">MYKIVGKRELTNNIFLMDIEAPRVAKSAQPGQFIIIKNDEKGERIPLTIADYNREQGTVTIVFQTVGEGTKQLATFNEGDYVSDFVGPLGQPSELVHEDLEELKKKNTIFVAGGVGAAPVYPQVKWMHEHGIKCDVIVGSRNKELLILEDEMKKVAGNLYVATDDGSYGFNGRVTDCLKDLVEKGNKYDHAVVIGPMIMMKFMCVLTKELEIPTTVSLNPIMVDGTGMCGACRVTVGGEVKFACVDGPEFDGHLVDFDESMRRQTMYKTEEGRAKLKQEEGDTHSHGGCGCKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE07</accession>
    <name>A0A386PE07_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05885</name>
        <name evidence="6" type="ORF">EI377_00375</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01880"/>
    <dbReference type="EnsemblBacteria" id="AYE34030">
        <property type="protein sequence ID" value="AYE34030"/>
        <property type="gene ID" value="CP523_05885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59403">
        <property type="protein sequence ID" value="QAS59403"/>
        <property type="gene ID" value="EI377_00375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="25065" checksum="F765C1BB0485D7B6" modified="2018-12-05" version="1">MELIKLKGLSKKYGENFYALKDVNLDIMEKDFVSIMGPSGSGKSTLLNIIGCMDSVTSGEYYLDGKLVNKLNGNKLSLIRNKDISFVFQHFAIMKDYNVYDNVELPLLRRKLSKKERKSKIKEILKRLDIEDQIKKMPNELSGGQQQRVAIARALVSEAKIILADEPTGALDKKTGEDIMNLLKELNDEGKTIVLITHDEKVDSYAKRHIKIEDGKLYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE12</accession>
    <name>A0A386PE12_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07210</name>
        <name evidence="3" type="ORF">EI377_01965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673733.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01059"/>
    <dbReference type="EnsemblBacteria" id="AYE34253">
        <property type="protein sequence ID" value="AYE34253"/>
        <property type="gene ID" value="CP523_07210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59659">
        <property type="protein sequence ID" value="QAS59659"/>
        <property type="gene ID" value="EI377_01965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="214"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="35147" checksum="68C4111C19C85162" modified="2018-12-05" version="1">MNFIAIDFETANEKRNSPCSIGIVVVKDSKVVERIHYLIRPKEMRFMPINIGIHGIRPSMVENELEFNHIWDKIKDYFNDSLVIAHNASFDISVLRNTLELYGLKLPCFEYICTMKLSRNFYYKLDNSKLNTVNKFLGYEFNHHDALADALACSNILLNISKELDTKDVGEISKLLGVTIGRVFTNGYTPSSTKGRVYKVSNKESLSKNEIEEFNIDAFKDEVIVFTGGLSSMTRDEATVLVRKLGGSVGSSVTKKTTCIVTNTKDINDLKREEMSNKLRRAVDLKDKGQKIKFLSEDEFLKKSILIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE34</accession>
    <name>A0A386PE34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp20 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07375</name>
        <name evidence="5" type="ORF">EI377_02065</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673770.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01084"/>
    <dbReference type="EnsemblBacteria" id="AYE34283">
        <property type="protein sequence ID" value="AYE34283"/>
        <property type="gene ID" value="CP523_07375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59677">
        <property type="protein sequence ID" value="QAS59677"/>
        <property type="gene ID" value="EI377_02065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="104"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="25363" checksum="67B9EC0F96F26384" modified="2018-12-05" version="1">MFQMLPFIFKGMFNGMMNNNYNNGWNMNNNNWNMNNNYNNWNQNNNYNNGWNGNNNLNLEDTFANTFNTVFTQVFSTLINNTDLIDDIVDSVINSDVVASMMDEIDGLGEIDFKITNYNDKYLIDGVLPGIDKKSIDIDYENERVLIKVKKSQVFSNGVNTMVAFVQPGENIEKSFYVPGVDKAQIRATYRDNNLKIYLPKKTKEEEATIIDVDDFTESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEB3</accession>
    <name>A0A386PEB3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="10" type="ORF">CP523_08015</name>
        <name evidence="11" type="ORF">EI377_02775</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675933.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00718"/>
    <dbReference type="EnsemblBacteria" id="AYE34373">
        <property type="protein sequence ID" value="AYE34373"/>
        <property type="gene ID" value="CP523_08015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59779">
        <property type="protein sequence ID" value="QAS59779"/>
        <property type="gene ID" value="EI377_02775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08015"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="10"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="316"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="414" mass="45215" checksum="EE64A4A4A4C15614" modified="2018-12-05" version="1">MSELITKGQLAKEASYELGNASTSRKNEALENMAKKLLNNKDEIIKANELDLKVAMEKGTSKAMLDRLALNSQRIDDMADGLRQIVALPDPVGEVLSMWKRPNGLQIGQQRVAMGVIGIIYEARPNVTCDAAGLCLKTGNAVILRGGSEAINSNKAIVKVLSEAVEEVGLPKNSVQLVENTSREVATQMMKLNDYIDVLIPRGGAGLIQTVVNNATVPVIETGVGNCHIYVDEECDLDMAKNIIVNAKTSRPAVCNAAEKMLINEKISDKFLPIIANALKEKDVEIRGDEKVRNLVKEAVEATEEDWSKEYLDYIIGAKVVKDIDEAINHINKYGSGHSEAIVTKSYENSQKFMQRVSAAAVYVNASTRFTDGCEFGFGAEIGISTQKLHARGPMGLKELTTIKYIIYGNGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED4</accession>
    <name>A0A386PED4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Spore cortex-lytic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08130</name>
        <name evidence="3" type="ORF">EI377_02885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00740"/>
    <dbReference type="EnsemblBacteria" id="AYE34395">
        <property type="protein sequence ID" value="AYE34395"/>
        <property type="gene ID" value="CP523_08130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59800">
        <property type="protein sequence ID" value="QAS59800"/>
        <property type="gene ID" value="EI377_02885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="338"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="444" mass="50208" checksum="F8C3458F788D1D6D" modified="2018-12-05" version="1">MAEKGRLKIQCFKSNTYIPVDNTKIIITPSEGTGMETNEIELTTNSMGETEVVELEAPPFAYSQEPTGQIPYSTYDIRVEREGFQPLLINRCQVFPEEIALQPCNLLEVGTRSLRADVINIQPNVLNGDFPAKIPEEVDKPLPPPSSGVVLQKPVVPEFITVHAGGPNNDAAPNYRVLYKDYIKNVASCEIYSTWSDNTIRSNVYAIISFTLNRIYTEWYRGKGKNFDITNSTAYDHAFNYGRNFFESISVVVDDIFATYVRRFGRKQPLLTQYCDGKNVSCPEWMTQWGSKYLGDQGKTPYEILTYFYGNDIELVTAEQVKGSPKSYPGYDLTIGSTGEEVKTVQEYLNRIAQNYPLIPKSAVDGVYGIKTQEAVNVFQGVFNLPKTGIVDYATWYKISDVYVGVTRIAELRGSIPAKENIFIPPRSFDNYYDVSVPRFTYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEJ7</accession>
    <name>A0A386PEJ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA</name>
        <name evidence="7" type="ORF">CP523_01885</name>
        <name evidence="8" type="ORF">EI377_12390</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678295.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01171"/>
    <dbReference type="EnsemblBacteria" id="AYE33298">
        <property type="protein sequence ID" value="AYE33298"/>
        <property type="gene ID" value="CP523_01885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61467">
        <property type="protein sequence ID" value="QAS61467"/>
        <property type="gene ID" value="EI377_12390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="11589" checksum="78B18C7449981AA0" modified="2018-12-05" version="1">MVQHLSEMNFNQEVLQNKGVVLVDFWATWCGPCKMIAPIVEDLAKEVANAKFTKVDVDANPTLANRYQISSIPTLMIFKNGAPVETLVGFMPKESLKVAVTRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM3</accession>
    <name>A0A386PEM3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05105</name>
        <name evidence="2" type="ORF">EI377_15665</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676201.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01811"/>
    <dbReference type="EnsemblBacteria" id="AYE33897">
        <property type="protein sequence ID" value="AYE33897"/>
        <property type="gene ID" value="CP523_05105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62048">
        <property type="protein sequence ID" value="QAS62048"/>
        <property type="gene ID" value="EI377_15665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="179" mass="21392" checksum="6DB85C89621C3227" modified="2018-12-05" version="1">MRELLRKAKLGDKRAKELIIIACKPLIIKSYMSINIKNFEKEDIEQICVMVVLNVIEKIDLEKERLFFAYLKRSINNKLIDLKKRCDKNIIYIDNKELSENRMLKVETLEEEVLKREVINRLKNIVLSFSKDERILFEMVYINGEKLTSYADFMGINYSDAYKMKVKIRKSISSYYMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEN9</accession>
    <name>A0A386PEN9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_08775</name>
        <name evidence="8" type="ORF">EI377_03525</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876904.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02696"/>
    <dbReference type="EnsemblBacteria" id="AYE34503">
        <property type="protein sequence ID" value="AYE34503"/>
        <property type="gene ID" value="CP523_08775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59905">
        <property type="protein sequence ID" value="QAS59905"/>
        <property type="gene ID" value="EI377_03525"/>
    </dbReference>
    <dbReference type="GeneID" id="66300417"/>
    <dbReference type="KEGG" id="csep:CP523_08775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="56" mass="5682" checksum="6AB8254399DDFEC9" modified="2018-12-05" version="1">MAFVIQDSCVNCGACAAECPVNAISQGDTQFVIDADTCIDCGNCANVCPVGAPVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ0</accession>
    <name>A0A386PEQ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxyguanosinetriphosphate triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02160</name>
        <name evidence="3" type="ORF">EI377_12680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674057.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00535"/>
    <dbReference type="EnsemblBacteria" id="AYE33348">
        <property type="protein sequence ID" value="AYE33348"/>
        <property type="gene ID" value="CP523_02160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61518">
        <property type="protein sequence ID" value="QAS61518"/>
        <property type="gene ID" value="EI377_12680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="75"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="342" mass="39438" checksum="82EA0F2FE215AA4F" modified="2018-12-05" version="1">MNIREKIEKFERLTLIKEAMLSGQSLGREKIEERDPIRTCFMVDRDRIIHSKSFRRLKHKTQVYIKTFGDHYRNRLTHTLEVSQIARTIGVGIGLNENLIEAIALGHDLGHVAFAHNGEEVLNEFLKEGFRHNEQSVRVVKKLERDGRGLNLTEEVLDGILNHSGLGIVKNKAKTLEGRVVKISDKIAYLNHDIDDSIRAGLLEDKDIPKNIRSILGTTHSERIDTLVLDMIKNTNKNLNEGIVDVALSKEVWEAMNELRRYMFKNIYLGDILKQEREKAKFILSQLIEHYCKYPEKLPDTYKKILVEDGLDRAVADYIAGMSDDYCLICFNSIFVPKFVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER9</accession>
    <name>A0A386PER9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsS</name>
        <name evidence="8" type="ORF">CP523_08995</name>
        <name evidence="9" type="ORF">EI377_03740</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876943.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00239"/>
    <dbReference type="EnsemblBacteria" id="AYE34545">
        <property type="protein sequence ID" value="AYE34545"/>
        <property type="gene ID" value="CP523_08995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59945">
        <property type="protein sequence ID" value="QAS59945"/>
        <property type="gene ID" value="EI377_03740"/>
    </dbReference>
    <dbReference type="GeneID" id="66300458"/>
    <dbReference type="KEGG" id="csep:CP523_08995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="94" mass="10757" checksum="EA1E89ED539B1F87" modified="2018-12-05" version="1">MSRSTKKGPFVHEGLLKKIEEMNASGEKKVVKTWSRSSTIFPQMIGHTIAVHDGRKHVPVFITEDMVGQKLGEFALTRTYRGHDYDEKASRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PES0</accession>
    <name>A0A386PES0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin--nitrite reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Nitrite/sulfite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02260</name>
        <name evidence="4" type="ORF">EI377_12780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674018.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00515"/>
    <dbReference type="EnsemblBacteria" id="AYE33368">
        <property type="protein sequence ID" value="AYE33368"/>
        <property type="gene ID" value="CP523_02260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61538">
        <property type="protein sequence ID" value="QAS61538"/>
        <property type="gene ID" value="EI377_12780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="118"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="303"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="379"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="517" mass="58582" checksum="EFDB82FC52D380C5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY5</accession>
    <name>A0A386PEY5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07950</name>
        <name evidence="3" type="ORF">EI377_02710</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675905.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00705"/>
    <dbReference type="EnsemblBacteria" id="AYE34360">
        <property type="protein sequence ID" value="AYE34360"/>
        <property type="gene ID" value="CP523_07950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59766">
        <property type="protein sequence ID" value="QAS59766"/>
        <property type="gene ID" value="EI377_02710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="30682" checksum="7509D46E5692EBC1" modified="2018-12-05" version="1">MGDIIYRLLLFLNSRKNEDLDYTIATTMLHNIKDIPNMSINKLADICYTSPAAITRFCRKLGYSNLSEFKQSTQFNINSYDLGLMRPKAINFSLAREDLLKNMYTEVDKEINSLIENIDFKIVDMVINLIFSSPNVSIFGTQYSQLMAQDLQRRLVNVGKIINHANDVQEQEKLAEDLTEGSLAILISPTGRFSIYHERLWKKIKESSAIVVIITGAKNDEYLKRGNYILSLPSSENSNLYIQPYRYSLCYLIEYLYIRYGSLYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEZ4</accession>
    <name>A0A386PEZ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_08000</name>
        <name evidence="5" type="ORF">EI377_02760</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675924.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00715"/>
    <dbReference type="EnsemblBacteria" id="AYE34370">
        <property type="protein sequence ID" value="AYE34370"/>
        <property type="gene ID" value="CP523_08000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59776">
        <property type="protein sequence ID" value="QAS59776"/>
        <property type="gene ID" value="EI377_02760"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="158" mass="16769" checksum="041FBA8DA336BF9B" modified="2018-12-05" version="1">MFKFFSKPLNLLAPASGKTIKLSDVPDPVFSQKMVGDGIAIDITGDTIVAPADGEITLIMDSKHAFGMSLENNVEVLVHVGLDTVTLKGEGFEQLVNQGTKVTAGTPILKINRDLIQSKGISLITPVLITNADLVKKLEGLAGLNVTAGKDPIINYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF18</accession>
    <name>A0A386PF18_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mac-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675015.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01877"/>
    <dbReference type="EnsemblBacteria" id="AYE34027">
        <property type="protein sequence ID" value="AYE34027"/>
        <property type="gene ID" value="CP523_05870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015117">
        <property type="entry name" value="IdeS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09028">
        <property type="entry name" value="Mac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017339325" description="Mac-1 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Mac-1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="429" mass="49383" checksum="2C47579E52B5122A" modified="2018-12-05" version="1">MLKKTKIISAILLSGILSLNFSKTLTTYADLTTLNYDSKYDLNNDSIINELDIDKISKHYNNQKDSADWTEEFDFNNDGIIDIFDIIKISKRNGIKRTIKRTIKKTIKKSSENALEFQNLLAANKNVTTTKDAAGKKIYNVWVKGITPPTEDDFTNIDLGNNYALKVAPWKSGQGWYDINKFKDGSDDLLCSGAVATNMLHWWFDQNKEYIDRYLKQNPNNGKSYNGTLDIHKIPEFHNQQNSDIFNTIKNRLGRGPIWADRAVLWYTNGFDVNFPAPIESPYISSHIDRRGGVFRDVFKEYGLTERFFARTYDAFNRGLIRCLKEDRALGISHKSPFLDSHIITLWGASFDEDGNIIGIYTCDSDDEKHKISKDVLYGMRYNKIVKDSSGIARMTNYNGNNNDIGARVLDLYYLSLEKDQWKKYFNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF26</accession>
    <name>A0A386PF26_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05920</name>
        <name evidence="3" type="ORF">EI377_00410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675040.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34037">
        <property type="protein sequence ID" value="AYE34037"/>
        <property type="gene ID" value="CP523_05920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59410">
        <property type="protein sequence ID" value="QAS59410"/>
        <property type="gene ID" value="EI377_00410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="31560" checksum="1630322EDF801E44" modified="2018-12-05" version="1">MNKKFLSLCLFNFKTMKLNITLFFLFLLSTTSIYVALTYDSTQIKEFNMWNFYSVMFTGGPLVSALLFFYNLFLLFHCFQSEKDSLFLKIRSGNSLLWFFSKIISIFLLNIIAITIATIIILLIGWLFWGFGNIWGGVNIHNSTSYKAFYSPIKIVIFNIVTYSFFITFLSEIVGYLMTKLKNKFIVIFLFILYFMADKTVNLKYFSFDKYTDLNCRCYYLYLNSNNYFTIKEGIFIPILLTVIFSLIFILLYFIKRFYLKRNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF83</accession>
    <name>A0A386PF83_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_06235</name>
        <name evidence="6" type="ORF">EI377_00710</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00017"/>
    <dbReference type="EnsemblBacteria" id="AYE34097">
        <property type="protein sequence ID" value="AYE34097"/>
        <property type="gene ID" value="CP523_06235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59464">
        <property type="protein sequence ID" value="QAS59464"/>
        <property type="gene ID" value="EI377_00710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="24850" checksum="BB27C7C3EC37C6EF" modified="2018-12-05" version="1">MIKIKAVYKNFGNEIISFNDIVFEDNKSYIILGPSGCGKSTLLNLLSGNIKADNGSIQVNTKNYSYKLEDLSYEKLQEYRRNNISYVSQEFNLFDNFTVYDNLNIINEIKPTKIAIEKAIKLVGLTNKLKQKVRTLSGGEKQRVCIARALLQGGDIILCDEPTASLNQGLANDIIKLIIELQKKTKSSLLVVTHDERLIENFDEVIYYEDFIKVDLGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA4</accession>
    <name>A0A386PFA4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_06350</name>
        <name evidence="10" type="ORF">EI377_00820</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677778.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02429"/>
    <dbReference type="EnsemblBacteria" id="AYE34117">
        <property type="protein sequence ID" value="AYE34117"/>
        <property type="gene ID" value="CP523_06350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59483">
        <property type="protein sequence ID" value="QAS59483"/>
        <property type="gene ID" value="EI377_00820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="311"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="402" mass="43478" checksum="3172ACCDA5302A64" modified="2018-12-05" version="1">MKFRVLIFSALRNLNRNKKRSFLTMLGIIIGIAAVIAIVALGEGYKTKTIKEFTGEDEGKVVLEASLTNEDPSNAMKISGNIFTNSDKTSVAQLEGIEKVDFNYDDNKFGEFISVDVRNKEFQGLAKKVKDGDFKDILGRNLTKSDSESKKRVIVISESLITDKVGKIEDLLGGVATVKGLTFEIVGIMKKAPDEEFSFFNSSGDIQIPEGTYDKYFGKSKTIVGLKITLNKDADVKKSIKSIENTLNQVGTNRSKGKYTVMDTSGIIKLMGGVLNTITLFIAAVAGISLFIAGIGVMNMIYTSVSERTIEIGIKRALGAKKKDIRREFLIEGVVITLTGGLIGYILGIIIANIISAFMKLVITPSLYTASIAIAISILVGTASSILPAKKAASSNTVDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFI2</accession>
    <name>A0A386PFI2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">minC</name>
        <name evidence="6" type="ORF">CP523_10600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01381"/>
    <dbReference type="EnsemblBacteria" id="AYE34815">
        <property type="protein sequence ID" value="AYE34815"/>
        <property type="gene ID" value="CP523_10600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01222">
        <property type="entry name" value="minC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <feature type="domain" description="MinC_C" evidence="5">
        <location>
            <begin position="106"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="214" mass="23873" checksum="FC0723C7DF3997A1" modified="2018-12-05" version="1">MMDDRIQIRGNKEGINAIIEMEKFNNFNDMLDLLINKLTAGKSFYKGSSLKITANLEKVNEIDIKRLKDTLFEEILIKECTFEEYKKDEEKDDKIFSGVYEGKTKFIKKTVRGGQLINYPGNIVIIGDVNNGAEVHAGGNIVVLGTIKGKVHAGASGNSKAIISAFNLQPELLQIGDVITISPEDSSKPLYPEIAKIKDDTIVVEPYLPNKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN5</accession>
    <name>A0A386PFN5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsH</name>
        <name evidence="11" type="ORF">CP523_06060</name>
        <name evidence="12" type="ORF">EI377_00540</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675101.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01913"/>
    <dbReference type="EnsemblBacteria" id="AYE34064">
        <property type="protein sequence ID" value="AYE34064"/>
        <property type="gene ID" value="CP523_06060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59435">
        <property type="protein sequence ID" value="QAS59435"/>
        <property type="gene ID" value="EI377_00540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="202"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="210"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="639" mass="71551" checksum="78D3D6F5BCDBA32A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN9</accession>
    <name>A0A386PFN9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04760</name>
        <name evidence="3" type="ORF">EI377_15270</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33831">
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        <property type="gene ID" value="CP523_04760"/>
    </dbReference>
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        <property type="gene ID" value="EI377_15270"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="75" mass="8731" checksum="C039972563508AB3" modified="2018-12-05" version="1">MKIFKKGYLFNTFTSIIILVSFLITIKIDNDSRLPQNANTDYFMNSLPYIYLILICLIALITFNLYKAITTKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFP2</accession>
    <name>A0A386PFP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00245</name>
        <name evidence="6" type="ORF">EI377_10640</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677372.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01183"/>
    <dbReference type="EnsemblBacteria" id="AYE32989">
        <property type="protein sequence ID" value="AYE32989"/>
        <property type="gene ID" value="CP523_00245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61143">
        <property type="protein sequence ID" value="QAS61143"/>
        <property type="gene ID" value="EI377_10640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="251" mass="28037" checksum="896A9926103E6336" modified="2018-12-05" version="1">MTSRYTKLLEIVNENKRIEVSKLAELLNVSQVTVRKDLDVLCERGLLKREHGYAVTTSTSDDINSRLAFNYNIKRKIANLASELVVDGETVMVESGSSCALLAEELAYNKKDITIITNSVFIASHIREGNAKVVLLGGDYQPESQVVVGPLTKKCVEDFFVDKLFVGTDGYNSKIGFTGKNLMRTETVKVMSENANKLIILTESSKFSERGVVSQFKTEEVDYVITDDNIPKDVLENLKNKNIEVKMVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ5</accession>
    <name>A0A386PFQ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentapeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06165</name>
        <name evidence="3" type="ORF">EI377_00645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01934"/>
    <dbReference type="EnsemblBacteria" id="AYE34084">
        <property type="protein sequence ID" value="AYE34084"/>
        <property type="gene ID" value="CP523_06165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59454">
        <property type="protein sequence ID" value="QAS59454"/>
        <property type="gene ID" value="EI377_00645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="395" mass="45708" checksum="906DC304B9CCFA56" modified="2018-12-05" version="1">MAYINFKEERVATKKQLHKRLKNNSKLFKKMRESKTISNTYTPDKEYSYKDFDDKIFGEHHIKGEENFKEISNKDIVCSTFKNCIFENIKFKDCRFIGCYFIKCEFSSGGVAFENCSFFKEESDSIPSLNKNDNFSCDFKDCNIYGKFLNCIMSFSIFENCKITNSNFNLSDMTSSIIINSEFKMTIMADVDLTGAKIMNTYIEDLEFRDKYKSKMDEKTFIDSIKPRKKDRSEYEGLYMVYETLANKFKENQLKNNFGEYYFLAQRMQFKTLKPIPKIISFLSWVTCGYGERPLYAVYSSLVIILIFAVIYLILGIDIDGQLVNFYTITNNFNLSELVEYLNEAINLSVGMFAGVGFNNAQPTPSNFMTTNIEMLVGVAMMGIGIGAITKKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU7</accession>
    <name>A0A386PFU7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="5 12">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">mprF</name>
        <name evidence="14" type="ORF">CP523_04355</name>
        <name evidence="15" type="ORF">EI377_14890</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the LPG synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="5 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00407"/>
    <dbReference type="EnsemblBacteria" id="AYE33758">
        <property type="protein sequence ID" value="AYE33758"/>
        <property type="gene ID" value="CP523_04355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61915">
        <property type="protein sequence ID" value="QAS61915"/>
        <property type="gene ID" value="EI377_14890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="13">
        <location>
            <begin position="526"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="843" mass="97039" checksum="0A7D4EB2C8BF7CCE" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX2</accession>
    <name>A0A386PFX2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">uvrA</name>
        <name evidence="16" type="ORF">CP523_06435</name>
        <name evidence="17" type="ORF">EI377_00910</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677425.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02163"/>
    <dbReference type="EnsemblBacteria" id="AYE34134">
        <property type="protein sequence ID" value="AYE34134"/>
        <property type="gene ID" value="CP523_06435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59501">
        <property type="protein sequence ID" value="QAS59501"/>
        <property type="gene ID" value="EI377_00910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="600"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="740"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="641"/>
            <end position="648"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE34134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS59501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="941" mass="104665" checksum="631CE6CC8BA0BF09" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX9</accession>
    <name>A0A386PFX9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11325</name>
        <name evidence="9" type="ORF">EI377_06145</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673247.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02822"/>
    <dbReference type="EnsemblBacteria" id="AYE34955">
        <property type="protein sequence ID" value="AYE34955"/>
        <property type="gene ID" value="CP523_11325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60350">
        <property type="protein sequence ID" value="QAS60350"/>
        <property type="gene ID" value="EI377_06145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="335" mass="34913" checksum="1C8D37271F1427FE" modified="2018-12-05" version="1">MKKKSKSIIKVTSVILLLSCILCVLALISMSIGSARYSLSELINNLLSEENNPVKIIIYNLRLPRIISAILIGAALSVSGALLQAVMRNPLADPGTIGVSAGAGAAATTILLIFPHMTTAVPVFAFGGAALACGLIYLLAWRGGIDPVRIILSGVAINSVLGGYNGFLQMMYSDNLQGVLGFLNGSLAGSSWNNVRTLLIYVTIGLLLAIVCIKSANALQLGDEMAKNLGINVNVSRIVLSAISAFLAASTVSAVGMIGFVGLVVPHIARIIVGSDYKIMVPTSMLLGAVILLLADTVGRSIVPGMDIPVGTIMSMIGGPFFLYMLRKKGKVSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ2</accession>
    <name>A0A386PFZ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar motor switch phosphatase FliY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fliY</name>
        <name evidence="9" type="ORF">CP523_02720</name>
        <name evidence="10" type="ORF">EI377_13245</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676956.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00950"/>
    <dbReference type="EnsemblBacteria" id="AYE33452">
        <property type="protein sequence ID" value="AYE33452"/>
        <property type="gene ID" value="CP523_02720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61623">
        <property type="protein sequence ID" value="QAS61623"/>
        <property type="gene ID" value="EI377_13245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="8">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="8">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FliMN_C" evidence="7">
        <location>
            <begin position="297"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="377" mass="41270" checksum="0BD469E73796DF31" modified="2018-12-05" version="1">MSNGFLSQEEIDSLLNGDSGSEKENNVEEEQLSDIEKDLLGEIGNISMGSASTALHQIINQQVHITTPKVSITTLKEIKEGFDYPTIILDVEYVTGIIGRNILIMKITDAAVIANLMMGGNGEVDSIELSDIEVSAVQEAMNQMIGSAATSMATMFAREVNISPPHSKIWRALEESISDSIDEKEEIVRVCFDLKIGELLESNIMQILPIPTAKKIVSIMMGEEIEKFNNVEAKIEDIKAEEIAESNLQQDISSSRVEEAIMSKEINVNQPTIEVNKASFVPLESKKIGEANKNIDLILDVPLNISVVLGRTKKSIKDILSLSTGSLIELDKLAEEPVEVLINGKQIAHGEVVVIDESFGVRITSIVNGVDRINSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG17</accession>
    <name>A0A386PG17_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxyacetone kinase transcriptional activator DhaS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dhaS</name>
        <name evidence="3" type="ORF">CP523_11475</name>
        <name evidence="4" type="ORF">EI377_06290</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673302.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02852"/>
    <dbReference type="EnsemblBacteria" id="AYE34983">
        <property type="protein sequence ID" value="AYE34983"/>
        <property type="gene ID" value="CP523_11475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60376">
        <property type="protein sequence ID" value="QAS60376"/>
        <property type="gene ID" value="EI377_06290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012738">
        <property type="entry name" value="Tscrpt_reg_DhaS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02366">
        <property type="entry name" value="DHAK_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="186" mass="21666" checksum="04F0FC2DEB7E6096" modified="2018-12-05" version="1">MTLMTKKALANSLKNTMNKKSINKITIKEIVSNCGVNRQTFYYHFQDIYHLLGWIYKTEAVDSISNYKSYDSWQQGFLKIFQYVEKNKDFCINTFNSIGREHLENFLHNEVFNLLINVVEEVSKDYNISSNEKNFIADFYTFAFIGILTSWMKSGMKDSPENIISKVEKLVAGDIKKALNKTTQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG58</accession>
    <name>A0A386PG58_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10350</name>
        <name evidence="6" type="ORF">EI377_05140</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01425"/>
    <dbReference type="EnsemblBacteria" id="AYE34770">
        <property type="protein sequence ID" value="AYE34770"/>
        <property type="gene ID" value="CP523_10350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60170">
        <property type="protein sequence ID" value="QAS60170"/>
        <property type="gene ID" value="EI377_05140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="25688" checksum="B0B462EB36E44D77" modified="2018-12-05" version="1">MLEINNLNYSYDGEVKVLDDVTFKIEKGKIYCLLGVNGAGKTTLFNCITGFLNSNLDLDENLINDKILYIQDEMNFYKNLSGIEFIKLIFDLKEKLLDEEKLKILLKDLKMEEKITDTISTYSLGTKQKLVLIIGFLLKYEYIFMDEPFGAIDFISAEYIINLLQKYRDQNNGIIISTHLIDIAHEIADEILFINNGKVYQKRNDFIDTKQLKEWIRRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC9</accession>
    <name>A0A386PGC9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrkA family serine protein kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Serine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04125</name>
        <name evidence="3" type="ORF">EI377_14645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676879.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02759"/>
    <dbReference type="EnsemblBacteria" id="AYE33716">
        <property type="protein sequence ID" value="AYE33716"/>
        <property type="gene ID" value="CP523_04125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61871">
        <property type="protein sequence ID" value="QAS61871"/>
        <property type="gene ID" value="EI377_14645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016230">
        <property type="entry name" value="Ser_kinase_PrkA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000549">
        <property type="entry name" value="Ser_prot_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="21"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="640" mass="73429" checksum="7A05C2F063F20172" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG2</accession>
    <name>A0A386PGG2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03690</name>
        <name evidence="3" type="ORF">EI377_14220</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02207"/>
    <dbReference type="EnsemblBacteria" id="AYE33632">
        <property type="protein sequence ID" value="AYE33632"/>
        <property type="gene ID" value="CP523_03690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61796">
        <property type="protein sequence ID" value="QAS61796"/>
        <property type="gene ID" value="EI377_14220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="414" mass="48565" checksum="E8FFFBDEC194D887" modified="2018-12-05" version="1">MNNLWYSFRELKNNLLFKIIIIIQITIAIVLLYRVNELRSYETNKLKAMGEITNNKKIYKLVSEYESIDKFLEDKKIPNKFSNFSRSIQERFTLVTTKYGEMTLKNFDGIEKFLDKDLQNAEVEEGYSLVNSLQCTSNFFEVFNIKLSDGSFDEFNKFTKINFLEWDEQCIPIILGDSYRKIFKLNEVIETAHIKCRVVGFMNENQFILDKGIYDLCRVKNLNTFIVCPIPKNLMDANINNAFLIVDNKTSDDFNFIKNYIDNLAEKQNVKLSITDPSENITNFVQSLQYNANIKLIIIYFIVFFVTIGLIVIFTNSISTRRKEFSIHIIHGATIKDICIRIILEHVFLVSLSTIFSFLYLIKNNVLIITEIIRFEPKLFFQSALILIIIVFLVSLIPIYYLKKYRLNYLIKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH1</accession>
    <name>A0A386PGH1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_12390</name>
        <name evidence="12" type="ORF">EI377_07275</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02035"/>
    <dbReference type="EnsemblBacteria" id="AYE35153">
        <property type="protein sequence ID" value="AYE35153"/>
        <property type="gene ID" value="CP523_12390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60556">
        <property type="protein sequence ID" value="QAS60556"/>
        <property type="gene ID" value="EI377_07275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002102">
        <property type="entry name" value="Cohesin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00963">
        <property type="entry name" value="Cohesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363068" description="Beta-N-acetylhexosaminidase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1502"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="966"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1471"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1268"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1428"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1527" mass="170276" checksum="7591A187FDD8D9BC" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI7</accession>
    <name>A0A386PGI7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanolamine utilization microcompartment protein EutM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">eutM</name>
        <name evidence="3" type="ORF">CP523_12490</name>
        <name evidence="4" type="ORF">EI377_07375</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675313.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02015"/>
    <dbReference type="EnsemblBacteria" id="AYE35173">
        <property type="protein sequence ID" value="AYE35173"/>
        <property type="gene ID" value="CP523_12490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60576">
        <property type="protein sequence ID" value="QAS60576"/>
        <property type="gene ID" value="EI377_07375"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="96" mass="9896" checksum="31273A823122ED22" modified="2018-12-05" version="1">MKYDALGMIETKGLVGAIEAADAMVKAANVYLIGKEYIGGGFVTVMVRGDVGAVKAATDAGAAAAQRVGELTSVHVIPRPHSEVEVILPTTKEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ7</accession>
    <name>A0A386PGJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12540</name>
        <name evidence="3" type="ORF">EI377_07430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675283.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35183">
        <property type="protein sequence ID" value="AYE35183"/>
        <property type="gene ID" value="CP523_12540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60586">
        <property type="protein sequence ID" value="QAS60586"/>
        <property type="gene ID" value="EI377_07430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="242" mass="28831" checksum="9830F63A2E502147" modified="2018-12-05" version="1">MNEKGYTVINNLIFEDDNLTLEEKYFLIVLKRFHYKDIGEIYPTYKVLMSLCSTKRRAKVSKLIKSLMSKDYIEVKKIKGCNCYYFKKDYLLEDFQVTSNPNNRTENNPNNETRNNNRSSKNSYCECSKNETLKIQNKKIYINIINHWNSSGILEANIDRKTIDAIDIILKKYDFEEIIQGIDNYGIVYRSQHYYNYVWTLEGFLTKENGLSRFIRNGDIWTSYLFNSEKKKGYINIEDYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ4</accession>
    <name>A0A386PGQ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_08125</name>
        <name evidence="7" type="ORF">EI377_02880</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00739"/>
    <dbReference type="EnsemblBacteria" id="AYE34394">
        <property type="protein sequence ID" value="AYE34394"/>
        <property type="gene ID" value="CP523_08125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59799">
        <property type="protein sequence ID" value="QAS59799"/>
        <property type="gene ID" value="EI377_02880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="102"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="441"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="600" mass="65753" checksum="41938C7408B458FC" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGR4</accession>
    <name>A0A386PGR4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">A_deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_09305</name>
        <name evidence="5" type="ORF">EI377_04050</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34607">
        <property type="protein sequence ID" value="AYE34607"/>
        <property type="gene ID" value="CP523_09305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60007">
        <property type="protein sequence ID" value="QAS60007"/>
        <property type="gene ID" value="EI377_04050"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="191" mass="21716" checksum="F063726032CF2ADE" modified="2018-12-05" version="1">MRTMPASRVFEVIEAGRKFLGKGVVTVDLYASEEAGFCERFVEPISLAREYGYRVTIHAGETGIGKNVLDAIELLGAERIGHGVFIKDCEEAYNMVKEKDIVLEMCPTSNVQTKAVNGFNSHLIYNFHKDGIKVTVNTDNRTVSNTNMTNEFNIVRDEFKINNEDYRKMYYNSVDASFADSRTKKKLKEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH09</accession>
    <name>A0A386PH09_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF86 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04815</name>
        <name evidence="6" type="ORF">EI377_15325</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33842">
        <property type="protein sequence ID" value="AYE33842"/>
        <property type="gene ID" value="CP523_04815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61988">
        <property type="protein sequence ID" value="QAS61988"/>
        <property type="gene ID" value="EI377_15325"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="42" mass="5056" checksum="0E29D5EA378ECB5B" modified="2018-12-05" version="1">MVGFRNIAVHNYQEVSLKVIKMIIEKHIYDFNEFIYAINKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH96</accession>
    <name>A0A386PH96_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10335</name>
        <name evidence="6" type="ORF">EI377_05115</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674266.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01428"/>
    <dbReference type="EnsemblBacteria" id="AYE34767">
        <property type="protein sequence ID" value="AYE34767"/>
        <property type="gene ID" value="CP523_10335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60166">
        <property type="protein sequence ID" value="QAS60166"/>
        <property type="gene ID" value="EI377_05115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="29187" checksum="53BE6A65EFA37D68" modified="2018-12-05" version="1">MLIGKNISFSYDDKEFINNLDIKIEKGKITTIIGPNGSGKSTLLGMLCSVNKIKNGCIYIDGKNIINYKSKLLAQIIATVYQQNNVPEDIVVEDLVAYGRIPHKGYFEKNNENDYKIIEWAIKSTNVEHLKNKPISHLSGGEKQRVFIALALAQKPKVLFLDEPNTYLDIFNQIELLELVKKLNEENNITVVMVLHDINQAVKYSDNLVIMKNGKIMKFGKSEDIINAEIIESVYNVKGIVTEVAENEKYFIPISVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA3</accession>
    <name>A0A386PHA3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05355</name>
        <name evidence="3" type="ORF">EI377_15920</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02597"/>
    <dbReference type="EnsemblBacteria" id="AYE33942">
        <property type="protein sequence ID" value="AYE33942"/>
        <property type="gene ID" value="CP523_05355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62094">
        <property type="protein sequence ID" value="QAS62094"/>
        <property type="gene ID" value="EI377_15920"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006380">
        <property type="entry name" value="SPP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05116">
        <property type="entry name" value="S6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S6PP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="30662" checksum="96DCA17FE1231EF9" modified="2018-12-05" version="1">MENIYFITDLDRTIIHSKHKGYKCVEMMGEKEITYMTDSAYEKLMELLEHKNLKFIPCTMRNINQTLRVNFIKEYNPEIIICTNGAEIYINGSLDLHWDKKMKSIVNHNELLNNIKYLNNMKEKLKGKINIIEVRNIENFYITVKCASSEDATKFYKEIKDSFSSEVKVIKIKAKIFIINKKINKLKALDYIVDKYGIKHLITSGDSEVDKGFTTRGISILPKHSSFKNENSIITNDSNIKATEEILSEVEKIIFNVTENVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHH5</accession>
    <name>A0A386PHH5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">M15 family peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_12910</name>
        <name evidence="4" type="ORF">EI377_07790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678227.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03030"/>
    <dbReference type="EnsemblBacteria" id="AYE35250">
        <property type="protein sequence ID" value="AYE35250"/>
        <property type="gene ID" value="CP523_12910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60645">
        <property type="protein sequence ID" value="QAS60645"/>
        <property type="gene ID" value="EI377_07790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788331" evidence="1">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="198"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="308" mass="35419" checksum="F26F2D25C1CEB6AD" modified="2018-12-05" version="1">MRRFTKILIIICICLLISMKNIVTFAETITEDELYNINAKRDILVLMLAYQDEVKTVEKDSNGLIYLVMNSGKKIVYDDKKSKTNEEKLINPDLQDMLEVKYSLESIDKVQKGNRDPGRARVYELLNEVYGNTESNITKNLEQVSTAYGTYPFNKKNEAAESLKKALKEASEAAKSNPKIGGCIAPINGTFNYRVVRGTGRLSAHAYGIAIDLNRNNSDYWKWVKEEEGSKRIASYPVELVNAFENNGFVWGGKWEHFDILHFEYRPEFIFKAKYFNNSEIKENENWYNGVPMDEETKAKIDLIDNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM5</accession>
    <name>A0A386PHM5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13175</name>
        <name evidence="3" type="ORF">EI377_08020</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35300">
        <property type="protein sequence ID" value="AYE35300"/>
        <property type="gene ID" value="CP523_13175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60689">
        <property type="protein sequence ID" value="QAS60689"/>
        <property type="gene ID" value="EI377_08020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024978">
        <property type="entry name" value="Homeodomain_phBC6A51-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13022">
        <property type="entry name" value="HTH_Tnp_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_Tnp_1_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="16675" checksum="C2A33BAF4E70383D" modified="2018-12-05" version="1">MAKELLKNKQEIVTREQIQMITMLIEGENITDIAKTIGVTRNTIYAWMGKPTVKAELDRRKRGIINQGNAYILKDLTTFISNIKELANDKSDKRVCLAANQYLIDRILGRTSQVIDTGNSGNSENDGQINEVEAVVERIKLKLKGGNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN9</accession>
    <name>A0A386PHN9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LTA synthase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_09925</name>
        <name evidence="11" type="ORF">EI377_04710</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LTA synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676531.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00314"/>
    <dbReference type="EnsemblBacteria" id="AYE34694">
        <property type="protein sequence ID" value="AYE34694"/>
        <property type="gene ID" value="CP523_09925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60095">
        <property type="protein sequence ID" value="QAS60095"/>
        <property type="gene ID" value="EI377_04710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="9">
        <location>
            <begin position="272"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Ser)" evidence="7">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="621" mass="71792" checksum="E32F7CA49EC5FA46" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ2</accession>
    <name>A0A386PHQ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06260</name>
        <name evidence="3" type="ORF">EI377_00735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02411"/>
    <dbReference type="EnsemblBacteria" id="AYE34102">
        <property type="protein sequence ID" value="AYE34102"/>
        <property type="gene ID" value="CP523_06260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59469">
        <property type="protein sequence ID" value="QAS59469"/>
        <property type="gene ID" value="EI377_00735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="316" mass="36832" checksum="961F6C73C6FE39AB" modified="2018-12-05" version="1">MRFNKIIKPIAFIGIFLIILSVFSAFFVKKTTKEGIGIEEKNTIDYLVIGDSEAYTSVSPIEIWNKHGFTGYNLGVPGQTMQEVYYSLEKALENQIPKVVLLETNAAYTTFGMYVEANRIFENIVKNNFEIYNYHNRWKDISFINQENDDKKLKKPDGNILKGSNYSIKVNAYVKGPYIKETDSVEKIKKVPMYYLNKIVELCNEKNIQLILYTSPTPVNWTYEKHNSIEAFSKENKLPLIDLNLKNDKLGIDWSKDTYDTGDHLNFFGAKKVTNYIGDYLSKNTNLIDHRKDEKYSSWHETWDEYLKLQIRISNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT3</accession>
    <name>A0A386PHT3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SpoIIIAH-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein AH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15045</name>
        <name evidence="4" type="ORF">EI377_10000</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676025.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01275"/>
    <dbReference type="EnsemblBacteria" id="AYE35643">
        <property type="protein sequence ID" value="AYE35643"/>
        <property type="gene ID" value="CP523_15045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61030">
        <property type="protein sequence ID" value="QAS61030"/>
        <property type="gene ID" value="EI377_10000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024232">
        <property type="entry name" value="SpoIIIAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038503">
        <property type="entry name" value="SpoIIIAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12685">
        <property type="entry name" value="SpoIIIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362725" evidence="2">
        <location>
            <begin position="24"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="187" mass="20718" checksum="5FA844279EE9C89F" modified="2018-12-05" version="1">MTKKQFGIIFTLMALIVCVGVLSAKLNKNGLTDPTDFSQVLSGDTVADKKDDGNKKDESKKEEKNDKKDEQTLSTQDSFYNIRSEKEQQAAATKQQLNAIIADANTSQQQKDVATNELTEKTMLEDKEGRIELSIKNKGFEDALCFIQGNNVRVIVKANEVSDADNAVIQEIVEDISSISDVIIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW6</accession>
    <name>A0A386PHW6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678747.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35705">
        <property type="protein sequence ID" value="AYE35705"/>
        <property type="gene ID" value="CP523_15395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="65" mass="7246" checksum="ABF3D74F5CC91F55" modified="2018-12-05" version="1">MKKLSEAENLSLAAILKMEKNGLIMQKAIDSLISDEDLKRQSEASILATEGRIKGIQKFIEDNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY2</accession>
    <name>A0A386PHY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA threonylcarbamoyladenosine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06975</name>
        <name evidence="3" type="ORF">EI377_01460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673659.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01010"/>
    <dbReference type="EnsemblBacteria" id="AYE34216">
        <property type="protein sequence ID" value="AYE34216"/>
        <property type="gene ID" value="CP523_06975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59581">
        <property type="protein sequence ID" value="QAS59581"/>
        <property type="gene ID" value="EI377_01460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="252" mass="27542" checksum="D464212B3866A597" modified="2018-12-05" version="1">MLQHPLSRTELLIGSEGLEKLKGAKVIVFGVGGVGSFTVEALTRAGVGNIILVDDDTVCLTNLNRQIHATYGTISKVKVEVMKERILSINKKCNVITHQVFVTPENIKDIVPDDVDYVVDAIDTVSAKLALAQYCYEKKIKIISSMGTGNKLDPTQFKVSDIYKTKVCPLAKVMRYELRKRGVKKLKVVYSEEMPIKPKTEDVVTCKTGCVCTGGTKKCAAKRQIPGSISFVPPVAGMIIGGEVIKDILEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ1</accession>
    <name>A0A386PHZ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15550</name>
        <name evidence="3" type="ORF">EI377_10260</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AYE35735">
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        <property type="gene ID" value="CP523_15550"/>
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        <property type="gene ID" value="EI377_10260"/>
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    <dbReference type="KEGG" id="csep:CP523_15550"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362724" evidence="1">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="7617" checksum="06E0CC48775CB4EF" modified="2018-12-05" version="1">MSKRSCKSCCCCNRCCNSCCSRGCGCGNSCGCNFNNCCGCGGGFGGCGGGFGGWGGCGGGWFPLLFILLLFGGCCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ2</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
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        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="AYE34226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01023"/>
    <dbReference type="EnsemblBacteria" id="AYE34226">
        <property type="protein sequence ID" value="AYE34226"/>
        <property type="gene ID" value="CP523_07035"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59631">
        <property type="protein sequence ID" value="QAS59631"/>
        <property type="gene ID" value="EI377_01780"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="182"/>
            <end position="203"/>
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            <end position="137"/>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE34226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="414" mass="46970" checksum="D8A37A0B2C34E4B3" modified="2018-12-05" version="1">MLFTLIKNEFIKLVKKAKTWIVFCLFCIFIGLTIFGAFKSDQNMRYNMSPEKQLEYVNEDLKYIDKEIADFKNMSEEDKIKNAQYILETESRKSEAEERKKEYENIITNGVPNDQWKKELDENIKYAEEAVKRWEEKEIDESNQTWYLQDKQRLEEYKYLKDNNIKPLYGWEFEAYGYMKTLMVFLALAVLVSGIAVFMSDIVSGECTPATLKFLLVQPITRGKVLLSKFITATLTTVTMIVGVELIGFGIVNLISPINTSIYPVTIGRLYKSQISKTTGIRELVSVAGSGEMVTNQELFVKAMLLQVLFIITACAVIFLISSVIKSSMVTMATTVVVSVFLTIGCVSLKPLKAIAHLIFLNYADTISVIVGSTPLMYGNVNMTMNNGIIVMIITSILSYVIGHLVFTRKDILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI08</accession>
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        <submittedName>
            <fullName evidence="3">TetR/AcrR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15490</name>
        <name evidence="4" type="ORF">EI377_10195</name>
    </gene>
    <organism evidence="3 5">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 7534</strain>
        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 6">VAT12</strain>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="protein sequence ID" value="AYE35723"/>
        <property type="gene ID" value="CP523_15490"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
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            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="183" mass="21307" checksum="85361CAF906C49CC" modified="2018-12-05" version="1">MPKVIENIEEKIFDAAIKLFGERGYENVDMKAIAKESNIAVGTLYNYYSNKKDLYIRVLETSWEGTFNKIKKISNSIKNDLNKLGEIIECLYYDIKARKGLGHYFIKGNFESKDKEELNADKIVKKIVLSLYEENNTIKEKDELEVEKLVYILLCTIVLLVNKYSTEDKENVEILMKIVNNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI18</accession>
    <name>A0A386PI18_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1002 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="4" type="ORF">EI377_10430</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00549"/>
    <dbReference type="EnsemblBacteria" id="AYE35765">
        <property type="protein sequence ID" value="AYE35765"/>
        <property type="gene ID" value="CP523_15710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61104">
        <property type="protein sequence ID" value="QAS61104"/>
        <property type="gene ID" value="EI377_10430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15710"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009343">
        <property type="entry name" value="DUF1002"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06207">
        <property type="entry name" value="DUF1002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362745" evidence="2">
        <location>
            <begin position="26"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="390" mass="42803" checksum="6E1B4B9644FFDEE2" modified="2018-12-05" version="1">MKKKIFSLITASAIAVSCFTVNVQAQNKERVTFGIDLNDYQEEQMLKEFGVSKDKVSIDRITNDDIIRQLGLDPNDKSNYQGGCYSSSYVKLTDKGGINVQANNLTEVTGLMLSNALVTSGVTSAEVKASSPFPVTGTSALSGILKGFEQAKGEELSLKNKKVAQKEIETTSKLADEIGADEAAAVINDIKTEVIKKAPKNDTEVNKIVDNLTEDYKVNLTNNQKDNIKSLMTEINNLDIDYSKVKNTLNNLGDQLSNALKNAGKELSESGFFQKLLDGISDFFKSIGEWFKSLGNKEAIDNLDNKNSNNPATTNNSNLNSDNNEENKTTDNKSDEKLNSEKNNSNSEDDNKLKEDVNKEKEQSISNTNTESEVNTTNTESQPSSTSQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI42</accession>
    <name>A0A386PI42_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11645</name>
        <name evidence="4" type="ORF">EI377_06460</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673372.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02887"/>
    <dbReference type="EnsemblBacteria" id="AYE35017">
        <property type="protein sequence ID" value="AYE35017"/>
        <property type="gene ID" value="CP523_11645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60410">
        <property type="protein sequence ID" value="QAS60410"/>
        <property type="gene ID" value="EI377_06460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="71"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="210" mass="23723" checksum="B2E2955E9D3BF9EB" modified="2018-12-05" version="1">MKYYSVYRGKSGTPKIFKTWDECKKEVIGCKGAIYKSFKTEKEAVEFLTIMSNSSGKINTQDLEKNEDDILNKGLTIYVDGSFAVDKGNFSYGLVALKDGNVIYKDNGVGFDEEAIPLRNVSGEVLGAIKAVDYAIENNYPEVKIAFDYQGIESWALGTWKRNNKITSNYHEYMKRKMNEINIKFFKIKGHSGNKYNDVADKLAKEALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI54</accession>
    <name>A0A386PI54_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosose dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">2-keto-myo-inositol dehydratase</fullName>
            <shortName evidence="4">2KMI dehydratase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">iolE</name>
        <name evidence="6" type="ORF">CP523_11700</name>
        <name evidence="7" type="ORF">EI377_06520</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O</text>
            <dbReference type="Rhea" id="RHEA:14065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17811"/>
            <dbReference type="ChEBI" id="CHEBI:28446"/>
            <dbReference type="EC" id="4.2.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IolE/MocC family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.44" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673388.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02899"/>
    <dbReference type="EnsemblBacteria" id="AYE35027">
        <property type="protein sequence ID" value="AYE35027"/>
        <property type="gene ID" value="CP523_11700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60421">
        <property type="protein sequence ID" value="QAS60421"/>
        <property type="gene ID" value="EI377_06520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11700"/>
    <dbReference type="UniPathway" id="UPA00076">
        <property type="reaction ID" value="UER00144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050114">
        <property type="term" value="F:myo-inosose-2 dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01672">
        <property type="entry name" value="IolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023952">
        <property type="entry name" value="IolE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030823">
        <property type="entry name" value="IolE/MocC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04379">
        <property type="entry name" value="myo_inos_iolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="5">
        <location>
            <begin position="37"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="297" mass="33911" checksum="EF8943C516927A63" modified="2018-12-05" version="1">MFNENVKLGIAPIGWTNDDMPDLGKENTFEQCISEMALAGFTGTEIGNKYPRDVKVLKKALDLRKMEIASAWFSAFLTTKPYEETEKAFIEHRDFLNSMGAKVIVISEQGHSIQGEIDTPIFGCKYVFNDEEWKRLAEGLNKLGQLAKEKDMKVVYHHHMGTGVQTTEEIDKLMDLTDENLVYLLFDSGHLVCSGEDELVILKKYINRIKHVHLKDVRKDVVDEVRRNKLSFLQGVRKGAFTVPGDGSIDFDPIFKILSENKYEGYLLVEAEQDPKKANPLEYAIKARKYIKQKTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI67</accession>
    <name>A0A386PI67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04480</name>
        <name evidence="5" type="ORF">EI377_15020</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00382"/>
    <dbReference type="EnsemblBacteria" id="AYE35815">
        <property type="protein sequence ID" value="AYE35815"/>
        <property type="gene ID" value="CP523_04480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62235">
        <property type="protein sequence ID" value="QAS62235"/>
        <property type="gene ID" value="EI377_15020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="186" mass="22213" checksum="2B17D932184B28CD" modified="2018-12-05" version="1">MDHELRLIENIQKKGHRESANMLIKVYYREIYGYVFKQLSCNELSADITQEIFISMIKSIDNYNKEKCSFRTWLYKISSNKIIDYYRSKSYKQRIKSQTIDDLDIKCEGSIEDDFIIEETVNEVLNIVNSFEANIQQIFRMKIFSDMTFKEIGKVLDLSESTVKTKYYRLIKRIKVMLEECKSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI90</accession>
    <name>A0A386PI90_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yidD</name>
        <name evidence="2" type="ORF">CP523_07650</name>
        <name evidence="3" type="ORF">EI377_02340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673858.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01139"/>
    <dbReference type="EnsemblBacteria" id="AYE34326">
        <property type="protein sequence ID" value="AYE34326"/>
        <property type="gene ID" value="CP523_07650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59721">
        <property type="protein sequence ID" value="QAS59721"/>
        <property type="gene ID" value="EI377_02340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="69" mass="7893" checksum="C64FE441E0DC4C75" modified="2018-12-05" version="1">MKELMLKAIILYRKYISPTRQPCCRYIPTCSQYAIDAITKYGAIKGGFLSIKRILRCNPFSKGGYDPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA3</accession>
    <name>A0A386PIA3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-unit flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_10955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02525"/>
    <dbReference type="EnsemblBacteria" id="AYE34884">
        <property type="protein sequence ID" value="AYE34884"/>
        <property type="gene ID" value="CP523_10955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="328"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="480" mass="54110" checksum="41D534B588A21F68" modified="2018-12-05" version="1">MKKQKSLINNFIYNTLFTLLNLLFPLITLPYTSRVIEASGIGKVNFANSIVNYFLIIASLGIPLYGVREIAKVRENKKALSKTYSEIFFINLLSTLISIVAYYLMVFNFDYFAKDYKLFIVSGFLLLLNALNIDWFYQGLEEYKYIALRSVVFKVISLVLLFTMVKTREDYINYALINVIALSGNNIINILNINKFTHFSFSGLEFKKHIRPICILLSIQVAVNIYVNLDTTMTGVLAGEVSVGFYSNAVKLNKIIVSVVTSVGTILLPRLSYHIENNNVEEFNTILNKALKVIIMLSIPAMTGVLFLLREIVLLMFKPEFIPVIYTMKILTPLIIILSIGNLFGTQILMPLGKENKLLFSVIIGAVINFTLNLMLIPKMNENGAAVSTIIAELVVMIIQVYIAKSYVKIKLDFKFISKIILSNAVMTIVLYIISRTVDGLISNLISSVIFGVISYIGTSIILKEETVIEILRKNSKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA6</accession>
    <name>A0A386PIA6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">JAB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_10580</name>
        <name evidence="10" type="ORF">EI377_05365</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01385"/>
    <dbReference type="EnsemblBacteria" id="AYE34811">
        <property type="protein sequence ID" value="AYE34811"/>
        <property type="gene ID" value="CP523_10580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60205">
        <property type="protein sequence ID" value="QAS60205"/>
        <property type="gene ID" value="EI377_05365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="107"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="25653" checksum="4E616F5FB75A30D3" modified="2018-12-05" version="1">MKNDIKISDIPKDERPIEKLLLMGPEFLSNAELLAIILRTGTKGENVISLSTRLLSEFEGLDGLFNSNIKDMTSIKGIKDTKASQLIAMIELSKRFNTLRTCKKDIKITSPKDVASLLMNEMINLKQEVLKLIMLDTKNKIIGNKDVFKGTLNSSIVHPREIYSEAIKRNSANIIVCHNHPSGDPEPSKEDINITMRLKECGKIMGIDLLDHIIIGNNQFISLKEKGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG7</accession>
    <name>A0A386PIG7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 4 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14820</name>
        <name evidence="4" type="ORF">EI377_09780</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676103.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01319"/>
    <dbReference type="EnsemblBacteria" id="AYE35600">
        <property type="protein sequence ID" value="AYE35600"/>
        <property type="gene ID" value="CP523_14820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60987">
        <property type="protein sequence ID" value="QAS60987"/>
        <property type="gene ID" value="EI377_09780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="64"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="198"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="382" mass="43581" checksum="3AB71133AD629F4A" modified="2018-12-05" version="1">MHVMFVPSWYHNIRNKVHGSFFKEQALALQEEGIKISIAYNEIWPLTLLGKVNEKKGLNINVEEGLKTFRYKNYNFIPKNPLMFKVFNKRMEKLYKEIVKREGKVDIIHAQSSLWGGISAAYVAKKYNIPLIITEHSSIKKGIYIKESYKPSIKESYKQADKLIVVGNGLKKEISQFSGRNDIVVIHNLIPFDLFKISKNNINEKFKFFSLAFLEGEKGMDTLIKSFRNGFKGENCILQIGGEGSQKESLINLAKNIGIDSQVEFLGALTREEVSNKMSECNAFVLASRYETFGVVYIEALASGKPIIGTFNGGAEDIINNDNGLLVQVDNIEELENAMKYIKENLSKYDSQEIRKSCENRFSKKVIVKEIIKVYEEILKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK2</accession>
    <name>A0A386PIK2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 12">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">murC</name>
        <name evidence="17" type="ORF">CP523_08480</name>
        <name evidence="18" type="ORF">EI377_03230</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674835.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01637"/>
    <dbReference type="EnsemblBacteria" id="AYE34462">
        <property type="protein sequence ID" value="AYE34462"/>
        <property type="gene ID" value="CP523_08480"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59865">
        <property type="protein sequence ID" value="QAS59865"/>
        <property type="gene ID" value="EI377_03230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08480"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase" evidence="14">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="116"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="317"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AYE34462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QAS59865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="457" mass="50563" checksum="423DC9A6A8935DEB" modified="2018-12-05" version="1">MSFDFNKDTNKKVHFIGIGGVSMSGLAAVLLNNGFKVSGSDSKESNVTNKLKASGAEIYIGHKSENLKNVDLVVYTAAIPSDNPEIIEAKKKKIELMSRAEFLGLIMKGHKFNVAVAGTHGKTTCTSMLTHVTLNANLDPTILVGGDLDIINGNFKIGQSEYFITEACEYKESFLKFYPYIGIILNIDADHLDYYKDINHIKATFEKFANLIPDNGFLIGYAEDDKVNDILGKCNCNTLSYGINKGDITAKNISYNNKGCATFTVYKNSEELFDVTLSTTGKHNILNALSTICVGLIFEIPYSDIIKGLLECKGAHKRFEYKGELNGATIIDDYAHHPVEIKATLNTAQLIPHNKIYTIFQPHTYTRTKTLFSEFTESFFDTDELILMDIYAAREKDTGLVSSNELGDALRSKGVNCKNIHSHEEVADYIRKNISNNDLILTVGAGDVVRVADLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL4</accession>
    <name>A0A386PIL4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tilS</name>
        <name evidence="10" type="ORF">CP523_08620</name>
        <name evidence="11" type="ORF">EI377_03370</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674894.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01665"/>
    <dbReference type="EnsemblBacteria" id="AYE34482">
        <property type="protein sequence ID" value="AYE34482"/>
        <property type="gene ID" value="CP523_08620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59884">
        <property type="protein sequence ID" value="QAS59884"/>
        <property type="gene ID" value="EI377_03370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="TilS_C" evidence="9">
        <location>
            <begin position="385"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="54055" checksum="A0CC7671EB086EA0" modified="2018-12-05" version="1">MINKVKHFIEKNKLLNKKDKVLVALSGGPDSICLLHILYSLKDDMKLEIGAAHINHMLRGDDALEDEIYVKEFCEKLGIPCYIDRIDIDRISKEKGISHELAGREERYKFFEEIKSSKGYNKIAIAHNANDQAETVIMRMMRGAGLEGLCGIRVERDNKFIRPILCLNRKEIESYCKLNNLNARIDKTNLEKIYSRNKVRLDILPYMKKNFNKDIIDTINRMATLLQKDNEFIENKANEAYEKNCSEKNGDLVICRELFSLEEALITRVIKKAFIVYSQKYTNFEMKHIYEVIELSKIGTNKKVDLPNEIFAENIYGNIYLKKRLNVDINKNNQIYLSRDALEGLSVEFGEYNVRFNIITNKNNLEFSDNVLIKYFDYDKIKEGLYIRTRKDGDKIKPLGMKGSKKLKDIFINMKVPRENRLTVPIVCFDNEISWVVGYKVSEDFKITKETKNIIKITFSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ7</accession>
    <name>A0A386PIQ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">clpX</name>
        <name evidence="10" type="ORF">CP523_11865</name>
        <name evidence="11" type="ORF">EI377_06685</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673432.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02931"/>
    <dbReference type="EnsemblBacteria" id="AYE35054">
        <property type="protein sequence ID" value="AYE35054"/>
        <property type="gene ID" value="CP523_11865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60447">
        <property type="protein sequence ID" value="QAS60447"/>
        <property type="gene ID" value="EI377_06685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="431" mass="47699" checksum="2E0B451E26A54F2D" modified="2018-12-05" version="1">MAKYEDKKQLKCSFCGKSQEQVKRLIAGPGVYICDECIDLCSEIIADEFEESSELDTTTLPKPNEIKNYLDQYVIGQEKSKKALSVAVYNHYKRISSNLSDDEVELQKSNILLLGPTGSGKTLLAQTLARFLNVPFAIADATTLTEAGYVGEDVENILLKLIQNADYDVEKAEKGIIYIDEIDKIARKSENPSITRDVSGEGVQQALLKILEGTTASVPPQGGRKHPHQEFIQINTSNILFICGGAFDGIDKIIEKRTMTSSIGFGAEIQSKKSKDMGKLLKDIMPGDLLKFGLIPEFVGRLPVVVTLESLDNNALINILTQPKNALVKQYSKLFEIDNVELEFTEDALKAIADEAISRKTGARGLRSIIEEVMVEIMFDIPSDERVSKVIINADCIKSKKSPEVVKLPEGETRPQIKPKKVKQRKGMESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS3</accession>
    <name>A0A386PIS3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor G</fullName>
            <shortName evidence="7">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">fusA</name>
        <name evidence="9" type="ORF">CP523_08950</name>
        <name evidence="10" type="ORF">EI377_03705</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678845.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01789"/>
    <dbReference type="EnsemblBacteria" id="AYE34536">
        <property type="protein sequence ID" value="AYE34536"/>
        <property type="gene ID" value="CP523_08950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59938">
        <property type="protein sequence ID" value="QAS59938"/>
        <property type="gene ID" value="EI377_03705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="686" mass="75581" checksum="79F3DAF6BB376B94" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ9</accession>
    <name>A0A386PIZ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10925</name>
        <name evidence="2" type="ORF">EI377_05720</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677648.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34878">
        <property type="protein sequence ID" value="AYE34878"/>
        <property type="gene ID" value="CP523_10925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60273">
        <property type="protein sequence ID" value="QAS60273"/>
        <property type="gene ID" value="EI377_05720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010866">
        <property type="entry name" value="A-2_8-polyST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07388">
        <property type="entry name" value="A-2_8-polyST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="351" mass="40411" checksum="85EDCB33EEAE9E29" modified="2018-12-05" version="1">MNNLFIVNTPYHITLSLAIINAKGLKNNVLIVLRDFNFVYKDYSYLNESFDEIIEINGLNKLNKASGAKKILEVIKNLFLDIYTTKKAIKNLRALEFDNIFFANDSYVQVQALIHKLKGENTEISYMEDGIACYLSDDKTITSNSLFNKIKIIYNSILITLFNMRKKYENGVCYGSNSYVDKCYVLYPEFIRKELLVKSIQKIEDSNFENALRMSYTKSNIIINDSIIFLVDLFEENLACKYEEVIKYLSSKNKKIYIKYHPRETNFYLDKYLNCSIIKLQSNKNIEALLIGTNKNVVLTGKGSTAFLTLSKISKNQYVVIGEAIGLTIDSRVKKILTDIGVKFPMKIEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJC7</accession>
    <name>A0A386PJC7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34279">
        <property type="protein sequence ID" value="AYE34279"/>
        <property type="gene ID" value="CP523_07355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="393" mass="45362" checksum="D4E016BA1FF43D39" modified="2018-12-05" version="1">MKERLLLGINIRNLRTSLGLSQESLSIKTGVPRAYISDVERGKINITLDKIVTISNALNVSIAQLFINNQEVDIMNSNLTIYYDSLTEASWFRDLNPIFNNATFEIIKPRGNNPKIIEDITMYDKPDIIVLKDNSPILVLEKTSEVPTGHNVGQRFARLVRAIELGIPTIYYYPFDAKKHGEYAGICNLNIRLLEASFKMLDIHDTPLLSIDWLTDTNGELITDGSENNTLKYILKDYIESNFDKYCTSFKNHIQWMRNEYNTRLRNRPSYAKMPPSVKTYTTKEFCSEFNIQEVPQEFLSRKYTYVYNIGMTPASCKRQDPYTGTQFIYDYILCRYGSSVTQKNANLVLYFPKLDSNIWFSKNPNNPNTKSCNWYLTANALLFTDSISFNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJD7</accession>
    <name>A0A386PJD7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Peptide chain release factor 2</fullName>
            <shortName evidence="6">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prfB</name>
        <name evidence="9" type="ORF">CP523_10310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01433"/>
    <dbReference type="EnsemblBacteria" id="AYE34762">
        <property type="protein sequence ID" value="AYE34762"/>
        <property type="gene ID" value="CP523_10310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="8">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="365" mass="41898" checksum="E746B86424910144" modified="2018-12-05" version="1">MLIKLENELSKLINIKNDIKEMGASLDKEALEKKVQELELQMQEKGFWDDLKRAEEVTKESKQIKDKIERYESLKLRVEDVEVLSELMEEDDDESAEEIIEKIKSIEKTLDKYKIEILLSGEYDRNDAILTLHAGVGGTDANDWTDMLLRMYTRWCEKKGFKTEIVDLLQGDEAGIKSVTLKIKGEFAYGYLKAEKGIHRLVRISPFNANGKRQTSFASLEVLPELTNNQDIDIKPEDLKIDTYRASGAGGQHVNKTESAIRITHIPTGIVVQCQNERSQFANKDTAMSMLKSKLIELKERAHKEKIEDLTGELKDMGWGSQIRSYVFHPYNMVKDHRTNEETANLNSVMNGEIDNFIKAYLKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJF2</accession>
    <name>A0A386PJF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13290</name>
        <name evidence="2" type="ORF">EI377_08150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35321">
        <property type="protein sequence ID" value="AYE35321"/>
        <property type="gene ID" value="CP523_13290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60709">
        <property type="protein sequence ID" value="QAS60709"/>
        <property type="gene ID" value="EI377_08150"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="9836" checksum="E84B41073613BBD2" modified="2018-12-05" version="1">MEDYKLVAAKVLTTSEQTLYSSSLGAIVKTILLYNSKEEESKATLTFDSVAFKFKIAAGETKILNSPILTKNIKASGEGINIHITGLEIGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL5</accession>
    <name>A0A386PJL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02985</name>
        <name evidence="6" type="ORF">CP523_04885</name>
        <name evidence="7" type="ORF">CP523_06010</name>
        <name evidence="8" type="ORF">CP523_08285</name>
        <name evidence="9" type="ORF">CP523_10545</name>
        <name evidence="10" type="ORF">CP523_10795</name>
        <name evidence="11" type="ORF">CP523_12315</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33502">
        <property type="protein sequence ID" value="AYE33502"/>
        <property type="gene ID" value="CP523_02985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33855">
        <property type="protein sequence ID" value="AYE33855"/>
        <property type="gene ID" value="CP523_04885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34054">
        <property type="protein sequence ID" value="AYE34054"/>
        <property type="gene ID" value="CP523_06010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34424">
        <property type="protein sequence ID" value="AYE34424"/>
        <property type="gene ID" value="CP523_08285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34805">
        <property type="protein sequence ID" value="AYE34805"/>
        <property type="gene ID" value="CP523_10545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34852">
        <property type="protein sequence ID" value="AYE34852"/>
        <property type="gene ID" value="CP523_10795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35138">
        <property type="protein sequence ID" value="AYE35138"/>
        <property type="gene ID" value="CP523_12315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02985"/>
    <dbReference type="KEGG" id="csep:CP523_04885"/>
    <dbReference type="KEGG" id="csep:CP523_06010"/>
    <dbReference type="KEGG" id="csep:CP523_08285"/>
    <dbReference type="KEGG" id="csep:CP523_10545"/>
    <dbReference type="KEGG" id="csep:CP523_10795"/>
    <dbReference type="KEGG" id="csep:CP523_12315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="340" mass="38745" checksum="14A99165C8673A8A" modified="2018-12-05" version="1">MSKTNIKCPRCNSDKLYKFGMNKQAKQKYQCKQCKRQFVLGDGDGRPKLNNPKCPRCGKGTYLHHAYKHYNRYKCNNKKCNHIIVKHHTTNIDTASSELVSGSLSMKGMRFPLHVILTALTLYFLNNSSTRAISQFLMINSGIKVSHVTIASWTNKFAPFFKQKADKFKASLNLQSDDWHADETVVFINGERYYLWLAIDSETRFILAFHLTKSRSSDSAYALVNEAKKFGEPANFITDRLPSYNEAVATLLPNTTHIPVAPMSSDTNNNLIESFNKTFKAWYKTKKGFNSFQKANNLIYLFIFHYNFIRPHGSLNNCTPAEVAGFASDSFAKNSWFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN7</accession>
    <name>A0A386PJN7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14125</name>
        <name evidence="3" type="ORF">EI377_09030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678475.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03101"/>
    <dbReference type="EnsemblBacteria" id="AYE35474">
        <property type="protein sequence ID" value="AYE35474"/>
        <property type="gene ID" value="CP523_14125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60861">
        <property type="protein sequence ID" value="QAS60861"/>
        <property type="gene ID" value="EI377_09030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="288" mass="31796" checksum="51DB7E5F7669AB3E" modified="2018-12-05" version="1">MRTVIITDSCCDLPIKFVEENNIEVLPIRINLKGQDIPDDLGQTMKPKEFYEMIRTGELPTTSQINSYVFKEAFKKHIDNGDSVIYLGFSSALSGCVNSAKLAKEMLEEEIGDVDISIVDSKSASLGLGLLVYTLWNLINSGLSKDEAVKWIEDNKLKVNHWFTVNDLNHLKRGGRVSAAAATLGTMLNIKPILHVDNEGRLIPVLKVKGRKKSLKTLAEKLNENIVNSEEQVIFISHGDCEDEAIHLKDIILSNKKVKDVIINNIGPAVGSHSGPGTVALFFIGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJP8</accession>
    <name>A0A386PJP8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pyrF</name>
        <name evidence="9" type="ORF">CP523_13950</name>
        <name evidence="10" type="ORF">EI377_08840</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678813.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00157"/>
    <dbReference type="EnsemblBacteria" id="AYE35441">
        <property type="protein sequence ID" value="AYE35441"/>
        <property type="gene ID" value="CP523_13950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60828">
        <property type="protein sequence ID" value="QAS60828"/>
        <property type="gene ID" value="EI377_08840"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13950"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="291" mass="32534" checksum="554E873042229823" modified="2018-12-05" version="1">MRSNIMDKLFNRVNERGVVCVGLDTSIDYIPKYLFEEKDEAQAIFEFNKQIIDSTLDVVSCYKVQIAYYEALGIKGMIAYRDTLKYLREKDAIIIADIKRGDIAATATQYAKAHFQGDFEADFITLSPYMGMDSIEPYIPYLEKGTKGIFSLVRTSNKGAEDIENIDTVDGRKVYAVVGDKLKELGENITGECGYSAIGGVIGCTHVEEGKEIRKRFKNMFFLIPGYGAQGGKAEDVALYLNNGNGGVVNSSRAILLAYKKQEGREKEFAICAREEAIRMRDEIKNAVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR4</accession>
    <name>A0A386PJR4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11045</name>
        <name evidence="2" type="ORF">EI377_05835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677104.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34902">
        <property type="protein sequence ID" value="AYE34902"/>
        <property type="gene ID" value="CP523_11045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60296">
        <property type="protein sequence ID" value="QAS60296"/>
        <property type="gene ID" value="EI377_05835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11045"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="59" mass="6664" checksum="8BEDC99544A4F8CB" modified="2018-12-05" version="1">MNFTKWLLTIIVLTLLTGVLFKFTTTALNIVIILSLISVLVDILIDSNTFHKGKIKNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJW1</accession>
    <name>A0A386PJW1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673241.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02819"/>
    <dbReference type="EnsemblBacteria" id="AYE34952">
        <property type="protein sequence ID" value="AYE34952"/>
        <property type="gene ID" value="CP523_11310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12641">
        <property type="entry name" value="Flavodoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="172" mass="19373" checksum="2DF8E4F32C6C2931" modified="2018-12-05" version="1">MNILITYSSVTGNTKKLAEGIYRNLTKDSELNIEIDKISLTKNIEKYDAILVGYWVDKGAPNKEAEEFMKTIKNKKVGIFATLGAYPDSSYAFNSLLNGEEIIKEDNEVIGKYICQGAVSPKLIEIFKKLDSNSHHSITDEKLKRYKIAALHPNESEIKSAAILFKERLTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK97</accession>
    <name>A0A386PK97_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11930</name>
        <name evidence="3" type="ORF">EI377_06750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02944"/>
    <dbReference type="EnsemblBacteria" id="AYE35066">
        <property type="protein sequence ID" value="AYE35066"/>
        <property type="gene ID" value="CP523_11930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60459">
        <property type="protein sequence ID" value="QAS60459"/>
        <property type="gene ID" value="EI377_06750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="662" mass="73349" checksum="79D92B3AA0A9F1CA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKF8</accession>
    <name>A0A386PKF8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15705</name>
        <name evidence="2" type="ORF">EI377_10425</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678597.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35764">
        <property type="protein sequence ID" value="AYE35764"/>
        <property type="gene ID" value="CP523_15705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61103">
        <property type="protein sequence ID" value="QAS61103"/>
        <property type="gene ID" value="EI377_10425"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="255" mass="30104" checksum="FB5D6C55E645A40E" modified="2018-12-05" version="1">MSKNLNKILDVREVVIEVKYGDTTGNGHNDKISLIEIHENNKQHKFTGEIFIRVENGLTGHIDRIDLESHTGITYKLYLGNFTTNYKEDILVQGFNYILEDKNNNYIFSYIDRKYKEIFNGHKFLEEYIIEAVYKDNYIIEVYCKRLNMMYLITIKYYNKKWLSKIYDKFGILSINAKLINTDLNAVYPIGSTWGEEFGSQEELYIYQTLISHDKEKVIAIIQNRLKWKNGRFVVILQNIAVFGEDRYKIKTTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKG0</accession>
    <name>A0A386PKG0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13885</name>
        <name evidence="2" type="ORF">EI377_08780</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679303.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000078.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00002"/>
    <dbReference type="EnsemblBacteria" id="AYE35428">
        <property type="protein sequence ID" value="AYE35428"/>
        <property type="gene ID" value="CP523_13885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60816">
        <property type="protein sequence ID" value="QAS60816"/>
        <property type="gene ID" value="EI377_08780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="29538" checksum="12F9130F37694803" modified="2018-12-05" version="1">MQQVLSKNADIGFCGPEQVIYINNQGREDYPVLFAQLTQRDGSFLVGRKDEPNFDWEKLKNVKMIGGRPGGMPQMAFEYVLRKNRLDPKTDVNLVTNLDFTATAGAFKAGTGDYVTLFEPTASMLEKEGSGKIVASIGESAGDLPYTCFFSTKSYMDENPEIIEKFTKAIYKGQQWVKTHSDEEVAKSIISFFPGTDKDIIVNVVKNYRKIDALASEPKIEEEDLNRLMDIIESYDKTLLPSRPDFEKIVNNKFAEEAIKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKJ4</accession>
    <name>A0A386PKJ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="8">2.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisC</name>
        <name evidence="7" type="ORF">CP523_13030</name>
        <name evidence="8" type="ORF">EI377_07905</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677824.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02546"/>
    <dbReference type="EnsemblBacteria" id="AYE35272">
        <property type="protein sequence ID" value="AYE35272"/>
        <property type="gene ID" value="CP523_13030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60667">
        <property type="protein sequence ID" value="QAS60667"/>
        <property type="gene ID" value="EI377_07905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="333" mass="38403" checksum="274642E43223D3B9" modified="2018-12-05" version="1">MKMELTKIKLDSNENQLEHYLDIINCIKEIDPKKYPDVTISELRRKIAISCSVKQNEIFCSNGSDILIKVITLGLLKTTDEVIIPEIAFPTYEIAAKIKECKYKKIPLKNYGIDLEATFDAITDDTKLIWISNPHNPTGTILEPEEIEEFLEKIPEHIYVVLDEAYVEFLTEKIPDTIRLYNKFKNLIVLRTFSKAYGLAGARVGYGFAREEIINSFKHVIGPFDLNSYAQALAIKIIDEKEYVKEVRAANKKAMDFYESLFKELNLDYIKSYASFVMVNAGEKADFICEKLLEENIIIKNGKHIEMENWIRISMGNQEQNLKVAKILRDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKS9</accession>
    <name>A0A386PKS9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase dimerization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676134.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01333"/>
    <dbReference type="EnsemblBacteria" id="AYE35588">
        <property type="protein sequence ID" value="AYE35588"/>
        <property type="gene ID" value="CP523_14755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="205"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="439" mass="48634" checksum="F3F34DBD75C30E26" modified="2018-12-05" version="1">MVNYVEQITQLGKEFHNDVITFTQKLIQTPSISCDEKGVADLLLEKMKELGYDEVFRDSMGNVVGIVKGTEAGPTIMYNGHMDHVSPGDINNWEGYDPYGGKLDICEIDNQDKTAKDLVECIHGRAASDVKAGLAAQVYSGGILVRLKKNGFRFKGSYMFTGVVEEEPAETVGMTHLIDKTFAEKGITYDAMISCEATSLKLYCGHRGRTEMLATVLGRTSHGSAPWLGINSIYKSIPLINKLKDELYPSLPSDEKLGQSSISLNIIECSPGALSIVPDKCMLSIDRRTIPGEDAKLALKQVRDIIDEIQKKDSEFKAVVEVKNGIHKSYTGVEYTVPKDMMPWKIAEDHPFVIAAAKGLTDVNQPVKYGYWDFGTDASKTAGIDRKPTIGYSPMQEQYAHTPYDKVRTDFIDKAVIGNVSIFLNVVECHKSAYHPLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKV9</accession>
    <name>A0A386PKV9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dihydroorotate oxidase B, electron transfer subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrK</name>
        <name evidence="9" type="ORF">CP523_13955</name>
        <name evidence="10" type="ORF">EI377_08845</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5 7">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00158"/>
    <dbReference type="EnsemblBacteria" id="AYE35442">
        <property type="protein sequence ID" value="AYE35442"/>
        <property type="gene ID" value="CP523_13955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60829">
        <property type="protein sequence ID" value="QAS60829"/>
        <property type="gene ID" value="EI377_08845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13955"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01211">
        <property type="entry name" value="DHODB_Fe_S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023455">
        <property type="entry name" value="Dihydroorotate_DHASE_ETsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="5 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="245" mass="27230" checksum="DA083FC6CE2323FF" modified="2018-12-05" version="1">MNYTKARVISNKEIVNGIYKMVVEDKNKTKPGQFYMLKIEGKTLLPRPISICEKDSETITFLYAVVGAGTKEFANLKEEDTISLTGPLGNGFNIEEDLGKVALVSGGIGIAPMLELAKRLREKNTNIVMDLYAGFRDDIYLINDLKEFVNNTYISTNTGNYGHRGFITELLKVENYDTVLCCGPEVMMKKVVEMCKENGVKVYVSMEKHMACGVGACLVCTCKTKDGHKRTCKDGPVFDGSYVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL05</accession>
    <name>A0A386PL05_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11605</name>
        <name evidence="3" type="ORF">EI377_06420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02879"/>
    <dbReference type="EnsemblBacteria" id="AYE35009">
        <property type="protein sequence ID" value="AYE35009"/>
        <property type="gene ID" value="CP523_11605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60402">
        <property type="protein sequence ID" value="QAS60402"/>
        <property type="gene ID" value="EI377_06420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="168" mass="19596" checksum="1AA83160C7BF92D0" modified="2018-12-05" version="1">MEDRMESFRLANKDDLFKVSNILKEIINNKPEGLNWTKDYPNEEVIKNDIEKKELFILEINNEILGAVVLNCDEDINYKKIEWNSNKTPLVIHRLFVSRNYMGEGYGSLLLKSVIDKAKNHGFESIRLDTFSKNINAQKLYIKSGFKYKGTINLEGKVGEFFCYEMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL63</accession>
    <name>A0A386PL63_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
            <ecNumber evidence="5">2.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_14085</name>
        <name evidence="5" type="ORF">EI377_08990</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678460.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03093"/>
    <dbReference type="EnsemblBacteria" id="AYE35466">
        <property type="protein sequence ID" value="AYE35466"/>
        <property type="gene ID" value="CP523_14085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60854">
        <property type="protein sequence ID" value="QAS60854"/>
        <property type="gene ID" value="EI377_08990"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="24479" checksum="B1A2A42994C5BB00" modified="2018-12-05" version="1">MFTGIIEEIGEVKFLEKNDKSYKVSIKCKKVLEDVDIGDSISTNGVCLTLIAKEKDFFSAYIMKETLDKSNLTYLDIGSKVNLERAMKVNDRFNGHIVSGHIDSMAEIINFRREDKTTWITLKATKETSKYMVYKGSIAIDGISLTIARLKGETFEISLIPHSQNETTLLRKAIGEKVNIECDILAKYLEKLYFCKDINEESSKISKGFLSENGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLM6</accession>
    <name>A0A386PLM6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678774.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35696">
        <property type="protein sequence ID" value="AYE35696"/>
        <property type="gene ID" value="CP523_15350"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="100" mass="11902" checksum="C93BE51E9BFCAA90" modified="2018-12-05" version="1">MTINEVTKIRESFFRRREVKRKDTADMVYRLSTLITNGTACIMSKDNKPIEFLDMFGDLFSEEKKINEEKRIENQIEINKQHMKDFANRVNLQRKGGEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLU8</accession>
    <name>A0A386PLU8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01935</name>
        <name evidence="4" type="ORF">EI377_12455</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678302.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01161"/>
    <dbReference type="EnsemblBacteria" id="AYE35796">
        <property type="protein sequence ID" value="AYE35796"/>
        <property type="gene ID" value="CP523_01935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62216">
        <property type="protein sequence ID" value="QAS62216"/>
        <property type="gene ID" value="EI377_12455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="111" mass="13124" checksum="36C7A331FD366D24" modified="2018-12-05" version="1">MNILVMIVYFAIMLAAIMLMFTLGRKYVFSKFRVNKWVLLGISVVLFAVQFFLKLTNPWLSILFTLVIVWFFVWFLDIQATGGPKKQEKKIQIRPKAKPNRVKHMQDQKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM34</accession>
    <name>A0A386PM34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15135</name>
        <name evidence="4" type="ORF">EI377_10090</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679007.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00101"/>
    <dbReference type="EnsemblBacteria" id="AYE35659">
        <property type="protein sequence ID" value="AYE35659"/>
        <property type="gene ID" value="CP523_15135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61045">
        <property type="protein sequence ID" value="QAS61045"/>
        <property type="gene ID" value="EI377_10090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="172" mass="19386" checksum="1A69390A6F377862" modified="2018-12-05" version="1">MNLNEKTLKERIIHKGNFMTFVNVDVELPNGKLGNRDILKHPGACAILPFLDDEKVILVKQFRKPLEKTLIEIPAGKLDKGEEPKKCAIRELEEETGYIAKEISYLGKIATAPGFCDEIIYLYKATGLIKGKKNCDEDEFTELVVMSLEEVKEKIKSGEIIDTKTISVLAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAP8</accession>
    <name>A0A386PAP8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Lrp/AsnC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00320</name>
        <name evidence="3" type="ORF">EI377_10805</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00574"/>
    <dbReference type="EnsemblBacteria" id="AYE33003">
        <property type="protein sequence ID" value="AYE33003"/>
        <property type="gene ID" value="CP523_00320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61171">
        <property type="protein sequence ID" value="QAS61171"/>
        <property type="gene ID" value="EI377_10805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AsnC_trans_reg" evidence="1">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="160" mass="18186" checksum="4EC2873F3D72E708" modified="2018-12-05" version="1">MDDILEVLEKNSRYTDEEIAIMAGKTVEEVREAIREYEEKNIIAGYTTLINWENTGKETVTALIEVKITPQRGVGFDKVAERIYNFPQVKACYLMSSGGFDLTVIVEGKTMKEVAMFVSGKLAIQEYVTGTATHFVLKKYKDHGTIFKEKKSTDREVIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAQ6</accession>
    <name>A0A386PAQ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00390</name>
        <name evidence="6" type="ORF">EI377_10880</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00589"/>
    <dbReference type="EnsemblBacteria" id="AYE33013">
        <property type="protein sequence ID" value="AYE33013"/>
        <property type="gene ID" value="CP523_00390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61182">
        <property type="protein sequence ID" value="QAS61182"/>
        <property type="gene ID" value="EI377_10880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="6"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="388"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="470" mass="53446" checksum="361A90C69FA04CF0" modified="2018-12-05" version="1">MKEKLPLLNELIKYHKENNLILSMPGNKCGKGFLRDGIGENFVRNLGFLDITEVDPLDNLHCPEGVIKDSQELLSKYYKAKKGYFLVNGSSSGNLAAIFSAFNEGDEILVERNCHKSVYNAIILRKLKVIYIEGNIDENNGIFLPPNNDNIYKALKRSKNPKGIILTYPNYFGITYNLENILKNLKSSNLKIIIDGAHGAHFGVTDKLPKSIVNLSDYIVLSAHKTLPSLTQGAYLLTNNEDSNLEFYLKAFTTTSPSYLIMASLDYGRYYLDNYGKEDYEKLITLAEKWKENINSLKKVYILDKEDLIEGYNVDKSRYIITVPKGHNGHKLLAYLRKNKIQAEMSFQLGVVLMLSSFNTDEDFFKIFNAIKALDLSSIYEGKSFNKVYSFIGEKKMEPYEVFNKDSEEINIEDSEGRVCKDSIIPYPPGIPLLCAGEVINKEVILIIKDYIYNNINVIGIYKDKVNVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB01</accession>
    <name>A0A386PB01_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPF0122 protein CP523_00815</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_00815</name>
        <name evidence="5" type="ORF">EI377_11310</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0122 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674599.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02357"/>
    <dbReference type="EnsemblBacteria" id="AYE33095">
        <property type="protein sequence ID" value="AYE33095"/>
        <property type="gene ID" value="CP523_00815"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61265">
        <property type="protein sequence ID" value="QAS61265"/>
        <property type="gene ID" value="EI377_11310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00815"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00245">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40083">
        <property type="entry name" value="PTHR40083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="109" mass="13103" checksum="0410082EFD4F6DF3" modified="2018-12-05" version="1">MEDRVEISMLMDFYGTLLTDKQYKIMELYYNDDLSLGEIAELNNTSRQAIHDLIKRCYKQFLSYESRLNLLEKSLKKEKVILELLEDLKIKYSLSDKDYEKYKNTLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBG2</accession>
    <name>A0A386PBG2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exo-alpha-sialidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">LPXTG cell wall anchor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_01750</name>
        <name evidence="10" type="ORF">EI377_12270</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677334.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33273">
        <property type="protein sequence ID" value="AYE33273"/>
        <property type="gene ID" value="CP523_01750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61444">
        <property type="protein sequence ID" value="QAS61444"/>
        <property type="gene ID" value="EI377_12270"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004124">
        <property type="entry name" value="Glyco_hydro_33_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023364">
        <property type="entry name" value="Trans_sialidase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02973">
        <property type="entry name" value="Sialidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363010" evidence="6">
        <location>
            <begin position="27"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1296" mass="141784" checksum="DF3E0F7DC098277D" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBI2</accession>
    <name>A0A386PBI2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome C551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01810</name>
        <name evidence="3" type="ORF">EI377_12330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677301.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02389"/>
    <dbReference type="EnsemblBacteria" id="AYE33285">
        <property type="protein sequence ID" value="AYE33285"/>
        <property type="gene ID" value="CP523_01810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61456">
        <property type="protein sequence ID" value="QAS61456"/>
        <property type="gene ID" value="EI377_12330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025306">
        <property type="entry name" value="Zn-bnd_dom_prob"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13451">
        <property type="entry name" value="zf-trcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="51" mass="6148" checksum="00D974EE51A00AED" modified="2018-12-05" version="1">MEDKKIICKDCGKEFVFTVGEQEFYKEKGFDNEPVRCMDCRRARKAQNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBU1</accession>
    <name>A0A386PBU1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="1">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_02475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EC" id="7.2.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00472"/>
    <dbReference type="EnsemblBacteria" id="AYE33405">
        <property type="protein sequence ID" value="AYE33405"/>
        <property type="gene ID" value="CP523_02475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="849" mass="93550" checksum="0E740A6555930152" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBZ5</accession>
    <name>A0A386PBZ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02775</name>
        <name evidence="7" type="ORF">EI377_13300</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676974.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00961"/>
    <dbReference type="EnsemblBacteria" id="AYE33463">
        <property type="protein sequence ID" value="AYE33463"/>
        <property type="gene ID" value="CP523_02775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61634">
        <property type="protein sequence ID" value="QAS61634"/>
        <property type="gene ID" value="EI377_13300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="272" mass="31589" checksum="D7F4C9ACA7CF4BA1" modified="2018-12-05" version="1">MEAINKFYLEDGNLQSIENYTEDTKEKGRVIYEVLRVIDGIPLFLEDHIDRMAETFKLMDKSFVYTYEKISEFAMALIEANRVKNGNIKVTFDIKTDTMKVYSIKHSYPTEDMYINGVKSILYHGERVNPNAKVVDSDFRKKVTIEIEKANAFEAILIDNEGYITEGSKSNIFMVKDNILITPKQSKVLPGVTRKRIISIANREEIQFEERNISAKELKSIDAMFISGTSPKILPIFKIEDIDFNINNEIINIIKNKFNEEIHDYVNSRRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC17</accession>
    <name>A0A386PC17_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_02895</name>
        <name evidence="7" type="ORF">EI377_13420</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677012.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00985"/>
    <dbReference type="EnsemblBacteria" id="AYE33485">
        <property type="protein sequence ID" value="AYE33485"/>
        <property type="gene ID" value="CP523_02895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61656">
        <property type="protein sequence ID" value="QAS61656"/>
        <property type="gene ID" value="EI377_13420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="20392" checksum="A3DCCAD8406D241F" modified="2018-12-05" version="1">MSIKEVVLIGIAMAMDAFGLSISLGINPILKRKNKIGFILSFAFFQFLFIFIGGLVGVVFNTYIASIPNLVAGGVIGVIGIIMIIEGFKNEDRDDTFLIKKCMYIILGMSVSIDALVVGFTAFHHITSGIVLLLDSIIVGLITLLMCLIGFYMCRYIRRIGFISKYSGFFGGIILMIFAIKMIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCB1</accession>
    <name>A0A386PCB1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02500</name>
        <name evidence="3" type="ORF">EI377_13035</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673948.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33410">
        <property type="protein sequence ID" value="AYE33410"/>
        <property type="gene ID" value="CP523_02500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61584">
        <property type="protein sequence ID" value="QAS61584"/>
        <property type="gene ID" value="EI377_13035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="67" mass="7612" checksum="BBE7974993221965" modified="2018-12-05" version="1">MKETVNFFTDRKVLLGIGIGMVLSTILMFGYKHNGTLSNDKVEEKARALGMHYDDECKVIFKGDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCF9</accession>
    <name>A0A386PCF9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tellurium resistance protein TerC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">TerC/Alx family metal homeostasis membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00325</name>
        <name evidence="8" type="ORF">EI377_10815</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678128.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00575"/>
    <dbReference type="EnsemblBacteria" id="AYE33004">
        <property type="protein sequence ID" value="AYE33004"/>
        <property type="gene ID" value="CP523_00325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61172">
        <property type="protein sequence ID" value="QAS61172"/>
        <property type="gene ID" value="EI377_10815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="32659" checksum="9D169A32F443F28F" modified="2018-12-05" version="1">MKTKRSLLNLIFWILLAIIFNIYIYYLRGEKAAVEFLGGYIIEMSLSLDNLFLFLMIFESFGIPEAYQERVLKYGVLGAIILRLIFILLGVAIVNKFHFIIYFFGILLFFSGFKMILDRHSNMNFSNNPIIRLVGKIVPLTNTFHGDCFFVKINKIIYATPLFIILLIIESSDIIFALDSIPAIFSITTDIFLVYTSNIFAILGLRSMYYILARMNSMFKFMKYGVACILMFTGFKLMIMYFGIEISVVISVLIIMIILLSSILISLVFDDKNIKKHRYIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCK7</accession>
    <name>A0A386PCK7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">recA</name>
        <name evidence="11" type="ORF">CP523_00600</name>
        <name evidence="12" type="ORF">EI377_11090</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676351.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00651"/>
    <dbReference type="EnsemblBacteria" id="AYE33054">
        <property type="protein sequence ID" value="AYE33054"/>
        <property type="gene ID" value="CP523_00600"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61223">
        <property type="protein sequence ID" value="QAS61223"/>
        <property type="gene ID" value="EI377_11090"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00600"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="9">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="10">
        <location>
            <begin position="202"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="68"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="348" mass="37359" checksum="F0C441BF092081B0" modified="2018-12-05" version="1">MGNIDTDKLKAIENAMSQIEKQFGKGSVMRLGADSSLNVDAISTGCLDLDIALGIGGVPKGRIIEIYGPESSGKTTVALHIAAESQKAGGAVAFIDAEHALDPSYARNLGVDTESLIVSQPDTGEQALEIAEALVRSGAIDVIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTGTIQKTGCVAIFINQLREKVGVMFGNPETTTGGRALKFYASVRLDVRRIDSIKQGEGIVGNRTRVKVMKNKVAPPFKQAEFDIMYNEGISRTGNIVDVGVKEGIIQKSGAWFSYGDVRLGQGRENAKLYLKENEDVALDIENQIRSKHDLPLAVKPSVKKEEKVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCL3</accession>
    <name>A0A386PCL3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04060</name>
        <name evidence="3" type="ORF">EI377_14580</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676911.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02774"/>
    <dbReference type="EnsemblBacteria" id="AYE33703">
        <property type="protein sequence ID" value="AYE33703"/>
        <property type="gene ID" value="CP523_04060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61858">
        <property type="protein sequence ID" value="QAS61858"/>
        <property type="gene ID" value="EI377_14580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="51"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="26100" checksum="5712E925ED8A2B1B" modified="2018-12-05" version="1">MLSPTMAKIINILPDSLLIKVIKMTINGYLKKYANLDVKGMENIEKVEGAKIFICNHLSNADGLVLDKVLKEKYDPTFVAGVKLSNDPVTRLGTEIVKHINIKPNSADKEALTKMVKVVKEGGNLLLFPEGTRSRTSQMIEGKKGVLLIARLTKAEIVPIGMWGTEELLPISESGDMASEKFKDADVHVRFGEPITLPKKIEGESKHEFEERSMNYVMKSIANLLPEEYRGVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCQ3</accession>
    <name>A0A386PCQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I-B CRISPR-associated protein Cas7/Cst2/DevR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cas7i</name>
        <name evidence="3" type="ORF">CP523_01665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675698.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00885"/>
    <dbReference type="EnsemblBacteria" id="AYE33257">
        <property type="protein sequence ID" value="AYE33257"/>
        <property type="gene ID" value="CP523_01665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01665"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013414">
        <property type="entry name" value="Cas7/Cst2/DevR_sub_I-B/Tneap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010154">
        <property type="entry name" value="CRISPR-assoc_Cas7/Cst2/DevR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01905">
        <property type="entry name" value="DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02585">
        <property type="entry name" value="cas_Cst2_DevR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01875">
        <property type="entry name" value="cas_MJ0381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="291" mass="33101" checksum="75B9169E38E7E791" modified="2018-12-05" version="1">MEKKGLTASFIFEAESANYGEGVGNVTALKKISRGDGEAYSYISRQAIRYNIINQMGEDNTPLGLDGEVLQFHTDATIKDYPEIDFFGYMKTIKPIRTRSAVVRLSNAVALESFNADTEFLTNKGLLDRYNKDLKDKKNGGNIAQSEIHKSYYSYTITIDLDKVGIDENDNIEISNEEKAKRVNKLLDTILFLYRDIRGRRENLSPIFAIGGVYSIKNPFFENRLKIKNNSLRIETINSILDLNEDINNNTNIGLLKGIFNNDESIENALKPIEIGEFFKELKSKVTEYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCU5</accession>
    <name>A0A386PCU5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HAMP domain-containing histidine kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03570</name>
        <name evidence="6" type="ORF">EI377_14095</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677741.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02231"/>
    <dbReference type="EnsemblBacteria" id="AYE33610">
        <property type="protein sequence ID" value="AYE33610"/>
        <property type="gene ID" value="CP523_03570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61774">
        <property type="protein sequence ID" value="QAS61774"/>
        <property type="gene ID" value="EI377_14095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="126"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="337" mass="39266" checksum="92D4AC175E3AC566" modified="2018-12-05" version="1">MQLKDFIKERIVFILINIGILAFTAALLSILKVDGYAIIFILVLNFIGILIFHINEYLKKRKYYNEFLCNIEKLDKKYLISEVMEEGDFLEGKILYDIIRQTDKSMNDEVASLKINNNEYREYIELWVHEVKTPIATCKLLIENNPSEITKSINEEVEKVENYIEQALFYTRSNTLEKDYIIKEINIKNCINSVIRKNANILIEKGIKIKIEDIDRIVYTDIKWIKFILHQIISNSIKYMDKEISILNISCEEYKESIILHISDNGIGMNEKDVIKAFEKGYTGENGRKFGKSTGIGLYLCRKLSLKLGLSIKLKSEINKGTRVSILFPLNKMMIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCY8</accession>
    <name>A0A386PCY8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04875</name>
        <name evidence="3" type="ORF">EI377_15390</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675759.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33853">
        <property type="protein sequence ID" value="AYE33853"/>
        <property type="gene ID" value="CP523_04875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61999">
        <property type="protein sequence ID" value="QAS61999"/>
        <property type="gene ID" value="EI377_15390"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="96" mass="10877" checksum="9803920447194807" modified="2018-12-05" version="1">MKKSARREVSFINSIFYIIVSIFIISLEKLLSKNTTIKLSFTFSIVAILSYVLAFKIISPSFNSIKLGKLLFQVIPLFIGIIIVTSFILKILSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD51</accession>
    <name>A0A386PD51_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05205</name>
        <name evidence="4" type="ORF">EI377_15765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676238.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33915">
        <property type="protein sequence ID" value="AYE33915"/>
        <property type="gene ID" value="CP523_05205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62066">
        <property type="protein sequence ID" value="QAS62066"/>
        <property type="gene ID" value="EI377_15765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788344" evidence="2">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="147" mass="17071" checksum="C0E44603036AC821" modified="2018-12-05" version="1">MGIRRKRSLVVLFSIIFIFCFSNFRVVKAEIENDIKKEYYKVTTVDESRTKEFEQESYKGIINKEDNYSNLINKSDKISKNTFLSVFNNRDKEKSTDKMNKSENINKLLQSFGLPSTGIEDSYIIITVVIAIIIVSSVMFKEKKDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD78</accession>
    <name>A0A386PD78_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04315</name>
        <name evidence="3" type="ORF">EI377_14850</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33750">
        <property type="protein sequence ID" value="AYE33750"/>
        <property type="gene ID" value="CP523_04315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61907">
        <property type="protein sequence ID" value="QAS61907"/>
        <property type="gene ID" value="EI377_14850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04315"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="220" mass="25509" checksum="45586CF8C96CD596" modified="2018-12-05" version="1">MNKEFIEKYGYILLSICTAIGTLIFSKANIIIQILSIVVQVFINKYILKIFIEKSTIKYRKMKLPNVESLSINPKIDYFISLYLDIFLYCFIMYFIMVINIDGFSSFNKLNLKSPLSILLIVTIIGLGIYGIMGAEVQVIKDKDKIIYLLETTSPGRYTSTLSSRVGKFKDGIIIDDYIFYNDEILNSFKSEKELIIYLKNSRQIIIYDKRAINYLKEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDD6</accession>
    <name>A0A386PDD6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05755</name>
        <name evidence="2" type="ORF">EI377_00220</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34005">
        <property type="protein sequence ID" value="AYE34005"/>
        <property type="gene ID" value="CP523_05755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59374">
        <property type="protein sequence ID" value="QAS59374"/>
        <property type="gene ID" value="EI377_00220"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="25883" checksum="365A922805C916B6" modified="2018-12-05" version="1">MEHLPQIANQVKNGGKVEKIVESIKASKGAAEAVSKLKYTLKYSIDELAFQIKKVVSLGDNPVVVLDGGFQYAINTAEDVPAHFRPQFKEVVENIWKYSGKTADEIIATGKKIVPNKGYNTFKELKEALGLPGDDSQWHHIVEQSQIKPTRAGFAPADINNLDNIISMPSGSDSIHSKISGYYSSKPPFTNGLTVRDWLSTKSFDEQFKYGIEMLQQYGNVIPTSKGWVFNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDG9</accession>
    <name>A0A386PDG9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sel1 repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05965</name>
        <name evidence="2" type="ORF">EI377_00445</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01895"/>
    <dbReference type="EnsemblBacteria" id="AYE34045">
        <property type="protein sequence ID" value="AYE34045"/>
        <property type="gene ID" value="CP523_05965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59417">
        <property type="protein sequence ID" value="QAS59417"/>
        <property type="gene ID" value="EI377_00445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="847" mass="98473" checksum="0CE83FB7447BF701" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDW8</accession>
    <name>A0A386PDW8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_06970</name>
        <name evidence="6" type="ORF">EI377_01455</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01009"/>
    <dbReference type="EnsemblBacteria" id="AYE34215">
        <property type="protein sequence ID" value="AYE34215"/>
        <property type="gene ID" value="CP523_06970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59580">
        <property type="protein sequence ID" value="QAS59580"/>
        <property type="gene ID" value="EI377_01455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="185"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="33846" checksum="45A4C1BAAC93BDBC" modified="2018-12-05" version="1">MGNTRYLINDKNIYNCKYELLYISKSKYENDWHSTAHFHPFTEIFFIINGEGAFHLDDKDVKVKQWDLIIINPNCLHTEKSITKDNPLEYIVLGIDNLLLNFPDTYSLTNNINLKKLYKIIDFTSNKDYILHYLNCLIQEVESKDYNYEMACKNILTLLIIHIIRSIPSLLLVEEPQEKLNLECVKIKNYIDSHYSENITLDILSDMSYMNKFHLVHTFTKQIGISPINYVINKRIEESKNLLATTNYSIRDIASIVGFSNSSYFSQAFKKVTGKSPKEYRVDKLHSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE49</accession>
    <name>A0A386PE49_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endopeptidase La</fullName>
            <ecNumber evidence="3">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lonC</name>
        <name evidence="6" type="ORF">CP523_07540</name>
        <name evidence="7" type="ORF">EI377_02230</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673814.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01117"/>
    <dbReference type="EnsemblBacteria" id="AYE34305">
        <property type="protein sequence ID" value="AYE34305"/>
        <property type="gene ID" value="CP523_07540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59699">
        <property type="protein sequence ID" value="QAS59699"/>
        <property type="gene ID" value="EI377_02230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014252">
        <property type="entry name" value="Spore_LonC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02903">
        <property type="entry name" value="spore_lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="4">
        <location>
            <begin position="178"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="5">
        <location>
            <begin position="458"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="632" mass="70140" checksum="B9F3823CAF1737DA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE77</accession>
    <name>A0A386PE77_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">gyrB</name>
        <name evidence="12" type="ORF">CP523_07690</name>
        <name evidence="13" type="ORF">EI377_02380</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673870.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01147"/>
    <dbReference type="EnsemblBacteria" id="AYE34333">
        <property type="protein sequence ID" value="AYE34333"/>
        <property type="gene ID" value="CP523_07690"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59729">
        <property type="protein sequence ID" value="QAS59729"/>
        <property type="gene ID" value="EI377_02380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07690"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="420"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="637" mass="71371" checksum="7BC8234E0AE0F4EA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEG7</accession>
    <name>A0A386PEG7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675389.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01464"/>
    <dbReference type="EnsemblBacteria" id="AYE33644">
        <property type="protein sequence ID" value="AYE33644"/>
        <property type="gene ID" value="CP523_03750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="186"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="394" mass="43186" checksum="E70B5F9C297D58BE" modified="2018-12-05" version="1">MNKFMEQAKLIKDDMIVYRRTIHSNPEVGSELLKTKTYVMDKLREFGYDPKEICESGIVATIKGNKPGKTFLLRADMDALPMKEATECDFKSINGNMHSCGHDMHTAMLLGAAKLLKENQDEIEGTVKLVFQPDEEGFTGAKKMIKAGVLEDPKVDAAMAMHVHSGTPSNVILCGLGTSIAGCSIFRIVVKGTGCHGAMPETGVDPINIASHIYISLQEIISREISATQSAVVTIGKFIGGDAPNIIPQEVVMEGTIRTLDKKVEEFIFNRMNDIVTYTAKMFRGEAELIKLSSVPPLVNNNNLAHEITGYMKELVGEKSVILFESGGMGSEDFASYSYEVPSLYVMLGAGSKEENPLFGEPMHSEKVVFNEEILSTGAAMHAYSAIMWLKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEQ9</accession>
    <name>A0A386PEQ9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor SigS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sigH</name>
        <name evidence="7" type="ORF">CP523_08880</name>
        <name evidence="8" type="ORF">EI377_03635</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678119.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02716"/>
    <dbReference type="EnsemblBacteria" id="AYE34523">
        <property type="protein sequence ID" value="AYE34523"/>
        <property type="gene ID" value="CP523_08880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59925">
        <property type="protein sequence ID" value="QAS59925"/>
        <property type="gene ID" value="EI377_03635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014218">
        <property type="entry name" value="RNA_pol_sigma-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016371">
        <property type="entry name" value="RNA_pol_sigma-H_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002939">
        <property type="entry name" value="RNA_polymerase_sigma-H_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02859">
        <property type="entry name" value="spore_sigH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="6">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="24856" checksum="6B6B0595C7979013" modified="2018-12-05" version="1">MDNKGYVVETFTNFEDKLDEEIVVESQKGNVRAQEYLISKYENFVKSKSKSYFLIGADKEDIYQEGMIGLYKAIRDFKPDKLTSFKAFAELCVTRQIITAIKTATRQKHIPLNTYVSLNKPIYEEESDRTLLDIISGFRISDPEELIIGEEQMKRIEGEMQKVLSSLEMEVLQSYLDGKSYQEIACDLDRQSKSIDNALQRVKRKLEKCLYTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF67</accession>
    <name>A0A386PF67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_08415</name>
        <name evidence="9" type="ORF">EI377_03160</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01624"/>
    <dbReference type="EnsemblBacteria" id="AYE34450">
        <property type="protein sequence ID" value="AYE34450"/>
        <property type="gene ID" value="CP523_08415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59853">
        <property type="protein sequence ID" value="QAS59853"/>
        <property type="gene ID" value="EI377_03160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="335" mass="36461" checksum="088E9D1C59A8583B" modified="2018-12-05" version="1">MKKKRFKIVLLILIALLLISFVVTLCWGTYNVSPLEVIKTLLGNGSKLQNTAVLNIRLPRLLVGSFVAICLSTAGAILQTVTKNDLADTGIIGINAGAAVAAIIFITYQTANYYSQLGQFSIFVLPFMAIVGAGITSFIIYMLSSRNGLRPKRLLLIGIGLNAGLNAFITFFTFRGGVGDYNRVLVWTSGSLWGSGWSYAKVIIPITVVMFILVLLNHKKLDVLNLSDELAISLGLNLEKERKKFLKYAVILAGTATAFAGNIGFLGLISPHIAKKLVGPYHKNFIIISAIISVIIILFADAVSRNLFSPIEIPVGITVSIFGVPYFIYLMIKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF68</accession>
    <name>A0A386PF68_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gx transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Heptaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09990</name>
        <name evidence="3" type="ORF">EI377_04775</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676553.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00327"/>
    <dbReference type="EnsemblBacteria" id="AYE34705">
        <property type="protein sequence ID" value="AYE34705"/>
        <property type="gene ID" value="CP523_09990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60106">
        <property type="protein sequence ID" value="QAS60106"/>
        <property type="gene ID" value="EI377_04775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014535">
        <property type="entry name" value="Hpre_diP_synt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027391">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="170" mass="18357" checksum="88F569B33F9B0154" modified="2018-12-05" version="1">MRKTNKMVYIGLLVAQALVLHIVERSIPVPFVTPGAKLGLANLITVIALYTLPKERDAFLVLFLRIALGTMFGGNLSSFMYSAVGGFLSFLSMIFVKNILKDKVSIIGVSSAGAIFHNLGQIIVAAIIVQNIAVTLYLPILSVISIVTGIFIGVSANYIVKHLDKLQILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF69</accession>
    <name>A0A386PF69_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">LacI family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03895</name>
        <name evidence="6" type="ORF">EI377_14420</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675509.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01549"/>
    <dbReference type="EnsemblBacteria" id="AYE33671">
        <property type="protein sequence ID" value="AYE33671"/>
        <property type="gene ID" value="CP523_03895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61830">
        <property type="protein sequence ID" value="QAS61830"/>
        <property type="gene ID" value="EI377_14420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="348" mass="39872" checksum="9393EC43FDB90255" modified="2018-12-05" version="1">MGKGKKVTINDIATKASTSKTTVSFYLNGKFDKMSPDTKRRIEQAINETKYSPSIMARSLKSKKSNLIGVVVADITNPFSNNIVKGIDDVARKEGYQILVGSSNFEYNNEKKYIDRMLDMGVDGFIVQPTLNFNKLIKTIQDRGKKIVVLDSVNKEFKGRWVKTNNYDITSKATRELFKEGYEEFILVTEDPKLLMARMERKNGFEDSLKELGAKYSTLIIENDINYEDLAKLLREKINKDKKTLIFAINGRTLQKVFMTSKKEKWNVPNEIGIIGFDNWDWTFYASPSVTTIDQPTYEEGTYAASILIDMLQEKGDIEESTIFECSINWAESTNINEKPLEHREFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB8</accession>
    <name>A0A386PFB8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prmA</name>
        <name evidence="3" type="ORF">CP523_02250</name>
        <name evidence="4" type="ORF">EI377_12770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674021.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00517"/>
    <dbReference type="EnsemblBacteria" id="AYE33366">
        <property type="protein sequence ID" value="AYE33366"/>
        <property type="gene ID" value="CP523_02250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61536">
        <property type="protein sequence ID" value="QAS61536"/>
        <property type="gene ID" value="EI377_12770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="313" mass="34863" checksum="6209F505CFDC222F" modified="2018-12-05" version="1">MEGTWIEVRVITKSEALEPISGIFYGLDCKGIAIEDPNDILGREQGPLTWDFADINVLEHKGTVAVVKAYFAEEDNIEEILVYINEKINELREIGIDVGEGKVENEKMFEEDWANNWKKYYKPTKVGDKIVVKPIWEEYEIKDNELLVELDPGMAFGTGTHETTRMCIQALERYVKEDSTVFDVGCGSGILAISAAKLGAKLAVGVDLDPVAVESAKENVGFNNLDNIEILYGNLVEVIDGKADIVVANIIAEIICILTEDVKRVINDGGYFITSGIIHDRVEMVTNKLEETGFEVLEINKDGEWNCIVAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF9</accession>
    <name>A0A386PFF9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01575</name>
        <name evidence="2" type="ORF">EI377_12095</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675669.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33242">
        <property type="protein sequence ID" value="AYE33242"/>
        <property type="gene ID" value="CP523_01575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61414">
        <property type="protein sequence ID" value="QAS61414"/>
        <property type="gene ID" value="EI377_12095"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="64" mass="7427" checksum="157FBAE76D44DA64" modified="2018-12-05" version="1">MNNSANQDYIYFGLTTKECIDINDKEKTPKNNFNFSANDNCQEFYINLKSLEISKTLKLTLVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK2</accession>
    <name>A0A386PFK2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10705</name>
        <name evidence="3" type="ORF">EI377_05490</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674131.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34835">
        <property type="protein sequence ID" value="AYE34835"/>
        <property type="gene ID" value="CP523_10705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60230">
        <property type="protein sequence ID" value="QAS60230"/>
        <property type="gene ID" value="EI377_05490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362710" evidence="1">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="219" mass="25155" checksum="11B58FE3E26D8E21" modified="2018-12-05" version="1">MSTKIISCLLSGILVMSLVSCSSEPEKKVKESKPKAAVEEKQLEGKWAKNYSKDEVTKLNNEILTRIEEKTELFELEYEKKEEVKEENGETVNSNYIYVDNLNPEPNRLESMYYGFKVYGSDMSKGQLILKIGFNLDKKIIKEEGEFDFGSTSIAEYSQDMTGVEDRDYSDLNQKIYDIIKGEKAEGTIENNLDGLLETISIKDNILLYKLESKKYNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR3</accession>
    <name>A0A386PFR3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Macrolide ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00365</name>
        <name evidence="6" type="ORF">EI377_10855</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00583"/>
    <dbReference type="EnsemblBacteria" id="AYE33009">
        <property type="protein sequence ID" value="AYE33009"/>
        <property type="gene ID" value="CP523_00365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61178">
        <property type="protein sequence ID" value="QAS61178"/>
        <property type="gene ID" value="EI377_10855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="25715" checksum="4925FC55AB87E9BD" modified="2018-12-05" version="1">MKKYIEFIDVKKIYKMGEVEIKALNGVDFNINKGEFVVVAGASGAGKSTILNILGGMDIASSGKVIVDGKDISKYSSKELITYRRYDIGFVFQFYNLVQNLTALENVELATQICKDSLNVSETLDAVGLSNRKNNFPAQLSGGEQQRVAIARALAKNPKLLLCDEPTGALDYNTGKSILKLLQDTCRKMGMTVVIITHNLALTPMGDKVIKVKNGKIESIVINENPVPVERIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU6</accession>
    <name>A0A386PFU6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676323.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00634"/>
    <dbReference type="EnsemblBacteria" id="AYE33039">
        <property type="protein sequence ID" value="AYE33039"/>
        <property type="gene ID" value="CP523_00525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="229" mass="26866" checksum="FC348EB532D8DCCF" modified="2018-12-05" version="1">MVLDSDFIKQYEKIASKDIELALKFCFDEFNQKKDPDILIYIGESYMVDEKFDLAVNYINKAIESNCKNRLLAYSLIGESLFYLGLYEKSKEYFFKVLDLDKESFFATIYLIDINLSEKNYKLAKKIGEDFLEYSNLNSEDKSFLIAKIAWIQLRYTKEYTESINNVKEALSINKNCGNAYIVLGFYNLSLERYKEAMRSFKNAIKLGEECEEVYYGIKECTMKMGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX3</accession>
    <name>A0A386PFX3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05185</name>
        <name evidence="3" type="ORF">EI377_15745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676229.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33911">
        <property type="protein sequence ID" value="AYE33911"/>
        <property type="gene ID" value="CP523_05185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62062">
        <property type="protein sequence ID" value="QAS62062"/>
        <property type="gene ID" value="EI377_15745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045620">
        <property type="entry name" value="DUF6442"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20040">
        <property type="entry name" value="DUF6442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="103" mass="11645" checksum="1BF3E1F69225274D" modified="2018-12-05" version="1">MNKEEILSKSRQENKDEGVEFIENEGRKVGYNVFCIVFIFIVVFNSFIGEQSYAVFALFSVFMAGESIPKYKLTHKKIDLIIMIVSAIAAIISLVSFVLASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFX7</accession>
    <name>A0A386PFX7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11255</name>
        <name evidence="2" type="ORF">EI377_06065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673231.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02808"/>
    <dbReference type="EnsemblBacteria" id="AYE34943">
        <property type="protein sequence ID" value="AYE34943"/>
        <property type="gene ID" value="CP523_11255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60337">
        <property type="protein sequence ID" value="QAS60337"/>
        <property type="gene ID" value="EI377_06065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="246" mass="29360" checksum="A81D98A7317594E6" modified="2018-12-05" version="1">MKPYEKKYVIEKIREYNEKISLGKIGDFEIKKIKWLEGIIKGYMYEKEGVIKEDILELHGPKNIWMRITPLEIESSYMPISRAVGKVGIVGLGLGYVVQEMAKKDSVKEIIVYEIDKDVIELYKNNFKENEKIKILNEDAFKAESQDFDFFYVDIYEYKLTKKVVKDYIHFNNLHRIEEYSFWGMEHFLLSCRYEEIVWVFIPENWMEMSREIFEALKEEGLLTYYKKLDTKLVSSVLSDFKVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG26</accession>
    <name>A0A386PG26_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11525</name>
        <name evidence="3" type="ORF">EI377_06340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673325.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02863"/>
    <dbReference type="EnsemblBacteria" id="AYE34993">
        <property type="protein sequence ID" value="AYE34993"/>
        <property type="gene ID" value="CP523_11525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60386">
        <property type="protein sequence ID" value="QAS60386"/>
        <property type="gene ID" value="EI377_06340"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="146" mass="17473" checksum="191B08797E5CFE6C" modified="2018-12-05" version="1">MRYEEMKKEHIEVLTKLYINAFNKEPWNDKWTTEIVLKRLNQMINCEGFYGIVAYEEDKPVGMILGNHEYYYYGMQFNIKEFCVDTTIQSRGLGTKVLEEFIERLKSRGIDEIILLTTKSEKAEGFYKRRGFDTIENMVTMRKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG41</accession>
    <name>A0A386PG41_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06915</name>
        <name evidence="3" type="ORF">EI377_01400</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673637.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00996"/>
    <dbReference type="EnsemblBacteria" id="AYE34204">
        <property type="protein sequence ID" value="AYE34204"/>
        <property type="gene ID" value="CP523_06915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59569">
        <property type="protein sequence ID" value="QAS59569"/>
        <property type="gene ID" value="EI377_01400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="36116" checksum="DD095DB8E3DDF969" modified="2018-12-05" version="1">MKESKGISIDLVKGTFSDYIIRDKNSIVVGRFTILELDKDNKKCNVRLKFYRYNDPELLSETVSNILRAIFKDSSIYKANFIVNENANFKVFIDLGFVLEGIFSDNLFVNGHFMDELSFGINRSDYNNSFVTSIIRLKGENIEIRNLTPENAEDLLDYYIRNKEHLDPYEPSRDDSFYTYETQRDILIESYRQLINGTSYDLGIYKDEKLIGKAKLSNIVYGIFKSAILGYSIDREYQGKGYMKEAVRLILDYSKSELELHRIEASVLLDNKRSKAVLLGCGFKEIGINEKYLFINGSWKDHLTLYKILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG51</accession>
    <name>A0A386PG51_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01008"/>
    <dbReference type="EnsemblBacteria" id="AYE34214">
        <property type="protein sequence ID" value="AYE34214"/>
        <property type="gene ID" value="CP523_06965"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="297" mass="33565" checksum="1B0C880BFFEBDE54" modified="2018-12-05" version="1">MGRKNTSKKLFISLSVIPAIVLFIVFMVIPTLNVFWMSLFKWGGLSNNKKFVGLDNFTILFKDENFIRSFQNTLFLLVIVTIITLILAITSAAVLVREDTKFKNFFRIVFYFPNILSVVVISAIFSAILDPRQGIINATLDALSLESFKRMWLGDQKVVIWCIALAMIWQAVGYYMVMYMASMSSIPSSLYESADLEGATRSQQFFQITLPLIWNTIRTTLTFFIISTINLSFLFVKVMTAGGPDGASDVFLNYMYKQAYSNSAYGYGMAIGVVIFIFSFGLSLIISKATKRDVIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG54</accession>
    <name>A0A386PG54_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_03040</name>
        <name evidence="12" type="ORF">EI377_13540</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678434.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01769"/>
    <dbReference type="EnsemblBacteria" id="AYE33512">
        <property type="protein sequence ID" value="AYE33512"/>
        <property type="gene ID" value="CP523_03040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61678">
        <property type="protein sequence ID" value="QAS61678"/>
        <property type="gene ID" value="EI377_13540"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="153"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="315"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="466" mass="50348" checksum="711009B9A4B10456" modified="2018-12-05" version="1">MISFLISLVLLVVGYFTYGKFVEKVFGTDDSFKAPSETMQDGVDFVPMSWPRIFLIQFLNIAGLGPIFGAIAGALWGPAAFLWIVFGCIFAGAVHDFFTGVLSMRNNGASVADLVGKYLGDIPRKIMVVFSVVLLVLVGVVFLTGPADLLKTLTGIDRNIFIVIIIIYYISATVLPIDKIIGKIYPLFGACLLIMAVGIGVGILIEGYTIPEIQFVNFHPKGTPIFPYLFITIACGAISGFHATQSPIMARCVRKESEARKVFYGAMIAEGVIALIWAAAAMSFFGGTEGLNTALANGGPATIVNTISNSLMGKIGAILAILGVVACPITSGDTAFRSARLTIADTMGMKQDKFANRFKIAIPLFAVGIALTFIDFAIIWRYFSWANQTLAMIMLWAASAYLVQAKKNYWICAVPAVFMSAVTSAYILQAPEGFKLAAGISNIVGIIFSLVLFVIFIRYTRKNQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG77</accession>
    <name>A0A386PG77_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AraC family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08400</name>
        <name evidence="3" type="ORF">EI377_03145</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674790.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01621"/>
    <dbReference type="EnsemblBacteria" id="AYE34447">
        <property type="protein sequence ID" value="AYE34447"/>
        <property type="gene ID" value="CP523_08400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59850">
        <property type="protein sequence ID" value="QAS59850"/>
        <property type="gene ID" value="EI377_03145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="234"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="334" mass="38289" checksum="CC4E96D9699D9625" modified="2018-12-05" version="1">MVSKTTKEFQSKVLNKMTFKAYPKENYTIYKNKDNSDLGYFIKYSRDGYYDFGIGDYSISSNFTLSFEHKEELMRFGTVYIGETTFKIENNPVSSFSPSSFFVVEKEIKGKQAWKKGQHFHGAEITIYKKYFDEVIKPNFSNTIDLDSFVKNYTYLYLPLEIASIIQNLRSLSEANRLTSIYLESKILESIALLSNEVYSSCENAFSNQLNYGNIKIGKNRFITLTASDANAIQKAYDILTKEACNPPTIKNLSKMVFLNEQKLKAGFSAKYHMSISEYTNSIRMTMAQNLLSTTDLSINEIAKAVGYNYSGNFVKMFKKVHGKTPLAFRKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG92</accession>
    <name>A0A386PG92_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07220</name>
        <name evidence="3" type="ORF">EI377_01975</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673735.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01061"/>
    <dbReference type="EnsemblBacteria" id="AYE34254">
        <property type="protein sequence ID" value="AYE34254"/>
        <property type="gene ID" value="CP523_07220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59661">
        <property type="protein sequence ID" value="QAS59661"/>
        <property type="gene ID" value="EI377_01975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="209" mass="24490" checksum="70AEF0A9AA842752" modified="2018-12-05" version="1">MGNVIYRELVREDYSRVKELIGDAFGFNNFIKDKGFLDLVLNIYLQDCILASSFSKVAEKDNKVIGFILGDSKKDKHRLRKSHNIISIAATSFKLIISNKENKKALKEFSKISDTYKEIIRGKKEKFQGCIQLFIVSKESRGLGVGKTLVNYLFNYMKSMEVKSLYLYTDTRCNYGFYDSQNFKRLIEKEIRFNSFNEKLNIFVYEYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA5</accession>
    <name>A0A386PGA5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vancomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04025</name>
        <name evidence="5" type="ORF">EI377_14545</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676923.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33696">
        <property type="protein sequence ID" value="AYE33696"/>
        <property type="gene ID" value="CP523_04025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61851">
        <property type="protein sequence ID" value="QAS61851"/>
        <property type="gene ID" value="EI377_14545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038054">
        <property type="entry name" value="LD_TPept-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007391">
        <property type="entry name" value="Vancomycin_resist_VanW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04294">
        <property type="entry name" value="VanW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="3">
        <location>
            <begin position="389"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="469" mass="52359" checksum="5E8372A4D77DBB03" modified="2018-12-05" version="1">MVDDRNKTEKRNYKNFISENKKSIYISLAIIITIITVGFIYIFSVKSEVESWQSKIYPNVTVHGVDIGGLTKEEANLKLKEELSSPIMDKILKVVVDDKEIDLKYSEVNPVYDVESITNEAFSLGKEGSLFEKKKLISKGINKELDAKITYDENELKKFEEKVKSEVNVNAKDATISINGGNISVDAEVAGKKINDDELHKKLVESINGNPSEEIQLKFTLEESQAKVKESDLKKITGKISFFTTSYTDTGDGRVTNMNIALKAVNGTVLMPGEEFSYNNLVGDTTPDKGYQKANTYIGNEIVPDYGGGICQVSTTLYRAVMGANLRSTERANHSLTVSYSEPGLDATVAYGVVDYKFVNTYDFPVYIEGYISDGTIGFNIYGNKEALGGKTYKLVNEVVEKYEPQVKYEDNPSLKEGEQRVKVNGMPGYKANSYQITYENGVEVKKEKISTDVYKTTDTIIERGTKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC5</accession>
    <name>A0A386PGC5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05270</name>
        <name evidence="2" type="ORF">EI377_15830</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676266.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01843"/>
    <dbReference type="EnsemblBacteria" id="AYE33928">
        <property type="protein sequence ID" value="AYE33928"/>
        <property type="gene ID" value="CP523_05270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62079">
        <property type="protein sequence ID" value="QAS62079"/>
        <property type="gene ID" value="EI377_15830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="24730" checksum="B8D9173A3D06DBB4" modified="2018-12-05" version="1">MTKLYLTRHGETEWNIQGIMQGWGDSPLSELGIKQAEWLQERIKDTPIDVIYTSPIGRAYNTAKIVRGDKEIEIVPHDGLKEIRVGNWEGLNQEELKELDIENYDNFWNTPSKYIPTGNGETFMEVKERTFAAVNEILQKEKGKNILIVTHTVALKTFLVALESKDIDTLWEPPFIKQTSLTEIDFNDEGYEFVLTACMKHHKYSKKEYNEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGC6</accession>
    <name>A0A386PGC6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS sugar transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12245</name>
        <name evidence="7" type="ORF">EI377_07070</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673590.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03004"/>
    <dbReference type="EnsemblBacteria" id="AYE35125">
        <property type="protein sequence ID" value="AYE35125"/>
        <property type="gene ID" value="CP523_12245"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60517">
        <property type="protein sequence ID" value="QAS60517"/>
        <property type="gene ID" value="EI377_07070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12245"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363064" evidence="4">
        <location>
            <begin position="26"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="103" mass="11214" checksum="6D80A31B8F07587C" modified="2018-12-05" version="1">MVRILLCCAAGMSTSLLVSKMEESADKKGIESKIWAVPVGDLENHIKDADVVLVGPQIRFKLKYVNTLAEQCSIPASLINTVDYGRVDGEKVLNLALDLINRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI1</accession>
    <name>A0A386PGI1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03800</name>
        <name evidence="4" type="ORF">EI377_14335</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675473.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01532"/>
    <dbReference type="EnsemblBacteria" id="AYE33652">
        <property type="protein sequence ID" value="AYE33652"/>
        <property type="gene ID" value="CP523_03800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61814">
        <property type="protein sequence ID" value="QAS61814"/>
        <property type="gene ID" value="EI377_14335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03800"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase_6" evidence="2">
        <location>
            <begin position="251"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="424" mass="49908" checksum="18DEF6711AE2A30E" modified="2018-12-05" version="1">MRLWFKDLIEFFKSKKKFFSIFLNIFLILVLFISFFYSLSRTNNLILVPSCQFEENIQYEATTNVGTFITDGEEPNEDEIIKFFNELFTTRNKAFLTGNVADLYKFYDTSHTYSKYSLLHEFKRIAYLRDWANERNISFSNISSTPKIRDIKINNSTYSIVLREEYKFDYFYKDTPDINNEFGVSLLHNVDLKKMGNSFIVQKDYYLDCFQEGLKDYKFDLTEKQIPLTKFKAYNVNFNRNNLEFNTNKFYDRKAAVNYANKYCGISWANDNNSRYNNNYYVYTASCGNCTNFISQCLSDKNEGGKLKQDKIWLYETKHSKPPTASETWINSDKLINYLLSTKRSTLINSGNFENLMSNFNNLQHGDLISYNINNSIEHTAIVTDFDNKGYPLVNSNSIDKYKFPFDLGWSNDDITFNLLSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ1</accession>
    <name>A0A386PGJ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_01890</name>
        <name evidence="11" type="ORF">EI377_12395</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678293.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01170"/>
    <dbReference type="EnsemblBacteria" id="AYE33299">
        <property type="protein sequence ID" value="AYE33299"/>
        <property type="gene ID" value="CP523_01890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61468">
        <property type="protein sequence ID" value="QAS61468"/>
        <property type="gene ID" value="EI377_12395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="Type_1_exporter"/>
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    </dbReference>
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        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
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            <end position="74"/>
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            <begin position="240"/>
            <end position="261"/>
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        <location>
            <begin position="17"/>
            <end position="299"/>
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            <begin position="332"/>
            <end position="565"/>
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    <feature type="binding site" evidence="6">
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            <begin position="364"/>
            <end position="371"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
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            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE33299.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS61468.1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="573" mass="65148" checksum="570216CB6D1BCC08" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
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    <name>A0A386PGK7_CLOSE</name>
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            <fullName evidence="2">Histidine kinase</fullName>
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    </protein>
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        <name evidence="9" type="ORF">CP523_12605</name>
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        <name type="scientific">Clostridium septicum</name>
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">DSM 7534</strain>
        </source>
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            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <comment type="catalytic activity">
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        </reaction>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="EI377_07510"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
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    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
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        </location>
    </feature>
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            <end position="670"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35193.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS60597.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="670" mass="76809" checksum="9511F8B540B7F4C8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN0</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CP523_04565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675837.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33796">
        <property type="protein sequence ID" value="AYE33796"/>
        <property type="gene ID" value="CP523_04565"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="101" mass="11644" checksum="9055B6D91895D7C2" modified="2018-12-05" version="1">MNKITVLLFGTTIQMCITFIILSCIINISFIKKIKKISEIKNIIFGLHLTLIGILTFYLTHTYIFTSMFWSIAMYFLPIYIITTGFMMSLVGYFANLNHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY2</accession>
    <name>A0A386PGY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11795</name>
        <name evidence="9" type="ORF">EI377_06615</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
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            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673407.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02917"/>
    <dbReference type="EnsemblBacteria" id="AYE35040">
        <property type="protein sequence ID" value="AYE35040"/>
        <property type="gene ID" value="CP523_11795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60433">
        <property type="protein sequence ID" value="QAS60433"/>
        <property type="gene ID" value="EI377_06615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="96" mass="11120" checksum="46DF817BB692E2B7" modified="2018-12-05" version="1">MKKRFFKNSDSRKISGVCAGLSEYFDIDVTIVRLITFSLILFTNIFWGIIFYFILSCILPDKSELDFNNKTSESETIIQDSEIINETKRDGGYDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH05</accession>
    <name>A0A386PH05_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02805</name>
        <name evidence="6" type="ORF">EI377_13330</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676985.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00967"/>
    <dbReference type="EnsemblBacteria" id="AYE33469">
        <property type="protein sequence ID" value="AYE33469"/>
        <property type="gene ID" value="CP523_02805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61640">
        <property type="protein sequence ID" value="QAS61640"/>
        <property type="gene ID" value="EI377_13330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="141" mass="15787" checksum="F37C8587EFAB2497" modified="2018-12-05" version="1">MKKISIIYWSNGGNVEVIANAIAESAQKNEAEVTMKHVVDATVEDVTEADAVAFGSPSMDNNRIEQQEMEPFINQFKLIQNHQKKLVLFGSYGWDDGKFMVDWIERMKDYGFNVVGSLAVKESPSDAELLEAAKLGEELTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH08</accession>
    <name>A0A386PH08_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Capsular biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_05100</name>
        <name evidence="10" type="ORF">EI377_15660</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676200.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01810"/>
    <dbReference type="EnsemblBacteria" id="AYE33896">
        <property type="protein sequence ID" value="AYE33896"/>
        <property type="gene ID" value="CP523_05100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62047">
        <property type="protein sequence ID" value="QAS62047"/>
        <property type="gene ID" value="EI377_15660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS62047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="225" mass="25555" checksum="B81B1C296F725CEF" modified="2018-12-05" version="1">MEEQTIRVQDLFDALKKRWRLIVIITLVSVILASILSFFIIKPQYEASTKIFIGKEDTESQGYNQNDVLMYQKLMKTYSEAIKTKDLVSKALDKGNIKLDESKVLKNLTVVPVADTQILQIKFRSKNREEAKNVIKVVTDQFIATSKELVPNGNIKIIEQVSLPEKPVSPNKKMNIAIAFLLGIMIGTGLCLLLEFMDNTFKTKEQLERELDIPVIGVIPKVENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH46</accession>
    <name>A0A386PH46_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">bioD</name>
        <name evidence="7" type="ORF">CP523_06935</name>
        <name evidence="8" type="ORF">EI377_01420</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673644.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01001"/>
    <dbReference type="EnsemblBacteria" id="AYE34208">
        <property type="protein sequence ID" value="AYE34208"/>
        <property type="gene ID" value="CP523_06935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59573">
        <property type="protein sequence ID" value="QAS59573"/>
        <property type="gene ID" value="EI377_01420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06935"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="25802" checksum="CFAE94E047C2F754" modified="2018-12-05" version="1">MRKSIFITGTDTDVGKTFVASLIVKTLRDNGVEAGYFKGVLSGAIKEDNKLIPGDAKEVCSLSGLNEDYENLVSYTLENPYSPHLASRIEGIDINIEKIKSDYKKMKDKYELLVVEGSGGIICPINITDTKTILLEDIIKELELSTIVIARAGLGTINHTILTIKYLEAEGIKVNGVILNGYNPQNIIHKDNKDIIRHLTGINRILTIPFVEKEKDNVDNLINFNMLISLING</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH67</accession>
    <name>A0A386PH67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13850</name>
        <name evidence="4" type="ORF">EI377_08745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02051"/>
    <dbReference type="EnsemblBacteria" id="AYE35423">
        <property type="protein sequence ID" value="AYE35423"/>
        <property type="gene ID" value="CP523_13850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60811">
        <property type="protein sequence ID" value="QAS60811"/>
        <property type="gene ID" value="EI377_08745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="62"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="325" mass="36783" checksum="980A8DAD3C4AECFC" modified="2018-12-05" version="1">MKIAVRGGHNFLAKGASVLIDETVEDRKVKDFVIEGLRGLGHEVLDVTPPDMDSDSDLVYGVSKANDWNADIFISIHFNKAYDSYNGKIGTETWVYSKNDNYNDEEYAQKIVNSIGNLGFKNRGVKEKKDLYELKATKMPSIIVEVCFVEATEDVALYRKLGQNKIAEAIVLGITGKNIEQPVQLAIGMRVALDEPNHITIDSNKLKVRGWALNHTKLEILIDNVSYGTVETGQKREDVYKAYPQYNNHFSGYEKTLEFTELEKGQHKCTVRATDNNKIIEVTKTFTASKSISNDNKVLKKDNEILRKENKELKEKMSKIKNIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE1</accession>
    <name>A0A386PHE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TrpR-like protein YerC/YecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09290</name>
        <name evidence="2" type="ORF">EI377_04035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34604">
        <property type="protein sequence ID" value="AYE34604"/>
        <property type="gene ID" value="CP523_09290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60004">
        <property type="protein sequence ID" value="QAS60004"/>
        <property type="gene ID" value="EI377_04035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000831">
        <property type="entry name" value="Trp_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038116">
        <property type="entry name" value="TrpR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013368">
        <property type="entry name" value="YecD_YerC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40080">
        <property type="entry name" value="PTHR40080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01371">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012508">
        <property type="entry name" value="YerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02531">
        <property type="entry name" value="yecD_yerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="98" mass="11115" checksum="B3E0C476A16948D8" modified="2018-12-05" version="1">MNGLESKLKNDELDLFFKAVLKLENIDECYKFFEDVATINELKALSQRINVANMLRKKMVYTEIAEDTGASTATISRVNKCLNYGTGGYNLALDRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE5</accession>
    <name>A0A386PHE5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF4091 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12745</name>
        <name evidence="7" type="ORF">EI377_07620</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02787"/>
    <dbReference type="EnsemblBacteria" id="AYE35220">
        <property type="protein sequence ID" value="AYE35220"/>
        <property type="gene ID" value="CP523_12745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60616">
        <property type="protein sequence ID" value="QAS60616"/>
        <property type="gene ID" value="EI377_07620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025150">
        <property type="entry name" value="GH123_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13320">
        <property type="entry name" value="DUF4091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BIG2" evidence="5">
        <location>
            <begin position="184"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="5">
        <location>
            <begin position="863"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1684"/>
            <end position="1703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1703" mass="191459" checksum="31A7E3443A9D8FC2" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF4</accession>
    <name>A0A386PHF4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS110 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33992">
        <property type="protein sequence ID" value="AYE33992"/>
        <property type="gene ID" value="CP523_05680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="409" mass="46968" checksum="7B092C73F0AC10AD" modified="2018-12-05" version="1">MHKKQNHVYVGLDLHKDTHTAVIIDCWDEKLDSITIENKPSDFTRLMNKVKKIAGKLIPVYGLEDVHGYGRSLAVFLIERGMIVKEVNSALSFMERMSYPTTKKSDDWDAKCIASVLLRKLDTLPNANPQDLYWTIKMMVNRRDSMVKTVTMLTNQLHENLNYNYPSYKKFFSDVNSKTALAFYEKYPSPKHLIGVTDEELAEFLRKPSHNSCSTRKAKEILDIVESDGDTTREYQESRDFIIQSIVRDIAFKNEEIKKVEVEMKKLLKLLDLKLETIPGVDTVTAIALVAHIGDIKRFRNADKLAKFSGIAPVNFSSAGKGKDKKSKQGNRELYGVFYFLAVQQIQVSKKGTPRNPIFLEYYKRKISEGKTKIQALVCVMRRLNNIIYGMMKNKTEYVMPNVEIKEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHF9</accession>
    <name>A0A386PHF9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14500</name>
        <name evidence="6" type="ORF">EI377_09475</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02493"/>
    <dbReference type="EnsemblBacteria" id="AYE35545">
        <property type="protein sequence ID" value="AYE35545"/>
        <property type="gene ID" value="CP523_14500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60931">
        <property type="protein sequence ID" value="QAS60931"/>
        <property type="gene ID" value="EI377_09475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362721" evidence="3">
        <location>
            <begin position="25"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="79"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="547" mass="60992" checksum="FE699CCDCE92A760" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG2</accession>
    <name>A0A386PHG2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage 0 sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08765</name>
        <name evidence="3" type="ORF">EI377_03515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678076.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02694"/>
    <dbReference type="EnsemblBacteria" id="AYE34501">
        <property type="protein sequence ID" value="AYE34501"/>
        <property type="gene ID" value="CP523_08765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59903">
        <property type="protein sequence ID" value="QAS59903"/>
        <property type="gene ID" value="EI377_03515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="301" mass="34297" checksum="A2819F48EFDBBAD1" modified="2018-12-05" version="1">MIKVVGVRFKKAGKIYYFDPKDLDIKKENYVVVETARGIEFGECVIGVKEIPEEDIVAPLKSVIRVAEQDDIDKHKNNKLKEKEALNICLKKIEEHGLNMKLIDVEYTFDNNKVIFYFTADGRVDFRELVKDLATIFKTRIELRQIGVRDEAKMLGGLGPCGRTMCCSSFLGDFASVSIKMAKEQNLSLNPTKISGICGRLMCCLNYEQSTYEDIRKRLPKVGSIVKIPDGQGEVISNNIVKESVKVKYKRVDEEVIEEFKIENVEIIEGSYEDSIDESDIKLEIELPEDKNLIKNLIKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHI6</accession>
    <name>A0A386PHI6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675024.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01882"/>
    <dbReference type="EnsemblBacteria" id="AYE34032">
        <property type="protein sequence ID" value="AYE34032"/>
        <property type="gene ID" value="CP523_05895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="285"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="377" mass="43030" checksum="7172471B7527528F" modified="2018-12-05" version="1">MINTLVKLIKKYKRNPVKTMLFFTSIFVAIITVSVGISSIEQLKILAYEKNDGVPDNTRVVDINLNKTVDHEQIKAIFKEVPEYCNVNIIKRFTYIDKASKYIGYPLIIHVRGDNTTNPIPILKGSYFKNNKKGNKDILIGYELEEFTEGDNENKKIRIYGEEYNVIGTLGYKNRATNWENRIILDLEDITKNNLDELKNGSFMVQIESDKGDIVKVCENFKKDLESSGENVLVNISEIGNKDQVYSTLLSHSKSFFKMIIIVYLISIINLIFISTGWVNTIHNEIGIMKVCGMSNFFIIRRIFMEFFVISLSATIGAIIFQYILSSIISRIDLLYFYISPNNILLGIGVAAITTTITLIVPIIQLIKMTPVKFLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN4</accession>
    <name>A0A386PHN4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-alanyl-CoA:ammonia lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14780</name>
        <name evidence="2" type="ORF">EI377_09740</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676121.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01328"/>
    <dbReference type="EnsemblBacteria" id="AYE35593">
        <property type="protein sequence ID" value="AYE35593"/>
        <property type="gene ID" value="CP523_14780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60979">
        <property type="protein sequence ID" value="QAS60979"/>
        <property type="gene ID" value="EI377_09740"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="149" mass="16591" checksum="C72F1AE9B47818F0" modified="2018-12-05" version="1">MRKEAVLSYKMTTADANNPGGIVPIGRQFDMWGDAETELMILNDGDESLCLGYSNVKFYEDIYCGDQIDFKATLVKVGNTSRKCKLQTFKVATSAKNAGVINAKSTDIIYYDTPKLVGEADVVLVVKKEVQRGIQPDGIVKNPWREIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI09</accession>
    <name>A0A386PI09_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NrdH-redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08800</name>
        <name evidence="3" type="ORF">EI377_03560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02701"/>
    <dbReference type="EnsemblBacteria" id="AYE34508">
        <property type="protein sequence ID" value="AYE34508"/>
        <property type="gene ID" value="CP523_08800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59911">
        <property type="protein sequence ID" value="QAS59911"/>
        <property type="gene ID" value="EI377_03560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="75" mass="8670" checksum="6C084CCC9F2814CE" modified="2018-12-05" version="1">MIKIYSTSWCPGCIKAKRFFDMKGWKYEEINVADRHEDREEVFKVSGQRTVPVVDVNGEIIVGFDKKAIEAAFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI58</accession>
    <name>A0A386PI58_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF871 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04855</name>
        <name evidence="4" type="ORF">EI377_15370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675764.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01704"/>
    <dbReference type="EnsemblBacteria" id="AYE33849">
        <property type="protein sequence ID" value="AYE33849"/>
        <property type="gene ID" value="CP523_04855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61995">
        <property type="protein sequence ID" value="QAS61995"/>
        <property type="gene ID" value="EI377_15370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008589">
        <property type="entry name" value="MupG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043894">
        <property type="entry name" value="MupG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043797">
        <property type="entry name" value="MupG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38435">
        <property type="entry name" value="PTHR38435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05913">
        <property type="entry name" value="DUF871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19200">
        <property type="entry name" value="DUF871_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF871_N" evidence="2">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DUF871" evidence="1">
        <location>
            <begin position="242"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="356" mass="40633" checksum="41E18BCA91A25E45" modified="2018-12-05" version="1">MAKGISIYFGLDYTLEKNLEYLDIANNYGFKEVFTSLHIPEMDYSEVVREFCLVVDKASALGMDITADISPKVFKFIGIEDDYEYFKRLGVKSIRLDFGYDINKIAKLSNNSYGLEIDLNASTITLDDLKKLKELGANFNNIKCTHNYYPKKYTGLGEDYFINQNKILKSYGLKVAAFVPSNNQRRGPIYDGLPTLECHRLGSAEMSWNHLIALGVDDIYFSDAYCSIDEIKSVAKLSDECVTLRVKTDKNITEKEKAILFGNIHCNRVDYSDVVIRSATVRGQDVKARKNDSYSYSGGMVTIDNELYKRYCGEVQIFIRDVKVDERSNVVCEVIKEDLYLLKHIKGNTKFIFVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI78</accession>
    <name>A0A386PI78_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02550</name>
        <name evidence="2" type="ORF">EI377_13085</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00457"/>
    <dbReference type="EnsemblBacteria" id="AYE35803">
        <property type="protein sequence ID" value="AYE35803"/>
        <property type="gene ID" value="CP523_02550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62220">
        <property type="protein sequence ID" value="QAS62220"/>
        <property type="gene ID" value="EI377_13085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02550"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="118" mass="13790" checksum="9FB1DD0ECC21D38A" modified="2018-12-05" version="1">MCVRLILSLVIVLGVMYLTFKVSGDRINRINRKNYIKVLERSQVSKDNFIVILKVGSKGYVMSSSNGKMEKLQDLSEEEILSIENKKLEEQNQLNEGYENIINKFKLIFNKYNKKNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI82</accession>
    <name>A0A386PI82_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ORF">CP523_09110</name>
        <name evidence="11" type="ORF">EI377_03855</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876963.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00260"/>
    <dbReference type="EnsemblBacteria" id="AYE34568">
        <property type="protein sequence ID" value="AYE34568"/>
        <property type="gene ID" value="CP523_09110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59968">
        <property type="protein sequence ID" value="QAS59968"/>
        <property type="gene ID" value="EI377_03855"/>
    </dbReference>
    <dbReference type="GeneID" id="66570367"/>
    <dbReference type="KEGG" id="csep:CP523_09110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="131" mass="13986" checksum="A8F7802D0A0EE6AB" modified="2018-12-05" version="1">MAAQKVKKTRRRKERKNVEHGAAHIKSTFNNSIVTLTDAAGNALSWSSAGALGFRGSRKSTPFAAQMAAETAAKAAMEHGLKSIEVYVKGPGAGREAAIRSLQAAGLEVTLIKDVTPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI96</accession>
    <name>A0A386PI96_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10525</name>
        <name evidence="4" type="ORF">EI377_05310</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674193.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01395"/>
    <dbReference type="EnsemblBacteria" id="AYE34801">
        <property type="protein sequence ID" value="AYE34801"/>
        <property type="gene ID" value="CP523_10525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60196">
        <property type="protein sequence ID" value="QAS60196"/>
        <property type="gene ID" value="EI377_05310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="136" mass="15584" checksum="0D8B24F0059941BF" modified="2018-12-05" version="1">MNIAFFLTPKNEVIYEYLDATMRQVIERMEHHGYTAIPLIDKGGKYVGTLTEGDLLWKLKNTPELNFKNTGSVKVTDIPRKRKHRSVSINSDVESLISLATTQNFVPVVDDEGTFIGIIKRSDIINYCYNEMKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA0</accession>
    <name>A0A386PIA0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34336">
        <property type="protein sequence ID" value="AYE34336"/>
        <property type="gene ID" value="CP523_07750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="93" mass="10797" checksum="82B74680F7E248D4" modified="2018-12-05" version="1">MYIKNINVNYGNKIIYKDFSINIESDKINCIIGQSGCGKTTLLKNISKELIKNGVEVSFVFQEDRLIPWKTVYENLYLISKSYYSKDKARGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIG2</accession>
    <name>A0A386PIG2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08135</name>
        <name evidence="3" type="ORF">EI377_02890</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675975.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00741"/>
    <dbReference type="EnsemblBacteria" id="AYE34396">
        <property type="protein sequence ID" value="AYE34396"/>
        <property type="gene ID" value="CP523_08135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59801">
        <property type="protein sequence ID" value="QAS59801"/>
        <property type="gene ID" value="EI377_02890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038728">
        <property type="entry name" value="YkvI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37814">
        <property type="entry name" value="PTHR37814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="354" mass="39299" checksum="3BF825DE5BF46E76" modified="2018-12-05" version="1">MRKELTKIFQIAVVFIGTIVGAGLASGQEITEFFTSYGVASFIGIIVCGIFYIAMGTIVSKISIKFRLNSYSDVIRVISPNILGKATGVITTLYLISSASIILAGSGALIHQFFGLPKIIGSLIMIVIAIFFLLRDTDGLIEVNSFIVPTLITTITLITVLYFLFCRDMLSLDFIAQFEPKKTGITKSTILYAGYNVLCCLGVLVPISNQTRKPKTMFYGIALGAIGLAFLSFAINLLLMINQPYIFEYEIPLLFVAQRFGSIIQALLLVVIWLEMFSTEVSDVYSISKTLEQVFKLNFKKGIFLVIAIALPISQIGFSKLIGKLYPFFGMLSLIFIVQTIYFYFKHKKELTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII8</accession>
    <name>A0A386PII8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase TatD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">TatD family deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08295</name>
        <name evidence="2" type="ORF">EI377_03040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01600"/>
    <dbReference type="EnsemblBacteria" id="AYE34426">
        <property type="protein sequence ID" value="AYE34426"/>
        <property type="gene ID" value="CP523_08295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59829">
        <property type="protein sequence ID" value="QAS59829"/>
        <property type="gene ID" value="EI377_03040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08295"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="261" mass="29986" checksum="46F9F282FD99114B" modified="2018-12-05" version="1">MENKYLIFDTHAHYDDEAFDEDRDLVLREINKNGVIGVMNCSSSYESIEKTDNLTKKYDFIYGALGIHPENANEFNSKVKSEIINYIEQNNKILAIGEIGLDYYWDENPSKEVQKEVFRAQMQMAKELKLPVVIHDREAHGDTLEIIKEFPEVNGIVHCFSGSVEFAKECVKLGYYIGITGVVTFKNAKKIVDVVKEIPVDKLLVETDCPYMAPVPNRGKRNKSDYIGYIIEQIGDIKEINPKKVNLKLNQNFRDLLKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIK7</accession>
    <name>A0A386PIK7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08445</name>
        <name evidence="6" type="ORF">EI377_03190</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674813.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01630"/>
    <dbReference type="EnsemblBacteria" id="AYE34456">
        <property type="protein sequence ID" value="AYE34456"/>
        <property type="gene ID" value="CP523_08445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59859">
        <property type="protein sequence ID" value="QAS59859"/>
        <property type="gene ID" value="EI377_03190"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="217" mass="24512" checksum="83031459475634E6" modified="2018-12-05" version="1">MNDNVIEIVNYTKIFKGTTVLKNINLNIIRGKCYGIVGRNGSGKTLIFKSICGFIRPTSGYVMVNGLKIGFDVDFPDDVGALIEQPGFLPNYNAFDNLKFLANIRNKIGNKEIEKVLKFVELYPIDNKLVKEYSLGMKQRLGIAQAIMEDPEILILDEPFNGLDKEGVKNLKEKLIELKEKGKTILMTSHIYQDIEELSDYIYEVDNGVLIKLKGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL6</accession>
    <name>A0A386PIL6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_08505</name>
        <name evidence="12" type="ORF">EI377_03255</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674852.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01642"/>
    <dbReference type="EnsemblBacteria" id="AYE34466">
        <property type="protein sequence ID" value="AYE34466"/>
        <property type="gene ID" value="CP523_08505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59869">
        <property type="protein sequence ID" value="QAS59869"/>
        <property type="gene ID" value="EI377_03255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="228" mass="26420" checksum="7383E01AEA566A92" modified="2018-12-05" version="1">MESRLGKVLIIDDDENICEVINMYLSSTGYETRMCHNGKDACTIFNSFKPELVLLDIMLPGMDGIEVLKWIRKHCEIPVIMLTAKGDTFDKVLALELGADDYIVKPFEPKELMARVKAVMRRYTYESVDKEVLSFSDLVIDVNSYNVLYKGEEIKMPPKEFELLYYLASNKNKVFTREQLLCEVWGYDYPGDSRTVDVHIKRLREKISGGENWQLETVWGVGYKFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR7</accession>
    <name>A0A386PIR7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13160</name>
        <name evidence="2" type="ORF">EI377_08005</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35297">
        <property type="protein sequence ID" value="AYE35297"/>
        <property type="gene ID" value="CP523_13160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60686">
        <property type="protein sequence ID" value="QAS60686"/>
        <property type="gene ID" value="EI377_08005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014871">
        <property type="entry name" value="dUTPase/dCTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016947">
        <property type="entry name" value="UCP030140"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08761">
        <property type="entry name" value="dUTPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030140">
        <property type="entry name" value="UCP030140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="176" mass="21075" checksum="DC6E5724B9362851" modified="2018-12-05" version="1">MPRLWKYGFRDNYNNTLINIKGLVMNIRNLLEMQKELDIAIFKKSDIDVYPTRKIELALRVELGELAQEFKEFKYWKKTKGEVNREKMLEEWADVFHFALSLENEEGNSFIDRAEEIAHRLNSDYTVYHLFQMCFKDPTVPRIIALGLNLGFTFKEMEQAYRYKNKINWDRVNGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS7</accession>
    <name>A0A386PIS7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673380.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02893"/>
    <dbReference type="EnsemblBacteria" id="AYE35021">
        <property type="protein sequence ID" value="AYE35021"/>
        <property type="gene ID" value="CP523_11670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="384" mass="42133" checksum="5D26A0410593FB75" modified="2018-12-05" version="1">MAKQFIMPKRIITGKGALEEGKKYLNNFGKKVLIITDKVMVQLGNVKVITDILEEEKIEYVIYSEINSEPTDTMIDNGIKLYQMENCNFLIALGGGSPIDSAKAIAAMITNEGSIADYKGREISNELPPVVAIPTTAGTGSEATQFTIITDTKNDVKMLLKGAALLPVLAIIDPRFTVTSPAKVTAATGLDALTHAIEAYTSRKSQQLSDVFAISAVKRIFKYLPIAFENPKDLKAREEMALAALEAGIAFNNSSVTIVHGMSRPIGALFHIAHGLSNAILLKECFEYVVDGAYDKFAQLAREINVVNNEIEDEVAAEIFIKEIGKLIDILRIPNINELGIDKIKFLNNIEKMAKDAIESGSPSNTRKIIEAKDIINIYNNLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIU2</accession>
    <name>A0A386PIU2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15685</name>
        <name evidence="2" type="ORF">EI377_10405</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678605.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35760">
        <property type="protein sequence ID" value="AYE35760"/>
        <property type="gene ID" value="CP523_15685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61099">
        <property type="protein sequence ID" value="QAS61099"/>
        <property type="gene ID" value="EI377_10405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="101" mass="11652" checksum="4275E08DDB21D18F" modified="2018-12-05" version="1">MFFNNNSEGLFTLILKRQAKVITIKIVIEITPTIKFLKIITSSVQINTFFVVFSKKYPIIDEKVCLIITKLPLASKWLLNTEIIIDRSEQNAKIDNILKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX6</accession>
    <name>A0A386PIX6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03400</name>
        <name evidence="2" type="ORF">EI377_13925</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679111.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00059"/>
    <dbReference type="EnsemblBacteria" id="AYE35810">
        <property type="protein sequence ID" value="AYE35810"/>
        <property type="gene ID" value="CP523_03400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62228">
        <property type="protein sequence ID" value="QAS62228"/>
        <property type="gene ID" value="EI377_13925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03400"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="25700" checksum="2C813163D5A22E76" modified="2018-12-05" version="1">MFEKLNSNNYNPHDFNNNVNYFIGGNPITSFNKESKFPNIHPTVFIGSFSSIIGDVTISENVFIACNAVIRADEGTPFFIGVNTNIQDGVILHGLEDGKVNVDSKEYSIYISDNVSCAHGALIHGPCLLHSKCFISFNSIVFNATIGKNTYVSPNAIVTGGVIVADNKFIPPSMIVDTQEIADMLPQLPKDKEDFSETVRKINKEFPASYTTMFGSARCSCGLCYNPSKIMNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ09</accession>
    <name>A0A386PJ09_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">uvrC</name>
        <name evidence="10" type="ORF">CP523_06410</name>
        <name evidence="11" type="ORF">EI377_00885</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677416.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02158"/>
    <dbReference type="EnsemblBacteria" id="AYE34129">
        <property type="protein sequence ID" value="AYE34129"/>
        <property type="gene ID" value="CP523_06410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59496">
        <property type="protein sequence ID" value="QAS59496"/>
        <property type="gene ID" value="EI377_00885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="255"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="619" mass="71772" checksum="259D8851654DD204" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
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    <name>A0A386PJ49_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675217.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01982"/>
    <dbReference type="EnsemblBacteria" id="AYE35201">
        <property type="protein sequence ID" value="AYE35201"/>
        <property type="gene ID" value="CP523_12645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="113" mass="12972" checksum="DF258042ED30D890" modified="2018-12-05" version="1">MSDKDKLGVLMGEKIDTHQYDYNGTTKTARDKAMNLYELLKKKELPVPYVIVAHSLGGHIAIEFAKMYGDELAGIVFVDASGRNQLGGNWGFFENYLPEMIEPFFLRYKNRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ66</accession>
    <name>A0A386PJ66_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12750</name>
        <name evidence="2" type="ORF">EI377_07625</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35221">
        <property type="protein sequence ID" value="AYE35221"/>
        <property type="gene ID" value="CP523_12750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62177">
        <property type="protein sequence ID" value="QAS62177"/>
        <property type="gene ID" value="EI377_07625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="27" mass="2702" checksum="69D3837F43235C1C" modified="2018-12-05" version="1">MASAATVLVLGTLASVTGAIMIKKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ87</accession>
    <name>A0A386PJ87_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">recR</name>
        <name evidence="9" type="ORF">CP523_07050</name>
        <name evidence="10" type="ORF">EI377_01795</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673688.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01026"/>
    <dbReference type="EnsemblBacteria" id="AYE34229">
        <property type="protein sequence ID" value="AYE34229"/>
        <property type="gene ID" value="CP523_07050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59634">
        <property type="protein sequence ID" value="QAS59634"/>
        <property type="gene ID" value="EI377_01795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07050"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="81"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="198" mass="21968" checksum="11D309895A513265" modified="2018-12-05" version="1">MDFYPVAIEKLIEEFAKLPSIGQKTAQRLTLHILNLPEDEVKEFATALVKARGTIKYCTVCGNFTDKDPCAICGNPNRDKNVICVVEQPKDIMTMEKVKEFNGIYHVLHGNLSPMQGRGPQDIRIRELVARMSADVKEVIIATNPNIEGEATAMYIARILKPLDIKVTRIASGIPVGGDLEYADEVTLSKALEGRKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG0</accession>
    <name>A0A386PJG0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sepF</name>
        <name evidence="6" type="ORF">CP523_14910</name>
        <name evidence="7" type="ORF">EI377_09865</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676074.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01301"/>
    <dbReference type="EnsemblBacteria" id="AYE35617">
        <property type="protein sequence ID" value="AYE35617"/>
        <property type="gene ID" value="CP523_14910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61004">
        <property type="protein sequence ID" value="QAS61004"/>
        <property type="gene ID" value="EI377_09865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="148" mass="16554" checksum="2E23CB3E985433B2" modified="2018-12-05" version="1">MGNMFGKFKDLIGMGDYEDEFDEFEDDDIEEEEEDIEPIISKQKGSKVVNIHSAATAKVMVTKPVGYDDAREIADAIKARKIVLVNATGLETKIAQRLVDFISGSCYVLGATLQEIEQRVYLLSPSNVEVTNELKNELSSKALFNWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN0</accession>
    <name>A0A386PJN0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12365</name>
        <name evidence="3" type="ORF">EI377_07250</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675357.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02040"/>
    <dbReference type="EnsemblBacteria" id="AYE35148">
        <property type="protein sequence ID" value="AYE35148"/>
        <property type="gene ID" value="CP523_12365"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60551">
        <property type="protein sequence ID" value="QAS60551"/>
        <property type="gene ID" value="EI377_07250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12365"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="248" mass="28505" checksum="A5276FBA1AC200F7" modified="2018-12-05" version="1">MKFASDNPKASKKLLYTLVYDKLYKMIINGEYPINSKLPSEPQLAKMFGVSRMTLRQALSLLQDDGLVKNIHGKGNFITSPEKCNKKDFLELIGNPIYKCHNEPITDVELYFRLDLESEHTKQVLERSSAAVVACERYYKSNNKIIAYAFTFISIETILEMNIDLNNKDEVLDFLENKSYEVSTSSMLEIKRSTAGNTAHPKYKLVGGEQCDLILETLYINDYSPPILFNKYYIPCQYSTFRIKATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJT1</accession>
    <name>A0A386PJT1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_14390</name>
        <name evidence="10" type="ORF">EI377_09355</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676803.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02469"/>
    <dbReference type="EnsemblBacteria" id="AYE35524">
        <property type="protein sequence ID" value="AYE35524"/>
        <property type="gene ID" value="CP523_14390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60910">
        <property type="protein sequence ID" value="QAS60910"/>
        <property type="gene ID" value="EI377_09355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="225" mass="25559" checksum="90B0834A0E5DA3BE" modified="2018-12-05" version="1">MQKNILIVEDELRIRFLLRDYFLKEGFHIIEASDGDEGINAFSNNKIDLVILDIMMPKVDGITVLEIIRKSSDVPVILLTAKGQEEDKLFGYEMGADDYITKPFSPKVLIAKVKALLKRTSEISDTNNKNFSGLTINRLSHEVKINGNLVNLSPKEFELITYLADNEGIALSRDNILDHVWGIDYYGDIRTVDTNVKRLREKLGDKANLIVTVRGSGYRFESKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU0</accession>
    <name>A0A386PJU0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15770</name>
        <name evidence="3" type="ORF">EI377_10480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678923.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35777">
        <property type="protein sequence ID" value="AYE35777"/>
        <property type="gene ID" value="CP523_15770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61114">
        <property type="protein sequence ID" value="QAS61114"/>
        <property type="gene ID" value="EI377_10480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="261" mass="29212" checksum="FD6620CB14A73ED0" modified="2018-12-05" version="1">MKRSVVDNKFKTNKVGLQMGYIIISFLISILTMQVLTLFKLMLILDIQMSDVLYIGEAILIIGTILTVIGGMDFLKDNLFREESILKGIGIGTISGLGIMFITYLYRIIPVFIGKRVIAIGSNQAVSTYKDFSFESLLVTSITPAILEEFVFRVGGFTICAVIFRFIFQQIRKDKKSLIEINVLNLRSRYGLMALIFTSLIFAIMHGPSILSLPIYLLPGLLFGFLYCKYGLGVSIVSHCMSNYLSSLILTLVVFLINLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJZ0</accession>
    <name>A0A386PJZ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplA</name>
        <name evidence="10" type="ORF">CP523_08915</name>
        <name evidence="11" type="ORF">EI377_03670</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678830.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01782"/>
    <dbReference type="EnsemblBacteria" id="AYE34529">
        <property type="protein sequence ID" value="AYE34529"/>
        <property type="gene ID" value="CP523_08915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59931">
        <property type="protein sequence ID" value="QAS59931"/>
        <property type="gene ID" value="EI377_03670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="24547" checksum="4FF5E5B0A412E16E" modified="2018-12-05" version="1">MGKNYIESAKLIDKNVLYTPSEALDLAVKTAKAKFDETIELHVRLGVDPRHADQQVRGAVVLPNGTGKTVRVLVFAKGEKAKEAQEAGADFVGAEDLVQKIQSENWFDYDVVVATPDMMGVVGRIGRVLGPKGLMPNPKSGTVTFDVAKAIAEIKAGKVEYRVDKTAIVHCPIGKKSFGVEKLQQNFQALMDALIKAKPAAAKGQYVKSVSVSSTMGPGAKVNPTKVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK07</accession>
    <name>A0A386PK07_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1290 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14895</name>
        <name evidence="4" type="ORF">EI377_09850</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676083.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01304"/>
    <dbReference type="EnsemblBacteria" id="AYE35614">
        <property type="protein sequence ID" value="AYE35614"/>
        <property type="gene ID" value="CP523_14895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61001">
        <property type="protein sequence ID" value="QAS61001"/>
        <property type="gene ID" value="EI377_09850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="117" mass="12499" checksum="8C2E97F8B62854E6" modified="2018-12-05" version="1">MIAFIGLLLGVLLGLLLDVNIPDTFSPYMSVAILACLDSVFGAVRASMSKTFKADIFISGFFGNAALAAGLAYLGDKLGIPVYIAAVIVFGSRIFDNFATIRRLAIEKAKAYKRGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK12</accession>
    <name>A0A386PK12_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Major capsid protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13220</name>
        <name evidence="2" type="ORF">EI377_08065</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679061.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01960"/>
    <dbReference type="EnsemblBacteria" id="AYE35308">
        <property type="protein sequence ID" value="AYE35308"/>
        <property type="gene ID" value="CP523_13220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60697">
        <property type="protein sequence ID" value="QAS60697"/>
        <property type="gene ID" value="EI377_08065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005564">
        <property type="entry name" value="Major_capsid_GpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03864">
        <property type="entry name" value="Phage_cap_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="341" mass="37750" checksum="C8EA38035F87BF3B" modified="2018-12-05" version="1">MPRLEEVFSTKELINYYKDRKVVPMLGDSLFPERKIQDIEFDMILGRGGIPVSASVHALDTQTELASREAINKGVASLALIKRQIKITEKEIIKINNPRTNAELESTLLELYKDADKMVEAIKVRVEAMRMELLSSGKIRIEENGVKVTMDYGFLPVNKKTFNWSDTETSKPLDDLETLAAAVEGSSGSRPVRALTSRKIVNKIRSNKSVREAVHGINSAKTVTLSQLNDLLEELDLPRFVVNEGKYKVEKAKGFDTKRYFPENVISMFGPEVLGETIYGLTAEEVKLIGDSKMEEALMIGNIFAGTYSSIDPVGEFTKAAATALPSCPTAEEIGIATITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK20</accession>
    <name>A0A386PK20_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="3" type="ORF">CP523_14945</name>
        <name evidence="4" type="ORF">EI377_09900</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01295"/>
    <dbReference type="EnsemblBacteria" id="AYE35624">
        <property type="protein sequence ID" value="AYE35624"/>
        <property type="gene ID" value="CP523_14945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61010">
        <property type="protein sequence ID" value="QAS61010"/>
        <property type="gene ID" value="EI377_09900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="458"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="583" mass="68513" checksum="0848DD82B3D65A3A" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK61</accession>
    <name>A0A386PK61_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GSDH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11965</name>
        <name evidence="4" type="ORF">EI377_06785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02950"/>
    <dbReference type="EnsemblBacteria" id="AYE35072">
        <property type="protein sequence ID" value="AYE35072"/>
        <property type="gene ID" value="CP523_11965"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60465">
        <property type="protein sequence ID" value="QAS60465"/>
        <property type="gene ID" value="EI377_06785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11965"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="GSDH" evidence="2">
        <location>
            <begin position="111"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="429" mass="48409" checksum="48253F89F43A94ED" modified="2018-12-05" version="1">MKHFIKFLIISILIVTCAFGIFKLTNKYDLDVIYKNIDWSITLKGCNGAKSFDFDKDGNLYIAFKDTIRIINKDGKDEVIINENSFDILDILWSEDKLFIATGNRVIQYDPKIHESKDLITEIPNKGENKNIQLLCDGKTLYLSVGSNTNSGIVSEKGQPEDLSTIQWILSGKNCGEVQTGPFSPYSVTVEKGEKTKEGVIGNASIIAYDLKKGETSIFSHGIRNIKGFDIDSTGKLKGIVGGMEDKGLRPIKNDKDYIYEFKKGAWYGWPDYSGGDPITSPRFTDNEKIDFLIENHPVKTPAAPLYQHKDINSLNGFAIDKEGRFFLKDTMIFADNKKGSLYARTDEGVLKELIDLGENSYVEKVKFYEDGFFILDSRLGCLYRLETINNGSLFNLPKVVWIFAIGFLIVLVMCLAFKFNNKKVVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK80</accession>
    <name>A0A386PK80_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glutaminase</fullName>
            <ecNumber evidence="3 5">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">glsA</name>
        <name evidence="6" type="ORF">CP523_13700</name>
        <name evidence="7" type="ORF">EI377_08590</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677169.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02082"/>
    <dbReference type="EnsemblBacteria" id="AYE35398">
        <property type="protein sequence ID" value="AYE35398"/>
        <property type="gene ID" value="CP523_13700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60787">
        <property type="protein sequence ID" value="QAS60787"/>
        <property type="gene ID" value="EI377_08590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="PTHR12544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="305" mass="33230" checksum="4BA06A69C902F8EB" modified="2018-12-05" version="1">MFNLLNTLVEKNRVYGAEGKLASYIPALLKANPNDLGVCVVDLHGNEYSAGECDTKFTIQSISKVVTLILALRDNGRKNVFKKVNVEPTGMGFNSIVNLEVTQSDRPYNPMINAGAIVTTSLIGGETEEEKLNKIIDFLKRATNNDDITVNEEVYISEKETGDRNRSLAYFMKSNGILTGNVEEILDLYFKQCSIEITARDLARFGAVLANEGVTPWGDERLMSREVCRIVKTIMVTCGMYDASGEFAVHVGIPAKSGVGGGTLATVPRRYGIGIFGPSLDSKGNSIAGLKVIKDLSDELDLSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKA0</accession>
    <name>A0A386PKA0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS fructose transporter subunit IIA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PTS sugar transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_09605</name>
        <name evidence="5" type="ORF">EI377_04380</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676690.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02627"/>
    <dbReference type="EnsemblBacteria" id="AYE34659">
        <property type="protein sequence ID" value="AYE34659"/>
        <property type="gene ID" value="CP523_09605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60059">
        <property type="protein sequence ID" value="QAS60059"/>
        <property type="gene ID" value="EI377_04380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="143" mass="15259" checksum="72FE8F6348185566" modified="2018-12-05" version="1">MVGVIVTGHGNFATGLLSSLKLIAGEQEHIVGVDFTADDSTETLEVKLKDAVDKLGEEIIVLSDLAGGSPFKVSVVLSQQLEGKKIKVVSGINLGMLLEVSLCRGSMSLDELVGFSIDSGKDAIKSFEIRVEEEIETYEFDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKD4</accession>
    <name>A0A386PKD4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15580</name>
        <name evidence="3" type="ORF">EI377_10295</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678689.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35741">
        <property type="protein sequence ID" value="AYE35741"/>
        <property type="gene ID" value="CP523_15580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61080">
        <property type="protein sequence ID" value="QAS61080"/>
        <property type="gene ID" value="EI377_10295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="109" mass="12701" checksum="A4E6A38D80DECC1C" modified="2018-12-05" version="1">MFNDNRGYCEHCKKIQPYILKGKKVTKDLNIGRIEVVEASAYCLVCNELIYSEKVREKNKKEVEIAIEKLQEEIEILHMLRSSKTSKLISDASDEKILEEIKSILRDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI7</accession>
    <name>A0A386PKI7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_10395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01421"/>
    <dbReference type="EnsemblBacteria" id="AYE34779">
        <property type="protein sequence ID" value="AYE34779"/>
        <property type="gene ID" value="CP523_10395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037778">
        <property type="entry name" value="UCP037778_transp_RibU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="198" mass="21614" checksum="5520CB32576749DC" modified="2018-12-05" version="1">MNNENKNLNKLVKISLLGAIAVILMYFDFPVIPAFDWLKIDLSDVPALMGGFAFGPLAGIVIELIKNLLILIVKGTNTGFVGEFANFIVGVSLVAPAAWFYHRNKNKKTALIGMGLGFIAIEIVGIIANVYLLLPAYGMHMESAALLQYITVGLLPFNGIKAVIVSVVTYVLYKKVSMAIFKVDSNFNSEKKEQLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKR3</accession>
    <name>A0A386PKR3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CP523_12940</name>
        <name evidence="19" type="ORF">EI377_07820</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678215.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03024"/>
    <dbReference type="EnsemblBacteria" id="AYE35256">
        <property type="protein sequence ID" value="AYE35256"/>
        <property type="gene ID" value="CP523_12940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60651">
        <property type="protein sequence ID" value="QAS60651"/>
        <property type="gene ID" value="EI377_07820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12940"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AYE35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QAS60651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="183" mass="21078" checksum="AB62424496D63D47" modified="2018-12-05" version="1">MICLVVGGAKSGKSMYGQNLAKALEDKNGNLYYVATMNPYDLEDLKRIENHLKDREGYGFKTIEKQKNIEEVLGYINENDTLLIDSITSLVTNEMFLEKDFIKDVKSKIIMGLEQIKERSKNVIIVSDYVFGDSIIYDNYTENFRRELGNINREIAFFSDIVIECIYGNVIKHKGKELLKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL33</accession>
    <name>A0A386PL33_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11840</name>
        <name evidence="6" type="ORF">EI377_06660</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02926"/>
    <dbReference type="EnsemblBacteria" id="AYE35049">
        <property type="protein sequence ID" value="AYE35049"/>
        <property type="gene ID" value="CP523_11840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60442">
        <property type="protein sequence ID" value="QAS60442"/>
        <property type="gene ID" value="EI377_06660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788001" description="Peptidase_M23 domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="4">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="458" mass="51261" checksum="BDD6CBE114E9A2EB" modified="2018-12-05" version="1">MKSKKVKSIIFMLTCVLTLNYSVIWAESTGDIQEQIDKNKESMNQLESEKDKLNKEKEQEKSKLDEILNDIDSKSNDLNKVTEEVNNYQNKIDSIQSEIDNIHNNILSTQNDISNKETLIKLKEEEQKSTQELLDKRLRSYYKVDMTSQYIYMVLKSKSITELFNTMGNVLRIMLIDRELINKAKESQYILNNEKKELNEKVEQMNREEEAIVVKQNELKDAQKEFLVKQEEQQKQINNLMALESEKSSYIDSLSDKEKELAGKIGDLISYNKDLQKELDDIFANINNNNNSNNSGNSNSNNVNSGNSESSGNSNSNNVNSGNSESSGNSSEESFLRPGVGVITDEYGPRINPVTGESGFHTGVDLGDAYGAPVKAAKSGTVDYSGWISGYGNTIIINHGNGVQTLYAHNSELLVDVGQTVSRGQTIAKVGSTGMSTGPHIHWEIRINGQHVSPMGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLE1</accession>
    <name>A0A386PLE1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ECF transporter S component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14685</name>
        <name evidence="3" type="ORF">EI377_09650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678852.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00137"/>
    <dbReference type="EnsemblBacteria" id="AYE35576">
        <property type="protein sequence ID" value="AYE35576"/>
        <property type="gene ID" value="CP523_14685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60962">
        <property type="protein sequence ID" value="QAS60962"/>
        <property type="gene ID" value="EI377_09650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="188" mass="20042" checksum="E43C925272E2BFAC" modified="2018-12-05" version="1">MKKNNTFKIIMMSLCVVFNILGSFLAVALKLPIYIDTIGTFLSSFLFGPIGGMLTGGATAIIAGISFDPMSLYFIPVQLVIGYFAGVFYKKNLFAGKFIPVGVILVTVISSIVASVIAAFVFGGITSSGSSIIVMYLKEAGVNLVTSVFSTQILTDILDKSVAVILVLGILKTIPVSIKEKYSIFKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLN9</accession>
    <name>A0A386PLN9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35716">
        <property type="protein sequence ID" value="AYE35716"/>
        <property type="gene ID" value="CP523_15455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="57" mass="6991" checksum="34EAF4613B502F59" modified="2018-12-05" version="1">MEVNKQTEANKRWQEKNKEHSNYLKDRSKARSFIRNKATEEDLKELDELISERRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLP0</accession>
    <name>A0A386PLP0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase I</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">polA</name>
        <name evidence="10" type="ORF">CP523_13705</name>
        <name evidence="11" type="ORF">EI377_08595</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677167.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02081"/>
    <dbReference type="EnsemblBacteria" id="AYE35399">
        <property type="protein sequence ID" value="AYE35399"/>
        <property type="gene ID" value="CP523_13705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60788">
        <property type="protein sequence ID" value="QAS60788"/>
        <property type="gene ID" value="EI377_08595"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="8">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="9">
        <location>
            <begin position="625"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00482"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="QAS60788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
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            <dbReference type="Proteomes" id="UP000280586"/>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="868" mass="98750" checksum="6C177B331BC28EA2" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
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                <person name="Leendertz F.H."/>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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    <dbReference type="EnsemblBacteria" id="AYE35469">
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            <end position="33"/>
        </location>
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            <begin position="34"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
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            <begin position="383"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="SMART" id="SM00635"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1252" mass="140817" checksum="077439BEC8072343" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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                <person name="Seyboldt C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 7534</strain>
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    </reference>
    <reference evidence="5" key="2">
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            <authorList>
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                <person name="Leendertz F.H."/>
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        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 8">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00375"/>
    <dbReference type="EnsemblBacteria" id="AYE35816">
        <property type="protein sequence ID" value="AYE35816"/>
        <property type="gene ID" value="CP523_04515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62236">
        <property type="protein sequence ID" value="QAS62236"/>
        <property type="gene ID" value="EI377_15060"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="45"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="QAS62236.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RemA-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="77" mass="8569" checksum="9158CCBFEFA3601D" modified="2018-12-05" version="1">MNKLINVGYENTVNMEKVISITNAKSSPTRRMIQRAKEKDLLVDATEGKKTVTAIVMESGHVILSAVRIETLKKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAT0</accession>
    <name>A0A386PAT0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA pyrophosphatase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">EI377_10940</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00618"/>
    <dbReference type="EnsemblBacteria" id="AYE33025">
        <property type="protein sequence ID" value="AYE33025"/>
        <property type="gene ID" value="CP523_00450"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61194"/>
        <property type="gene ID" value="EI377_10940"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="208" mass="24614" checksum="D319395592FE3EEA" modified="2018-12-05" version="1">MINKLKIIFNKFDPYINGWEYMKRASVAIIILEENGEENVIFQVRSKKMKSQPGDISFTGGKIDKDETPKEAIVREIWEEIGLDINDFDIITELDTLVTHYGLIIHPFIVYIKNMNNIKINKSEVDHIFSVPLKFLYENKPTIINNEILIKRNEKFPFELINNGENYKFKNGIYPSLFYIYNEYVIWGITAKILENFIKELNKKNYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAU8</accession>
    <name>A0A386PAU8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DeoR/GlpR transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_00555</name>
        <name evidence="6" type="ORF">EI377_11045</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676335.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00641"/>
    <dbReference type="EnsemblBacteria" id="AYE33045">
        <property type="protein sequence ID" value="AYE33045"/>
        <property type="gene ID" value="CP523_00555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61214">
        <property type="protein sequence ID" value="QAS61214"/>
        <property type="gene ID" value="EI377_11045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="27434" checksum="F263E7570ADD3DAE" modified="2018-12-05" version="1">MVSEKRHSIILNLVNSKGVITLSEIMNETNSSESTIRRDLTFLEEKGALKRIHGGAKTISSPSEELTYSEKSSKNLQAKSDIAKLASLEVNNGDSIFLDAGTTTIEIIKYLKDKNIFVVTNGLKHIDELIDNNINCYLLGGKIKFTTKAIIGGDALKCINKFRFDKCFLGSNGIHVSMGCTTPDTEEAIIKEAAIKNSKKSYILCDDSKFGEVSLVKFGDIQDVTIITNNIENISTYKNLTEVKVVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB73</accession>
    <name>A0A386PB73_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate C-acetyltransferase/glycerol dehydratase family glycyl radical enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Glycyl radical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_00250</name>
        <name evidence="10" type="ORF">EI377_10635</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01182"/>
    <dbReference type="EnsemblBacteria" id="AYE32990">
        <property type="protein sequence ID" value="AYE32990"/>
        <property type="gene ID" value="CP523_00250"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61142">
        <property type="protein sequence ID" value="QAS61142"/>
        <property type="gene ID" value="EI377_10635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010098">
        <property type="entry name" value="PFL2/GDeHydtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01774">
        <property type="entry name" value="PFL2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0556">Organic radical</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="8">
        <location>
            <begin position="10"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="667"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="5">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="802" mass="90655" checksum="439EE7163142D5E0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBE5</accession>
    <name>A0A386PBE5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">nusA</name>
        <name evidence="9" type="ORF">CP523_00685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676383.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00668"/>
    <dbReference type="EnsemblBacteria" id="AYE33070">
        <property type="protein sequence ID" value="AYE33070"/>
        <property type="gene ID" value="CP523_00685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="367" mass="40547" checksum="DAD538E94CD23341" modified="2018-12-05" version="1">MNQEFIGALKEIVKDKGISEDLIFTTIEDALVAAYKKNYASPTTAAQNVKVTIDRETGEIHVYAQKVVVEDVYDGVTEISIEEAKEISPRYDLDDIVDLEVTPKNFGRVAAQLAKGVVTQRIREAERTIVYSEYKEKEYDIITGTILRKDKGNVFVNLGRIEGAIGPNEQMPGEEYKFNEKLKLYVVEVKNGSKGAQVLVSRTHPGLVKRLFELEVPEIFEGIVEIKSISREAGSRSKIAVYSNDENVDPMGACVGPKGSRVQNIVNELKGEKIDIIKWSKDPEEFIASSLSPAKVLEVKVDESNKSAKVVVDDNQLSLAIGKEGQNVRLAAKLSGWKIDIKSKSQAEAAKLEAAEEVVETTETLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBH3</accession>
    <name>A0A386PBH3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 5" type="primary">acpP</name>
        <name evidence="5" type="ORF">CP523_00840</name>
        <name evidence="6" type="ORF">EI377_11335</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674587.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02351"/>
    <dbReference type="EnsemblBacteria" id="AYE33100">
        <property type="protein sequence ID" value="AYE33100"/>
        <property type="gene ID" value="CP523_00840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61270">
        <property type="protein sequence ID" value="QAS61270"/>
        <property type="gene ID" value="EI377_11335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00840"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="8759" checksum="2AA68F692749FC8B" modified="2018-12-05" version="1">MFEKIREIIAEKLSISEDDITMEASFVEDLNADSLDLVELMMALEDELDMEIPDEEAENFKTVGDVVKYLKENVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBK2</accession>
    <name>A0A386PBK2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01970</name>
        <name evidence="4" type="ORF">EI377_12490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678258.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01154"/>
    <dbReference type="EnsemblBacteria" id="AYE33313">
        <property type="protein sequence ID" value="AYE33313"/>
        <property type="gene ID" value="CP523_01970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61483">
        <property type="protein sequence ID" value="QAS61483"/>
        <property type="gene ID" value="EI377_12490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="73" mass="8113" checksum="427E986410FE5629" modified="2018-12-05" version="1">MCICDLKLGEKGKIESIKGDDRLAKRLFALGCIEGTEIELKRIAPLGDPIIVNLRGFDLAIRKKDAKNIFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBU8</accession>
    <name>A0A386PBU8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01515</name>
        <name evidence="4" type="ORF">EI377_12035</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675645.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33230">
        <property type="protein sequence ID" value="AYE33230"/>
        <property type="gene ID" value="CP523_01515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61402">
        <property type="protein sequence ID" value="QAS61402"/>
        <property type="gene ID" value="EI377_12035"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="8088" checksum="6FECC8EB6E01390C" modified="2018-12-05" version="1">MLPINLVKEGEIVEIQKLALKEDFAKRMMEIGLVAGNKITVVKNDGRCIIISIGESRFALDMTLARKIMIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBV6</accession>
    <name>A0A386PBV6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01565</name>
        <name evidence="2" type="ORF">EI377_12085</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675665.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33240">
        <property type="protein sequence ID" value="AYE33240"/>
        <property type="gene ID" value="CP523_01565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61412">
        <property type="protein sequence ID" value="QAS61412"/>
        <property type="gene ID" value="EI377_12085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="191" mass="22160" checksum="64A547363060A0AF" modified="2018-12-05" version="1">MSTKLIQTKVVIAQGTENIFQQYLIDLTEKVGNQTPDEIFMIESVKSWFELKDAHVTREGSVVIFDGYIHKNIMYKVKKEKGEKGEDETVIGEMKHITIKRPFNGLVEVTPIDKSVCFDPDTDFVELVEAKILGEVDDPIARKHEDDEKTTKINEKMAIRMTFKVVRWEHLKVETDEHHHPHPEPHSFCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC84</accession>
    <name>A0A386PC84_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein CP523_00770</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00770</name>
        <name evidence="4" type="ORF">EI377_11265</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674623.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02366"/>
    <dbReference type="EnsemblBacteria" id="AYE33087">
        <property type="protein sequence ID" value="AYE33087"/>
        <property type="gene ID" value="CP523_00770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61256">
        <property type="protein sequence ID" value="QAS61256"/>
        <property type="gene ID" value="EI377_11265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="123" mass="14800" checksum="E5F1ABF6970FD341" modified="2018-12-05" version="1">MKSFNKDIGNYGEDLAYNYLIHKGYYILKRNFRNRFGEIDLICKKDGIIIFVEVKSRYSSSYGTPLEAITYYKQKQIINLCKFYITLNKLYNYNCRFDVIEILLNQKNNLFLLNHYEDAFRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCM2</accession>
    <name>A0A386PCM2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Serine acetyltransferase</fullName>
            <ecNumber evidence="4 9">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cysE</name>
        <name evidence="10" type="ORF">CP523_04070</name>
        <name evidence="11" type="ORF">EI377_14590</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02772"/>
    <dbReference type="EnsemblBacteria" id="AYE33705">
        <property type="protein sequence ID" value="AYE33705"/>
        <property type="gene ID" value="CP523_04070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61860">
        <property type="protein sequence ID" value="QAS61860"/>
        <property type="gene ID" value="EI377_14590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04070"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="194" mass="21064" checksum="4179F97485E18C51" modified="2018-12-05" version="1">MFSRLKYDLENILENDPAARSKLEVFLLYPCIHALIAYRISNYFYKNKWFFLARLISQISRFLTGIEIHPGATIGKGLFIDHGMGVVIGETAEIGDDVTLYHGVTLGGTGKDKGKRHPTVGNRVIIGAGAKVLGPITLGDDCKVGANTVVLKDVPKGATAVGCAGKNLIRNVCDIIDLVDEDGNTKTIYNDMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCT8</accession>
    <name>A0A386PCT8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04500</name>
        <name evidence="2" type="ORF">EI377_15040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00378"/>
    <dbReference type="EnsemblBacteria" id="AYE33785">
        <property type="protein sequence ID" value="AYE33785"/>
        <property type="gene ID" value="CP523_04500"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61942">
        <property type="protein sequence ID" value="QAS61942"/>
        <property type="gene ID" value="EI377_15040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04500"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018891">
        <property type="entry name" value="Abortive_phage_infection"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10592">
        <property type="entry name" value="AIPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="614" mass="71660" checksum="06377E2A4B6015C7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCV6</accession>
    <name>A0A386PCV6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04620</name>
        <name evidence="4" type="ORF">EI377_15175</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675823.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33805">
        <property type="protein sequence ID" value="AYE33805"/>
        <property type="gene ID" value="CP523_04620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61962">
        <property type="protein sequence ID" value="QAS61962"/>
        <property type="gene ID" value="EI377_15175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="152" mass="17350" checksum="70C51B22CF76BD63" modified="2018-12-05" version="1">MNLGENIKKLRKEKGLSQEQLAEMLNVSRQAVSKWESGKTYPDIDNLILLKGIFNVTLDDLIINDDKTKSEDTIESSKSCDNNEIEYDRDEEVEEVEEDDELSVNLILACFIIGTAIGFITDNFMWGTAGSFIGMGIGYILEYIRKRELYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD30</accession>
    <name>A0A386PD30_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01535</name>
        <name evidence="3" type="ORF">EI377_12055</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675654.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00859"/>
    <dbReference type="EnsemblBacteria" id="AYE33234">
        <property type="protein sequence ID" value="AYE33234"/>
        <property type="gene ID" value="CP523_01535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61406">
        <property type="protein sequence ID" value="QAS61406"/>
        <property type="gene ID" value="EI377_12055"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="257" mass="30387" checksum="6EC71929135F6249" modified="2018-12-05" version="1">MRVMTFNLRTDFILDINNRWKHRSDIVYEVIKRYNCDIIGVQELTEKMLNDIKENINNYNIVGKARSQKLFIERNDILVSKKHKIIEHDTFWLSNNPNKQGSSVWYSMYPRICTTAVIELENNKIIRVYNTHLDCLLPKAREYGLKKIGEYIEKQYKKDKLPIILMGDFNANPNSKLIRNFSNGNYSTNKFIAVQEFKKDIYGISTMSKFRGNKKGYHIDYIFISEEFKIIDTNIIDYNKNGKYPSDHYPVIADLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDA2</accession>
    <name>A0A386PDA2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01920</name>
        <name evidence="4" type="ORF">EI377_12440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678281.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01164"/>
    <dbReference type="EnsemblBacteria" id="AYE33304">
        <property type="protein sequence ID" value="AYE33304"/>
        <property type="gene ID" value="CP523_01920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61474">
        <property type="protein sequence ID" value="QAS61474"/>
        <property type="gene ID" value="EI377_12440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="S1" evidence="2">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="S1" evidence="2">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="280" mass="32297" checksum="80125F50261F10DB" modified="2018-12-05" version="1">MINIGDYNILKVKREKDFGFYLGNEGREEVLLPKAVLEDKSIKEGDEIEVFVYRDSKDRPVATFKKPLAKIGDVAYLKVVGQTKFGAFVDFGLDRDIFVPIKEQRFKLKVGNKYLFYLYLDKTGRLAATTEVENYLENAKEEEMEFKVGDEVIAQVYSRTPSGTLNVAIDSKYKGLVLPNEYYDEVFPGEELYLRIKRLYEDGVVGLTPRKTRLSEREKLQEDIIKYMEKNGGFMEFNDKSKPEDIKATFKTSKNYFKMALGGLMKNGKIVQEEEGTRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDH5</accession>
    <name>A0A386PDH5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34055">
        <property type="protein sequence ID" value="AYE34055"/>
        <property type="gene ID" value="CP523_06015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06015"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="67" mass="7719" checksum="4EA0502FCED966C5" modified="2018-12-05" version="1">MNPEEYGLSGKGYSKASMPNSLSGYLDFMKDIKRYIEKYNIPSMDGGLYESMRNTADDFESELKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDK3</accession>
    <name>A0A386PDK3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium-independent anion transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">SulP family inorganic anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06160</name>
        <name evidence="8" type="ORF">EI377_00640</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01933"/>
    <dbReference type="EnsemblBacteria" id="AYE34083">
        <property type="protein sequence ID" value="AYE34083"/>
        <property type="gene ID" value="CP523_06160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59453">
        <property type="protein sequence ID" value="QAS59453"/>
        <property type="gene ID" value="EI377_00640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="439"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="546" mass="58538" checksum="A8260639D886516E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDW6</accession>
    <name>A0A386PDW6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01753"/>
    <dbReference type="EnsemblBacteria" id="AYE33980">
        <property type="protein sequence ID" value="AYE33980"/>
        <property type="gene ID" value="CP523_05590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="340" mass="39038" checksum="EBEBC236768B596B" modified="2018-12-05" version="1">MNKTNIKCPRCHSNKLYKFGLDKQANQKYQCQNCKRQFAPDKVSSRVLKNYPRCPECGKGTYLHHSYKHYNRYKCNNKKCNHIIVNHHSLNIDNASSEAITSSLSMKGMRFPLHVILTTLTLYFLNNSSTRAISQFLMINSGIKVSHVTIASWTNKFAPFFKQKADKFKASLNLQSDDWHADETVVFINGERYYFWLAIDSETRFILAFHLTKSRSSDSAYTLVNEDKKFGEPVSFITDRLPSYNEAVATLLPNTTHIPVAPMSSDINNNLIESFNKTFKAWYKSKKGFNSFQKANNLIYLFIFHYNFIRPHGSLNNCTPAEVAGFASDSFAKNSWFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDX1</accession>
    <name>A0A386PDX1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_00570</name>
        <name evidence="10" type="ORF">EI377_11060</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676341.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00645"/>
    <dbReference type="EnsemblBacteria" id="AYE33048">
        <property type="protein sequence ID" value="AYE33048"/>
        <property type="gene ID" value="CP523_00570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61217">
        <property type="protein sequence ID" value="QAS61217"/>
        <property type="gene ID" value="EI377_11060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362920" description="Histidine kinase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="847"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1082" mass="124228" checksum="7A4ED14282DD8647" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDY6</accession>
    <name>A0A386PDY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS N-acetylgalactosamine transporter subunit IID</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">PTS system mannose/fructose/sorbose family transporter subunit IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_03930</name>
        <name evidence="11" type="ORF">EI377_14455</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675521.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01556"/>
    <dbReference type="EnsemblBacteria" id="AYE33677">
        <property type="protein sequence ID" value="AYE33677"/>
        <property type="gene ID" value="CP523_03930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62232">
        <property type="protein sequence ID" value="QAS62232"/>
        <property type="gene ID" value="EI377_14455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004704">
        <property type="entry name" value="PTS_IID_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03613">
        <property type="entry name" value="EIID-AGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51108">
        <property type="entry name" value="PTS_EIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS62232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="270" mass="29626" checksum="708CA4469AEC4FEB" modified="2018-12-05" version="1">MESKAVLTRKDYLRTSLRAFWLQNGFNYGNYQGLGYANILYPSLRKIYRNNEEELKNALTDNIEFFNSNPHFLPFITSLHLVMLESGRTSDEARSIKMALMGPLSGIGDSLSQFCLAPLFSTIAASLAQDGMIAGPILFFLAMNGILLTIKLLTGLYGYKLGTSIIETLSDKMSQISAVASMIGVTVISGLAVSFVKINIPIKYVATMPDGAENVVSIQTMLDKIAPALLPAIFTIIVFYLIKKRKWTTYHLVILTIVIGIIGSVLGILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDY8</accession>
    <name>A0A386PDY8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07020</name>
        <name evidence="2" type="ORF">EI377_01765</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673676.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01020"/>
    <dbReference type="EnsemblBacteria" id="AYE34223">
        <property type="protein sequence ID" value="AYE34223"/>
        <property type="gene ID" value="CP523_07020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59628">
        <property type="protein sequence ID" value="QAS59628"/>
        <property type="gene ID" value="EI377_01765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="62" mass="7249" checksum="E12ADBAF1931B033" modified="2018-12-05" version="1">MPAGNGVNCKYCPEYEKKRCNGDDKGCLCYKCPRHLGQCRCVKYCRETESILTFFDEEWDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE25</accession>
    <name>A0A386PE25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_07320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673766.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01081"/>
    <dbReference type="EnsemblBacteria" id="AYE34273">
        <property type="protein sequence ID" value="AYE34273"/>
        <property type="gene ID" value="CP523_07320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="238"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="462"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="676" mass="78338" checksum="5CA38CCD10D0E13B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE46</accession>
    <name>A0A386PE46_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="1">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_01900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EC" id="7.2.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33301">
        <property type="protein sequence ID" value="AYE33301"/>
        <property type="gene ID" value="CP523_01900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01900"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="815"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="846"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="875" mass="95655" checksum="7E790D135FC11C33" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA7</accession>
    <name>A0A386PEA7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_07975</name>
        <name evidence="7" type="ORF">EI377_02735</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675914.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00710"/>
    <dbReference type="EnsemblBacteria" id="AYE34365">
        <property type="protein sequence ID" value="AYE34365"/>
        <property type="gene ID" value="CP523_07975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59771">
        <property type="protein sequence ID" value="QAS59771"/>
        <property type="gene ID" value="EI377_02735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="535" mass="60320" checksum="D2BAA35F7DBBF892" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA8</accession>
    <name>A0A386PEA8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01350</name>
        <name evidence="2" type="ORF">EI377_11850</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675575.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33198">
        <property type="protein sequence ID" value="AYE33198"/>
        <property type="gene ID" value="CP523_01350"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61368">
        <property type="protein sequence ID" value="QAS61368"/>
        <property type="gene ID" value="EI377_11850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01350"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="80" mass="9557" checksum="6DD79422AF9B9606" modified="2018-12-05" version="1">MEIEKLLEKYLRAIGKLTPGDKNFCVVKYDLIEEKDIIYCQYGYTNDEVVNSFRNHNFLDEVKIKLTFDKDNLSMNFLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH5</accession>
    <name>A0A386PEH5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06945</name>
        <name evidence="5" type="ORF">EI377_01430</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673647.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01003"/>
    <dbReference type="EnsemblBacteria" id="AYE34210">
        <property type="protein sequence ID" value="AYE34210"/>
        <property type="gene ID" value="CP523_06945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59575">
        <property type="protein sequence ID" value="QAS59575"/>
        <property type="gene ID" value="EI377_01430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="20098" checksum="477A10AC471DE2F8" modified="2018-12-05" version="1">MNLKTRDLVLVAMFAALTAIGAFITIPLPIVPFTLQYFFCALGAILLGAKRGMLAQVLYVGIGLIGVPVFTRGGGPQYIFQPTFGYLIGFIVAAYIIGYISQEMKDLNIKRIFMACLVGLGAIYLFGCIHMYVIFNFYLGQVMSLWKAISVGIIACLASDLLLTLIISIVGARVVPLLRKLGYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEH7</accession>
    <name>A0A386PEH7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04895</name>
        <name evidence="8" type="ORF">EI377_15405</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01697"/>
    <dbReference type="EnsemblBacteria" id="AYE33857">
        <property type="protein sequence ID" value="AYE33857"/>
        <property type="gene ID" value="CP523_04895"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62002">
        <property type="protein sequence ID" value="QAS62002"/>
        <property type="gene ID" value="EI377_15405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04895"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="812" mass="94065" checksum="B3B874B63F3B4D3C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW7</accession>
    <name>A0A386PEW7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe-S-containing hydro-lyase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fumarate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_09185</name>
        <name evidence="5" type="ORF">EI377_03930</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678343.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03061"/>
    <dbReference type="EnsemblBacteria" id="AYE34583">
        <property type="protein sequence ID" value="AYE34583"/>
        <property type="gene ID" value="CP523_09185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59983">
        <property type="protein sequence ID" value="QAS59983"/>
        <property type="gene ID" value="EI377_03930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09185"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="20260" checksum="CA68FFEE9F2C4253" modified="2018-12-05" version="1">MVKKIQTPLTKEKVKSLKSGDIVLLSGIIYSARDAAHKRFLELLEENEELPLDVKNQIIYYVGPSPAKPGEVIGSAGPTTSYRMDAYTPKLLDLGLIGMIGKGERGQDVIDSIMKNKSIYFGAIGGAAALISQSIVSSEVVAYEDLGAEAIRRLQVKDMPLIVIIDSQGNNLYRHGQDEYLNHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEX9</accession>
    <name>A0A386PEX9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6398 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00540</name>
        <name evidence="4" type="ORF">EI377_11030</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676329.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00637"/>
    <dbReference type="EnsemblBacteria" id="AYE33042">
        <property type="protein sequence ID" value="AYE33042"/>
        <property type="gene ID" value="CP523_00540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61211">
        <property type="protein sequence ID" value="QAS61211"/>
        <property type="gene ID" value="EI377_11030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00540"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045651">
        <property type="entry name" value="DUF6398"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19935">
        <property type="entry name" value="DUF6398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DUF6398" evidence="2">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="400" mass="45739" checksum="5D97A69182D444E3" modified="2018-12-05" version="1">MLKIPTEFEGRYKEIVEIIEVFCKENLNDNYLKLSKDLCKEICVIEENSIKKGKANSWACGIVHALGMKNGLLSGKGNLSIKASELYAAFKISSSTGLSKSKEIRSLINLEDQKWNIDSIEAREEILEEVAATVMEEKVEDVIEDISNLKIEDENLLKAIAIADSAWNQKNFNKKMKLAEEALNLSKDCAEAYIILSYDNSLSYDKQKDLVVKAVEAAKRVIGEENIEKFTGRFLDSEVSKPYFSAKYRLGNVLWNMGDRSGAIVEFKNLIELCPEDNIMIRGALFSWLIIEDRDEDVENLLERFKNDFLTATKYSKALYLFKKGEKLEAERALKIASVKNPFVIDYITKNKRIPKILPELKNLGTEEDAIYYMKNGEMAWNRVEGAIDWVKKFKKNQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF12</accession>
    <name>A0A386PF12_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VanZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33834">
        <property type="protein sequence ID" value="AYE33834"/>
        <property type="gene ID" value="CP523_04775"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="51"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="221" mass="25398" checksum="EA60B0C72921FBFB" modified="2018-12-05" version="1">MNIISTAIFGAIPFYISAIPIILLNMLLISEKRALLNIRFELKEKIAILGFILSIIFVLGITIGNNSSASFDMVRLRSINIIPFKGMNVQYLFALKGDMYSIVNLFGNILIFIPFGFFLSIYYKDDAKERFKIIITAMIISFFIEFLQLFIGRAVDINDIILNTTGVLLGRIIFRYFNIIFGNILNTINLRCINISNNKGVKRIRILQLFLWIIFLVFNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF17</accession>
    <name>A0A386PF17_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsB</name>
        <name evidence="6" type="ORF">CP523_00745</name>
        <name evidence="7" type="ORF">EI377_11240</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674638.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02371"/>
    <dbReference type="EnsemblBacteria" id="AYE33082">
        <property type="protein sequence ID" value="AYE33082"/>
        <property type="gene ID" value="CP523_00745"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61251">
        <property type="protein sequence ID" value="QAS61251"/>
        <property type="gene ID" value="EI377_11240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00745"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="26218" checksum="FE5F626DAB4B5C85" modified="2018-12-05" version="1">MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIFTERNGIYIIDLQKTVKKADEAYNFIKEVATEGKDILFVGTKKQAQEAIKEEAIRSNMHYVNNRWLGGMLTNFKTIRTRINRLEALQTMEQDGTFDVLPKKEVIKLKGEMEKLEKNLGGIRNLDASNIGAMFVVDPRKEKNAISEAKILGIPVVGIVDTNCDPEEVDYVIPGNDDAIRAVKLITAKMADGIIEGRQGEQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF34</accession>
    <name>A0A386PF34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxybutyryl-CoA dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_09575</name>
        <name evidence="8" type="ORF">EI377_04320</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; butanoate metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.157" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676680.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02621"/>
    <dbReference type="EnsemblBacteria" id="AYE34653">
        <property type="protein sequence ID" value="AYE34653"/>
        <property type="gene ID" value="CP523_09575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60052">
        <property type="protein sequence ID" value="QAS60052"/>
        <property type="gene ID" value="EI377_04320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09575"/>
    <dbReference type="UniPathway" id="UPA00863"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008691">
        <property type="term" value="F:3-hydroxybutyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019605">
        <property type="term" value="P:butyrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="5">
        <location>
            <begin position="184"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="282" mass="30715" checksum="C58DE1FE77A2E59C" modified="2018-12-05" version="1">MEKIFVIGAGTMGAGIVQAFAQKGHEVIVRDIKDEFVERGIAGINKGLSKKVAKGKMTEEDKEAILSRITGTTDMKLAEDCDLVIEAAVENMQIKKQIFAELDEICKESTILASNTSSLSITEVASATKRADKVIGMHFFNPAPVMKLVEIIRGMATSQETFDTVKELSVAIGKEPVEVAEAPGFVVNRILIPMINEATFILEEGIASVEDIDTAMKYGANHPMGPLALGDLIGLDVCLAIMDVLYNETGDNKYRASSLLRKYVRAGWLGRKSGKGFYDYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF77</accession>
    <name>A0A386PF77_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_05090</name>
        <name evidence="5" type="ORF">EI377_15650</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676198.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01808"/>
    <dbReference type="EnsemblBacteria" id="AYE33894">
        <property type="protein sequence ID" value="AYE33894"/>
        <property type="gene ID" value="CP523_05090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62045">
        <property type="protein sequence ID" value="QAS62045"/>
        <property type="gene ID" value="EI377_15650"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS62045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="257" mass="29816" checksum="AB87570AA20AB01E" modified="2018-12-05" version="1">MIDLHSHIIYGIDDGSKSKEMTLNMLRKSVETGTRKIVATPHFFPGRYEVKSGDVKEYVKELNALTKENGINIEIYSGQEVYYTENILKYYNEGLIGTINNTRYMLIELPMRNFSRTNVINDIYELQIKGIIPIIAHPERYKPFIEEPRLINKLIREGFLFQLNTGSITGMFGKNAKKTANIFLKNKVYSFIGSDAHRDVKRNTDMSLGLEAINKIDKKYLSEINRWSEDMLLNKDVEFGGNIIEKKKNFILRLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB5</accession>
    <name>A0A386PFB5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hisC</name>
        <name evidence="7" type="ORF">CP523_06400</name>
        <name evidence="8" type="ORF">EI377_00875</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677796.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02439"/>
    <dbReference type="EnsemblBacteria" id="AYE34127">
        <property type="protein sequence ID" value="AYE34127"/>
        <property type="gene ID" value="CP523_06400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59494">
        <property type="protein sequence ID" value="QAS59494"/>
        <property type="gene ID" value="EI377_00875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06400"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="32"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="368" mass="41945" checksum="6E2B5C75CAF67F54" modified="2018-12-05" version="1">MKYRVRNEVKSLAKYVAGKPIEEVKRELGISKVVKLASNENPLGCSPKVIETIKSTLTDVNMYPDASSYEFKKLLSEKLNVNKDMIFCGAGSDSLINVLCTTILDKDDESIMPELTFPRYESNTLLMGAKPVKIPMKNNYLDLEAMVNAITDKTKIIWFCNPNNPTGSMFTAKEFNNIVDKIPEDILIIMDEAYCEYVISSEYPNSIELLKKYPNIIILRTFSKAYGLASLRFGYGIAREEIVDYLNRVINAFDTNLFAQKSAVAALNDEGFLEKVKQYNYNQREYLSIQFEKMGLEYVKSEANFILVNVKGDDKPIHEYLLKHGYIIRPGFLLGIPGFIRVSIGTEEENKEFCKLLFLAIQERDLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD5</accession>
    <name>A0A386PFD5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ORF">CP523_10235</name>
        <name evidence="4" type="ORF">EI377_05040</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674311.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01448"/>
    <dbReference type="EnsemblBacteria" id="AYE34753">
        <property type="protein sequence ID" value="AYE34753"/>
        <property type="gene ID" value="CP523_10235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60153">
        <property type="protein sequence ID" value="QAS60153"/>
        <property type="gene ID" value="EI377_05040"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="208"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="344" mass="36778" checksum="73E1091225D634FB" modified="2018-12-05" version="1">MWFWRRGTDLGIDLGTATVLVYVKGKGVILKEPSVVAINKSNNKVLAAGEEARKMIGRTPGNIVAVRPLRNGVISDYDITEKMLKEFIKKAYGKAKITAPKVMVCVPSQATEVEKRAVMDATTNLGAKRVHLIEEPLAAAIGVGLDITKPNGSMVVDIGGGTTDIAVISLGGVVVRSSIKVAGDTFDDAIIKYVRSKYKIMIGEKTAEELKVNIGSVFKGSRDLVTTMKGRNLVTGLPDEVSISTDEIREALKESVGLIVEQVKFVLERTPPELAADIIEKGILMTGGGSLLDGLDKVIQNETGVSVSIADNSVEAVVEGTGEVLRYLDKIDSSLIGQEITLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFF8</accession>
    <name>A0A386PFF8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">CP523_08970</name>
        <name evidence="7" type="ORF">EI377_03715</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021876938.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00234"/>
    <dbReference type="EnsemblBacteria" id="AYE34540">
        <property type="protein sequence ID" value="AYE34540"/>
        <property type="gene ID" value="CP523_08970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59940">
        <property type="protein sequence ID" value="QAS59940"/>
        <property type="gene ID" value="EI377_03715"/>
    </dbReference>
    <dbReference type="GeneID" id="66570339"/>
    <dbReference type="KEGG" id="csep:CP523_08970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="102" mass="11482" checksum="43DAFE7BF50CB789" modified="2018-12-05" version="1">MSKQKIRIRLKAFDHTILDQSAEKIVETAKSTGAKVAGPVPLPTEKDVVTILRAVHKYKDSREQFEIRTHKRLIDIVNPSPKTVDALMRLNLPAGVDIEIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM6</accession>
    <name>A0A386PFM6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_10800</name>
        <name evidence="12" type="ORF">EI377_05585</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677599.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02494"/>
    <dbReference type="EnsemblBacteria" id="AYE34853">
        <property type="protein sequence ID" value="AYE34853"/>
        <property type="gene ID" value="CP523_10800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60247">
        <property type="protein sequence ID" value="QAS60247"/>
        <property type="gene ID" value="EI377_05585"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10800"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="382"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="668" mass="74240" checksum="6F6CAC5CDF12306C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR6</accession>
    <name>A0A386PFR6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rluF</name>
        <name evidence="5" type="ORF">CP523_09510</name>
        <name evidence="6" type="ORF">EI377_04255</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34640">
        <property type="protein sequence ID" value="AYE34640"/>
        <property type="gene ID" value="CP523_09510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60039">
        <property type="protein sequence ID" value="QAS60039"/>
        <property type="gene ID" value="EI377_04255"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="259" mass="29431" checksum="9FF7EA9C6478570C" modified="2018-12-05" version="1">MKKIPKENNSIIIHDDRGDSIRLNKYISETGMCSRREADKLIESGRVTIDGEKASMGTRVLSNQKVKVDGKLIRKEEELVYIALNKPVGITCTTEKKIKGNIVDFIKHDKRIFHIGRLDKDSQGLILLTNDGDIVNKILRAGNNHEKEYIVTVDKPIDDKFIKSMANGVEILGTVTKKCIVTKEGERTFRIILTQGMNRQIRRMTSALGYNVVKLKRIRIMNIKLGNLKIGEWRDLTNEELRSLGMLIKNSGKTKEVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFT9</accession>
    <name>A0A386PFT9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06270</name>
        <name evidence="4" type="ORF">EI377_00745</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677753.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02413"/>
    <dbReference type="EnsemblBacteria" id="AYE34104">
        <property type="protein sequence ID" value="AYE34104"/>
        <property type="gene ID" value="CP523_06270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59471">
        <property type="protein sequence ID" value="QAS59471"/>
        <property type="gene ID" value="EI377_00745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="8756" checksum="99DCEA93BC17F5BF" modified="2018-12-05" version="1">MKELLEILENIDPDINYETEDKLIDNGCLDSLSILSLVTELEDAFEIEIKPVDLIPTNFNSAKAMWSMIQRLQKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV5</accession>
    <name>A0A386PFV5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11210</name>
        <name evidence="3" type="ORF">EI377_06000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677047.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34935">
        <property type="protein sequence ID" value="AYE34935"/>
        <property type="gene ID" value="CP523_11210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60329">
        <property type="protein sequence ID" value="QAS60329"/>
        <property type="gene ID" value="EI377_06000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="219" mass="25784" checksum="E03272BF7BC9DE11" modified="2018-12-05" version="1">MKAFKFSKNNSILFIVGVLLVSLIVNVYMSILNTNYRYEVKKQSYNNIEEIRHRNESILLILDQGIKAGSISNEELLNLYKGYNSISKALTDLWSQYNDYSNQSFISLNKKTIKDTKPNEICERIESLVFEYLNLEMRTLNDKLILKNKVLKDFETMKNMSSDLEGFYKEFNEFVLKTTDESKRKSKFIKNDYWIDALNGINNTIETYINYDFTIEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV6</accession>
    <name>A0A386PFV6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04405</name>
        <name evidence="3" type="ORF">EI377_14950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00397"/>
    <dbReference type="EnsemblBacteria" id="AYE33768">
        <property type="protein sequence ID" value="AYE33768"/>
        <property type="gene ID" value="CP523_04405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61926">
        <property type="protein sequence ID" value="QAS61926"/>
        <property type="gene ID" value="EI377_14950"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024008">
        <property type="entry name" value="CHP04090"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023833">
        <property type="entry name" value="Signal_peptide_camelysin"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04088">
        <property type="entry name" value="cognate_SipW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04090">
        <property type="entry name" value="exp_by_SipW_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788364" evidence="1">
        <location>
            <begin position="30"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="23692" checksum="48069275E19823E7" modified="2018-12-05" version="1">MVKRKGIGKIIIALGVTAILVGGTLAWFASSDTVINKFSTGSVPGDLNSGVDIWEKFNEESAKNIVPGTIVEKLVQAKNTASYNSFIRVKIEKEFLGTNNANLSTDMIKLDFGDNLTTEPSNGKWVDEKDGYYYYIDKIAPGKFTNALLKNVELSTEAGNAYKNATFNVKIIAESIQSSNNAHETGWSTSSEAVKAKLTELGAESVVAGGNDASEPGAIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY8</accession>
    <name>A0A386PFY8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_07930</name>
        <name evidence="6" type="ORF">EI377_02690</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675900.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00701"/>
    <dbReference type="EnsemblBacteria" id="AYE34357">
        <property type="protein sequence ID" value="AYE34357"/>
        <property type="gene ID" value="CP523_07930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59762">
        <property type="protein sequence ID" value="QAS59762"/>
        <property type="gene ID" value="EI377_02690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="256" mass="28767" checksum="90EA62E465B1E19E" modified="2018-12-05" version="1">MIKANDLKLCYDEKIILDNINLDIEEGKITALIGSNGCGKSTLIKSIARILTPKSGTVLMKDKNILKIPSKEVSRLLSMLPQNSNAPEDLTVYDLVKQGRYPYHNLLSFWSKKDEKIVLEAISKMGLVNEKNVTLGNLSGGQRQRAWIALALAQDTEIILLDEPTNHLDIKYQLEILNILKELNEKENRTIVMVIHDINHALKYAHNIVALKDGDIFAQGNKESIINEDLIKSVFDIKCKLIDSPVDSCKMCVPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ0</accession>
    <name>A0A386PFZ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11430</name>
        <name evidence="3" type="ORF">EI377_06245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02843"/>
    <dbReference type="EnsemblBacteria" id="AYE34975">
        <property type="protein sequence ID" value="AYE34975"/>
        <property type="gene ID" value="CP523_11430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60368">
        <property type="protein sequence ID" value="QAS60368"/>
        <property type="gene ID" value="EI377_06245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="463" mass="49631" checksum="88E20CA10062AC9B" modified="2018-12-05" version="1">MTLSLLHYVYIVFTILILIWIFRKRDITIICIIGIFLMAILSSRSLPLSIMSIFNGFSYAIVELLPVILIISIITAFSKLLSATEINEMMIKPLTKFIKNKSLAYWIIGISMMIISWFFWPSPAVALIGAVLIPVAKKAGLPSLATAMAMNLFGHGIALSSDIIIQGASKLTANAAGISIDELYSSLIPLEIVMGLTTTIIAYFIIMKDIKNNNMVQENNSDNKSKAKDKPLNKLSDRKKRFYALLVFLGYLFDVILMCVFSIKGGDATALVGGTTLFLLIVIFLGSFKFNSVQQITPYITDGFQFAFKVFGAVIPVATFFYIGGSGFSDILGVTLPANSQGIINDLGIALANAVPLNKAVATATVSGVGILTGLDGSGFSGLSLVGSSAMLFSSSVAVNTSTLASLGQICTIWIGGGTLIPWALIPVAAICDVSPFDLARKNIIPVTIGLITTLIYAIIFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ1</accession>
    <name>A0A386PFZ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34963">
        <property type="protein sequence ID" value="AYE34963"/>
        <property type="gene ID" value="CP523_11370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="44" mass="5495" checksum="5C03188AB5778848" modified="2018-12-05" version="1">MKVIRKELAKLYRFFYSIFWGFYFSASYLFCKNKYKSFLMSIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG01</accession>
    <name>A0A386PG01_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA1(Val) (Adenine(37)-N6)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06585</name>
        <name evidence="3" type="ORF">EI377_01075</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677479.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02194"/>
    <dbReference type="EnsemblBacteria" id="AYE34164">
        <property type="protein sequence ID" value="AYE34164"/>
        <property type="gene ID" value="CP523_06585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59532">
        <property type="protein sequence ID" value="QAS59532"/>
        <property type="gene ID" value="EI377_01075"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="49"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="249" mass="28563" checksum="80F495730159E7EE" modified="2018-12-05" version="1">MEERVQLLEDESIDDLQLKNLYLIQKKNAFRFGVDAVLLSDFANVKTKHRVIDICTGTGIVPFLIYGKYSPKSIVGLEIQEEMVEMAKRSAKYNNLEEIITFNQGDLKNKKLLDSLGKFDVLTVNPPYKLNNAGILNPNDKLAIARHEIMCTLEDVIIASRRLLKDNGRMYIVHRPERLIDIFELMRKHKIEPKRVKMVQPNAKKAPNIVLVEGQRDGGAFLKWEAPLCVYNEDGTYTKELNEIYGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG23</accession>
    <name>A0A386PG23_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675977.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00742"/>
    <dbReference type="EnsemblBacteria" id="AYE34397">
        <property type="protein sequence ID" value="AYE34397"/>
        <property type="gene ID" value="CP523_08140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017471137" evidence="1">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="360" mass="40075" checksum="B47F86371A68555F" modified="2018-12-05" version="1">MKRKCNISKLLIIFLIPTIFVGCLDKNNQSNKDINIFNSKEALNVAKKYLDFVVVGDLIGANSLCKDDLLEANKNISTGTSKVISYAQENFIESGNSAYGIFNVIRSSDSEPKCDLDSFSIKVNQIGKEYKISEIKAVNKGQVYVKNNNLRMIGEDGGKSDLVVKLTDMPKDIYPRENKIMLYKEPSPNKAFGIVALSYKGEKIAISTLGEDSVFISVAYIENSKQTVGSSGSSTSNNAEAEQSLEGLLEKPIAKKVVPLDILRNISVNNFIFTQEEEELIIEFTNESSVNRIKLYKTDDGTPIDLGLDDIFDNAKYNIKVIALDKNKVFIKVDKANNNEDDSLLGEYKIDMEKLKITKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG27</accession>
    <name>A0A386PG27_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">atpF</name>
        <name evidence="14" type="ORF">CP523_10170</name>
        <name evidence="15" type="ORF">EI377_04985</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676636.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00363"/>
    <dbReference type="EnsemblBacteria" id="AYE34740">
        <property type="protein sequence ID" value="AYE34740"/>
        <property type="gene ID" value="CP523_10170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60142">
        <property type="protein sequence ID" value="QAS60142"/>
        <property type="gene ID" value="EI377_04985"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE34740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS60142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="159" mass="18574" checksum="88869E1CBDB493FA" modified="2018-12-05" version="1">MDIDKSVIIATIINFIILLAILKHFFFDKVKAIIEERENDITTQLDNAEEELEKARMLAIENERVLKGAREEGKKITERHKEKAEKIYEEIIDEANQEAKVILERAKVEINREKEKVEYQLKKEAIDLAIELSKKVIEKNINEQDNRDLIGDFINKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG61</accession>
    <name>A0A386PG61_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pro-sigmaK processing inhibitor BofA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bofA</name>
        <name evidence="2" type="ORF">CP523_07025</name>
        <name evidence="3" type="ORF">EI377_01770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673678.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01021"/>
    <dbReference type="EnsemblBacteria" id="AYE34224">
        <property type="protein sequence ID" value="AYE34224"/>
        <property type="gene ID" value="CP523_07025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59629">
        <property type="protein sequence ID" value="QAS59629"/>
        <property type="gene ID" value="EI377_01770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010001">
        <property type="entry name" value="BofA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07441">
        <property type="entry name" value="BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02862">
        <property type="entry name" value="spore_BofA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="82" mass="9036" checksum="7962BCCD2F795CB2" modified="2018-12-05" version="1">MDYRMMVYALVGLLLLYVVIKFLKWPLKILINGVIGIVLLYIANFIGGYLGFAIGINAVTALIAGFLGVPGVIFLIIFQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG64</accession>
    <name>A0A386PG64_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_01205</name>
        <name evidence="6" type="ORF">EI377_11705</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674376.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02277"/>
    <dbReference type="EnsemblBacteria" id="AYE33169">
        <property type="protein sequence ID" value="AYE33169"/>
        <property type="gene ID" value="CP523_01205"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61339">
        <property type="protein sequence ID" value="QAS61339"/>
        <property type="gene ID" value="EI377_11705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01205"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="5"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="4">
        <location>
            <begin position="456"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="874" mass="95471" checksum="D981A1F48F53E7D0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG69</accession>
    <name>A0A386PG69_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_05000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the internalin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33878">
        <property type="protein sequence ID" value="AYE33878"/>
        <property type="gene ID" value="CP523_05000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05000"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012569">
        <property type="entry name" value="LRR-contain_adjacent_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08191">
        <property type="entry name" value="LRR_adjacent"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017406988" evidence="5">
        <location>
            <begin position="28"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="LRR_adjacent" evidence="6">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="LRR_adjacent" evidence="6">
        <location>
            <begin position="731"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="836" mass="94866" checksum="B50CD88C59BB5F5E" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG91</accession>
    <name>A0A386PG91_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2922 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05110</name>
        <name evidence="2" type="ORF">EI377_15670</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676203.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01812"/>
    <dbReference type="EnsemblBacteria" id="AYE33898">
        <property type="protein sequence ID" value="AYE33898"/>
        <property type="gene ID" value="CP523_05110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62049">
        <property type="protein sequence ID" value="QAS62049"/>
        <property type="gene ID" value="EI377_15670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05110"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021321">
        <property type="entry name" value="DUF2922"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11148">
        <property type="entry name" value="DUF2922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="7883" checksum="E91F9D97FC0A9B4A" modified="2018-12-05" version="1">MATTVVMGFKDPVDRTVRLSVRDVKSDVNDTEINALMDKIIETKTIETEAGALASKVKAEIVVREVTEVSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF9</accession>
    <name>A0A386PGF9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3343 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07585</name>
        <name evidence="3" type="ORF">EI377_02275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01126"/>
    <dbReference type="EnsemblBacteria" id="AYE34314">
        <property type="protein sequence ID" value="AYE34314"/>
        <property type="gene ID" value="CP523_07585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59708">
        <property type="protein sequence ID" value="QAS59708"/>
        <property type="gene ID" value="EI377_02275"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
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        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="79" mass="9263" checksum="45558D14DAA3D4D7" modified="2018-12-05" version="1">MNYYIIVFKNTLDAMTAENNLLKEEIEFKMMPTPTVITQSCGLCVRIENKEYVEKIISESIINYKKIYIKTESGYNQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH5</accession>
    <name>A0A386PGH5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GHKL domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04345</name>
        <name evidence="4" type="ORF">EI377_14880</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676465.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00409"/>
    <dbReference type="EnsemblBacteria" id="AYE33756">
        <property type="protein sequence ID" value="AYE33756"/>
        <property type="gene ID" value="CP523_04345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61913">
        <property type="protein sequence ID" value="QAS61913"/>
        <property type="gene ID" value="EI377_14880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04345"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="332"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="434" mass="50787" checksum="3F332B4F13C4713A" modified="2018-12-05" version="1">MRIIVGMQIISFLLIASINIYKLNLLFEPRFNKVINSAILFISLFLVMIGLNIYVNSFISYYFLLVFLFPCVVLLFFKGNKYLIVLLNNITMLIIINSQSIVLSLSIIFRKTSLYKLYLYDKLNLLTTITLVIIISAELFITIFIKMKFSLEYCPKKSSLLIMNITLFSKVIVNLLLLFYLFYSKLYIEFAKFVLLFTIVGIGTDFYIIWLSIKNNKAEDREKELTILNEQVKYQYEHYKDLEAYYKDVRRIWHDINNHKNVISVLIENRQYVELENYMNDINDYLKELDKNMFISKNKIVEAICLNKAKLCREKNIDIEFNINIPEVLSIRDIDLCAIYGNVLDNGIEACERVESGREKKIKVESCVKDGYLSLFVVNTKELKKAVIGATSKEDRLKHGIGLESIKKSVSKYSGHLMLKDKWETFEVRVILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ8</accession>
    <name>A0A386PGJ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676426.1">
        <property type="nucleotide sequence ID" value="NZ_CP023671.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33776">
        <property type="protein sequence ID" value="AYE33776"/>
        <property type="gene ID" value="CP523_04445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="78" mass="9259" checksum="C4F4DD4C785147E6" modified="2018-12-05" version="1">MDIILDLIILTFVIYLFLKKRSIFLLSLSFFYIIELFIDMFSSYLASFAVTFLNISQFITLLLTIVIFIFPKIIHRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM0</accession>
    <name>A0A386PGM0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Damage-inducible protein CinA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nicotinamide-nucleotide amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06700</name>
        <name evidence="3" type="ORF">EI377_01165</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679206.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00031"/>
    <dbReference type="EnsemblBacteria" id="AYE34181">
        <property type="protein sequence ID" value="AYE34181"/>
        <property type="gene ID" value="CP523_06700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59544">
        <property type="protein sequence ID" value="QAS59544"/>
        <property type="gene ID" value="EI377_01165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="162" mass="17463" checksum="F6F8C5F0C42A7351" modified="2018-12-05" version="1">MSNNGNDRSIEYIVGKILCKNKLTISTAESCTGGLVAGKLISYPGISEVFKEGVVTYSNESKMKRLGVKEETLRSFGAVSEETAREMAEGIAREAKTDVSVVTTGIAGPGGGTKEKPVGLVYIGVYVKGKTQVKKFNFKGDRQQVREEAVLSALNMLKHNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGQ7</accession>
    <name>A0A386PGQ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33816">
        <property type="protein sequence ID" value="AYE33816"/>
        <property type="gene ID" value="CP523_04680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04680"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="182" mass="21750" checksum="02DAC7A5A1B6A105" modified="2018-12-05" version="1">MGKSWTGLRKELEEEFLCESLRGRVQYFLTHYHGAPDNYGRFCVRVDKNEYAMANPYAYYVKGYSNLEYLTKQELDIPERKWTDKGYLYDEENKAIEDEVVNISINNGDFDIYNITDAIREYKELPIVKSIVSENPIVRMFAVMDRRIGKRTLKKLAEEVDTQPKWLQFFYKLRLDSENIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT6</accession>
    <name>A0A386PGT6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Recombinase RecT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13090</name>
        <name evidence="2" type="ORF">EI377_07960</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677844.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02559"/>
    <dbReference type="EnsemblBacteria" id="AYE35283">
        <property type="protein sequence ID" value="AYE35283"/>
        <property type="gene ID" value="CP523_13090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60677">
        <property type="protein sequence ID" value="QAS60677"/>
        <property type="gene ID" value="EI377_07960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018330">
        <property type="entry name" value="RecT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03837">
        <property type="entry name" value="RecT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="297" mass="33626" checksum="8E7B7BB92081E718" modified="2018-12-05" version="1">MEKNKIQTTQERNITDGVLNRIKVLEKEGEINFPSNYSYQNALKSAHLILSEQTVKKGNVNIPVLEACTKASVINALLDMTIQGLSPIKKQCYFIPMGDKLTLMKSYMGNIASVKRLKGVKEVFANVIYSGDEFEYKLNLKTGCKEIIKHEQKFENIDTTKIKGAYAIVVRENGPDYVEVMNISQIKNSWNQGNAKGQSLAHKNFSDEMAKKTVINRACKNFLNTSDDSDLLIAAINRTKDYDPEDIIEVTKKEVDKEIMEEANKEVIDVEIEESIDSDIIEEVQAEVVHDDMECDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT8</accession>
    <name>A0A386PGT8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS trehalose transporter subunit IIBC</fullName>
            <ecNumber evidence="16">2.7.1.201</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">treB</name>
        <name evidence="15" type="ORF">CP523_07260</name>
        <name evidence="16" type="ORF">EI377_02015</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.201" evidence="16"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673747.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01069"/>
    <dbReference type="EnsemblBacteria" id="AYE34261">
        <property type="protein sequence ID" value="AYE34261"/>
        <property type="gene ID" value="CP523_07260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59668">
        <property type="protein sequence ID" value="QAS59668"/>
        <property type="gene ID" value="EI377_02015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015574">
        <property type="term" value="F:trehalose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011296">
        <property type="entry name" value="PTS_IIBC_treh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01992">
        <property type="entry name" value="PTS-IIBC-Tre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="13">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="14">
        <location>
            <begin position="107"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS59668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="470" mass="50451" checksum="2E763EFD0C0513BC" modified="2018-12-05" version="1">MGKFIDDSKALLEYVGGKENIGAVTHCVTRMRFVLKDTSLANKEKIESLKSVKGTFIQAGQFQVIIGNSVGDFYNDFVKISGVEGTSKDDVKDAAKSNMTFMQRLMANLAEIFSPLIPAIIVGGLILGFRNLIGDIKFFEDGTKSLIEISQFWAGTHSFLWLIGEAIFHFLPVGITWAITKKMGTTQILGIVLGITLVSPQLLNAYAVSSGGEIPVWDFGFAQVNMIGYQAQVIPAILAGFLLVYLEKFFRKITPASISMIIVPFFALVPTVLIAHVVLGPIGWTIGSWISTVVYAGLTSSFRWLFAGIFGFAYAPLVITGLHHMTNAIDLQLMAQVGGTSLWPMIALSNIAQGSAVLAMIYLHRKSEEEKQVSIPACISAYLGVTEPALFGINLKYGFPFISGMIGSGIAAIISVGSGVMANAIGIGGIPGILSIQPNSIPMFAVSMVVAIVVPFILTVVIGRKKINVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH17</accession>
    <name>A0A386PH17_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family intramembrane serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02860</name>
        <name evidence="8" type="ORF">EI377_13385</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677002.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00978"/>
    <dbReference type="EnsemblBacteria" id="AYE33479">
        <property type="protein sequence ID" value="AYE33479"/>
        <property type="gene ID" value="CP523_02860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61650">
        <property type="protein sequence ID" value="QAS61650"/>
        <property type="gene ID" value="EI377_13385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="181"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="322" mass="36029" checksum="AEF52491E0B8DC21" modified="2018-12-05" version="1">MEKFEKVFYNLLTKNAGFFMKNYYSEFHKKTKWIGILDLGNSVLGVIVTGDDEEDINYREAKEYLTGAFNKPQILNSVILASGEYIENKISSNEDKLIFSLKDRKIIYCSQSAKPLIPIIEYIVKIDTSPKDKLNKYKFTYTLIVVNILIYMISAIKAKNIIYIDIGTLIQMGAKVNPLINQGQIYRLITSAFLHGGIIHITFNMMALKIIGVQVEEIYGRKKYAVIYFLSAIGSSFLSYLFSQSSVSVGASGAVFGLLGAMLIFAFNKRKTIGKEYMMNIIQVIILNIVIGLTATNIDNFGHIGGLIVGILVAGIFAINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH94</accession>
    <name>A0A386PH94_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34431">
        <property type="protein sequence ID" value="AYE34431"/>
        <property type="gene ID" value="CP523_08320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="181" mass="21372" checksum="ECF99C747781F036" modified="2018-12-05" version="1">MSINKKKIYIFTVLLSLMFILVCMKQLFKNDIRKIALLNNEIRAFKEVDLENGKYKIVLPEKWSVNERNKNIDGVEFEATINDNNKIDGTISILDGVNDLNNIPDTIFKDVKNRKCKVYDEYGVKWHVLEYKMPYDNKYKNICYFKEYSKGKILIISFHFDESQYKPSIKVAFDEVAKGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB3</accession>
    <name>A0A386PHB3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
            <shortName evidence="9">ECF transporter T component EcfT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ecfT</name>
        <name evidence="10" type="ORF">CP523_09140</name>
        <name evidence="11" type="ORF">EI377_03885</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the energy-coupling factor EcfT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678398.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00266"/>
    <dbReference type="EnsemblBacteria" id="AYE34574">
        <property type="protein sequence ID" value="AYE34574"/>
        <property type="gene ID" value="CP523_09140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59974">
        <property type="protein sequence ID" value="QAS59974"/>
        <property type="gene ID" value="EI377_03885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01461">
        <property type="entry name" value="EcfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024919">
        <property type="entry name" value="EcfT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="30007" checksum="CF93525D81048631" modified="2018-12-05" version="1">MIKDITIGQYIPGETFVHKLDPRTKILLSILFIVSLFIVDKFIGYIFIIGFLALTVYVAQIPPRYLYKGLKPVFFLIAFTAILNIFMIKGSYDTLIFELGFLKIYKEGLTTAAFMALRLIFLIMGTSVLTLTTSPIELTDGIEKLLKPIGKELAHELAMMMTIALRFIPTLMDETDKIMMAQKARGADFETGGLIQKAKSLIPLLVPLFISSFRRADELAMAMEARAYRGGNGRTRMKQLNFTSKDTVAFVVFGVLLVCSLSIRFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC3</accession>
    <name>A0A386PHC3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE33962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33962">
        <property type="protein sequence ID" value="AYE33962"/>
        <property type="gene ID" value="CP523_05480"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05480"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="128" mass="14702" checksum="33936A0ACE0D17D3" modified="2018-12-05" version="1">MKNGLYAIYNGREYEAGVKEDGSITLRSNDSNDLKNGFTLYKNIIYIKRVKSNEVESIYSTITYADYNGCKCQVIKEIDDKLLLNAILGDYKIFVSLGFDMVDRGVYNKWVNAKDVERVYEIREAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHC8</accession>
    <name>A0A386PHC8_CLOSE</name>
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        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12640</name>
        <name evidence="10" type="ORF">EI377_07545</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01983"/>
    <dbReference type="EnsemblBacteria" id="AYE35200">
        <property type="protein sequence ID" value="AYE35200"/>
        <property type="gene ID" value="CP523_12640"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60603">
        <property type="protein sequence ID" value="QAS60603"/>
        <property type="gene ID" value="EI377_07545"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12640"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
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    <dbReference type="InterPro" id="IPR035965">
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    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
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        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
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        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="277"/>
            <end position="499"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60603.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="529" mass="61688" checksum="90E8F677DB84C146" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHD8</accession>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">EI377_07595</name>
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        <lineage>
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            <taxon>Clostridium</taxon>
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                <person name="Seyboldt C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60612.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="189" mass="22626" checksum="F56B819237375E0D" modified="2018-12-05" version="1">MVIKLKNNVEDVETFLKYYYLNHFGWKIYSNSLYIIGVLNPIIVNIYDTKRNIEFYSNTSMMILNILITIGMTLFFIYLFLKLIPKLLMKRLKKRSIKYYKKKKFFSVEKIIEIKNEYIEVNYDNKKLIIPLNKDILVDEFNGSIIISAKFLKNKIKKVYPLVIPVTIFESIENKEGFIKNIEEKKMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CP523_05845</name>
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    </gene>
    <organism evidence="2 4">
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    <reference evidence="4" key="1">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01872"/>
    <dbReference type="EnsemblBacteria" id="AYE34022">
        <property type="protein sequence ID" value="AYE34022"/>
        <property type="gene ID" value="CP523_05845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59394">
        <property type="protein sequence ID" value="QAS59394"/>
        <property type="gene ID" value="EI377_00330"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="28966" checksum="2CEE5EB257E72308" modified="2018-12-05" version="1">MNIVVCIKQVPGTSKVEVDEKTGVLKRDGIDSKMNPYDLYALETALQIKNKVGGTIKVISMGPPQAMDVIKEAFAMGADEGTLVSDRKFAGADVLATSYTLSQGVRKVGDMDLIICGKQTTDGDTAQVGPEMAEYLGIPHVANVRQILGLNEKSITVEMDMPDTVEVSEVKFPCLITVEKDIFQPRLPSYKRMLETKGRKIDMIALKDFEDKDEKKYGLNGSPTQVERIFPPASNDAHEMWNGQSEELTEKMSSKLKELKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP8</accession>
    <name>A0A386PHP8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein CP523_06395</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rapZ</name>
        <name evidence="2" type="ORF">CP523_06395</name>
        <name evidence="3" type="ORF">EI377_00870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677794.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02438"/>
    <dbReference type="EnsemblBacteria" id="AYE34126">
        <property type="protein sequence ID" value="AYE34126"/>
        <property type="gene ID" value="CP523_06395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59493">
        <property type="protein sequence ID" value="QAS59493"/>
        <property type="gene ID" value="EI377_00870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="294" mass="33598" checksum="0AFB53E2548C4B41" modified="2018-12-05" version="1">MRFIIVTGLSGAGKTEATRSLEDMGYFCVDNLPPKLIPKFAEACVQSQGKIDKVALVIDIRGGIFFDDLFESLNYLKDQEFKYEILFLDASDEVLVKRFKESRRSHPLSPGSRVITGITEERKKLREVKDRADIIIDTSKYAIRDLREEMNKNYGDAKQPEKQLSVTVLSFGFKYGIPVDSDLVFDVRFIPNPFYIPELKPYSGNDKPVKDYVLKQEETVNFVKKATDMLDFLIPNYKKEGKRQLIISIGCTGGRHRSVAIANAIYENLIEKNYNASVEHRDIREDVHKGAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ9</accession>
    <name>A0A386PHQ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YegS/Rv2252/BmrU family lipid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04090</name>
        <name evidence="4" type="ORF">EI377_14610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676898.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02767"/>
    <dbReference type="EnsemblBacteria" id="AYE33709">
        <property type="protein sequence ID" value="AYE33709"/>
        <property type="gene ID" value="CP523_04090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61864">
        <property type="protein sequence ID" value="QAS61864"/>
        <property type="gene ID" value="EI377_14610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="295" mass="32870" checksum="F85C811EAD007C7B" modified="2018-12-05" version="1">MKKVKFIYNPYSGENAILDKLDKIIKIHQEAGYTIIPYRIERDVDVIKAFEDFKESSYYYVLIAGGDGTIDTVVNAMAKCGISIPIGILPVGTANDFGKFLGMPSDIVKACKQILESEVTTVDLGSINDKYFVNVASTGLFTDISQKTDVNLKNTIGKLAYYLKGLEELPNFRKLKIRIHSEECHYDGQIYFMLVFNGQTAGNFKLATRADASDGMLDVIIFKAIPIIELIPLFVKVLKGEHLDSNNVIYFKTNNLFIECDENIVTDIDGEKGPDFPLNIKCIKGGLKILGVKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHV2</accession>
    <name>A0A386PHV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_06575</name>
        <name evidence="4" type="ORF">EI377_01065</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677473.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02192"/>
    <dbReference type="EnsemblBacteria" id="AYE34162">
        <property type="protein sequence ID" value="AYE34162"/>
        <property type="gene ID" value="CP523_06575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59530">
        <property type="protein sequence ID" value="QAS59530"/>
        <property type="gene ID" value="EI377_01065"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06575"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="79" mass="9028" checksum="9A904C69052ADE2A" modified="2018-12-05" version="1">MKSTGVVRRVDELGRIVIPIELRRTLDIAEKDALEIYVDGEQIILKKYEPACIFCGDARDVVNYKGKNICEKCLTELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHX8</accession>
    <name>A0A386PHX8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09725</name>
        <name evidence="3" type="ORF">EI377_04525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676736.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34681">
        <property type="protein sequence ID" value="AYE34681"/>
        <property type="gene ID" value="CP523_09725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60082">
        <property type="protein sequence ID" value="QAS60082"/>
        <property type="gene ID" value="EI377_04525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="95" mass="11365" checksum="EC43E65CDFA75FCE" modified="2018-12-05" version="1">MRRLRLKDIFTFICTLAVIITSIIIICTFLTIYQFYIVGQMFNSYFLLQLATAITMVLWSIRFFIYRKGKERYIYSGAFMLIAIIFMFFIVNLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ5</accession>
    <name>A0A386PHZ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13825</name>
        <name evidence="3" type="ORF">EI377_08720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677129.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02057"/>
    <dbReference type="EnsemblBacteria" id="AYE35420">
        <property type="protein sequence ID" value="AYE35420"/>
        <property type="gene ID" value="CP523_13825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60808">
        <property type="protein sequence ID" value="QAS60808"/>
        <property type="gene ID" value="EI377_08720"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="124" mass="14312" checksum="ED29BA64A9A9AB60" modified="2018-12-05" version="1">MTTFADRLKEERTKKNLTQSELATILYLGQTSVSKYENGKQIPETPTLQKIADFFEVSVDYLLGKTNIRNYEEITTEDKINKLVEESGINTIAAHFKGEKFTEDDLEDIENFINFVLAKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI55</accession>
    <name>A0A386PI55_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1540 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15750</name>
        <name evidence="3" type="ORF">EI377_10465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678915.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35773">
        <property type="protein sequence ID" value="AYE35773"/>
        <property type="gene ID" value="CP523_15750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61111">
        <property type="protein sequence ID" value="QAS61111"/>
        <property type="gene ID" value="EI377_10465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15750"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="123" mass="14349" checksum="387EB4EAD9A49518" modified="2018-12-05" version="1">MNKLSCNVRKCNHNLFGICDMHTIRVLSCSNEKYHGSKCFSFEKFKLSKRVKMIGKIDFYRDMLNDIDSSNSKIELPHIYYELINCKYNESSICKSKTVMIEGFKAKECEGIKCKTFLINSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI66</accession>
    <name>A0A386PI66_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_10355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34771">
        <property type="protein sequence ID" value="AYE34771"/>
        <property type="gene ID" value="CP523_10355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="340" mass="39615" checksum="878E5AE0235BC437" modified="2018-12-05" version="1">MNKTNIKCPRCHSNKLYKFGLDKQPNQKYQCQNCKRQFAPDKVSSRVLKNYPRCPKCGKGTYLHHSYKHYNRYKCNNKKCNHIIVNHHNFNIDPASSEAITGSLSMKGMRFPLQVIITALTLYYLNNTSTRAISQFLMSTFNIKVSHVTVANWSNKFAPYFKLKVDKFKHQVDLQSDDWHADETIVFINGIKHYLWLVIDSETRFIVSFHLSKYRDENSAFSLINEVKKYGSPFNLVTDRWPAYNEAIATLLPNTKHLPVKPMSSYINNNLIESFNKTFKAWYKSKKGFNSFEKANNLIFMFIFHYNFIRPHGSLNNLTPAEVAGFASNNITRQSWFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ0</accession>
    <name>A0A386PIJ0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homocitrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nifV</name>
        <name evidence="4" type="ORF">CP523_08375</name>
        <name evidence="5" type="ORF">EI377_03120</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a Fe-Mo-cofactor biosynthetic component.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674781.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01616"/>
    <dbReference type="EnsemblBacteria" id="AYE34442">
        <property type="protein sequence ID" value="AYE34442"/>
        <property type="gene ID" value="CP523_08375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59845">
        <property type="protein sequence ID" value="QAS59845"/>
        <property type="gene ID" value="EI377_03120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07939">
        <property type="entry name" value="DRE_TIM_NifV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013477">
        <property type="entry name" value="NifV/FrbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02660">
        <property type="entry name" value="nifV_homocitr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="387" mass="43070" checksum="D2A937958E191E97" modified="2018-12-05" version="1">MAIKNLNNGKELYIVDTTLRDGEQTAGVVFANEEKVAIASMLGELGVDQLEVGIPAMGGDEKEAIKQIVKRNKKTSIMAWNRAVIKDIEQSIDCGVDAVAISISVSDIHIKNKLRTSREWVLENMAKAVDFAKRNGLYVSVNGEDASRADVEFLIKFIKEAKIVGADRFRYCDTVGIMEPFKIKKDINYLYESTGFDIEMHTHNDFGMATANAIAGIEGGASHVGVTVNGLGERAGNAALEEVLMALMFVHNYKGNIDTTMFREVSEYVSRASGRILPSWKAIVGDNMFVHESGIHADGAIKNPKNYEAFDPDIVGLERQIVIGKHSGRAGIVNKFKEYGIELDDDSSKFILQMVRSTSIRLKRSLFDKELVQLYKEYQRVQKEKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIJ8</accession>
    <name>A0A386PIJ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_12625</name>
        <name evidence="2" type="ORF">EI377_07530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675227.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01986"/>
    <dbReference type="EnsemblBacteria" id="AYE35197">
        <property type="protein sequence ID" value="AYE35197"/>
        <property type="gene ID" value="CP523_12625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60600">
        <property type="protein sequence ID" value="QAS60600"/>
        <property type="gene ID" value="EI377_07530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010235">
        <property type="entry name" value="HepT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08780">
        <property type="entry name" value="NTase_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01987">
        <property type="entry name" value="HI0074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="145" mass="17171" checksum="138AF7A0EBCF601D" modified="2018-12-05" version="1">MSGILDKYDESINLTYNYTYRMLIHLKNIKEKYINLNKADDITLEVYRDSIIKKYETLEELTWKLLCKIFKADGLEINSPRGCYKQAFKEGLIEDMIVWNNILLARNSTAHIYDETDYEAIKNDILNNYMDAIENLLKKISTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL3</accession>
    <name>A0A386PIL3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10005</name>
        <name evidence="4" type="ORF">EI377_04790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676557.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00330"/>
    <dbReference type="EnsemblBacteria" id="AYE34708">
        <property type="protein sequence ID" value="AYE34708"/>
        <property type="gene ID" value="CP523_10005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60109">
        <property type="protein sequence ID" value="QAS60109"/>
        <property type="gene ID" value="EI377_04790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="187"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="374" mass="42551" checksum="067A1D0EC7896138" modified="2018-12-05" version="1">MKISIDARGINMYNGTGIGTYTENIVKELLNIDKTNEYTLFWTGKNYTKYKEDNTNLVFASRKHGRFYENFYFPNYIKENNIDLHHIPQNGIGMTNEYKTNCIVTIHDLIPYLMPETVGKGYLQRFLRDMPNIINQAKGIITVSEYSKKDILRFFNGFPADKIFVTPLAANSSFKPLDKLSCKKYIKETFNINNPYILYIGGFSTRKNVKELILAFNKIKKDLKIPHTLLLGGAVKDEGQKLVKLVQELNIEDSVIFTGFINSEDLPILYNAAEAFVYPSLYEGFGLPPLEAMSCKTAVITSNLTSIPEVTSNTASLINPFDKDELAKSLVNILNNEELKNSLALKGYKRSLQFSWRHTASNTLKAYESIFNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR0</accession>
    <name>A0A386PIR0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_15475</name>
        <name evidence="7" type="ORF">EI377_10185</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678721.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00186"/>
    <dbReference type="EnsemblBacteria" id="AYE35720">
        <property type="protein sequence ID" value="AYE35720"/>
        <property type="gene ID" value="CP523_15475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61060">
        <property type="protein sequence ID" value="QAS61060"/>
        <property type="gene ID" value="EI377_10185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039369">
        <property type="entry name" value="LacA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43017">
        <property type="entry name" value="PTHR43017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mac" evidence="5">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="183" mass="19999" checksum="43A2E2CBFD452EFC" modified="2018-12-05" version="1">MKGKTEKEKMLSGELYCAEDTELKKEHIKAQKILSEFNNSLSEDRSNLLKSLFGKTGNNFCIKPTFHCDYGYNIYVGENFFANYDCIILDVCKVTIGDNCMMAPRVCIYTATHPLDSEIRISGLEYGKPITIGDNVWIGGNSVITPGVTIGNNVVVAAGSVVVKNIPDNVVVGGNPAKIIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIR1</accession>
    <name>A0A386PIR1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11565</name>
        <name evidence="4" type="ORF">EI377_06380</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673340.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02871"/>
    <dbReference type="EnsemblBacteria" id="AYE35001">
        <property type="protein sequence ID" value="AYE35001"/>
        <property type="gene ID" value="CP523_11565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60394">
        <property type="protein sequence ID" value="QAS60394"/>
        <property type="gene ID" value="EI377_06380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="58"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="176" mass="19855" checksum="9D124A42F30A0743" modified="2018-12-05" version="1">MLELIQSIDINILNVIRENLTNPYMDKFMILISSLGNLGAIWIVLGILLICIKKYRKVGVILLVSLIITSIIGEGIIKNIVQRQRPFLLCPNINLIIKAPISYSFPSGHTASSFVAAFVLGNYFKDKRYIFLIFAALMGFSRMYLFVHYPSDVVAGIILGFIGYKLTNIFSEKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS4</accession>
    <name>A0A386PIS4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="8 10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adk</name>
        <name evidence="12" type="ORF">CP523_09080</name>
        <name evidence="13" type="ORF">EI377_03825</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="8 10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678373.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00255"/>
    <dbReference type="EnsemblBacteria" id="AYE34562">
        <property type="protein sequence ID" value="AYE34562"/>
        <property type="gene ID" value="CP523_09080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59962">
        <property type="protein sequence ID" value="QAS59962"/>
        <property type="gene ID" value="EI377_03825"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09080"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="11">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="8">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="8">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
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        <location>
            <position position="133"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="23997" checksum="DA276819E519DC03" modified="2018-12-05" version="1">MKIVLLGPPGAGKGTQAKSISNRYSIPHISTGDIFRKNISENTPLGVEAKKHIDKGQLVPDEITINMVKNRLQDEDCKGGYLLDGFPRTVAQAEALQQFLIERNENIDTALLIEVPMEFILERMTGRRVCPSCGASYHIKFNPPTIAGKCDVCGSDIIQRKDDSEETVSERLDVYERQTQPLIDFYKERNLLSIVDGTKAINEVFEGICDILGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT1</accession>
    <name>A0A386PIT1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail tape measure protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01951"/>
    <dbReference type="EnsemblBacteria" id="AYE35317">
        <property type="protein sequence ID" value="AYE35317"/>
        <property type="gene ID" value="CP523_13270"/>
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    <dbReference type="Proteomes" id="UP000280586">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="109" mass="10982" checksum="35F677772AD41A52" modified="2018-12-05" version="1">MADGRIVIDTDLDSKGIENGLSKMSSIAKTGSKSIIASIGGAASVIAGIGIVATKVGMDFEAGMSKVQAISGATAEDMVLLGNKAKEMGSKTKFSATESSEALSYMAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT8</accession>
    <name>A0A386PIT8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fumarate hydratase</fullName>
            <ecNumber evidence="8">4.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_09180</name>
        <name evidence="9" type="ORF">EI377_03925</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
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    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678345.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03062"/>
    <dbReference type="EnsemblBacteria" id="AYE34582">
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        <property type="gene ID" value="EI377_03925"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
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        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="280" mass="30930" checksum="F8E9FBA8B3864872" modified="2018-12-05" version="1">MREISVNEIVNSVKKLCIESNYYLSNDIKRELEKAESEEKWPIAKDILEKIILNSNIANENDIPICQDTGMACVFIEIGQDVHIIGGSLEEAINEGVRKGYEEGFLRKSVVKDPINRVNTKDNTPAVIYYNIVQGNNIKITVSPKGFGSENMSQIKMLKPSDGLDGVKEFILRVVKEAGANSCPPMVIGVGIGGTFDKAAYLAKKALLRPICIRNKDKFYKELEEELVYKINKLGIGPQGFGGKTTALGLNIETFPTHIAGLPVAVNINCHATRHKEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ6</accession>
    <name>A0A386PIZ6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmJ</name>
        <name evidence="7" type="ORF">CP523_09100</name>
        <name evidence="8" type="ORF">EI377_03845</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003448032.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34566">
        <property type="protein sequence ID" value="AYE34566"/>
        <property type="gene ID" value="CP523_09100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59966">
        <property type="protein sequence ID" value="QAS59966"/>
        <property type="gene ID" value="EI377_03845"/>
    </dbReference>
    <dbReference type="GeneID" id="66570365"/>
    <dbReference type="KEGG" id="csep:CP523_09100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="37" mass="4347" checksum="5889A9E071592038" modified="2018-12-05" version="1">MKVRPSVKPICEKCKIIRRKGRVMVICENPKHKQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ08</accession>
    <name>A0A386PJ08_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10975</name>
        <name evidence="3" type="ORF">EI377_05770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677664.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02529"/>
    <dbReference type="EnsemblBacteria" id="AYE34888">
        <property type="protein sequence ID" value="AYE34888"/>
        <property type="gene ID" value="CP523_10975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60283">
        <property type="protein sequence ID" value="QAS60283"/>
        <property type="gene ID" value="EI377_05770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="304" mass="35470" checksum="C1493532625DE04D" modified="2018-12-05" version="1">MKELAIILLNYNNVEDTLECVESIEKNCESDYTIIVVDNNSTNDSKDILIKNKKRYKLILNPVNEGFAQGNNVGIKWAIDNNFKYIMLLNNDTLIEKGSIELLLNEMNSNPNIGIIGPRIMYYPEKNKIWFDGGEIDWFKFIVNHNNIGKKISTQNSDKIKENVSFLTGCCMLINRNLIEQIGYLPEEYFMYYEDVDYCVMVKDAGYNLINLKESIIYHKVSSSSGGEDSAFSIKWGTRNRIIFMNKYKYKVDKTRYIASVLFFYSTRIIKLIKYIFKKDKERYSAIIEGIKEGKKYIEGVRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE2</accession>
    <name>A0A386PJE2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679058.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01957"/>
    <dbReference type="EnsemblBacteria" id="AYE35311">
        <property type="protein sequence ID" value="AYE35311"/>
        <property type="gene ID" value="CP523_13235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021080">
        <property type="entry name" value="Minor_capsid_protein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11114">
        <property type="entry name" value="Minor_capsid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="119" mass="13590" checksum="A7C6E1100B1D2CF4" modified="2018-12-05" version="1">MDAKVILKINDAKKILLKRYLNKNGKAQIKFTQEVAKQCNNYIPYRTGRLKDMMIKLQANKIIYNAPYARKQYYSNSGNGKQGSSLGGLRGKLWDRRMFADRGDKIVQAIAEFVGGRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJH8</accession>
    <name>A0A386PJH8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Murein L,D-transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_13450</name>
        <name evidence="5" type="ORF">EI377_08345</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00787"/>
    <dbReference type="EnsemblBacteria" id="AYE35351">
        <property type="protein sequence ID" value="AYE35351"/>
        <property type="gene ID" value="CP523_13450"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60742">
        <property type="protein sequence ID" value="QAS60742"/>
        <property type="gene ID" value="EI377_08345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13450"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="172" mass="20000" checksum="E71D4FA9125E5AF1" modified="2018-12-05" version="1">MKYILKTPLRKIYRNISYKTNSIIRTFKEDPNYIETATRFINNNNFSSSTYYFIWVDTKNFKTNIFEGSKNNWKLVKSYLCSIGKPSTPTIKGNFVVGIKGLYFGVNHGYKCWYYTQINGNYLFHSIIYNLDGSIRDGRLGVAISDGCVRLAKENAKWIYDNIPRTTAIYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJI7</accession>
    <name>A0A386PJI7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, M28 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01424"/>
    <dbReference type="EnsemblBacteria" id="AYE34776">
        <property type="protein sequence ID" value="AYE34776"/>
        <property type="gene ID" value="CP523_10380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M28" evidence="2">
        <location>
            <begin position="214"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="448" mass="50453" checksum="1D988E312B97CE10" modified="2018-12-05" version="1">MKKKVSYYLLILFITTALGFSIFFNITYSQFNSNNVKKNIANFSSQTYSGRLPGSDENNLVAEIIRKNFQDNKLTPLNDNYRENFNTVCPVKTNTQPYMQISTKGIVLEELKYGVDFKDDMINFKKNTITFSRADTVNIYTKSIDVITSDAKCLFYVNCKEDFSFRSSFSSDFPYDMVISVNTNTYNKILDSVRKGLEISVHVPFENKEKTISNVVGVLKGSSHKLPPLVLTAHYDHLGKDGLENLYSGALDNASGTSFLLELQRSLSTYGKPKRDIIFVALNAEEFGLLGSKEFAEKNIDKLHDAEVINFDMIGSEGYPLTFMQGLSFKDKDSKLLKSVEKIAKNKGVKTEVVYQDSSDHASFNNAGIDSLSFCHSDVSRIHTPNDTAEFISTNAIDTAYEVVEAKILGSSYGFLTRFFYSKISIILFSILLIVWIAYGVKKRKVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJU7</accession>
    <name>A0A386PJU7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation inhibitor MinC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Septum formation initiator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08570</name>
        <name evidence="3" type="ORF">EI377_03320</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674886.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01655"/>
    <dbReference type="EnsemblBacteria" id="AYE34479">
        <property type="protein sequence ID" value="AYE34479"/>
        <property type="gene ID" value="CP523_08570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59881">
        <property type="protein sequence ID" value="QAS59881"/>
        <property type="gene ID" value="EI377_03320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08570"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="10984" checksum="56994C1E952212B3" modified="2018-12-05" version="1">MKKRLTLKNLIIILLFAVFIFSYIRQEITMNRIRKDIETSQQKLEELKDKNSELEVKLRKAESENEYLEKLARERLGMVKDGEKVVNSQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJW7</accession>
    <name>A0A386PJW7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14425</name>
        <name evidence="2" type="ORF">EI377_09400</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676817.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35531">
        <property type="protein sequence ID" value="AYE35531"/>
        <property type="gene ID" value="CP523_14425"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60918">
        <property type="protein sequence ID" value="QAS60918"/>
        <property type="gene ID" value="EI377_09400"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14425"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="143" mass="16843" checksum="E3874CAEC92ED830" modified="2018-12-05" version="1">MNNLNAALNLNLNNISIMDINEENLILLKSEDYYIQSNFYFWLINTINELEEINKIEELAYANYLMSYFVFIILTPLCYEEIAFNHIKKSIKLSKKIKFKEWLLIFSTTSKPFLSTYDSIKIAEEVLSENPNSTLAKTIIEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK48</accession>
    <name>A0A386PK48_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIVB peptidase</fullName>
            <ecNumber evidence="4">3.4.21.116</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoIVB</name>
        <name evidence="3" type="ORF">CP523_15105</name>
        <name evidence="4" type="ORF">EI377_10060</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.116" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676004.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01263"/>
    <dbReference type="EnsemblBacteria" id="AYE35654">
        <property type="protein sequence ID" value="AYE35654"/>
        <property type="gene ID" value="CP523_15105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61041">
        <property type="protein sequence ID" value="QAS61041"/>
        <property type="gene ID" value="EI377_10060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014219">
        <property type="entry name" value="Pept_S55_SpoIVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008763">
        <property type="entry name" value="Peptidase_S55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05580">
        <property type="entry name" value="Peptidase_S55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02860">
        <property type="entry name" value="spore_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51494">
        <property type="entry name" value="SPOIVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S55" evidence="2">
        <location>
            <begin position="164"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="396" mass="43157" checksum="623BE5F32F2CBE7D" modified="2018-12-05" version="1">MTGKKIKYLSIIITPILILGLVTFFSIKKMPEKIYVNEEVSVDNISIPKTSVLNTLKYSQDDLKVEFLGIIPLKTIPVFKVNDLEVYPGGTSVGVRLSTKGVLVVGHSEIETSEGRAESPAKNSGIELGDILTKVNGETIESSKDLARKIKENTEPVINVELIRNNEAESKEVQLLKEGEEFKLGLWVRDSTAGIGTLTFFDKESSTFGALGHPITDGDTNKPFTIKKGELLPASVISVRKGEKGSPGELKGLFTSNKDNIGSIEKNTQSGIFGTTIEPFVNPLYSKPLKVGFRNEIKEGPAKIITTLDENGPKEYDIEIVKLLSQDEAGPKSMVIKVTDEELLEKTGGIVQGMSGSPIIQNNKIIGAVTHVLINKPDVGYGIYIEWMLQDAGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKA6</accession>
    <name>A0A386PKA6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="9" type="ORF">CP523_09660</name>
        <name evidence="10" type="ORF">EI377_04440</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676710.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02638"/>
    <dbReference type="EnsemblBacteria" id="AYE34669">
        <property type="protein sequence ID" value="AYE34669"/>
        <property type="gene ID" value="CP523_09660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60069">
        <property type="protein sequence ID" value="QAS60069"/>
        <property type="gene ID" value="EI377_04440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09660"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="450" mass="50147" checksum="3891C791B324E3A0" modified="2018-12-05" version="1">MNKSLRLDLSKVEPYVKQHELDYMETMVNGAHKVLHEKTGAGNDFLGWLDLPVNYDKDEFERIKAAAERIKKNSEALIVIGIGGSYLGPRAAIEMLNSNFYNVLGNDKRKAPRVFFVGNNISSTYLAELLEAIDGMDISVNVISKSGTTTEPAIAFRVFKEYMENKYGVDGAKERIFATTDRSRGALKSLSNEMGYETFVIPDDVGGRFSVLTAVGLLPIAVAGISIDDMMQGAADAREAYATCDLKNNDCYKYAAMRNALYNKGKSVEILVNYEPGLHYFNEWWKQLYGESEGKDNKGIFPAAVDFSTDLHSMGQFIQEGSRIMFETVLNVEKVRKEMTIEKAEGDLDGLNFLSGKTIDFVNKQAFNGTLLAHNDGGVPNMVLNIPEMSPYYFGYMVYFFEKACAISGYMLGVNPFDQPGVEAYKKNMFALLGKPGYEDLKAELEAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKF9</accession>
    <name>A0A386PKF9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2975 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12755</name>
        <name evidence="3" type="ORF">EI377_07630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678178.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02788"/>
    <dbReference type="EnsemblBacteria" id="AYE35222">
        <property type="protein sequence ID" value="AYE35222"/>
        <property type="gene ID" value="CP523_12755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60617">
        <property type="protein sequence ID" value="QAS60617"/>
        <property type="gene ID" value="EI377_07630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021354">
        <property type="entry name" value="DUF2975"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11188">
        <property type="entry name" value="DUF2975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="164" mass="18916" checksum="9008529379219387" modified="2018-12-05" version="1">MKFYGEKSLSQILKITLNIAIIFGIVMTGDVFYNTFFNREKSLNTNEKVVFVTLLIIGIISLFLIVLELRKIIGTLIESNPFVRENVVSFKKISVESFIIAGCYITNLIFNSNFKNFKFIYVDNSGIHTDMEFLIFLFAGIFIFILAKVFEKAVEFKEENDFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKJ8</accession>
    <name>A0A386PKJ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS glucose transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CP523_10455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01409"/>
    <dbReference type="EnsemblBacteria" id="AYE34789">
        <property type="protein sequence ID" value="AYE34789"/>
        <property type="gene ID" value="CP523_10455"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
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            <dbReference type="PROSITE" id="PS51103"/>
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        <source>
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    </evidence>
    <sequence length="562" mass="59599" checksum="9A25586652A5AEF6" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKU8</accession>
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            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000288332"/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
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                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <location>
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            <begin position="67"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
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                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35894">
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        <property type="gene ID" value="CP523_15265"/>
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        <property type="component" value="Chromosome"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="110" mass="12895" checksum="4ECA8D29ABE6662C" modified="2018-12-05" version="1">MYLEGFNSSEISRLLNNKGIKVTKAAIQKYIQRNLKNLKYIHERKVIERREIIKATNYEAKRHMTDKAFIMKNRSIYKTKANGDIVLNKTIAPAVTWDTPRRLSNENKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL06</accession>
    <name>A0A386PL06_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00120</name>
        <name evidence="2" type="ORF">CP523_13870</name>
        <name evidence="3" type="ORF">CP523_15410</name>
        <name evidence="4" type="ORF">EI377_08765</name>
        <name evidence="5" type="ORF">EI377_10780</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AYE32966">
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        <property type="gene ID" value="CP523_00120"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35425">
        <property type="protein sequence ID" value="AYE35425"/>
        <property type="gene ID" value="CP523_13870"/>
    </dbReference>
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        <property type="gene ID" value="CP523_15410"/>
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    <dbReference type="EnsemblBacteria" id="QAS60813">
        <property type="protein sequence ID" value="QAS60813"/>
        <property type="gene ID" value="EI377_08765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61166">
        <property type="protein sequence ID" value="QAS61166"/>
        <property type="gene ID" value="EI377_10780"/>
    </dbReference>
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    <dbReference type="KEGG" id="csep:CP523_13870"/>
    <dbReference type="KEGG" id="csep:CP523_15410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="61" mass="6784" checksum="2D8DA2DDDB3ABCC0" modified="2018-12-05" version="1">MSNLTQLELQNLRHLIGAHGTIANKLDDFAKQCTDPAICNMLQQDANAARTSKDKLITFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL57</accession>
    <name>A0A386PL57_CLOSE</name>
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        <submittedName>
            <fullName evidence="11">ABC transporter ATP-binding protein/permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Cysteine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_12055</name>
        <name evidence="11" type="ORF">EI377_06880</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02968"/>
    <dbReference type="EnsemblBacteria" id="AYE35089">
        <property type="protein sequence ID" value="AYE35089"/>
        <property type="gene ID" value="CP523_12055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60482">
        <property type="protein sequence ID" value="QAS60482"/>
        <property type="gene ID" value="EI377_06880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="354"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="599" mass="67302" checksum="E92BABF6EFA306DE" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLI1</accession>
    <name>A0A386PLI1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_13120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677865.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02565"/>
    <dbReference type="EnsemblBacteria" id="AYE35289">
        <property type="protein sequence ID" value="AYE35289"/>
        <property type="gene ID" value="CP523_13120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13120"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
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    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="178"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="864" mass="99820" checksum="9DFC76468244B744" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLK5</accession>
    <name>A0A386PLK5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_15795</name>
        <name evidence="10" type="ORF">EI377_10500</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678930.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00118"/>
    <dbReference type="EnsemblBacteria" id="AYE35782">
        <property type="protein sequence ID" value="AYE35782"/>
        <property type="gene ID" value="CP523_15795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61118">
        <property type="protein sequence ID" value="QAS61118"/>
        <property type="gene ID" value="EI377_10500"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="5"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="388" mass="42727" checksum="78BFA596D1AACB69" modified="2018-12-05" version="1">MKEKSIRSLLILTIFISIALSMAHPVTPALIRELGLPSFMFGVFFATMSFGNFVFSPIWGGLSDKKGRVKYLIIGLLGYGISQIGFGFSNNSVVIVVFRLLGGAFITGYLTVSIAYLTDITTKENRLKIMAYYAACNTVGNALGSLLGGVIGNTNYKLTFLTQSIICIILSGVIYFMLSETITNNGEKVVIKLNSFRFSNKNEKLNKNLVLILLMVVIFYFSSTSYSSSINYYIESILRLPPSFNGAFLSIAGICGFLGNLILTPYIGKKLDDTISFKYLTIFLGITLLLAAVTKNTGLFFVWIIIFVTIGSIYVPIQQNIITRLTKENYGSLMGLQNSAKSMGMVLGSLFAGFIFDFGSKLPFLIASFVLIIGYIILTKFKLEVIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLR7</accession>
    <name>A0A386PLR7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_13940</name>
        <name evidence="10" type="ORF">EI377_08830</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678809.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00155"/>
    <dbReference type="EnsemblBacteria" id="AYE35439">
        <property type="protein sequence ID" value="AYE35439"/>
        <property type="gene ID" value="CP523_13940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60826">
        <property type="protein sequence ID" value="QAS60826"/>
        <property type="gene ID" value="EI377_08830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="7">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="8">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="141" mass="16266" checksum="25799F8DD5370147" modified="2018-12-05" version="1">MFQITSIKNGLVIDHIKAGKGIKIFNYLNLENEKNQVTLIINADSKILGKKDIIKIENIREINYTVLSILSPSITINEVRNGEINKKFKPKLPTRVLNILKCNNPRCITVDEKYVNHSFKLVNLKECTYRCEYCDNITKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLT5</accession>
    <name>A0A386PLT5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35776">
        <property type="protein sequence ID" value="AYE35776"/>
        <property type="gene ID" value="CP523_15765"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15765"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045407">
        <property type="entry name" value="DUF6512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20122">
        <property type="entry name" value="DUF6512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="171" mass="20384" checksum="72C702973926654D" modified="2018-12-05" version="1">MDRLITICVIFSFILGTLLHFTYEIFNRNKFIGYFSATNESIWEHIKLSIFPIFIFMIILISFNYKNINNPFFALGISLLFSLIIVPTLFYSYTYFTKKSIFLIDILIFVIAVVLPFLLIKYIINLPKFFIIFELIGILLTVSILFMFFYFTYHPPKHKIFIPFNYLKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PB97</accession>
    <name>A0A386PB97_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ORF">CP523_01335</name>
        <name evidence="4" type="ORF">EI377_11835</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675570.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00818"/>
    <dbReference type="EnsemblBacteria" id="AYE33195">
        <property type="protein sequence ID" value="AYE33195"/>
        <property type="gene ID" value="CP523_01335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61365">
        <property type="protein sequence ID" value="QAS61365"/>
        <property type="gene ID" value="EI377_11835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="99" mass="11252" checksum="AD5E4BD67273C931" modified="2018-12-05" version="1">METNIGIKEKSKVKIKKPKNFKVIMHNDDFTTMEFVVAILMDIFNKDINEANKVMLDVHKSGRGIAGIYPYDIALSKVSKAMSLAREEGFPFNLTVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBC7</accession>
    <name>A0A386PBC7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF378 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00580</name>
        <name evidence="3" type="ORF">EI377_11070</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33050">
        <property type="protein sequence ID" value="AYE33050"/>
        <property type="gene ID" value="CP523_00580"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61219">
        <property type="protein sequence ID" value="QAS61219"/>
        <property type="gene ID" value="EI377_11070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="72" mass="7960" checksum="1DAB5244273947BC" modified="2018-12-05" version="1">MCKITLLDKISFILVLISAITWGIIGIFNVNIIALLSGNSVLIQRIIYILVFAAAINLIKVVFKCKALEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBH5</accession>
    <name>A0A386PBH5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">purD</name>
        <name evidence="10" type="ORF">CP523_01760</name>
        <name evidence="11" type="ORF">EI377_12280</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677330.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02399"/>
    <dbReference type="EnsemblBacteria" id="AYE33275">
        <property type="protein sequence ID" value="AYE33275"/>
        <property type="gene ID" value="CP523_01760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61446">
        <property type="protein sequence ID" value="QAS61446"/>
        <property type="gene ID" value="EI377_12280"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01760"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="415" mass="45739" checksum="67E023791A6748C4" modified="2018-12-05" version="1">MKLLLIGSGGREHAIAWKLAKNEKVSKIFVSPGNGGTAILDKCENIDITDIDELVVFAKGNNIDLTVVGPEEPLTKGIVDLFKEEGLKIFGPDKRGAELEGSKSYSKDFMKKYGVKTAEYEVFYNSDKALSYLENCEYPIVIKADGLAAGKGVSICETREEAKSTIKSFMIDDIFSGAGNKVVIEEFLEGVEASILSITDGKTIIPFLSAKDHKQIFNEGKGPNTGGMGVLAPNPYVTDKVQKDFEENIMNKTLEGIKKEGFDFKGIIFFGLMITKKGTYLLEYNVRMGDPETQSVLYLMESDLLELIEAALDEKLENKEVLWNNGTCINVVLASKGYPGAFKKGYEINIKEEIKDKVFLAGAKLENGVLKTNGGRVLSVIGTGETIEEARKEAYKNIESVNFTDKYYRDDIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBP8</accession>
    <name>A0A386PBP8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02235</name>
        <name evidence="4" type="ORF">EI377_12755</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674028.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00520"/>
    <dbReference type="EnsemblBacteria" id="AYE33363">
        <property type="protein sequence ID" value="AYE33363"/>
        <property type="gene ID" value="CP523_02235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61533">
        <property type="protein sequence ID" value="QAS61533"/>
        <property type="gene ID" value="EI377_12755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="97"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="113" mass="12848" checksum="759C7880876B4FDC" modified="2018-12-05" version="1">MNCIFCKIINGEIPTEKIYEDEKVVAFNDINKEAPIHFLVIPKVHIQSVNEINKDNSDIISHIFMVINKIVKELGIDKSGYRIVNNCGNDGGQTVNHIHFHVLGQRELKWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBT0</accession>
    <name>A0A386PBT0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01415</name>
        <name evidence="2" type="ORF">EI377_11935</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675597.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33210">
        <property type="protein sequence ID" value="AYE33210"/>
        <property type="gene ID" value="CP523_01415"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61382">
        <property type="protein sequence ID" value="QAS61382"/>
        <property type="gene ID" value="EI377_11935"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01415"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="24365" checksum="11D04B64ECC1001C" modified="2018-12-05" version="1">MSLFLGKIHYWLFNKIVWFEGLEKEIIDLAKKEGIDIEKLSNVINGEFGESLPNLPLENIIDKNNIHGWLQERIHSAEGRIATWTKEILKNGDNFSKLENVYITQGMKAAKEALEKGVEAGTAIDIFNSMNDYILDGMPCDRVNEILISEENEVKWIRRVCVHKDIWEKAGVEVKNFYILRGLWVKAFVTELNSNFQYVENEDGSMEIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBT4</accession>
    <name>A0A386PBT4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02465</name>
        <name evidence="2" type="ORF">EI377_13000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673956.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33403">
        <property type="protein sequence ID" value="AYE33403"/>
        <property type="gene ID" value="CP523_02465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61577">
        <property type="protein sequence ID" value="QAS61577"/>
        <property type="gene ID" value="EI377_13000"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="130" mass="14745" checksum="022F261A1073383B" modified="2018-12-05" version="1">MKKSLLFLSLLTILILVCFHFNFFKLIDTKTNIVRTISKNKIHKVTFESLSKLTTKNKRDVIEVDILVKDIDTENLIITSEGPTEEVTIQFQSDEDLSKIKSGDKIKIRAIKKGINSSPNIVTLDNAIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBV0</accession>
    <name>A0A386PBV0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AI-2E family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00593"/>
    <dbReference type="EnsemblBacteria" id="AYE33017">
        <property type="protein sequence ID" value="AYE33017"/>
        <property type="gene ID" value="CP523_00410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="388" mass="43570" checksum="006762C228402D38" modified="2018-12-05" version="1">MLEKLKLESKYIRYGLYIILAILLLFLGYKIIDNGSYLIDITKSNIYNFFRMISPIFYAFLISYLLFKPVVFFQNLISKLYSSITKRKINDRIYKISRVLGIIIMFVIISISIALVINFVIPPIVENIKILLSKLPEYQTQMKIWIEEIVGFFNKNNMDIQATGELATGVTDKLFLVGNKTLAFIANSVTTLSSLILDLILTIILTFYFLKDKEVLFKNFKKIRDVVMPKKFGRALTIFVNDIDEIVGKFLVAEILDSVIVGVVSTILMLLIRHPFYILIGCVAGLTNIIPYVGPIIGAALAFGLGIFSSLGLGVSGAILLLLYQQIDGNFVQPKIVGDKVGLIPVWILIAVLIGGSYFGAIGMILSIPVAGLIRIYFNRYAKYKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBX1</accession>
    <name>A0A386PBX1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02670</name>
        <name evidence="9" type="ORF">EI377_13195</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676942.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00940"/>
    <dbReference type="EnsemblBacteria" id="AYE33443">
        <property type="protein sequence ID" value="AYE33443"/>
        <property type="gene ID" value="CP523_02670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61614">
        <property type="protein sequence ID" value="QAS61614"/>
        <property type="gene ID" value="EI377_13195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02670"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="229"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="437"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="493" mass="55919" checksum="36D4982924F0DB17" modified="2018-12-05" version="1">MRITGLATGMDIDSIVKDSMKPYRIKIDKVKQDKDRISFKQEMYRDLVKESREFYNKYFDLQSEDNLIMTKNYETVKFTSKDDVIATARGEAGAKAGNYTVTVDELAEPSKIVKTVDELNGKKEIKFKYRNKEVKVNIDGLTDKKEIARKLNAEASSIGLKVEYSDFAKGFVFETRDTGKLIEGEENKFELTIDSGVAEKSDGEKNAKVTIENSRGEKVEYSDSKEVLASNKVKIDGIEFSFNKVGKTDISGKVDVTDAKKKIVSFVKDYNKLMENLNKLTNQTKAKGYNPLTEDQKKEMSKEEIELWNKKVKQGLLYRDNDVTRLVNNLKNAMSSVVNGSSIALKDIGLTPVKDFKDKNGTFTLDENKLTKALEENSDLVMDLFLKSPKENDTNEKKFQNSGIFQRLKTVLYDETVTVTAPIIKKAGVEGSVTVVNNELTKMLQKKDRKIEDMEKDFTRREQQLYTKYSKLETAMNKLNAQQASLSQQLGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC23</accession>
    <name>A0A386PC23_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_02940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33493">
        <property type="protein sequence ID" value="AYE33493"/>
        <property type="gene ID" value="CP523_02940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="406" mass="46739" checksum="0D1A2AC702F01DB6" modified="2018-12-05" version="1">MSFSKKELIKILAKDPNIKTAEDIQNVLKDLFGGMLQQMLEAELDNHLGYEKHDYQNKNTTNSRNGKSRKTMKSNLGYFDLDVPRDREGSFEPEIVKKHQTDVSHLESSIIGMYAKGMTTRDIASQVNEIYGMDISPTLVSNITDKVITMIREWQSRPLETVYPIVFMDAIHFKVRKDNTVVSKAAYAAIGVNIEGKKDVLGIWIGASESSKYWLLVLNELKNRGVKDILIASVDGLVGFNEAIRAVYPNTEIQRCIIHQIRNSSKYLSYKDLKAFNADLKLVYTASTEEVALAELDRLEEKWGEKYLIAVRSWRNNWNELSTFFKYPPEIRKIIYTTNAMESYNRQLRKVTKTKSIFPNDESLMKILYLATVDITKKWTQSIRGWAQILAQLSIFFEGRLDDQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC36</accession>
    <name>A0A386PC36_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF4250 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03005</name>
        <name evidence="2" type="ORF">EI377_13505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678445.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33505">
        <property type="protein sequence ID" value="AYE33505"/>
        <property type="gene ID" value="CP523_03005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61671">
        <property type="protein sequence ID" value="QAS61671"/>
        <property type="gene ID" value="EI377_13505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025346">
        <property type="entry name" value="DUF4250"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14056">
        <property type="entry name" value="DUF4250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="62" mass="7208" checksum="7320C987DFB5D2F3" modified="2018-12-05" version="1">MDRESILSMDPNILVSMVNMKLRDLYSSLEAFCEDIGIESKELEDKLSAVGYNYEKKQNQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC85</accession>
    <name>A0A386PC85_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunit delta</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">holA</name>
        <name evidence="2" type="ORF">CP523_02325</name>
        <name evidence="3" type="ORF">EI377_12845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673995.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00502"/>
    <dbReference type="EnsemblBacteria" id="AYE33380">
        <property type="protein sequence ID" value="AYE33380"/>
        <property type="gene ID" value="CP523_02325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61550">
        <property type="protein sequence ID" value="QAS61550"/>
        <property type="gene ID" value="EI377_12845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02325"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="343" mass="40227" checksum="21D368C21346156F" modified="2018-12-05" version="1">MINLDGLENEVKKGQVDNSYIFCGLDEELIKEGIEKIVNKVLDKNFLDLNYIRLDGMITTIDEIINACETMPFLGEKKVVVIYRANFLKEKSDSSNSKTYKEVSAYLKDLPSHTILIMYYLFSDKRDTPKKNKKLSTLEKVSKIVYCDKLKKDRYYRKIEEVFKKSGGEIGKIELRYFAEKVQNNFDIIKREVDKLVLYTNGRAITKRDIDKLIQNKSEDDIFDLVDLISQRKAEKAIDLMDELLFKADQHMLIITNIENNFKRLYEMKILISKGKRVDELASKFRLPTFIVEKLMGQCSKFTVKQLQELMKLCLETEKRIKSSNVDKQTEMEIMLFKSFMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCF2</accession>
    <name>A0A386PCF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_01140</name>
        <name evidence="4" type="ORF">EI377_11640</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674418.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02290"/>
    <dbReference type="EnsemblBacteria" id="AYE33157">
        <property type="protein sequence ID" value="AYE33157"/>
        <property type="gene ID" value="CP523_01140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61327">
        <property type="protein sequence ID" value="QAS61327"/>
        <property type="gene ID" value="EI377_11640"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01140"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="152" mass="17714" checksum="2014B6148706D431" modified="2018-12-05" version="1">MEQMAGIDFNLLKEELKQKGYKLTPQRRAIVDSIIENEGEHLTAEEIYDEVKKNCPEIGLATVYRTIILLEELGVICKLDLNDGCSRYELVHKDETHRHHHLVCNECKNVLEVQDDLLDELEEEIERSYGFKILDHSVKFFGICKKCQSKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCI2</accession>
    <name>A0A386PCI2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_02925</name>
        <name evidence="6" type="ORF">EI377_13450</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677021.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00991"/>
    <dbReference type="EnsemblBacteria" id="AYE33490">
        <property type="protein sequence ID" value="AYE33490"/>
        <property type="gene ID" value="CP523_02925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61661">
        <property type="protein sequence ID" value="QAS61661"/>
        <property type="gene ID" value="EI377_13450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="229" mass="25897" checksum="AFFA66A686536548" modified="2018-12-05" version="1">MIELNNISKIYNTGKIQYEALKNISLNIEKGEFTAIMGPSGSGKSTLMNILGCLDRYNSGKYKLNNRLINDLTDDELAKIRNIEIGFVFQNFNLLPRLNILENVELPMIYAGVSVKERNKRAISALEKVGLLPWIKHRPNEISGGQRQRVAIARAIVNNPSVIMADEPTGNLDSKVSLEVMKIFQNLNKEGTTIIMVTHEEEIARYTKRVVYVKDGEIFKDENIICKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCK4</accession>
    <name>A0A386PCK4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitermination protein NusB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF1905 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03030</name>
        <name evidence="2" type="ORF">EI377_13530</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678436.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33510">
        <property type="protein sequence ID" value="AYE33510"/>
        <property type="gene ID" value="CP523_03030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61676">
        <property type="protein sequence ID" value="QAS61676"/>
        <property type="gene ID" value="EI377_13530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03030"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037079">
        <property type="entry name" value="AF2212/PG0164-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015018">
        <property type="entry name" value="DUF1905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08922">
        <property type="entry name" value="DUF1905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="153" mass="17514" checksum="44A187275CDCBBC0" modified="2018-12-05" version="1">MEKFNGELKMAQGKGGAYIEIPFNVENVFGAKRVKVKVTFDGVEYRGSIVKMGGGCHIIGVTKEIRGKINKDFGDMVLVTVEKDEEERVVQVPEDLELELARDKEINDTWNSMSFLNRKKYVNWIVSAKREETRSNRVKESLRMLKNKKSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCM3</accession>
    <name>A0A386PCM3_CLOSE</name>
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        <submittedName>
            <fullName evidence="6">Rubrerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_04110</name>
        <name evidence="7" type="ORF">EI377_14630</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676887.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33713">
        <property type="protein sequence ID" value="AYE33713"/>
        <property type="gene ID" value="CP523_04110"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61868">
        <property type="protein sequence ID" value="QAS61868"/>
        <property type="gene ID" value="EI377_14630"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04110"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="180" mass="21269" checksum="C780853445F43681" modified="2018-12-05" version="1">MELKGSKTEKNLYRTFAGESRARNKYNLYAEKARKDGYQWVGEIFDTTAHNEFAHAREVYNKYLGLLGTTKENLIDAIMGETEEYKVLYKNFEIEAREEGFMDIADFYKELREVEEHHEERFKNLFDKLEDGTMFKGPEESKWICMNCGYIHEGMDAPLVCPLCKYPRAYFKPYCEITNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCN7</accession>
    <name>A0A386PCN7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_04220</name>
        <name evidence="11" type="ORF">EI377_14745</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00432"/>
    <dbReference type="EnsemblBacteria" id="AYE33733">
        <property type="protein sequence ID" value="AYE33733"/>
        <property type="gene ID" value="CP523_04220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61890">
        <property type="protein sequence ID" value="QAS61890"/>
        <property type="gene ID" value="EI377_14745"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362691" evidence="7">
        <location>
            <begin position="34"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="762"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1243"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1244"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1318" mass="147454" checksum="3D1FA8C7FD46F2FD" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCU9</accession>
    <name>A0A386PCU9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator AsnC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Winged helix-turn-helix transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_01940</name>
        <name evidence="6" type="ORF">EI377_12460</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678272.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01160"/>
    <dbReference type="EnsemblBacteria" id="AYE33307">
        <property type="protein sequence ID" value="AYE33307"/>
        <property type="gene ID" value="CP523_01940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61477">
        <property type="protein sequence ID" value="QAS61477"/>
        <property type="gene ID" value="EI377_12460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01940"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
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        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="155" mass="17521" checksum="FFBBD89DA1D55A9E" modified="2018-12-05" version="1">MGLNQTYQLDELDLQILDLLIKDCRTPYLEIARICHVSGGTIHVRMKKMEELGIIKGTRILLNLPKLGYDVCCFVGIYVDKTESFSSVFGELSQIKEVVELHLTTGNYSIFAKVICKNISDLQDILLNKINSISGIQRTDTFISLEQPIDRNISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD53</accession>
    <name>A0A386PD53_CLOSE</name>
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        <recommendedName>
            <fullName evidence="3">Inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_02485</name>
        <name evidence="11" type="ORF">EI377_13020</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673951.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00470"/>
    <dbReference type="EnsemblBacteria" id="AYE33407">
        <property type="protein sequence ID" value="AYE33407"/>
        <property type="gene ID" value="CP523_02485"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61581">
        <property type="protein sequence ID" value="QAS61581"/>
        <property type="gene ID" value="EI377_13020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02485"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="546" mass="60578" checksum="A00F91B237BE6B80" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD60</accession>
    <name>A0A386PD60_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-ascorbate 6-phosphate lactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05255</name>
        <name evidence="2" type="ORF">EI377_15815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676261.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01840"/>
    <dbReference type="EnsemblBacteria" id="AYE33925">
        <property type="protein sequence ID" value="AYE33925"/>
        <property type="gene ID" value="CP523_05255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62076">
        <property type="protein sequence ID" value="QAS62076"/>
        <property type="gene ID" value="EI377_15815"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="354" mass="40286" checksum="61AA00FB0F2DBE32" modified="2018-12-05" version="1">MSKVDEITRESWVLGTFPEWGSWLNEEIEQEVVKPNTFAMWWLGCTGIWLKSEGGANLCIDFWCGSGKRTHANPYMDPQHQMSRMCGGKKLQPNLRVAPFVLDPFRIREVDAVISTHDHNDHIDVNVAAAVLKNCDEKVPFIGPQACVDKWIGWGVPKERCIVVKPGDTIKIKDVELVALESFDRTALITSPPEGNLVGTMPINMDIKAVNYLIKTTGGNLYHSGDSHYSNYYAKHGNEHKVDVALGSFGENPRGITDKMTSSDILRMAEALNTQVIIPFHHDIWSNFQADTNEINVLFEMRKHRLQYKFVPFIWQVGGKFTFPTDKDNREYHYPRGFDDCFSKPINTPYTSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD95</accession>
    <name>A0A386PD95_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33973">
        <property type="protein sequence ID" value="AYE33973"/>
        <property type="gene ID" value="CP523_05555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="62" mass="6841" checksum="B7BD954A112A9C6F" modified="2018-12-05" version="1">MLLTLFRNKIPFAAPTTPSIGWLTNSKISFATPTSASSISNKKLIVTLFIVINSLFLFILLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDA6</accession>
    <name>A0A386PDA6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00385"/>
    <dbReference type="EnsemblBacteria" id="AYE33780">
        <property type="protein sequence ID" value="AYE33780"/>
        <property type="gene ID" value="CP523_04465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="122" mass="14600" checksum="F4F917EB9C2357A5" modified="2018-12-05" version="1">MNNKREILFHEIKKVFKSPIVLVVFAIFLGVDLFIVFKNYGFRDDLKVLNTIIDEVGYEINDKMMDNFKVYYENRFKDTMDMIKKVEGKSYSSMGEHLRAIEYNLYDVRYTKEEKRICLTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDD4</accession>
    <name>A0A386PDD4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine/serine exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_00380</name>
        <name evidence="8" type="ORF">EI377_10870</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678144.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00587"/>
    <dbReference type="EnsemblBacteria" id="AYE33011">
        <property type="protein sequence ID" value="AYE33011"/>
        <property type="gene ID" value="CP523_00380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61180">
        <property type="protein sequence ID" value="QAS61180"/>
        <property type="gene ID" value="EI377_10870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="155" mass="16696" checksum="EF4032C5A31B996E" modified="2018-12-05" version="1">MLGETLAAFVATIGFGILFNIKGKKLIFAGIDGAIGWFVYKFILILGLSQVSALFIASISISIFSEVYARVLKTPVTTFIVCALIPLVPGGGMYYTMVEAITGNIMESLETGINTLASAGSLALGIICVSTVTRIIMSYNNSKSFKFRHSRHMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDG8</accession>
    <name>A0A386PDG8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_05955</name>
        <name evidence="4" type="ORF">EI377_00435</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01893"/>
    <dbReference type="EnsemblBacteria" id="AYE34043">
        <property type="protein sequence ID" value="AYE34043"/>
        <property type="gene ID" value="CP523_05955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59415">
        <property type="protein sequence ID" value="QAS59415"/>
        <property type="gene ID" value="EI377_00435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05955"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="398"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="477" mass="52626" checksum="7DE611F83306AA09" modified="2018-12-05" version="1">MYDVAIIGAGVIGASIFRELTKYNLKAIVLEKENDVSMGTTKANSAIIHAGYDPKIGTLMAKYNVKGNEMFESLCKELDVPFKRNGSLVVAFSEEEMKTVQELYENGNKIGVKGLKILNKEELLEKEPNLSQEVVGALYAPTGGIVGPFEYTIALMENAVTNGGELMLRAEVNKIEKLKDIFKLTTKDGRIVEAKYVINASGIHADDIHNLICKEAFKIIPRKGEYFVMDKTQGSLVSSTIFQCPSKLGKGILVTPTIHGNLLVGPDAEDIDDKDDTKTEGDRLDYIRETSMKTTKKINFRESIRNFAGLRANPSTGDFIIQEAEDVKNFIDVAGIKSPGLSSAPAIAEGVVEILKNCGLTLTKNEKFNPIRKEIRFMELSAEEKADVIKKDPRYGKIICRCESITEGEIVAAIERCFGENMTLDGVKRRCRPGMGRCQGGFCGPKVQEIIARELSIKMEDINLEKDGSYILVGKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDH2</accession>
    <name>A0A386PDH2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04805</name>
        <name evidence="2" type="ORF">EI377_15315</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33840">
        <property type="protein sequence ID" value="AYE33840"/>
        <property type="gene ID" value="CP523_04805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61986">
        <property type="protein sequence ID" value="QAS61986"/>
        <property type="gene ID" value="EI377_15315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="323" mass="37583" checksum="9451106AC06A7B5B" modified="2018-12-05" version="1">MGMMNYMVSEEAIFLDERLNAEEKYFLIGLWSLDRSRVGVVEVTYKDIMDFIKIRSRSKISKLLSNLKTKGYIEMMKTGRATRYFLYKGYLFYKSLVEKTLNIGGQEFKKVKNNSEENIEDKVDVEVSKDNNITKDKVNKKVTEDKNVSKNEYDDGGINGISNMKNSNEKYSKASEIGEVLQSLNGKTSDVSMVSKVGTHNGSIDETLKIQEKNNNIYIRIIECWNSCNINGKEELSLKNKLAMEKALLNFSVYEIIDGISHYSEILKSKYYYSFVWSLKSFLVKDNGIKRFVDKGDLWNQYSLKFKNKDKFKKKMDFTKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDR8</accession>
    <name>A0A386PDR8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-6-phosphate aldolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00240</name>
        <name evidence="3" type="ORF">EI377_10645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677374.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01184"/>
    <dbReference type="EnsemblBacteria" id="AYE32988">
        <property type="protein sequence ID" value="AYE32988"/>
        <property type="gene ID" value="CP523_00240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61144">
        <property type="protein sequence ID" value="QAS61144"/>
        <property type="gene ID" value="EI377_10645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="225" mass="25096" checksum="0F8703EA497AEA20" modified="2018-12-05" version="1">MEYMFDTANIEIIKKYSDFFPITGVTSNPTILKKEGKIDFFNHFRKIREIIGFDKTLHIQVIAQDCEGILKEAKAILENVDDKVCIKIPVNLEGLKAMRILKSQGVFITATAIYTTAQGLLAMEAGADFIAPYFNRMENMGIDPGKVIKELADMMEKYNYKTKILAASFKNIGQVNESFACGAQTATMAPEILIDALKMPAIQKAVDDFSTDWESVFGKISIADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDS5</accession>
    <name>A0A386PDS5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02890</name>
        <name evidence="4" type="ORF">EI377_13415</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677010.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00984"/>
    <dbReference type="EnsemblBacteria" id="AYE33484">
        <property type="protein sequence ID" value="AYE33484"/>
        <property type="gene ID" value="CP523_02890"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61655">
        <property type="protein sequence ID" value="QAS61655"/>
        <property type="gene ID" value="EI377_13415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02890"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="15778" checksum="B47D5FA803075239" modified="2018-12-05" version="1">MEWKTFLKEKEIKVTKGRVALLNILESSDSGLSADDLYDECKRQGVNLNLSTIYRSLELFEENGVIKRIAVGNGPSIYAMKKESHEHILKCDICNRLVKIPCPIDQIEEIIKKEVGFSLTEHKLELKGICDICKNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDZ1</accession>
    <name>A0A386PDZ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_05780</name>
        <name evidence="8" type="ORF">EI377_00265</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674962.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01856"/>
    <dbReference type="EnsemblBacteria" id="AYE34010">
        <property type="protein sequence ID" value="AYE34010"/>
        <property type="gene ID" value="CP523_05780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59382">
        <property type="protein sequence ID" value="QAS59382"/>
        <property type="gene ID" value="EI377_00265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
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        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
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        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
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        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="588" mass="69263" checksum="E435D9EFDBFF2394" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE02</accession>
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        <submittedName>
            <fullName evidence="2">Cytochrome C551</fullName>
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        <name evidence="2" type="ORF">CP523_07230</name>
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        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01063"/>
    <dbReference type="EnsemblBacteria" id="AYE34255">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="zf-trcl" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="50" mass="5922" checksum="F69E86F858CBB194" modified="2018-12-05" version="1">MTDKIIICKDCGSEFVFSVGEQEFYKEKGFDNEPTRCISCRRAKKEQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>A0A386PE19_CLOSE</name>
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        <submittedName>
            <fullName evidence="4">Magnesium transporter</fullName>
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        <name evidence="4" type="ORF">CP523_04080</name>
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    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 7534</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AYE33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02770"/>
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        <property type="protein sequence ID" value="AYE33707"/>
        <property type="gene ID" value="CP523_04080"/>
    </dbReference>
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        <property type="gene ID" value="EI377_14600"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MgtE_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="293"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="358"/>
            <end position="415"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="418" mass="48434" checksum="F4C26B4D3363809F" modified="2018-12-05" version="1">MKKLSVFLYTSILGKKMYDEFDEVLGVLRDVYVTTEDGYPRIIGYRVKRDGHTFDYEFRSIYFYQSENKVKIMTRGSKEILPRTYSYLLSQNLLDKKIVDINGKQVVRVDDLRIAEIAGEYRVLAVETGPSARFRRMNCVSLGKFIYKLINKDYEDKVLMWDDVESLEMVNNNLQISVPYKKLSTLHPADLADILEDLDEGARKQVFESLDEDLAADTLEEIEPEYKGSIIKELSDSKAAELLENMPNDEIADLLDELDDEEREKILINLEREDAEEVKELLQYEDESVGSIMSKDFISFNMDITIGEIIDILREMEDPEEEELYCIYITDEEDRVLGALKLMDLILNANNVKAKEVMETNINVIRYDVEIQEAVELASKYDLLTIPVIDENEQLIGAVSTHDLIDEVLYPTWKKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE97</accession>
    <name>A0A386PE97_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion-translocating oxidoreductase complex subunit G</fullName>
            <ecNumber evidence="6">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rnf electron transport complex subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name evidence="9" type="ORF">CP523_01300</name>
        <name evidence="10" type="ORF">EI377_11800</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnfG family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00811"/>
    <dbReference type="EnsemblBacteria" id="AYE33188">
        <property type="protein sequence ID" value="AYE33188"/>
        <property type="gene ID" value="CP523_01300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61358">
        <property type="protein sequence ID" value="QAS61358"/>
        <property type="gene ID" value="EI377_11800"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00479">
        <property type="entry name" value="RsxG_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01947">
        <property type="entry name" value="rnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FMN_bind" evidence="8">
        <location>
            <begin position="90"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="6">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="259" mass="27312" checksum="BF2A55854DBD97CF" modified="2018-12-05" version="1">MKENFKLGGILLVITALAGLLLGFANSLTKEAILENSKINKEDLKKVLPIAESIRDIDIKINEEGTVKEVYEAIGKSDVVGYVLKVTSKGFHGPVDFVVAISKDDKVSGVKVLAHSETPGLGAKITEDKFTSRFKDKSAKGYLEVVKKSTVKDSELEAISGATISSKAAVSAVNDAIKFYMENIKGEKLAPNGGTDANSGASEEAGAQKEEKATDANSGASEETGTKKEEKKSTDTNTGASEETTTSQKTDVNTGASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK0</accession>
    <name>A0A386PEK0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD</fullName>
            <ecNumber evidence="4">1.1.1.127</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">2-deoxy-D-gluconate 3-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kduD</name>
        <name evidence="3" type="ORF">CP523_03915</name>
        <name evidence="4" type="ORF">EI377_14440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.127" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675516.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01553"/>
    <dbReference type="EnsemblBacteria" id="AYE33674">
        <property type="protein sequence ID" value="AYE33674"/>
        <property type="gene ID" value="CP523_03915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61832">
        <property type="protein sequence ID" value="QAS61832"/>
        <property type="gene ID" value="EI377_14440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047001">
        <property type="term" value="F:2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008678">
        <property type="term" value="F:2-deoxy-D-gluconate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011286">
        <property type="entry name" value="2-deoxy-D-gluc_3_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01832">
        <property type="entry name" value="kduD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="259" mass="28297" checksum="E32E394BC646C9A7" modified="2018-12-05" version="1">MNNNNKFSLDFFNLEGKVAIVTGGNTGLGMAYVEALAAAGADLFVTTFDNNVEEIKGIVEGLGRRIVFIQGDLTKKEFVEEVVDTCVKEYGKVDILVNNAGTIRRAPLLEYKDEDWEAVMNINLNAVYHLSKKVAKIMVEQKSGKIINIASMLSFQGGKFVPPYTASKHGVVGITKAFANELAVHNVQINAMAPGYIKTANTAPIRADENRNKEILSRIPTERWGEVSDLMGTVVFLSSKASDYINGHVIAIDGGWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM8</accession>
    <name>A0A386PEM8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">CP523_00920</name>
        <name evidence="16" type="ORF">EI377_11415</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674548.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02335"/>
    <dbReference type="EnsemblBacteria" id="AYE33116">
        <property type="protein sequence ID" value="AYE33116"/>
        <property type="gene ID" value="CP523_00920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61286">
        <property type="protein sequence ID" value="QAS61286"/>
        <property type="gene ID" value="EI377_11415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00920"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE33116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS61286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="214" mass="22988" checksum="D28A98CFB5721381" modified="2018-12-05" version="1">MVRIAPSILSADFSKLGEEIQSIDKAGAEVIHIDVMDGSFVPNISLGLPVIKSIRNKTSKIFDVHLMIDNPANFIDAFVEAGADIITIHYEADRHIDRAIQYIKSKGVKAGVAINPGTPTTVLKDIIGNLDMVLIMSVNPGFGGQKFIPYALDKIREVKEMSKISNNDLLIEVDGGVDKTNAKALIEAGANVLVAGSAVFGNGKYEENIKALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP4</accession>
    <name>A0A386PEP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE family efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02980</name>
        <name evidence="3" type="ORF">EI377_13495</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679188.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33501">
        <property type="protein sequence ID" value="AYE33501"/>
        <property type="gene ID" value="CP523_02980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61670">
        <property type="protein sequence ID" value="QAS61670"/>
        <property type="gene ID" value="EI377_13495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="453" mass="49692" checksum="01BA6D63A4D55808" modified="2018-12-05" version="1">MKSKVDLISDNIFKTLIKLSLPILGTSFIQMAYNMIDMLWIGRVGSDAVAAVGTAGFFTWFGSALVFISKVGAEIGVSQSIGKDNLKEKNKFVYNSLLINIITALIYTVTLIIFRKQLIGFFNLGDINIINMSIDYLVIVSIGMIFMFLNPLFTGIFNASGNSKTPFIINTIGLVFNIVFDPILIFGMGGFPELGVKGAALATVFAQVIVAIIFIIEFIKNGYSLSLNNKKYIDKLYIFRICKLGLPAALQNGLFSIFAMLIGKIIAGWGPVSIAVQKVGSQIEAISWMTAGGFSTALTSFIGQNYGANKWDRIIKGYKATMIMAIIVGIFATVLLVFFGEQVFSWFIKEADAIEQGKVYLKILGYSQLFMCLEITTAGAFSGLGNTITPSWISIIFTGFRVPLSIILSNIDFLGINGIWWSISGTSMIKGVLIIILFMLMVLIPNKKKIKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU1</accession>
    <name>A0A386PEU1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rsxA</name>
        <name evidence="8" type="synonym">rnfA</name>
        <name evidence="9" type="ORF">CP523_01290</name>
        <name evidence="10" type="ORF">EI377_11790</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675556.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00809"/>
    <dbReference type="EnsemblBacteria" id="AYE33186">
        <property type="protein sequence ID" value="AYE33186"/>
        <property type="gene ID" value="CP523_01290"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61356">
        <property type="protein sequence ID" value="QAS61356"/>
        <property type="gene ID" value="EI377_11790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01290"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="192" mass="20920" checksum="328F8C494B4DD1A8" modified="2018-12-05" version="1">MELFLIFLSAMLVNNFVLSKFLGICSFLGVSKKKDAAFGMGLAVTFVMIIASIMSWLVYNEILVPLELEYLKTIANVLVIAALVQFVEMAMKKLSPGLHKALGIYLPLITTNCAVLGMATLNIQEGYNFIQALVNGVGAASGYMLSIVLLAFIRERIDNNENIPVVLRGLPITLFTAALMSIAFLGFQGLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF03</accession>
    <name>A0A386PF03_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09390</name>
        <name evidence="2" type="ORF">EI377_04135</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678037.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02736"/>
    <dbReference type="EnsemblBacteria" id="AYE34623">
        <property type="protein sequence ID" value="AYE34623"/>
        <property type="gene ID" value="CP523_09390"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60023">
        <property type="protein sequence ID" value="QAS60023"/>
        <property type="gene ID" value="EI377_04135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09390"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="119" mass="14100" checksum="557C3830DD6DCB34" modified="2018-12-05" version="1">MSLEVVGCYRDLNSMKEECKEYSSYHAVLTMNDGSTLDGIIEGLADDDIIMLVGEDVIIGGNGDNMTRQQPMGFNRPNRFRRFRRRRFPINRINRLELLRYPYILPLYPYPYPYPYYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF70</accession>
    <name>A0A386PF70_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF969 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03070</name>
        <name evidence="3" type="ORF">EI377_13570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678421.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01763"/>
    <dbReference type="EnsemblBacteria" id="AYE33518">
        <property type="protein sequence ID" value="AYE33518"/>
        <property type="gene ID" value="CP523_03070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61684">
        <property type="protein sequence ID" value="QAS61684"/>
        <property type="gene ID" value="EI377_13570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010374">
        <property type="entry name" value="DUF969"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06149">
        <property type="entry name" value="DUF969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="233" mass="25042" checksum="A08B74DE89969B30" modified="2018-12-05" version="1">MALIGILIIIIGFALKLNTIAVIISAGIVTGLVSDMSFVDVLSTLGETFVAKREMCLFLLTLPVIGLCERYGLKQMAIMLIEKVKGLSTGKLLTGYLFIRELASTLSVRLGGHPQFIRPLINPMAQGAAIAKYGEIDRKDEDMIKSYAAATDNYGNFFGQNVFMANSGVLLIAGALSELNLPGIGSNVDTLAVAKASIPVAIIAFILGVIQNIYLDRKLSKKYGIKDNKKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF90</accession>
    <name>A0A386PF90_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Formate/nitrite transporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Nitrite transporter NirC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03175</name>
        <name evidence="8" type="ORF">EI377_13690</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02148"/>
    <dbReference type="EnsemblBacteria" id="AYE33538">
        <property type="protein sequence ID" value="AYE33538"/>
        <property type="gene ID" value="CP523_03175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61701">
        <property type="protein sequence ID" value="QAS61701"/>
        <property type="gene ID" value="EI377_13690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="28220" checksum="A0A6190993984A1B" modified="2018-12-05" version="1">MYSNEIHNLAHSAEVKADLLKRSKSRYIVSAMLGSLFISLGIMLIYSIGGIMHHGGSPFYKIIMGVSFGVALSLVLMAGGDLFTSNSMIMTMGALEKSVTWMDALKIWFASWFGNILGGVIGAFLFVQAGLTSGKSDYIGEFIVNNALAKINTPFMPLLIKGILCNILVCLAVWMCYKLKEETAKILMIFWCLFTFITAGFEHSVANMGLLAMGIFIDPSAITVSGYMYNIIVVTIGNFIGGALFLALPYYYITNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD8</accession>
    <name>A0A386PFD8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_03455</name>
        <name evidence="6" type="ORF">EI377_13980</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677899.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02242"/>
    <dbReference type="EnsemblBacteria" id="AYE33588">
        <property type="protein sequence ID" value="AYE33588"/>
        <property type="gene ID" value="CP523_03455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61752">
        <property type="protein sequence ID" value="QAS61752"/>
        <property type="gene ID" value="EI377_13980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="257"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="509" mass="56226" checksum="8894E61ABDDF7F44" modified="2018-12-05" version="1">MEYVVEMLNIRKEFPGIVANDNITLQLKKGEIHALLGENGAGKSTLMGVLFGMYQPEVGKIKIKGKEVKISNPNVANDLGIGMVHQHFKLVSNFTVTENIILGLEPKKGLVVDIKSAAERISELSKKYGLNVDPYAKIEDISVGMQQRVEILKMLYRNAEVLIFDEPTAVLTPQEIQELIKIMKDLVKEGKSIIVITHKLKEIKASADRCTAIRRGKYIGTVDVKTTSEAEMAKMMVGREVSFKVDKKDSNPKETIMSIKNLSVMNNKKVLGLKDFSLDIRKGEIVGIAGVEGNGQTELVEAITGLRPVHSGNIIYNNEDITSIPVRSRVEKGIAHIPEDRHKRGLVLDYTIEENMVLESYNKAPFSKRGLLNKKLIKDHAQKIIDTFDVRSGEGADSIARTLSGGNQQKAIIGREIELNPEVLLAVQPTRGLDVGSIEYIHKRLVEQRDNGKAVLLISLELEEVLNVSDRIAVINNGELVGIVSAKETNENEIGLMMAGVKGGESHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK1</accession>
    <name>A0A386PFK1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CPBP family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06980</name>
        <name evidence="3" type="ORF">EI377_01465</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34217">
        <property type="protein sequence ID" value="AYE34217"/>
        <property type="gene ID" value="CP523_06980"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59582">
        <property type="protein sequence ID" value="QAS59582"/>
        <property type="gene ID" value="EI377_01465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06980"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="291" mass="33447" checksum="58F247015C4DA2ED" modified="2018-12-05" version="1">MVLYVKYNLLIVGGLKLKKLFNKIFSPYRKIEQEQLNISFGIFKAIFILLACNIVEAIFTSIPYFITSDNFLDNNMIVLIPYEIILFFLLPYIWNDISGKNTKVINTYKKFNLKSIIYPFLLVISFRLIYDSLIYPLVMLVPESEFLNEFTSMANNNFLYFFISAILYAPFTEELLFRGIILNGLLGKYSAKISIPISALIFACAHFNFHQGVNAFILGLALGYIFYKTKSLYLTIFCHFINNLIALVTTVPSNPEISYVVTFLSASIGLGLLVLVIMKYRPKYNANFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM9</accession>
    <name>A0A386PFM9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_07100</name>
        <name evidence="7" type="ORF">EI377_01845</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673705.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01035"/>
    <dbReference type="EnsemblBacteria" id="AYE34237">
        <property type="protein sequence ID" value="AYE34237"/>
        <property type="gene ID" value="CP523_07100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59642">
        <property type="protein sequence ID" value="QAS59642"/>
        <property type="gene ID" value="EI377_01845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024187">
        <property type="entry name" value="Sig_transdc_resp-reg_cit/mal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45526">
        <property type="entry name" value="PTHR45526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006171">
        <property type="entry name" value="RR_citrat_malat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="232" mass="27061" checksum="0B44755FEFB1D9A0" modified="2018-12-05" version="1">MINVILVEDDPMVREINYKFLMKIDGFNVIGQVDSIELAKKKIRESDADIILLDVFLPDGRGVDLLRWIRQNNIDLDALLITADNSLNTVNEAFKFGAVDYLVKPFTFKRFKEAFEKYRDRHDKLIEKKTLNQESIDEYILNSGKRNTDNKHNDCDGELAKGLNKNTYNEIWKYISSNITGKFTADELADNVGLARVTVRRYLEYMCKEEKLNLNFEYGKVGRPVHYYEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFN7</accession>
    <name>A0A386PFN7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10850</name>
        <name evidence="2" type="ORF">EI377_05645</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677621.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02504"/>
    <dbReference type="EnsemblBacteria" id="AYE34863">
        <property type="protein sequence ID" value="AYE34863"/>
        <property type="gene ID" value="CP523_10850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60258">
        <property type="protein sequence ID" value="QAS60258"/>
        <property type="gene ID" value="EI377_05645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10850"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="299" mass="34738" checksum="83426624D5BE9B38" modified="2018-12-05" version="1">MKTKDEKKQEKSIIYKEIISPDSFINKYGNKEYVVEGIGSSVSCIMKINKSEDKISNMVIDIIFPEGMSYIPESFVIGIYKEKDLKWLRSKDFIKIKEDKIILNIGNTNSCYYVFYNLKVCEIKKTYLDKTIINYNNITDSLSLTIKYKLNSGVLNANKSVVLEDLDDNKNKRINYNMEFKSYGYFNENYIFFSEKLDNNIKILSVDVPDNFTYKIEDDNTITFFNDKGDINYGDHFNVTIIANVDNIFIEENINNINKNKLDKNINNRSNILLSDDLFIEDNSNIIIQVVNNSEGVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFQ6</accession>
    <name>A0A386PFQ6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04865</name>
        <name evidence="2" type="ORF">EI377_15380</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675761.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33851">
        <property type="protein sequence ID" value="AYE33851"/>
        <property type="gene ID" value="CP523_04865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61997">
        <property type="protein sequence ID" value="QAS61997"/>
        <property type="gene ID" value="EI377_15380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="93" mass="10980" checksum="4AE994BBE99E98D9" modified="2018-12-05" version="1">MLKNKYVLYPESKLESKHEIEMFCKNYFTDLGYTTEIVNESEKFYLYLKINDSLFRVHLRLLGPALDKYKIPLDATISSVVVDQQLVIEKIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFR9</accession>
    <name>A0A386PFR9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="9">PGP-I</shortName>
            <shortName evidence="9">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">pcp</name>
        <name evidence="12" type="ORF">CP523_03060</name>
        <name evidence="13" type="ORF">EI377_13560</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678427.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01765"/>
    <dbReference type="EnsemblBacteria" id="AYE33516">
        <property type="protein sequence ID" value="AYE33516"/>
        <property type="gene ID" value="CP523_03060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61682">
        <property type="protein sequence ID" value="QAS61682"/>
        <property type="gene ID" value="EI377_13560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="213" mass="23141" checksum="A0AB2813ED4EC82D" modified="2018-12-05" version="1">MKVLITGFDPFGGEPINPALEAVKKLPEIISGAEIIKLEIPTVFRKSLEKIEEAIIKKNPDIIISVGQAGGRFGITPERVAINIDDARIKDNEGNQPLDIRIFEDGENAYFSNLPVKAMVKEVTDGGLPASLSNTAGTFVCNHVMYGVLYLINKKYPNKKGGFIHVPYVSSQVISKPNTPYMSLDDITSGLELCIKAAVEHDKDVKVVGGTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS0</accession>
    <name>A0A386PFS0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hyaluronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_04915</name>
        <name evidence="8" type="ORF">EI377_15415</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01694"/>
    <dbReference type="EnsemblBacteria" id="AYE33861">
        <property type="protein sequence ID" value="AYE33861"/>
        <property type="gene ID" value="CP523_04915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62004">
        <property type="protein sequence ID" value="QAS62004"/>
        <property type="gene ID" value="EI377_15415"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033789526" evidence="5">
        <location>
            <begin position="31"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1230"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="680"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="886"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1157"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1162"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1255" mass="140888" checksum="2F9D4A2A1B96E80B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW7</accession>
    <name>A0A386PFW7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA ligase</fullName>
            <ecNumber evidence="11">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">ligA</name>
        <name evidence="13" type="ORF">CP523_09720</name>
        <name evidence="14" type="ORF">EI377_04520</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676734.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02650"/>
    <dbReference type="EnsemblBacteria" id="AYE34680">
        <property type="protein sequence ID" value="AYE34680"/>
        <property type="gene ID" value="CP523_09720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60081">
        <property type="protein sequence ID" value="QAS60081"/>
        <property type="gene ID" value="EI377_04520"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09720"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="585"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="31"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="663" mass="75064" checksum="B81DD28CA3C16876" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG43</accession>
    <name>A0A386PG43_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05595</name>
        <name evidence="2" type="ORF">EI377_00030</name>
        <name evidence="3" type="ORF">EI377_16110</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33981">
        <property type="protein sequence ID" value="AYE33981"/>
        <property type="gene ID" value="CP523_05595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59345">
        <property type="protein sequence ID" value="QAS59345"/>
        <property type="gene ID" value="EI377_00030"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62123">
        <property type="protein sequence ID" value="QAS62123"/>
        <property type="gene ID" value="EI377_16110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05595"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="102" mass="12138" checksum="1E3C3CF0FD59DCE0" modified="2018-12-05" version="1">MKKIKIFLDYQCCPLWAYDEEGELICNELIDELKNETEIEEILDDIQNTYDSLFVDNDIYFEYQGFENEEEKDAFLRKISRVIDLIQLKVGGIYIVENKVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG56</accession>
    <name>A0A386PG56_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-dehydro-2-deoxygluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-5-keto-D-gluconate kinase</fullName>
            <shortName evidence="3">DKG kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">iolC</name>
        <name evidence="5" type="ORF">CP523_11680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-dehydro-2-deoxy-D-gluconate + ATP = 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16669"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57949"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.92"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 5/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.92" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02895"/>
    <dbReference type="EnsemblBacteria" id="AYE35023">
        <property type="protein sequence ID" value="AYE35023"/>
        <property type="gene ID" value="CP523_11680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11680"/>
    <dbReference type="UniPathway" id="UPA00076">
        <property type="reaction ID" value="UER00146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047590">
        <property type="term" value="F:5-dehydro-2-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01668">
        <property type="entry name" value="IolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022841">
        <property type="entry name" value="DKG_kinase_firmi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030830">
        <property type="entry name" value="Myo_inos_IolC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04382">
        <property type="entry name" value="myo_inos_iolC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="13"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="338" mass="37653" checksum="2D6943538DABB62E" modified="2018-12-05" version="1">MRYIKFEENRKFDIVPIGRVAIDFNPTDIHKPLSESRNFNKYLGGSPANIAVGLARLGKKVGFIGKVSDDRFGEFVVNYFKNEGIDISKIAKAKNGESLGLTFTEILSPTESSILMYRNGIADLQLDVNDISETYIKNTKAIVISGTALAMSPSREATLKALRFAKKNKTKVIFDIDYREYNWKNKDEISIYYSIVGKESDIIMGSREEFDLMEGLITKNSTDEETATRWLSCGNKIVVIKHGKDGSTAYTGDGKSYRIKPFPVKLLKSFGGGDAYASAFIYGILEGWNIMEALEFGSASAAMLVASHSCSEDMPTVESINEFIKKEKEEYGEMVARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG71</accession>
    <name>A0A386PG71_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ORF">CP523_07085</name>
        <name evidence="4" type="ORF">EI377_01830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673698.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01032"/>
    <dbReference type="EnsemblBacteria" id="AYE34234">
        <property type="protein sequence ID" value="AYE34234"/>
        <property type="gene ID" value="CP523_07085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59639">
        <property type="protein sequence ID" value="QAS59639"/>
        <property type="gene ID" value="EI377_01830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07085"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="255" mass="28959" checksum="20F54711D11C1CD3" modified="2018-12-05" version="1">MDPIAFEAFGIEIRWYGIIISMGVIAAMILTYFMAKKKKLDFEVIIDAFLWVFPFSIIGARLYYVAFEYQNYHSFMDVINIRQGGMAIHGGVIAGLIVGVIFAKVRKINFFEYVDIVMPGVILAQAIGRWGNFMNQEAHGGPVTKEFISKFPEFIQNGMHISGVYYHPTFLYESVWNLLVCGILIYILLKSEKSEAGVILGSYMMLYSLGRFFIEGLRTDSLMFLGLRIAQIVSIIGILLGIGLIVWVKKRKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI8</accession>
    <name>A0A386PGI8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676446.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33766">
        <property type="protein sequence ID" value="AYE33766"/>
        <property type="gene ID" value="CP523_04395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017420953" evidence="1">
        <location>
            <begin position="30"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="210" mass="24011" checksum="CE6FF7C769058A23" modified="2018-12-05" version="1">MIKNKKSRYIILGLCLSFITLINTPRVYASVEEIKNWFTARDEVSNNFINGDIDISIEEDFKEPENWDGLNHDKKVAIQNNGKSDAFIRVSIVPRWVDENGKPWIGDSNYVDLTFVNVTEDLNTANAAWIKGEDGYYYYNQIVKTTNKTVDLLESVALNIPTDKKDVYKNRKLIVDVKSETVQATSNAYLKVWEGVPESIKIVLDRLLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM3</accession>
    <name>A0A386PGM3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04005</name>
        <name evidence="3" type="ORF">EI377_14525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676934.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02785"/>
    <dbReference type="EnsemblBacteria" id="AYE33692">
        <property type="protein sequence ID" value="AYE33692"/>
        <property type="gene ID" value="CP523_04005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61847">
        <property type="protein sequence ID" value="QAS61847"/>
        <property type="gene ID" value="EI377_14525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04005"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="278" mass="30787" checksum="D3BB3B56E192A5B9" modified="2018-12-05" version="1">MQKIKIVTDSCLDIPQEMIKKNNIEVLPVLINFGEESYIDMEEINPKEMQERIEKENILPTTSQVTPSRFEECFRKNLEEGYKVIAIIMSSNMSGTYQSACLAKNMVESDDIVIIDTQTITSGQGLLVLKACKLRDEGLSLEEIEKEILNTIPKVKSSLAFESLENLVRGGRISKAAGAIGTALGLRIILEVKDGIMSVKDKVRGSKKAFKKIISDYEAANVDPNEPVMLLQCENPELYAVLKEYLTSNNIKHIDTEVGCAVGIHSGPKAGGLFFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGN5</accession>
    <name>A0A386PGN5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34038">
        <property type="protein sequence ID" value="AYE34038"/>
        <property type="gene ID" value="CP523_05925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="261" mass="30667" checksum="4B6878F6C0024C5D" modified="2018-12-05" version="1">MKKNISIIFLFITLTFISFINVIDINLFLSTLSSKFNNISMQDIVIYMLYGLTSSSRVNLIDIIRFSIPFILCIGFINSYLSDILESNTIYLNIIRYKSYSSWIKTYLFKMTLLIILFYTYYYINLIIISSIYTKNVSGFTDTFYYLNRYMTNTNFFQLLIYQYFLSIFSTILLTLINLLLSLVLKNINKSFIVVIVTILILTALGKYDIINPLMLSKHYTINYNFNINPISTLTFHLLFSFIIYISLVRCIKLLVRRTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP2</accession>
    <name>A0A386PGP2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06950</name>
        <name evidence="3" type="ORF">EI377_01435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01004"/>
    <dbReference type="EnsemblBacteria" id="AYE34211">
        <property type="protein sequence ID" value="AYE34211"/>
        <property type="gene ID" value="CP523_06950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59576">
        <property type="protein sequence ID" value="QAS59576"/>
        <property type="gene ID" value="EI377_01435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022387">
        <property type="entry name" value="Bind_CPR0540"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03850">
        <property type="entry name" value="bind_CPR_0540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033787982" evidence="1">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="450" mass="49410" checksum="F264DB6A2A978F71" modified="2018-12-05" version="1">MKKRRIALLLSSFMLISTLAGCGTKGGEEPNNAGKENKVLKVAAFEGGYGKVYWEKLKENFEKAHEGVTVELTVANNLEEVIRPQVQSGNVPDLVYLATGRKEALTETFIKEQGLHDLSGVLDKKVPGEDVTVKDKILPGFLDTSATNPYGDGKTYLAPLFYSPTGLFYNKGLFKEKGYELPKTWDEMFALGDKAKNDGIALWSYPTAGYYDGTIAAMLAGTGGVQAFEDAMNYKEGFWNSDSAKLALDTIAKLKDYLEPSVVANANDQGFKNNQQLILDNKALFIPNGTWLPDEMKDAPRADGFEWGFMAYPAFKTGGDQYSYNFFEQMYIPKDAANKELAEDFMAYMYSDEAVKVIAENAKAVVPVKGAIEIASKSLDSLQIEMFKIYENGAKPVMGGFAATEPVEGVTFGDIYTGTVDSIMTGEKTVADWQKALQEASDKLRAAIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP4</accession>
    <name>A0A386PGP4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CotS family spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02165</name>
        <name evidence="3" type="ORF">EI377_12685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674055.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00534"/>
    <dbReference type="EnsemblBacteria" id="AYE33349">
        <property type="protein sequence ID" value="AYE33349"/>
        <property type="gene ID" value="CP523_02165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61519">
        <property type="protein sequence ID" value="QAS61519"/>
        <property type="gene ID" value="EI377_12685"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="49"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="355" mass="42056" checksum="AF899659A9DCEA4B" modified="2018-12-05" version="1">MENIKYNKNSREELLSLDKIKSFILSNYELEQADVTMVKFKDTEKQRAVYKVDYKTKTYCLKKVYYDENNLLYVYSAMEWLYRNSISVPKLLPTITNHRYVLYSDMLFILTPWLEGEKCNFDNIDHLNISAKTLGALHKVSINFTPIEGSCLRKGLENYHLSTYKHFNQLLNAVNNAHKHKDKFSNIFLDNLDENLRLAKLSVEISSSIDLQDLSISLCHGDYVNKNIIINNDNVSIIDFDKCKLDYCAHDLAYFLRRLLKRENTNWNAELAIMVINNYMLSNNLTKSDLKYILAYITFPQKYWKLSRDYYKNIKKCNKASFVRLLEKGVLRTSYQLEFVYEMIKIFQDKYNIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU5</accession>
    <name>A0A386PGU5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF2691 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF2691 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04835</name>
        <name evidence="2" type="ORF">EI377_15345</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675774.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33846">
        <property type="protein sequence ID" value="AYE33846"/>
        <property type="gene ID" value="CP523_04835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61992">
        <property type="protein sequence ID" value="QAS61992"/>
        <property type="gene ID" value="EI377_15345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020216">
        <property type="entry name" value="Uncharacterised_YncE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10903">
        <property type="entry name" value="DUF2691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="151" mass="17648" checksum="65259971716DB0F2" modified="2018-12-05" version="1">MVNGLRCDIPNEWGRYLFDILKGIDIHKYNWHVDNDEVIICSKDNEYKSLFDSTSLRGGELYDRICNEKYYVIFLELTGQYGTSNIPQIETYNDFVEGNCEIFLVVTDCSYLEVYCKNSDELKIIERNLKELSLIPETITEETLRSSLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV0</accession>
    <name>A0A386PGV0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_11610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02880"/>
    <dbReference type="EnsemblBacteria" id="AYE35010">
        <property type="protein sequence ID" value="AYE35010"/>
        <property type="gene ID" value="CP523_11610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11610"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="321" mass="35951" checksum="91612434361A13BA" modified="2018-12-05" version="1">MIEINNLNKKFGSLEVLKDISLNIKEGEIYGLIGHSGAGKSTLLRCINGLESYDSGSVKVMGKEVKSLNNNKLRQFRKDLGMIFQNFNLLERKSVFDNVAIPLEVWGYDKSYIQKKVRDLLKLVGLEEKAKCKPRELSGGQKQRVAIARALALEPKVLLCDEATSALDPKTTKDILSLLLQINKELGITIVIVTHQMEVVKEVCEKVALIEGGFLKVEGQAEKLFLKPGVSLKKFLGDDDDELLPNTGVNIKLFFPSTSSENALITKMSREICVDFSIVWGKLEKFRDNVLGSLVINVEEKDKEKIIGYLQDRNIILEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV8</accession>
    <name>A0A386PGV8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_08335</name>
        <name evidence="7" type="ORF">EI377_03080</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674765.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01608"/>
    <dbReference type="EnsemblBacteria" id="AYE34434">
        <property type="protein sequence ID" value="AYE34434"/>
        <property type="gene ID" value="CP523_08335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59837">
        <property type="protein sequence ID" value="QAS59837"/>
        <property type="gene ID" value="EI377_03080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="62" mass="6446" checksum="A61E4DE71E73C2AC" modified="2018-12-05" version="1">MKAKVDKDTCIGCGLCPSICPEVFEMDDDGKAVAKVADVPDSNVDEAKDAESSCPVSAIIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH29</accession>
    <name>A0A386PH29_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fsa</name>
        <name evidence="9" type="synonym">tal</name>
        <name evidence="10" type="ORF">CP523_05210</name>
        <name evidence="11" type="ORF">EI377_15770</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676240.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01831"/>
    <dbReference type="EnsemblBacteria" id="AYE33916">
        <property type="protein sequence ID" value="AYE33916"/>
        <property type="gene ID" value="CP523_05210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62067">
        <property type="protein sequence ID" value="QAS62067"/>
        <property type="gene ID" value="EI377_15770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05210"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS62067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="23377" checksum="14E67DBE0074EB22" modified="2018-12-05" version="1">MKLFVDTANVEDIRKANDLGVICGVTTNPSLIAKEGRDLKEVIDEICSIVDGPISAEVMALKAPEMIEEGRELAKLHKNIVIKIPMCEEGLKAVSVLSKENIKTNVTLIFSPLQALLAARAGATYVSPFLGRLDDIGNPGIDLVRNIVEIFEIHGIETEIISASVRNPMHVLDVALAGSHIATVPYSVIAQMTKHTLTDVGMAKFIADYEKAFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH32</accession>
    <name>A0A386PH32_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Capsular biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_04970</name>
        <name evidence="10" type="ORF">EI377_15470</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675720.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01683"/>
    <dbReference type="EnsemblBacteria" id="AYE33872">
        <property type="protein sequence ID" value="AYE33872"/>
        <property type="gene ID" value="CP523_04970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62014">
        <property type="protein sequence ID" value="QAS62014"/>
        <property type="gene ID" value="EI377_15470"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04970"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="8">
        <location>
            <begin position="149"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS62014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="225" mass="25279" checksum="9A8EEA16307C7628" modified="2018-12-05" version="1">MEKEINLIDLIKSLKKRWKVILVTTLLTTILSALITLFLIKPKYETKVKLFIGKEETAQEGYNQNDILMYQKLLKTYSEVIKTRDLINVAISKSNANETTGDVLNNLTVVPVSDTQILEVKYKNSSPEISLKLINAITDEFVKQSTDLVPNGNVKVLESASLPEKPVSPNKTINILISFLLGLMVGVGIVFLLEFLDNSFKTKKQIEDELDIPVIGVIPKFLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHB0</accession>
    <name>A0A386PHB0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_08420</name>
        <name evidence="6" type="ORF">EI377_03165</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674799.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01625"/>
    <dbReference type="EnsemblBacteria" id="AYE34451">
        <property type="protein sequence ID" value="AYE34451"/>
        <property type="gene ID" value="CP523_08420"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59854">
        <property type="protein sequence ID" value="QAS59854"/>
        <property type="gene ID" value="EI377_03165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="29724" checksum="5A3C8660464510FF" modified="2018-12-05" version="1">MEAISVKNLSVAYENNTIIEDMDLSIQKGKINIIIGANGCGKSTLLKTIARINKPKSGDIFVNNKNLKKIKEKYIAKEIAFLPQGPVCPSGLTVRELVAYGRFPHQKIIGGLNNHDKEIIDWAIEETGLNEFANREVENLSGGQRQRAWIAMTLAQETDIIMLDEPTTYLDMSYQLEVLEVLQKLNKEKNITVVIVLHELNNACRFADNIIGLKKGKIICEGKPIDVINKETLRKIYGIEANIKTSENGEYPVCTEYELFREDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHT2</accession>
    <name>A0A386PHT2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11170</name>
        <name evidence="3" type="ORF">EI377_05960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677055.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00906"/>
    <dbReference type="EnsemblBacteria" id="AYE34927">
        <property type="protein sequence ID" value="AYE34927"/>
        <property type="gene ID" value="CP523_11170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60321">
        <property type="protein sequence ID" value="QAS60321"/>
        <property type="gene ID" value="EI377_05960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11170"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="65" mass="7516" checksum="DCAEF24DA94115FB" modified="2018-12-05" version="1">MKNKRMKIARIECDLSQEQLAEKVGVTRQTIGMIESGKYNPSLNLCILICKSLNKTLNDLFWKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW0</accession>
    <name>A0A386PHW0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_08515</name>
        <name evidence="5" type="ORF">EI377_03265</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674858.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01644"/>
    <dbReference type="EnsemblBacteria" id="AYE34468">
        <property type="protein sequence ID" value="AYE34468"/>
        <property type="gene ID" value="CP523_08515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59871">
        <property type="protein sequence ID" value="QAS59871"/>
        <property type="gene ID" value="EI377_03265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08515"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="274"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="375" mass="41726" checksum="DBBF10928E571586" modified="2018-12-05" version="1">MFNNKYNCKNEDNNSSKNDSTINFKMKKANTRCKLGKGLVIFLVLLILLILTVSNVSLIRKYNKIMEQRNKINLKVGSEVFEYDKITHQISESIVAISNEESKLTKNSYFEPNLTGVILSEEGTILTNYSKIKDFRDIYVKLPSSGSMPIKASLVGISEDVDVAIIKIYYKGKLSPIKIANEDEVIEGQEIAVLSNSIGNEYIERVIPGIITSTHQTIKDKSDREHRLLEISSLINENNTGGAICNSKGELIGLASVDITNKKNKQGLYYAIDLRELQKISQVTDVFKSKLGISGGLIEDPKSRLKGFYVENVKESGVAYNAGIRATDIIIQLDGVDILTVNDLSNIMINKKAGEKVLCKIVNNGNIKELELLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHY3</accession>
    <name>A0A386PHY3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Chorismate synthase</fullName>
            <shortName evidence="10">CS</shortName>
            <ecNumber evidence="4 10 11">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aroC</name>
        <name evidence="12" type="ORF">CP523_11390</name>
        <name evidence="13" type="ORF">EI377_06205</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="10 11">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="protein sequence ID" value="AYE34967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="QAS60360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
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    <dbReference type="STRING" id="1504.GCA_900092375_02834"/>
    <dbReference type="EnsemblBacteria" id="AYE34967">
        <property type="protein sequence ID" value="AYE34967"/>
        <property type="gene ID" value="CP523_11390"/>
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    <dbReference type="EnsemblBacteria" id="QAS60360">
        <property type="protein sequence ID" value="QAS60360"/>
        <property type="gene ID" value="EI377_06205"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11390"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
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        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
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    </dbReference>
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        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <begin position="305"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
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            <dbReference type="ARBA" id="ARBA00022857"/>
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            <dbReference type="ARBA" id="ARBA00023141"/>
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            <dbReference type="ARBA" id="ARBA00023239"/>
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            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AYE34967.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QAS60360.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="360" mass="39241" checksum="F65DFFBC1831AC0B" modified="2018-12-05" version="1">MSGIWGNNLKVSIFGESHGIGIGITIDGLPSGFEIDMEKVMMEMSRRAPGKSSISTARKEGDIPEILSGYFEGKTTGTPLCAMIRNGDTRSKDYGKLKDLMRPGHADYTGNIKYKGFNDYRGGGHFSGRITAPLVFAGAICKQILEEKGIFIGAHINSISNIKDKSFFDISDINKENLLELRQCELPLINNKIEENIRRVILETKSKGDSLGGTIECVILGVEAGIGDPFFDSVESTLAHLMFSVPAVKGIEFGKGFEMTTMNGSECNDEYCYEEGKIKTKTNNNGGILGGITNGMPIIFKVAIKPTPSIIKEQQTIDIKNKENTTLKIEGRHDPCIVQRALPVIEAVTAIGLVDLIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHZ9</accession>
    <name>A0A386PHZ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS sugar transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_09960</name>
        <name evidence="6" type="ORF">EI377_04745</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="QAS60102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AYE34701">
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        <property type="protein sequence ID" value="QAS60102"/>
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        <property type="term" value="F:kinase activity"/>
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    </dbReference>
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        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="99" mass="10968" checksum="1AFEC4B8192D974F" modified="2018-12-05" version="1">MKKIVLLCSEGMSTCFLVSKMKTEALNQGVDCIINSCCESDLGTFKDNMDVLLLAPQIKFLKEEITTKFKNVPIGVINSLDYGTMDGVKVFNQALELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PID8</accession>
    <name>A0A386PID8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14655</name>
        <name evidence="3" type="ORF">EI377_09620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00143"/>
    <dbReference type="EnsemblBacteria" id="AYE35885">
        <property type="protein sequence ID" value="AYE35885"/>
        <property type="gene ID" value="CP523_14655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62198">
        <property type="protein sequence ID" value="QAS62198"/>
        <property type="gene ID" value="EI377_09620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="1">
        <location>
            <begin position="109"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="29840" checksum="A7293A7B841BD18A" modified="2018-12-05" version="1">MELQNTFNNINEDKLKGFNGEEIKKVQSYVNDFDNEFKERHYKSAREILSNLNIYINDVQKEATARRIKETYDEKSSEDPSLRQPKYINGILLVNKEYGLPDSYGSGEDKEAREAFEKMKSDAAKEGIYLYAFSTYRSYWSQNSLYWNYVSNYGEDPTDTFSAKPGFSEHQTGLAFDIGGVDRSLWAEDDFKNTKEAEWLKNNSYKYGFILRYPEGKEWKTGFVFESWHFRYIGPEHSKHFKDSNLTLEEYLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF0</accession>
    <name>A0A386PIF0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05275</name>
        <name evidence="3" type="ORF">EI377_15835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676268.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01844"/>
    <dbReference type="EnsemblBacteria" id="AYE33929">
        <property type="protein sequence ID" value="AYE33929"/>
        <property type="gene ID" value="CP523_05275"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62080">
        <property type="protein sequence ID" value="QAS62080"/>
        <property type="gene ID" value="EI377_15835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05275"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038727">
        <property type="entry name" value="NadR/Ttd14_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13521">
        <property type="entry name" value="AAA_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_28" evidence="1">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="194" mass="22425" checksum="94CE3A2F0B3ECFF1" modified="2018-12-05" version="1">MPKRIAILGGPRCGKTTLIQQLYVEMKIRDLNVGVATEYSTDYLRDKGMIETISEQYGIYLGQLHIEESLNSFDYALTDYATFVPYIYGRFMLGDKKRSIKEIEILKDLYVLALRDLPKYDHIFFVPREFGYSKDGVRWQDEEIAKAVDKAILSFLEAENVNYTVITGSTKKRSEKILEIVGIVDKEEKKVEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PII6</accession>
    <name>A0A386PII6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein DivIVA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">DivIVA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_14925</name>
        <name evidence="8" type="ORF">EI377_09880</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676070.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01299"/>
    <dbReference type="EnsemblBacteria" id="AYE35620">
        <property type="protein sequence ID" value="AYE35620"/>
        <property type="gene ID" value="CP523_14925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61006">
        <property type="protein sequence ID" value="QAS61006"/>
        <property type="gene ID" value="EI377_09880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="198" mass="23189" checksum="D5109FE731628172" modified="2018-12-05" version="1">MKLTPMDINNKEFKKVLRGYSQEEVDEFLDEIVENYEEVYKENSRLKESLARSNDQLEHYSKIENTIQNTLLLAQNAAEQARENSQKEAEIIIKNANETAQKIVDKAHTDVISINDEYEKVRQEFIKFRAKFRNFMNTQTETFDELERDLTKNYSVAEPVEEAVEEKNIQLSEAAIEIVSEEACTEDMEEIKSFFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIM9</accession>
    <name>A0A386PIM9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_11360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673257.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34961">
        <property type="protein sequence ID" value="AYE34961"/>
        <property type="gene ID" value="CP523_11360"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11360"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01046">
        <property type="entry name" value="Rubrerythrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045236">
        <property type="entry name" value="Rubrerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="51"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="180" mass="19848" checksum="CBE6ABB7E34CA51E" modified="2018-12-05" version="1">MKKFVCTVCGYVHEGDAAPEKCPLCQVGADKFVEQSGDLAWADEHRVGVAKDVDPRIMEGLQANFMGECTEVGMYLAMSRQADREGYPEVAEAYKRIAWEEAEHAAKFAELIGEVVAADTKANLQARVNAEHGACQGKKELATLAKQLNLDAIHDTVHEMCKDEARHGMAFAGLLNRYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIP9</accession>
    <name>A0A386PIP9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05585</name>
        <name evidence="2" type="ORF">EI377_00020</name>
        <name evidence="3" type="ORF">EI377_16100</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33979">
        <property type="protein sequence ID" value="AYE33979"/>
        <property type="gene ID" value="CP523_05585"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59344">
        <property type="protein sequence ID" value="QAS59344"/>
        <property type="gene ID" value="EI377_00020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62121">
        <property type="protein sequence ID" value="QAS62121"/>
        <property type="gene ID" value="EI377_16100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05585"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="184" mass="21468" checksum="8893C37588EEFE47" modified="2018-12-05" version="1">MKIWDLQEDVNVYEHITLVNGSNEDWIKFGDMFQGKQLREEWQPLKLKLIQHGGTLKKGDMPYLSPGVPVFSDKAIHVLKSQFSSCVEVLDTDCDIGDYKIINVIKVINCLDYEKSEILRYRDSDRIKAISKYVFKLDLIEKLNIFKIVEQPRGKVFVSDEFRNKVIQSGLEGFKFIEVWDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIT6</accession>
    <name>A0A386PIT6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12080</name>
        <name evidence="3" type="ORF">EI377_06910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673499.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02973"/>
    <dbReference type="EnsemblBacteria" id="AYE35094">
        <property type="protein sequence ID" value="AYE35094"/>
        <property type="gene ID" value="CP523_12080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60487">
        <property type="protein sequence ID" value="QAS60487"/>
        <property type="gene ID" value="EI377_06910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="155" mass="17504" checksum="388E9BA46DCBC911" modified="2018-12-05" version="1">MLKLSPIELFFRAIPEGFLFILAIYSFSRIKINKKRYVLSSFLYSILVFLVRFLPITYGGHIVINIGIAILIGHLINKIDMLDIIKSVIGIFIIQFSSEGVNLLIIQTFAKSNIEKIVSDPVLKTIYGIPSLVIVAVVITIYYLLMNNKGKLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIV6</accession>
    <name>A0A386PIV6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS sugar transporter subunit IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05985</name>
        <name evidence="6" type="ORF">EI377_00465</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675068.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01899"/>
    <dbReference type="EnsemblBacteria" id="AYE34049">
        <property type="protein sequence ID" value="AYE34049"/>
        <property type="gene ID" value="CP523_05985"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59421">
        <property type="protein sequence ID" value="QAS59421"/>
        <property type="gene ID" value="EI377_00465"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05985"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIB type-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="102" mass="11203" checksum="25F753692700C8A2" modified="2018-12-05" version="1">MKVLFVCSQGMSSAIAVNALKKEAEKNGIDMEVLAVSTQEFEEEVKNGYDVAMVAPQVRHRFDYLKEFAENANVPCALIQPQAYSPLGGPKLLKQVKELAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIX5</accession>
    <name>A0A386PIX5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3892 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06135</name>
        <name evidence="3" type="ORF">EI377_00615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675137.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01927"/>
    <dbReference type="EnsemblBacteria" id="AYE34079">
        <property type="protein sequence ID" value="AYE34079"/>
        <property type="gene ID" value="CP523_06135"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59449">
        <property type="protein sequence ID" value="QAS59449"/>
        <property type="gene ID" value="EI377_00615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024997">
        <property type="entry name" value="DUF3892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13031">
        <property type="entry name" value="DUF3892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="100" mass="10657" checksum="A5C77C9E2F93F7DB" modified="2018-12-05" version="1">MNNQNDGMMGGLPININKEVPTPNSDAKSITALIKHSGEVIGYELSNGERISKEEGVQMAKSGNIQGVAIGVSKKGEEYLRSLPDQDESNNLSALPTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY3</accession>
    <name>A0A386PIY3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ethanolamine utilization protein EutP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12445</name>
        <name evidence="3" type="ORF">EI377_07330</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EutP/PduV family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675330.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02024"/>
    <dbReference type="EnsemblBacteria" id="AYE35164">
        <property type="protein sequence ID" value="AYE35164"/>
        <property type="gene ID" value="CP523_12445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60567">
        <property type="protein sequence ID" value="QAS60567"/>
        <property type="gene ID" value="EI377_07330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:cellular biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012381">
        <property type="entry name" value="EutP_PduV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40453">
        <property type="entry name" value="PTHR40453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10662">
        <property type="entry name" value="PduV-EutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036409">
        <property type="entry name" value="EutP_PduV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="148" mass="16741" checksum="37AE483315CB37BE" modified="2018-12-05" version="1">MKRKRIMVIGPSRCGKTTLVNALNDYKGPLRRTPDLIYGKNTIDVPAAYVENAWMYKNIIATAQDASHVLILVDQSNCTEIYSYGFAKCFRCPVIGVITKCDLSPENEKKCLKQLKDIGVLEPYFHVSFPMEIGINDLKQYLFGKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIZ2</accession>
    <name>A0A386PIZ2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LytR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10875</name>
        <name evidence="4" type="ORF">EI377_05670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677629.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34868">
        <property type="protein sequence ID" value="AYE34868"/>
        <property type="gene ID" value="CP523_10875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60263">
        <property type="protein sequence ID" value="QAS60263"/>
        <property type="gene ID" value="EI377_05670"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="89"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="328" mass="36976" checksum="6556073394F3D31C" modified="2018-12-05" version="1">MDNGVKKIKKSSYLKKTLLILLVVLVLGVIGASIYGFNLINKINKINTTEEDIGINKEATEELSKYNNYDKIINIALFGIDAGENEFGRSDSIMILTIDPIHNKMKLSSIMRDSYVNIEDHGMDKINHAFAFGNSVLALKTLNNNFGLNINNFISTDFSNLPKIIDKLGGIELNITSDELKYINSYIDNLNVLNSTSSPHLDSTGKQLLDGTQCLAYSRIRYTDGGDYERTWRHRTILKGVYDKVKDTKVSELPSLLNDFLPFIETNLGTTELLNIGSTINKIGSSSLIEDRFPRDGYCEGKMIEGVYYLTFDLDTTKQQMKEFIFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ58</accession>
    <name>A0A386PJ58_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_12700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675188.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01969"/>
    <dbReference type="EnsemblBacteria" id="AYE35211">
        <property type="protein sequence ID" value="AYE35211"/>
        <property type="gene ID" value="CP523_12700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12700"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="224" mass="26013" checksum="3020E919CED1ED55" modified="2018-12-05" version="1">MYKVLIVEDDRVISSLLKENLCKWGYEVECISDFSNVIGEFIQFNPQLVVMDINLPFYNGYHWCTEIRKMSKVPIMFASSESDNINYIMAINMGADDFIVKPFDLNIFVAKVQALLRRAYSFQGKMNVLESKGAILNLEEVTLTYKEKKLSLTKNEFKILQILLENKNKAVSREDIMTYLWESESYIDDNTLTVNVTRIRKRLEEIGLKDFIKTKKGIGYIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ67</accession>
    <name>A0A386PJ67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_09915</name>
        <name evidence="7" type="ORF">EI377_04700</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676528.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00312"/>
    <dbReference type="EnsemblBacteria" id="AYE34692">
        <property type="protein sequence ID" value="AYE34692"/>
        <property type="gene ID" value="CP523_09915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60093">
        <property type="protein sequence ID" value="QAS60093"/>
        <property type="gene ID" value="EI377_04700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="112"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="227"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="459" mass="49493" checksum="A84BA624CB64B457" modified="2018-12-05" version="1">MLSKSIASRVLARCLITGGDFAEIFEEDTIDTSISILNGKVENSVAGRSYGIGIRIFKGFKSIYAYTNNNSLTSLLDTAQKAALALGELKEDGNVILTDRFNNNIHPIIYLPSSIGIDKKIGIMKTAYKSAKDYSSEISQVSVGYADKEQNILIANSEGLYTEDKRVRTRLAISSVASYNGENQTGFEGPGRHMGFEMFREIDPEYYGKEASRVAYTMLHAKHCPAGKMAVAIDNGFGGVIFHEACGHSLEATAVAKGNSVFTGMLGKQIASPKVTAIDDGTIPNAWGSLNIDDEGNKTRKNILIENGILKSYMIDKLNGRRMGMEPTGSSRRQSYKYAPTSRMTNTYIASGEDNPDDIIKSISHGLYAKKMGGGSVNPVTGEFNFAVSEGYIVKNGIIQEPVRGASLIGKGSEVLMNIDMVGNNLEYGQGMCGSSSGSIPTNVGQPMIRVKEITVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ68</accession>
    <name>A0A386PJ68_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidored_nitro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11340</name>
        <name evidence="3" type="ORF">EI377_06160</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673250.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02825"/>
    <dbReference type="EnsemblBacteria" id="AYE34958">
        <property type="protein sequence ID" value="AYE34958"/>
        <property type="gene ID" value="CP523_11340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60353">
        <property type="protein sequence ID" value="QAS60353"/>
        <property type="gene ID" value="EI377_06160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="1">
        <location>
            <begin position="14"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="408" mass="46379" checksum="1FA800571B9F394F" modified="2018-12-05" version="1">MSLCRYLPTPSDRMGLLWTLLSIEDTVVIEFGPTGTTHYSASFFGKIGVEQENRLFATHMSEDDVIMGCTETLEEAIIEVDKWISPKAIFVVASSVSAIIGTDLKGVCRAIQPKVSTKLYALENGGFRGDYSNGIKIAYESLFHKMLGEKTEKIKGTYNILGASMYTYRMRSDINEIKDLMKESFDYDVIATLSVDTSENIIKNSVKAELNIVTSFEALPLAKHMEENYDIPYIYGAPYGYSGTSEWLNEISEIISTPINIEMKQKVMKRIMSIKHYPMYKRMLKIFKPTMSIYSEYDRMLGFKKIAKEIGFNIDSYVCNHSIKGINDDNVTTLNSEKERIDLFSKKNHQLIISDDITLRMTDSTNKKFRASMPIVVGSQIANHMPLIGLKGMDYFLEFVDDYIQNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ94</accession>
    <name>A0A386PJ94_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10080</name>
        <name evidence="2" type="ORF">EI377_04880</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676583.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00345"/>
    <dbReference type="EnsemblBacteria" id="AYE34722">
        <property type="protein sequence ID" value="AYE34722"/>
        <property type="gene ID" value="CP523_10080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60123">
        <property type="protein sequence ID" value="QAS60123"/>
        <property type="gene ID" value="EI377_04880"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="101" mass="12343" checksum="94DA42E736CF6C6A" modified="2018-12-05" version="1">MEDYIDGLDKINIVINILCKQFNMKKEDLNKFIKKRENKYLLLLLLKNYKCLKKEDLEEIKNIINGKMINYNLKKAEEKLLINKDFRELYFKIEERLDKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJB0</accession>
    <name>A0A386PJB0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="10" type="ORF">CP523_11550</name>
        <name evidence="11" type="ORF">EI377_06365</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673333.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02868"/>
    <dbReference type="EnsemblBacteria" id="AYE34998">
        <property type="protein sequence ID" value="AYE34998"/>
        <property type="gene ID" value="CP523_11550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60391">
        <property type="protein sequence ID" value="QAS60391"/>
        <property type="gene ID" value="EI377_06365"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11550"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="10"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="88"/>
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        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
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            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="407" mass="45403" checksum="12E6D6E8079A6CAF" modified="2018-12-05" version="1">MKKFKKVVLAYSGGLDTSIIISWLKENYGCDVIAVVGNVGQKDELTGLEAKALMTGASKCYIEDLTNEFVYDYVFPTIQSNAVYEGKYLLGTSFARPIIAKRIVEIAKSEGADAICHGCTGKGNDQVRFELAIKAFAPDMKIIAPWRIWNIKSREEEIQYALDKNIPISISYETNYSKDKNLWHLSHEGLDLEFPENEPNYEKILEMSNTLENAPNIPTYITLSFEKGIPVALNGKKLDGVTLIEKLNKIGGENAIGIVDMVENRLVGMKSRGVYETPGGSILYKAHKDLEELCLDKETAHYKQIIALKFADIVYNGQWYTPLRESLSAFISKTQENVTGEIKLKLYKGNIVNAGMTSPYSLYSEEYATFGKDDVYNQNDSAGFINLFGLPIAVKAKMDSVLKNGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJE6</accession>
    <name>A0A386PJE6_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">DUF1097 domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">CP523_14800</name>
        <name evidence="3" type="ORF">EI377_09760</name>
    </gene>
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        <name type="scientific">Clostridium septicum</name>
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            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
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        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF1097"/>
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            <begin position="12"/>
            <end position="41"/>
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            <begin position="102"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="QAS60983.1"/>
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            <dbReference type="Proteomes" id="UP000280586"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
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    </evidence>
    <sequence length="153" mass="16592" checksum="FF6DD14E25ACF138" modified="2018-12-05" version="1">MDLLTMISISVGILSGVWGFVSASLGLITWVGFIGCTSYYASGGEFVGFKKSIYANITGVFWGMCIIICSSQFEASYWSYIFTGVFSFVMCIQAKYKKLDFIPGAFCGACCIFGTGGEWQAVIIALLCGAVLGYLSDKGGQYLYKLSEHLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG1</accession>
    <name>A0A386PJG1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprF</name>
        <name evidence="7" type="ORF">CP523_13625</name>
        <name evidence="8" type="ORF">EI377_08515</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679019.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00081"/>
    <dbReference type="EnsemblBacteria" id="AYE35384">
        <property type="protein sequence ID" value="AYE35384"/>
        <property type="gene ID" value="CP523_13625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60773">
        <property type="protein sequence ID" value="QAS60773"/>
        <property type="gene ID" value="EI377_08515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13625"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="309" mass="35303" checksum="4DCE5C9809EBF8D4" modified="2018-12-05" version="1">MKKIINNLAVRIIQILVMAIILVVVTKELYRIFIDMNIQLFYKYSDKLTVVNIFIIVLLGIISYIPLSFYDLVIRKKVGIALDTKKVYKYSWIASSVANIVGFGGSAAIVLKRYFYKDYVDDEKKLIKETSKVVGLNLSGFSLLCLIYSIYLFTIERNISYIDYIAIIIAMYLPIIIITITYKYIKNGDRYSYRTTLKIISISILEWITTISLIIGLIYILNINVSIFDFLPIYVVGIVAAIISMAPSGLGTFDLVLIVGLDKFNVPKEQVLLLIILYRISYYIIPLLIGVILYLSDLLSKLVKNENME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJH0</accession>
    <name>A0A386PJH0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antiterminator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate responsive antiterminator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13395</name>
        <name evidence="2" type="ORF">EI377_08285</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00774"/>
    <dbReference type="EnsemblBacteria" id="AYE35341">
        <property type="protein sequence ID" value="AYE35341"/>
        <property type="gene ID" value="CP523_13395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60732">
        <property type="protein sequence ID" value="QAS60732"/>
        <property type="gene ID" value="EI377_08285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006699">
        <property type="entry name" value="GlpP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35787">
        <property type="entry name" value="PTHR35787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04309">
        <property type="entry name" value="G3P_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016897">
        <property type="entry name" value="GlpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="185" mass="20303" checksum="BFE49BC5A4DF44EF" modified="2018-12-05" version="1">MKIKELLEENPVIAAVKDLKALEVALNSESEVIFVLFGDLLNIKEISEKIAEKNKIGIVHVDLIEGINNKEVAIKFLKKETSFKGIISTKSQVVKAAKNNGFIAIQRVFVFDTLSLNNAKKHLMDECDAIEVLPGTIPKVIKKLAMEASKPIVSGGLIDTKKEIITALNSGATCVSTTKKEIWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJH7</accession>
    <name>A0A386PJH7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CP523_13730</name>
        <name evidence="13" type="ORF">EI377_08620</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677158.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02076"/>
    <dbReference type="EnsemblBacteria" id="AYE35404">
        <property type="protein sequence ID" value="AYE35404"/>
        <property type="gene ID" value="CP523_13730"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60792">
        <property type="protein sequence ID" value="QAS60792"/>
        <property type="gene ID" value="EI377_08620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362731" evidence="10">
        <location>
            <begin position="29"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS60792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="426" mass="47424" checksum="B6B471532C32FDB1" modified="2018-12-05" version="1">MKRKNVFRSLALALSISLLAPLAGRVKAEETNISNPEVTGEAAIVMDMDTNEIIYSKNADEKHSLASTTKLLTALLFAENKTKEDKIPFTEAASKQPDAALNVNYKRMNIGDTLTGEDAMESLLIFSANDAAYMIAESVAGSVENFAKLMNDRVAKLGLKNSHFINPNGIEESPTDYNYATPYDLAIIAKEAFKNEWVRNTMDVQNPPARIDITGSTFILESRNKNLGKNGNIGGKTGTETQAGHCFVGFYERDGRKLITVVLGAEYGADGTSVFKDTEKIADYGYGAEKQIYKKAGDEVSTVDLEYKVFRFFGPKKTITAPVKLTQDVMYYKNDFNDKNSKIEFLSEDKNAWKLTGGKEVSLTFSTLSHTEEVKGTVDVSAGELLKSNLPFYLAFILIIAIIIILVLVIIRIISMRKRRYRRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ3</accession>
    <name>A0A386PJJ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_07945</name>
        <name evidence="11" type="ORF">EI377_02705</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675903.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00704"/>
    <dbReference type="EnsemblBacteria" id="AYE34359">
        <property type="protein sequence ID" value="AYE34359"/>
        <property type="gene ID" value="CP523_07945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59765">
        <property type="protein sequence ID" value="QAS59765"/>
        <property type="gene ID" value="EI377_02705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07945"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="198"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS59765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="454" mass="50678" checksum="539E32410CC12C0D" modified="2018-12-05" version="1">MSKKGLKIVTIGGGSSYTPELVEGLIKRYGEMPVSEYWLVDIEEGKEKLEIVGALAKRMVEKAGVPMNIYLTLDRREALKDADFVTTQLRVGLLPARAKDERIPLSHGFLGQETNGAGGLFKALRTVPVILDIAKDIQELCPNAWLINFTNPAGIVTEALLRYGVHKKIIGVCNVPIGLHYSFAELLSVDSSRVTVDFAGLNHMVYAERVYLDGKNVTKEIIEKLTEPGGSVQTMANIKGYEWDAAFIKATGLIPCPYHRYYYKTRDMLSSELEEFKKGETRAEVVTRVEKRLFELYKDINLKEKPEELSKRGGAHYSDVACNVINSIYNDKNMIVAVNTKNNGVLKQFDNDSAIEVSCYIGKDGPKPIETITELPIFAQGLTSQIKAFERLAAEAAYTGDYNTALLAMTTNPLVADDKRGRALLNEMLLAHKKYLPQFKNVINQIEKVERAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJK8</accession>
    <name>A0A386PJK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678558.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03116"/>
    <dbReference type="EnsemblBacteria" id="AYE35677">
        <property type="protein sequence ID" value="AYE35677"/>
        <property type="gene ID" value="CP523_15250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15250"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="77" mass="8744" checksum="092C3FB55B867D83" modified="2018-12-05" version="1">MKNKLIDLNDHLFEQLERLNDEELKGEKLQEELRRAKAIVNVASQIISNANVVLKAQQFIADIDGRSKVSVPKMLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJQ7</accession>
    <name>A0A386PJQ7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15560</name>
        <name evidence="4" type="ORF">EI377_10275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00170"/>
    <dbReference type="EnsemblBacteria" id="AYE35737">
        <property type="protein sequence ID" value="AYE35737"/>
        <property type="gene ID" value="CP523_15560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61076">
        <property type="protein sequence ID" value="QAS61076"/>
        <property type="gene ID" value="EI377_10275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="32"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="277" mass="30880" checksum="BFA9173936954214" modified="2018-12-05" version="1">MKKPINKIAILHDMCGIGKAALTNVMPVLSIMGIECCPIPTLILSTHTGGFGKPVIRYNVQFIEDSINHYKENNISFDGIFIGYLGTREILRSTKKFITNFNKPKIILFDPICGDSGKLYSNFNKEYVEDLKELIKLSDIITPNFTEACLLTNKQIKTTATLEEVEEIAKDLVRLGAKNVIITSLPAKEGEIGIAIYRSDLDEFSIISHKKEKKSYPGTGDIFAAVLLGNIINGLSVEMSVEKASKFVLDCVRESNKYNYPTKEGVLLEKCLHKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJR9</accession>
    <name>A0A386PJR9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnQ</name>
        <name evidence="9" type="ORF">CP523_10865</name>
        <name evidence="10" type="ORF">EI377_05660</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677625.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34866">
        <property type="protein sequence ID" value="AYE34866"/>
        <property type="gene ID" value="CP523_10865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60261">
        <property type="protein sequence ID" value="QAS60261"/>
        <property type="gene ID" value="EI377_05660"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10865"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="423" mass="44801" checksum="A927BD15B9CEC7B7" modified="2018-12-05" version="1">MRKNTKDSIVIGFALFSMFFGAGNLIFPAFLGHTLGKDFFLGIIGFIITGVGLPLLAILACSKGDGTFETLAGKIDKKFAVLCTAILFIAIGPMLGIPRTAATTYELTIHPFFPNISPLVAMTIYFLINLFFVLRSSSVIDAIGKYLTPALLIILTIIIIKGIFMPIGEILNTNATSVLPSALLQGYQTMDAIAALLFAGIITTSLISKGYKEKQMPSMILKSSLVAVIGLAFVYGGLMYIGAQTVNLAPSDIGKTGLLLLISKSVLGNIGTTLIGVAMGLACLTTSIGLLTAGATFFEKVSKGKLSFKLNAIVLAIISLGIACLGVDKIVVLSEPILNVLYPVSITLIVTTLLSKYITNIKAVKLGVYTSLIFGLLFAIPGLNLSFIPLANIGFGWVLPTLLAICLGYIIFSTQPQINANEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS6</accession>
    <name>A0A386PJS6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_14335</name>
        <name evidence="4" type="ORF">EI377_09245</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676786.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02457"/>
    <dbReference type="EnsemblBacteria" id="AYE35514">
        <property type="protein sequence ID" value="AYE35514"/>
        <property type="gene ID" value="CP523_14335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60899">
        <property type="protein sequence ID" value="QAS60899"/>
        <property type="gene ID" value="EI377_09245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14335"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="320" mass="37989" checksum="00AE58DA67D816DD" modified="2018-12-05" version="1">MFKKLDFLYDKAKEINFDNSSKLVFISDVHRGDGTYYDAQLPNKNIYKAALYHYYKKGFTYVEVGDGDELWKNKNYSDIAYCYEDIFKLLNKFKENNRLFMLYGNHDIIKGRDSFYSKQYKSLKKCGDDYGKEFLNFIKDLKFYEAINFRYSPVDEKFLVIHGHQVDFINSQLWMISRFLVRYVWKFLNGIAGFKDPTSPARSNTRGSKVDRELLRWAKERKKMILCGHTHNSRLPGKGDPPYFNDGCCVLPYAMTAIEVENGKISLIKWSVEVQEAGVLWVRRKVIYGPLNIEEYLLWTREERNRMLREAEEIKNNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJV4</accession>
    <name>A0A386PJV4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12845</name>
        <name evidence="3" type="ORF">EI377_07715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678203.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02806"/>
    <dbReference type="EnsemblBacteria" id="AYE35238">
        <property type="protein sequence ID" value="AYE35238"/>
        <property type="gene ID" value="CP523_12845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60632">
        <property type="protein sequence ID" value="QAS60632"/>
        <property type="gene ID" value="EI377_07715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12845"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="1">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="261" mass="29890" checksum="9A1328B95AB673AA" modified="2018-12-05" version="1">MIKLIATDMDGTLLNSNNEINPEFYDVFKKLREKDIIFAAASGRQYYNLLKRFDKVKDDMLFIAENGTFVMFNGEELLVNALDKDIALELIEIGRSIENCYVIVCGKNSAYIESRDERFIKETKKYYERYEVVDDVTKVDDDILKVTICDLSGAETNSNKYFDKYRETLQVTVSGEIWLDITANGVNKGVAINKLQEKLNIKPEETMVFGDYLNDLEMMKSAYHSYAMKNAHEELKKVARFEAKSNDENGVVLAIKEAVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK36</accession>
    <name>A0A386PK36_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN</name>
        <name evidence="8 11" type="synonym">murJ</name>
        <name evidence="10" type="ORF">CP523_14810</name>
        <name evidence="11" type="ORF">EI377_09770</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676154.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01321"/>
    <dbReference type="EnsemblBacteria" id="AYE35887">
        <property type="protein sequence ID" value="AYE35887"/>
        <property type="gene ID" value="CP523_14810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60985">
        <property type="protein sequence ID" value="QAS60985"/>
        <property type="gene ID" value="EI377_09770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14810"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="150"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="157"/>
            <end position="177"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="183"/>
            <end position="206"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="246"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="287"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="398"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="424"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="463"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="511" mass="56675" checksum="0E7757D34B113B50" modified="2018-12-05" version="1">MNKNKVFKATFIVMIMTIISRFLGFGRDILAAYHFGAGETYDIYSAAVAIPDSVFMIIGLAISTTFIPMLSEVKHKKSKEEMFKLSNNIITILGILSLIVFLLGMVFTENIVNVFVPGFNSEQIQLTISLTRISLINLLFLCVNVCFLSILQVCEDFIMPSILGVFFNLPIILYLLLFNNVSILGLTIANVLGNILRVLVQIPSLYKQGYRISLFIDLNDERIKRMIILIIPVIIGAGANSLNMIVDKNLASGLVSGSISALEYSQKIIVFANTAITTSIVSVIYPVMANRLNAGDKKGFLDYLSKSIVIISLFLLPIMMAFLLLRGDIINVFYSRGAFNKEAVLLTSAALLGYSIQLPFFGIRDMLNSSLFSMQKTKVTTINGVIGVCVNILLSIILSKYIGVLGIAIATSISAAVTSILLFNSTKKIIGEFNISSMMLKLFKILISSLIMVFVLYIMNIYVNINNSLFIIIMDFFVGVLIFLGMCIILKIDELNEVLYMIKNRLIKGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK56</accession>
    <name>A0A386PK56_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13540</name>
        <name evidence="3" type="ORF">EI377_08440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677594.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00804"/>
    <dbReference type="EnsemblBacteria" id="AYE35368">
        <property type="protein sequence ID" value="AYE35368"/>
        <property type="gene ID" value="CP523_13540"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60759">
        <property type="protein sequence ID" value="QAS60759"/>
        <property type="gene ID" value="EI377_08440"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
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    </dbReference>
    <dbReference type="CDD" id="cd00077">
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="157" mass="18944" checksum="C3672D776EC9094A" modified="2018-12-05" version="1">MNRLNDILNSVEYKEYIKKIEFYEKDREFCRHDFNHFTDLARIAYIRVLENRLPYDKEIVYTIAFLHDIGRVLEYEKNIPHHKGSVIIARELLLKSNFSSLEIKLILDCIENHREGGELDLAKIIYESDKLSRNCFSCKAINKCYWDEEKKNKFIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK67</accession>
    <name>A0A386PK67_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol 2-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iolG</name>
        <name evidence="3" type="ORF">CP523_11695</name>
        <name evidence="4" type="ORF">EI377_06515</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.18" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673387.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02898"/>
    <dbReference type="EnsemblBacteria" id="AYE35026">
        <property type="protein sequence ID" value="AYE35026"/>
        <property type="gene ID" value="CP523_11695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60420">
        <property type="protein sequence ID" value="QAS60420"/>
        <property type="gene ID" value="EI377_06515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050112">
        <property type="term" value="F:inositol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030827">
        <property type="entry name" value="Myo_inos_IolG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04380">
        <property type="entry name" value="myo_inos_iolG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="333" mass="37154" checksum="E234BE7C5116D72F" modified="2018-12-05" version="1">MINIGVIGAGRIGRIHAQSIQEKVKGAQVKTIADVYRESAKKASEELRIPNYTEDYMEILNDPEIDAVIICSSTDTHSKISIEAAERGKHIFCEKPIDYDVHKIEKTLEAVRKAGIKYQVGFNRRFDHNFAKLKELINAGKIGDPNIIKITSRDPQAPPIEYVKVSGGMFLDMTIHDFDMATFLSGSRISEVYVQGACMVDPKIGEVGDVDTAIVSLKFENGCIGVIDNSREAAYGYDQRVEVFGRKGYVMADNDTDTTVRIASNDGVVEEKPKYFFLERYMDAYINEMQQFIDCLIKDKEVPVGAKEGLYSVLVGLAATKSLKEGKPIKIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK89</accession>
    <name>A0A386PK89_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engB</name>
        <name evidence="10" type="ORF">CP523_11880</name>
        <name evidence="11" type="ORF">EI377_06700</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673440.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02934"/>
    <dbReference type="EnsemblBacteria" id="AYE35056">
        <property type="protein sequence ID" value="AYE35056"/>
        <property type="gene ID" value="CP523_11880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62169">
        <property type="protein sequence ID" value="QAS62169"/>
        <property type="gene ID" value="EI377_06700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS62169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="206" mass="23540" checksum="3D2627B094EECD44" modified="2018-12-05" version="1">MKINNSEFIISAVKRNQYPDTGLPEVAFVGRSNVGKSSIINALTNRRKLAKVSQTPGKTRLINFFMINNGEFYLVDLPGYGYAKVSKKEQASWGNTVETYLTGRDPLKRVILLVDSRHKPTSDDIQMHQWIKHFGYDEIIVATKSDKLSNNELRKSEKVIRQTLELDSSDKLYFFSSLNKKGKDQLVENLFGDLVYKEEIEGNVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKK8</accession>
    <name>A0A386PKK8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35292">
        <property type="protein sequence ID" value="AYE35292"/>
        <property type="gene ID" value="CP523_13135"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13135"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="265" mass="30950" checksum="7671EFEC35C1F1E5" modified="2018-12-05" version="1">MKHFLSFGGGVNSVALYLYMIEQGIEFEAVFSNHGADHPDTYRYMDYFNKEVIKRGWKPVTIVEGNVKERNMNKGLDLFHYCLEKSVVPSRMLRWCTEKFKIIPTNLYINSKLEGGEDEKCYMHLGIAYDEANRARPPQNPPKYLANKIFKYLFVEDGITRKENIEIIERHGFKVPRKSGCYFCPYAKKAEFIELYRNDPCLYEKARALEHKVNEKRVSDNKKPLYISSKPIEVIVGEGQIEMFFDDYGLLDHIGERERPCNCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKR0</accession>
    <name>A0A386PKR0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13510</name>
        <name evidence="3" type="ORF">EI377_08410</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677586.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00798"/>
    <dbReference type="EnsemblBacteria" id="AYE35362">
        <property type="protein sequence ID" value="AYE35362"/>
        <property type="gene ID" value="CP523_13510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60753">
        <property type="protein sequence ID" value="QAS60753"/>
        <property type="gene ID" value="EI377_08410"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13510"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006485">
        <property type="entry name" value="Phage_holin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04531">
        <property type="entry name" value="Phage_holin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="89" mass="10035" checksum="C8B18BDB94E9476E" modified="2018-12-05" version="1">MKNFDWSRFKNYGLWVSIISLIPLILNAFGVKVVAPEYQTATNAILSILVALGIVNNPTTCNKWFKDDGVIKEPEPKAIDGNKEEKIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKR6</accession>
    <name>A0A386PKR6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10880</name>
        <name evidence="4" type="ORF">EI377_05675</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677631.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02510"/>
    <dbReference type="EnsemblBacteria" id="AYE34869">
        <property type="protein sequence ID" value="AYE34869"/>
        <property type="gene ID" value="CP523_10880"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60264">
        <property type="protein sequence ID" value="QAS60264"/>
        <property type="gene ID" value="EI377_05675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10880"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="250" mass="29280" checksum="E8A27EAADB120966" modified="2018-12-05" version="1">MEKELLVIVPAYNEEDNIKNVIEELKKDVPYANILVVNDSSTDKTEEILKNMNVDYITTPFNLRYSGVIQTGFKYALFRNYNYVAQFDGDGQHIAKELDKMFKYIKQNDCDIVLGSRFKEKTEYNHAFFRKIGTIMFQKIIKISTRKEITDPTSGLQVLSKRVYTHYAKMNNYPEYPDANLIIEMLNEGYNIQEVYVKMRERIYGISMHSGIWSPIKYMISMCYSIFIILIGKKSNNTYKNYNEACGEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL15</accession>
    <name>A0A386PL15_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15465</name>
        <name evidence="2" type="ORF">EI377_10170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678724.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35718">
        <property type="protein sequence ID" value="AYE35718"/>
        <property type="gene ID" value="CP523_15465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61058">
        <property type="protein sequence ID" value="QAS61058"/>
        <property type="gene ID" value="EI377_10170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="104" mass="12018" checksum="8327927750554094" modified="2018-12-05" version="1">MKKFIWTILIIFTLSSTCFFKPVYAINLFKEGIYKVSDFNPPQEDKYTVQNSSSENSVLIQVYNNNLLLIQSIKLIPSSEKYKLIELLPDYKIVIIGDGEVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLG9</accession>
    <name>A0A386PLG9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_15535</name>
        <name evidence="6" type="ORF">EI377_10245</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678701.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00175"/>
    <dbReference type="EnsemblBacteria" id="AYE35732">
        <property type="protein sequence ID" value="AYE35732"/>
        <property type="gene ID" value="CP523_15535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61071">
        <property type="protein sequence ID" value="QAS61071"/>
        <property type="gene ID" value="EI377_10245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="298" mass="34356" checksum="83DB478B630BF361" modified="2018-12-05" version="1">MLKVNNLSLKLGDKKILEDINFNVKKGTILGLVGPSGVGKTSLIKALVGIYEGNGGEILLNEEKIYDNSEVKKKIAYVPDEHNSFYLISIKEIVNYYKLIYDNFDENRFNKINSIFKIPINKRFFQLSKGMKVRVNLMLALSLNGELLVLDEPTSGLDPILKEKVLKLIMEEVIDKERVIIISSHNLIELERICDDIIMLDEGKIAYHNSLEGIKKNIKKIQVAFDMPVYKEDLNIDGIFSISQIGRVFTIVTDKYDNIFKEKLEEFNPLFIEEIDLSLEEVFIHKLEKEDDYEEIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLM4</accession>
    <name>A0A386PLM4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_13545</name>
        <name evidence="6" type="ORF">EI377_08445</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35369">
        <property type="protein sequence ID" value="AYE35369"/>
        <property type="gene ID" value="CP523_13545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60760">
        <property type="protein sequence ID" value="QAS60760"/>
        <property type="gene ID" value="EI377_08445"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="340" mass="38819" checksum="5DECA1BF4D05EE06" modified="2018-12-05" version="1">MSKTNIKCPRYNSDKLYKFGMNKQAKQKYQCKQCKRQFVLGDGDGRPKLNNPKCPRCGKGTYLHHAYKHYNRYKCNNKKCNHIIVKHHTTNIDTASSELVSGSLSMKGMRFPLHVILTALTLYFLNNSSTRAISQFLMINAGIKVSHVTIASWTNKFAPFFKQKADKFKASLNLQSDDWHADETVVFINGERYYLWLAIDSETRFILAFHLTKSRSSDSAYTLVNEAKKFGEPANFITDRLPSYNEAVATLLPNTTHIPVAPMSSDTNNNLIESFNKTFKAWYKTKKGFNSFQKANNLIYLFIFHYNFIRPHGSLNNCTPAEVAGFASDSFAKNSWFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM61</accession>
    <name>A0A386PM61_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15470</name>
        <name evidence="2" type="ORF">EI377_10175</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678722.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35719">
        <property type="protein sequence ID" value="AYE35719"/>
        <property type="gene ID" value="CP523_15470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61059">
        <property type="protein sequence ID" value="QAS61059"/>
        <property type="gene ID" value="EI377_10175"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046117">
        <property type="entry name" value="DUF6054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19524">
        <property type="entry name" value="DUF6054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="112" mass="12459" checksum="7C5850166EE645F0" modified="2018-12-05" version="1">MGADDFRVNLSLKETIRRLDSGIVDGSFTGERIDYYVVMGNDENGVIVLVYEKHFQRAGNRLTLTVTVDNMNGFTKIHSIAAGGGQGLFRFDWGAGEKFTCAPRRVLEDNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PAU9</accession>
    <name>A0A386PAU9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_00650</name>
        <name evidence="14" type="ORF">EI377_11140</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676367.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00661"/>
    <dbReference type="EnsemblBacteria" id="AYE33063">
        <property type="protein sequence ID" value="AYE33063"/>
        <property type="gene ID" value="CP523_00650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61232">
        <property type="protein sequence ID" value="QAS61232"/>
        <property type="gene ID" value="EI377_11140"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00650"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="181"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS61232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="35573" checksum="C8A4F61AB704BD70" modified="2018-12-05" version="1">MIVLEDSFIKEKHKANYVALGSFDGLHLGHLSLVRKAVEIANKNGGNSMVFTYKNHPKTLIKPEFAPKLIMDMDTKLEILEREKIDIVAIKSFTKEFMKMSSEDFIKFLCINYNVKGIIVGFNFKFGYKNQGDINILRDLQQKYKYQLYVIEAFRYKDEIISSTRIRESILNGEVLEAREMLSKPFKLKGLVTHGKKLGRTIGFPTANIKFDSKIIIPKIGVYYTNIIYNDKKYKGITSVGNNPTVNGKELTIETYILDFNSEIYDEEIEVYFIDRIRDEKKFSSVDELVIQLKKDKKFADRSGFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PC28</accession>
    <name>A0A386PC28_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="1">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">birA</name>
        <name evidence="3" type="ORF">CP523_02010</name>
        <name evidence="4" type="ORF">EI377_12530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678892.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00130"/>
    <dbReference type="EnsemblBacteria" id="AYE33320">
        <property type="protein sequence ID" value="AYE33320"/>
        <property type="gene ID" value="CP523_02010"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61490">
        <property type="protein sequence ID" value="QAS61490"/>
        <property type="gene ID" value="EI377_12530"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02010"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="66"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="1">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="1">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="326" mass="36757" checksum="847F7754D2A9A615" modified="2018-12-05" version="1">MKEKVLMLLKNSSDFLSGEKISNKLGITRASVWKHINVLKKEGYIIEGISNKGYRLISSYDILNPLEIKEKLQTKYIGKDIKYFETIDSTNIMAKKLANNDAIDGTLIISEVQSFGRGRLNRQWISPKGGIWASLILKPNLEPIQAPKITLIAAAALILTFKKYNLDVKVKWPNDILLKNKKISGILTEMNCDMDRINYIILGFGINVNLKEDTIPKDLRNKATSLLLSTGKTFSRIDLLCKFLKEFEKLYHELLNENHADTSISICKENSILIGKDIIISSLNLNEKVKCIDLTKDGSLLVQNSSGKIKKVFSGEISLFENYANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCC4</accession>
    <name>A0A386PCC4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03545</name>
        <name evidence="9" type="ORF">EI377_14070</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677933.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02260"/>
    <dbReference type="EnsemblBacteria" id="AYE33605">
        <property type="protein sequence ID" value="AYE33605"/>
        <property type="gene ID" value="CP523_03545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61769">
        <property type="protein sequence ID" value="QAS61769"/>
        <property type="gene ID" value="EI377_14070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="555"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="770" mass="89598" checksum="CC17272870E92906" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCD3</accession>
    <name>A0A386PCD3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein Hfq</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">hfq</name>
        <name evidence="2" type="ORF">CP523_00160</name>
        <name evidence="3" type="ORF">EI377_10735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hfq family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677398.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01200"/>
    <dbReference type="EnsemblBacteria" id="AYE32974">
        <property type="protein sequence ID" value="AYE32974"/>
        <property type="gene ID" value="CP523_00160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61158">
        <property type="protein sequence ID" value="QAS61158"/>
        <property type="gene ID" value="EI377_10735"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01716">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00436">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34772">
        <property type="entry name" value="PTHR34772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02383">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="76" mass="8467" checksum="40D507B8B5B6D67A" modified="2018-12-05" version="1">MNKGVNNLQDIFLNGARKNKIPVTIYLSNGFQLKGFVKGFDSFTVVLDSDGKQMLIYKHAITTITPGKSILFNESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCG9</accession>
    <name>A0A386PCG9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Insulinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Peptidase M16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_00395</name>
        <name evidence="4" type="ORF">EI377_10885</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00590"/>
    <dbReference type="EnsemblBacteria" id="AYE33014">
        <property type="protein sequence ID" value="AYE33014"/>
        <property type="gene ID" value="CP523_00395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61183">
        <property type="protein sequence ID" value="QAS61183"/>
        <property type="gene ID" value="EI377_10885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="16"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="163"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="405" mass="47275" checksum="7A436867EE0EF2ED" modified="2018-12-05" version="1">MVEYILKNNIKLVYKKTTSSLTSISISLGAGAAMDGKKLGIAHATEHMVYKGTKNRSEAEINRELSDIFGFQNAMTNYPYVIYYGTLLNDDFKAGISLFKDILVNPEFKEDGFNEEMQVIIEELKEWDEELDQYIEDKLFLNSFSNRRLKNPIIGKLSTLKEMTLKDIRNFYNKYYVPSNTSIAVISSLNFDYVKKVIEEEFNSWEDKKLLKEKELYESPKCEIFYNYREGIKTCKVEIIYSIHNLTEKELKALTIFDEYFGKGVNSILYDTLRTKNGLIYDVLTKISLESHIKLYKINFSTSKENLDYSLKLINDCIDNIVNLKDMLTEEDKKRLIKGIKLKRLFREEQNIILAKELSTYGTMFNDFNRYLDEINNLEDMEIDFIIDVAIKVLKKPSIEIILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCM6</accession>
    <name>A0A386PCM6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rseP</name>
        <name evidence="12" type="ORF">CP523_00705</name>
        <name evidence="13" type="ORF">EI377_11195</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676389.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00672"/>
    <dbReference type="EnsemblBacteria" id="AYE33074">
        <property type="protein sequence ID" value="AYE33074"/>
        <property type="gene ID" value="CP523_00705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61243">
        <property type="protein sequence ID" value="QAS61243"/>
        <property type="gene ID" value="EI377_11195"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00705"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="10">
        <location>
            <begin position="6"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="339" mass="37501" checksum="1F4C2A687D90CE9D" modified="2018-12-05" version="1">MYIIFALLGFSLLIIVHELGHFIMAKANGIKVEEFAIGMGPKIFKTQGKETTYSIGLLPIGGYVKMMGEEEDVQDERSFSAKSPLRRISVIVAGAAMNFLLAIFIFTIYLSKAGYALPEVSNITDKSPAYEAGLQVGDKFLKADESRILSADDIRVAINMAKNNPVNFLIERNGEKKEISITPELVKENEIESYRIGFSFVVKENPTMFESFKQSFNKTATAVVQTFKGLKMLVTGEANLKTDVGGPVTIIRMTGVAAQNGIWNLMHFIAFISVNLAVFNMLPIPALDGGWTIILLIELITKRKVPDRIVGTINYIGMIALFGLMILVTIKDILFPIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCP8</accession>
    <name>A0A386PCP8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multidrug ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04230</name>
        <name evidence="6" type="ORF">EI377_14755</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33735">
        <property type="protein sequence ID" value="AYE33735"/>
        <property type="gene ID" value="CP523_04230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61892">
        <property type="protein sequence ID" value="QAS61892"/>
        <property type="gene ID" value="EI377_14755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04230"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="33270" checksum="3B50EACDFDD64C5A" modified="2018-12-05" version="1">MNNIEIKNISKSYGNKTVLDNISLTIEEGKIYGLLGCNGAGKTTLLNAITNRTFIDKGEILINGQNIYENDNAISKVYYMTEKNLIPDDMKINDIFKYTKDFYPNFDIEYANILSNKFKLNTNKRIKELSTGYRSICKLITCLSSGANFLFFDEPVLGLDAKHRDMFYKELLSLYTEKQNTIIISTHIIEEISDLLERVIILNNSKIIENENVEDLLSRAYAVSGKDNLIDKYIVDKNVIAIDVLGSFKKATILQEKTKEDLNYIKELQLEVNKVELQKLFINLTDKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDG2</accession>
    <name>A0A386PDG2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_04755</name>
        <name evidence="6" type="ORF">EI377_15265</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675797.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01721"/>
    <dbReference type="EnsemblBacteria" id="AYE33830">
        <property type="protein sequence ID" value="AYE33830"/>
        <property type="gene ID" value="CP523_04755"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61976">
        <property type="protein sequence ID" value="QAS61976"/>
        <property type="gene ID" value="EI377_15265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04755"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="28939" checksum="F1D4D52FE895731F" modified="2018-12-05" version="1">MIERILEVKNLKKYYGKKDFETKALDGISFQVMNGEFIGIMGSSGSGKTTLLNCIATTTHPTEGNILLKGERIEDFKGNKLADYRGNKIGYLFQNFELLENLTAKENILLPMAIHNKLKKNSNIELEKLAEYMEITDVLDKFPNEISGGQKQRVAAARALILNPQIILADEPTGALDSKNAKALMQKLSDLNEDEKTTILMVTHDANVASFCSRILFIQDGKLFHELRRKKPEESRQDFYERILLVMAQLGGGSANVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDH8</accession>
    <name>A0A386PDH8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">murQ</name>
        <name evidence="5" type="ORF">CP523_06005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01903"/>
    <dbReference type="EnsemblBacteria" id="AYE34053">
        <property type="protein sequence ID" value="AYE34053"/>
        <property type="gene ID" value="CP523_06005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06005"/>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="57"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="301" mass="32602" checksum="BB71A7AD62200D8C" modified="2018-12-05" version="1">MKINLTRLDTEKINDNSKNIDKLSTIDMLKVINEEDKKVAIAVEKVLPNIALIVDETYKRIKNGGRLIYIGAGTSGRLGVLDASECPPTYGVDFELVQGIMAGGQSAIFKAKEGAEDSKELAVDDLKDINLNENDIVIGLAASGRTPYVIGGLEYANEIGAGTGSICCVQNAEISKVAKLPVEVIVGAEVVTGSTRMKSGTAQKLILNMISTGTMIKLGKVYGNLMIDVRPTNEKLVERSKNIIINCTGVSREIATEIFEKSGRDVRVAIFMALTNLNREESIKLLEENENNISKALEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDM6</accession>
    <name>A0A386PDM6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgC</name>
        <name evidence="8" type="ORF">CP523_02625</name>
        <name evidence="9" type="ORF">EI377_13160</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673900.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00442"/>
    <dbReference type="EnsemblBacteria" id="AYE33434">
        <property type="protein sequence ID" value="AYE33434"/>
        <property type="gene ID" value="CP523_02625"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61608">
        <property type="protein sequence ID" value="QAS61608"/>
        <property type="gene ID" value="EI377_13160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="134" mass="14691" checksum="796EDE83AA99CF9C" modified="2018-12-05" version="1">MSLFNTMRISASGLSAERLRMDTITSNSTNVNTTRGKDGKPYVRKIAVFQENLDNAMGLNGVKAVGVVEDKSPLRKVYNPSHPDADNDGYVTMPNVNILNEMADMIASSRAYEANVDTLNATKNMFTKTLEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDQ3</accession>
    <name>A0A386PDQ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03505</name>
        <name evidence="8" type="ORF">EI377_14030</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677916.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02252"/>
    <dbReference type="EnsemblBacteria" id="AYE33597">
        <property type="protein sequence ID" value="AYE33597"/>
        <property type="gene ID" value="CP523_03505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61761">
        <property type="protein sequence ID" value="QAS61761"/>
        <property type="gene ID" value="EI377_14030"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="311" mass="32176" checksum="66FA6C482CC91975" modified="2018-12-05" version="1">MKESIKVNLTKYKSLIGLVALCIIISIITPRFLTVTNITNVLTQISVNAIIAVGMTFVILTGGIDLSVGSTLALSGAFAASIIKSTGNIWLAIIVAIIIGSIIGLVNGALVSKGKLQAFIATLATMTIFRGATLVFTNGTPISKLPESFMKIGNGKIGVLPIAVLITIIVAVIAMYMLSQTRFGRYLYAVGGNEDSARLSGINTNKIKTLVYVLSGIAAAISGVIITSRIGSASPNAGSGFELDAIAAVVIGGTSLAGGEGKISGTIIGALIIGVLNNGLNLMNVSPFYQSIVKGLVILIAVLLDKRDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDS1</accession>
    <name>A0A386PDS1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="14" type="ORF">CP523_01160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674400.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02286"/>
    <dbReference type="EnsemblBacteria" id="AYE33161">
        <property type="protein sequence ID" value="AYE33161"/>
        <property type="gene ID" value="CP523_01160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="13">
        <location>
            <begin position="4"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="706"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="879" mass="98404" checksum="C45C01E49B8374D7" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDY3</accession>
    <name>A0A386PDY3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07090</name>
        <name evidence="3" type="ORF">EI377_01835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673700.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01033"/>
    <dbReference type="EnsemblBacteria" id="AYE34235">
        <property type="protein sequence ID" value="AYE34235"/>
        <property type="gene ID" value="CP523_07090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59640">
        <property type="protein sequence ID" value="QAS59640"/>
        <property type="gene ID" value="EI377_01835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="1">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="114" mass="11723" checksum="BB96ECEC0E2328DC" modified="2018-12-05" version="1">MKKLGAILASTVLAATLLVGCGGGKYVDGTYTGEGKGNAGSIKVEVKVEKGNISDIKLVESHETQTLVDGVKESMFPDIIKKQGTEDVEAISGATNSSKGALQAVNDALKQATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEE6</accession>
    <name>A0A386PEE6_CLOSE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04735</name>
        <name evidence="2" type="ORF">EI377_15245</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33827">
        <property type="protein sequence ID" value="AYE33827"/>
        <property type="gene ID" value="CP523_04735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61973">
        <property type="protein sequence ID" value="QAS61973"/>
        <property type="gene ID" value="EI377_15245"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="39" mass="4769" checksum="95147AADEF0BE5E0" modified="2018-12-05" version="1">MKNKDINLYDIFTRYSYNDIMKLLESSKSKEEKDFYANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEM2</accession>
    <name>A0A386PEM2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02870</name>
        <name evidence="2" type="ORF">EI377_13395</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677006.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00980"/>
    <dbReference type="EnsemblBacteria" id="AYE33481">
        <property type="protein sequence ID" value="AYE33481"/>
        <property type="gene ID" value="CP523_02870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61652">
        <property type="protein sequence ID" value="QAS61652"/>
        <property type="gene ID" value="EI377_13395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="132" mass="15722" checksum="03AA05CF39D32DD2" modified="2018-12-05" version="1">MDFSSLVLMEKDKETGFITKELGSFEVSEGALYVKKLFVLDNIINLYFDTNKDVEEWEYSAIYDLFNYKVFEENGFTVEDVLDEYNPTFMIRFDYNEDYAVIKEKLDKCVKLIEESMEKVFKDILGKEQEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP0</accession>
    <name>A0A386PEP0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium channel protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Potassium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_02105</name>
        <name evidence="11" type="ORF">EI377_12625</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00545"/>
    <dbReference type="EnsemblBacteria" id="AYE33338">
        <property type="protein sequence ID" value="AYE33338"/>
        <property type="gene ID" value="CP523_02105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61508">
        <property type="protein sequence ID" value="QAS61508"/>
        <property type="gene ID" value="EI377_12625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02105"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="PTHR11537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="9">
        <location>
            <begin position="136"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="29293" checksum="09CCD4C827090F5D" modified="2018-12-05" version="1">MTKKEIYNDFIGLISLMASIMLMFQITIDLPYEVLISFYYIDSIVWIIFILDYVLGLILAKRKINYIKTHIIDIMVIITVKTYLRFFKALNITLILNNAIIIKFAEFIRLVILILKFKKSIKKSKKLNRFNYMLILTTIVIVLGAVIISLLEGMSFEDALWWSFVTFTTVGYGDVLLTTSMGRVVAVLLMIFGIGFIGITTSTIAAYIINGGRKKRNMDFKQQTIENIKYKLDNLDKLSDSELEDIYKTLKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP3</accession>
    <name>A0A386PEP3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">disA</name>
        <name evidence="12" type="ORF">CP523_08835</name>
        <name evidence="13" type="ORF">EI377_03590</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678104.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02707"/>
    <dbReference type="EnsemblBacteria" id="AYE34515">
        <property type="protein sequence ID" value="AYE34515"/>
        <property type="gene ID" value="CP523_08835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59917">
        <property type="protein sequence ID" value="QAS59917"/>
        <property type="gene ID" value="EI377_03590"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08835"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="354" mass="40083" checksum="E60CE43F89E0BFD1" modified="2018-12-05" version="1">MRIKDDKEIKKILKLMSPGTPLRDGLENILRAKTGGLIVIGDGEAVMELVDGGFHINSEYTPAYVYELAKMDGAIVISGDLKRIVCANTQLVPSSSLTTYETGTRHRTANRVAKQTGNIVIAISQRRNIITIYKGELKYVLQESSVILARANQAIQTLEKYVIVLNRAINNLNLLEFQDLTTLFDVVTAIQRTEMVMRIVEEIKRYIVELGNEGRLISMQLHELIKNIERDGILLIRDYCKEDLEPEEIYKDIQVFSAEELLDLDLIAKLLGYNGISLVDTLISPKGYRVLFKVPRIPSVVIENLVKHFNELKYVVEANTDDLDQVDGIGEARARAIRNGLRRIKEQVYLKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEP7</accession>
    <name>A0A386PEP7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678936.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32962">
        <property type="protein sequence ID" value="AYE32962"/>
        <property type="gene ID" value="CP523_00100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE32962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="65" mass="7204" checksum="3C13D74A5998B14A" modified="2018-12-05" version="1">MKKLSEAENLSLSAILKMEKNALIMQKAIGSLISDEDLKRQSEASILATEGRIKGIQKFIEDNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER2</accession>
    <name>A0A386PER2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GntR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04225</name>
        <name evidence="3" type="ORF">EI377_14750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676507.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33734">
        <property type="protein sequence ID" value="AYE33734"/>
        <property type="gene ID" value="CP523_04225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61891">
        <property type="protein sequence ID" value="QAS61891"/>
        <property type="gene ID" value="EI377_14750"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="123" mass="13813" checksum="2A23A765A8A1B5AA" modified="2018-12-05" version="1">MVFNFNEDSPIYLQIANSIEDGILNGIYQEESQIPSTTEISITYKINPATVGKGFNILVNEGIIYKKRGVGMFVSTGAVKKLLTNRKNKFFDNYILTLMSEAKRLGITVDEIINMIKGGNYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV6</accession>
    <name>A0A386PEV6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flgG</name>
        <name evidence="5" type="ORF">CP523_02490</name>
        <name evidence="6" type="ORF">EI377_13025</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673950.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00469"/>
    <dbReference type="EnsemblBacteria" id="AYE33408">
        <property type="protein sequence ID" value="AYE33408"/>
        <property type="gene ID" value="CP523_02490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61582">
        <property type="protein sequence ID" value="QAS61582"/>
        <property type="gene ID" value="EI377_13025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="185"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="257" mass="28529" checksum="E7F8F670516BC438" modified="2018-12-05" version="1">MLRTLWTGKSGMISNQERLDVISNNLANSTTVGYKKVEIGFRDLLMESLDRKGVPLNNKESEIGTGVRTSDWFRNDSQGNLLATTKPTDVAIDGNGYFKIIAPDGEIAYTRDGALSIDGYNRLVDNRGNKLEINFLPGFSEDNVKFTKDNFVIDKSGQLFINEQGTLKQVGEIPLYTAVGDKAFMSIGDNLFKPMPGSEVIRASDFNLYQGKLEASNVDIATEFADMIITQRAFELNSRGVKTADEMWGMVNNLRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEV7</accession>
    <name>A0A386PEV7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07805</name>
        <name evidence="4" type="ORF">EI377_02495</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679161.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02106"/>
    <dbReference type="EnsemblBacteria" id="AYE34340">
        <property type="protein sequence ID" value="AYE34340"/>
        <property type="gene ID" value="CP523_07805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59736">
        <property type="protein sequence ID" value="QAS59736"/>
        <property type="gene ID" value="EI377_02495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="387"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="470" mass="53124" checksum="007A8301DCA09A05" modified="2018-12-05" version="1">MDYDILILGGGIIGCSVAYELSKYNFNIAVIEKDYDIADDISFVNTSIVYDGSETSDNVMAGLEYIGNSILEETCKKFNVPFKRIGALRVVNDENGVRKLEEMHSRAKYRGIEGVTLIDAEQVYKIEPNINTNIKKGLYSENVAIVAPYDLAIAYAEVASDNGVNFRLEEEVLNIKNLAKGFKVTTNKNKFSCKVVINTIPNEMYIQENGIVEEKDSEISENEFKNMSYLLVANNYKNKLKKIVIETLDKNTFVVSTPTTTTGSLIGIKSINKTSLDDNLDYVNNLLIGLEKKHINNLFRESYDKDSILIDDSEIDRGYIRVTGTHYGKITMAPAIAKMLCDTLTNNLKCTLKKNFLDKRRYFYKFREMDKDELNEVISLDKRYGKIICVCNNISEGEIVDCIRRPLGARTVEGVKRRTGAGFGSCHGSYCYDKIINILARELDKKVTDIVDDSKESKIISGRIKEFDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW9</accession>
    <name>A0A386PEW9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MurR/RpiR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07885</name>
        <name evidence="4" type="ORF">EI377_02575</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675864.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00680"/>
    <dbReference type="EnsemblBacteria" id="AYE34350">
        <property type="protein sequence ID" value="AYE34350"/>
        <property type="gene ID" value="CP523_07885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59747">
        <property type="protein sequence ID" value="QAS59747"/>
        <property type="gene ID" value="EI377_02575"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07885"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="105"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="248" mass="28743" checksum="B524D72DB005B892" modified="2018-12-05" version="1">MFTYQQIESLNDLELQVYDYIIKNQHTVLKLTIRELAQKVHVSTTTILRFCKKMGCDGFFEFKYKLKEHLTETSKPFKLHINDYAAIDYFKRSNHPSELQKIIDASKIINKSKQIIFLGIGTSGILAKYASRCFINIGKFAVYIDYPYFLVPDGFYDETVIIVFSVSGETEDIINQIRQFRKFNCVVISITNSEISTIAKLSDLVISYYFPLQIKGENKINLTSQIPVMNIIEKLTFYLSQSECIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY6</accession>
    <name>A0A386PEY6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_02645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673892.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00438"/>
    <dbReference type="EnsemblBacteria" id="AYE33438">
        <property type="protein sequence ID" value="AYE33438"/>
        <property type="gene ID" value="CP523_02645"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="301"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="387" mass="42135" checksum="FD014D82056FF91B" modified="2018-12-05" version="1">MIINHNMNAMNAHRNMASNTVATGKSMEKLSSGLRINRAGDDAAGLSISEKMRGQIRGLEQASRNSQDGISLIQTTEGALNETHSILQRMRELSVQASNDTNTAEDRGQLTKELDQLRSEIDRISSQTQFNKMDVLNGDGDKSFKANIQVGANSNQAIEIAIEKMDYSSLFKAHKVASTDEVAGDITVKATKDIKVTIDTKEITIKADPKVDKTLTKEELVAEINKGIEAEATLKGKVSASFEDNKLTISRIDGEDKEVTVKVEDNNADGNTKLGIAGDTKSKMEVFNVDLTSHAAATGSISAIDRAIEKVSTQRSQLGAYQNRLEHTIKNVDNAAENLQAAESRVRDVDMANEMMTFSKNNILTQAAQAMLAQANQQPQGVLQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF08</accession>
    <name>A0A386PF08_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase III PolC-type</fullName>
            <shortName evidence="11">PolIII</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 16" type="primary">polC</name>
        <name evidence="16" type="ORF">CP523_00695</name>
        <name evidence="17" type="ORF">EI377_11185</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676385.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00670"/>
    <dbReference type="EnsemblBacteria" id="AYE33072">
        <property type="protein sequence ID" value="AYE33072"/>
        <property type="gene ID" value="CP523_00695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61241">
        <property type="protein sequence ID" value="QAS61241"/>
        <property type="gene ID" value="EI377_11185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00695"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024754">
        <property type="entry name" value="DNA_PolC-like_N_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11490">
        <property type="entry name" value="DNA_pol3_a_NII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01405">
        <property type="entry name" value="polC_Gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 11 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="15">
        <location>
            <begin position="343"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="14">
        <location>
            <begin position="427"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1441" mass="162486" checksum="4D644D08615FAAE2" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF44</accession>
    <name>A0A386PF44_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06025</name>
        <name evidence="2" type="ORF">EI377_00505</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34057">
        <property type="protein sequence ID" value="AYE34057"/>
        <property type="gene ID" value="CP523_06025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59428">
        <property type="protein sequence ID" value="QAS59428"/>
        <property type="gene ID" value="EI377_00505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="256" mass="29449" checksum="BF2240456D283E62" modified="2018-12-05" version="1">MSKKILGLIIIGLLSLNIVGCGIKKEVSETEQGINYNSYIPKAGESLENKIILPKDINIDNNYEIVDLEGRNNAISKNYLEGLKVVKAFSSENSIDLKNTKFINDVLTESSENEEIKKLLSRLDNVEAMQYFSENEGINVDLSINIQPARLKEYSSVGAFTFADVTYKASIENIDKNFKFKGSKLDDFRGKILKSRSEAYVDNLDYDTIDKYVSGYFHGKYDKYIIFFNRLDENSYERIKIDNNNIYYKFIYDPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF75</accession>
    <name>A0A386PF75_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34087">
        <property type="protein sequence ID" value="AYE34087"/>
        <property type="gene ID" value="CP523_06180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06180"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031639">
        <property type="term" value="P:plasminogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036120">
        <property type="entry name" value="SAK/SK_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54328">
        <property type="entry name" value="SSF54328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0617">Plasminogen activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017275768" evidence="3">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="322" mass="36997" checksum="8EE5AF2077E3172B" modified="2018-12-05" version="1">MLKLQKPIFVLMFSLFLLFFKGNITNAEDFKVSSGNKEQTTLLSISVNGVDSKTNKEILFIPFVDLSVQPGGTLKYSRVIEIIQESVNEIAGYNKFKVEGFSDNVELREGFSETYIKLKNNEDIHLPKIDGLNNDEVYAINGDVIISEYPKLEIPSDLEYDIKVVYSAFFYEKLEDGGYKRLSFFHEEDLEGFTTDSKLDSKQLQYLAQKALDNRFGINQYKITSRRIAVARNMTQSIYNNYQGEILSGFETNDQFTYTIKPQIKDPKVSEYLTCINDNFYVEKVNSENNEETTINPDFNENNYTIDTSTSELSLSIFLCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC7</accession>
    <name>A0A386PFC7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03405</name>
        <name evidence="2" type="ORF">EI377_13930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679099.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000064.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00058"/>
    <dbReference type="EnsemblBacteria" id="AYE33578">
        <property type="protein sequence ID" value="AYE33578"/>
        <property type="gene ID" value="CP523_03405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61742">
        <property type="protein sequence ID" value="QAS61742"/>
        <property type="gene ID" value="EI377_13930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03405"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="24561" checksum="0267B84D23CAD613" modified="2018-12-05" version="1">MKVFDLSHEITRSMTVYSEKERPNFNKVSSIEEAGYNETNINIYSHNGTHMDSPYHIFKEGKKLSEFPVENFLGNAFILDVTKNKENEITLEFLKLYQEEIKKSEFLILKTGWEKYWNNEKYFNDFPVLSEEAALWLSMLNIKGIGVDTISVDKVHSKDFNIHKILLSKEKIIIENLTNLNNLYGKFMFIATPLNFKESDGCPVRAIGIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFD9</accession>
    <name>A0A386PFD9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiE</name>
        <name evidence="3" type="ORF">CP523_01475</name>
        <name evidence="4" type="ORF">EI377_11995</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675625.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00847"/>
    <dbReference type="EnsemblBacteria" id="AYE33222">
        <property type="protein sequence ID" value="AYE33222"/>
        <property type="gene ID" value="CP523_01475"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61394">
        <property type="protein sequence ID" value="QAS61394"/>
        <property type="gene ID" value="EI377_11995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01475"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="200" mass="22632" checksum="05184786F5FCEBB9" modified="2018-12-05" version="1">MIYIVGLGPGNIEYIMPKAVTILKKSKIILGFSRAIDSLDFIENKKRKVKTLREIIDFIKESKEEDISVVASGDPTFYGISDYIGKNYKGDLKVIPGLSSFQYLTCKVNKSWSNAYTGSLHGREDDFIKKVKENSVSIWLTDNKNTPNSLCKSLIENNVSSKVIVGENLSYEDERIFYDTPNNLLEKEFSNLSIVIVEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFJ4</accession>
    <name>A0A386PFJ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Rne/Rng family ribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_10645</name>
        <name evidence="8" type="ORF">EI377_05430</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674149.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01373"/>
    <dbReference type="EnsemblBacteria" id="AYE34823">
        <property type="protein sequence ID" value="AYE34823"/>
        <property type="gene ID" value="CP523_10645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60218">
        <property type="protein sequence ID" value="QAS60218"/>
        <property type="gene ID" value="EI377_05430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="482" mass="55871" checksum="FA4A66C456B7440E" modified="2018-12-05" version="1">MKKIFIERKRNLLRIAIQDKGRLSECFVEEYSLDPQIGEIYKGRVKNIVPAINSIFVDIGLSKEGYMYLSNELKGKGIKKGDEILVEVVKEPLNNKGAKLTSKVSVSGKFMVITLGGSGISFSKRITDYKEINRLKDFITPLDGYELLLRTNSVNATKNQLEEEQKALIEKIDCIKRKLFYSLKLGKVYGENIILNKVLRDKVDDEAEIIVDNEDDYNQVMEYFKNNEDIKIFLFNENRGLFHYYDIEKEILKLRHNKVNLPCGGNIVIDKTEAMYVIDVNSGKNIKGRSFEKTILETNVEAANEIGRQIRLRNLSGIIVIDFIDVRNKLHKAIIMDELKKSLSPDKGNVRIFPFTELDLVQISRKRIGKSIYNYLDESCKRCKGQGEVLKISYIENLLENEIIKCNEENSINDFYIELDKNYQEEIEGNMFNFLRNIQGLDKEIYLNFVDGIEGYKIEPLIFNTQKENVKKFKVNAYEKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFL5</accession>
    <name>A0A386PFL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_07040</name>
        <name evidence="6" type="ORF">EI377_01785</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673684.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01024"/>
    <dbReference type="EnsemblBacteria" id="AYE34227">
        <property type="protein sequence ID" value="AYE34227"/>
        <property type="gene ID" value="CP523_07040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59632">
        <property type="protein sequence ID" value="QAS59632"/>
        <property type="gene ID" value="EI377_01785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="304" mass="33754" checksum="133CCF91B5E976D9" modified="2018-12-05" version="1">MKVLEVNNLRKKLGKREIIKGVTFSVEEGEIFGFLGPNGAGKTTTIRMLVGLIKPDSGVISICGHDIQKESIKALEQVGAVVENPELYKYLSGRENLMQIARIRKVSVEEVNDTIKLVGLENRIDDKVKRYSLGMKQRLGLAASLLSSPKLLILDEPTNGLDPSGIIDFREIVKQAARKRGMAVFVSSHILAEVQNLCDRVAFINDGVIKAVEDIHDNTMATEKDIICLVSSSDKATLIKEIKSQTFVQNVREIEKGLEIILESNKTPSLVNALVNANLEIEEVFKERKGLEQRYMELVEGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM5</accession>
    <name>A0A386PFM5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10860</name>
        <name evidence="4" type="ORF">EI377_05655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677623.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02506"/>
    <dbReference type="EnsemblBacteria" id="AYE34865">
        <property type="protein sequence ID" value="AYE34865"/>
        <property type="gene ID" value="CP523_10860"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60260">
        <property type="protein sequence ID" value="QAS60260"/>
        <property type="gene ID" value="EI377_05655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10860"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpaA" evidence="2">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="2">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="2">
        <location>
            <begin position="343"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="397" mass="42584" checksum="6A7F2677E70AB46D" modified="2018-12-05" version="1">MKIETNESRKEKNNLDSKKSEVDNLNENATLTNPKEFTITPEQTKPVEITVNDTAITGTVNITVNDQNNKPVVGAQIQVIDSTGNVVQTVTTNSLGEANITNLPYGNYTLKESKVPEGYILASTNPITISIKANNQVLPENIINTVITGSLQVTKTDEEKTKPIQGATFQIRQSSNSSVVSTQTTNASGQFTVLDLPYGSYNLVEMAVPEGYVLNSNPIPFSIKTNNEVVTQDITNKEKTGELIIKKEDATTSELLEGAVFTITNSAGKSFGTVTTGSDGQGNINLLPGDYIATETTPPSGYVSNTTEQNFTIPFNPQAPVMLTFKDTKQLCKVTITKVDASNTSKVLQGATFTIKTQEGVIVQTLTTGLDGTATTSLSAGTYTLEEIEAPVGYVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFM7</accession>
    <name>A0A386PFM7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_09270</name>
        <name evidence="2" type="ORF">EI377_04015</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678311.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000041.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03044"/>
    <dbReference type="EnsemblBacteria" id="AYE34600">
        <property type="protein sequence ID" value="AYE34600"/>
        <property type="gene ID" value="CP523_09270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60000">
        <property type="protein sequence ID" value="QAS60000"/>
        <property type="gene ID" value="EI377_04015"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09270"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="532" mass="59106" checksum="6C582EB1727B56C9" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFS4</accession>
    <name>A0A386PFS4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09560</name>
        <name evidence="10" type="ORF">EI377_04305</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676676.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02618"/>
    <dbReference type="EnsemblBacteria" id="AYE34650">
        <property type="protein sequence ID" value="AYE34650"/>
        <property type="gene ID" value="CP523_09560"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60049">
        <property type="protein sequence ID" value="QAS60049"/>
        <property type="gene ID" value="EI377_04305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="379" mass="41029" checksum="2B417F5B7BDBC8EE" modified="2018-12-05" version="1">MNFQLTREQELVKQMVREFALNEVKPIAAEIDETERFPIENVEKMAKLKMLGIPFAKEYGGAGGDTLSYILAVEELSKVCATTGVIVSAHTSLCASLIEQFGNKDQKEKYLSDLASGKKLGAFGLTEPGAGTDAAGQQTVAVLEGDHYVLNGSKIFITNGGVAETFIVFAMTDKSKGTKGISAFIVEKEFKGFSIGKKEEKLGIRASSTTELVMENCIVPKENLVGQEGKGFGIAMKTLDGGRIGIAAQALGIAEGAFAEAVAYMKERKQFGRPIAAFQGLQWMIAEMDTKIEAARHLVYKAACLKDAKKPYSVDAARAKLYAAEVAMDVTTKAVQIFGGYGYTKEYPVERMMRDAKITEIYEGTSEVQKMVIAGSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFU0</accession>
    <name>A0A386PFU0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tagatose-bisphosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.40</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-tagatose-bisphosphate aldolase class II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tagatose-bisphosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09610</name>
        <name evidence="10" type="ORF">EI377_04385</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.40" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676692.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02628"/>
    <dbReference type="EnsemblBacteria" id="AYE34660">
        <property type="protein sequence ID" value="AYE34660"/>
        <property type="gene ID" value="CP523_09610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60060">
        <property type="protein sequence ID" value="QAS60060"/>
        <property type="gene ID" value="EI377_04385"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09610"/>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009025">
        <property type="term" value="F:tagatose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011288">
        <property type="entry name" value="TagBP_ald_KbaY/GatY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01858">
        <property type="entry name" value="tag_bisphos_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="7">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="7">
        <location>
            <begin position="231"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="285" mass="31276" checksum="5F406B0C27CC78C4" modified="2018-12-05" version="1">MGNILSTREMLKKAQREGYAVPAFNIHNLETLQVVVETAAELKSPVILAGTPSTIVYAGGEYIVAMAETAAKEYNIPIAIHLDHYEEVDAIKHYVDLGFKSTMIDASHESYENNVRIVKAVVEYAHRFDATVEAELGRLGGQEDDLVVDEKDAMYTNPDQAKDFVDKTGIDSLAVAIGTAHGLYKGEAKLDFERLKEIRAVVEVPLVLHGASDVPDELVKKAISLGICKVNVATDLKIPFSDAVKKYFVENPNANDPRKYMTPGKEAMKKIVEHKIMVCGSNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFZ3</accession>
    <name>A0A386PFZ3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06535</name>
        <name evidence="2" type="ORF">EI377_01020</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677461.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02184"/>
    <dbReference type="EnsemblBacteria" id="AYE34154">
        <property type="protein sequence ID" value="AYE34154"/>
        <property type="gene ID" value="CP523_06535"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59522">
        <property type="protein sequence ID" value="QAS59522"/>
        <property type="gene ID" value="EI377_01020"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06535"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017016">
        <property type="entry name" value="UCP033595"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20124">
        <property type="entry name" value="DUF6514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033595">
        <property type="entry name" value="UCP033595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="105" mass="12507" checksum="F9C9F8CF352031C2" modified="2018-12-05" version="1">MNIVNSLFSIRTEDNKEHKYFYRLLRSQFRGCQAFGIEVERQDIKDGQVVNIERDDIRLISNDENKVNLLLNLLYENQVSPVHLVDVLGEYVDEYIYDFDRVLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG40</accession>
    <name>A0A386PG40_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase</fullName>
            <shortName evidence="4">THcHDO hydrolase</shortName>
            <ecNumber evidence="4">3.7.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">iolD</name>
        <name evidence="8" type="ORF">CP523_11690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D-glucuronate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25836"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28446"/>
            <dbReference type="ChEBI" id="CHEBI:58852"/>
            <dbReference type="EC" id="3.7.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="4">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02897"/>
    <dbReference type="EnsemblBacteria" id="AYE35025">
        <property type="protein sequence ID" value="AYE35025"/>
        <property type="gene ID" value="CP523_11690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11690"/>
    <dbReference type="UniPathway" id="UPA00076">
        <property type="reaction ID" value="UER00145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102481">
        <property type="term" value="F:3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01669">
        <property type="entry name" value="IolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023757">
        <property type="entry name" value="THcHDO_hydrolase_firmi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04377">
        <property type="entry name" value="myo_inos_iolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="7">
        <location>
            <begin position="3"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="5">
        <location>
            <begin position="217"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="6">
        <location>
            <begin position="436"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="4">
        <location>
            <begin position="438"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="639" mass="70709" checksum="401764821A61EF82" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG80</accession>
    <name>A0A386PG80_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN</name>
        <name evidence="8" type="synonym">murJ</name>
        <name evidence="10" type="ORF">CP523_05060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
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        <property type="protein sequence ID" value="AYE33888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33888">
        <property type="protein sequence ID" value="AYE33888"/>
        <property type="gene ID" value="CP523_05060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05060"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="407"/>
            <end position="425"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="463"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="519" mass="58029" checksum="C2ED923A88322874" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGA1</accession>
    <name>A0A386PGA1_CLOSE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11970</name>
        <name evidence="2" type="ORF">EI377_06790</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02951"/>
    <dbReference type="EnsemblBacteria" id="AYE35073">
        <property type="protein sequence ID" value="AYE35073"/>
        <property type="gene ID" value="CP523_11970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60466">
        <property type="protein sequence ID" value="QAS60466"/>
        <property type="gene ID" value="EI377_06790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11970"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="178" mass="20423" checksum="AD5250452E560621" modified="2018-12-05" version="1">MGKTIILNLSDVKLNGDILDVGESFGVIYNLSKDVMDEVSVDYIGSETKHLLLGGEYDTCTIFFCLSNIWSNGTRQNLIKEVTKYLRFGGEICIWDINKDVGEVINNKIRALLPSGKFKEFEFKNLNPLSKSNIDDTKAMLEKYYDIEETKEWEDIHFIKGKKNINEFLEVDTQNCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD6</accession>
    <name>A0A386PGD6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase P</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Cation-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_05325</name>
        <name evidence="11" type="ORF">EI377_15890</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02603"/>
    <dbReference type="EnsemblBacteria" id="AYE33938">
        <property type="protein sequence ID" value="AYE33938"/>
        <property type="gene ID" value="CP523_05325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62089">
        <property type="protein sequence ID" value="QAS62089"/>
        <property type="gene ID" value="EI377_15890"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_C" evidence="8">
        <location>
            <begin position="697"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS62089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="890" mass="97110" checksum="13DF4FEC36BDD4F3" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF0</accession>
    <name>A0A386PGF0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676504.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33736">
        <property type="protein sequence ID" value="AYE33736"/>
        <property type="gene ID" value="CP523_04235"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="245" mass="28058" checksum="4CD1A4F651C76E45" modified="2018-12-05" version="1">MNRSLKICKYQLKSSVKSIMIFYAIFLGVLSLIAYLNKFLHTNTNCSVIEFSTIIFIFICALNSFKYEFYFSQGNNISRKSFLKGTVLYGISLSAILAFIDIIINRLFNLVVSCPMGYDSLYGNAVNLSSSNFFIPNNAINYLISTYLFNISSYIFWFMLAFFIGILMFRLNKSKKFLLLGILVAFIIYINVFSDILLSLMLFITNSFGLNTFNPYKGIISFNILSIIIILGQYLLIRKVEANKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGF2</accession>
    <name>A0A386PGF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_06255</name>
        <name evidence="8" type="ORF">EI377_00730</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00021"/>
    <dbReference type="EnsemblBacteria" id="AYE34101">
        <property type="protein sequence ID" value="AYE34101"/>
        <property type="gene ID" value="CP523_06255"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59468">
        <property type="protein sequence ID" value="QAS59468"/>
        <property type="gene ID" value="EI377_00730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06255"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGDG_synth" evidence="6">
        <location>
            <begin position="14"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="5">
        <location>
            <begin position="218"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="361" mass="41005" checksum="372A2337D3B198F1" modified="2018-12-05" version="1">MNILILTGKFGMGHNSVAKAIAEEFEDIDKNNKVVIVDLLEYLFPIAHHFLYKGFEMMINKCHGIYNMIYRFSEQVEVDVTPLGNKIHEDVNNLILENKPNFIICTLPLCAKIISEYKEKTSSSIPLITCITDISTHKEWQSSYVDNYFVPTSDIKEHLLRNGINKSNIFVTGIPVRRDFKNIGDKLVINNNKKVLIMGGGLGLLPDIDRFIGKLSSISNVEITIITGKNKKAFKYLKENFRSINVVGYTEKVNEYMKEADLIITKAGGITLFEAIHSQTPLFVINPFLEQEKKNAAFIEEKEIGKIAWGNSEDYLRELENLLTTEETLNKMSINISKAKKEIIEVDTSIIVKELYKGVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGG1</accession>
    <name>A0A386PGG1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Cytidine deaminase</fullName>
            <ecNumber evidence="6 9">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_12340</name>
        <name evidence="12" type="ORF">EI377_07230</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675365.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02044"/>
    <dbReference type="EnsemblBacteria" id="AYE35143">
        <property type="protein sequence ID" value="AYE35143"/>
        <property type="gene ID" value="CP523_12340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60548">
        <property type="protein sequence ID" value="QAS60548"/>
        <property type="gene ID" value="EI377_07230"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12340"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="140" mass="15504" checksum="7FB37CBDFC4C03BA" modified="2018-12-05" version="1">MIDRKLLIEKAFEAQKFCYTPYSNFHVGAALLCANGEIYQGCNIENAAYTPTNCAERTAFFKAISEGQNEFTAIAIVGNKAGIKQGEGDFCAPCAVCRQVMAEFCDLKNFKIIIAKSTEEYLEHTLEELLPLAFTGKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGI4</accession>
    <name>A0A386PGI4_CLOSE</name>
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        <submittedName>
            <fullName evidence="3">VanZ family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">CP523_12550</name>
        <name evidence="4" type="ORF">EI377_07440</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675272.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35185">
        <property type="protein sequence ID" value="AYE35185"/>
        <property type="gene ID" value="CP523_12550"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60588">
        <property type="protein sequence ID" value="QAS60588"/>
        <property type="gene ID" value="EI377_07440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12550"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF04892">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="51"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="19921" checksum="A27D29E9901CB9E6" modified="2018-12-05" version="1">MLMNYLDISIFYSMIPLALVIFFIYFGIKFFIKRKVEMKPLKMMCEFAWILIVLFILVTTGFLEGNFSLTSIATGNVNYSFTIFEEGISKDIALNLILFILFGFFLTAIFKKIREKISYGFLIGLAVSIIIEFIKVVTNGLIQLDNILINTLGAYTGYLICIYILEFKNKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGK5</accession>
    <name>A0A386PGK5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1836 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06570</name>
        <name evidence="2" type="ORF">EI377_01060</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677471.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02191"/>
    <dbReference type="EnsemblBacteria" id="AYE34161">
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        <property type="gene ID" value="CP523_06570"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59529">
        <property type="protein sequence ID" value="QAS59529"/>
        <property type="gene ID" value="EI377_01060"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06570"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF1836"/>
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    <dbReference type="PANTHER" id="PTHR40056">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="196" mass="22823" checksum="38E7EEB403AD61C6" modified="2018-12-05" version="1">MVKKIDTSYITDMAEEMSTNNMVSYDDLPKYDLFLSQVIDFLNDKFTEDKYTNNIVQNYIKSEVITKPEDGKKRGYTKIHLVQLVLLSYMRPVLTTEEIKKVFSLAFNEINDRSDDIISWERAYKIFAETQSESFKEFLATSAIDEEKLNEIISELDLNEKDENSIRTFVIVMSLIAQASAIKKLVQKIVNEYHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGL5</accession>
    <name>A0A386PGL5_CLOSE</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07970</name>
        <name evidence="2" type="ORF">EI377_02730</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS59770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675913.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00709"/>
    <dbReference type="EnsemblBacteria" id="AYE34364">
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    </dbReference>
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        <property type="protein sequence ID" value="QAS59770"/>
        <property type="gene ID" value="EI377_02730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07970"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:phosphatase activity"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IIB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="30134" checksum="86A27CC727C90266" modified="2018-12-05" version="1">MKYLACDLDGTLVHENIIKIEDVEAILKLKQKGYKFIISTGRSLNGIDQVFDKYPNVKYDYIVACNGCLILDGDRNIIYDNHITNDVAENVFKDFIDDENICIHFESDGKNYLVDPINTDDIEDLLNYFQGIINREDLFKEKRDYLLISLFARNRDINTADEAKEKLLSKFENELEAYRNQYFIDIVPKGCSKGSGILKVLQLDGGNIEKLYTIGDSYNDISMFKITENSFTFNNSEDGVKEQANNYVDSVSECIEEIIRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGM6</accession>
    <name>A0A386PGM6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ORF">CP523_09155</name>
        <name evidence="10" type="ORF">EI377_03900</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678404.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00269"/>
    <dbReference type="EnsemblBacteria" id="AYE34577">
        <property type="protein sequence ID" value="AYE34577"/>
        <property type="gene ID" value="CP523_09155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59977">
        <property type="protein sequence ID" value="QAS59977"/>
        <property type="gene ID" value="EI377_03900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="130" mass="14540" checksum="D396CB48F9C576E9" modified="2018-12-05" version="1">MAKVQYMGTGRRKKSVARVRLVPGNGNVVVNNREIESYFGLETLRMIVNQPLVLTGTKDKFDVLVNVHGGGFTGQAGAIRHGITRALIKSDEALKSELKKAGFVTRDPRMKERKKYGLKKARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGT4</accession>
    <name>A0A386PGT4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06240</name>
        <name evidence="3" type="ORF">EI377_00715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34098">
        <property type="protein sequence ID" value="AYE34098"/>
        <property type="gene ID" value="CP523_06240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59465">
        <property type="protein sequence ID" value="QAS59465"/>
        <property type="gene ID" value="EI377_00715"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="118" mass="13576" checksum="456A4A275F2789D5" modified="2018-12-05" version="1">MLNLINRRKTPNKIRGFNSKNKDIRGLIVVVSLVIILNFCINLAYLIAKANHECNHDRCDICLQIKHIVKAMDQTKNPIDIVSPIMFLCLLILFLCNLKVKQIIIQPTLVSLKVRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV6</accession>
    <name>A0A386PGV6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">fliP</name>
        <name evidence="14" type="ORF">CP523_02545</name>
        <name evidence="15" type="ORF">EI377_13080</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673932.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00458"/>
    <dbReference type="EnsemblBacteria" id="AYE33419">
        <property type="protein sequence ID" value="AYE33419"/>
        <property type="gene ID" value="CP523_02545"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61593">
        <property type="protein sequence ID" value="QAS61593"/>
        <property type="gene ID" value="EI377_13080"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02545"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788370" description="Flagellar biosynthetic protein FliP" evidence="13">
        <location>
            <begin position="28"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AYE33419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QAS61593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="258" mass="29053" checksum="4B90455D7379DF1C" modified="2018-12-05" version="1">MKNRKKYFFIIFLAIGFMLLHTRSVSAEPNPIQVPNVNISVGGENGTPQDYVDNIKLLITLTILTLLPSIIIMMTSFTRIIVVFSFLKSALGAQQSIPNQVLVGLALFLTIFIMSPVYGEINDKALKPYMANEITQEKAIEIGTKPLREFMYKQTRQKDLELFIETAKINKDEVTKDNVPIQVIIPAFAISELKTAFQIGFLLFMPFLIIDMVVASVLMSMGMFMLPPVMVSLPFKLLLFVMVDGWYLLVKSLVLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGV7</accession>
    <name>A0A386PGV7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ORF">CP523_09495</name>
        <name evidence="11" type="ORF">EI377_04240</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34637">
        <property type="protein sequence ID" value="AYE34637"/>
        <property type="gene ID" value="CP523_09495"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60036">
        <property type="protein sequence ID" value="QAS60036"/>
        <property type="gene ID" value="EI377_04240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09495"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="100"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="160" mass="17304" checksum="AF57E35EE71FB604" modified="2018-12-05" version="1">MRIGLGYDVHRLVAERKLILGGVDIPYKKGLLGHSDADVLVHAIMDSLLGASALGDIGKHFPDTDPKYKGISSISLLEEVGKLLVKNGYSINNIDSTIIAQKPKMAPHIQTMRENIANALKINLDQINVKATTEEGLGFTGKEEGISSQSICLLSKINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGX9</accession>
    <name>A0A386PGX9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_08435</name>
        <name evidence="3" type="ORF">EI377_03180</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674807.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34454">
        <property type="protein sequence ID" value="AYE34454"/>
        <property type="gene ID" value="CP523_08435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59857">
        <property type="protein sequence ID" value="QAS59857"/>
        <property type="gene ID" value="EI377_03180"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08435"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="289" mass="33953" checksum="E47F5ECA6F0BD51C" modified="2018-12-05" version="1">MRNKNNRDKIIELVKLNLDICNISKKIILSILIFSVVIYIITNRLAEVSYSYNLDLNIWDGIFRTTTYSSLILGFYFPYIIILTTFFNTKSDYIKFIMLRTKEKRIWIVSKILTNIVFSFLFTISFFIIVFSINFLMFKFENKWSEIILNKNSIKLAGLLYPNFFVYSFKPLEGFLISFLQIFISSSIVLNLRDLLINYIKSKNVSYSIMSMYLIMNIIIESYGLNEGIFKINEYIGLGTISIIFKHKFKNYNGFTTSLSTSIIISLILLFVILFLNLFFSRKALMEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGY0</accession>
    <name>A0A386PGY0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_04990</name>
        <name evidence="4" type="ORF">EI377_15490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01679"/>
    <dbReference type="EnsemblBacteria" id="AYE33876">
        <property type="protein sequence ID" value="AYE33876"/>
        <property type="gene ID" value="CP523_04990"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62018">
        <property type="protein sequence ID" value="QAS62018"/>
        <property type="gene ID" value="EI377_15490"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04990"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002105">
        <property type="entry name" value="Dockerin_1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00404">
        <property type="entry name" value="Dockerin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033362951" description="TGc domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="169"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS62018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="490" mass="55302" checksum="4F92370634E45B2B" modified="2018-12-05" version="1">MIKIKNLCKLLMTTLILNLFTFSIATSAETLEVHTESVVFDDYKEISEPITAPTLYASVDGKVLIKEAIYKDLLALKPQIDLSAFTDYMGTDKNLAMNLFFDVLAEHPDIFYADNSIRCSYSTSPRDGKLRQYTLMVNYNYDNATIGKMKNELNEKVNYVMNNLIDDSYSEVKKQFIIHDYITQNCTYDSENYNKNTVPAISHTAYGALVNQVAVCDGYSKAMKLLLNKCGIECGVIISNQMAHAWNYVKIGGKYYQMDVTWDDPVPESNKLNYSYFNLSNAEMAKSHQWDQSKYPVGTSTDFDFLRKANSYNTTRVNDRIFYVDNKKLYSSNLTGGDNKTVKSDFSGSNLVGLDDNNSIYYASYVWLYPAPQPTYSVSKLSLADNSIEKVADFKGNISSLYIKDNNLNIKYSDNNVDKTKTIAIAKEEPTVKKDPKDVNGDGVVDILDLSLISTLYNKSSSDSNFNKSFDLNSDNFIDVLDMVPVSKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH88</accession>
    <name>A0A386PH88_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrD</name>
        <name evidence="11" type="ORF">CP523_13960</name>
        <name evidence="12" type="ORF">EI377_08850</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678817.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00159"/>
    <dbReference type="EnsemblBacteria" id="AYE35443">
        <property type="protein sequence ID" value="AYE35443"/>
        <property type="gene ID" value="CP523_13960"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60830">
        <property type="protein sequence ID" value="QAS60830"/>
        <property type="gene ID" value="EI377_08850"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13960"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="299" mass="31845" checksum="FCF74571E629F612" modified="2018-12-05" version="1">MLKVNINGIDFKNPVIAASGTFGFGGEYNNFYNVGILGGISSKGLTLNPKEGNEGIRVYETPSGMMNSVGLQNPGIDRFIKEELPMMKRLGTNIIANVGGGCMEDYEEAICKLRGQDIDMIELNISCPNVKSGGMAFGIKSDVAFDVVSKIKKIADKPIMVKLSPNAENIVDMAVKCQEAGADSISLINTLKGLAINPYKREPIFNNIYAGVSGPAVKPIALRMVHEVAKAVEIPVIGLGGISSGIDAIEFIMAGASAIQIGTVNFINPMAGKEIIEEIENFCISQGIKDINEIVGCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHE7</accession>
    <name>A0A386PHE7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murD</name>
        <name evidence="11" type="ORF">CP523_08680</name>
        <name evidence="12" type="ORF">EI377_03430</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674924.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01677"/>
    <dbReference type="EnsemblBacteria" id="AYE34491">
        <property type="protein sequence ID" value="AYE34491"/>
        <property type="gene ID" value="CP523_08680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59893">
        <property type="protein sequence ID" value="QAS59893"/>
        <property type="gene ID" value="EI377_03430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08680"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="122"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="124"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="459" mass="51555" checksum="F1F846EC182038B6" modified="2018-12-05" version="1">MKRDFKEFKEFIKGKNVAVVGIGVSNIPLINFLFKLGSTVTAFDKKSEAELGDIVNEFKEKGIKLELGERYLDNLTGFDVVFKTPSMRIDCNALVKIKNEGAYITSEMEEFVRYCKGKVYGVTGSDGKTTTTTIVSKLLEAEGYKTWVGGNIGTPLFSQIEEIKEDHMVVLELSSFQLMTMNSPIDVAIATNLAPNHLDMHKNMNEYIDAKKNIFLYQNKDNVLVVNRENEITYNFEKEAKGEVREFSSKREIKNGAYYKDGRLYLEGKEVCKKDDIVIKGMHNVENYLASFIATKDDVSIETMKKVAETFAGVEHRCELVRELNGVKYYNDSIASSPTRTLAGLFAFEKKVILIAGGYDKHIPFEPLAVKGYPYIKELILLGATKEMIKDAFDKVIMEKGITIPIKVVASLNDAVIEAKKIAKEGDIVTLSPACASFDMFPNFAVRGNKFKEIVKNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ4</accession>
    <name>A0A386PHJ4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS sugar transporter subunit IIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_13020</name>
        <name evidence="11" type="ORF">EI377_07895</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677820.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35270">
        <property type="protein sequence ID" value="AYE35270"/>
        <property type="gene ID" value="CP523_13020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60665">
        <property type="protein sequence ID" value="QAS60665"/>
        <property type="gene ID" value="EI377_07895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="14"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="351" mass="36751" checksum="08EBA3E2943F9EE7" modified="2018-12-05" version="1">MGETKVKPKEFLNKILNGLSIGIVIALIPNALLGELLKVVIPHFPQAKIIFDITILIMRMLPMVIGICIAMQFKCNIVQVVSIGIAALIGSGVVNITDKGIFTLIGTGDVINVAITAAIAVIIVLIIGERLKAYTVLLVPSIVAIIAGGIGIITLPYVKEITLLAGNIINKFTNFQPVVMGMLISVCFAILVVSPLSTVAVATAIGLSGIGSGAANLGVVSAAFGLAICGWKVNSFGTAIAHILGSPKMQMANFIKKPIIMLPILCSSSILGALSGIFGIQGTAMSAGFGISGLIGPINAINLMTDGCTLKNLLLVAIIFVVLPIVFGITFNYIFENIVKLVHKDDYKLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ7</accession>
    <name>A0A386PHJ7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05950</name>
        <name evidence="3" type="ORF">EI377_00430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01892"/>
    <dbReference type="EnsemblBacteria" id="AYE34042">
        <property type="protein sequence ID" value="AYE34042"/>
        <property type="gene ID" value="CP523_05950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59414">
        <property type="protein sequence ID" value="QAS59414"/>
        <property type="gene ID" value="EI377_00430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="413" mass="45598" checksum="E442EB54A4B602F5" modified="2018-12-05" version="1">MYDLIVVGGGPAGLAAAYEAYNEGIRNILIIERDNELGGILNQCIHNGFGLHTFKEELTGPEYAQRFIDMLKDTEVKVMLNTMVLDIDKDKNVHAINPEEGYVVLNSKAIILSMGCRERTRGAINIPGDRPAGVFTAGAAQRYINMEGYMPGKKVLILGSGDIGLIMARRMTLEGAKVEGVVELMPYSNGLNRNIVQCLQDYDIPLYLSHTVIDIVGKERLEKVVISEVDEKRKPIKGTEKEFDVDTLLLSVGLIPENELSSKAGIEKDMRTNGLIVSESMETSVDGIFACGNVVHVHDLVDFVTQESKHAGKSAAKYIKDKLKKGESIRIINGQNVNYTVPQKVTVDAIDGNMTVFMRVNNIYHNKVLVVREGEKEIASFKRAHLAPSEMEKIILPKKLLEGVKGDITISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM0</accession>
    <name>A0A386PHM0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">secY</name>
        <name evidence="13" type="ORF">CP523_09075</name>
        <name evidence="14" type="ORF">EI377_03820</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678372.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00254"/>
    <dbReference type="EnsemblBacteria" id="AYE34561">
        <property type="protein sequence ID" value="AYE34561"/>
        <property type="gene ID" value="CP523_09075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59961">
        <property type="protein sequence ID" value="QAS59961"/>
        <property type="gene ID" value="EI377_03820"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS59961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="424" mass="46516" checksum="BF4169FF523E5277" modified="2018-12-05" version="1">MLSTLRNAWKVPELKKKFLWTIFLVAIFRIGIHIPIPGISTSHLKELTGSGTLLGFYDLLSGGALSRFSIFALSVTPYINASIIIQLLTIAIPSLEQLSKEGEEGRKKIQKITRILSIVIGIVLAFGAYQMIASTGATAGITTSEMIVVLVALVTGSTFCMWLGDQITVKGFGNGVSILIFVNIISQLPMTLMSLFTLKDTGKITIVEIALFIVFALALLGATIFFSLAERRVPVQYAGKAVGSKVMRGQSTHIPLSIIGSAVIAIIFAMSVMMFPKTIAMFFQGRDWATWIVSSKYSIFNEKTWMYPVCYSILTIFFTWFYTQITFKPDEMAENLHKSAGFVPGIRPGEATEKYFEKVLTKVSLIGGIFAALLAVLPILISNTSLEGIQFGGTSLLIVVGVALDFSRQLDSQLVMRHYQGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN8</accession>
    <name>A0A386PHN8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TIGR01212 family radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_08145</name>
        <name evidence="9" type="ORF">EI377_02900</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675985.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00743"/>
    <dbReference type="EnsemblBacteria" id="AYE34398">
        <property type="protein sequence ID" value="AYE34398"/>
        <property type="gene ID" value="CP523_08145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59803">
        <property type="protein sequence ID" value="QAS59803"/>
        <property type="gene ID" value="EI377_02900"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="307" mass="35212" checksum="51A4AB6922DA5556" modified="2018-12-05" version="1">MKTWNGKRYHSLNYYLRNKFGEKVYKISLDGGFTCPNRDGRVGRGGCTFCSASGSGDYAGSRALSINKQFEDRKEMMEKKWKDGKYIAYFQAYTNTYAPVDILRKKYEEALKQKGVVALSIATRPDCIDDEIADLLEEISKKTYLWVELGLQTINDNTAKNFNRGYDLKIFDESLKKLKDRNIEVVVHTIFGLPGESKEDMLKTVDYVAHSGVQGIKFHLLHLMEGTKMVEQYKSGELKLMAQEDYIDTICKAVTIIPEEMVVHRLTGDAPRELLIGPMWSLKKWEVLNAIDKALEDNDLWQGKNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHQ4</accession>
    <name>A0A386PHQ4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CP523_06445</name>
        <name evidence="14" type="ORF">EI377_00925</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677427.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02166"/>
    <dbReference type="EnsemblBacteria" id="AYE34136">
        <property type="protein sequence ID" value="AYE34136"/>
        <property type="gene ID" value="CP523_06445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59504">
        <property type="protein sequence ID" value="QAS59504"/>
        <property type="gene ID" value="EI377_00925"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06445"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="325"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS59504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="525" mass="60517" checksum="1B978DA235FBCF45" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHR9</accession>
    <name>A0A386PHR9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="11" type="ORF">CP523_10090</name>
        <name evidence="12" type="ORF">EI377_04890</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676586.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00347"/>
    <dbReference type="EnsemblBacteria" id="AYE34724">
        <property type="protein sequence ID" value="AYE34724"/>
        <property type="gene ID" value="CP523_10090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60125">
        <property type="protein sequence ID" value="QAS60125"/>
        <property type="gene ID" value="EI377_04890"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="90"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="208"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="220"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS60125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="464" mass="52762" checksum="3E5C6A78CAB23622" modified="2018-12-05" version="1">MTKEVYEKKTLAELKEIAKEKGIKNISKLKKIELIESIIENSPKAIEKNGVILQEKITPKQSVTDNKTIDLRENNKEEKKERLQVMINESNTAKGVLEILENNNFGFLRCNNYQTGENDIYVSPSQIRRFNLRTGDEVQGKVREAKEGEKFKALLYVDKVNGENPEKAVGRKSFESLTPIYPEERLHLETINENDLSSRLMDIICPIGKGQRGIIVAPPKAGKTTLLKKVAQNITVNYPEVTLIVLLIDERPEEVTDMKRSINGDVIYSTFDEEPQNHTKVSRMVLERAKRMVEQGKDVVILLDSLTRLSRAYNLTITPTGRTLSGGLDPGALLMPKKFFGAARNIEEGGSLTILATALVDTGSRMDDMIFEEFKGTGNMEVHLDRKLQERRIFPAIDIYKSGTRKEDLILSDEEKEVAYSIRRVMYRDGNIENVTEKLINMLSKTKNNSEFISMFNKSDIERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHU3</accession>
    <name>A0A386PHU3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ORF">CP523_15100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
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    <dbReference type="STRING" id="1504.GCA_900092375_01264"/>
    <dbReference type="EnsemblBacteria" id="AYE35653">
        <property type="protein sequence ID" value="AYE35653"/>
        <property type="gene ID" value="CP523_15100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="566" mass="64779" checksum="A3EEA37D8AB79811" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI00</accession>
    <name>A0A386PI00_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-inhibited division protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01942"/>
    <dbReference type="EnsemblBacteria" id="AYE35713">
        <property type="protein sequence ID" value="AYE35713"/>
        <property type="gene ID" value="CP523_15440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15440"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIDA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="163" mass="18020" checksum="7EDABFEF3FAAFF53" modified="2018-12-05" version="1">MTTYYPLQKLRKIKGLEKAKYVDPYAGSKGNSIRYLSVAPRTNDLKVDGVDNLFCAGEKSGLFVGHTEAICTGSLAGHNAVRLAMGVPLLILPASIAIGDIISYANEKAKTREGRKNRYTFAGAEYFKRMVDEGLYTLDKEEIAARVRKVNLDNVFLQKLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI23</accession>
    <name>A0A386PI23_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1934 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10075</name>
        <name evidence="2" type="ORF">EI377_04875</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676581.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00344"/>
    <dbReference type="EnsemblBacteria" id="AYE34721">
        <property type="protein sequence ID" value="AYE34721"/>
        <property type="gene ID" value="CP523_10075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60122">
        <property type="protein sequence ID" value="QAS60122"/>
        <property type="gene ID" value="EI377_04875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015231">
        <property type="entry name" value="DUF1934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09148">
        <property type="entry name" value="DUF1934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="138" mass="15400" checksum="4BDD39654961BC9F" modified="2018-12-05" version="1">MQKDAIISIKSFTELDKKDIIEVVTPGKFFVEGNMFKAVYEETEISGMAGTTTTLSITDEMFILEREGSTATKMEFKKGDTSISLYNTPYGMMDLQIDTKFLEIDIDENGGDLVAKYSMAISGQEPLMTKIVVNIKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI60</accession>
    <name>A0A386PI60_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_02855</name>
        <name evidence="3" type="ORF">EI377_13380</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677029.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35805">
        <property type="protein sequence ID" value="AYE35805"/>
        <property type="gene ID" value="CP523_02855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62222">
        <property type="protein sequence ID" value="QAS62222"/>
        <property type="gene ID" value="EI377_13380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="188" mass="21286" checksum="6E08AF863E72D5E2" modified="2018-12-05" version="1">MFILAVTAIYDFIFRAGIKFPRIILLVVTIWGAYIVYKKSFLRKSKTSYYMVLIFIFLAMYFGNVWDFYGIPHYDKFLHLGSGAIIAIIGYAFFIALCGQDGLKVINPVTSVVFVIIFSAAAAGIWEIWEFTTDSLFGLTAQNNSLNDTMWDIICGTLVGIITSIPIYMYSKGKNVKFIGNIIKEMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI63</accession>
    <name>A0A386PI63_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11780</name>
        <name evidence="3" type="ORF">EI377_06600</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35037">
        <property type="protein sequence ID" value="AYE35037"/>
        <property type="gene ID" value="CP523_11780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60430">
        <property type="protein sequence ID" value="QAS60430"/>
        <property type="gene ID" value="EI377_06600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11780"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="199" mass="22263" checksum="F696722AC1BCA6C2" modified="2018-12-05" version="1">MSNLFSLLKANFINSIGINKILKEKRVTERYKSIFILVSMVVVAILLVYVGIKYFSLIADVLEASGNIDILLCLVFLASTAFIFFTSIYKAQGVLFSVKGLDMLMSLPITSTTILASKVINLLLLNYLLLIFVLIPPALVYFSRVDLSYLFFIYLFVGLIFMPLTPVIIASIIAFILSYIATKVKFKNLVLNIGTFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI74</accession>
    <name>A0A386PI74_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="5" type="ORF">CP523_07525</name>
        <name evidence="6" type="ORF">EI377_02215</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673811.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01114"/>
    <dbReference type="EnsemblBacteria" id="AYE34302">
        <property type="protein sequence ID" value="AYE34302"/>
        <property type="gene ID" value="CP523_07525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59696">
        <property type="protein sequence ID" value="QAS59696"/>
        <property type="gene ID" value="EI377_02215"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07525"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="162"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS59696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="266" mass="29187" checksum="631D41E0C5A11A6C" modified="2018-12-05" version="1">MNKRIGFIGCGNMGKSMVMGLLKSKSIGNEDILVSTRSNESKEKIEEEIGVKCTLNNVEVAKFSDIIFLAVKPNMYKNVIFEIKDNLKDNAVIITIAAGIELKQVETWFGKDIKIIKTMPNTPALVGEGMSAICPNKLVKEEELNYVCNLYKSFGEYEILAEKDFHGFIALCGSSPAYVFMFIEAMADAAVKLGIPRSKAYKMAAQSVLGSAKMVLETKKHPGELKDMVCSPGGTTIDAVVELENQGFRNSVIKGMEKCAEKSKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIA8</accession>
    <name>A0A386PIA8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CotS family spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10020</name>
        <name evidence="2" type="ORF">EI377_04805</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676655.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00333"/>
    <dbReference type="EnsemblBacteria" id="AYE35855">
        <property type="protein sequence ID" value="AYE35855"/>
        <property type="gene ID" value="CP523_10020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62162">
        <property type="protein sequence ID" value="QAS62162"/>
        <property type="gene ID" value="EI377_04805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10020"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014255">
        <property type="entry name" value="Spore_coat_CotS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02906">
        <property type="entry name" value="spore_CotS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="348" mass="41776" checksum="B3461CA0E532B5F5" modified="2018-12-05" version="1">MNKTRYIDKKILCNYDLSQELFLKLGIDVEDVIPLRKVFILTTSQGKKILKITSSSEKRLEFIDKSLKYISNNYKDVLSYWKNKNGKIYEIWNGDKYVVLDMIEGREATFSNPIEVSICAQAIAKMHKASKGIFNELNTELIQGNMGRYLPEYFNDNLKELEEIKYYTNKFKYKNDFDKLFLENVDYYINYVKRSIELLALSSYKNILEDEDKRVLCHNDLAHHNFIIDGKDVKIIDFDYCNIDTRIVDLVNYTSKVIKNSAYDIEKVRLILESYNKVEKITNDEIKIFYAFMTFPRDFVTIVKDYYYRQKTWDEEVYLNRFKNKLSNEIYRKEFLDNFIEEFKEYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIH9</accession>
    <name>A0A386PIH9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="8">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraY</name>
        <name evidence="9" type="ORF">CP523_14875</name>
        <name evidence="10" type="ORF">EI377_09830</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01308"/>
    <dbReference type="EnsemblBacteria" id="AYE35610">
        <property type="protein sequence ID" value="AYE35610"/>
        <property type="gene ID" value="CP523_14875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60997">
        <property type="protein sequence ID" value="QAS60997"/>
        <property type="gene ID" value="EI377_09830"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14875"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="324" mass="35246" checksum="C8D4E72C8B0E48AE" modified="2018-12-05" version="1">MGDKLIDILTSNLSIALIVGLLISLVLGPITIPILRRLKFGQNIRKEGPQSHLKKAGTPTMGGVIFILSTTITMIIMHFNPTDEAMIALYSFIAFGFIGFLDDMLKIVKKESEGLKAWQKMLLLLIFSSAIAIYGYYNLGTNLKIPFIGTEIPLGILYIPFVIVYYAGATNAVNLTDGLDGLASTVTVLVLTFFTVVAFTMKQESIAIFSIALTGGLLGFLKYNAYPAKVFMGDTGSLAIGGAIATIALVLELPIILFIVGGIYVIETISVILQVGSYKLRGKRLFKMAPIHHHFEQVGWNETKIVTVFAVITVLLCFIGFIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIQ1</accession>
    <name>A0A386PIQ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35710">
        <property type="protein sequence ID" value="AYE35710"/>
        <property type="gene ID" value="CP523_15420"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15420"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="113" mass="13802" checksum="13E151A0974604E7" modified="2018-12-05" version="1">MVHIMKLNEREFENILFNNKILEVRLNDKKRRNIKPGDKIVFHKKNIILETIKVKVIRTYEFRTFNDVYSNFQSKLFGYPEKDKKQMLDLIYSIYTTKEEMYNGVKVIKFYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS1</accession>
    <name>A0A386PIS1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF4080 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_11975</name>
        <name evidence="6" type="ORF">EI377_06795</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673464.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02952"/>
    <dbReference type="EnsemblBacteria" id="AYE35074">
        <property type="protein sequence ID" value="AYE35074"/>
        <property type="gene ID" value="CP523_11975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60467">
        <property type="protein sequence ID" value="QAS60467"/>
        <property type="gene ID" value="EI377_06795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025288">
        <property type="entry name" value="DUF4080"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13311">
        <property type="entry name" value="DUF4080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="169"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="556" mass="66108" checksum="6E1D201BA5F32A4C" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIS6</accession>
    <name>A0A386PIS6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="12" type="ORF">CP523_15575</name>
        <name evidence="13" type="ORF">EI377_10290</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678690.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00167"/>
    <dbReference type="EnsemblBacteria" id="AYE35740">
        <property type="protein sequence ID" value="AYE35740"/>
        <property type="gene ID" value="CP523_15575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61079">
        <property type="protein sequence ID" value="QAS61079"/>
        <property type="gene ID" value="EI377_10290"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15575"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="148"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="316" mass="34702" checksum="D5CB2DEE8345027C" modified="2018-12-05" version="1">MIKEKGNKISIIGAGFVGSTTAYSLMIQGLASDIVIVDINKEKAEAEAMDLSHGAAFVKAVDVKSGTYEDTKDSDIVIITAGIGPKPGETRLDIINKNLNIFKDIIPEVVKYSPNSILLVVSNPVDILTYITYKLSGFPKNRVIGSGTVLDTSRLKYMLSEHFDIDARNVHTYIIGEHGDSEITAWSLTNIAGMDADSYCDTVCSKCDKKFKYEIPNLVKNAAYEIINRKGYTNYAVGLAITRIVEAILRDEDSILTVSSLFEGQYDINDVYLAIPTIIDRNGAKKILEVPLSQDEISKLKESADLLINHLSKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY4</accession>
    <name>A0A386PIY4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Nucleoside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_10825</name>
        <name evidence="4" type="ORF">EI377_05610</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677609.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02499"/>
    <dbReference type="EnsemblBacteria" id="AYE34858">
        <property type="protein sequence ID" value="AYE34858"/>
        <property type="gene ID" value="CP523_10825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60252">
        <property type="protein sequence ID" value="QAS60252"/>
        <property type="gene ID" value="EI377_05610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="2">
        <location>
            <begin position="288"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="551" mass="64100" checksum="7CD425B679C5AB9B" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ00</accession>
    <name>A0A386PJ00_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13805</name>
        <name evidence="2" type="ORF">EI377_08700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677136.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02061"/>
    <dbReference type="EnsemblBacteria" id="AYE35417">
        <property type="protein sequence ID" value="AYE35417"/>
        <property type="gene ID" value="CP523_13805"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60805">
        <property type="protein sequence ID" value="QAS60805"/>
        <property type="gene ID" value="EI377_08700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13805"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="206" mass="23921" checksum="05415E20E3A13FB8" modified="2018-12-05" version="1">MIDINEFDEIIKFKSNKEKISKLKQWSILTESAKDIKKLIYRGTYTDTSIECDVIGYIEKFTNNKCIDIVYDTAIIKIGENILKISPMYLKDMQESDIKINDLQFNYKMLKKYDSTYLECYFNNNSDYNIIAITLDIHLSNSNQTITLNNSKITYKKSVSSTFSTPIPSIENINTITVLQCTIKYKSGNVVCNTIYNSKSKRYTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ26</accession>
    <name>A0A386PJ26_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11075</name>
        <name evidence="2" type="ORF">EI377_05865</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677090.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00925"/>
    <dbReference type="EnsemblBacteria" id="AYE34908">
        <property type="protein sequence ID" value="AYE34908"/>
        <property type="gene ID" value="CP523_11075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60302">
        <property type="protein sequence ID" value="QAS60302"/>
        <property type="gene ID" value="EI377_05865"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="137" mass="15711" checksum="78AA569073BED541" modified="2018-12-05" version="1">MIQIFCASRGSGKTKRLIELANNHVNNCKGDSVYIDDDSRPMRLLKRSIRFVTTKDFEVENCNSLYGLLCGLISQNYDIENIYIDGLSNIVNCTITESTQLFAQLKNLANKFNLNLYINLNCDNKEELPEFIREYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ30</accession>
    <name>A0A386PJ30_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IS6 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_09300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34606">
        <property type="protein sequence ID" value="AYE34606"/>
        <property type="gene ID" value="CP523_09300"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032874">
        <property type="entry name" value="DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003220">
        <property type="entry name" value="InsA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13610">
        <property type="entry name" value="DDE_Tnp_IS240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03811">
        <property type="entry name" value="Zn_Tnp_IS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="155"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="340" mass="38833" checksum="091222A81A303F7D" modified="2018-12-05" version="1">MSKTNIKCPRCNSDKLYKFGMNKQAKQKYQCKQCKRQFVLVDGDGRPKLNNPKCPRCGKGTYLHHAYKHYNRYKCNNKKCNHIIVKHHTTNIDTASSELVSGSLSMKGMRFPLHVILTALTLYFLNNSSTRAISQFLMINAGIKVSHVTIASWTNKFAPFFKQKADKFKASLNLQSDDWHSDETVIFINGERYYLWLAIDSETRFILAFHLTKSRSSDSAYTLVNEAKKFGEPANFITDRLPSYNEAVATLLPNTTHIPVAPMSSDTNNNLIESFNKTFKAWYKSKKGFNSFQKANNLIYLFIFHYNFIRPHGSLNNCTLAEVAGFASDSFAKNSWFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ52</accession>
    <name>A0A386PJ52_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase subunit GlgD</fullName>
            <ecNumber evidence="4">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgD</name>
        <name evidence="3" type="ORF">CP523_06775</name>
        <name evidence="4" type="ORF">EI377_01250</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01460"/>
    <dbReference type="EnsemblBacteria" id="AYE34189">
        <property type="protein sequence ID" value="AYE34189"/>
        <property type="gene ID" value="CP523_06775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59553">
        <property type="protein sequence ID" value="QAS59553"/>
        <property type="gene ID" value="EI377_01250"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="368" mass="42103" checksum="F782CB55B0A4F887" modified="2018-12-05" version="1">MNNCLGIINLDENESRMGELVRYRTLASVPIAARYRVIDFVLSNMANSGIEGIGIFTKNKSRSLINHLTNGRPWDLHRKKDGLRVFNFGEYDPEYDDVHNFVDNIEFIKQSRRDYVLIAPSYMICNIDYSEVIKYHKNSNKDITIVYKKVFDGNEKFIDCDVLNINKDSRVISIGENIGRESNANISMEMYIMKTEVFIDIIYDSIKSGMYRKIKDYISSNLDEIEVGAFEFKGYLACINSLKAYFDTNMDLLTKLVNKELFYENKPIYTKSQDEAPAQYTKRSDVTNSIVANGSYIEGTVKNCIIGRRVHISEGTILENCVIMQNTVIGQNVKMDKVIADKGTLIDENQNIMGTDNHPVTIQKSRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ8</accession>
    <name>A0A386PJJ8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_15190</name>
        <name evidence="12" type="ORF">EI377_10145</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678584.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35667">
        <property type="protein sequence ID" value="AYE35667"/>
        <property type="gene ID" value="CP523_15190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61054">
        <property type="protein sequence ID" value="QAS61054"/>
        <property type="gene ID" value="EI377_10145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15190"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033788343" evidence="9">
        <location>
            <begin position="24"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="59"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="389" mass="43313" checksum="97A45D72FEC625D4" modified="2018-12-05" version="1">MKNMKKILLVLLTISLTSQCLIASPKALVEEEIDIDNEIINLDEEGIYDVDNTKVDTKGPLRVSARNAIAIDAQSKQVLWDQKGYEIVPMASTTKILTSLIAINYGDLDRKVTISKNASSIRGSTVGYKAGEEITMRELLFGLMFRSGNDAAIAIAEDIGGSIEGFANIMNDFARSIGVLNSHFESPHGLDSQKHYSSAYDLAILAAKGMKSEVFREIVGEKTILKDKYDFTRDYQNINKILYRIPGANGVKTGYTGQAGKCLVSSVNHDGRNIIIVVLNCVDRWNQTEKIYNYVISTHTLKSISKKELVENEGFMSLGAIIEDEEFKYGYKENDSLEVEVFKPSIEVKEGDVLGKIILKDNNKERYKTPLKSNTNIGAKEIERVIPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJJ9</accession>
    <name>A0A386PJJ9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isopentenyl-diphosphate delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_07995</name>
        <name evidence="2" type="ORF">EI377_02755</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675922.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00714"/>
    <dbReference type="EnsemblBacteria" id="AYE34369">
        <property type="protein sequence ID" value="AYE34369"/>
        <property type="gene ID" value="CP523_07995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59775">
        <property type="protein sequence ID" value="QAS59775"/>
        <property type="gene ID" value="EI377_02755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="PTHR38149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="566" mass="63884" checksum="BF7565D5189E3E2F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJT0</accession>
    <name>A0A386PJT0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acylneuraminate cytidylyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_10915</name>
        <name evidence="2" type="ORF">EI377_05710</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677644.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02517"/>
    <dbReference type="EnsemblBacteria" id="AYE34876">
        <property type="protein sequence ID" value="AYE34876"/>
        <property type="gene ID" value="CP523_10915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60271">
        <property type="protein sequence ID" value="QAS60271"/>
        <property type="gene ID" value="EI377_05710"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10915"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="243" mass="28271" checksum="C27F20D034CC004A" modified="2018-12-05" version="1">MCKVLCVIQARAGSSRLPKKVLMDLCGKSVLEHVVERLQNSKEIDEIVIATTNEDKDVCIKEAAEKLKIRCFRGDENNVLSRYYLAAKEFKGDIIIRITSDCPLIDPNLVDQVVKAFKSNRYDYVSPRSKDGLIRGLDVEVFSMKALEKAYKECADEMGLEHVTWFMYNNPDKFNLLDYPVPDKFRHPEIRLCVDEIKDYEKILHIYNKFYDGKIIDIERVIEYLLNNPEINNINYDVVQKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJV8</accession>
    <name>A0A386PJV8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ger(X)C family spore germination protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Spore gernimation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11065</name>
        <name evidence="5" type="ORF">EI377_05855</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00927"/>
    <dbReference type="EnsemblBacteria" id="AYE34906">
        <property type="protein sequence ID" value="AYE34906"/>
        <property type="gene ID" value="CP523_11065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60300">
        <property type="protein sequence ID" value="QAS60300"/>
        <property type="gene ID" value="EI377_05855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11065"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038501">
        <property type="entry name" value="Spore_GerAC_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05504">
        <property type="entry name" value="Spore_GerAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02887">
        <property type="entry name" value="spore_ger_x_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0309">Germination</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="372" mass="42620" checksum="197F6453DCAB3BCF" modified="2018-12-05" version="1">MKVKKISKCIIMLLIPLLLGGCFSYQDINKVTFSTSIIFDIDDFGNSVVYLDCIKPYRSTNESSDKGRRIIYKGVGKTSLEALRDINLASSFELNYSQNRAYIFTEKAARNGIRKYLDLINNNQEFQIKPSIFVYFGDIKDLLKVTSSDEEYLGLYLEDLVSKNRKNPRSMQMNINDYLSTSLMANNTNVTGTIEIRDDALDKKIEISGGCVFKDDVLVERIDSKDALSYNLLMDNVRGGTLEMTNPESAKDFITLEILQSKTRSSLKYEGEKLTLIKNIEMKVSLGEIQGKLKVDEELLNYIKSKKQQEIKKYLENIFEKYKSKDLDVFDIERLLEVNYPKEEIKDSMKITNLEVNIDLTIDGTEVVKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJY2</accession>
    <name>A0A386PJY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05525</name>
        <name evidence="2" type="ORF">EI377_00145</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35827">
        <property type="protein sequence ID" value="AYE35827"/>
        <property type="gene ID" value="CP523_05525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62139">
        <property type="protein sequence ID" value="QAS62139"/>
        <property type="gene ID" value="EI377_00145"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="102" mass="12122" checksum="3FC04698ED13C18A" modified="2018-12-05" version="1">MERYPIMQEEYGYDEDELEEYMPNVNNIIDFKNILNPKRIYILNIENEGVAYVGFHFMCLWDEEHDFGVMMHKEKIVKMGGSDSAFLSWIAEEDKSNSELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK28</accession>
    <name>A0A386PK28_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminotransferase-cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14825</name>
        <name evidence="3" type="ORF">EI377_09785</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676102.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01318"/>
    <dbReference type="EnsemblBacteria" id="AYE35601">
        <property type="protein sequence ID" value="AYE35601"/>
        <property type="gene ID" value="CP523_14825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60988">
        <property type="protein sequence ID" value="QAS60988"/>
        <property type="gene ID" value="EI377_09785"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14825"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="24626" checksum="EEF0D1E2A53974B6" modified="2018-12-05" version="1">MLFKEYSINQFIEELSSDDPSPGGGSTAALVSALASSLNSMVYSLTVDKKSFDKLDNDKKEKMLFFQKQAYKFTEISQEFMEKDRQEFVELMAAFKLSKETEEEKITRNKKIKEHTIKAMNIPLNLARESLRFYDNIEFAIKFGNKNLISDAGVAAILLNSAIESAIMNVKINLNSLRNEEFFYVIDKECNEIIKESLNKKVKLTLEVENVIYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK34</accession>
    <name>A0A386PK34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11490</name>
        <name evidence="2" type="ORF">EI377_06305</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34986">
        <property type="protein sequence ID" value="AYE34986"/>
        <property type="gene ID" value="CP523_11490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60379">
        <property type="protein sequence ID" value="QAS60379"/>
        <property type="gene ID" value="EI377_06305"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11490"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="240" mass="26166" checksum="7D20D81A1B9B53D5" modified="2018-12-05" version="1">MNNKNDIRVDGVGKVFGGDYSDIDISGMGTIIDNVKSSSIVVNGIGKSKGDIKTNNFVINGMFDIEGNAEINDLFEINGTFTFKGKVKGGNININGKAIVKEDMNFDNAIVNGVLKVKGICQCEKICVDGKVNIEGLLSGDKIELNIITSNKIREIGGEEVIVRKGINRKIRVLFISKEIIGKLICESIEADKILLEQTKCNIVRGHDITINSGCDIERVEYTGELKINGDSNIKETIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK52</accession>
    <name>A0A386PK52_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_11590</name>
        <name evidence="7" type="ORF">EI377_06405</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35006">
        <property type="protein sequence ID" value="AYE35006"/>
        <property type="gene ID" value="CP523_11590"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60399">
        <property type="protein sequence ID" value="QAS60399"/>
        <property type="gene ID" value="EI377_06405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11590"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="450" mass="49261" checksum="24C7869C4719F3D4" modified="2018-12-05" version="1">MKGSDYLSRILDLGKDNIWKLFLKYSIPSVIGTLIFSIYIVIDGIFVGRAVGSSGLAAINIAMPFFSTALAISLMVSVGGNTITSIELGEGDKEKARQTFSLAFYSLLVVSIMASIITLLFTENIAMFLGAKGDLIKPVGEYLVVLAIFMPIFTCSGYLATGLRTIGKPNYSMMCNIVGSVLNIILDYIMVVKLGMGVFGAALASGIAFTFAFIFGLLGYFNKDSVLKLVKCNIDYKKIFRFFYNGSSEALSEFAFAFSTYLFNIVLMGRLGEMGVSAFSIIQYIASLIVAVYLGISTGISPIISYNYGAKEGNRIREVTKISLLVMSFLGIVCTATLFFAGENLIKLFIDGDAKLIEITVWACKIYSTCFLISGINILSSTYFTALEDARTSIIISLLRGIVFITIGIIVLPIFFDINGIWLTVTFAELLTLLVSYKLMKKSYCSMKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKG1</accession>
    <name>A0A386PKG1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">atpE</name>
        <name evidence="15" type="ORF">CP523_10165</name>
        <name evidence="16" type="ORF">EI377_04980</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676634.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00362"/>
    <dbReference type="EnsemblBacteria" id="AYE34739">
        <property type="protein sequence ID" value="AYE34739"/>
        <property type="gene ID" value="CP523_10165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60141">
        <property type="protein sequence ID" value="QAS60141"/>
        <property type="gene ID" value="EI377_04980"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AYE34739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QAS60141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="77" mass="7526" checksum="25A9FB242BEBB7C6" modified="2018-12-05" version="1">MNEIGMRALGAGIAVLVGLGAGIGIGNATGKAVEGVSRNPETSGKITTALIIGAGFAEATAIYGLLVSILLIFVGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKH7</accession>
    <name>A0A386PKH7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15790</name>
        <name evidence="2" type="ORF">EI377_10495</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS61117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678928.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35781">
        <property type="protein sequence ID" value="AYE35781"/>
        <property type="gene ID" value="CP523_15790"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61117">
        <property type="protein sequence ID" value="QAS61117"/>
        <property type="gene ID" value="EI377_10495"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="121" mass="14452" checksum="FDE7CC1787462A85" modified="2018-12-05" version="1">MKFDKLNLQSPVEFMLEAEESFKKNYSEFRDMMNGRIHEVFKVAIKDEDFLKIAIFNNDYLNISPVDTFLSYYSKKLPKLSEKKLLFVNALFKNLFKFVLKNENEFKEVNYSIINNTKIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKI3</accession>
    <name>A0A386PKI3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YlmC/YmxH family sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01075</name>
        <name evidence="3" type="ORF">EI377_11570</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674650.1">
        <property type="nucleotide sequence ID" value="NZ_CP034358.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02304"/>
    <dbReference type="EnsemblBacteria" id="AYE35791">
        <property type="protein sequence ID" value="AYE35791"/>
        <property type="gene ID" value="CP523_01075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62210">
        <property type="protein sequence ID" value="QAS62210"/>
        <property type="gene ID" value="EI377_11570"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014238">
        <property type="entry name" value="Spore_YlmC/YmxH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40061">
        <property type="entry name" value="PTHR40061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02888">
        <property type="entry name" value="spore_YlmC_YmxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="10515" checksum="FC46083C3B2B0C84" modified="2018-12-05" version="1">MEDDLILHSLNALRSMEVIDIKNGVKLGFVKDVVIDIKESKIVSIILPSMDKNWFSKEDDIEVPWENVKKAGMDVLLIDTTDIIKDNFKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKS2</accession>
    <name>A0A386PKS2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12995</name>
        <name evidence="3" type="ORF">EI377_07870</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677810.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02539"/>
    <dbReference type="EnsemblBacteria" id="AYE35266">
        <property type="protein sequence ID" value="AYE35266"/>
        <property type="gene ID" value="CP523_12995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60661">
        <property type="protein sequence ID" value="QAS60661"/>
        <property type="gene ID" value="EI377_07870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="Alpha_ANH_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="PTHR12196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="218" mass="24893" checksum="4D93F3300EEC2349" modified="2018-12-05" version="1">MKRKFIMSYSCGKDSTLALHRMIKSGNIPLGLLVTVDKKHSRSWFHGVPKKVLKEVSKSLNIPLLLVECEGEEYEYSFEKILKEAKNNLGADSCVFGDIDLEEHRTWCTDRCNKVSMEAIFPLWNEGREKLTYEFIESGYKAVIKNVKLEFLSTYFLGKVLNKDIVNEIKATGADVCGENGEYHTFVYDGPLFNFRIKFNTNGNILNNTHGFLDIGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKU0</accession>
    <name>A0A386PKU0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tyrS</name>
        <name evidence="10" type="ORF">CP523_11080</name>
        <name evidence="11" type="ORF">EI377_05870</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00924"/>
    <dbReference type="EnsemblBacteria" id="AYE34909">
        <property type="protein sequence ID" value="AYE34909"/>
        <property type="gene ID" value="CP523_11080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60303">
        <property type="protein sequence ID" value="QAS60303"/>
        <property type="gene ID" value="EI377_05870"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="406" mass="45592" checksum="49DBB595FFB1F843" modified="2018-12-05" version="1">MASVLDELLERGYIKQFTHEAETRELLEKEKITFYIGFDPTADSLHVGHFIAMMFMAHMQRAGHRPIALLGGGTAMVGDPSGKTDMRKMLTKEEIQHNVDSIKKQMERFIDFSDDKAILVNNADWLLDLNYVDFLREVGVHFSVNRMLSAECFKQRLEKGLSFLEFNYMLMQGYDFYVLNDKYNCKMELGGDDQWSNMIAGVELVRRKSQTQAMAMTCSLLTNSQGQKMGKTVGGALWLDPNKVSSFDFYQYWRNVDDADVEKCLSLLTFVPMDEVKRLSNLEGAAINEAKTVLAYEVTKLVHGEEEATKAKTAAEALFAGGVDMSNVPTVKLSKDTIGKTILDIMAENKIVPSKSEGRRLIQQGGLSLNGVKVTEISRTLKESDLDGGSALIKRGKKNYNKIVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKW6</accession>
    <name>A0A386PKW6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xseB</name>
        <name evidence="5" type="ORF">CP523_15070</name>
        <name evidence="6" type="ORF">EI377_10025</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676015.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01270"/>
    <dbReference type="EnsemblBacteria" id="AYE35648">
        <property type="protein sequence ID" value="AYE35648"/>
        <property type="gene ID" value="CP523_15070"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61035">
        <property type="protein sequence ID" value="QAS61035"/>
        <property type="gene ID" value="EI377_10025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15070"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="73" mass="8478" checksum="7ABD1D2F101F1DC0" modified="2018-12-05" version="1">MAKKETYNEMLEKLQDVLKNLEENELNLEESMKEYEAGVKLINKLYKTLNSLEGKLITIKDNIEVETTIGNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKZ1</accession>
    <name>A0A386PKZ1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_11505</name>
        <name evidence="2" type="ORF">EI377_06320</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673316.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02859"/>
    <dbReference type="EnsemblBacteria" id="AYE34989">
        <property type="protein sequence ID" value="AYE34989"/>
        <property type="gene ID" value="CP523_11505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60382">
        <property type="protein sequence ID" value="QAS60382"/>
        <property type="gene ID" value="EI377_06320"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="88" mass="10085" checksum="CD791C2635707A08" modified="2018-12-05" version="1">MDQEKKKALQPLKTAKGQLEGIIKMIEDDRYCIDVSNQILAAQSLLRKANLMILKNHLNHCVKEACNHNDSDEKIDEINKILEKILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL38</accession>
    <name>A0A386PL38_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_15615</name>
        <name evidence="8" type="ORF">EI377_10330</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678626.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00568"/>
    <dbReference type="EnsemblBacteria" id="AYE35748">
        <property type="protein sequence ID" value="AYE35748"/>
        <property type="gene ID" value="CP523_15615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61085">
        <property type="protein sequence ID" value="QAS61085"/>
        <property type="gene ID" value="EI377_10330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="692" mass="78451" checksum="63E4B7C4276BE2C1" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL39</accession>
    <name>A0A386PL39_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HDIG domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Poly(A) polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14555</name>
        <name evidence="3" type="ORF">EI377_09525</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678676.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00201"/>
    <dbReference type="EnsemblBacteria" id="AYE35552">
        <property type="protein sequence ID" value="AYE35552"/>
        <property type="gene ID" value="CP523_14555"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60938">
        <property type="protein sequence ID" value="QAS60938"/>
        <property type="gene ID" value="EI377_09525"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14555"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="231" mass="27208" checksum="68BA823434370512" modified="2018-12-05" version="1">MNDEEVFKKLDNILKCEEFPSYFINSIRNDKEFKESKFNILNKLEGIEQEKRFHPEGNVWNHTCMVTDKAAEVSNFADDKRSFMWAALLHDVGKVTNTKWIRGRWRSYDHDTAGANIVRDILSLVSSDKRFNLRVETLVKFHMHHIYIDKNLPFGDMKGLIDTNNIKDLMLIFTCDKLGRGNKDTKDRKNIFCELKSILGKIEKEANCQYKDIKEILSYIERKECSLKEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL54</accession>
    <name>A0A386PL54_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AEC family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_15725</name>
        <name evidence="9" type="ORF">EI377_10440</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678900.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00105"/>
    <dbReference type="EnsemblBacteria" id="AYE35768">
        <property type="protein sequence ID" value="AYE35768"/>
        <property type="gene ID" value="CP523_15725"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61106">
        <property type="protein sequence ID" value="QAS61106"/>
        <property type="gene ID" value="EI377_10440"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15725"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="300" mass="33888" checksum="139EBF9C763ED2FD" modified="2018-12-05" version="1">MNLNEVLMKVVSMFLIMSIGVYGGKKKIVTDELQESMTGFIFNITLPFLIITSFSFSYDSSMLSNIVKAFIYSFLSFIILIIVNYICIKPIGENKGMIMKFSNVFSNCGFIGVIAIESIFGAEGMIYASIFNMTFYSLLWIYGRKVYTGNKNESYVNPGTISICLGLLMVIFNIKLPNFIYYSFKVVGDITTPLVLLIIGSIIGEVDYRSVFSDITIYYSVFIKLIIMPGIIFILAKLLNEDSMVISTIILLQAMPTSEFSTIFAKRYKNDYKYSSALMLVSTLLFTLTFPIIVKLVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL62</accession>
    <name>A0A386PL62_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ORF">CP523_15775</name>
        <name evidence="13" type="ORF">EI377_10485</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678925.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000056.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00115"/>
    <dbReference type="EnsemblBacteria" id="AYE35778">
        <property type="protein sequence ID" value="AYE35778"/>
        <property type="gene ID" value="CP523_15775"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61115">
        <property type="protein sequence ID" value="QAS61115"/>
        <property type="gene ID" value="EI377_10485"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15775"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="19"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="363"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE35778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS61115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="554" mass="61824" checksum="7C1B011DFB4713F5" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLK3</accession>
    <name>A0A386PLK3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ImmA/IrrE family metallo-endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_13330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677505.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00762"/>
    <dbReference type="EnsemblBacteria" id="AYE35329">
        <property type="protein sequence ID" value="AYE35329"/>
        <property type="gene ID" value="CP523_13330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="244" mass="28891" checksum="DE99C541E43CAFA9" modified="2018-12-05" version="1">MTEDRKEKIEKVAKSIKKKLREEYKVTDFSDPFKVISLLDNYIIIRFKNDKDIQGFTLKKGDFRCIYINSSDFLGRQNYSCWHEFFHCIDDVNEVTISKKGDNSPGEQEAEYFASCMLLDKEEVDRYIREVWGSEKYLNEEALIKIQYRFNVSFGSLKTRLAEIYKNKKYFSYNINSVKNRKKYEDEVLRLGFDLQLISPTNDFCVPSSFINNLRENIMSNRISLDKGNKIVEFLDENGADIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLW8</accession>
    <name>A0A386PLW8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_05475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35826">
        <property type="protein sequence ID" value="AYE35826"/>
        <property type="gene ID" value="CP523_05475"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05475"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001887">
        <property type="entry name" value="Barnase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00117">
        <property type="entry name" value="BARNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="163" mass="18411" checksum="B93D01A32B813FC6" modified="2018-12-05" version="1">MGYLPEIANKIKNGERFERIVDSIRGAKGGGNPEAHNVVNYMKLKEQYKVTELGNDVVESLRTTGKLPSEYITEQEALNAGWKRGKALNNYAPGKKYGGDIFKNDTKVLPDAQGRVWYEADVGLDYTRGRNNNPGYRILYSNDGLIYGTYDHYESVFKIGTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLY6</accession>
    <name>A0A386PLY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF523 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14645</name>
        <name evidence="2" type="ORF">EI377_09610</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678863.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00145"/>
    <dbReference type="EnsemblBacteria" id="AYE35569">
        <property type="protein sequence ID" value="AYE35569"/>
        <property type="gene ID" value="CP523_14645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60955">
        <property type="protein sequence ID" value="QAS60955"/>
        <property type="gene ID" value="EI377_09610"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS60955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="157" mass="16696" checksum="7A5A9C6DDA5CA2AB" modified="2018-12-05" version="1">MYIISGCLCGVNCKYNGKNNINPQCVKLLEEGKAILVCPEQLGGLTTPRRPAEIKGTANGVFEGVDKLLNDEGVDVTENFKKGALEVLNIAKILNVEGIILKEGSPSCGVNFVYDGSFSGKKINGMGLTTFLLKKNGFKVISEVNLGGEKSGVLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM18</accession>
    <name>A0A386PM18_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_14975</name>
        <name evidence="3" type="ORF">EI377_09930</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676052.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35629">
        <property type="protein sequence ID" value="AYE35629"/>
        <property type="gene ID" value="CP523_14975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61016">
        <property type="protein sequence ID" value="QAS61016"/>
        <property type="gene ID" value="EI377_09930"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14975"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="167" mass="19633" checksum="D302E5A28355D325" modified="2018-12-05" version="1">MKIENFTKAFGWNHKKEKGYTLIEIMVVLFISTLITTMTLKLVISLYDKYKKLENISMKMNFVDDASLTIARLSNEFMIDKIIFNEDINGRNSSIKIIYFQDVNNDKLKKEKIIRLNNKKELILESRNDTGLNFILKNVEEFKVIKKINIFYVLIKHATGDTRIQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PMD3</accession>
    <name>A0A386PMD3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF3793 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DUF3793 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_08160</name>
        <name evidence="2" type="ORF">EI377_02915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01575"/>
    <dbReference type="EnsemblBacteria" id="AYE35849">
        <property type="protein sequence ID" value="AYE35849"/>
        <property type="gene ID" value="CP523_08160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59806">
        <property type="protein sequence ID" value="QAS59806"/>
        <property type="gene ID" value="EI377_02915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024523">
        <property type="entry name" value="DUF3793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12672">
        <property type="entry name" value="DUF3793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="211" mass="25310" checksum="6E327F4E98888AC8" modified="2018-12-05" version="1">MEEKQKQFYNVLNSMPNKEYMELYLLYSLAPVIAGFKPSSTINFKSDYRELYSQWNLYGKEFIEKLGLNYISLRDQENYIVVLIYKKETLKNYLLQDNNIDFLKRLGYDESKELEQWLETLKVRYDRYHCPHEIGLFLGIPIEDVIDFMDCTDKKCLMCGYWKVYNDCYKAKKIFNDYDNSKQYVVNSILEGRSTLSLVNDIQTNFFKFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBF5</accession>
    <name>A0A386PBF5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cas1b</name>
        <name evidence="9" type="synonym">cas1</name>
        <name evidence="10" type="ORF">CP523_01650</name>
        <name evidence="11" type="ORF">EI377_12170</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00881"/>
    <dbReference type="EnsemblBacteria" id="AYE33255">
        <property type="protein sequence ID" value="AYE33255"/>
        <property type="gene ID" value="CP523_01650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61426">
        <property type="protein sequence ID" value="QAS61426"/>
        <property type="gene ID" value="EI377_12170"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01650"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="327" mass="38947" checksum="D3444DF9EC92429C" modified="2018-12-05" version="1">MGKDYYVFSPGRIKRKDNTIYFINTDEEKRGIPIESIERIHFFSEVDLNSKFINYISQYKIILNFYNYYGFYSGSYYPRKKNVSGFLLVEQAVAYKDLESRLFLAKAFIDSAIHHILRNMRRYDKVPNEYFEKIAEEKERMLKANSIPEIMGAEGRIRKIYYESYQYILKNDFGFTNRNRRPPKDPLNALISFGNSVMYTAILGEVYQTQLDPTISYLHEPSTKRFSLILDISEIFKPLIIDTIIFSLINNRRLNNKDFTNEEGVCFLNDEGKKKFLTEFEKKMATSIKHRKLKRSVSYRQLIKLEGYKIIKHLINDEKYKPLKAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBL5</accession>
    <name>A0A386PBL5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M48 family peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00025</name>
        <name evidence="3" type="ORF">EI377_10510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE32947">
        <property type="protein sequence ID" value="AYE32947"/>
        <property type="gene ID" value="CP523_00025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61120">
        <property type="protein sequence ID" value="QAS61120"/>
        <property type="gene ID" value="EI377_10510"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00025"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="234" mass="28693" checksum="A2C8114D4301784E" modified="2018-12-05" version="1">MKFYYRDELIEFVIVYRDRKTLSIQIDMDGKVKVISPKSFHEKYILSIVETKGKWILNKLNLIKSRKNRIPSYKYINGERYLYLGEYYNLVIKKGSFNTEYANILSLGKLLEVKINSIENIRGILEKFYRYESFKIINERVEYYKRYFRIKPKQIKVKEQKRIWASCTFENKLLFNWRLSMMPIDVIDYIIIHEMCHMEYKNHSKEFWNDVYRVMPNYKEKEMWLKENGCIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBM2</accession>
    <name>A0A386PBM2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02080</name>
        <name evidence="2" type="ORF">EI377_12600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33333">
        <property type="protein sequence ID" value="AYE33333"/>
        <property type="gene ID" value="CP523_02080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61503">
        <property type="protein sequence ID" value="QAS61503"/>
        <property type="gene ID" value="EI377_12600"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02080"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="70" mass="8258" checksum="9CBC6D625428BBDF" modified="2018-12-05" version="1">MKIKMICNLTNKEEFINIPIDENRLLSIQGNLMNRNTDGYILGTDVKYYDENNNEINDIFSLNKYLLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBR3</accession>
    <name>A0A386PBR3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RnfABCDGE type electron transport complex subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_01310</name>
        <name evidence="7" type="ORF">EI377_11810</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675562.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00813"/>
    <dbReference type="EnsemblBacteria" id="AYE33190">
        <property type="protein sequence ID" value="AYE33190"/>
        <property type="gene ID" value="CP523_01310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61360">
        <property type="protein sequence ID" value="QAS61360"/>
        <property type="gene ID" value="EI377_11810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="313" mass="34755" checksum="B139F307206C45C9" modified="2018-12-05" version="1">MIRNLFGNVTVFNKLFTLQENNVFNIESAPLVSEEVKDLSEFLISNYKGKNSEVVLVKAFSFQPNINGFEVIVKERKAEIEAGILKIKELTGAKEVKFLVSKADKNLDASLSQLGQVVKVNPLDEFYEDRLVQKALGGGKNALIEDLSKVVYLGQTIKEDNLQLYIPVYGSAVKGNKVISVNEGTSLEVIFNALDGDKAKLRKIVVGGSLNGELKYDLSEKVDINTKSILFLTDKDSPSENSTSCIRCSKCLRACPEGLNPIKLMDLWKRKEKDEFLKFGGEKCIECGMCSYVCPSNLELTQSIKTAKKYIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBZ0</accession>
    <name>A0A386PBZ0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_00620</name>
        <name evidence="2" type="ORF">EI377_11110</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00655"/>
    <dbReference type="EnsemblBacteria" id="AYE33057">
        <property type="protein sequence ID" value="AYE33057"/>
        <property type="gene ID" value="CP523_00620"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61226">
        <property type="protein sequence ID" value="QAS61226"/>
        <property type="gene ID" value="EI377_11110"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00620"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="242" mass="26825" checksum="9B06C48D474FD4B7" modified="2018-12-05" version="1">MNEFFNKTNLETDKNIENEKAEVDKDREKREEIKEFGNANGVTNDESVQILPIIGQIEGHQVLPPQTKTTKYEHIIPQLIAMEQNDKVKGVLIILNTVGGDVEAGLAIAEMINSISKPTVSIVIGGGHSIGVPLATSSSYSFITPSATMIVHPVRMNGFVIGVAQTFHYFQKMQERIDNFILRTSKIDKDELKKMMLKSDELLNDMGTILIGKHAVECGLIDEVGGIKDALDKLKHLIEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PBZ8</accession>
    <name>A0A386PBZ8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_02785</name>
        <name evidence="5" type="ORF">EI377_13310</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676978.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00963"/>
    <dbReference type="EnsemblBacteria" id="AYE33465">
        <property type="protein sequence ID" value="AYE33465"/>
        <property type="gene ID" value="CP523_02785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61636">
        <property type="protein sequence ID" value="QAS61636"/>
        <property type="gene ID" value="EI377_13310"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02785"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS61636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="397" mass="44044" checksum="B487042CC7B4D204" modified="2018-12-05" version="1">MNLSKKAKEINPSITLAITAKAKELKNSGIDVVSFGAGEPDFNTPKNIINAAIKAMEEGKTKYTPTNGILELREAICNKFNIDNNLSYNPSQIVVSTGAKQSLANAFMAILNEGDEVIIPTPYWVSYPELVKMAGGNPVFVENGEEEHYKYTIHSLNKALTTKTKAIVLNSPNNPTGTIYTKDELIKIAEFAKKNNLIIISDEIYEKLIYDNNKHVSIASLSKDAYERTIVINGLSKSYAMTGWRIGYSASSNEIAKLMTAIQSHMTSNINSISQYAAVEALNGSQDDIKDMIVEFEKRRNYMVNRLSKIDGVSIINPSGAFYVMVSIKKCYGKKVNGKIINNSLEFASEILEDEKVAVIPGIAFGLDDYIRLSYATSIEVIEEGLNRIERFIKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCD4</accession>
    <name>A0A386PCD4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="4 7">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pduL</name>
        <name evidence="8" type="ORF">CP523_03595</name>
        <name evidence="9" type="ORF">EI377_14125</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PduL family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="4 7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02226"/>
    <dbReference type="EnsemblBacteria" id="AYE33615">
        <property type="protein sequence ID" value="AYE33615"/>
        <property type="gene ID" value="CP523_03595"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61779">
        <property type="protein sequence ID" value="QAS61779"/>
        <property type="gene ID" value="EI377_14125"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03595"/>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="222" mass="24525" checksum="CB0A2EEFB07033BE" modified="2018-12-05" version="1">MNRNLKCDYKELATKIVSVIRENLEDKVSKREIPVGVSNRHIHLSQEDLEILFGKEYQLSEMKKLKQPGQFAAKETVYIAGPKGCIFNVRVLGPVRKSSQVELSRTDSFALGINNCPIRESGDLKGSGDICVIGPKGSIVLKEKAIIAKRHIHMNSNDAESLNVENGQVVNVITLGDRKTVFGEVVVRVNDSYKLELHLDRDEANAAGLSSDDSVEIVELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCE3</accession>
    <name>A0A386PCE3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03655</name>
        <name evidence="2" type="ORF">EI377_14185</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02214"/>
    <dbReference type="EnsemblBacteria" id="AYE33625">
        <property type="protein sequence ID" value="AYE33625"/>
        <property type="gene ID" value="CP523_03655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61789">
        <property type="protein sequence ID" value="QAS61789"/>
        <property type="gene ID" value="EI377_14185"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03655"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="262" mass="30762" checksum="1CAA60387809B722" modified="2018-12-05" version="1">MNLLTLNCHSWQEDNQLDKIKVLARIIKDNKYDVIALQEVSQIISGELISKLSKENYISILLEALKALGETSYKCIWDFSHIGYDIYEEGLAIITRHKIKEWKSFYVSKDTNIKNYKTRKIIEVKIEVNNKDYKFYSCHLGWWDDLEEPFKDQVDKLIDSLDKKYINIIMGDFNNDALIRNEGYDYLLSKGLFDTYYLAREKGERFTVEGKIDGWEDNKSSKVLDFILVNEKVNVVESKIIFNNKNEVKVSDHYGVQVKIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCE5</accession>
    <name>A0A386PCE5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">QueT transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00220</name>
        <name evidence="3" type="ORF">EI377_10665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677381.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01188"/>
    <dbReference type="EnsemblBacteria" id="AYE32984">
        <property type="protein sequence ID" value="AYE32984"/>
        <property type="gene ID" value="CP523_00220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61148">
        <property type="protein sequence ID" value="QAS61148"/>
        <property type="gene ID" value="EI377_10665"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00220"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="166" mass="18111" checksum="1C293FC800438659" modified="2018-12-05" version="1">MKNTLTKRLVKTAIIAALYAILTIILAPISYGPIQFRLSEVMVLLAFFDPFYIGGLTLGCLLSNILGGYGVMDIVFGTIATFMSVSSISLTAKFLKQNKFSLLIASLWPTLFNGVIIGWMLNFVLGVPIFITMLQVAIGEFVVVTILGVSIAIIIKRKYGNKLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCN2</accession>
    <name>A0A386PCN2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02752"/>
    <dbReference type="EnsemblBacteria" id="AYE33723">
        <property type="protein sequence ID" value="AYE33723"/>
        <property type="gene ID" value="CP523_04160"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04160"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="114" mass="13180" checksum="4B684D525D4230FA" modified="2018-12-05" version="1">MYNVDETIYECPVEALSNILGKKWVAEIIWKIKEQKVRFGELQRALDGCSKKMLTQQLELLINNEIIINNKKITNNIVESTYYLSDSGLKLLPIMAKMINWSNNNLSCEKIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCP6</accession>
    <name>A0A386PCP6_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="9" type="ORF">CP523_00810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674602.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02358"/>
    <dbReference type="EnsemblBacteria" id="AYE33094">
        <property type="protein sequence ID" value="AYE33094"/>
        <property type="gene ID" value="CP523_00810"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00810"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="450" mass="49481" checksum="FBDC441BBABA0984" modified="2018-12-05" version="1">MAFEGLSDKLQEAFKKLRGKGKLTEKDIKEAMREVKLALLEADVNFKVVKKFISTVSEKCVGSDVLESLTPAQQVIKIVNDELTNLMGGSESKINFASVGPTVIMMVGLQGAGKTTMSGKLALQLRKQNKKPLLVACDIYRPAAIKQLEVVGKQIDIPVFQMGDKISPVDIAKAGIAHARENGNNIVIIDTAGRLHIDEELMGELKDVKSEVKPNEILLVVDSMTGQDAVNVAESFNNALDVSGVILTKLDGDTRGGAALSIRHMTEKPIKFIGVGEKMSDFEVFYPDRMASRILGMGDVLSLIEKAQAAFDDKEAQDLGAKMLENDFNYEDYLTAMEQMKKLGSLSKIMEMIPGMPKELKDVDFDAGEKQLAKVKAIIYSMTPKERKNPKLLVGSSSRKKRIAKGSGTSLQEVNKLIKGFDMMRKQMKQMKSLQKKAKKGFLGKLPFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCY2</accession>
    <name>A0A386PCY2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Flavin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01280</name>
        <name evidence="3" type="ORF">EI377_11780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675550.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00807"/>
    <dbReference type="EnsemblBacteria" id="AYE33184">
        <property type="protein sequence ID" value="AYE33184"/>
        <property type="gene ID" value="CP523_01280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61354">
        <property type="protein sequence ID" value="QAS61354"/>
        <property type="gene ID" value="EI377_11780"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="168" mass="19437" checksum="45339CE94EA3004A" modified="2018-12-05" version="1">MKETFTNNLEIAMDWLYKQGGFLTVGNMGNANTMTISWGSIGYMWRKPMFIALVREERYTNEFLKDGDTYTVSIPYGDTLKDALKICGSTSGRNTNKEKRANIKFISGKEINTPVIYGCNKYYECKIILKQPIDLDKLNEKDKEIFYKDGNTKHILYFGEIISEYENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCZ2</accession>
    <name>A0A386PCZ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ORF">CP523_02155</name>
        <name evidence="17" type="ORF">EI377_12675</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674059.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00536"/>
    <dbReference type="EnsemblBacteria" id="AYE33347">
        <property type="protein sequence ID" value="AYE33347"/>
        <property type="gene ID" value="CP523_02155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61517">
        <property type="protein sequence ID" value="QAS61517"/>
        <property type="gene ID" value="EI377_12675"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02155"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE33347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS61517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="593" mass="68459" checksum="63FF51F245C76120" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD18</accession>
    <name>A0A386PD18_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA polymerase factor sigma-54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CP523_03995</name>
        <name evidence="12" type="ORF">EI377_14515</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679259.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000074.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01944"/>
    <dbReference type="EnsemblBacteria" id="AYE33690">
        <property type="protein sequence ID" value="AYE33690"/>
        <property type="gene ID" value="CP523_03995"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61845">
        <property type="protein sequence ID" value="QAS61845"/>
        <property type="gene ID" value="EI377_14515"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03995"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="10">
        <location>
            <begin position="97"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="9">
        <location>
            <begin position="297"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS61845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="458" mass="53269" checksum="6A5881BDD9D5E9E2" modified="2018-12-05" version="1">MKLDFNLNLSQEQKLIMTQQMQLSIKLLQMPAYDLREYIDKEFSENPMLEGNFDMVQEEITCQDKINYKEMIKYLEFDNYGSQNYSDYGDNEVSPFNFISEKHSLKEYLYEQLCELNENELVKNIAKYIIENLDDRGYLTMSLSDMSKEIHIEIEILEQALEIIQEFEPNGIGARDLKECLKIQLINQGLLDEEIKLIIDEYLDLIADNKFTLIAKKLKISPKKAQDYGDIIKSLEPKPSRGFFTGDEVNFIIPDACIRKIDREYFVITNDNILPKLSISNVYKKTLLNGGDKKTEEYIKEKLNSAMFLIKSIEQRRSTLVKVLEAIVRRQREYFDKGEKYLKPMTLKEIADELGIHESTVSRAIKDKYVLTSIGTIKVKNMFKSGITSNKNGEDTTVINIKNQIEILVSNENKKKPLSDQIICDELNKKGLNISRRTVAKYREELGIKSSSKRKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PD34</accession>
    <name>A0A386PD34_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_05095</name>
        <name evidence="11" type="ORF">EI377_15655</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676199.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01809"/>
    <dbReference type="EnsemblBacteria" id="AYE33895">
        <property type="protein sequence ID" value="AYE33895"/>
        <property type="gene ID" value="CP523_05095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62046">
        <property type="protein sequence ID" value="QAS62046"/>
        <property type="gene ID" value="EI377_15655"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05095"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS62046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="216" mass="23891" checksum="4E463A93DEC00AD9" modified="2018-12-05" version="1">MLIVEKQPKSIAAENYRTLRTNIQYSSFDKDFRVIVVTSSEPGEGKSTTSGNLALSLAQGDKKVILIDCDLRKPSIHKKFKISNTVGLSDVLIGKEDIMSITKKRGNNLRILTSGKIPPNPSEMLASKVMGKLLEELKERFDYIILDTPPVQAVTDSQILSTRADGTILVVKAEQTKRDSVSNAINLLKKVNANIIGTVLNGVDNKQNQYYYYGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDB7</accession>
    <name>A0A386PDB7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_02845</name>
        <name evidence="11" type="ORF">EI377_13370</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677000.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00975"/>
    <dbReference type="EnsemblBacteria" id="AYE33477">
        <property type="protein sequence ID" value="AYE33477"/>
        <property type="gene ID" value="CP523_02845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61648">
        <property type="protein sequence ID" value="QAS61648"/>
        <property type="gene ID" value="EI377_13370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02845"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="205"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="448" mass="48936" checksum="AB4F723965E957AD" modified="2018-12-05" version="1">MNGREYVDSVLEQVKKRNSGEVEFLDAVTEVLNSLVPVFDKHQEYIKAGILERIVEPERQIFFRVPWIDDNGNIQVNRGFRVQFNSAIGPYKGGLRFHPSVNQSIVKFLGFEQIFKNSLTGLPIGGGKGGSDFDPKGKSDMEVMRFCQSFMSELYKHIGPNIDVPAGDIGVGGREIGYMYGYYKKLKGANDQGVLTGKGLTYGGSLARTEATGYGLVYFTEEMLKDNGLSFAGKTVVISGSGNVAIYATKKAMELGAKVVALSDSNGYIYDENGINLDVVREIKEIKRGRIKEYIDKVPTAQYFDGFRGIWSIKCDIALPCATQGEIDAESAKILVKNGTIAVSEGANMPTTLEAIEILQNASIMFGPAKAANAGGVACSALEMSQNSIRLSWSFEEVDKKLQNIMTNIYQNSKKASEEYGNPKNILLGANIAGFMKVAEAMMSQGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDC5</accession>
    <name>A0A386PDC5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_00310</name>
        <name evidence="10" type="ORF">EI377_10795</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00572"/>
    <dbReference type="EnsemblBacteria" id="AYE33001">
        <property type="protein sequence ID" value="AYE33001"/>
        <property type="gene ID" value="CP523_00310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61169">
        <property type="protein sequence ID" value="QAS61169"/>
        <property type="gene ID" value="EI377_10795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00310"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE33001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS61169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="401" mass="44395" checksum="8C7F65D8B37796B7" modified="2018-12-05" version="1">MRFTNENKGEVFLKEKYKYIQTLMILVIMILMATTEGFINIFGTTIKGDFALSDTRYSLMFTLGSIAYLIFNYVGGSLCDKLGQKNLFLIGLIGVTLGNLILATALNFNIFTMGFIIMQLFMGMMSIAANTIIPLLWITGQAIIMNLTHFSYGAGLSITQKLAGVFLNKGITWRNIYLIGALISLIVFIVFVFIKLPKSKVSKAEKNISLKEILTKKVSWYFIFAMGFYIMAEQSTGRWLPGFIKISYSNLNESQIASYISLFFVSLTLGRLIGGFIAEKLGEIKTVIIFSISGGILFILGLLLGKNGLYIISLSGFFFSIIFPTLVIIVGNTFKISTAYTTGVIISFAGIVNTSMNLALGFLSDLIGIEKAIFLVPIAILMTFIFVSCINWNLKNIKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDL4</accession>
    <name>A0A386PDL4_CLOSE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_06225</name>
        <name evidence="3" type="ORF">EI377_00700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34095">
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        <property type="gene ID" value="CP523_06225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59462">
        <property type="protein sequence ID" value="QAS59462"/>
        <property type="gene ID" value="EI377_00700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06225"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033363027" evidence="1">
        <location>
            <begin position="22"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="267" mass="31105" checksum="F94E7F283F54CC64" modified="2018-12-05" version="1">MKKLILLIVSALILLVGCSKMTLKDFSNESSSDIKRIRFKDTVEIKDLRKLDGKKIKIIGFMANSSPLDKSMIYLMNLPYHNCVYCVPNTNKLINTMAVYPKQGENIEFTEVPIEVVGTLKFENITDETGYSYEYRLVDSEIKPADIKSMDESVKIYTDLVNKGFVTKINKIISEANSIIYYDKQWGSLADVEPIPEEYIKELENMFEVVDKAKYQDIISVVEKLKKLVKNINDILKSKEYYKMEQLENRDYEIFYKVNDWLMKVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDP0</accession>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">EI377_15740</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01825"/>
    <dbReference type="EnsemblBacteria" id="AYE33910">
        <property type="protein sequence ID" value="AYE33910"/>
        <property type="gene ID" value="CP523_05180"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS62061"/>
        <property type="gene ID" value="EI377_15740"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="69" mass="7971" checksum="D3077B768ACF023A" modified="2018-12-05" version="1">MKEELVLKNRLKETRAERKLSQTQLAEMVGVSRNTISSIETGQFNPTAKLALILCIALDKKFEELFYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PDX2</accession>
    <name>A0A386PDX2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS glucose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_06910</name>
        <name evidence="5" type="ORF">EI377_01395</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673635.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00995"/>
    <dbReference type="EnsemblBacteria" id="AYE34203">
        <property type="protein sequence ID" value="AYE34203"/>
        <property type="gene ID" value="CP523_06910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59568">
        <property type="protein sequence ID" value="QAS59568"/>
        <property type="gene ID" value="EI377_01395"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06910"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="43"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS59568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="174" mass="18279" checksum="976AAB84AE93C138" modified="2018-12-05" version="1">MFDFLKNMFKSNEAPQKEEVNKKSSGLLAPVSGQAIPLSEVPDQVFAEKLAGDGIGIIAEGDTVVAPADGELTLVFKTKHAFAMTLDNGLELLVHIGLETVSLNGEGFEQLVEQGTRVKAGTPIMKIDTNFIASKGLSLATPVLITNVDAAKSITPVATGKVVAGETPVVDFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PE71</accession>
    <name>A0A386PE71_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein insertase YidC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yidC</name>
        <name evidence="8" type="ORF">CP523_07645</name>
        <name evidence="9" type="ORF">EI377_02335</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673856.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01138"/>
    <dbReference type="EnsemblBacteria" id="AYE34325">
        <property type="protein sequence ID" value="AYE34325"/>
        <property type="gene ID" value="CP523_07645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59720">
        <property type="protein sequence ID" value="QAS59720"/>
        <property type="gene ID" value="EI377_02335"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07645"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="254" mass="28798" checksum="362CBC91D9A45BBB" modified="2018-12-05" version="1">MMSFLSPVADFLGKIFNGLHEFILQLFHMQPSGVSYVLAIFIFTLIIRLLILPLNVKSTRSNARLQEIQPELQKLQKKYANDPQKMQLEYSKLMKENKVSMFGGCLPTLLPLPILFALYYVFMAIKPGAGMDTSFLWIPDVFAKDPWFILPVLAFLSTYLPSVLLSKSMPQNPDSPMNMSTMNIMMSGMMAFMAINFSAILVIYWVIGGIIQLGQTYFLNYLPYKKKQAEKANKDAESAVVNAKKATPKTKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEA2</accession>
    <name>A0A386PEA2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 20" type="primary">uvrB</name>
        <name evidence="19" type="ORF">CP523_06465</name>
        <name evidence="20" type="ORF">EI377_00945</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677438.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02170"/>
    <dbReference type="EnsemblBacteria" id="AYE34140">
        <property type="protein sequence ID" value="AYE34140"/>
        <property type="gene ID" value="CP523_06465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59508">
        <property type="protein sequence ID" value="QAS59508"/>
        <property type="gene ID" value="EI377_00945"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="429"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="621"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AYE34140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QAS59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="655" mass="75201" checksum="734FABBDD633C574" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEC5</accession>
    <name>A0A386PEC5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalt-precorrin 5A hydrolase</fullName>
            <ecNumber evidence="4">3.7.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbiG</name>
        <name evidence="3" type="ORF">CP523_01455</name>
        <name evidence="4" type="ORF">EI377_11975</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675618.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00843"/>
    <dbReference type="EnsemblBacteria" id="AYE33218">
        <property type="protein sequence ID" value="AYE33218"/>
        <property type="gene ID" value="CP523_01455"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61390">
        <property type="protein sequence ID" value="QAS61390"/>
        <property type="gene ID" value="EI377_11975"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01455"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043779">
        <property type="term" value="F:cobalt-precorrin-5A acetaldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_N" evidence="2">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="203"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="321" mass="35558" checksum="F4CAE0D5E060873D" modified="2018-12-05" version="1">MIGVISVTEKGDILAEKLRGNLDIEIYKKSEIGDFSLDKITNISFEKYNSIIFISSTGIAVRAIAKYLKGKDKDPAVVVVDVCNEFSISLVSGHLGGANNLARKVSKILNNTLVITTATDNLDLLAPDTIAIDNNLVIKDLKMAKIIASKLVNNEGVYFKDDKKEIACPKGYTEVETLKENTLWITNKYEEHKKVLKLIRKDIVLGIGCRKNTDEKKLYDFVSIVLKENNLSLDSIRYIASIDVKKSEKAILNLGNTLKSEMRFFTKEEIAIVEDHYEGSDFVKGAVGVKSVCEPVVELLKAEIIVSKIKNNGMTLAIGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PED5</accession>
    <name>A0A386PED5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PTS lactose/cellobiose transporter subunit IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_01505</name>
        <name evidence="8" type="ORF">EI377_12025</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per trimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675638.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00853"/>
    <dbReference type="EnsemblBacteria" id="AYE33228">
        <property type="protein sequence ID" value="AYE33228"/>
        <property type="gene ID" value="CP523_01505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61400">
        <property type="protein sequence ID" value="QAS61400"/>
        <property type="gene ID" value="EI377_12025"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01505"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34382">
        <property type="entry name" value="PTHR34382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000699">
        <property type="entry name" value="PTS_IILac_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51095">
        <property type="entry name" value="PTS_EIIA_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>ligand shared between all trimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="6">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000699-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="109" mass="12300" checksum="891868A84C706950" modified="2018-12-05" version="1">MDEKLMEVSFGLIANAGEAKALAFDAISKSKEGNFEEAKTLIEKSKKEMHKAHAFQTELITKEASGENVVVNVLLVHAQDHLMNSMNYQQLAEEFITLYERIDKIEKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEK7</accession>
    <name>A0A386PEK7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsY</name>
        <name evidence="7" type="ORF">CP523_00820</name>
        <name evidence="8" type="ORF">EI377_11315</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674596.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02356"/>
    <dbReference type="EnsemblBacteria" id="AYE33096">
        <property type="protein sequence ID" value="AYE33096"/>
        <property type="gene ID" value="CP523_00820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61266">
        <property type="protein sequence ID" value="QAS61266"/>
        <property type="gene ID" value="EI377_11315"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
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        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <begin position="256"/>
            <end position="259"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="303" mass="33238" checksum="07FE1D8DC864F3B2" modified="2018-12-05" version="1">MFGKIFDNLKTGLTKTRDALTDKINEALKLAITIDDDLYEELEEILVMSDIGMDTTMDIIEALKAKIRKEKINDTKEVYPALKEVIKEMLLDGVESKEEEEEKKVLLVIGVNGVGKTTSIGKLASKNKAEGKRVLLAAADTFRAAAIDQLQVWSERAGVDLVRHQEGSDPAAVVFDAINASKSRNVDILICDTAGRLHNKKNLMDELGKIGRIVEREYSEAKKETLLVLDATTGQNAVIQAKQFMEVCPIDGIILTKLDGTAKGGVVISIKNTLNIPVKYIGVGEGIEDLQEFDAESFAEALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER0</accession>
    <name>A0A386PER0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HD family phosphohydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_02210</name>
        <name evidence="4" type="ORF">EI377_12730</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674037.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00525"/>
    <dbReference type="EnsemblBacteria" id="AYE33358">
        <property type="protein sequence ID" value="AYE33358"/>
        <property type="gene ID" value="CP523_02210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61528">
        <property type="protein sequence ID" value="QAS61528"/>
        <property type="gene ID" value="EI377_12730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02210"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
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        <property type="entry name" value="HD_domain"/>
    </dbReference>
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        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="469"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS61528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="682" mass="76694" checksum="1DC0A58F671A4001" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER3</accession>
    <name>A0A386PER3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2812 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33521">
        <property type="protein sequence ID" value="AYE33521"/>
        <property type="gene ID" value="CP523_03085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021359">
        <property type="entry name" value="DUF2812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11193">
        <property type="entry name" value="DUF2812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="398" mass="46418" checksum="B149A83C55D59637" modified="2018-12-05" version="1">MRGYLLKFKRIEPKKIKYSVDIMDKISFFDGKNSESALEYREYCKAAGWEFVCEREKIQIYCSESDLSNNPIHTDEEEKFNCIFKASLKHVLSSLIMILSVVYIQYITIFRSYNVNFLANDIQIFLLFILSIFIIHGVIGVVNFVIWGVKGKVALKKGDVVSYNCFKAMKVRLVLNNISILLMLSLIIYMGTSGEAYMLKLLVLILLATGLLSIIMNFISRSNCKDKKTLNIIVYVVFTIIIFIGINVLVFSEVFSKINSSDTKIEEENYPIVLNDFNDKSINDEGKHIDEEKGILASTLYYSVKGERIDLSYDLFESDYKWTVEYVVNKKMDWLKKFNIKYIKKETNLPSEIQVYKKEDRNTYLMFSDNKIIEINDWNEILSEDELLNKSYEKVFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PER8</accession>
    <name>A0A386PER8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="9">RNAP subunit beta'</shortName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">rpoC</name>
        <name evidence="12" type="ORF">CP523_08935</name>
        <name evidence="13" type="ORF">EI377_03690</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678842.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01786"/>
    <dbReference type="EnsemblBacteria" id="AYE34533">
        <property type="protein sequence ID" value="AYE34533"/>
        <property type="gene ID" value="CP523_08935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59935">
        <property type="protein sequence ID" value="QAS59935"/>
        <property type="gene ID" value="EI377_03690"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="11">
        <location>
            <begin position="225"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="869"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="876"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS59935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1176" mass="130907" checksum="E8E66AC4474118E4" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEU0</accession>
    <name>A0A386PEU0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YjbQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_03240</name>
        <name evidence="3" type="ORF">EI377_13755</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02135"/>
    <dbReference type="EnsemblBacteria" id="AYE33551">
        <property type="protein sequence ID" value="AYE33551"/>
        <property type="gene ID" value="CP523_03240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61714">
        <property type="protein sequence ID" value="QAS61714"/>
        <property type="gene ID" value="EI377_13755"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03240"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="135" mass="15281" checksum="974762E5D6BA6EBF" modified="2018-12-05" version="1">MANLYKHTISISNTQAMIDITNIIKEDLNKSNVTNGIMVVYCPHTTAGITINENADPDVTRDMIYGFEKVYPTMDSKYRHFEGNSHAHLKSSTVGTSQNLIINNGNLILGTWQDIYFCEFDGPRNRTFYVKIIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEW2</accession>
    <name>A0A386PEW2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1622 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01395</name>
        <name evidence="3" type="ORF">EI377_11910</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675589.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00830"/>
    <dbReference type="EnsemblBacteria" id="AYE33206">
        <property type="protein sequence ID" value="AYE33206"/>
        <property type="gene ID" value="CP523_01395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61378">
        <property type="protein sequence ID" value="QAS61378"/>
        <property type="gene ID" value="EI377_11910"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01395"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012427">
        <property type="entry name" value="DUF1622"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07784">
        <property type="entry name" value="DUF1622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="110" mass="12601" checksum="D81A5B5CF657C7C7" modified="2018-12-05" version="1">MLEELLNKYLPSLINLLEVMGIVIVLIGAITAFYRYIKSILTNKEYPIKYTFANNLAMALEFKLAGEILKTVLIKSIDELWIIAAVSLLRGFLALLIYWEMKNEKSETSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PEY3</accession>
    <name>A0A386PEY3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carbohydrate ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03470</name>
        <name evidence="8" type="ORF">EI377_13995</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02245"/>
    <dbReference type="EnsemblBacteria" id="AYE33591">
        <property type="protein sequence ID" value="AYE33591"/>
        <property type="gene ID" value="CP523_03470"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61755">
        <property type="protein sequence ID" value="QAS61755"/>
        <property type="gene ID" value="EI377_13995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03470"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="290" mass="33137" checksum="5FAEAEE4334BB1A8" modified="2018-12-05" version="1">MFGREKKKKEKEELYDWRNRWTPKYICSLILLCIFMIIFIFPFYWIITGAFKDQASTIVIPPQWIPNNPTFQNWTDLARQPLLKWTFNSFFIAISTTFLVCLTSSLAGYVLAKKRFPGRHIIFWLLIIAMALPKQVIMVPLFNILTKLDWINSYKSLILPAVGWPFGIFLMKQFSETIPTELLEAAKIDGCTELGIFKNIVLPIVKPGVGALAIFTFISSWNDYFMQLILIRSTDMQTLPLGIATMQLEFTTNYGLMMAGAALASIPMIIIFLIFQKSFTQGITIGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF64</accession>
    <name>A0A386PF64_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidinol phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_01930</name>
        <name evidence="3" type="ORF">EI377_12450</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01162"/>
    <dbReference type="EnsemblBacteria" id="AYE33306">
        <property type="protein sequence ID" value="AYE33306"/>
        <property type="gene ID" value="CP523_01930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61476">
        <property type="protein sequence ID" value="QAS61476"/>
        <property type="gene ID" value="EI377_12450"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="344" mass="40160" checksum="84FB7295B4694B82" modified="2018-12-05" version="1">MGKKKRKEIKVFNQNDLKFYYGIPHCHTNFSTGKGNPLEAYEYGRKSGLNFMFITDHNSFLSNKVSIKDEIYTRWQGTHYYASKLKKKYEEFLPLVGFECKTSYYGDLNIINSSTFFTGIVKDIKIILLWMLNNPDAFISINHPHKNIRNLTYNPILNKLITSIEVGNGNPAAKYTRHDRYYFGLLDVGWKLGAINGQDNHKMNFGDSENLTVYIGNELSKEALVDSFRSMRTYSTESRFLKFYFTINDNFMGETIVVSDNKLKFMIFAEDIRYRIKEICIITNKNTLVKSIDEINLNHIKYIYEHKREESESWYVIKVIEENNRIAISSPIFVTSNEDILGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF71</accession>
    <name>A0A386PF71_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase U62</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_09920</name>
        <name evidence="6" type="ORF">EI377_04705</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00313"/>
    <dbReference type="EnsemblBacteria" id="AYE34693">
        <property type="protein sequence ID" value="AYE34693"/>
        <property type="gene ID" value="CP523_09920"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60094">
        <property type="protein sequence ID" value="QAS60094"/>
        <property type="gene ID" value="EI377_04705"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09920"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="113"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="226"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE34693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS60094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="447" mass="49211" checksum="6D1C08D384E3F160" modified="2018-12-05" version="1">MEFNIFIQKLFSEAKKAGFDEYEVYYIDRESLSINIYKEEVEKYSLNNSYGLSFRGKMNGKIGYSYTEILDNEAIDMLVKKAKESALSIENEDVHFIYEGDNEYKDIKTYYEELENLPADKLIELAIEIEREAKKLDSRVNNFSGCGIGYNTSSYGIINSKGLNLKSKGNILTAYVAPIIKEGENMHDGFGYIVANSLEEVNPKKIAKDGVEEALSRIGGKSISSKKYRCIINNEAMVSILSTFASTFSGDAAQKGLSLLKDKEGEVIANDKVNLVDNPHLQNGLASVPFDDEGVATVKTSIIKEGKLITLLHNLKTANKANTKTTANGFKNSYTSPVGVSPTNFYIESGLKSFDELIEEIGEGLLITEFAGLHSGANAVTGDFSLAAKGFYIENSKKTFPVEQITVAGNFFNLLKDIEEIGDDLKFPMSSIGSPSVIIRELAIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PF85</accession>
    <name>A0A386PF85_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription-repair-coupling factor</fullName>
            <shortName evidence="9">TRCF</shortName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">mfd</name>
        <name evidence="12" type="ORF">CP523_08525</name>
        <name evidence="13" type="ORF">EI377_03275</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01646"/>
    <dbReference type="EnsemblBacteria" id="AYE34470">
        <property type="protein sequence ID" value="AYE34470"/>
        <property type="gene ID" value="CP523_08525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62157">
        <property type="protein sequence ID" value="QAS62157"/>
        <property type="gene ID" value="EI377_03275"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="642"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="812"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AYE34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QAS62157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="1170" mass="134744" checksum="AFEE69D9ECBE8B17" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFA8</accession>
    <name>A0A386PFA8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-only hydrogenase system regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_03280</name>
        <name evidence="2" type="ORF">EI377_13795</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677229.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02128"/>
    <dbReference type="EnsemblBacteria" id="AYE33558">
        <property type="protein sequence ID" value="AYE33558"/>
        <property type="gene ID" value="CP523_03280"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61721">
        <property type="protein sequence ID" value="QAS61721"/>
        <property type="gene ID" value="EI377_13795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03280"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023860">
        <property type="entry name" value="FeFe-hyd_TM1266"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03959">
        <property type="entry name" value="hyd_TM1266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="82" mass="8789" checksum="D566671A6094A926" modified="2018-12-05" version="1">MKKIAVISAILENPSKCQQEFNEVVATFRGSIRGRMGIPFEEGVSVISITVVGELNDINSLTGKLGNIQGVTVKTAISKIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB3</accession>
    <name>A0A386PFB3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpC</name>
        <name evidence="10" type="ORF">CP523_10195</name>
        <name evidence="11" type="ORF">EI377_05010</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676647.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00368"/>
    <dbReference type="EnsemblBacteria" id="AYE34745">
        <property type="protein sequence ID" value="AYE34745"/>
        <property type="gene ID" value="CP523_10195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60147">
        <property type="protein sequence ID" value="QAS60147"/>
        <property type="gene ID" value="EI377_05010"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10195"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="8">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE34745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="135" mass="15032" checksum="8721770C6F2837FC" modified="2018-12-05" version="1">MAKTFKVDIITPGNEPIHIEVESLQTGTSNGAVEFRANHTAIILSTIPATTTIIKADGKKEKMFTSSGIIYLKDNNLKFCCDAVEYSQDIDLSRAENAKERAEKRLKENKDIDIERAKMALARANARIQTFSIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFB4</accession>
    <name>A0A386PFB4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04100</name>
        <name evidence="2" type="ORF">EI377_14620</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676892.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02765"/>
    <dbReference type="EnsemblBacteria" id="AYE33711">
        <property type="protein sequence ID" value="AYE33711"/>
        <property type="gene ID" value="CP523_04100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61866">
        <property type="protein sequence ID" value="QAS61866"/>
        <property type="gene ID" value="EI377_14620"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04100"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="114" mass="12990" checksum="16D0D7D90709FA82" modified="2018-12-05" version="1">MAYRELIKDHYDDLNNLNSLLNSMVNSYRLLIAGASELYSISLAKKSDVKDAIDRANKLGDVIDDLLDTVQDCGGSYFKYCTIMSKYVKAQTDKNNVLTEVDYELDFDNSERDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFC8</accession>
    <name>A0A386PFC8_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3784 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_05375</name>
        <name evidence="3" type="ORF">EI377_15940</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677986.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33944">
        <property type="protein sequence ID" value="AYE33944"/>
        <property type="gene ID" value="CP523_05375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62096">
        <property type="protein sequence ID" value="QAS62096"/>
        <property type="gene ID" value="EI377_15940"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05375"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017259">
        <property type="entry name" value="UCP037672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12650">
        <property type="entry name" value="DUF3784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="97" mass="11072" checksum="873AF337762BF3EB" modified="2018-12-05" version="1">MYVFHILVGVFLIYLGYQVKIKKDLNLITNYRKKNIKNEKGYANWIGNSEMIAGVVLIISAIATYFTKEIMIISATDWVLVVGLIVSLLVADKKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFE9</accession>
    <name>A0A386PFE9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_01525</name>
        <name evidence="2" type="ORF">EI377_12045</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675649.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33232">
        <property type="protein sequence ID" value="AYE33232"/>
        <property type="gene ID" value="CP523_01525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61404">
        <property type="protein sequence ID" value="QAS61404"/>
        <property type="gene ID" value="EI377_12045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01525"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="10492" checksum="72B55BA7CCC6FFDE" modified="2018-12-05" version="1">MLTEVLSVYFNDGIFSSRYVSEKLGITEEIAEEYKMQLIRMGYIQKQEECTMESCKSCSCGCSGKKLNGVINWDITEKGYKVINNIKKRGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFK6</accession>
    <name>A0A386PFK6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00085</name>
        <name evidence="3" type="ORF">EI377_10565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678942.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00296"/>
    <dbReference type="EnsemblBacteria" id="AYE32959">
        <property type="protein sequence ID" value="AYE32959"/>
        <property type="gene ID" value="CP523_00085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61131">
        <property type="protein sequence ID" value="QAS61131"/>
        <property type="gene ID" value="EI377_10565"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="185"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="317" mass="38010" checksum="DB85B3D4197D7618" modified="2018-12-05" version="1">MITLEKLTSNTMDIFKKLYDRNFLNENYDKDFFSLYNNQNFVIKFLFRKFLKLIRYNDEVIGYIWYDTPLESTIRIWSLYIENDYMGFIDENTLKAFNTSILSYEAIDNPRNTKILTKLGFKRIRPTILMELNLNKYNRYKDINEIKLKLQLENSYVNKIYNSIFNTNYISSKYNNKKFIIGKDEALRCKIQNNIFSTWNREPLKIEDIYSDISQEYYLKDLSLFGMINDKFVGYGQVIYNRNMYTVVNFGIINEFRGFGIGKLLLHDLIVSSKSKGFNKLYIRVDEDNISAQKLYKWAGFVDKCTISRWDRGYKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV2</accession>
    <name>A0A386PFV2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_05075</name>
        <name evidence="6" type="ORF">EI377_15635</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676193.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01805"/>
    <dbReference type="EnsemblBacteria" id="AYE33891">
        <property type="protein sequence ID" value="AYE33891"/>
        <property type="gene ID" value="CP523_05075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62042">
        <property type="protein sequence ID" value="QAS62042"/>
        <property type="gene ID" value="EI377_15635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05075"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="310"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE33891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS62042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="409" mass="46353" checksum="4ECB0DEEDD63BB64" modified="2018-12-05" version="1">MSVLNIIGLGYIGLPTALMFAANGVEVVGTDLNTKLVDTLNRGELTFEEEGLESVFRKALDNGIKFKNEYEVTNRYIITVPTPYIKQSKKIDATYVIAATKQVMEVCEPGTILVIESTISPGTIDRFVRPIIEEKGFKIGEDIHLVHAPERIIPGKMVFELENNSRTIGADSKKVGEEVKSWYERFCTGEIVVTDIKTAEMSKVVENTFRDINIAFANELAKMCDRENMNVYELIKIANKHPRVNILQPGPGVGGHCISVDPWFLVGDYPDIVNVVLGAREVNDGMPQYVFDKIHEIMKENNIKDYSKVGLYGMTYKENVDDLRESPTLQLLSIFEKYNIDNVKVYDPCVKEKKFKNQVENIDTFLKDIELVVVLVSHDEIKENQKLLTNKIIYDTRNIIQSGNKVYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFV9</accession>
    <name>A0A386PFV9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_03320</name>
        <name evidence="7" type="ORF">EI377_13835</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677218.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02120"/>
    <dbReference type="EnsemblBacteria" id="AYE33566">
        <property type="protein sequence ID" value="AYE33566"/>
        <property type="gene ID" value="CP523_03320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61729">
        <property type="protein sequence ID" value="QAS61729"/>
        <property type="gene ID" value="EI377_13835"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03320"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="357" mass="39866" checksum="A09F218B01ABA7BE" modified="2018-12-05" version="1">MQRSKGVNIKNLTKIYLAHSGNSEFKAVDNISIDIKAGEFVTLLGPSGCGKTTTLRMIAGFEIPTEGEIYLGGDKINILTPDKRDTAMVFQSYALFPHLNIYDNIAYGLKLKKMEKKVLDNKVRNIIDLVGLKGMEARYPNQLSGGQQQRVALARALVMEPGVLLFDEPLSNLDAKLRVYMRTEIRKIQKKVGITAVYVTHDQSEAMSLSDRIIIMNKGIVEQVGTPKEIYHTPATEFVADFIGTANFLPGKIIDAEYESVRIKVQDEVFKVPYKGAKSTGDTCKIVLRPEAIEIGEKGIFKGKIITSTFMGAFQDYSIQVGETIIKCEDFNPQIKKIYEEGQDVMINFSKENVHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFW1</accession>
    <name>A0A386PFW1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Motility protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_02565</name>
        <name evidence="11" type="ORF">EI377_13100</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673927.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00454"/>
    <dbReference type="EnsemblBacteria" id="AYE33422">
        <property type="protein sequence ID" value="AYE33422"/>
        <property type="gene ID" value="CP523_02565"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61596">
        <property type="protein sequence ID" value="QAS61596"/>
        <property type="gene ID" value="EI377_13100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02565"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="104"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS61596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="268" mass="29613" checksum="7857F516689AA2D9" modified="2018-12-05" version="1">MKKSDTLTFFGLLVGGILLVYGMMAGSSLRIFWDFPSVLITVGGSFSAVLITYSLKEVKNLGKLFVEAFKETKVSAQDIILQFTDLSKKARREGLLSLEDDISDLKDDFLKKGLQMVVDGIEPETIKEILELEIDEMENRHMKGSSIYSTWGVYAPAFGMIGTLIGLIQMLQNLTDVSNIASGMGKALITTFYGSILANVFCNPMAANLKSKSEQEAQIRQMMLEGILSIQSGVNPRIVEEKLLTYLKPNERLAYLSNTVENNEGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG09</accession>
    <name>A0A386PG09_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF342 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_02770</name>
        <name evidence="2" type="ORF">EI377_13295</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676973.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00960"/>
    <dbReference type="EnsemblBacteria" id="AYE33462">
        <property type="protein sequence ID" value="AYE33462"/>
        <property type="gene ID" value="CP523_02770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61633">
        <property type="protein sequence ID" value="QAS61633"/>
        <property type="gene ID" value="EI377_13295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_02770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005646">
        <property type="entry name" value="FapA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38032">
        <property type="entry name" value="PTHR38032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03961">
        <property type="entry name" value="FapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="590" mass="65591" checksum="9979789AD4463373" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG10</accession>
    <name>A0A386PG10_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Stp1/IreP family PP2C-type Ser/Thr phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_00935</name>
        <name evidence="3" type="ORF">EI377_11430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674541.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02332"/>
    <dbReference type="EnsemblBacteria" id="AYE33119">
        <property type="protein sequence ID" value="AYE33119"/>
        <property type="gene ID" value="CP523_00935"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61289">
        <property type="protein sequence ID" value="QAS61289"/>
        <property type="gene ID" value="EI377_11430"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_00935"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE33119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS61289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="239" mass="26802" checksum="F3E3D7D112000F47" modified="2018-12-05" version="1">MVGIKSDVGNVRKLNEDYALYKEGDKYKIFVVADGMGGHNAGEVASEMASRKVIEFIESNFNYENRYNILKDAVEYANLKVYEFSHGEAEYRGMGTTLTACLVTKEFIQVANVGDSSCYGIKGEKLKKITRDHSLVQELLDFGSITEEEAEKHPQRNIITRAIGTKEWVEVDIFKINPDEYDLFLLCSDGLSNEVKGNDVLSILSEYSDLNKICDILVDLAKSRGGRDNITVLLFEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG32</accession>
    <name>A0A386PG32_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="8" type="ORF">CP523_01040</name>
        <name evidence="9" type="ORF">EI377_11535</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674490.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02311"/>
    <dbReference type="EnsemblBacteria" id="AYE33139">
        <property type="protein sequence ID" value="AYE33139"/>
        <property type="gene ID" value="CP523_01040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61309">
        <property type="protein sequence ID" value="QAS61309"/>
        <property type="gene ID" value="EI377_11535"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01040"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="60"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="274" mass="29244" checksum="474644727C3F5135" modified="2018-12-05" version="1">MRKFKENLLKILLWISAGITLISLIFILGFIFLKGYKLISINFLTANYSASGNGGILPMIVATLYTVVLSVGIATPIGILSAIYLREYARQGKIVKIIRFSTESLAGIPSIVYGLFGAIFFVVTLELGYSILAGALTVSIIILPVIIRTTEEALKSVPDSYREASLGLGATKFQTLYKVIVPSAMPGILAGVILSIGRVVGESAAILLTAGTVAKMPKGIMSSARTLTVQSYLVTKEAGNIEEAAAVGIVLVIIILLLNTIAKLITKKFNKANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG72</accession>
    <name>A0A386PG72_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_03870</name>
        <name evidence="9" type="ORF">EI377_14405</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675504.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01546"/>
    <dbReference type="EnsemblBacteria" id="AYE33666">
        <property type="protein sequence ID" value="AYE33666"/>
        <property type="gene ID" value="CP523_03870"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61828">
        <property type="protein sequence ID" value="QAS61828"/>
        <property type="gene ID" value="EI377_14405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03870"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="342"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS61828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="437" mass="50597" checksum="C31D58441388368D" modified="2018-12-05" version="1">MKNRFSVIKMKPIELLLISIICSCTVYFIFSTIAQINFKKDILKTYEKNYPLDKGIFTSFSEIADNEKLIIKEDLDFKLERNIYSFFNNQKDIIDKIYFNNLKIYPIDIVNIKKPKIKDLKSNGDVEILKVFSINKDYYIDYIKDYIDGEGFENVDFEKGSINIPVLLGSDFKGIYKIGDIIENEKIKKSFKVKGFIEKDKFIFSMTGKPAYGIEGLNSSIVCAYNQEGLERAIKMNLSMKKDEDISNKDTVLIYDLSKIIPSIILKVRPEQELDQAIDELNKRLLNNGLSVELLSMKSDIDTFLERFNYEISFNTLILFIFGILSVLVVSTIINYTIQKFKYNIGILYSIGATTKDILNIFFRRILQISIIALILGGILYVVIRKSVYLFFVNEIKIEYIVYGSLVYMIIIGISFIVPIVKIKKYRPIDLLKDGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PG79</accession>
    <name>A0A386PG79_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_10465</name>
        <name evidence="8" type="ORF">EI377_05240</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674218.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01407"/>
    <dbReference type="EnsemblBacteria" id="AYE34790">
        <property type="protein sequence ID" value="AYE34790"/>
        <property type="gene ID" value="CP523_10465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60185">
        <property type="protein sequence ID" value="QAS60185"/>
        <property type="gene ID" value="EI377_05240"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10465"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="24819" checksum="2FD0A9AF00E5B350" modified="2018-12-05" version="1">MGKKDKNIIEYNFYTKGEEIANAITHGIGTILSVVGVVFLLILAVKSQNTYKILGTSVYSFCLIILYLDSTLYHSLPGKITKKVFRILDHASIYLLIAGTYTPLLIILLNQDKTSMIILITIWIMAIIGIVFKAIWVGKMELLSTIIYIFMGWAIVFNIKTVLNIVPANILFYVVIGGIAYTLGCIFFGLDKMPYNHAIWHIFVMIGSALHYIAIFLCVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD0</accession>
    <name>A0A386PGD0_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12130</name>
        <name evidence="3" type="ORF">EI377_06960</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35103">
        <property type="protein sequence ID" value="AYE35103"/>
        <property type="gene ID" value="CP523_12130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60496">
        <property type="protein sequence ID" value="QAS60496"/>
        <property type="gene ID" value="EI377_06960"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12130"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038750">
        <property type="entry name" value="YczE/YyaS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40078">
        <property type="entry name" value="PTHR40078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="221" mass="23519" checksum="18FB1BDB33419E3B" modified="2018-12-05" version="1">MGGLKVLKNKILKLIRLLVGFILCASSTVLMLNSNLGLSPWDVFHQGISKLTGMTIGEASIAVGVVCVLLGLALGEKLGVGTILNMIIVGKFIDMIIAMNIIPVASNIFMGVIMMIFGMLVMGLGCYLYIGCALGCGPRDGVMVSLSKKFNKSIKFIRSSIEITVLILGFILGGRVGLGTIITALFLGTSIQIIFRVCSFDVANVRHKSVTESIKSNFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGD3</accession>
    <name>A0A386PGD3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN dependent NADH:quinone oxidoreductase</fullName>
            <ecNumber evidence="6">1.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Azo-dye reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azo compound oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">FMN-dependent NADH-azoreductase</fullName>
            <ecNumber evidence="6">1.7.1.17</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">azoR</name>
        <name evidence="8" type="ORF">CP523_06145</name>
        <name evidence="9" type="ORF">EI377_00625</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 a quinone + H(+) + NADH = 2 a 1,4-benzosemiquinone + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:65952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:134225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>anthranilate + N,N-dimethyl-1,4-phenylenediamine + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 H(+) + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:55872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15783"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:71579"/>
            <dbReference type="EC" id="1.7.1.17"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:55874"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the azoreductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.-" evidence="6"/>
    <dbReference type="EC" id="1.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01930"/>
    <dbReference type="EnsemblBacteria" id="AYE34081">
        <property type="protein sequence ID" value="AYE34081"/>
        <property type="gene ID" value="CP523_06145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59451">
        <property type="protein sequence ID" value="QAS59451"/>
        <property type="gene ID" value="EI377_00625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06145"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01216">
        <property type="entry name" value="Azoreductase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023048">
        <property type="entry name" value="NADH:quinone_OxRdtase_FMN_depd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 6" id="KW-0288">FMN</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="215" mass="25284" checksum="DBAE103511B1B35A" modified="2018-12-05" version="1">MKKLLYITVNSKPEEISVSRTVGREFVNKFLEKYSDFKLEELNLYDCHIPRLEYEYFEKRNCMIKKEDFNKLNKEQQEEVHKIVKLTDQFKEADMYVIAAPMWSLSFPAPLKEYIDCIVMDGKTISIKENKIEGLLNDKPRGMVYIQSSGAHIPWMLRIVMNKGLNYIEDIAKAMGIKRFEELLVDGTGFTEEEKLQAIERAKEKIDGIIDEVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE2</accession>
    <name>A0A386PGE2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA_23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_03580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677739.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02229"/>
    <dbReference type="EnsemblBacteria" id="AYE33612">
        <property type="protein sequence ID" value="AYE33612"/>
        <property type="gene ID" value="CP523_03580"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03580"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="598"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="712"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE33612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1164" mass="135830" checksum="9EA189673DAB4237" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGE9</accession>
    <name>A0A386PGE9_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin reductase</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxB</name>
        <name evidence="7" type="ORF">CP523_08795</name>
        <name evidence="8" type="ORF">EI377_03555</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678087.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000036.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02700"/>
    <dbReference type="EnsemblBacteria" id="AYE34507">
        <property type="protein sequence ID" value="AYE34507"/>
        <property type="gene ID" value="CP523_08795"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59910">
        <property type="protein sequence ID" value="QAS59910"/>
        <property type="gene ID" value="EI377_03555"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08795"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="313" mass="34786" checksum="8420DC8434D01BB4" modified="2018-12-05" version="1">MNKEVKEKELIIIGGGPAGLTSAIYATRAKLDMLLLEDKILGGQVRNSYTIENYPGFRKVSGTELSDLMQQQAEELGAEIDEFDVIENVDFSGKDKIVETGDYIYKAKAIIIATGASPKKLPINNEGKLSGKGIHYCAVCDGAMYEGKVVAVVGGGNAALEEAIFLTKFAEKVIMIRRHDYFNGEKATIEEVKNNPKIEIMFNYDLVEAYGENFLEKAKIKNTKTGEEKEINLDAIFGFIGTEPKTEMFKEYINLTPNGYIITDERMRTNIKGVYAAGDVRDKQFRQITTAVSDGTIAALDSEKYIIERRKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGH9</accession>
    <name>A0A386PGH9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_07740</name>
        <name evidence="3" type="ORF">EI377_02435</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34334">
        <property type="protein sequence ID" value="AYE34334"/>
        <property type="gene ID" value="CP523_07740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59731">
        <property type="protein sequence ID" value="QAS59731"/>
        <property type="gene ID" value="EI377_02435"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07740"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027024">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027386">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="64"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS59731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="319" mass="35695" checksum="6CFF73B364D08A68" modified="2018-12-05" version="1">MRKKFSIVISIFLLIGLISCKASKMDLKKVYIILPDGLPAIATSKFIDDNESKSENKFNIALQKTPDALVAEILKGEAEIAVVPSNLALQAYKKGLDYKVVGTVGWGSMYLISTEEINDVSDLNGKEIYNTGKGLTPDIICREILNSKGIDDKKINYSYVNAASELAPMIINNKAKIAVVPEPALSTILAKKPDTKILLDLNLEWKNLKNVDKGYPQSTILIKESFYKDNKKLCNEILDKIKNSIEWVNSNSNDVSGICEKNSITVNKVTLDKALERGNLKYYSIDESKNEYKIYFESIDKITETQEGKVDYEKIFIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ2</accession>
    <name>A0A386PGJ2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01988"/>
    <dbReference type="EnsemblBacteria" id="AYE35195">
        <property type="protein sequence ID" value="AYE35195"/>
        <property type="gene ID" value="CP523_12615"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12615"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="PTHR13246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="171"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="269" mass="29948" checksum="DF3C661F42BAAA3E" modified="2018-12-05" version="1">MGNGYNFFVDGEKVSVMDWNNRSLADVMPAYRWIIENEGNNKLNLSIDFSTAYYGGNSIKFNGKLEGNKTSTIKLYSAELKLEKGVDFKTSAKSNKEVNLDLVLEFEDGTVETIKADKVIGEDWTTISYNVSKFADKVVRTISYKISSSEDISNLTLNLGNKTIEKAPHDITIDLRDVKTVSEVRIAHAEAGGEGPDMNIKEYIIETSLDGENFEEAVKVTKNVLGNTIHAFKATEARYVRFTAVKPTQGSDSATRIYEIEVRGLDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGK4</accession>
    <name>A0A386PGK4_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRD domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcription antiterminator BglG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_11085</name>
        <name evidence="4" type="ORF">EI377_05875</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677086.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00923"/>
    <dbReference type="EnsemblBacteria" id="AYE34910">
        <property type="protein sequence ID" value="AYE34910"/>
        <property type="gene ID" value="CP523_11085"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60304">
        <property type="protein sequence ID" value="QAS60304"/>
        <property type="gene ID" value="EI377_05875"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11085"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="2">
        <location>
            <begin position="73"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="2">
        <location>
            <begin position="178"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="287" mass="32983" checksum="B63718C20B93D95D" modified="2018-12-05" version="1">MGVVLKNDVIVIKSFNNNVVLVHDDGKEKILFDKGIGFGKKPGQYIAKGSSIQKVFIISQEENKRNFKELINRVEDDFIGVFEEALKEIELDLDEELDEKIHIGLIEHLTFAIKRLKNSQEIQNPFLIEVETLYKKEFELACKLAEKIGKHVNIGIPYGEIGFIALHIHSARNNGKLSNTVKYAFLSNSIVEEVEESLNIEIDRQSLDYARFLTHIRFTIERIMNNKSIQNTLVDVIQKKFEESYKISENVAEIISEELDKPVSEDEIAYLAMHIERFKISIEAKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP1</accession>
    <name>A0A386PGP1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_04625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33806">
        <property type="protein sequence ID" value="AYE33806"/>
        <property type="gene ID" value="CP523_04625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04625"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025935">
        <property type="entry name" value="AbiH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14253">
        <property type="entry name" value="AbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="177" mass="21098" checksum="A1A1A635F4D75A8E" modified="2018-12-05" version="1">MYKISDDKIHYVHGECCGEEDDELIIGHGNNQRINEIKKYIDELEEKYDFTQTMSNSINEYNCLLRYIERLKKDVNKHMDICNTFYKRIGDKLDCINVYGLSLGEVDIPYLKQIRAKWPNSKWRFSYYSLEDENRITNIASKLLNLNEDEYETFHFLNSLSNNIRGEIIKIQNIVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGP7</accession>
    <name>A0A386PGP7_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">CP523_11300</name>
        <name evidence="10" type="ORF">EI377_06120</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673239.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02817"/>
    <dbReference type="EnsemblBacteria" id="AYE34950">
        <property type="protein sequence ID" value="AYE34950"/>
        <property type="gene ID" value="CP523_11300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60345">
        <property type="protein sequence ID" value="QAS60345"/>
        <property type="gene ID" value="EI377_06120"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11300"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="277" mass="31310" checksum="377C2EE872E02222" modified="2018-12-05" version="1">MLNIGCHLSTTKGFKNMGVEALKIGANTFQFFTRNPRGGKAKEIDIKDIEGLLEIIRDNKFSKVLAHAPYTLNACSADERTREFARNTMKDDLIRMEYLPNNLYNFHPGSHVKQGIEIGIKYISDMLNDVLKPEQTTKVLLETMAGKGTEVGRSFEEIAEIISKVELKDHLGVCLDTCHIYDAGYDIVNDLDGVLDEFDKIIGLKRLCAIHLNDSKNPFKSHKDRHEKIGEGFIGIEAISKIINHPKLKNIPFFLETPNELEGYEKEIALLRSKYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGU7</accession>
    <name>A0A386PGU7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TQXA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_11560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673338.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02870"/>
    <dbReference type="EnsemblBacteria" id="AYE35000">
        <property type="protein sequence ID" value="AYE35000"/>
        <property type="gene ID" value="CP523_11560"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11560"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023849">
        <property type="entry name" value="CHP03934_TQXA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03934">
        <property type="entry name" value="TQXA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017352643" evidence="2">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="3">
        <location>
            <begin position="69"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE35000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="212" mass="24095" checksum="84C9D1ACF7E98FBA" modified="2018-12-05" version="1">MKYKKSFKLLLMMFILSTIVCTSVKAYTIYTVDEKVTIETENRNLYKVSYENFYLKAKKIIPNNTAEVGYCIDIEKTYPSGEVFSKIDKIDTRATGVLAAGYPNKTKEELGLDNNDEAYFATQIALWSAIEGYDVYKITGDNPKIITAIRNIYNNGINNIVGKNNYESRVYYVNDNIQKVILLSRKQVIEEPPTSEGNQPPTPEENPPIMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH30</accession>
    <name>A0A386PH30_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13735</name>
        <name evidence="4" type="ORF">EI377_08625</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02075"/>
    <dbReference type="EnsemblBacteria" id="AYE35405">
        <property type="protein sequence ID" value="AYE35405"/>
        <property type="gene ID" value="CP523_13735"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60793">
        <property type="protein sequence ID" value="QAS60793"/>
        <property type="gene ID" value="EI377_08625"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13735"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="50"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="264" mass="30701" checksum="A63693F4D779162B" modified="2018-12-05" version="1">MDKIYTVKEVFKINRYKKKFGIIGIFFIIFTITIFNYIPVYTIHSENQKKVVYLTFDDGPTPNVTKEILNILNRNSIKGSFFIVGSNARENKEILKRLHEDDMCIMPHADLHEYDEIFKSVDDYFKDLNNCQKTISSIIGKENFKFIRIPGGSDNSNGSPEVIQEVKNKIKSENRYYIDWTVDSGDTEEQSVSVNFISSRIREYGGLYPVEVVLMHDIGGKETTIASLQYVIDFYKERGYEFNSLDNIEDSQVEYLKKIKVINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PH42</accession>
    <name>A0A386PH42_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyanophycin synthetase</fullName>
            <ecNumber evidence="7">6.3.2.29</ecNumber>
            <ecNumber evidence="6">6.3.2.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyanophycin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cphA</name>
        <name evidence="13" type="ORF">CP523_10055</name>
        <name evidence="14" type="ORF">EI377_04855</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n) + ATP + L-aspartate = [L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13277"/>
            <dbReference type="Rhea" id="RHEA-COMP:13728"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + ATP + L-arginine = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23888"/>
            <dbReference type="Rhea" id="RHEA-COMP:13732"/>
            <dbReference type="Rhea" id="RHEA-COMP:13733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137986"/>
            <dbReference type="ChEBI" id="CHEBI:137990"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.30"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.29" evidence="7"/>
    <dbReference type="EC" id="6.3.2.30" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676573.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00340"/>
    <dbReference type="EnsemblBacteria" id="AYE34717">
        <property type="protein sequence ID" value="AYE34717"/>
        <property type="gene ID" value="CP523_10055"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60118">
        <property type="protein sequence ID" value="QAS60118"/>
        <property type="gene ID" value="EI377_04855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10055"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071161">
        <property type="term" value="F:cyanophycin synthetase activity (L-arginine-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071160">
        <property type="term" value="F:cyanophycin synthetase activity (L-aspartate-adding)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009059">
        <property type="term" value="P:macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011810">
        <property type="entry name" value="Cya_phycin_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044019">
        <property type="entry name" value="Cyanophycin_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18921">
        <property type="entry name" value="Cyanophycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02068">
        <property type="entry name" value="cya_phycin_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="218"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AYE34717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QAS60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="872" mass="97064" checksum="ADD1DB1E92BC54DA" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHG1</accession>
    <name>A0A386PHG1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4446 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF4446 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07605</name>
        <name evidence="4" type="ORF">EI377_02295</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673840.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01130"/>
    <dbReference type="EnsemblBacteria" id="AYE34318">
        <property type="protein sequence ID" value="AYE34318"/>
        <property type="gene ID" value="CP523_07605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59712">
        <property type="protein sequence ID" value="QAS59712"/>
        <property type="gene ID" value="EI377_02295"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07605"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027981">
        <property type="entry name" value="DUF4446"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14584">
        <property type="entry name" value="DUF4446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="18869" checksum="7E5EB45BD25C1233" modified="2018-12-05" version="1">MQNIINMINDYSSFLIIGLAVIVILLFIVVLVLMRSINKVELKYRKMMRGVNNKNLEALINSKLDEIDKAVEKSEESIKQCEITREEMKDCVNKVAIMRYKAFEDVGSDLSFSVAILDSHNDGVMLTGIYSRQESITYAKPIDKGISRYELSEEELHVLNEAMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHJ1</accession>
    <name>A0A386PHJ1_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">CP523_08925</name>
        <name evidence="8" type="ORF">EI377_03680</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678836.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01784"/>
    <dbReference type="EnsemblBacteria" id="AYE34531">
        <property type="protein sequence ID" value="AYE34531"/>
        <property type="gene ID" value="CP523_08925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59933">
        <property type="protein sequence ID" value="QAS59933"/>
        <property type="gene ID" value="EI377_03680"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08925"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="122" mass="12707" checksum="9CFE8CBBBCB4F188" modified="2018-12-05" version="1">MTREDIIQAIKEMSVLDLNELVKACEEEFGVSAAAPVAVAGGAVAGGAAAEEKTEFDVILANAGGQKIKVIKVVRELTGLGLKEAKEIVDGAPKTLKEAVSKEDAEDMKAKLAEVGAEVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHK2</accession>
    <name>A0A386PHK2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_14730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676140.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01338"/>
    <dbReference type="EnsemblBacteria" id="AYE35585">
        <property type="protein sequence ID" value="AYE35585"/>
        <property type="gene ID" value="CP523_14730"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14730"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="437"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="536" mass="61841" checksum="CECD009E74A88550" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHM7</accession>
    <name>A0A386PHM7_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_08090</name>
        <name evidence="4" type="ORF">EI377_02845</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00732"/>
    <dbReference type="EnsemblBacteria" id="AYE34388">
        <property type="protein sequence ID" value="AYE34388"/>
        <property type="gene ID" value="CP523_08090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59793">
        <property type="protein sequence ID" value="QAS59793"/>
        <property type="gene ID" value="EI377_02845"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="155"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE34388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="630" mass="71637" checksum="A167E45B9F8483C8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHN2</accession>
    <name>A0A386PHN2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ORF">CP523_06155</name>
        <name evidence="12" type="ORF">EI377_00635</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066675149.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01932"/>
    <dbReference type="EnsemblBacteria" id="AYE34082">
        <property type="protein sequence ID" value="AYE34082"/>
        <property type="gene ID" value="CP523_06155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59452">
        <property type="protein sequence ID" value="QAS59452"/>
        <property type="gene ID" value="EI377_00635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06155"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5034628676" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034628677" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="139" mass="15967" checksum="A7492FDAFBD154EF" modified="2018-12-05" version="1">MKIEQLGRHILVEYYNCDKEILKDHAIIEEYMKQAAIEANATIVTSCFHKFNPWGVSGAVIIQESHLTIHTWPEYGYASVDLFTCGDSVNPWFGFRYLEEVLKAERSESTEVARGLVDKVKTFANGAYDHIEIDYKMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHP1</accession>
    <name>A0A386PHP1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_14950</name>
        <name evidence="2" type="ORF">EI377_09905</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01294"/>
    <dbReference type="EnsemblBacteria" id="AYE35625">
        <property type="protein sequence ID" value="AYE35625"/>
        <property type="gene ID" value="CP523_14950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61011">
        <property type="protein sequence ID" value="QAS61011"/>
        <property type="gene ID" value="EI377_09905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14950"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS61011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="327" mass="37290" checksum="DB1D9EA2F7312026" modified="2018-12-05" version="1">MKINKKYILLIFGLTSMGLILTGCNSKDDSIESLDVSKGSIVKEENGNYYNYKFDPKGYSKIETEKVILSYDLETGNYIYNSQGKNGIVAKDKDISIDYANPKGLKLSKDGSYFSYFKDDTYLELVVKDIKTNKEIEVNSNVTISGTLIDWVDDDKLVYYGIDDKKNNGIFIYNIKEEKEEILYKLDNGYIQFLRATTGGVIFVQQTVNNKRILKIVDLNKNVDELTDKILEVNDILKTEKGIFILGKMKDNNYSIYKVEDNNVKRLVFDFPNIIHLEKGLSSDSEGNILFIGSTENFSKEKVYTCIDGAVSSLTTEESKYHFIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHW9</accession>
    <name>A0A386PHW9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBSX family phage terminase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_15285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03108"/>
    <dbReference type="EnsemblBacteria" id="AYE35683">
        <property type="protein sequence ID" value="AYE35683"/>
        <property type="gene ID" value="CP523_15285"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15285"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006437">
        <property type="entry name" value="Phage_terminase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035413">
        <property type="entry name" value="Terminase_L_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035412">
        <property type="entry name" value="Terminase_L_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04466">
        <property type="entry name" value="Terminase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17288">
        <property type="entry name" value="Terminase_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01547">
        <property type="entry name" value="phage_term_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terminase_3" evidence="1">
        <location>
            <begin position="28"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Terminase_3C" evidence="2">
        <location>
            <begin position="265"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="427" mass="49377" checksum="BC94C517F8E71879" modified="2018-12-05" version="1">MIKVKLKSIIAASFYEAHKDIKRGFHTHYWFKGGRGSTKSSFISIEIVLGIMKDAQEGIMSNALILRRVKDTLSESVRDQIKWAIDTLGVSDYWHVPEAKLTITYKPTGQVIRFKGADNPKKVKSTKVPKGYIKYLWYEEVDEFENKSKIDTINQSILRGGPKFFVFYSFNPPESQRNWCNQEVIETREDKYIHHSDYRTVPKEWLGEQFIIEAAHMKKVNPTKYEHDYLGAVTGTGGEVFRNLTIREITDEEIKIFDRLKNGLDFGYAADPLAYLLMHYDKTRKRLYIFGEVYKVQLSNSKAVEEINKLNKLNKRVIADSAEPRTINEFKKLGLNIIGAKKGPDSVEHGLKFLSEEIEEIIIDPVRCPNAKREFMEYEIEKDKNGNLKGEYPDKNNHTIDAARYGMESEINSRKVRVKSKSKLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI56</accession>
    <name>A0A386PI56_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name evidence="2" type="ORF">CP523_07370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673769.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01083"/>
    <dbReference type="EnsemblBacteria" id="AYE34282">
        <property type="protein sequence ID" value="AYE34282"/>
        <property type="gene ID" value="CP523_07370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00246">
        <property type="entry name" value="tRNA_RlmH_YbeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="159" mass="18360" checksum="C1823570307C2AF6" modified="2018-12-05" version="1">MNITLISVGKLKEKYLKQAIDEYSKRLSRYCKLDIIELPDEKTPDNASEKEELQIKDKEGQLILSKIKDNMFVVAMDLKGKQITSEELSDFIENCGVMGNSNIAFVIGGSLGLSQDVIKRANYKLCFSKMTFPHQLFRVMLLEQVYRAFRIMKNEPYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI59</accession>
    <name>A0A386PI59_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 22" type="primary">secA</name>
        <name evidence="21" type="ORF">CP523_10305</name>
        <name evidence="22" type="ORF">EI377_05085</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="22 24" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 24">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01434"/>
    <dbReference type="EnsemblBacteria" id="AYE34761">
        <property type="protein sequence ID" value="AYE34761"/>
        <property type="gene ID" value="CP523_10305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60161">
        <property type="protein sequence ID" value="QAS60161"/>
        <property type="gene ID" value="EI377_05085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="20">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="87"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="418"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="786"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AYE34761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QAS60161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="839" mass="94906" checksum="ABECF8497E673FC0" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI70</accession>
    <name>A0A386PI70_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ORF">CP523_09060</name>
        <name evidence="12" type="ORF">EI377_03805</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678370.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00251"/>
    <dbReference type="EnsemblBacteria" id="AYE34558">
        <property type="protein sequence ID" value="AYE34558"/>
        <property type="gene ID" value="CP523_09060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59958">
        <property type="protein sequence ID" value="QAS59958"/>
        <property type="gene ID" value="EI377_03805"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09060"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE34558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QAS59958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="17508" checksum="C280B46848B51933" modified="2018-12-05" version="1">MRVDPSTLDLKEKVVYINRVTKVVKGGRNFRFSALVVVGDENGHVGVGMGKSIEIPEAIKKGIEDAKKHLVSVAIVENTVPHEIYGKFGTGKVLIMPAKEGTGVIAGGPARSVLELAGLKDVRAKSLGSNNPKNMVNATINGLANLRTAEDIAKLRGKTVEEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PI89</accession>
    <name>A0A386PI89_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_10905</name>
        <name evidence="3" type="ORF">EI377_05700</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02515"/>
    <dbReference type="EnsemblBacteria" id="AYE34874">
        <property type="protein sequence ID" value="AYE34874"/>
        <property type="gene ID" value="CP523_10905"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60269">
        <property type="protein sequence ID" value="QAS60269"/>
        <property type="gene ID" value="EI377_05700"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10905"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFP-like" evidence="1">
        <location>
            <begin position="301"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="357" mass="40114" checksum="904FA09434D214E3" modified="2018-12-05" version="1">MFRRKVNMPEIKIGNVTVSNEGKTFIIAEIGANHNSDIELAKKTIKAAAECGVDAVKFQTYTARELVADKDRVLTYLSNGIEKKETISELFDRLSLRREYHRELFDYANSLGLQAFSTPFSLDGLEFLASLDVPCFKVAASDVNYVDLLEKLPEYNKPVMLSLGKCTLGEADEAINILLNKGCKNLVIMHCVSQYPSPMNEMNLNTIKTLKSLYPECVIGFSDHSMGITAALGAVAFGARVVEKHFTLDKKLDGPDHWFSMDPSDMKSLVTEIRNLESAMGNPRKMILECEKNERHKSVRSLVLKRDLKEGEVIKNEDLLMLRPGWGISPFDKDKVVGMKINKDCKANTVLVWDLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIC9</accession>
    <name>A0A386PIC9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_13790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02064"/>
    <dbReference type="EnsemblBacteria" id="AYE35875">
        <property type="protein sequence ID" value="AYE35875"/>
        <property type="gene ID" value="CP523_13790"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13790"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="66" mass="7502" checksum="25EF8830454CF822" modified="2018-12-05" version="1">MSIFGCNKKDKADTTTKVKLNEVVRSVFYAPMYVAINEGFFEDERLEIDLTTGQGADTTHSYTQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIF5</accession>
    <name>A0A386PIF5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Energy coupling factor transporter S component ThiW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiW</name>
        <name evidence="2" type="ORF">CP523_10840</name>
        <name evidence="3" type="ORF">EI377_05635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677617.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02502"/>
    <dbReference type="EnsemblBacteria" id="AYE34861">
        <property type="protein sequence ID" value="AYE34861"/>
        <property type="gene ID" value="CP523_10840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60256">
        <property type="protein sequence ID" value="QAS60256"/>
        <property type="gene ID" value="EI377_05635"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10840"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012652">
        <property type="entry name" value="ThiW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09512">
        <property type="entry name" value="ThiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024534">
        <property type="entry name" value="ThiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02359">
        <property type="entry name" value="thiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="165" mass="17390" checksum="D8A2C627163D0BB6" modified="2018-12-05" version="1">MNKEKISTKKLALSGILVAISTILGTFSIPFLGAKISPVQHFINVLSAVTIGQVYGVGTAFVTSLLRNILGTGSLLAFPGSMIGAFLDGFIYSKFNKVEGALIGEIIGTGILGAIVAFPIASIILGKDVALFFYVVPFSLSSLFGGIIAYILIKIHSVRILLKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIL1</accession>
    <name>A0A386PIL1_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Class II fructose-1,6-bisphosphate aldolase</fullName>
            <ecNumber evidence="5">4.1.2.13</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Fructose-1,6-bisphosphate aldolase, class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fba</name>
        <name evidence="4" type="ORF">CP523_11530</name>
        <name evidence="5" type="ORF">EI377_06345</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673327.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02864"/>
    <dbReference type="EnsemblBacteria" id="AYE34994">
        <property type="protein sequence ID" value="AYE34994"/>
        <property type="gene ID" value="CP523_11530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60387">
        <property type="protein sequence ID" value="QAS60387"/>
        <property type="gene ID" value="EI377_06345"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11530"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QAS60387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="287" mass="30373" checksum="FD4CD6C62A3AE58E" modified="2018-12-05" version="1">MLVSAKEMLNKAREGKYAVGQFNINNLEWTKAILLTAQENNSPVILGVSEGAGKYMCGYKTIVGMVNGMMEELKITVPVALHLDHGSYEGAKEAMAAGFSSIMFDGSHYAIDENIEKTTEMVKLTSEKGISLEAEVGSIGGEEDGVVGAGEIADAAECKAIADLGVTMLAAGIGNIHGQYPANWQGLSFDALAKINEATGTMPLVLHGGTGIPDDMIKKAISLGVSKINVNTECQLVFAEATRKYIEAGKDVQGKGFDPRKLLAPGTEAIKALVKEKMELFGSINQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIN3</accession>
    <name>A0A386PIN3_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-deoxy-glucuronate isomerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">5-deoxyglucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11685</name>
        <name evidence="3" type="ORF">EI377_06505</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02896"/>
    <dbReference type="EnsemblBacteria" id="AYE35024">
        <property type="protein sequence ID" value="AYE35024"/>
        <property type="gene ID" value="CP523_11685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60418">
        <property type="protein sequence ID" value="QAS60418"/>
        <property type="gene ID" value="EI377_06505"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11685"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="255" mass="29602" checksum="19D0072BB21CBCD2" modified="2018-12-05" version="1">MVENIGFGENGVKIVTEINGKHSNMLMDICVVKINKGDELEILDPKKEVAVLLMEGKIKYIWKNNEVEVSRKNVFEEEGYCLHVCKNEKIRIEAIDNAEILIQKAENHREFEDKLYTPDDVIVQISSLDKWDSTAARKIKTFFDYNNAPYSNMVNGEIVSYPGRWSSYIPHEHPQPEVYYYKFDKKQGFGACFIGDNAYKVKDGGYAVIEGGYTHPQATAPGYRMYYCWMIRHLEGNPWTERIDDPDHIWLLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PIY5</accession>
    <name>A0A386PIY5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12175</name>
        <name evidence="7" type="ORF">EI377_06995</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673559.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02990"/>
    <dbReference type="EnsemblBacteria" id="AYE35111">
        <property type="protein sequence ID" value="AYE35111"/>
        <property type="gene ID" value="CP523_12175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60502">
        <property type="protein sequence ID" value="QAS60502"/>
        <property type="gene ID" value="EI377_06995"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12175"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="173" mass="20617" checksum="8EC0987B3041DC5E" modified="2018-12-05" version="1">MNFFLWIAFNFVLYSFIGWIIEEVYAYFIKGNFKKEGFLKGPFKPMYGFAMTILVVFNRISHPNILIMTILSFIVPTTIEYISGDLLKKVFNKVYWDYSNLTHNFNGLISLRFSFYWTFLCLIGVYYFQPLVDMVYYHFFVIWAIIVPISIFFMMLDLAIIVKENSKININKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ05</accession>
    <name>A0A386PJ05_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="7" type="ORF">CP523_09150</name>
        <name evidence="8" type="ORF">EI377_03895</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678402.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00268"/>
    <dbReference type="EnsemblBacteria" id="AYE34576">
        <property type="protein sequence ID" value="AYE34576"/>
        <property type="gene ID" value="CP523_09150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59976">
        <property type="protein sequence ID" value="QAS59976"/>
        <property type="gene ID" value="EI377_03895"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE34576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS59976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="144" mass="16384" checksum="6E37D928474B1040" modified="2018-12-05" version="1">MKSYIAKEQEVERKWYVVDAAGKPLGRVASQVASILRGKNKPTFTPNVDCGDYVIIINAEQVVLTGKKLDQKLMRKHSLYPGGLKETPYREVLAKKPEFAFEESVRRMLPTGVLGRKMLKKLKVYRGAEHGHEAQQPEVLELKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ25</accession>
    <name>A0A386PJ25_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_09520</name>
        <name evidence="10" type="ORF">EI377_04265</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02610"/>
    <dbReference type="EnsemblBacteria" id="AYE34642">
        <property type="protein sequence ID" value="AYE34642"/>
        <property type="gene ID" value="CP523_09520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60041">
        <property type="protein sequence ID" value="QAS60041"/>
        <property type="gene ID" value="EI377_04265"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="19"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="458" mass="52173" checksum="872EF4DAE638C351" modified="2018-12-05" version="1">MRDILEIFNYQKKFFYEGKTKDVEFRIENLEKLKRIIKDNEDKIINALKKDLSKSAFETYATEIGLVYDEINLHIKNVKKWAKKETRRTSIVHFPARSYIYKEPYGVCLIIGPFNYPFQLVFAPLVGAISSGNCAIVKPSENTIDTAKLIEKLINENFDENYIKVVNPLGGKEVVTYLLDLKFDYIFFTGSVQVGKIVMEKAAKNLIPVTLELGGKSPCIVDKDAKIDISAKRLVWGKFLNAGQTCVAPDYLYVHKNIKDKFLLAVAKEIKAQFGDDIKNSKDLPRIVNECTTRRLIDYMKDGDIYFGGNYNIESNYIEPTILTNLKENSKVLNEEIFGPILPVIEFDDIKQVINYVNLREKPLALYYFSENKKSIEYVLKNTTSGGVTINDTIIHVASTYLPFGGVGSSGLGEYHGKASFDTFSHKKSVIKRGTFFELPIRFAPYGEKIKILKLLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ29</accession>
    <name>A0A386PJ29_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CP523_12820</name>
        <name evidence="7" type="ORF">EI377_07695</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678199.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02801"/>
    <dbReference type="EnsemblBacteria" id="AYE35234">
        <property type="protein sequence ID" value="AYE35234"/>
        <property type="gene ID" value="CP523_12820"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60629">
        <property type="protein sequence ID" value="QAS60629"/>
        <property type="gene ID" value="EI377_07695"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12820"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="276" mass="32168" checksum="84B3559DC6F23AFE" modified="2018-12-05" version="1">MNENMLGYIKEDSIIHNLTGATKLICFILWTLTSMLTYDTRILFIMFIFSIVVFKLSKIKFKDVSFIFYFILFFLILNNIAIFIFSPYEGVNIYGTEHKLLHLIGPYNITTEQLFYQLNVTIKYFSVIPMALLFISTTEPSEFASSLNRIGISYKIAYSVSIALRYIPDIQRDYQDISFAQQARGIDMSKKEKFIKRIKNIAAILMPLIFSSLDRIEKITSAMELRGFGNKKSRTWYNANRFNKNDYMAIIMVIVLFIVSLMITVNNGNRFYNPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ37</accession>
    <name>A0A386PJ37_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GIY-YIG nuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_09355</name>
        <name evidence="3" type="ORF">EI377_04100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02728"/>
    <dbReference type="EnsemblBacteria" id="AYE34616">
        <property type="protein sequence ID" value="AYE34616"/>
        <property type="gene ID" value="CP523_09355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60016">
        <property type="protein sequence ID" value="QAS60016"/>
        <property type="gene ID" value="EI377_04100"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_09355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="81" mass="9721" checksum="D6783EF90A37A39E" modified="2018-12-05" version="1">MNYVYILKCADNTLYTGWTNNLEKRLKTHSLGKGAKYTRCRLPIELVYYETFDDKILAMKREYEIKQLKREEKLNIIKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJG3</accession>
    <name>A0A386PJG3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_01635</name>
        <name evidence="9" type="ORF">CP523_13340</name>
        <name evidence="10" type="ORF">CP523_13925</name>
        <name evidence="11" type="ORF">CP523_15460</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33252">
        <property type="protein sequence ID" value="AYE33252"/>
        <property type="gene ID" value="CP523_01635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35331">
        <property type="protein sequence ID" value="AYE35331"/>
        <property type="gene ID" value="CP523_13340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35436">
        <property type="protein sequence ID" value="AYE35436"/>
        <property type="gene ID" value="CP523_13925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35717">
        <property type="protein sequence ID" value="AYE35717"/>
        <property type="gene ID" value="CP523_15460"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_01635"/>
    <dbReference type="KEGG" id="csep:CP523_13340"/>
    <dbReference type="KEGG" id="csep:CP523_13925"/>
    <dbReference type="KEGG" id="csep:CP523_15460"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AYE35717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="406" mass="46736" checksum="50C2F1114E51E5D4" modified="2018-12-05" version="1">MSFSKEELIKILAKDPNIKTAEDIQNVLKDLFGGMLQQMLEAELDNHLGYEKHDYQNKNTTNSRNGKSRKTMKSNLGYFDLDVPRDREGSFEPEIVKKHQTDVSHLESSIIGMYAKGMTTRDIASQVNEIYGMDISPTLVSNITDKVIPMIREWQSRPLETVYPIVFMDAIHFKVRKDNTVVSKAAYAAIGVNIEGKKDVLGIWIGASESSKYWLLVLNELKNRGVKDILIASVDGLVGFNEAIRAVYPNTEIQRCIIHQIRNSSKYLSYKDLKAFNADLKLVYTASTEEVALAELDRLEEKWGEKYLIAVRSWRNNWNELSTFFKYPPEIRKIIYTTNAMESYNRQLRKVTKTKSIFPNDESLMKILYLATVDITKKWTQSIRGWAQILAQLSIFFEGRLDDQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJL6</accession>
    <name>A0A386PJL6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_12260</name>
        <name evidence="11" type="ORF">EI377_07085</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03007"/>
    <dbReference type="EnsemblBacteria" id="AYE35128">
        <property type="protein sequence ID" value="AYE35128"/>
        <property type="gene ID" value="CP523_12260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60520">
        <property type="protein sequence ID" value="QAS60520"/>
        <property type="gene ID" value="EI377_07085"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12260"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="9">
        <location>
            <begin position="196"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="438" mass="49045" checksum="7042BE71DB72736E" modified="2018-12-05" version="1">MKGLKVVTIGGGSSYTPELIEGFIKRYNELPLRELWLVDIEEGKEKLQIVGELAKRMVKKSGLPIDIRLTLDRREALKDADFVTTQIRVGLLEARIKDERIPLSKGYIGQETNGAGGLFKGLRTIPVLIDITKDMKELCPNAWLINFTNPVGMVTEALLKYGAIDKVIGLCNVPIGLEKSTAKILGVDSSRVRIDFAGLNHMVFGLNIYLDGKVVTDKVIKKIIEADASSEVKNIDEVKWKSEFLKGLGVLPCSYAKYYFMKDYMLNSELEKFKENGTRAEVVKKLENELFELYKDKNLNVKPQQLEERGGAFYSDAACRLIDSIYNDRRDIQPVDTMNRGSIADLEYNSAVEVSCIITKDGPKPITVGHLPIQIRGLIQQIKSFEMLGAKAAAEGDYNAGVVAMTINPLVQSDKMAKILFDELLQAHKKYLPQFNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJM8</accession>
    <name>A0A386PJM8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Probable 2-phosphosulfolactate phosphatase</fullName>
            <ecNumber evidence="3 8">3.1.3.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">comB</name>
        <name evidence="9" type="ORF">CP523_08150</name>
        <name evidence="10" type="ORF">EI377_02905</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">VAT12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15597"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58738"/>
            <dbReference type="EC" id="3.1.3.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ComB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.71" evidence="3 8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34399">
        <property type="protein sequence ID" value="AYE34399"/>
        <property type="gene ID" value="CP523_08150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59804">
        <property type="protein sequence ID" value="QAS59804"/>
        <property type="gene ID" value="EI377_02905"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08150"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050532">
        <property type="term" value="F:2-phosphosulfolactate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00490">
        <property type="entry name" value="ComB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005238">
        <property type="entry name" value="ComB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036702">
        <property type="entry name" value="ComB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37311">
        <property type="entry name" value="PTHR37311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04029">
        <property type="entry name" value="2-ph_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142823">
        <property type="entry name" value="SSF142823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QAS59804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="240" mass="26698" checksum="76558A9F96648336" modified="2018-12-05" version="1">MKVDVIISADYINEDYLEGKTVVVIDMLRATSVITTALANGAKKVIPLLTVEEAFDMKEKLNGLGEEVLLGGERRALKIEGFDFTNSPLEYTESKVKDKNIIITTTNGTRAIALSLNAESILVGAMINAKAIVNKVKEINKDVVFINAGTNGEFSMDDFICSGYMINILSEEKEQDLTDIARTAMITYKSNPNIISYIKDARHYNILKNLNLQNDLGYCCKKDIIEVVPKYDKDKKCIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJN3</accession>
    <name>A0A386PJN3_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="6" type="ORF">CP523_10660</name>
        <name evidence="7" type="ORF">EI377_05445</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674147.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01370"/>
    <dbReference type="EnsemblBacteria" id="AYE34826">
        <property type="protein sequence ID" value="AYE34826"/>
        <property type="gene ID" value="CP523_10660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60221">
        <property type="protein sequence ID" value="QAS60221"/>
        <property type="gene ID" value="EI377_05445"/>
    </dbReference>
    <dbReference type="GeneID" id="66302534"/>
    <dbReference type="KEGG" id="csep:CP523_10660"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS60221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="99" mass="10844" checksum="DF65644BA8A111CB" modified="2018-12-05" version="1">MLMMNLQLFAHKKGVGSSKNGRDSESKRLGVKAADGEFVLAGNILVRQRGTKIHPGTNVGKGGDDTLFAKEDGIVRFERMGRDKKKVSIYPVNVEEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJW0</accession>
    <name>A0A386PJW0_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase 3</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA topoisomerase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">topB</name>
        <name evidence="8" type="ORF">CP523_14370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676797.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02464"/>
    <dbReference type="EnsemblBacteria" id="AYE35521">
        <property type="protein sequence ID" value="AYE35521"/>
        <property type="gene ID" value="CP523_14370"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00953">
        <property type="entry name" value="Topoisom_3_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TopoIII"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
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        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
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        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="6">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
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    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="6">
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            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
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        <location>
            <position position="105"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <position position="61"/>
        </location>
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    <feature type="site" description="Interaction with DNA" evidence="6">
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        </location>
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    <feature type="site" description="Interaction with DNA" evidence="6">
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            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="311"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="727" mass="83052" checksum="FDE999EC779AD279" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJX6</accession>
    <name>A0A386PJX6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11165</name>
        <name evidence="3" type="ORF">EI377_05955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677056.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE34926">
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        <property type="gene ID" value="CP523_11165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60320">
        <property type="protein sequence ID" value="QAS60320"/>
        <property type="gene ID" value="EI377_05955"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="226" mass="25994" checksum="D3BDE99619852516" modified="2018-12-05" version="1">MNGNFIKDERLTKQVNQVNTQSFIIMEILCIISIIIKGIIFKELLLCFIELLILIGGNLYIGIEIVINKINPVVFIKEKNDEMIIDYKRKIISRCFIGGFILTLIAPAPYLFLYNNLYAAMSYMIIMFISAGYATFKYVKDGLFIPLRRKDKKDWKKSFKRNVVIGSLFFGFSTNLNKIFLNGVFHPKGLIGVLISAGLWGCMFYTSMLFMIKFSTKLADKKIDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK22</accession>
    <name>A0A386PK22_CLOSE</name>
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        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CP523_14770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676125.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01330"/>
    <dbReference type="EnsemblBacteria" id="AYE35591">
        <property type="protein sequence ID" value="AYE35591"/>
        <property type="gene ID" value="CP523_14770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14770"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AYE35591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="379" mass="41535" checksum="E17A2DCBEEE7C82E" modified="2018-12-05" version="1">MDFNLSKEQELVRQLTRDFTEKEIKPVVINYDEKGEFPINIYKKMGEIGLIGIPYPREYSGAGGDYLSYVIAIEEVSKICASLGIAQSVTTSLCSGAIYNNGTEKQKKKYLPDLLKGRKVGCFGLTESNAGSDASGLQTVAIKNGDNYILNGTKTFITNAPLADIFVIVAITDKAKGPKGISTFIVEKDFKGISIGNIENKCGIRSAQVSEILLDNCIVPAENMLGREGQGLKIALASLDGGRIGVAAQGLGIAEGAFEIAKNYMKERKQFGKPLFKNQYLAFKMAELEIEIEQSKYILYKAAMDKQEGKPYGLSAAKAKVCCTNTAMKVTTEAVQMLGGYGYMKDYHVERMFRDAKITQIYEGTNEIQKLIISGTLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK46</accession>
    <name>A0A386PK46_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CP523_14930</name>
        <name evidence="6" type="ORF">EI377_09885</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676067.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01298"/>
    <dbReference type="EnsemblBacteria" id="AYE35621">
        <property type="protein sequence ID" value="AYE35621"/>
        <property type="gene ID" value="CP523_14930"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61007">
        <property type="protein sequence ID" value="QAS61007"/>
        <property type="gene ID" value="EI377_09885"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14930"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AYE35621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QAS61007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="303" mass="34367" checksum="04F85E052E708F08" modified="2018-12-05" version="1">MNEFIFKIEEKYKNSRIDKYLSEVIDGKSRSFIQGIIDDKGVSVNGKIVKSNYKLKIDDEVIVKIPEATILEVDPEDIPLDIIYEDEDIIVVNKPQGMVVHPAPGNYTGTLVNALLYHCKDLSGINGVIRPGIVHRIDKDTSGILVVAKNDEAHNNLAAQFKEHSIKREYYALVNGKFVNTRGTIDKPLGRNKKDRLKIAIVEDGKRAVTHYEVLEQYNTNISLVKCTLETGRTHQIRVHMASIGHPLIGDALYGLKKQKFNLIGQALHAKTLGFIHPRFSTYIEFNSELPEYYNKLLKELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PK70</accession>
    <name>A0A386PK70_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">CP523_15090</name>
        <name evidence="7" type="ORF">EI377_10045</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676010.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01266"/>
    <dbReference type="EnsemblBacteria" id="AYE35651">
        <property type="protein sequence ID" value="AYE35651"/>
        <property type="gene ID" value="CP523_15090"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS61038">
        <property type="protein sequence ID" value="QAS61038"/>
        <property type="gene ID" value="EI377_10045"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15090"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS61038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="283" mass="31558" checksum="8424B61960E70E0A" modified="2018-12-05" version="1">MKNIAIAINPSKDKNGEIIEKVKKEVLKEFKNVNIVVLNSYEIANYNFNNHIDFIIVLGGDGTILGVARQINGKADIPLLGINIGNLGFISSIEISDISKAIRNLKEGNYKIENRIMLECEFSLQEANDKCKALNDVVVARGTLSRMVKFHVFIDGKRYYTFKGDGLIVGTPTGSTAYSFSAGGPFVYPNLDVITLTPICSHTKGMQTIVLNSDSEIEIKAENGEEEIYITFDGQKAVRSNHEALIKVKKSKEYAKIILFNDYDYFKVLRTKIINNSKECEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKA9</accession>
    <name>A0A386PKA9_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ClC family H(+)/Cl(-) exchange transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_15495</name>
        <name evidence="8" type="ORF">EI377_10200</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS61063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="CP523_15495"/>
    </dbReference>
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        <property type="gene ID" value="EI377_10200"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cation transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
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            <end position="81"/>
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            <end position="129"/>
        </location>
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            <end position="209"/>
        </location>
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            <end position="379"/>
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        <location>
            <begin position="436"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS61063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="520" mass="56639" checksum="0464B421C9011AA8" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKF2</accession>
    <name>A0A386PKF2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Multidrug ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_12305</name>
        <name evidence="3" type="ORF">EI377_07130</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_03017"/>
    <dbReference type="EnsemblBacteria" id="AYE35136">
        <property type="protein sequence ID" value="AYE35136"/>
        <property type="gene ID" value="CP523_12305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60528">
        <property type="protein sequence ID" value="QAS60528"/>
        <property type="gene ID" value="EI377_07130"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12305"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
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            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE35136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="364" mass="40683" checksum="EF4C8D71A1DB1EDE" modified="2018-12-05" version="1">MRALYYIKTTLKGMISNGLVTISYFVLFPVLLAFFMAFFQGIVHENPLKLKQLKVQVIDEDKTEMSKNLTNLLENDEMKKVVSIVDEKPEVELKIEKGYEDKILSLSKGNIIINKKVEESNISTNTLKVILDKYHQNLYVSIGGGNIENLEKISDETIVENTTIDIVKTATPYEKLSASMIGFVITMLIFSVIQSGYADISINLEKRVNSTPITKLQYLFYDTMALLIFVFIIISGYIMFFRLVGLSFKGNLLDLLLLILTGTVLVVSISTTISTIFGAKYGKIMGGVIFTLPLISGEIFMGEGNKIALLTPTHYLNNAFSLYNLNGNLEGCGKWILMIFIISSIVYSMSIIKAGFNRGKKICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKF4</accession>
    <name>A0A386PKF4_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">prfA</name>
        <name evidence="8" type="ORF">CP523_10115</name>
        <name evidence="9" type="ORF">EI377_04915</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QAS60130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676600.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00352"/>
    <dbReference type="EnsemblBacteria" id="AYE34729">
        <property type="protein sequence ID" value="AYE34729"/>
        <property type="gene ID" value="CP523_10115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60130">
        <property type="protein sequence ID" value="QAS60130"/>
        <property type="gene ID" value="EI377_04915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_10115"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="361" mass="40723" checksum="88503866EB412A44" modified="2018-12-05" version="1">MLLDKLAFIENKYEELSVKISDPSIMANQAEWRKLCKEHADLEIIVTAYKEYKTVTEDLQANKEMLSEESDKEMREMLSEEISMLTAREEELENHIQILLLPKDPNDDKNVFVEIRGGAGGDEAALFAANLFRMYTRYAENQRWSVELMSANETDIGGFKEVVFMIKGHGAYSKLKYESGVHRVQRVPDTESSGRIHTSTATVAVLPEVDDVEIEINEKDLRIDVYRSSGNGGQCVNTTDSAVRITHLPTGLVVACQDEKSQLKNKEKAMKVLRSRLYEAAEAERAAGIAEDRKSQVGSGDRSERIRTYNYPQGRVTDHRIGLTLYKLESYLNGDIDEVINALITADQAEKMKQMGNTDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKL6</accession>
    <name>A0A386PKL6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MerR family DNA-binding transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_07215</name>
        <name evidence="4" type="ORF">EI377_01970</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01060"/>
    <dbReference type="EnsemblBacteria" id="AYE35841">
        <property type="protein sequence ID" value="AYE35841"/>
        <property type="gene ID" value="CP523_07215"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59660">
        <property type="protein sequence ID" value="QAS59660"/>
        <property type="gene ID" value="EI377_01970"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_07215"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS59660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="271" mass="32214" checksum="FB506C02F8CFEAA0" modified="2018-12-05" version="1">MKNLFSIGEISKIKEITIKALRYYHKVGILIPRYIDEKSGYRYYSIDQFIYIDIIKGCRALGTSIAELQEIFKECNTDKLIEFLQLKRIEAKKNISKMEEIIKNIDRLNMEVEQSKNILNNDEMEISFFKKRYIIVVPCKEVGSLKELIYYSDLEKVIHERDIDVYMERGIIYNIESNGNVKPGYVFNTIKDDIKSKDDNYIKVLPEGRYLTLAYSKANEEIQREKLFNYIEKNKLKIRSFIEIDLFNDFFNIESYSCQIQVFIEDDELIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKQ8</accession>
    <name>A0A386PKQ8_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CP523_15160</name>
        <name evidence="17" type="ORF">EI377_10115</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066679011.1">
        <property type="nucleotide sequence ID" value="NZ_CABMIZ010000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00096"/>
    <dbReference type="EnsemblBacteria" id="AYE35891">
        <property type="protein sequence ID" value="AYE35891"/>
        <property type="gene ID" value="CP523_15160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62201">
        <property type="protein sequence ID" value="QAS62201"/>
        <property type="gene ID" value="EI377_10115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15160"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBP5_C" evidence="15">
        <location>
            <begin position="269"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AYE35891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QAS62201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="377" mass="42049" checksum="CB6CFBD26EFDAC12" modified="2018-12-05" version="1">MDDGVEETYKEWDTEVFNDEGINVEAKSALLIEPTTGKIIYEKNIDEKFAPASVTKIMTMLLTMEAVDSGKITLQDKVTCSENAKKMGGSTMLLETGEVRTVEELLKGVAIASGNDAAVALAEYLGGTEEAFVEMMNKKAKELEMTNTTFKNCNGLPAQGHESTARDISIMSMELLKHPQILKYSGTYMETISEGRKSPIELVNHNKLVRFFEGCDGLKTGYTEEAKYCISATATKSGVRMLSVIMGAPTYKIRNRDAGMLLNYGFSKYEGKKLVLKDEDVETVYLSKQTDKFFMAKAKDDLIVVLPKGSNGELEKRIVMDEIKKEYKEGEAVGKCEVYLGEEKVGEVELYSDRDIKVGGFFENFKFNMKNMFKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKY5</accession>
    <name>A0A386PKY5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ruvA</name>
        <name evidence="10" type="ORF">CP523_14165</name>
        <name evidence="11" type="ORF">EI377_09070</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066678529.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00289"/>
    <dbReference type="EnsemblBacteria" id="AYE35482">
        <property type="protein sequence ID" value="AYE35482"/>
        <property type="gene ID" value="CP523_14165"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60868">
        <property type="protein sequence ID" value="QAS60868"/>
        <property type="gene ID" value="EI377_09070"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14165"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QAS60868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="201" mass="22432" checksum="F0B6A75C3181B535" modified="2018-12-05" version="1">MYEYIKGKYMGINKDYIVVENNGLGYKVFTSGATMSSMPKVGEDIMLYLEQIVREDFLGLYGFDSREELEMFKMLLSINGVGAKAALSLLSISRINNLKYAIMMGDDKHLCRAPGIGKKTAGRIILELKDKLKPDELIDDIENVESIENIEKYNVNVISEALGALLALGYSEKEAESALRKVNKDDTVENIIKSCLKVLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL25</accession>
    <name>A0A386PL25_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bifunctional folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_14430</name>
        <name evidence="9" type="ORF">EI377_09405</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676818.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02479"/>
    <dbReference type="EnsemblBacteria" id="AYE35532">
        <property type="protein sequence ID" value="AYE35532"/>
        <property type="gene ID" value="CP523_14430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60919">
        <property type="protein sequence ID" value="QAS60919"/>
        <property type="gene ID" value="EI377_09405"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_14430"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="6">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS60919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="437" mass="49909" checksum="83E0371A4FF995F0" modified="2018-12-05" version="1">MKYEDAMKYITEVGNFGSNYGLERTYRLLELLDNPQEKINLIHIAGTNGKGSTTAIISRILQGHGYKVGMYTSPFLEEFEERIQINGMNIPKEKLADLMEKVKKAVDKVIEEGYNHPTEFEIITCLMYLYFYIENVDFGVIEVGLGGRLDSTNVITPILSVITSISLDHVNILGNSLKEIANEKSGIIKNKVPVVIFPQKKDAFDIIKKKCEEENASLYVIDENDWEFIDVVREDGIYQKIRVKYNKEELEVNFPLLGEHQILNLSVALKAIEILEKNGFLKISKEIIKKSLESVVWKGRLEVMNVNPLVVIDGAHNIQGITTLKSNIKKYFEYRNLYLILGILADKDVERMVKEITPMAKKVYSVTPNSLRAELSEDLKKEILKYNSNCYAYEDYEEALNSSLKDATEEDLIIASGSLYMIADMRKIITNKFIKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PL32</accession>
    <name>A0A386PL32_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese catalase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Manganese catalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13875</name>
        <name evidence="4" type="ORF">EI377_08770</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">VAT12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35426">
        <property type="protein sequence ID" value="AYE35426"/>
        <property type="gene ID" value="CP523_13875"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60814">
        <property type="protein sequence ID" value="QAS60814"/>
        <property type="gene ID" value="EI377_08770"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13875"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QAS60814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="223" mass="25081" checksum="4E2E5C1BC050A71F" modified="2018-12-05" version="1">MFKHEKQLLRDVMVEKPNPQYAVLMQEQLGGGNGELKAAMQYMAQSFRIKDKEIKDLFLDIAAEELSHMEMVAQTINLLNGHDVDNCKVTSGEIQTHVQCGLSPVLINSSGAPWTADYVTVTGDLVADLLSNIASEQRAKVVYEYLYRQIDDKYVKETIDFLLNREEAHNALFREALNKVQNTGSNKDFGVTEDSKLYFDLSSPGVDHKNPNPTPPSFENPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLE5</accession>
    <name>A0A386PLE5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_15330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35692">
        <property type="protein sequence ID" value="AYE35692"/>
        <property type="gene ID" value="CP523_15330"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_15330"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010064">
        <property type="entry name" value="HK97-gp10_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04883">
        <property type="entry name" value="HK97-gp10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01725">
        <property type="entry name" value="phge_HK97_gp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE35692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="157" mass="17910" checksum="24685A53A122DECF" modified="2018-12-05" version="1">MSRSVVGLDNLLKKLNKLGGNVEETLYKSMQRQGELVKGDAKDLCPVDTGDLRQSIKSETKNYKNKITTRVYTNSDHAAYVEFGTGKVGERTNKNNKVNVSYKQDKWLANIPDVGVRWVEGQPAQPYLYPALKNNEKIVVENIKEDVKKEIERILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PLM5</accession>
    <name>A0A386PLM5_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CP523_03635</name>
        <name evidence="8" type="ORF">EI377_14165</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">VAT12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02218"/>
    <dbReference type="EnsemblBacteria" id="AYE35812">
        <property type="protein sequence ID" value="AYE35812"/>
        <property type="gene ID" value="CP523_03635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62230">
        <property type="protein sequence ID" value="QAS62230"/>
        <property type="gene ID" value="EI377_14165"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_03635"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AYE35812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QAS62230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="238" mass="25842" checksum="529D740B48DDE454" modified="2018-12-05" version="1">MNKASNDRVLGIIGAMEEEVEILKAKMEIKETIDVAGMKFYKGKLDGKNIVLVRSGVGKVNMATCTEILVDKFNVTALVNSGVAGTMNPELKQGDIVISKDAVQHDFDTTVFGDPLGQISRLDITFFEADKNMIEVSKEAANHVSGITIKEGRVASGDQFVAGGEVAKRIKENFGEVEAVEMEGASMAQVAYLNKIPFVILRSISDKANGEADLSYEEFLPIAAKNASNLLEEFVKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PM02</accession>
    <name>A0A386PM02_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS5/IS1182 family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CP523_13855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35876">
        <property type="protein sequence ID" value="AYE35876"/>
        <property type="gene ID" value="CP523_13855"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_13855"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="2">
        <location>
            <begin position="390"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AYE35876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="542" mass="63182" checksum="6491B323AB8664EF" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PCR5</accession>
    <name>A0A386PCR5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CP523_04380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 7534</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE33763">
        <property type="protein sequence ID" value="AYE33763"/>
        <property type="gene ID" value="CP523_04380"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_04380"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AYE33763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="183" mass="21999" checksum="07684507CB7CDC78" modified="2018-12-05" version="1">MEVYTLDIMKEIIRWQSGNYDAFNKIYTRYYERIYWLCFNILKEEDDAMDATQETFIEALKRINKLKNVKAFYSWIRKIAVCICNKIIIKNKKNLIINDEDLKLYKDSEDQRPEVVFLKNENRDLMLSSINRLKAKKRDVIFLYYYKDLDIQTISEVLNCPVGTVKSRLNSARNDLKNYYKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PFY6</accession>
    <name>A0A386PFY6_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_05235</name>
        <name evidence="2" type="ORF">EI377_15795</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE33921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS62072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066676249.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01836"/>
    <dbReference type="EnsemblBacteria" id="AYE33921">
        <property type="protein sequence ID" value="AYE33921"/>
        <property type="gene ID" value="CP523_05235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS62072">
        <property type="protein sequence ID" value="QAS62072"/>
        <property type="gene ID" value="EI377_15795"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_05235"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE33921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS62072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="345" mass="38594" checksum="9C4B057CC5E4AAEB" modified="2018-12-05" version="1">MKIEKKFLTNLHRCYATSSTVIDNERKILIATEGEGACYMYSGDDFKQSTVWDGPGGTMSMIPVPGKNGDFLAVQNFFPTFQSEKATIVWAKPTENDGFEVKTILDLPYVHRFDILKANGVNYFLGATLCTTKTCKDDWSDPGKIYVGVIPEDLNQPIELKVIKEGLTKNHGYCRAMWNGKEVGMVTSQDGVFVVTPPQNENEDWTVEQIMDKPVSDIAVVDIDGDGVDELVTIEEFHGKNFIINKKIGDKYEEVYKYPKDMDFGHVVWGGKLRGVPTIIGGYRRNEKELFYIQCESTNPLKFKATTIEAGVGPSNVAVLNEKDRDIIISANRELGEAALYIVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PGJ5</accession>
    <name>A0A386PGJ5_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CP523_06520</name>
        <name evidence="2" type="ORF">EI377_01005</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02181"/>
    <dbReference type="EnsemblBacteria" id="AYE34151">
        <property type="protein sequence ID" value="AYE34151"/>
        <property type="gene ID" value="CP523_06520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59519">
        <property type="protein sequence ID" value="QAS59519"/>
        <property type="gene ID" value="EI377_01005"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_06520"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AYE34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QAS59519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="202" mass="23607" checksum="9F2DD7634CBF26A9" modified="2018-12-05" version="1">MKKKILLVLLLCIPFISIILVVIFRLTAEPTNEEIIGKLRDTPYYSVNVEYTVKNTRGEESEDTILYYSKDKGSRIDFGQDRVKIYRDGSITIKDNIANKEYTMEEDMDKLHTIALMSNLLSFPIEEGSIEEGQEEWGETQYITFTSELFFENDHLNKIRIYIDKNERIPLGAVIYDKDGKDRVRIIYRDFKKLKEIDGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PHA2</accession>
    <name>A0A386PHA2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic ribonucleoside-triphosphate reductase</fullName>
            <ecNumber evidence="7">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdD</name>
        <name evidence="6" type="ORF">CP523_08370</name>
        <name evidence="7" type="ORF">EI377_03115</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01615"/>
    <dbReference type="EnsemblBacteria" id="AYE34441">
        <property type="protein sequence ID" value="AYE34441"/>
        <property type="gene ID" value="CP523_08370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59844">
        <property type="protein sequence ID" value="QAS59844"/>
        <property type="gene ID" value="EI377_03115"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08370"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="5">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AYE34441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QAS59844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="705" mass="79658" checksum="44A63F6B080FF88F" modified="2018-12-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ34</accession>
    <name>A0A386PJ34_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CP523_11125</name>
        <name evidence="3" type="ORF">EI377_05915</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">VAT12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066677068.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_00915"/>
    <dbReference type="EnsemblBacteria" id="AYE34918">
        <property type="protein sequence ID" value="AYE34918"/>
        <property type="gene ID" value="CP523_11125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60312">
        <property type="protein sequence ID" value="QAS60312"/>
        <property type="gene ID" value="EI377_05915"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11125"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AYE34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QAS60312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="92" mass="10434" checksum="3E64397B9E8E031E" modified="2018-12-05" version="1">MDNNYKQFEEVAEFLKVLAHPVRLCIVKGLLEKGCCNVSSMQNCMEMPQSTISQHLQKLRSVGIIKGERNGLEIVYKIADSRVEKILEALII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJ78</accession>
    <name>A0A386PJ78_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">pheA</name>
        <name evidence="23" type="ORF">CP523_11395</name>
        <name evidence="24" type="ORF">EI377_06210</name>
    </gene>
    <organism evidence="23 25">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="24 26" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 26">VAT12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS60361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066673270.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_02835"/>
    <dbReference type="EnsemblBacteria" id="AYE34968">
        <property type="protein sequence ID" value="AYE34968"/>
        <property type="gene ID" value="CP523_11395"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS60361">
        <property type="protein sequence ID" value="QAS60361"/>
        <property type="gene ID" value="EI377_06210"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_11395"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011279">
        <property type="entry name" value="Chorismate_mutase_GmP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01805">
        <property type="entry name" value="CM_mono_grmpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 24" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="21">
        <location>
            <begin position="105"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AYE34968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QAS60361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="375" mass="43644" checksum="CF5FC4BA308C72AD" modified="2018-12-05" version="1">MNELEACRKEIDEIDKELVELFERRMNVAVRVAEYKKKNNLPIFNEAREKQVIEKNIENLKNKEYANLTRIFFNNLMELSRSLQDKLILKKSEVIKSKFNVENYKLGFQGVRGSFSEEALIKYFGACNNSRGYEEFKEVFEALKNQEIDYGILPIENSCTGAITRVYDLLAEYGFYIVGEECIKIDQHLMGIKGSNIENIEEVYSHPQGFEQSREFLSHNHDLKLIPYHNTAISAKLISDLKDKSKAAIASKRAAEIYNLEILKEKINDKKNNHTKFIIVGRSLEVSEECNKVTVVFSLEDKVGTLYELLRYFAENNINMIKIESRPNKHESWKYLLYVDFQGNIKDKEVKKSLDLIEKNSGYFKLLGSYKKSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PJS2</accession>
    <name>A0A386PJS2_CLOSE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CP523_08410</name>
        <name evidence="9" type="ORF">EI377_03155</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ehlers B."/>
                <person name="Leendertz F.H."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">DSM 7534</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2018-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete genome sequence of a Clostridium septicum isolate associated with gangrenous dermatitis in turkeys.</title>
            <authorList>
                <person name="Mahsoub H.M."/>
                <person name="Lighty M.E."/>
                <person name="Sriranganathan N."/>
                <person name="Pierson F.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">VAT12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP034358">
        <property type="protein sequence ID" value="QAS59852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_066674795.1">
        <property type="nucleotide sequence ID" value="NZ_FLTT01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1504.GCA_900092375_01623"/>
    <dbReference type="EnsemblBacteria" id="AYE34449">
        <property type="protein sequence ID" value="AYE34449"/>
        <property type="gene ID" value="CP523_08410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="QAS59852">
        <property type="protein sequence ID" value="QAS59852"/>
        <property type="gene ID" value="EI377_03155"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_08410"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000288332">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AYE34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QAS59852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000288332"/>
        </source>
    </evidence>
    <sequence length="330" mass="35496" checksum="73BB6BE25B6FE124" modified="2018-12-05" version="1">MKQSNKHTIIFIICSLLLLIGGLVLAIRLGSVHLTFTDIWDSIFNYSENLQLMLIRDVRIPRALSVLLTGGILGVTGAMIQGITRNPIAEPSILGISQGATLVIATFYATGIAINTKNVMIASFIGALITGIMVLGFISKRANNNSIAKILLAGTAMSTFFISLTTVIGLLSNQSQMIGFWVAGGFRNASWSDFKLVFIVGIIGLIIAVFLSPKINILNLGDDVAIGLGENPEKIRFTTLMIMIPMCAAAVAVGKNIAFVGLIVPQIIRKILGEDYRKNIPCAFLLGAVLLTYADIAARMFFAPYETPIGVFTALIGIPFFISVARKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-12-05" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A386PKG2</accession>
    <name>A0A386PKG2_CLOSE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CP523_12355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Clostridium septicum</name>
        <dbReference type="NCBI Taxonomy" id="1504"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Clostridiaceae</taxon>
            <taxon>Clostridium</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2017-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Thomas P."/>
                <person name="Seyboldt C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 7534</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP023671">
        <property type="protein sequence ID" value="AYE35146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AYE35146">
        <property type="protein sequence ID" value="AYE35146"/>
        <property type="gene ID" value="CP523_12355"/>
    </dbReference>
    <dbReference type="KEGG" id="csep:CP523_12355"/>
    <dbReference type="Proteomes" id="UP000280586">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017330530" description="Beta-N-acetylhexosaminidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1423"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1396"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AYE35146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000280586"/>
        </source>
    </evidence>
    <sequence length="1455" mass="163644" checksum="CC3559BCA4673442" modified="2018-12-05" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>